"Proteins Unique Sequence ID" "Checked" "Protein FDR Confidence: Combined" "Master" "Accession" "Description" "Exp. q-value: Combined" "Contaminant" "Sum PEP Score" "Coverage [%]" "# Peptides" "# PSMs" "# Unique Peptides" "# AAs" "MW [kDa]" "calc. pI" "Score Sequest HT: Sequest HT" "# Peptides (by Search Engine): Sequest HT" "Biological Process" "Cellular Component" "Molecular Function" "Pfam IDs" "Entrez Gene ID" "Ensembl Gene ID" "Gene Symbol" "Gene ID" "WikiPathways" "Reactome Pathways" "# Protein Pathway Groups" "# Razor Peptides" "Abundance Ratio: (127N, 52C) / (126, 52C)" "Abundance Ratio: (127C, 52C) / (126, 52C)" "Abundance Ratio: (128N, 52C) / (126, 52C)" "Abundance Ratio: (128C, 52C) / (126, 52C)" "Abundance Ratio: (129N, 52C) / (126, 52C)" "Abundance Ratio: (129C, 52C) / (126, 52C)" "Abundance Ratio: (130N, 52C) / (126, 52C)" "Abundance Ratio: (130C, 52C) / (126, 52C)" "Abundance Ratio: (131, 52C) / (126, 52C)" "Abundances (Grouped): 126, 52C" "Abundances (Grouped): 127N, 52C" "Abundances (Grouped): 127C, 52C" "Abundances (Grouped): 128N, 52C" "Abundances (Grouped): 128C, 52C" "Abundances (Grouped): 129N, 52C" "Abundances (Grouped): 129C, 52C" "Abundances (Grouped): 130N, 52C" "Abundances (Grouped): 130C, 52C" "Abundances (Grouped): 131, 52C" "Abundances (Grouped) CV [%]: 126, 52C" "Abundances (Grouped) CV [%]: 127N, 52C" "Abundances (Grouped) CV [%]: 127C, 52C" "Abundances (Grouped) CV [%]: 128N, 52C" "Abundances (Grouped) CV [%]: 128C, 52C" "Abundances (Grouped) CV [%]: 129N, 52C" "Abundances (Grouped) CV [%]: 129C, 52C" "Abundances (Grouped) CV [%]: 130N, 52C" "Abundances (Grouped) CV [%]: 130C, 52C" "Abundances (Grouped) CV [%]: 131, 52C" "Abundance: F37: 126, Sample, 52C" "Abundance: F37: 127N, Sample, 52C" "Abundance: F37: 127C, Sample, 52C" "Abundance: F37: 128N, Sample, 52C" "Abundance: F37: 128C, Sample, 52C" "Abundance: F37: 129N, Sample, 52C" "Abundance: F37: 129C, Sample, 52C" "Abundance: F37: 130N, Sample, 52C" "Abundance: F37: 130C, Sample, 52C" "Abundance: F37: 131, Sample, 52C" "Abundances Count: F37: 126, Sample, 52C" "Abundances Count: F37: 127N, Sample, 52C" "Abundances Count: F37: 127C, Sample, 52C" "Abundances Count: F37: 128N, Sample, 52C" "Abundances Count: F37: 128C, Sample, 52C" "Abundances Count: F37: 129N, Sample, 52C" "Abundances Count: F37: 129C, Sample, 52C" "Abundances Count: F37: 130N, Sample, 52C" "Abundances Count: F37: 130C, Sample, 52C" "Abundances Count: F37: 131, Sample, 52C" "Found in Sample: [S331] F37: 126, Sample, 52C" "Found in Sample: [S332] F37: 127N, Sample, 52C" "Found in Sample: [S333] F37: 127C, Sample, 52C" "Found in Sample: [S334] F37: 128N, Sample, 52C" "Found in Sample: [S335] F37: 128C, Sample, 52C" "Found in Sample: [S336] F37: 129N, Sample, 52C" "Found in Sample: [S337] F37: 129C, Sample, 52C" "Found in Sample: [S338] F37: 130N, Sample, 52C" "Found in Sample: [S339] F37: 130C, Sample, 52C" "Found in Sample: [S340] F37: 131, Sample, 52C" "# Protein Groups" "Modifications" "5927523368410573672" "False" "High" "IsMasterProtein" "P78527" "DNA-dependent protein kinase catalytic subunit OS=Homo sapiens OX=9606 GN=PRKDC PE=1 SV=3" "0.000" "False" "382.907" "22" "92" "175" "92" "4128" "468.8" "7.12" "464.91" "92" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf08163, Pf19704, Pf20502" "5591" "ENSG00000253729" "PRKDC" "hsa:5591; P78527; P78528; Q13327; Q13337; Q14175; Q59H99; Q7Z611; Q96SE6; Q9UME3" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Fas ligand pathway and stress induction of heat shock proteins; Pathways affected in adenoid cystic carcinoma; Non-homologous end joining; Osteoblast differentiation and related diseases; DNA repair pathways, full network; DNA damage response" "E3 ubiquitin ligases ubiquitinate target proteins; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); IRF3-mediated induction of type I IFN" "13" "0" "0.979" "0.970" "0.902" "0.955" "0.980" "0.735" "0.665" "0.765" "1.332" "15771.3" "15440.5" "15295.7" "14228.5" "15061.0" "15455.8" "11595.4" "10483.1" "12072.6" "21001.3" "" "" "" "" "" "" "" "" "" "" "8350.9" "8560.6" "8759.8" "6552.7" "8148.6" "8597.2" "6824.3" "5722.2" "6772.4" "21001.3" "70" "70" "70" "70" "70" "70" "70" "70" "70" "70" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3650651295291502810" "False" "High" "IsMasterProtein" "O75369" "Filamin-B OS=Homo sapiens OX=9606 GN=FLNB PE=1 SV=2" "0.000" "False" "371.171" "31" "72" "144" "63" "2602" "278.0" "5.73" "407.56" "72" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00630" "2317" "ENSG00000136068" "FLNB" "B2ZZ83; B2ZZ84; B2ZZ85; C9JKE6; C9JMC4; hsa:2317; O75369; Q13706; Q59EC2; Q60FE7; Q6MZJ1; Q8WXS9; Q8WXT0; Q8WXT1; Q8WXT2; Q8WXT3; Q9NRB5; Q9NT26; Q9UEV9" "Focal adhesion; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Ebola virus infection in host; NPHP1 deletion syndrome" "ISG15 antiviral mechanism" "6" "8" "1.006" "1.042" "1.025" "0.980" "0.990" "0.927" "1.003" "0.991" "0.763" "13256.1" "13340.7" "13818.5" "13582.3" "12991.0" "13117.0" "12285.1" "13300.7" "13135.1" "10112.1" "" "" "" "" "" "" "" "" "" "" "7019.1" "7396.5" "7913.8" "6255.1" "7028.7" "7296.3" "7230.2" "7260.2" "7368.5" "10112.1" "56" "56" "56" "56" "56" "56" "56" "56" "56" "56" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2962281166201317424" "False" "High" "IsMasterProtein" "P35579" "Myosin-9 OS=Homo sapiens OX=9606 GN=MYH9 PE=1 SV=4" "0.000" "False" "363.042" "37" "74" "195" "66" "1960" "226.4" "5.60" "519.08" "74" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00063, Pf01576, Pf02736" "4627" "ENSG00000100345" "MYH9" "A8K6E4; hsa:4627; O60805; P35579; Q60FE2; Q86T83" "Primary focal segmental glomerulosclerosis (FSGS); VEGFA-VEGFR2 signaling; Nephrotic syndrome; HDAC6 interactions in the central nervous system" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Signaling by ALK fusions and activated point mutants; RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs; CD163 mediating an anti-inflammatory response" "17" "7" "0.997" "1.010" "0.998" "1.009" "0.983" "0.902" "0.951" "0.922" "0.575" "20382.7" "20324.9" "20596.5" "20342.7" "20565.2" "20037.2" "18385.9" "19390.0" "18796.8" "11725.6" "" "" "" "" "" "" "" "" "" "" "10792.6" "11268.7" "11795.5" "9368.5" "11126.6" "11145.6" "10820.7" "10584.1" "10544.5" "11725.6" "62" "62" "62" "62" "62" "62" "62" "62" "62" "62" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-66753491464337277" "False" "High" "IsMasterProtein" "Q13813" "Spectrin alpha chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTAN1 PE=1 SV=3" "0.000" "False" "315.636" "29" "68" "105" "68" "2472" "284.4" "5.35" "313.84" "68" "cell organization and biogenesis" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf00435, Pf08726, Pf13499" "6709" "ENSG00000197694" "SPTAN1" "hsa:6709; Q13186; Q13813; Q15324; Q16606; Q59EF1; Q5VXV5; Q5VXV6; Q7Z6M5; Q9P0V0" "Fas ligand pathway and stress induction of heat shock proteins" "Neutrophil degranulation; RHOV GTPase cycle; COPI-mediated anterograde transport; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHOU GTPase cycle; Nephrin family interactions; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; Caspase-mediated cleavage of cytoskeletal proteins" "12" "0" "0.993" "0.980" "1.075" "1.083" "1.107" "1.322" "1.338" "1.299" "0.720" "9047.9" "8986.8" "8871.4" "9723.8" "9795.6" "10020.0" "11957.5" "12103.9" "11757.2" "6515.4" "" "" "" "" "" "" "" "" "" "" "4790.9" "4982.5" "5080.6" "4478.1" "5299.8" "5573.6" "7037.4" "6607.0" "6595.5" "6515.4" "45" "45" "45" "45" "45" "45" "45" "45" "45" "45" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8201100139023696608" "False" "High" "IsMasterProtein" "Q02952" "A-kinase anchor protein 12 OS=Homo sapiens OX=9606 GN=AKAP12 PE=1 SV=4" "0.000" "False" "287.094" "37" "51" "75" "51" "1782" "191.4" "4.41" "241.56" "51" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf03832, Pf10522" "9590" "ENSG00000131016" "AKAP12" "hsa:9590; O00310; O00498; Q02952; Q4LE68; Q5SZ80; Q5TGN1; Q68D82; Q99970" "G protein signaling pathways" "RHOD GTPase cycle; RHOF GTPase cycle" "3" "0" "0.960" "1.028" "0.952" "0.950" "0.947" "0.999" "1.146" "1.091" "0.521" "9334.1" "8957.1" "9591.4" "8888.7" "8865.5" "8843.2" "9321.9" "10692.6" "10185.1" "4862.7" "" "" "" "" "" "" "" "" "" "" "4942.4" "4966.1" "5493.0" "4093.5" "4796.6" "4919.0" "5486.2" "5836.6" "5713.6" "4862.7" "39" "39" "39" "39" "39" "39" "39" "39" "39" "39" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2305783293341844831" "False" "High" "IsMasterProtein" "Q14204" "Cytoplasmic dynein 1 heavy chain 1 OS=Homo sapiens OX=9606 GN=DYNC1H1 PE=1 SV=5" "0.000" "False" "287.076" "15" "70" "107" "70" "4646" "532.1" "6.40" "306.97" "70" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf03028, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781, Pf17852, Pf18198, Pf18199" "1778" "ENSG00000197102" "DYNC1H1" "B0I1R0; hsa:1778; Q14204; Q6DKQ7; Q8WU28; Q92814; Q9Y4G5" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption; PAFAH1B1 copy number variation" "Separation of Sister Chromatids; Neutrophil degranulation; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; COPI-mediated anterograde transport; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "24" "0" "1.009" "0.968" "0.976" "0.980" "0.975" "0.844" "0.798" "0.799" "0.986" "9714.1" "9798.2" "9398.7" "9481.9" "9522.8" "9467.4" "8199.2" "7753.9" "7759.8" "9575.2" "" "" "" "" "" "" "" "" "" "" "5143.6" "5432.4" "5382.6" "4366.7" "5152.2" "5266.2" "4825.5" "4232.5" "4353.1" "9575.2" "54" "54" "54" "54" "54" "54" "54" "54" "54" "54" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5950667386624240413" "False" "High" "IsMasterProtein" "Q01082" "Spectrin beta chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTBN1 PE=1 SV=2" "0.000" "False" "257.803" "26" "60" "95" "59" "2364" "274.4" "5.57" "260.35" "60" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00307, Pf00435" "6711" "ENSG00000115306" "SPTBN1" "B2RP63; hsa:6711; O60837; Q01082; Q16057; Q53R99; Q59ER3; Q8IX99" "TGF-beta signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "RHOV GTPase cycle; RHOU GTPase cycle; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; COPI-mediated anterograde transport; Nephrin family interactions; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; Signaling by FLT3 fusion proteins" "12" "1" "1.002" "0.968" "1.076" "1.091" "1.078" "1.271" "1.334" "1.285" "0.799" "7624.1" "7636.8" "7377.4" "8202.9" "8320.1" "8215.5" "9688.3" "10173.2" "9796.3" "6091.0" "" "" "" "" "" "" "" "" "" "" "4037.0" "4234.0" "4225.0" "3777.7" "4501.5" "4569.8" "5701.9" "5553.1" "5495.5" "6091.0" "44" "44" "44" "44" "44" "44" "44" "44" "44" "44" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2220837361715177214" "False" "High" "IsMasterProtein" "P08238" "Heat shock protein HSP 90-beta OS=Homo sapiens OX=9606 GN=HSP90AB1 PE=1 SV=4" "0.000" "False" "227.059" "44" "34" "197" "19" "724" "83.2" "5.03" "588.48" "34" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00183, Pf13589" "3326" "ENSG00000096384" "HSP90AB1" "B2R5P0; hsa:3326; P08238; Q5T9W7; Q9NQW0; Q9NTK6" "Nuclear receptors meta-pathway; NRF2 pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; Potential therapeutics for SARS; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Aryl hydrocarbon receptor signalling; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; DDX58/IFIH1-mediated induction of interferon-alpha/beta; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; RHOBTB2 GTPase cycle; Chaperone Mediated Autophagy; HSF1 activation; Attenuation phase; Uptake and function of diphtheria toxin; Assembly and release of respiratory syncytial virus (RSV) virions; Respiratory syncytial virus genome replication" "25" "12" "1.007" "1.013" "1.012" "1.003" "1.013" "0.818" "0.842" "0.856" "0.992" "15679.6" "15789.2" "15878.7" "15860.6" "15723.3" "15885.5" "12828.4" "13207.6" "13421.4" "15557.5" "" "" "" "" "" "" "" "" "" "" "8302.4" "8754.0" "9093.7" "7304.3" "8506.9" "8836.2" "7549.9" "7209.4" "7529.1" "15557.5" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6252367434931231115" "False" "High" "IsMasterProtein" "P49327" "Fatty acid synthase OS=Homo sapiens OX=9606 GN=FASN PE=1 SV=3" "0.000" "False" "216.120" "19" "46" "106" "45" "2511" "273.3" "6.44" "298.11" "46" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00107, Pf00109, Pf00550, Pf00698, Pf00975, Pf02801, Pf08242, Pf08659, Pf16197, Pf21089, Pf21149" "2194" "ENSG00000169710" "FASN" "hsa:2194; P49327; Q13479; Q16702; Q4LE83; Q6P4U5; Q6SS02; Q969R1; Q96C68; Q96IT0" "AMP-activated protein kinase signaling; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; FOXA2 pathway" "ChREBP activates metabolic gene expression; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; Vitamin B5 (pantothenate) metabolism" "18" "0" "0.993" "0.945" "0.960" "0.979" "0.975" "0.902" "0.821" "0.847" "1.218" "6565.3" "6518.7" "6207.1" "6301.8" "6430.4" "6404.3" "5922.4" "5390.9" "5559.1" "7997.0" "" "" "" "" "" "" "" "" "" "" "3476.3" "3614.1" "3554.8" "2902.2" "3479.1" "3562.4" "3485.5" "2942.7" "3118.5" "7997.0" "37" "37" "37" "37" "37" "37" "37" "37" "37" "37" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7449371538365957033" "False" "High" "IsMasterProtein" "P12270" "Nucleoprotein TPR OS=Homo sapiens OX=9606 GN=TPR PE=1 SV=3" "0.000" "False" "211.637" "21" "48" "68" "47" "2363" "267.1" "5.02" "207.43" "48" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf07926" "7175" "ENSG00000047410" "TPR" "hsa:7175; P12270; Q15624; Q15655; Q5SWY0; Q99968" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signaling by ALK fusions and activated point mutants" "29" "0" "1.039" "1.021" "1.055" "1.067" "1.105" "1.296" "1.262" "1.388" "2.134" "5674.0" "5897.5" "5794.2" "5983.3" "6054.2" "6271.6" "7355.7" "7163.2" "7873.1" "12110.5" "" "" "" "" "" "" "" "" "" "" "3004.4" "3269.7" "3318.3" "2755.5" "3275.6" "3488.6" "4329.1" "3910.0" "4416.6" "12110.5" "35" "35" "35" "35" "35" "35" "35" "35" "35" "35" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-823981804521467878" "False" "High" "IsMasterProtein" "P46013" "Proliferation marker protein Ki-67 OS=Homo sapiens OX=9606 GN=MKI67 PE=1 SV=2" "0.000" "False" "202.065" "18" "47" "65" "47" "3256" "358.5" "9.45" "181.57" "47" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00498, Pf08065, Pf15276" "4288" "ENSG00000148773" "MKI67" "hsa:4288; P46013; Q5VWH2" "Primary focal segmental glomerulosclerosis (FSGS)" "" "1" "0" "1.043" "1.045" "1.386" "1.317" "1.229" "2.098" "2.302" "2.185" "1.169" "3995.5" "4168.4" "4175.2" "5538.1" "5264.0" "4910.4" "8384.3" "9198.4" "8731.9" "4669.0" "" "" "" "" "" "" "" "" "" "" "2115.6" "2311.1" "2391.1" "2550.5" "2848.0" "2731.4" "4934.4" "5021.0" "4898.4" "4669.0" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7065009906831580898" "False" "High" "IsMasterProtein" "P07900" "Heat shock protein HSP 90-alpha OS=Homo sapiens OX=9606 GN=HSP90AA1 PE=1 SV=5" "0.000" "False" "183.975" "39" "30" "187" "16" "732" "84.6" "5.02" "526.14" "30" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00183, Pf13589" "3320" "ENSG00000080824" "HSP90AA1" "A8K500; B3KPJ9; hsa:3320; P07900; Q2PP14; Q5CAQ6; Q5CAQ7; Q9BVQ5" "Nucleotide-binding oligomerization domain (NOD) pathway; TNF-alpha signaling pathway; Corticotropin-releasing hormone signaling pathway; Aryl hydrocarbon receptor pathway; Ebstein-Barr virus LMP1 signaling; Aryl hydrocarbon receptor pathway; Constitutive androstane receptor pathway; Pregnane X receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced AP-1 survival signaling; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Th17 cell differentiation pathway; HDAC6 interactions in the central nervous system" "Regulation of actin dynamics for phagocytic cup formation; Potential therapeutics for SARS; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; Neutrophil degranulation; vRNP Assembly; Estrogen-dependent gene expression; Regulation of necroptotic cell death; Interleukin-4 and Interleukin-13 signaling; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Sema3A PAK dependent Axon repulsion; DDX58/IFIH1-mediated induction of interferon-alpha/beta; PIWI-interacting RNA (piRNA) biogenesis; VEGFR2 mediated vascular permeability; RHOBTB2 GTPase cycle; Chaperone Mediated Autophagy; HSF1 activation; Attenuation phase; eNOS activation; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Uptake and function of diphtheria toxin; Constitutive Signaling by Overexpressed ERBB2; Assembly and release of respiratory syncytial virus (RSV) virions; Respiratory syncytial virus genome replication; Scavenging by Class F Receptors; Drug-mediated inhibition of ERBB2 signaling; Resistance of ERBB2 KD mutants to trastuzumab; Resistance of ERBB2 KD mutants to sapitinib; Resistance of ERBB2 KD mutants to tesevatinib; Resistance of ERBB2 KD mutants to neratinib; Resistance of ERBB2 KD mutants to osimertinib; Resistance of ERBB2 KD mutants to afatinib; Resistance of ERBB2 KD mutants to AEE788; Resistance of ERBB2 KD mutants to lapatinib; Drug resistance in ERBB2 TMD/JMD mutants" "71" "0" "1.032" "1.010" "1.016" "1.017" "1.026" "0.861" "0.863" "0.859" "0.945" "5859.4" "6047.9" "5919.7" "5951.0" "5956.7" "6014.3" "5045.0" "5054.6" "5031.8" "5534.3" "" "" "" "" "" "" "" "" "" "" "3102.5" "3353.1" "3390.2" "2740.6" "3222.8" "3345.4" "2969.1" "2759.1" "2822.7" "5534.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6514754949609892250" "False" "High" "IsMasterProtein" "Q9UQE7" "Structural maintenance of chromosomes protein 3 OS=Homo sapiens OX=9606 GN=SMC3 PE=1 SV=2" "0.000" "False" "178.069" "31" "38" "60" "38" "1217" "141.5" "7.18" "189.83" "38" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "9126" "ENSG00000108055" "SMC3" "A8K156; hsa:9126; O60464; Q5T482; Q9UQE7" "Cell cycle; Retinoblastoma gene in cancer; MECP2 and associated Rett syndrome; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; 10q22q23 copy number variation" "SUMOylation of DNA damage response and repair proteins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "15" "0" "1.023" "1.017" "0.929" "0.989" "0.994" "0.887" "0.911" "0.925" "0.800" "7214.1" "7382.3" "7334.0" "6699.7" "7135.4" "7169.5" "6396.2" "6573.2" "6670.1" "5769.5" "" "" "" "" "" "" "" "" "" "" "3819.8" "4092.9" "4200.2" "3085.4" "3860.5" "3988.0" "3764.3" "3588.0" "3741.8" "5769.5" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5619484675981056092" "False" "High" "IsMasterProtein" "P10809" "60 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPD1 PE=1 SV=2" "0.000" "False" "170.230" "58" "30" "115" "30" "573" "61.0" "5.87" "325.87" "30" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00118" "3329" "ENSG00000144381" "HSPD1" "B2R5M6; B7Z712; hsa:3329; P10809; Q38L19; Q9UCR6" "Apoptosis-related network due to altered Notch3 in ovarian cancer; 8p23.1 copy number variation syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways" "Mitochondrial protein import; Mitochondrial protein degradation; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation" "6" "0" "1.044" "0.988" "1.029" "1.004" "0.941" "0.953" "1.020" "0.924" "0.484" "8156.4" "8518.9" "8059.4" "8390.0" "8189.2" "7677.7" "7769.9" "8321.2" "7537.6" "3948.6" "" "" "" "" "" "" "" "" "" "" "4318.8" "4723.1" "4615.6" "3863.9" "4430.7" "4270.7" "4572.8" "4542.2" "4228.4" "3948.6" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4567547795878987385" "False" "High" "IsMasterProtein" "P21333" "Filamin-A OS=Homo sapiens OX=9606 GN=FLNA PE=1 SV=4" "0.000" "False" "165.411" "17" "38" "52" "30" "2647" "280.6" "6.06" "156.87" "38" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00307, Pf00630" "2316" "ENSG00000196924" "FLNA" "E9KL45; hsa:2316; P21333; Q5HY53; Q5HY55; Q8NF52" "Androgen receptor signaling pathway; Prolactin signaling pathway; Focal adhesion; Hypothesized pathways in pathogenesis of cardiovascular disease; MAPK signaling pathway; IL-4 signaling pathway; Ebola virus infection in host; Joubert syndrome; NPHP1 deletion syndrome" "OAS antiviral response; Platelet degranulation ; RHO GTPases activate PAKs; GP1b-IX-V activation signalling; Cell-extracellular matrix interactions" "14" "1" "1.034" "0.987" "1.043" "1.055" "1.022" "1.040" "0.956" "1.014" "1.784" "2871.6" "2970.2" "2834.8" "2995.5" "3030.7" "2935.3" "2987.3" "2743.8" "2912.2" "5122.8" "" "" "" "" "" "" "" "" "" "" "1520.5" "1646.8" "1623.5" "1379.5" "1639.7" "1632.7" "1758.1" "1497.7" "1633.7" "5122.8" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4357852675593899782" "False" "High" "IsMasterProtein" "P25205" "DNA replication licensing factor MCM3 OS=Homo sapiens OX=9606 GN=MCM3 PE=1 SV=3" "0.000" "False" "162.070" "40" "34" "84" "34" "808" "90.9" "5.77" "199.57" "34" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4172" "ENSG00000112118" "MCM3" "B4DWW4; hsa:4172; P25205; Q92660; Q9BTR3; Q9NUE7" "Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "11" "0" "0.989" "1.016" "0.982" "0.917" "0.930" "0.767" "0.862" "0.813" "0.686" "5151.5" "5092.8" "5232.5" "5059.8" "4721.9" "4788.6" "3950.9" "4442.1" "4189.8" "3531.9" "" "" "" "" "" "" "" "" "" "" "2727.7" "2823.6" "2996.7" "2330.2" "2554.7" "2663.6" "2325.2" "2424.8" "2350.4" "3531.9" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3453697574232543386" "False" "High" "IsMasterProtein" "O43707" "Alpha-actinin-4 OS=Homo sapiens OX=9606 GN=ACTN4 PE=1 SV=2" "0.000" "False" "159.535" "36" "30" "71" "21" "911" "104.8" "5.44" "184.58" "30" "cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00307, Pf00435, Pf08726" "81" "ENSG00000130402; ENSG00000282844" "ACTN4" "A4K467; D6PXK4; hsa:81; O43707; O76048" "Arrhythmogenic right ventricular cardiomyopathy; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Striated muscle contraction pathway; Ebola virus infection in host; Nephrotic syndrome; Alstrom syndrome" "Platelet degranulation ; Nephrin family interactions" "9" "7" "0.979" "0.991" "0.999" "1.003" "1.004" "1.012" "1.049" "1.016" "0.516" "4960.4" "4856.5" "4913.9" "4955.4" "4974.2" "4980.0" "5022.3" "5205.6" "5041.4" "2559.9" "" "" "" "" "" "" "" "" "" "" "2626.5" "2692.6" "2814.2" "2282.1" "2691.3" "2770.1" "2955.8" "2841.5" "2828.1" "2559.9" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5449770128653317074" "False" "High" "IsMasterProtein" "Cont_P15636" "Protease 1 OS=Achromobacter lyticus OX=224 PE=1 SV=1" "0.000" "True" "158.033" "19" "12" "224" "12" "653" "68.1" "7.24" "582.18" "12" "protein metabolism" "non-structural extracellular" "other molecular function" "Pf01483, Pf18911" "" "" "" "" "" "" "0" "0" "1.026" "1.017" "1.151" "1.030" "1.162" "1.006" "0.955" "0.972" "0.957" "8813.3" "9039.3" "8964.1" "10142.9" "9080.2" "10236.7" "8865.5" "8416.8" "8565.7" "8434.3" "" "" "" "" "" "" "" "" "" "" "4666.6" "5011.6" "5133.7" "4671.1" "4912.7" "5694.1" "5217.6" "4594.4" "4805.2" "8434.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6866488294459179487" "False" "High" "IsMasterProtein" "Q8NFC6" "Biorientation of chromosomes in cell division protein 1-like 1 OS=Homo sapiens OX=9606 GN=BOD1L1 PE=1 SV=2" "0.000" "False" "155.835" "14" "41" "48" "41" "3051" "330.3" "5.08" "132.68" "41" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "" "Pf05205" "259282" "ENSG00000038219" "BOD1L1" "hsa:259282; Q6P0M8; Q8NFC6; Q96AL1; Q9H6G0; Q9NTD6; Q9P2L9" "" "Formation of WDR5-containing histone-modifying complexes" "1" "0" "0.991" "1.070" "1.010" "1.026" "1.021" "1.010" "1.123" "1.066" "0.543" "5138.9" "5091.0" "5496.5" "5190.2" "5274.9" "5247.9" "5189.3" "5773.6" "5479.7" "2788.5" "" "" "" "" "" "" "" "" "" "" "2721.1" "2822.6" "3147.8" "2390.2" "2853.9" "2919.1" "3054.1" "3151.5" "3074.0" "2788.5" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-772083225745130744" "False" "High" "IsMasterProtein" "P11142" "Heat shock cognate 71 kDa protein OS=Homo sapiens OX=9606 GN=HSPA8 PE=1 SV=1" "0.000" "False" "150.112" "40" "27" "120" "16" "646" "70.9" "5.52" "349.74" "27" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00012" "3312" "ENSG00000109971" "HSPA8" "hsa:3312; P11142; Q9H3R6" "Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Exercise-induced circadian regulation; Measles virus infection; Opioid receptor pathways; Extrafollicular and follicular B cell activation by SARS-CoV-2; 1p36 copy number variation syndrome; HDAC6 interactions in the central nervous system" "AUF1 (hnRNP D0) binds and destabilizes mRNA; Neutrophil degranulation; mRNA Splicing - Major Pathway; Golgi Associated Vesicle Biogenesis; Late endosomal microautophagy; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; PKR-mediated signaling; Regulation of HSF1-mediated heat shock response; Lysosome Vesicle Biogenesis; Clathrin-mediated endocytosis; CHL1 interactions; Interleukin-4 and Interleukin-13 signaling; GABA synthesis, release, reuptake and degradation; Lipophagy; Chaperone Mediated Autophagy; Protein methylation; Attenuation phase; Respiratory syncytial virus genome transcription" "27" "8" "1.018" "1.013" "1.068" "1.044" "1.121" "1.016" "1.022" "1.012" "0.834" "8589.1" "8747.9" "8704.1" "9172.3" "8970.7" "9631.1" "8729.6" "8782.1" "8696.2" "7166.9" "" "" "" "" "" "" "" "" "" "" "4547.9" "4850.1" "4984.8" "4224.1" "4853.5" "5357.2" "5137.7" "4793.7" "4878.4" "7166.9" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8891268094734712955" "False" "High" "IsMasterProtein" "Q13428" "Treacle protein OS=Homo sapiens OX=9606 GN=TCOF1 PE=1 SV=3" "0.000" "False" "148.862" "25" "36" "60" "36" "1488" "152.0" "9.04" "162.16" "36" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf03546" "6949" "ENSG00000070814" "TCOF1" "A0JLU0; B4E111; hsa:6949; Q13428; Q6SC72; Q7Z5W9; Q96A52; Q99408; Q99860" "" "" "0" "0" "0.962" "1.005" "1.022" "0.980" "0.904" "0.978" "1.063" "1.031" "0.697" "5369.9" "5166.8" "5397.2" "5487.9" "5263.2" "4856.3" "5252.3" "5709.8" "5536.7" "3743.7" "" "" "" "" "" "" "" "" "" "" "2843.4" "2864.6" "3091.0" "2527.4" "2847.6" "2701.3" "3091.1" "3116.7" "3105.9" "3743.7" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1034815253104013464" "False" "High" "IsMasterProtein" "P50990" "T-complex protein 1 subunit theta OS=Homo sapiens OX=9606 GN=CCT8 PE=1 SV=4" "0.000" "False" "147.335" "48" "26" "87" "26" "548" "59.6" "5.60" "250.35" "26" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00118" "10694" "ENSG00000156261; ENSG00000291533" "CCT8" "A6NN54; B4DEM7; B4DQH4; hsa:10694; P50990; Q4VBP8" "16p11.2 proximal deletion syndrome" "Prefoldin mediated transfer of substrate to CCT/TriC; Neutrophil degranulation; Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Folding of actin by CCT/TriC" "8" "0" "1.011" "1.002" "1.007" "1.009" "1.013" "0.998" "1.005" "0.986" "0.628" "6933.9" "7007.4" "6948.9" "6979.5" "6995.1" "7024.9" "6917.9" "6971.8" "6836.6" "4356.9" "" "" "" "" "" "" "" "" "" "" "3671.5" "3885.1" "3979.6" "3214.3" "3784.6" "3907.6" "4071.4" "3805.6" "3835.2" "4356.9" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "682895518506643546" "False" "High" "IsMasterProtein" "P11021" "Endoplasmic reticulum chaperone BiP OS=Homo sapiens OX=9606 GN=HSPA5 PE=1 SV=2" "0.000" "False" "145.798" "37" "25" "72" "23" "654" "72.3" "5.16" "218.34" "25" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "translation activity;other molecular function" "Pf00012" "3309" "ENSG00000044574" "HSPA5" "B0QZ61; hsa:3309; P11021; Q2EF78; Q9NPF1; Q9UK02" "Parkin-ubiquitin proteasomal system pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Photodynamic therapy-induced unfolded protein response; Prion disease pathway; Unfolded protein response; Orexin receptor pathway" "Regulation of HSF1-mediated heat shock response; Platelet degranulation ; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; ATF6B (ATF6-beta) activates chaperones; IRE1alpha activates chaperones; PERK regulates gene expression; ATF6 (ATF6-alpha) activates chaperone genes" "14" "0" "0.965" "0.998" "0.998" "0.997" "0.996" "0.905" "0.986" "0.964" "0.732" "4663.8" "4502.8" "4655.1" "4655.6" "4650.7" "4645.1" "4220.6" "4597.9" "4497.4" "3415.3" "" "" "" "" "" "" "" "" "" "" "2469.5" "2496.5" "2665.9" "2144.0" "2516.2" "2583.8" "2484.0" "2509.8" "2523.0" "3415.3" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3819136565778515185" "False" "High" "IsMasterProtein" "P13639" "Elongation factor 2 OS=Homo sapiens OX=9606 GN=EEF2 PE=1 SV=4" "0.000" "False" "145.739" "32" "27" "110" "26" "858" "95.3" "6.83" "314.64" "27" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" "1938" "ENSG00000167658" "EEF2" "A0A384N6H1; B2RMP5; D6W618; hsa:1938; P13639; Q58J86" "Translation factors; AMP-activated protein kinase signaling; Brain-derived neurotrophic factor (BDNF) signaling pathway; IL-18 signaling pathway" "Neutrophil degranulation; Protein methylation; Uptake and function of diphtheria toxin; Peptide chain elongation; Synthesis of diphthamide-EEF2" "9" "1" "1.052" "1.031" "1.045" "1.057" "1.066" "1.062" "1.131" "1.073" "0.584" "9783.5" "10292.4" "10086.2" "10220.7" "10340.4" "10432.3" "10394.8" "11065.4" "10496.7" "5714.7" "" "" "" "" "" "" "" "" "" "" "5180.3" "5706.4" "5776.4" "4707.0" "5594.6" "5802.9" "6117.6" "6040.1" "5888.4" "5714.7" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2015185769260426388" "False" "High" "IsMasterProtein" "P53396" "ATP-citrate synthase OS=Homo sapiens OX=9606 GN=ACLY PE=1 SV=3" "0.000" "False" "142.953" "28" "31" "74" "31" "1101" "120.8" "7.33" "224.14" "31" "other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00285, Pf00549, Pf02629, Pf16114" "47" "ENSG00000131473" "ACLY" "B4DIM0; B4E3P0; hsa:47; P53396; Q13037; Q9BRL0" "Sterol regulatory element-binding proteins (SREBP) signaling; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Fatty acid biosynthesis; Amino acid metabolism; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer" "Neutrophil degranulation; ChREBP activates metabolic gene expression; Fatty acyl-CoA biosynthesis" "10" "0" "0.952" "0.955" "0.937" "0.962" "0.952" "0.843" "0.826" "0.842" "0.641" "8003.3" "7622.6" "7642.9" "7502.7" "7696.0" "7622.5" "6747.0" "6607.8" "6741.1" "5131.5" "" "" "" "" "" "" "" "" "" "" "4237.8" "4226.2" "4377.1" "3455.2" "4163.9" "4240.0" "3970.8" "3606.9" "3781.6" "5131.5" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5530158233237029042" "False" "High" "IsMasterProtein" "Q15075" "Early endosome antigen 1 OS=Homo sapiens OX=9606 GN=EEA1 PE=1 SV=2" "0.000" "False" "142.049" "23" "32" "43" "32" "1411" "162.4" "5.68" "134.95" "32" "cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363" "8411" "ENSG00000102189" "EEA1" "hsa:8411; Q14221; Q15075" "VEGFA-VEGFR2 signaling" "Toll Like Receptor 9 (TLR9) Cascade" "2" "0" "1.040" "1.075" "0.996" "0.971" "0.962" "1.048" "1.191" "1.111" "0.589" "5522.4" "5741.2" "5936.4" "5499.7" "5360.3" "5311.7" "5785.1" "6576.9" "6136.7" "3254.9" "" "" "" "" "" "" "" "" "" "" "2924.1" "3183.1" "3399.8" "2532.8" "2900.1" "2954.6" "3404.7" "3590.0" "3442.5" "3254.9" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4615289327887409645" "False" "High" "IsMasterProtein" "Q9Y490" "Talin-1 OS=Homo sapiens OX=9606 GN=TLN1 PE=1 SV=3" "0.000" "False" "139.960" "14" "35" "42" "35" "2541" "269.6" "6.07" "132.70" "35" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00373, Pf01608, Pf08913, Pf09141, Pf16511, Pf21692" "7094" "ENSG00000137076" "TLN1" "A0A1S5UZ07; A6NMY0; hsa:7094; Q86YD0; Q9NZQ2; Q9UHH8; Q9UPX3; Q9Y490" "Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; TROP2 regulatory signaling" "Platelet degranulation ; Signaling by BRAF and RAF1 fusions; XBP1(S) activates chaperone genes; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Smooth Muscle Contraction; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins" "18" "0" "1.033" "0.991" "1.020" "1.038" "1.063" "1.069" "0.794" "1.143" "4.550" "2937.7" "3034.8" "2911.2" "2995.1" "3049.5" "3121.7" "3140.5" "2332.8" "3356.8" "13365.0" "" "" "" "" "" "" "" "" "" "" "1555.5" "1682.6" "1667.2" "1379.4" "1649.9" "1736.4" "1848.3" "1273.3" "1883.1" "13365.0" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6210925912035566058" "False" "High" "IsMasterProtein" "Q14980" "Nuclear mitotic apparatus protein 1 OS=Homo sapiens OX=9606 GN=NUMA1 PE=1 SV=2" "0.000" "False" "139.247" "14" "27" "35" "27" "2115" "238.1" "5.78" "117.51" "27" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf21670" "4926" "ENSG00000137497" "NUMA1" "H0YH75; hsa:4926; Q14980; Q14981; Q9BTE9" "Ectoderm differentiation; Ectoderm differentiation; 8p23.1 copy number variation syndrome" "Recruitment of NuMA to mitotic centrosomes; Mitotic Prophase" "5" "0" "1.003" "1.004" "1.208" "1.135" "1.100" "1.821" "1.711" "1.812" "3.484" "1590.0" "1594.8" "1597.0" "1920.6" "1804.4" "1748.7" "2895.2" "2719.9" "2881.5" "5540.0" "" "" "" "" "" "" "" "" "" "" "841.9" "884.2" "914.6" "884.5" "976.2" "972.7" "1703.9" "1484.7" "1616.5" "5540.0" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5005343800474254733" "False" "High" "IsMasterProtein" "P13796" "Plastin-2 OS=Homo sapiens OX=9606 GN=LCP1 PE=1 SV=6" "0.000" "False" "138.692" "44" "23" "83" "21" "627" "70.2" "5.43" "219.58" "23" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00036, Pf00307" "3936" "ENSG00000136167" "LCP1" "B2R613; B4DUA0; hsa:3936; P13796; Q5TBN4" "" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "1" "2" "0.997" "1.003" "1.010" "1.030" "1.025" "0.999" "1.049" "1.014" "0.556" "5109.8" "5094.3" "5124.1" "5158.4" "5265.0" "5235.3" "5106.4" "5361.2" "5179.6" "2842.4" "" "" "" "" "" "" "" "" "" "" "2705.6" "2824.4" "2934.5" "2375.6" "2848.6" "2912.1" "3005.3" "2926.4" "2905.6" "2842.4" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8293079878251606526" "False" "High" "IsMasterProtein" "P14625" "Endoplasmin OS=Homo sapiens OX=9606 GN=HSP90B1 PE=1 SV=1" "0.000" "False" "137.754" "34" "26" "67" "25" "803" "92.4" "4.84" "199.65" "26" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00183, Pf13589" "7184" "ENSG00000166598" "HSP90B1" "hsa:7184; P14625; Q96A97" "Photodynamic therapy-induced unfolded protein response; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prion disease pathway; PI3K-Akt signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Interleukin-4 and Interleukin-13 signaling; Trafficking and processing of endosomal TLR; Scavenging by Class A Receptors; ATF6 (ATF6-alpha) activates chaperone genes" "11" "0" "0.999" "1.018" "0.998" "1.007" "0.983" "0.905" "0.904" "0.907" "0.765" "4775.9" "4772.7" "4862.5" "4766.5" "4808.4" "4695.7" "4321.9" "4318.6" "4329.5" "3652.4" "" "" "" "" "" "" "" "" "" "" "2528.8" "2646.1" "2784.8" "2195.1" "2601.5" "2611.9" "2543.6" "2357.3" "2428.8" "3652.4" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-174490317750568225" "False" "High" "IsMasterProtein" "Cont_P60712" "Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1" "0.000" "True" "136.583" "46" "18" "303" "6" "375" "41.7" "5.48" "821.50" "18" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "100011313; 100011351; 100033878; 100078865; 100135470; 100173832; 100303677; 100654618; 100689477; 100919051; 101026869; 101098507; 101375328; 101813373; 101844587; 101941176; 101958638; 102030392; 102041442; 102067189; 102179831; 102286048; 102386754; 102744309; 102772396; 102884469; 103050159; 103077223; 103115297; 103197222; 105077471; 105294565; 105497365; 105551087; 105719490; 105868294; 105990935; 106497948; 107155983; 107515934; 108496585; 108538237; 109314696; 109380220; 109700700; 11461; 280979; 396526; 403580; 414396; 443052; 450133; 574285; 60; 81822" "ENSABRG00000002004; ENSACOG00000001373; ENSACUG00000014525; ENSAMEG00000019137; ENSAMEG00000025519; ENSAMEG00000030859; ENSANAG00000024575; ENSAPLG00020013590; ENSBIXG00000014387; ENSBIXG00005017151; ENSBJAG00000012824; ENSBOBG00000008860; ENSBTAG00000026199; ENSCABG00000005869; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCAFG00805000771; ENSCCEG00000022540; ENSCCNG00000030119; ENSCGRG00001015781; ENSCHIG00000013316; ENSCJAG00000074750; ENSCJAG00000083114; ENSCLAG00000013196; ENSCMUG00000004054; ENSCPBG00000020809; ENSCPGG00000001752; ENSCPOG00000013467; ENSCPRG00005016203; ENSCPVG00000014059; ENSCSRG00000014125; ENSCUSG00005013766; ENSDLEG00000020930; ENSFALG00000013828; ENSFCAG00000006788; ENSFTIG00000005623; ENSG00000075624; ENSGAGG00000004381; ENSGEVG00005007981; ENSGGOG00000001133; ENSJHYG00000006128; ENSJJAG00000018929; ENSLCNG00005020599; ENSMCSG00000014736; ENSMICG00000002791; ENSMLEG00000038914; ENSMMMG00000007553; ENSMMNG00015004465; ENSMMSG00000018023; ENSMMUG00000011153; ENSMNEG00000033949; ENSMODG00000002647; ENSMPUG00000016612; ENSMUGG00000013478; ENSMUNG00000007311; ENSMUSG00000029580; ENSNVIG00000005620; ENSOANG00000007716; ENSOARG00020008714; ENSOSUG00000006211; ENSPANG00000015700; ENSPCEG00000013440; ENSPCLG00000014414; ENSPCTG00005017252; ENSPEMG00000012952; ENSPLOG00000015512; ENSPPYG00000017336; ENSPSTG00000003558; ENSPTEG00000021167; ENSPTRG00000018890; ENSPTXG00000006649; ENSRBIG00000014104; ENSRFEG00010011816; ENSRNOG00000034254; ENSRNOG00055011660; ENSRNOG00060020294; ENSRNOG00065000139; ENSSBOG00000033859; ENSSHAG00000029431; ENSSHBG00005009495; ENSSOCG00000011957; ENSSSCG00000007585; ENSSSCG00005020690; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSUG00005004355; ENSSTOG00000014797; ENSSVLG00005024720; ENSTGEG00000001941; ENSTMTG00000013939; ENSVKKG00000006783; ENSVURG00010018277; ENSZALG00000007655; ENSZLMG00000002642" "Actb; ACTB; Actb_0; ACTL8; LOC101872991; LOC106497948; LOC111145734; LOC112063645; LOC117800408; LOC118142876; PS1TP5BP1" "A0A096NAA6; A0A098M1X5; A0A0B6VJU7; A0A0B8RRU9; A0A0B8RTY2; A0A1D9CFN7; A0A1S2ZVA4; A0A1S3FRD3; A0A1U7Q273; A0A1W7RJQ3; A0A218UWT5; A0A226NJ42; A0A250YGN4; A0A2D4GG12; A0A2J8KJN5; A0A2J8RAH6; A0A2K5CXD5; A0A2K5ZNV7; A0A2K6C9L8; A0A2K6JVX9; A0A2K6UUH3; A0A2P4SFV3; A0A2U3VHD6; A0A2U3XSJ3; A0A2Y9GE45; A0A2Y9JFQ8; A0A2Y9MFS3; A0A2Y9S868; A0A340WEU6; A0A341CY14; A0A384AHN3; A0A3Q7NCZ0; A0A452EGB1; A0A452GTY2; A0A4D9ENE9; A0A4W2DYQ2; A0A4X2LSI7; A0A5E4C6E9; A0A5J5MXV1; A0A5N3VUL9; A0A5N4CXK3; A0A663NBJ0; A0A667IZV1; A0A669QC85; A0A670YBF6; A0A671EW41; A0A672U7D6; A0A673TCM5; A0A674JEF6; A0A6B0SBF2; A0A6B2F1I3; A0A6B2FBI6; A0A6I9HGD1; A0A6J0H3K7; A0A6J0VYA4; A0A6J1Y0U5; A0A6J2ER79; A0A6J2G0V3; A0A6J2MYQ0; A0A6J3AFQ7; A0A6J3DTG2; A0A6J3GBY8; A0A6J3PXY9; A0A6P3QDF4; A0A6P5M7F0; A0A6P5PSI5; A0A6P9D9Q3; A0A7J7X8Z4; A0A7J8FJ79; A0A7J8I7K0; A0A7K4LHI1; A0A7K4PGF5; A0A7K4QS53; A0A7K4T128; A0A7K4TT29; A0A7K4VIP3; A0A7K4WM66; A0A7K4XNG5; A0A7K4Z9S9; A0A7K5AA34; A0A7K5AS89; A0A7K5BQ55; A0A7K5FSS5; A0A7K5H4P8; A0A7K5I2U8; A0A7K5K1W1; A0A7K5L347; A0A7K5MV66; A0A7K5NYG3; A0A7K5PUR4; A0A7K5QKD4; A0A7K5SEW2; A0A7K5SN56; A0A7K5UCA8; A0A7K5V0T3; A0A7K5W0A4; A0A7K5XZZ2; A0A7K5YRX7; A0A7K5ZQ33; A0A7K6AXY2; A0A7K6BYL2; A0A7K6FAZ8; A0A7K6H213; A0A7K6K8T2; A0A7K6M1I6; A0A7K6NUL4; A0A7K6QDF5; A0A7K6RH22; A0A7K6TM80; A0A7K6VD36; A0A7K6W7N1; A0A7K6X5J8; A0A7K6YU38; A0A7K7C2G9; A0A7K7EJS7; A0A7K7FS46; A0A7K7GD18; A0A7K7IBW8; A0A7K7K4W1; A0A7K7KKG3; A0A7K7MQH8; A0A7K7MV68; A0A7K7PD37; A0A7K7QM76; A0A7K7SE36; A0A7K7SKG2; A0A7K7VCN0; A0A7K7W887; A0A7K7XYY4; A0A7K7YKB8; A0A7K8CFW2; A0A7K8EJC7; A0A7K8FS78; A0A7K8G222; A0A7K8IUQ2; A0A7K8JZV4; A0A7K8LPI3; A0A7K8NBM6; A0A7K8PNA5; A0A7K8Q6L8; A0A7K8RIG2; A0A7K8SZY6; A0A7K8UAQ8; A0A7K8VV48; A0A7K8WC57; A0A7K8XP00; A0A7K8YCU6; A0A7K9A6Q1; A0A7K9CAW4; A0A7K9CTY4; A0A7K9E1U2; A0A7K9FBL7; A0A7K9GU20; A0A7K9HIF7; A0A7K9J0P9; A0A7K9JQ87; A0A7K9LVG6; A0A7K9R4T1; A0A7K9RUC2; A0A7K9T1K6; A0A7K9TJU9; A0A7K9VM54; A0A7K9W8F9; A0A7K9XJP5; A0A7K9YTX8; A0A7L0B981; A0A7L0CFC2; A0A7L0DK08; A0A7L0EE55; A0A7L0FB96; A0A7L0GQU8; A0A7L0IUJ7; A0A7L0K254; A0A7L0L680; A0A7L0MVK5; A0A7L0NBG6; A0A7L0Q6H1; A0A7L0RLK8; A0A7L0TBQ4; A0A7L0UF87; A0A7L0WJD4; A0A7L0ZXX6; A0A7L1D3E3; A0A7L1EEL1; A0A7L1EWI9; A0A7L1GDD0; A0A7L1I1H5; A0A7L1IUB6; A0A7L1K0S4; A0A7L1L6I1; A0A7L1MJS1; A0A7L1N7E9; A0A7L1QY43; A0A7L1R9N1; A0A7L1TFJ1; A0A7L1USL1; A0A7L1X2N1; A0A7L1YHH8; A0A7L1ZA36; A0A7L2AFK2; A0A7L2CBA6; A0A7L2DI04; A0A7L2E5K5; A0A7L2ETQ7; A0A7L2GZ90; A0A7L2HLP4; A0A7L2JI84; A0A7L2K9F9; A0A7L2LSR8; A0A7L2MKA1; A0A7L2NWG1; A0A7L2Q5Z6; A0A7L2TKF5; A0A7L2UQP2; A0A7L2WPM1; A0A7L3AB48; A0A7L3AEQ2; A0A7L3CBV1; A0A7L3GBT6; A0A7L3H4H6; A0A7L3I6Y5; A0A7L3KV16; A0A7L3L3C1; A0A7L3M5B9; A0A7L3NFE1; A0A7L3PPT4; A0A7L3QID2; A0A7L3RPI2; A0A7L3ST79; A0A7L3U378; A0A7L3VAR1; A0A7L3W396; A0A7L3X8C9; A0A7L3Z0M0; A0A7L4AJ46; A0A7L4BIP7; A0A7L4CC84; A0A7L4DQB0; A0A7L4EP40; A0A7L4HN55; A0A7L4J9W9; A0A7M4FIE6; A0A7N4PW14; A0A7T6ZK12; A0A811Z8F1; A0A850TFQ9; A0A850V5R2; A0A850W4N7; A0A850XKN3; A0A850YK23; A0A851A5U4; A0A851B4R4; A0A851CTC7; A0A851D320; A0A851E8C6; A0A851F1A8; A0A851JVZ7; A0A851K2P6; A0A851LU60; A0A851P5P0; A0A851R2P6; A0A851S6S6; A0A851T4V4; A0A851U0I3; A0A851VRP0; A0A851WCV5; A0A851Y321; A0A851Z9B4; A0A852A4Z3; A0A852AR86; A0A852BQ86; A0A852DLV7; A0A852E4W4; A0A852G2S2; A0A852L7H9; A0A852LWU6; A0A852MIU4; A0A852P924; A0A8B6ZZ93; A0A8B7FY80; A0A8B7JWS2; A0A8B7QXR8; A0A8B8VBY0; A0A8B9BC47; A0A8B9EY57; A0A8B9TCS0; A0A8C0BMH3; A0A8C0GIN8; A0A8C0IEG6; A0A8C0VMY6; A0A8C2VXZ2; A0A8C3I6V8; A0A8C3J5G4; A0A8C3QCS8; A0A8C3SWN5; A0A8C3V1H9; A0A8C4U9L8; A0A8C4W3F9; A0A8C5IQ83; A0A8C5L3Y8; A0A8C5UI70; A0A8C5Z473; A0A8C6AVT7; A0A8C6E309; A0A8C6J2B6; A0A8C7ELL8; A0A8C8AQ23; A0A8C8SAX1; A0A8C8TJI2; A0A8C9D802; A0A8C9EU06; A0A8C9HDT2; A0A8D0FEG6; A0A8D2DXS1; A0A8D2E312; A0A8D2J5F6; A0A8D2QDJ6; A0A8D2QMT1; A0A8I3W1I0; A0A8J4I2Z8; A0A8J4N6K5; A0A8J4NKS0; A0A8J4P196; A0A8J4U9Z8; A0A8K0BW04; A0A8K1GFZ5; A0A8M1G7Q7; A0A8S9EM85; A0A8V5H9G0; A0A973YLC1; A0A9F2R4N2; A0A9W2UUK2; A0A9W3F4H2; A0AA35L9Q0; A0AA40H6S4; A0AA40LS06; A5D961; A5PKA1; A6K1N6; aam:106497948; aful:116495117; aju:106984514; asn:102386754; B2RRX1; bacu:103015338; bom:102286048; bta:280979; ccan:109700700; cfa:403580; cfr:102514032; cpic:101941176; cpoc:100135470; cpoo:109314696; D5MU85; D7RIF5; dle:111170344; dord:105990935; ecb:100033878; elk:111145734; F6TIK4; F6UDX9; F7DIB7; fab:101813373; fca:101098507; G1MLH3; G3GVD0; G3QFP0; G8HY07; gfr:102041442; gga:396526; hai:109380220; hsa:60; I3MNL1; J3S3X5; J7H0T4; L5L2F8; L5LSF7; lav:100654618; lve:103077223; lww:102744309; M3WRZ7; M3YYU9; M7B7E7; maua:101844587; mcal:110295381; mcc:574285; mdo:100011313; mdo:100011351; mleu:105551087; mmu:11461; mmur:105868294; mni:105497365; mpuf:101686268; myd:102772396; nasi:112412020; nsu:110572001; O18840; oaa:100078865; oro:101375328; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pale:102884469; panu:101026869; pbi:103050159; pcad:112063645; pcw:110223114; pdic:114509151; pgut:117676791; pon:100173832; ptr:450133; pvp:105294565; Q11209; Q11211; Q1KLZ0; Q25PW9; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q58J72; Q5R1X3; Q5R582; Q5R6G0; Q5W9H6; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; R0LHA7; ray:107515934; rbb:108538237; rno:81822; S9YTS3; sbq:101037287; shr:100919051; ssc:414396; T1DP26; U3FXK3; U3KHC4; umr:103670086; V9P8F4; vpc:102534524; zab:102067189; zca:113932833" "FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling pathway; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; RHO GTPases activate IQGAPs; Cell-extracellular matrix interactions; MAP2K and MAPK activation; VEGFA-VEGFR2 Pathway; UCH proteinases; Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Clathrin-mediated endocytosis; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; UCH proteinases; RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; EPHB-mediated forward signaling; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; RHOF GTPase cycle; B-WICH complex positively regulates rRNA expression; EPHB-mediated forward signaling; Factors involved in megakaryocyte development and platelet production; EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by RAF1 mutants; Adherens junctions interactions; DNA Damage Recognition in GG-NER; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; RHO GTPases Activate Formins; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Adherens junctions interactions; VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; MAP2K and MAPK activation; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; RHO GTPases activate IQGAPs; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; UCH proteinases; Adherens junctions interactions; RHO GTPases activate IQGAPs; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of annular gap junctions" "157" "12" "0.998" "0.993" "1.111" "1.072" "1.054" "1.040" "1.053" "0.983" "0.610" "14241.0" "14206.5" "14135.6" "15826.8" "15260.9" "15012.6" "14810.6" "14989.4" "14002.3" "8693.7" "" "" "" "" "" "" "" "" "" "" "7540.6" "7876.5" "8095.4" "7288.7" "8256.7" "8350.7" "8716.5" "8182.0" "7854.9" "8693.7" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8277375164580502172" "False" "High" "IsMasterProtein" "Q14683" "Structural maintenance of chromosomes protein 1A OS=Homo sapiens OX=9606 GN=SMC1A PE=1 SV=2" "0.000" "False" "135.869" "26" "35" "54" "35" "1233" "143.1" "7.64" "153.53" "35" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "8243" "ENSG00000072501" "SMC1A" "hsa:8243; O14995; Q14683; Q16351; Q2M228" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; Pathways affected in adenoid cystic carcinoma; ATM signaling in development and disease ; mRNA processing; Regulation of sister chromatid separation at the metaphase-anaphase transition; Rett syndrome; CAMKK2 pathway; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; 10q22q23 copy number variation; DNA damage response" "Estrogen-dependent gene expression; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "22" "0" "0.984" "1.007" "0.906" "0.997" "0.990" "0.877" "0.920" "0.957" "0.838" "6943.6" "6831.2" "6995.0" "6292.1" "6923.8" "6873.3" "6087.2" "6387.7" "6645.3" "5820.2" "" "" "" "" "" "" "" "" "" "" "3676.6" "3787.4" "4006.0" "2897.7" "3746.0" "3823.3" "3582.5" "3486.8" "3727.9" "5820.2" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-613397371873318473" "False" "High" "IsMasterProtein" "P34932" "Heat shock 70 kDa protein 4 OS=Homo sapiens OX=9606 GN=HSPA4 PE=1 SV=4" "0.000" "False" "135.398" "36" "31" "48" "31" "840" "94.3" "5.19" "126.38" "31" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport" "non-structural extracellular;cytosol;mitochondrion;nucleus" "other molecular function" "Pf00012" "3308" "ENSG00000170606" "HSPA4" "hsa:3308; O95756; P34932; Q2TAL4; Q9BUK9" "Parkin-ubiquitin proteasomal system pathway; HDAC6 interactions in the central nervous system" "Regulation of HSF1-mediated heat shock response" "3" "0" "0.982" "0.975" "0.992" "0.975" "1.027" "0.958" "0.973" "1.010" "0.974" "3860.9" "3789.9" "3765.5" "3828.6" "3763.6" "3963.7" "3698.6" "3755.8" "3899.8" "3759.3" "" "" "" "" "" "" "" "" "" "" "2044.3" "2101.3" "2156.5" "1763.2" "2036.3" "2204.8" "2176.7" "2050.1" "2187.7" "3759.3" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5561612098835552022" "False" "High" "IsMasterProtein" "P38646" "Stress-70 protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPA9 PE=1 SV=2" "0.000" "False" "132.803" "35" "24" "74" "23" "679" "73.6" "6.16" "218.86" "24" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00012" "3313" "ENSG00000113013" "HSPA9" "B2RCM1; hsa:3313; P30036; P31932; P38646; Q1HB43; Q53H23; Q6GU03; Q9BWB7; Q9UC56" "Parkin-ubiquitin proteasomal system pathway; Iron-sulfur cluster biogenesis" "Mitochondrial protein degradation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Regulation of HSF1-mediated heat shock response; Mitochondrial protein import; Cristae formation" "7" "0" "0.984" "0.977" "1.010" "1.030" "1.054" "0.933" "0.968" "0.937" "0.609" "5530.5" "5439.8" "5403.1" "5588.3" "5696.7" "5828.1" "5161.6" "5353.6" "5182.1" "3366.4" "" "" "" "" "" "" "" "" "" "" "2928.4" "3016.0" "3094.4" "2573.6" "3082.1" "3241.8" "3037.7" "2922.3" "2907.0" "3366.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4243510454319930112" "False" "High" "IsMasterProtein" "P33992" "DNA replication licensing factor MCM5 OS=Homo sapiens OX=9606 GN=MCM5 PE=1 SV=5" "0.000" "False" "131.433" "33" "25" "52" "25" "734" "82.2" "8.37" "145.03" "25" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4174" "ENSG00000100297" "MCM5" "hsa:4174; O60785; P33992; Q14578; Q9BTJ4; Q9BWL8" "Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "10" "0" "0.984" "0.942" "0.965" "1.005" "0.976" "0.884" "0.870" "0.860" "0.708" "5260.3" "5174.7" "4953.2" "5077.5" "5284.5" "5133.5" "4647.9" "4575.4" "4523.9" "3724.7" "" "" "" "" "" "" "" "" "" "" "2785.4" "2869.0" "2836.7" "2338.4" "2859.1" "2855.5" "2735.5" "2497.5" "2537.8" "3724.7" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1518063030880020019" "False" "High" "IsMasterProtein" "P12814" "Alpha-actinin-1 OS=Homo sapiens OX=9606 GN=ACTN1 PE=1 SV=2" "0.000" "False" "128.714" "29" "25" "63" "16" "892" "103.0" "5.41" "166.29" "25" "cell adhesion;cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00307, Pf00435, Pf08726" "87" "ENSG00000072110" "ACTN1" "B3V8S3; B4DHH3; B7TY16; hsa:87; P12814; Q1HE25; Q9BTN1" "Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Ebola virus infection in host; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Regulation of actin cytoskeleton" "RHOD GTPase cycle; RHOF GTPase cycle; Platelet degranulation ; Nephrin family interactions; Syndecan interactions; RHOBTB2 GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "12" "0" "1.001" "1.009" "1.009" "1.013" "1.023" "1.038" "1.035" "0.995" "0.528" "2713.7" "2715.8" "2736.9" "2737.9" "2750.1" "2775.7" "2816.7" "2809.9" "2701.4" "1433.0" "" "" "" "" "" "" "" "" "" "" "1436.9" "1505.7" "1567.4" "1260.9" "1487.9" "1544.0" "1657.7" "1533.8" "1515.4" "1433.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6488855965708197639" "False" "High" "IsMasterProtein" "P14618" "Pyruvate kinase PKM OS=Homo sapiens OX=9606 GN=PKM PE=1 SV=4" "0.000" "False" "127.744" "35" "19" "112" "17" "531" "57.9" "7.84" "297.19" "19" "cell organization and biogenesis;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00224, Pf02887" "5315" "ENSG00000067225" "PKM" "A6NFK3; B2R5N8; B3KRY0; B4DFX8; B4DUU6; hsa:5315; P14618; P14786; Q53GK4; Q96E76; Q9BWB5; Q9UCV6; Q9UPF2" "Photodynamic therapy-induced HIF-1 survival signaling; Amino acid metabolism; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Neutrophil degranulation" "10" "2" "0.980" "0.955" "1.010" "0.994" "0.979" "0.990" "0.971" "0.958" "0.527" "7231.1" "7089.9" "6908.3" "7303.2" "7189.5" "7079.4" "7161.7" "7020.2" "6928.8" "3811.2" "" "" "" "" "" "" "" "" "" "" "3828.9" "3930.8" "3956.4" "3363.4" "3889.8" "3937.9" "4214.9" "3832.0" "3886.9" "3811.2" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6896953880380314494" "False" "High" "IsMasterProtein" "P55072" "Transitional endoplasmic reticulum ATPase OS=Homo sapiens OX=9606 GN=VCP PE=1 SV=4" "0.000" "False" "126.727" "33" "25" "55" "25" "806" "89.3" "5.26" "137.84" "25" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00004, Pf02359, Pf02933, Pf17862" "7415" "ENSG00000165280" "VCP" "B2R5T8; P55072; Q0V924; Q2TAI5; Q969G7; Q9UCD5; V9HW80" "Alstrom syndrome; Clock-controlled autophagy in bone metabolism; HDAC6 interactions in the central nervous system" "Aggrephagy; Neutrophil degranulation; HSF1 activation; ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis; Neddylation; KEAP1-NFE2L2 pathway; RHOH GTPase cycle; E3 ubiquitin ligases ubiquitinate target proteins; Attachment and Entry; Attachment and Entry; Ovarian tumor domain proteases; Josephin domain DUBs; Protein methylation; Translesion Synthesis by POLH; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "21" "0" "1.026" "1.036" "1.016" "1.023" "1.042" "0.995" "1.013" "1.006" "0.558" "3654.8" "3749.8" "3787.9" "3711.9" "3739.1" "3809.0" "3634.9" "3700.9" "3675.0" "2040.7" "" "" "" "" "" "" "" "" "" "" "1935.2" "2079.0" "2169.3" "1709.4" "2023.0" "2118.7" "2139.3" "2020.1" "2061.6" "2040.7" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6996937188134376608" "False" "High" "IsMasterProtein" "Q16531" "DNA damage-binding protein 1 OS=Homo sapiens OX=9606 GN=DDB1 PE=1 SV=1" "0.000" "False" "126.628" "24" "27" "58" "27" "1140" "126.9" "5.26" "159.57" "27" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03178, Pf10433" "1642" "ENSG00000167986" "DDB1" "A6NG77; B2R648; B4DG00; hsa:1642; O15176; Q13289; Q16531; Q58F96" "Hippo-Merlin signaling dysregulation; Hepatitis B infection; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Neddylation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; DNA Damage Recognition in GG-NER; Dual Incision in GG-NER" "14" "0" "0.977" "0.964" "1.008" "1.054" "1.005" "1.045" "1.016" "1.038" "0.614" "3591.6" "3510.5" "3461.9" "3621.8" "3786.0" "3609.5" "3752.2" "3650.2" "3729.5" "2205.2" "" "" "" "" "" "" "" "" "" "" "1901.7" "1946.3" "1982.6" "1667.9" "2048.4" "2007.8" "2208.3" "1992.5" "2092.1" "2205.2" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1511702505276588775" "False" "High" "IsMasterProtein" "Q12931" "Heat shock protein 75 kDa, mitochondrial OS=Homo sapiens OX=9606 GN=TRAP1 PE=1 SV=3" "0.000" "False" "122.589" "30" "18" "62" "17" "704" "80.1" "8.21" "205.50" "18" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00183" "10131" "ENSG00000126602" "TRAP1" "B4DR68; D3DUC8; F5H897; hsa:10131; O43642; O75235; Q12931; Q9UHL5" "TNF-alpha signaling pathway; TGF-beta signaling pathway; Clock-controlled autophagy in bone metabolism" "Respiratory electron transport" "4" "0" "0.998" "1.009" "0.992" "1.059" "1.027" "0.887" "0.932" "0.915" "0.646" "3572.2" "3566.1" "3604.1" "3542.8" "3781.7" "3667.9" "3169.5" "3330.2" "3267.7" "2306.2" "" "" "" "" "" "" "" "" "" "" "1891.5" "1977.1" "2064.1" "1631.6" "2046.1" "2040.3" "1865.3" "1817.8" "1833.1" "2306.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8215909947984891721" "False" "High" "IsMasterProtein" "P27816" "Microtubule-associated protein 4 OS=Homo sapiens OX=9606 GN=MAP4 PE=1 SV=3" "0.000" "False" "121.582" "26" "27" "47" "27" "1152" "120.9" "5.43" "119.55" "27" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00418" "4134" "ENSG00000047849" "MAP4" "P27816; Q13082; Q59FT2; Q68D74; Q6ZUW9; Q86V26; Q96A76; Q96NS9" "Splicing factor NOVA regulated synaptic proteins; 2q37 copy number variation syndrome" "" "2" "0" "0.987" "1.033" "0.940" "0.982" "0.975" "0.921" "1.040" "0.977" "0.537" "5094.3" "5026.9" "5263.2" "4790.4" "5002.6" "4964.5" "4692.6" "5297.4" "4979.5" "2736.5" "" "" "" "" "" "" "" "" "" "" "2697.4" "2787.1" "3014.2" "2206.2" "2706.6" "2761.5" "2761.7" "2891.6" "2793.4" "2736.5" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7379954125319751521" "False" "High" "IsMasterProtein" "P48643" "T-complex protein 1 subunit epsilon OS=Homo sapiens OX=9606 GN=CCT5 PE=1 SV=1" "0.000" "False" "119.574" "40" "23" "58" "22" "541" "59.6" "5.66" "157.24" "23" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00118" "22948" "ENSG00000150753" "CCT5" "A8JZY8; A8K2X8; B4DYD8; hsa:22948; P48643" "16p11.2 proximal deletion syndrome" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "7" "1" "1.026" "1.017" "1.006" "1.037" "1.024" "0.976" "1.028" "0.972" "0.599" "4184.1" "4292.6" "4254.7" "4208.3" "4339.4" "4284.9" "4081.9" "4301.3" "4067.3" "2506.7" "" "" "" "" "" "" "" "" "" "" "2215.5" "2380.0" "2436.6" "1938.1" "2347.8" "2383.5" "2402.3" "2347.9" "2281.6" "2506.7" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8282495750123490209" "False" "High" "IsMasterProtein" "Q96AE4" "Far upstream element-binding protein 1 OS=Homo sapiens OX=9606 GN=FUBP1 PE=1 SV=3" "0.000" "False" "119.429" "36" "21" "57" "17" "644" "67.5" "7.61" "167.75" "21" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00013, Pf09005" "8880" "ENSG00000162613" "FUBP1" "hsa:8880; Q12828; Q96AE4" "" "" "0" "0" "0.965" "1.039" "0.885" "0.951" "0.904" "0.925" "1.042" "1.007" "0.472" "6548.9" "6316.6" "6801.3" "5794.3" "6225.8" "5921.0" "6057.4" "6821.3" "6595.1" "3092.0" "" "" "" "" "" "" "" "" "" "" "3467.6" "3502.1" "3895.1" "2668.4" "3368.4" "3293.5" "3565.0" "3723.5" "3699.7" "3092.0" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1011353078992681906" "False" "High" "IsMasterProtein" "P49736" "DNA replication licensing factor MCM2 OS=Homo sapiens OX=9606 GN=MCM2 PE=1 SV=4" "0.000" "False" "117.938" "26" "22" "41" "22" "904" "101.8" "5.52" "118.93" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf12619, Pf14551, Pf17207, Pf17855" "4171" "ENSG00000073111" "MCM2" "hsa:4171; P49736; Q14577; Q15023; Q8N2V1; Q969W7; Q96AE1; Q9BRM7" "Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication; 1p36 copy number variation syndrome" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "11" "0" "1.020" "0.962" "0.963" "1.013" "0.981" "0.819" "0.795" "0.808" "0.879" "4730.5" "4826.9" "4550.8" "4556.9" "4790.9" "4638.6" "3872.2" "3761.5" "3822.4" "4156.5" "" "" "" "" "" "" "" "" "" "" "2504.8" "2676.1" "2606.3" "2098.6" "2592.0" "2580.2" "2278.9" "2053.2" "2144.3" "4156.5" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2619416957405686977" "False" "High" "IsMasterProtein" "P49321" "Nuclear autoantigenic sperm protein OS=Homo sapiens OX=9606 GN=NASP PE=1 SV=2" "0.000" "False" "116.413" "31" "23" "53" "23" "788" "85.2" "4.30" "144.80" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10516" "4678" "ENSG00000132780" "NASP" "A8K6H2; B4DQP3; D3DQ07; F5H3J2; hsa:4678; P49321; Q53GW5; Q5T622; Q5T625; Q96A69; Q9BTW2" "" "" "0" "0" "0.983" "1.011" "0.963" "0.967" "0.908" "1.022" "1.051" "1.062" "1.077" "4715.2" "4633.9" "4766.8" "4541.0" "4561.1" "4283.3" "4819.0" "4954.3" "5005.4" "5080.6" "" "" "" "" "" "" "" "" "" "" "2496.7" "2569.2" "2730.0" "2091.3" "2467.8" "2382.6" "2836.1" "2704.3" "2807.9" "5080.6" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6880355764133463335" "False" "High" "IsMasterProtein" "P26358" "DNA (cytosine-5)-methyltransferase 1 OS=Homo sapiens OX=9606 GN=DNMT1 PE=1 SV=2" "0.000" "False" "115.565" "18" "29" "48" "29" "1616" "183.1" "7.75" "124.11" "29" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00145, Pf01426, Pf02008, Pf06464, Pf12047" "1786" "ENSG00000130816" "DNMT1" "A0AV63; B7ZLW6; hsa:1786; P26358; Q9UHG5; Q9ULA2; Q9UMZ6" "Trans-sulfuration pathway; One-carbon metabolism; Retinoblastoma gene in cancer; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; MTHFR deficiency; Spina bifida" "SUMOylation of DNA methylation proteins; NoRC negatively regulates rRNA expression; STAT3 nuclear events downstream of ALK signaling; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; Nuclear events stimulated by ALK signaling in cancer" "13" "0" "0.995" "1.031" "0.923" "1.032" "1.035" "0.893" "0.926" "0.983" "0.684" "4813.4" "4786.9" "4960.5" "4443.9" "4965.6" "4981.9" "4298.0" "4457.6" "4730.1" "3291.1" "" "" "" "" "" "" "" "" "" "" "2548.7" "2654.0" "2840.9" "2046.6" "2686.6" "2771.2" "2529.5" "2433.2" "2653.5" "3291.1" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7224600777690592247" "False" "High" "IsMasterProtein" "P50991" "T-complex protein 1 subunit delta OS=Homo sapiens OX=9606 GN=CCT4 PE=1 SV=4" "0.000" "False" "113.733" "37" "21" "64" "20" "539" "57.9" "7.83" "178.33" "21" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00118" "10575" "ENSG00000115484" "CCT4" "B2R6I3; B7Z8B1; F5H5W3; hsa:10575; O14870; P50991; Q53QP9; Q96C51" "16p11.2 proximal deletion syndrome" "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "7" "0" "1.014" "1.003" "0.998" "1.033" "1.018" "1.007" "1.032" "0.983" "0.595" "4857.8" "4928.0" "4872.5" "4847.7" "5019.4" "4944.0" "4889.8" "5015.2" "4775.6" "2892.3" "" "" "" "" "" "" "" "" "" "" "2572.2" "2732.2" "2790.5" "2232.5" "2715.7" "2750.1" "2877.8" "2737.6" "2679.0" "2892.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5864065326781896084" "False" "High" "IsMasterProtein" "P27708" "Multifunctional protein CAD OS=Homo sapiens OX=9606 GN=CAD PE=1 SV=3" "0.000" "False" "112.745" "13" "29" "46" "29" "2225" "242.8" "6.46" "133.37" "29" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00117, Pf00185, Pf00988, Pf01979, Pf02142, Pf02729, Pf02786, Pf02787" "790" "ENSG00000084774" "CAD" "D6W552; hsa:790; P27708; Q6P0Q0; Q96CK3" "Endothelin pathways; Amino acid metabolism; Pyrimidine metabolism" "Pyrimidine biosynthesis" "4" "0" "1.013" "0.964" "1.034" "1.045" "1.078" "0.940" "0.923" "0.929" "1.087" "3427.1" "3470.8" "3303.5" "3545.0" "3582.3" "3694.7" "3220.2" "3162.0" "3185.3" "3724.7" "" "" "" "" "" "" "" "" "" "" "1814.6" "1924.3" "1891.9" "1632.6" "1938.2" "2055.2" "1895.2" "1726.0" "1786.9" "3724.7" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1047119725647514999" "False" "High" "IsMasterProtein" "P23588" "Eukaryotic translation initiation factor 4B OS=Homo sapiens OX=9606 GN=EIF4B PE=1 SV=2" "0.000" "False" "112.037" "28" "19" "59" "19" "611" "69.1" "5.73" "180.63" "19" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "nucleic acid binding activity" "Pf00076" "1975" "ENSG00000063046" "EIF4B" "B4DS13; hsa:1975; P23588; Q4G0E3; Q53HQ2; Q6GPH5; Q6IB46; Q8WYK5" "Translation factors; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Pleural mesothelioma; Interferon type I signaling pathways" "Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; mTORC1-mediated signalling; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "16" "0" "0.966" "1.036" "1.040" "0.974" "0.908" "0.922" "0.905" "0.835" "0.453" "5445.8" "5259.1" "5643.7" "5665.2" "5303.7" "4945.7" "5022.1" "4930.4" "4549.9" "2466.9" "" "" "" "" "" "" "" "" "" "" "2883.6" "2915.8" "3232.1" "2609.0" "2869.5" "2751.0" "2955.7" "2691.3" "2552.4" "2466.9" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3851021478040607723" "False" "High" "IsMasterProtein" "P31939" "Bifunctional purine biosynthesis protein ATIC OS=Homo sapiens OX=9606 GN=ATIC PE=1 SV=3" "0.000" "False" "111.532" "42" "21" "41" "21" "592" "64.6" "6.71" "116.16" "21" "other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol" "other molecular function" "Pf01808, Pf02142" "471" "ENSG00000138363" "ATIC" "A8K202; E9PBU3; hsa:471; P31939; Q13856; Q53S28" "One-carbon metabolism" "Signaling by ALK fusions and activated point mutants; Purine ribonucleoside monophosphate biosynthesis" "3" "0" "0.957" "0.970" "1.008" "0.918" "0.968" "0.835" "0.866" "0.821" "0.591" "4116.5" "3939.0" "3991.8" "4149.6" "3780.4" "3986.5" "3439.2" "3566.3" "3378.0" "2433.5" "" "" "" "" "" "" "" "" "" "" "2179.7" "2183.9" "2286.1" "1911.0" "2045.3" "2217.5" "2024.1" "1946.7" "1894.9" "2433.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1213395878895108528" "False" "High" "IsMasterProtein" "P26038" "Moesin OS=Homo sapiens OX=9606 GN=MSN PE=1 SV=3" "0.000" "False" "111.152" "34" "26" "56" "22" "577" "67.8" "6.40" "160.88" "26" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "4478" "ENSG00000147065" "MSN" "hsa:4478; P26038" "Glial cell differentiation; AGE/RAGE pathway; Measles virus infection; 16p11.2 proximal deletion syndrome; Regulation of actin cytoskeleton" "Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Signaling by ALK fusions and activated point mutants" "10" "3" "0.946" "1.026" "0.930" "0.948" "0.884" "0.908" "1.057" "0.983" "0.652" "5876.6" "5556.8" "6027.3" "5468.1" "5568.9" "5194.8" "5333.2" "6212.5" "5777.2" "3832.8" "" "" "" "" "" "" "" "" "" "" "3111.7" "3080.8" "3451.8" "2518.2" "3013.0" "2889.6" "3138.8" "3391.1" "3240.9" "3832.8" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9169618704545618170" "False" "High" "IsMasterProtein" "P04075" "Fructose-bisphosphate aldolase A OS=Homo sapiens OX=9606 GN=ALDOA PE=1 SV=2" "0.000" "False" "111.136" "45" "19" "109" "15" "364" "39.4" "8.09" "309.54" "19" "cell organization and biogenesis;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00274" "226" "ENSG00000149925" "ALDOA" "B4DXI7; hsa:226; P04075; Q6FH76; Q6FI10; Q96B15; Q9BWD9; Q9UCN2" "VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; 16p11.2 proximal deletion syndrome; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; Sudden infant death syndrome (SIDS) susceptibility pathways" "Neutrophil degranulation; Glycolysis; Gluconeogenesis; Platelet degranulation" "11" "2" "0.942" "1.020" "0.996" "0.914" "0.950" "0.898" "0.978" "0.861" "0.534" "7957.8" "7492.5" "8113.9" "7925.1" "7276.6" "7561.1" "7148.6" "7779.3" "6853.7" "4251.6" "" "" "" "" "" "" "" "" "" "" "4213.7" "4154.0" "4646.8" "3649.8" "3936.9" "4205.8" "4207.2" "4246.4" "3844.8" "4251.6" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8012908085941337264" "False" "High" "IsMasterProtein" "Q99832" "T-complex protein 1 subunit eta OS=Homo sapiens OX=9606 GN=CCT7 PE=1 SV=2" "0.000" "False" "110.272" "34" "19" "59" "19" "543" "59.3" "7.65" "171.62" "19" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00118" "10574" "ENSG00000135624" "CCT7" "A8K7E6; A8MWI8; B7WNW9; B7Z4T9; B7Z4Z7; hsa:10574; O14871; Q6FI26; Q99832" "VEGFA-VEGFR2 signaling; 16p11.2 proximal deletion syndrome" "RHOBTB1 GTPase cycle; Formation of tubulin folding intermediates by CCT/TriC; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC" "9" "0" "0.982" "0.991" "1.010" "1.023" "0.950" "0.965" "0.994" "0.935" "0.563" "4811.3" "4725.7" "4770.1" "4857.5" "4923.9" "4570.7" "4641.6" "4780.7" "4496.8" "2708.5" "" "" "" "" "" "" "" "" "" "" "2547.6" "2620.0" "2731.8" "2237.0" "2664.0" "2542.5" "2731.8" "2609.6" "2522.6" "2708.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1119286615561917853" "False" "High" "IsMasterProtein" "P00558" "Phosphoglycerate kinase 1 OS=Homo sapiens OX=9606 GN=PGK1 PE=1 SV=3" "0.000" "False" "109.979" "47" "18" "92" "14" "417" "44.6" "8.10" "226.61" "18" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;cytosol" "kinase activity;other molecular function" "Pf00162" "5230" "ENSG00000102144" "PGK1" "A8K4W6; B7Z7A9; hsa:5230; P00558; Q5J7W1; Q6IBT6; Q8NI87" "Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Warburg effect modulated by deubiquitinating enzymes and their substrates; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Gluconeogenesis; Manipulation of host energy metabolism" "13" "4" "0.966" "0.979" "0.968" "0.959" "1.004" "0.938" "0.968" "0.880" "0.537" "7817.8" "7552.5" "7656.4" "7564.5" "7494.4" "7852.9" "7333.1" "7564.0" "6876.0" "4201.5" "" "" "" "" "" "" "" "" "" "" "4139.5" "4187.3" "4384.8" "3483.7" "4054.7" "4368.1" "4315.8" "4128.9" "3857.3" "4201.5" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-516006275001987462" "False" "High" "IsMasterProtein" "Q14566" "DNA replication licensing factor MCM6 OS=Homo sapiens OX=9606 GN=MCM6 PE=1 SV=1" "0.000" "False" "109.378" "27" "24" "44" "24" "821" "92.8" "5.41" "130.20" "24" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855, Pf18263" "4175" "ENSG00000076003" "MCM6" "B2R6H2; hsa:4175; Q13504; Q14566; Q99859" "Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "11" "0" "0.997" "1.015" "1.004" "1.034" "1.038" "0.874" "0.831" "0.807" "0.917" "3299.1" "3290.2" "3347.4" "3313.1" "3410.9" "3424.2" "2884.3" "2742.7" "2661.7" "3026.6" "" "" "" "" "" "" "" "" "" "" "1746.9" "1824.2" "1917.0" "1525.8" "1845.4" "1904.7" "1697.5" "1497.1" "1493.1" "3026.6" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8649453304125061400" "False" "High" "IsMasterProtein" "Q12906" "Interleukin enhancer-binding factor 3 OS=Homo sapiens OX=9606 GN=ILF3 PE=1 SV=3" "0.000" "False" "107.824" "28" "21" "51" "17" "894" "95.3" "8.76" "128.47" "21" "protein metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf07528, Pf20965" "3609" "ENSG00000129351" "ILF3" "A8K6F2; G5E9M5; hsa:3609; O43409; Q12906; Q6P1X1; Q86XY7; Q99544; Q99545; Q9BZH4; Q9BZH5; Q9NQ95; Q9NQ96; Q9NQ97; Q9NQ98; Q9NQ99; Q9NQA0; Q9NQA1; Q9NQA2; Q9NRN2; Q9NRN3; Q9NRN4; Q9UMZ9; Q9UN00; Q9UN84; Q9UNA2" "" "PKR-mediated signaling; Regulation of CDH11 gene transcription" "2" "2" "1.003" "1.005" "1.031" "1.022" "1.003" "1.072" "1.055" "1.098" "0.649" "3045.0" "3053.1" "3059.1" "3140.7" "3111.5" "3053.4" "3265.8" "3211.0" "3343.2" "1977.5" "" "" "" "" "" "" "" "" "" "" "1612.3" "1692.7" "1752.0" "1446.4" "1683.4" "1698.5" "1922.0" "1752.7" "1875.4" "1977.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3490068427957957642" "False" "High" "IsMasterProtein" "P49588" "Alanine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=AARS1 PE=1 SV=2" "0.000" "False" "106.790" "21" "21" "50" "21" "968" "106.7" "5.53" "143.99" "21" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf01411, Pf02272, Pf07973" "16" "ENSG00000090861" "AARS1" "A6NF14; B4DR45; hsa:16; P49588; Q53GV7; Q96FA0" "IL-18 signaling pathway" "Cytosolic tRNA aminoacylation" "2" "0" "0.951" "0.994" "0.940" "0.953" "0.972" "0.802" "0.817" "0.841" "0.625" "5135.3" "4883.6" "5106.4" "4825.3" "4893.6" "4993.1" "4119.9" "4195.9" "4320.7" "3208.9" "" "" "" "" "" "" "" "" "" "" "2719.2" "2707.6" "2924.4" "2222.2" "2647.6" "2777.4" "2424.7" "2290.3" "2423.8" "3208.9" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3959572878681588940" "False" "High" "IsMasterProtein" "P17987" "T-complex protein 1 subunit alpha OS=Homo sapiens OX=9606 GN=TCP1 PE=1 SV=1" "0.000" "False" "104.914" "35" "19" "42" "19" "556" "60.3" "6.11" "119.26" "19" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00118" "6950" "ENSG00000120438" "TCP1" "E1P5B2; hsa:6950; P17987; Q15556; Q5TCM3" "16p11.2 proximal deletion syndrome" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "8" "0" "0.982" "1.012" "1.006" "0.994" "1.015" "0.981" "1.024" "0.935" "0.624" "3390.2" "3328.4" "3430.6" "3410.4" "3370.9" "3442.8" "3326.3" "3471.4" "3171.3" "2114.0" "" "" "" "" "" "" "" "" "" "" "1795.1" "1845.3" "1964.7" "1570.6" "1823.8" "1915.0" "1957.6" "1894.9" "1779.0" "2114.0" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8533826193911874289" "False" "High" "IsMasterProtein" "Q86VP6" "Cullin-associated NEDD8-dissociated protein 1 OS=Homo sapiens OX=9606 GN=CAND1 PE=1 SV=2" "0.000" "False" "104.737" "20" "26" "43" "26" "1230" "136.3" "5.78" "103.60" "26" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf08623, Pf13513" "55832" "ENSG00000111530" "CAND1" "B2RAU3; hsa:55832; O94918; Q6PIY4; Q86VP6; Q8NDJ4; Q96JZ9; Q96T19; Q9BTC4; Q9H0G2; Q9P0H7; Q9UF85" "Endoderm differentiation" "Neutrophil degranulation; Neddylation; Iron uptake and transport" "4" "0" "1.021" "1.000" "0.973" "1.011" "1.026" "0.980" "1.064" "0.994" "0.570" "3940.3" "4021.9" "3940.5" "3835.3" "3983.8" "4041.2" "3862.9" "4193.7" "3915.7" "2245.0" "" "" "" "" "" "" "" "" "" "" "2086.4" "2229.9" "2256.7" "1766.3" "2155.4" "2247.9" "2273.4" "2289.1" "2196.6" "2245.0" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5579729439990208910" "False" "High" "IsMasterProtein" "P06733" "Alpha-enolase OS=Homo sapiens OX=9606 GN=ENO1 PE=1 SV=2" "0.000" "False" "104.322" "40" "16" "97" "16" "434" "47.1" "7.39" "240.89" "16" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00113, Pf03952" "2023" "ENSG00000074800" "ENO1" "B2RD59; hsa:2023; P06733; P22712; Q16704; Q4TUS4; Q53FT9; Q53HR3; Q658M5; Q6GMP2; Q71V37; Q7Z3V6; Q8WU71; Q96GV1; Q9BT62; Q9UCH6; Q9UM55" "Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; IL-18 signaling pathway; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Gluconeogenesis; Manipulation of host energy metabolism" "9" "0" "0.947" "1.032" "0.930" "0.948" "0.944" "0.999" "0.957" "0.892" "0.549" "6419.6" "6078.8" "6623.5" "5970.2" "6088.9" "6063.0" "6411.9" "6141.9" "5726.1" "3526.2" "" "" "" "" "" "" "" "" "" "" "3399.2" "3370.3" "3793.3" "2749.5" "3294.3" "3372.5" "3773.6" "3352.6" "3212.2" "3526.2" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6942352143814958774" "False" "High" "IsMasterProtein" "P49368" "T-complex protein 1 subunit gamma OS=Homo sapiens OX=9606 GN=CCT3 PE=1 SV=4" "0.000" "False" "104.224" "37" "20" "70" "20" "545" "60.5" "6.49" "177.24" "20" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00118" "7203" "ENSG00000163468" "CCT3" "A6NE14; hsa:7203; P49368; Q5SZY1; Q9BR64" "16p11.2 proximal deletion syndrome" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "7" "0" "0.995" "0.971" "1.009" "1.022" "1.001" "1.023" "1.000" "1.020" "0.663" "4818.6" "4794.9" "4678.9" "4860.6" "4924.8" "4823.9" "4931.4" "4820.1" "4916.1" "3194.1" "" "" "" "" "" "" "" "" "" "" "2551.5" "2658.4" "2679.6" "2238.5" "2664.5" "2683.3" "2902.3" "2631.1" "2757.8" "3194.1" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3038689840563559267" "False" "High" "IsMasterProtein" "Q8WWM7" "Ataxin-2-like protein OS=Homo sapiens OX=9606 GN=ATXN2L PE=1 SV=2" "0.000" "False" "104.182" "25" "23" "31" "22" "1075" "113.3" "8.59" "105.37" "23" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf06741, Pf07145, Pf14438" "11273" "ENSG00000168488" "ATXN2L" "A8K1R6; B9EGM2; E9PAR9; hsa:11273; O95135; Q63ZY4; Q6NVJ8; Q6PJW6; Q8IU61; Q8IU95; Q8WWM3; Q8WWM4; Q8WWM5; Q8WWM6; Q8WWM7; Q99703" "16p11.2 distal deletion syndrome" "" "1" "0" "1.002" "1.088" "1.001" "1.027" "1.027" "1.029" "1.140" "1.088" "0.810" "2771.8" "2778.2" "3015.7" "2774.2" "2845.9" "2846.5" "2853.2" "3158.6" "3014.8" "2244.8" "" "" "" "" "" "" "" "" "" "" "1467.6" "1540.3" "1727.1" "1277.6" "1539.8" "1583.4" "1679.2" "1724.2" "1691.2" "2244.8" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "528371413836643526" "False" "High" "IsMasterProtein" "Q92945" "Far upstream element-binding protein 2 OS=Homo sapiens OX=9606 GN=KHSRP PE=1 SV=4" "0.000" "False" "104.111" "36" "22" "46" "19" "711" "73.1" "7.30" "125.13" "22" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf09005" "8570" "ENSG00000088247" "KHSRP" "hsa:8570; O00301; Q59EZ9; Q5U4P6; Q92945; Q9UNT5; Q9UQH5" "Pre-implantation embryo" "ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA" "3" "3" "1.005" "1.072" "0.957" "1.044" "0.988" "0.943" "1.079" "1.051" "0.670" "3738.6" "3755.6" "4008.8" "3576.0" "3903.1" "3695.5" "3524.2" "4032.1" "3929.5" "2503.9" "" "" "" "" "" "" "" "" "" "" "1979.6" "2082.2" "2295.8" "1646.9" "2111.7" "2055.6" "2074.1" "2201.0" "2204.3" "2503.9" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-291186294764485320" "False" "High" "IsMasterProtein" "P33993" "DNA replication licensing factor MCM7 OS=Homo sapiens OX=9606 GN=MCM7 PE=1 SV=4" "0.000" "False" "103.883" "34" "23" "37" "23" "719" "81.3" "6.46" "105.61" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4176" "ENSG00000166508" "MCM7" "A4D2A1; A4D2A2; E9PGN9; hsa:4176; P33993; Q15076; Q96D34; Q96GL1" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "12" "0" "0.982" "0.968" "0.906" "0.973" "0.998" "0.833" "0.784" "0.809" "0.890" "4150.5" "4076.5" "4015.8" "3760.8" "4040.0" "4142.9" "3459.1" "3255.0" "3357.6" "3695.1" "" "" "" "" "" "" "" "" "" "" "2197.7" "2260.1" "2299.8" "1732.0" "2185.8" "2304.5" "2035.8" "1776.7" "1883.5" "3695.1" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8705476780399299386" "False" "High" "IsMasterProtein" "P46940" "Ras GTPase-activating-like protein IQGAP1 OS=Homo sapiens OX=9606 GN=IQGAP1 PE=1 SV=1" "0.000" "False" "102.736" "15" "23" "34" "23" "1657" "189.1" "6.48" "97.83" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00307, Pf00612, Pf00616, Pf03836" "8826" "ENSG00000140575" "IQGAP1" "A7MBM3; hsa:8826; P46940" "VEGFA-VEGFR2 signaling; Ebola virus infection in host; Ciliary landscape; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "Signaling by BRAF and RAF1 fusions; Neutrophil degranulation; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases activate IQGAPs; RAC2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "25" "0" "1.013" "0.991" "0.952" "0.952" "0.992" "0.899" "0.712" "0.953" "2.728" "1686.2" "1707.9" "1671.4" "1604.8" "1604.9" "1672.5" "1515.8" "1200.2" "1606.7" "4599.7" "" "" "" "" "" "" "" "" "" "" "892.8" "946.9" "957.2" "739.1" "868.3" "930.3" "892.1" "655.1" "901.3" "4599.7" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-256091368978195991" "False" "High" "IsMasterProtein" "Q32MZ4" "Leucine-rich repeat flightless-interacting protein 1 OS=Homo sapiens OX=9606 GN=LRRFIP1 PE=1 SV=2" "0.000" "False" "101.632" "28" "21" "39" "20" "808" "89.2" "4.65" "111.01" "21" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09738" "9208" "ENSG00000124831" "LRRFIP1" "E9PGZ2; hsa:9208; O75766; O75799; Q32MZ4; Q32MZ5; Q53T49; Q6PKG2; Q9Y607" "IL-18 signaling pathway; 2q37 copy number variation syndrome" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production" "5" "1" "0.937" "1.022" "1.007" "0.964" "0.936" "1.008" "1.072" "1.005" "0.645" "3786.7" "3549.2" "3871.9" "3814.2" "3649.9" "3544.4" "3815.9" "4061.2" "3804.8" "2444.0" "" "" "" "" "" "" "" "" "" "" "2005.0" "1967.8" "2217.4" "1756.6" "1974.7" "1971.6" "2245.8" "2216.8" "2134.4" "2444.0" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3002712347046388220" "False" "High" "IsMasterProtein" "P78371" "T-complex protein 1 subunit beta OS=Homo sapiens OX=9606 GN=CCT2 PE=1 SV=4" "0.000" "False" "101.288" "37" "18" "56" "18" "535" "57.5" "6.46" "160.33" "18" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00118" "10576" "ENSG00000166226" "CCT2" "A8K402; B5BTY7; B7Z243; B7Z7K4; B7ZAT2; hsa:10576; P78371; Q14D36; Q6IAT3" "16p11.2 proximal deletion syndrome" "Neutrophil degranulation; Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle; Folding of actin by CCT/TriC" "10" "0" "0.981" "0.972" "0.978" "1.008" "1.001" "0.975" "1.001" "0.971" "0.559" "4924.3" "4829.4" "4785.0" "4817.3" "4962.1" "4929.6" "4800.0" "4927.8" "4779.4" "2752.2" "" "" "" "" "" "" "" "" "" "" "2607.4" "2677.6" "2740.4" "2218.5" "2684.7" "2742.1" "2825.0" "2689.9" "2681.2" "2752.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7115142250704838097" "False" "High" "IsMasterProtein" "P08670" "Vimentin OS=Homo sapiens OX=9606 GN=VIM PE=1 SV=4" "0.000" "False" "99.632" "44" "22" "66" "21" "466" "53.6" "5.12" "184.27" "22" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00038, Pf04732" "7431" "ENSG00000026025" "VIM" "B0YJC2; D3DRU4; hsa:7431; P08670; Q15867; Q15868; Q15869; Q548L2; Q6LER9; Q8N850; Q96ML2; Q9NTM3" "Allograft rejection; Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Mammary gland development pathway - Puberty (Stage 2 of 4); Apoptosis-related network due to altered Notch3 in ovarian cancer; Striated muscle contraction pathway; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Ciliary landscape; Burn wound healing; CCL18 signaling pathway; TROP2 regulatory signaling; Macrophage-stimulating protein (MSP) signaling network map; HDAC6 interactions in the central nervous system; T-cell receptor signaling pathway" "Late endosomal microautophagy; Aggrephagy; Interleukin-4 and Interleukin-13 signaling; Striated Muscle Contraction; RHOBTB1 GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins; Chaperone Mediated Autophagy" "21" "1" "0.955" "1.018" "0.982" "1.059" "1.050" "1.479" "1.720" "1.654" "0.626" "5693.8" "5435.2" "5795.1" "5590.0" "6027.1" "5976.2" "8422.2" "9793.1" "9419.6" "3565.4" "" "" "" "" "" "" "" "" "" "" "3014.8" "3013.4" "3318.8" "2574.4" "3260.9" "3324.2" "4956.7" "5345.6" "5284.1" "3565.4" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3353104297975983136" "False" "High" "IsMasterProtein" "O43242" "26S proteasome non-ATPase regulatory subunit 3 OS=Homo sapiens OX=9606 GN=PSMD3 PE=1 SV=2" "0.000" "False" "97.500" "36" "19" "48" "19" "534" "60.9" "8.44" "113.88" "19" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01399, Pf08375" "5709" "ENSG00000108344" "PSMD3" "B3KMW9; B4DT72; hsa:5709; O43242; Q96EI2; Q9BQA4" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "1.055" "0.991" "1.021" "1.022" "1.033" "0.897" "0.937" "0.952" "0.739" "4168.7" "4398.8" "4129.4" "4256.2" "4258.4" "4308.0" "3740.6" "3907.4" "3968.2" "3082.4" "" "" "" "" "" "" "" "" "" "" "2207.3" "2438.8" "2364.9" "1960.1" "2304.0" "2396.3" "2201.5" "2132.9" "2226.1" "3082.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3927890985374291245" "False" "High" "IsMasterProtein" "P11586" "C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=MTHFD1 PE=1 SV=4" "0.000" "False" "96.313" "23" "20" "55" "19" "935" "101.5" "7.30" "154.03" "20" "other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf00763, Pf01268, Pf02882" "4522" "ENSG00000100714" "MTHFD1" "A0A024R652; A0A384N5Y3; B2R5Y2; G3V2B8; hsa:4522; P11586; Q86VC9; Q9BVP5" "Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Male infertility; Spina bifida" "Metabolism of folate and pterines" "6" "1" "0.963" "0.935" "0.922" "0.991" "0.968" "0.848" "0.825" "0.845" "0.816" "3080.1" "2966.5" "2880.8" "2839.4" "3053.4" "2981.2" "2613.0" "2540.0" "2603.9" "2514.4" "" "" "" "" "" "" "" "" "" "" "1630.9" "1644.7" "1649.9" "1307.6" "1652.0" "1658.3" "1537.8" "1386.5" "1460.7" "2514.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8288854614025876019" "False" "High" "IsMasterProtein" "P62258" "14-3-3 protein epsilon OS=Homo sapiens OX=9606 GN=YWHAE PE=1 SV=1" "0.000" "False" "96.246" "71" "18" "106" "15" "255" "29.2" "4.74" "255.52" "18" "stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00244" "7531" "ENSG00000108953; ENSG00000274474" "YWHAE" "B3KY71; D3DTH5; hsa:7531; P29360; P42655; P62258; Q4VJB6; Q53XZ5; Q63631; Q7M4R4" "Cell cycle; Myometrial relaxation and contraction pathways; VEGFA-VEGFR2 signaling; Calcium regulation in cardiac cells; 17p13.3 (YWHAE) copy number variation; Sudden infant death syndrome (SIDS) susceptibility pathways" "RAB GEFs exchange GTP for GDP on RABs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria ; Regulation of HSF1-mediated heat shock response; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Signaling by Hippo; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; HSF1 activation; NADE modulates death signalling" "26" "3" "1.027" "1.069" "0.948" "1.000" "0.988" "0.982" "1.061" "1.109" "0.710" "7199.8" "7392.5" "7697.0" "6828.1" "7198.9" "7115.2" "7073.4" "7639.5" "7987.8" "5113.3" "" "" "" "" "" "" "" "" "" "" "3812.3" "4098.6" "4408.0" "3144.6" "3894.9" "3957.8" "4162.9" "4170.1" "4480.9" "5113.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "361994698644895597" "False" "High" "IsMasterProtein" "P07355" "Annexin A2 OS=Homo sapiens OX=9606 GN=ANXA2 PE=1 SV=2" "0.000" "False" "95.984" "41" "16" "40" "16" "339" "38.6" "7.75" "110.64" "16" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00191" "302" "ENSG00000182718" "ANXA2" "hsa:302; P07355; Q567R4; Q6N0B3; Q8TBV2; Q96DD5; Q9UDH8" "Gastrin signaling pathway; CCL18 signaling pathway; Prostaglandin synthesis and regulation" "Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Smooth Muscle Contraction; Dissolution of Fibrin Clot" "7" "0" "0.943" "1.020" "0.917" "0.990" "1.007" "0.878" "1.058" "0.958" "0.605" "4994.0" "4710.2" "5091.7" "4581.9" "4945.9" "5031.4" "4385.7" "5283.9" "4782.8" "3021.7" "" "" "" "" "" "" "" "" "" "" "2644.3" "2611.5" "2916.0" "2110.1" "2675.9" "2798.7" "2581.1" "2884.2" "2683.0" "3021.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6718063858029524947" "False" "High" "IsMasterProtein" "P50395" "Rab GDP dissociation inhibitor beta OS=Homo sapiens OX=9606 GN=GDI2 PE=1 SV=2" "0.000" "False" "94.876" "43" "18" "43" "14" "445" "50.6" "6.47" "99.20" "18" "transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "2665" "ENSG00000057608" "GDI2" "hsa:2665; O43928; P50395; Q5SX88; Q9UQM6" "" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs" "2" "3" "0.934" "0.996" "1.014" "0.955" "0.952" "0.921" "1.005" "0.861" "0.542" "4081.7" "3814.0" "4063.6" "4137.8" "3898.3" "3884.1" "3759.8" "4102.1" "3514.4" "2212.7" "" "" "" "" "" "" "" "" "" "" "2161.3" "2114.6" "2327.2" "1905.6" "2109.1" "2160.5" "2212.8" "2239.2" "1971.5" "2212.7" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6480137070562712140" "False" "High" "IsMasterProtein" "Cont_Q2KJD0" "Tubulin beta-5 chain OS=Bos taurus OX=9913 GN=TUBB5 PE=2 SV=1" "0.000" "True" "94.616" "43" "16" "90" "3" "444" "49.6" "4.89" "185.91" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "100022562; 100172938; 100303606; 100598146; 100689091; 100718713; 100918219; 100998701; 101034943; 101095657; 101129890; 101318992; 101341456; 101365832; 101593768; 101827904; 101925816; 101965993; 102168953; 102382532; 102506772; 102536943; 102568349; 102831964; 102882060; 102926495; 102963307; 103014346; 103053177; 103080542; 103205965; 103221819; 103261319; 103665004; 104666199; 105074100; 105087494; 105308138; 105498618; 105513957; 105553127; 105600022; 105704569; 105817283; 105855398; 105996956; 106553108; 106825507; 106966617; 107160457; 107498082; 108520633; 108522550; 109249509; 109693530; 203068; 22154; 29214; 396254; 471960; 474830; 574113; 615087; 733686" "ENSACCG00020016918; ENSAMEG00000014418; ENSANAG00000034194; ENSANIG00000003763; ENSAOWG00000004252; ENSBGRG00000008599; ENSBIXG00000008022; ENSBIXG00005015569; ENSBMSG00010013877; ENSBTAG00000006969; ENSCABG00000008181; ENSCAFG00000000443; ENSCAFG00040015599; ENSCAFG00845007927; ENSCANG00000012112; ENSCATG00000014335; ENSCCNG00000028823; ENSCGRG00000007995; ENSCGRG00001023930; ENSCGRG00015028239; ENSCHIG00000025610; ENSCJAG00000048479; ENSCMUG00000016892; ENSCPOG00000035463; ENSCRFG00000007002; ENSCSAG00000008279; ENSCWAG00000006690; ENSEASG00005019680; ENSFCAG00000027444; ENSG00000183311; ENSG00000196230; ENSG00000224156; ENSG00000227739; ENSG00000229684; ENSG00000232421; ENSG00000232575; ENSG00000235067; ENSGAGG00000007027; ENSGGOG00000022655; ENSJJAG00000024145; ENSLCNG00005007041; ENSMFAG00000044340; ENSMICG00000010647; ENSMLEG00000037482; ENSMMMG00000020216; ENSMMNG00015000200; ENSMMNG00015000533; ENSMMNG00015004763; ENSMMSG00000005300; ENSMMUG00000030028; ENSMNEG00000044824; ENSMODG00000023805; ENSMSIG00000015128; ENSMUSG00000001525; ENSNLEG00000005348; ENSOANG00000004061; ENSOARG00000011626; ENSPANG00000015954; ENSPCLG00000013695; ENSPCOG00000022809; ENSPCTG00005009625; ENSPEMG00000025556; ENSPLOG00000016488; ENSPPYG00000016419; ENSPSNG00000012487; ENSPTEG00000030284; ENSPTIG00000006316; ENSPTRG00000017675; ENSRBIG00000034281; ENSRFEG00010000368; ENSRNOG00000061216; ENSRNOG00055006845; ENSRNOG00060003580; ENSRNOG00065029671; ENSRROG00000035442; ENSSBOG00000020987; ENSSDAG00000016166; ENSSHAG00000028751; ENSSHBG00005000940; ENSSOCG00000016453; ENSSSCG00000001379; ENSSSCG00015022877; ENSSSCG00025077784; ENSSSCG00030060370; ENSSSCG00035060189; ENSSSCG00040067819; ENSSSCG00050020383; ENSSSCG00055030461; ENSSSCG00060047808; ENSSSCG00065051381; ENSSSCG00070024618; ENSSSUG00005002289; ENSSTOG00000023492; ENSSVLG00005006345; ENSTGEG00000009306; ENSTGEG00000012139; ENSTGUG00000029087; ENSTSYG00000035292; ENSUAMG00000026276; ENSUMAG00000019678; ENSUPAG00010003937; ENSVURG00010001582; ENSVVUG00000009892; ENSZLMG00000006871" "LOC101341456; LOC106553108; LOC111152509; LOC112622444; LOC114901775; LOC115493080; LOC116436919; TBB7; Tubb; TUBB; Tubb5; TUBB5" "A0A0B8RPP1; A0A0D9R7E7; A0A151MZH9; A0A1S3GEI3; A0A1U7R7I2; A0A1U7SI21; A0A1U7TVN8; A0A1V4L0F2; A0A1W7RC49; A0A218U794; A0A286XDY8; A0A2D4LT52; A0A2D4PSK3; A0A2I3MS98; A0A2J8NXA1; A0A2J8SJF9; A0A2K5EIS8; A0A2K5HGL3; A0A2K5KT86; A0A2K5WBU4; A0A2K5ZFW6; A0A2K6E8N3; A0A2K6G5S3; A0A2K6LAT7; A0A2K6Q336; A0A2K6SLG3; A0A2U3V2D1; A0A2U3WJT7; A0A2Y9EAZ4; A0A2Y9EP82; A0A2Y9HLQ0; A0A2Y9K0M9; A0A2Y9MS78; A0A340WI11; A0A341AY80; A0A384BFD0; A0A384C9R0; A0A387L8L1; A0A3Q7RLV2; A0A3Q7S184; A0A452G3S8; A0A452H2Z1; A0A452SPC5; A0A480TK33; A0A485NK51; A0A4D9DG40; A0A4W2C297; A0A4X2JR93; A0A5E4AVV9; A0A5N3VZ42; A0A5N3WG73; A0A5N4CSN6; A0A663FK44; A0A667GBL5; A0A669QEL9; A0A671DQJ6; A0A672TGM1; A0A673T1T3; A0A674HV74; A0A6B2F8Z8; A0A6B2F9Q6; A0A6I9ILN3; A0A6I9MI92; A0A6I9YS87; A0A6I9ZH14; A0A6J0V952; A0A6J0X5U3; A0A6J1VI28; A0A6J2LA47; A0A6J3H9X1; A0A6P3EF00; A0A6P3RZ49; A0A6P5RBI7; A0A6P6HAZ1; A0A6P7XJA2; A0A6P8P8N4; A0A6P9CC67; A0A6P9FE20; A0A7J7R527; A0A7J7RLA9; A0A7J8GU45; A0A7J8KJ46; A0A7N4PPV2; A0A811YN81; A0A8B7ATI1; A0A8B7EBT6; A0A8B7VFP4; A0A8B9M868; A0A8B9P6J0; A0A8B9X0N8; A0A8C0I1Y2; A0A8C0IPC0; A0A8C0SSP9; A0A8C3VZK5; A0A8C3XAR0; A0A8C4PT60; A0A8C5LKQ9; A0A8C6AUQ3; A0A8C6EXU6; A0A8C6FHM7; A0A8C6MWA3; A0A8C8XQA1; A0A8C9BZ32; A0A8C9I594; A0A8C9J767; A0A8C9USK8; A0A8D0FX24; A0A8D2B3E9; A0A8D2EVN1; A0A8D2GXX0; A0A8D2P6S2; A0A8I3N9K0; A0A8K1G105; A0A8U0NH48; A0A8U7NRV1; A0A9B0X0S4; A0A9F2WGG8; A0A9V1E7C8; A0A9W3GX28; A0A9X9LVU0; A0AA35K0A2; A5D9A3; A6KT85; aju:106966617; amj:102568349; asn:102382532; B1B178; bacu:103014346; bta:615087; caty:105600022; ccan:109693530; cdk:105087494; cfa:474830; cfr:102506772; cge:100689091; chx:102168953; cpoc:100718713; csab:103221819; csyr:103261319; dle:111170669; dord:105996956; F6TYN8; F7F082; fca:101095657; G1LKN6; G1R063; G3HQP8; G3SB76; gga:396254; ggo:101129890; gsh:117346094; hsa:203068; I3ND93; J3S5D8; L5KK71; M3X7Z9; maua:101827904; mcal:110312171; mcc:574113; mdo:100022562; mmu:22154; mmur:105855398; mni:105498618; mpuf:101674529; muo:115466267; nasi:112395403; nle:100598146; nss:113423183; nsu:110586671; oas:100303606; oro:101365832; P05218; P07437; P09244; P69893; P69895; P69897; P99024; pale:102882060; panu:100998701; pbi:103053177; pcad:102979859; pcoq:105817283; pdic:114493854; pgut:117667950; pon:100172938; ptg:102963307; ptr:471960; pvp:105308138; pvt:110090161; Q1XHT6; Q2KJD0; Q3TFB6; Q3THH9; Q3TIL1; Q3UAV4; Q3UF52; Q5R943; Q5SU16; Q5TM69; Q6P9X8; Q767L7; Q7JJU6; Q8WUC1; Q9CY33; ray:107498082; rbb:108520633; rbb:108522550; rno:29214; rro:104666199; S9WJD1; sbq:101034943; shr:100918219; ssc:733686; T1DHR5; tmu:101341456; tsr:106553108; U3FAQ9; U3FM57; umr:103665004; vpc:102536943; vvp:112913571; W5PPT6; zca:113927996" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Opioid receptor pathways; Alzheimer's disease; HDAC6 interactions in the central nervous system" "Potential therapeutics for SARS; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Neutrophil degranulation; Neutrophil degranulation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Neutrophil degranulation; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; Neutrophil degranulation; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; Neutrophil degranulation; Regulation of PLK1 Activity at G2/M Transition; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Neutrophil degranulation; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2" "57" "12" "0.951" "0.952" "0.969" "0.951" "0.927" "0.835" "0.816" "0.825" "0.725" "4967.6" "4725.1" "4730.7" "4815.4" "4726.1" "4605.0" "4146.0" "4051.6" "4099.0" "3599.1" "" "" "" "" "" "" "" "" "" "" "2630.4" "2619.7" "2709.3" "2217.7" "2557.0" "2561.5" "2440.1" "2211.6" "2299.4" "3599.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7576515921520274560" "False" "High" "IsMasterProtein" "P13667" "Protein disulfide-isomerase A4 OS=Homo sapiens OX=9606 GN=PDIA4 PE=1 SV=2" "0.000" "False" "93.645" "37" "22" "36" "22" "645" "72.9" "5.07" "86.24" "22" "protein metabolism;other metabolic processes;stress response;transport" "non-structural extracellular;ER/Golgi;other cell component" "other molecular function" "Pf00085, Pf13848" "9601" "ENSG00000155660" "PDIA4" "A8K4K6; hsa:9601; P13667; Q549T6" "" "" "0" "0" "0.966" "0.983" "0.886" "0.933" "0.978" "0.886" "0.881" "1.000" "2.073" "3709.7" "3582.1" "3646.1" "3287.5" "3462.3" "3626.9" "3286.1" "3267.4" "3708.8" "7689.5" "" "" "" "" "" "" "" "" "" "" "1964.3" "1986.0" "2088.1" "1514.0" "1873.3" "2017.5" "1934.0" "1783.5" "2080.5" "7689.5" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7834140751544997544" "False" "High" "IsMasterProtein" "Q7Z6Z7" "E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens OX=9606 GN=HUWE1 PE=1 SV=3" "0.000" "False" "93.421" "6" "24" "34" "24" "4374" "481.6" "5.22" "83.72" "24" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00627, Pf00632, Pf02825, Pf06012, Pf06025, Pf14377" "10075" "ENSG00000086758" "HUWE1" "hsa:10075; O15029; Q4G2Z2; Q5H961; Q6P4D0; Q7Z6Z7; Q8NG67; Q9BUI0; Q9HCJ4; Q9NSL6; Q9P0A9" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neutrophil degranulation" "2" "0" "0.994" "0.985" "1.012" "0.976" "1.001" "0.876" "0.835" "0.836" "1.440" "1829.7" "1818.1" "1802.8" "1852.4" "1786.7" "1832.3" "1603.3" "1528.3" "1529.8" "2634.4" "" "" "" "" "" "" "" "" "" "" "968.8" "1008.0" "1032.5" "853.1" "966.7" "1019.2" "943.6" "834.3" "858.2" "2634.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7200124319077870265" "False" "High" "IsMasterProtein" "P35998" "26S proteasome regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PSMC2 PE=1 SV=3" "0.000" "False" "91.934" "34" "15" "29" "15" "433" "48.6" "5.95" "85.84" "15" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf17862, Pf21236" "5701" "ENSG00000161057" "PSMC2" "A4D0Q1; B7Z5E2; hsa:5701; P35998; Q3LIA5; Q9UDI3" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Neutrophil degranulation; UCH proteinases; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "0.991" "0.927" "1.017" "1.019" "0.980" "0.895" "0.866" "0.855" "0.589" "2167.7" "2147.3" "2008.5" "2205.1" "2209.0" "2124.9" "1941.1" "1877.5" "1853.2" "1277.8" "" "" "" "" "" "" "" "" "" "" "1147.8" "1190.5" "1150.3" "1015.5" "1195.2" "1181.9" "1142.4" "1024.8" "1039.6" "1277.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-806880739347862445" "False" "High" "IsMasterProtein" "Q71U36" "Tubulin alpha-1A chain OS=Homo sapiens OX=9606 GN=TUBA1A PE=1 SV=1" "0.000" "False" "91.599" "37" "13" "72" "1" "451" "50.1" "5.06" "205.26" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "7846" "ENSG00000167552" "TUBA1A" "A8K0B8; G3V1U9; hsa:7846; P04687; P05209; Q71U36" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease; PAFAH1B1 copy number variation" "COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Kinesins; The role of GTSE1 in G2/M progression after G2 checkpoint; HCMV Early Events; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; PKR-mediated signaling; Recycling pathway of L1; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; COPI-mediated anterograde transport; Intraflagellar transport; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "42" "0" "1.022" "0.866" "1.076" "1.025" "1.067" "1.034" "0.883" "0.784" "0.725" "125.6" "128.4" "108.8" "135.2" "128.8" "134.1" "130.0" "111.0" "98.5" "91.1" "" "" "" "" "" "" "" "" "" "" "66.5" "71.2" "62.3" "62.3" "69.7" "74.6" "76.5" "60.6" "55.2" "91.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5646758734319931850" "False" "High" "IsMasterProtein" "Q16555" "Dihydropyrimidinase-related protein 2 OS=Homo sapiens OX=9606 GN=DPYSL2 PE=1 SV=1" "0.000" "False" "91.180" "36" "16" "44" "16" "572" "62.3" "6.38" "128.73" "16" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "other molecular function" "Pf01979" "1808" "ENSG00000092964" "DPYSL2" "A8K5H2; B4DR31; D3DSS7; hsa:1808; O00424; Q16555" "Microtubule cytoskeleton regulation; Brain-derived neurotrophic factor (BDNF) signaling pathway" "Recycling pathway of L1; CRMPs in Sema3A signaling" "4" "0" "0.995" "0.969" "1.007" "0.993" "0.981" "0.972" "0.987" "1.049" "0.702" "2168.0" "2157.2" "2101.4" "2183.4" "2153.7" "2127.3" "2107.6" "2139.2" "2274.6" "1522.8" "" "" "" "" "" "" "" "" "" "" "1148.0" "1196.0" "1203.5" "1005.5" "1165.3" "1183.3" "1240.4" "1167.7" "1276.0" "1522.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "627927697280554035" "False" "High" "IsMasterProtein" "O60841" "Eukaryotic translation initiation factor 5B OS=Homo sapiens OX=9606 GN=EIF5B PE=1 SV=4" "0.000" "False" "90.992" "19" "19" "27" "19" "1220" "138.7" "5.49" "72.52" "19" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf11987, Pf14578" "9669" "ENSG00000158417" "EIF5B" "hsa:9669; O60841; O95805; Q53RV7; Q53SI8; Q9UF81; Q9UMN7" "Translation factors; Ciliary landscape" "GTP hydrolysis and joining of the 60S ribosomal subunit" "3" "0" "0.983" "1.037" "1.080" "1.066" "1.043" "1.332" "1.371" "1.363" "1.147" "2225.3" "2187.2" "2306.7" "2402.8" "2373.1" "2320.0" "2965.1" "3051.4" "3034.0" "2553.2" "" "" "" "" "" "" "" "" "" "" "1178.3" "1212.6" "1321.0" "1106.6" "1283.9" "1290.5" "1745.0" "1665.6" "1702.0" "2553.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6576828257658518084" "False" "High" "IsMasterProtein" "Q9BQE3" "Tubulin alpha-1C chain OS=Homo sapiens OX=9606 GN=TUBA1C PE=1 SV=1" "0.000" "False" "90.752" "37" "13" "67" "1" "449" "49.9" "5.10" "200.70" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "84790" "ENSG00000167553" "TUBA1C" "hsa:84790; Q9BQE3" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling; Alzheimer's disease; HDAC6 interactions in the central nervous system" "HCMV Early Events; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Recruitment of NuMA to mitotic centrosomes; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Intraflagellar transport; Recycling pathway of L1; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "37" "10" "0.983" "0.981" "0.904" "0.999" "1.014" "0.842" "0.813" "0.950" "0.753" "4353.6" "4281.2" "4272.3" "3935.3" "4349.7" "4415.0" "3663.9" "3541.6" "4135.6" "3276.8" "" "" "" "" "" "" "" "" "" "" "2305.2" "2373.6" "2446.7" "1812.3" "2353.3" "2455.8" "2156.3" "1933.2" "2320.0" "3276.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3973589334991488607" "False" "High" "IsMasterProtein" "Cont_P04264" "Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6" "0.000" "True" "90.739" "27" "17" "28" "14" "644" "66.0" "8.12" "89.53" "17" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;other molecular function" "Pf00038, Pf16208, Pf16210" "3848" "ENSG00000167768" "KRT1" "B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298" "Corticotropin-releasing hormone signaling pathway" "Formation of the cornified envelope; Neutrophil degranulation" "4" "3" "0.873" "0.415" "0.248" "0.295" "0.609" "0.891" "0.615" "0.174" "0.405" "6130.6" "5353.6" "2542.3" "1523.4" "1810.0" "3732.4" "5462.1" "3767.9" "1065.2" "2483.9" "" "" "" "" "" "" "" "" "" "" "3246.1" "2968.2" "1456.0" "701.6" "979.3" "2076.1" "3214.6" "2056.7" "597.6" "2483.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-951770295276680131" "False" "High" "IsMasterProtein" "P09874" "Poly [ADP-ribose] polymerase 1 OS=Homo sapiens OX=9606 GN=PARP1 PE=1 SV=4" "0.000" "False" "90.625" "18" "17" "27" "17" "1014" "113.0" "8.88" "80.94" "17" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00533, Pf00644, Pf00645, Pf02877, Pf05406, Pf08063, Pf21728" "142" "ENSG00000143799" "PARP1" "B1ANJ4; hsa:142; P09874; Q8IUZ9" "Corticotropin-releasing hormone signaling pathway; Nanoparticle triggered regulated necrosis; Fas ligand pathway and stress induction of heat shock proteins; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Breast cancer pathway; Acute viral myocarditis; Joubert syndrome; Male infertility; Base excision repair; IL-18 signaling pathway; DNA repair pathways, full network; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Progeria-associated lipodystrophy; Primary ovarian insufficiency; Macrophage-stimulating protein (MSP) signaling network map" "SUMOylation of DNA damage response and repair proteins; Downregulation of SMAD2/3:SMAD4 transcriptional activity; HDR through MMEJ (alt-NHEJ); Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; vRNA Synthesis; POLB-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER" "25" "0" "0.968" "0.979" "1.199" "1.156" "1.115" "1.507" "1.055" "1.582" "12.937" "796.9" "771.7" "779.9" "955.9" "921.6" "888.2" "1200.9" "840.5" "1260.8" "10309.9" "" "" "" "" "" "" "" "" "" "" "422.0" "427.8" "446.6" "440.2" "498.6" "494.1" "706.8" "458.8" "707.3" "10309.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7970699774180839953" "False" "High" "IsMasterProtein" "Q9Y230" "RuvB-like 2 OS=Homo sapiens OX=9606 GN=RUVBL2 PE=1 SV=3" "0.000" "False" "90.621" "40" "16" "39" "16" "463" "51.1" "5.64" "92.66" "16" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06068, Pf17856" "10856" "ENSG00000183207" "RUVBL2" "B3KQ59; E7ETE5; hsa:10856; Q6FIB9; Q6PK27; Q9Y230; Q9Y361" "" "HATs acetylate histones; Telomere Extension By Telomerase" "2" "0" "1.037" "1.005" "1.089" "1.052" "1.115" "1.089" "1.065" "1.094" "0.923" "2052.1" "2128.9" "2061.7" "2235.7" "2158.0" "2288.4" "2235.7" "2185.7" "2245.5" "1894.8" "" "" "" "" "" "" "" "" "" "" "1086.6" "1180.3" "1180.7" "1029.6" "1167.5" "1272.9" "1315.8" "1193.1" "1259.7" "1894.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1156142612126302656" "False" "High" "IsMasterProtein" "P07814" "Bifunctional glutamate/proline--tRNA ligase OS=Homo sapiens OX=9606 GN=EPRS1 PE=1 SV=5" "0.000" "False" "90.480" "15" "23" "30" "23" "1512" "170.5" "7.33" "84.70" "23" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00458, Pf00587, Pf00749, Pf03129, Pf03950, Pf09180, Pf20974" "2058" "ENSG00000136628" "EPRS1" "A0AVA9; B9EGH3; hsa:2058; P07814; Q05BP6; Q05DF8; Q5DSM1; Q5H9S5; Q6PD57; Q86X73" "Parkinson's disease pathway; VEGFA-VEGFR2 signaling; Amino acid metabolism" "tRNA modification in the nucleus and cytosol; Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "6" "0" "1.010" "1.018" "1.052" "1.030" "1.071" "1.071" "0.593" "1.004" "5.591" "1880.4" "1898.3" "1915.1" "1977.8" "1936.4" "2013.8" "2013.6" "1115.9" "1887.5" "10513.8" "" "" "" "" "" "" "" "" "" "" "995.7" "1052.5" "1096.8" "910.8" "1047.6" "1120.1" "1185.1" "609.1" "1058.8" "10513.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6625337675714682058" "False" "High" "IsMasterProtein" "P33176" "Kinesin-1 heavy chain OS=Homo sapiens OX=9606 GN=KIF5B PE=1 SV=1" "0.000" "False" "90.194" "26" "22" "35" "22" "963" "109.6" "6.51" "81.37" "22" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "3799" "ENSG00000170759" "KIF5B" "A0AVB2; hsa:3799; P33176; Q5VZ85" "Alzheimer's disease and miRNA effects; Envelope proteins and their potential roles in EDMD physiopathology; Insulin signaling; CCL18 signaling pathway; Alzheimer's disease" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Signaling by ALK fusions and activated point mutants; Insulin processing; RHO GTPases activate KTN1" "11" "0" "1.006" "0.993" "0.980" "1.039" "1.049" "0.846" "0.894" "0.905" "0.722" "1897.9" "1909.0" "1884.0" "1860.2" "1971.9" "1990.2" "1606.0" "1696.3" "1717.1" "1369.4" "" "" "" "" "" "" "" "" "" "" "1004.9" "1058.4" "1079.0" "856.7" "1066.9" "1107.0" "945.2" "925.9" "963.3" "1369.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-795610127174802190" "False" "High" "IsMasterProtein" "P15311" "Ezrin OS=Homo sapiens OX=9606 GN=EZR PE=1 SV=4" "0.000" "False" "88.604" "30" "22" "59" "17" "586" "69.4" "6.27" "153.82" "22" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "7430" "ENSG00000092820" "EZR" "E1P5A8; hsa:7430; P15311; P23714; Q4VX75; Q96CU8; Q9NSJ4" "Pathogenic Escherichia coli infection; AGE/RAGE pathway; VEGFA-VEGFR2 signaling; 16p11.2 proximal deletion syndrome; CCL18 signaling pathway; Regulation of actin cytoskeleton; GDNF signaling" "Sensory processing of sound by outer hair cells of the cochlea; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Netrin-1 signaling" "11" "1" "0.985" "1.021" "1.016" "0.945" "0.932" "0.972" "1.089" "0.944" "0.704" "4023.2" "3963.0" "4108.1" "4087.8" "3802.6" "3750.6" "3910.3" "4381.4" "3796.4" "2833.7" "" "" "" "" "" "" "" "" "" "" "2130.3" "2197.2" "2352.7" "1882.6" "2057.4" "2086.3" "2301.4" "2391.6" "2129.7" "2833.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3977231737757699064" "False" "High" "IsMasterProtein" "Q6JBY9" "CapZ-interacting protein OS=Homo sapiens OX=9606 GN=RCSD1 PE=1 SV=1" "0.000" "False" "88.177" "49" "18" "37" "18" "416" "44.5" "5.40" "121.60" "18" "stress response;transport;other biological processes" "cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf05177, Pf15255" "92241" "ENSG00000198771" "RCSD1" "B1AK48; hsa:92241; Q4G0E7; Q6IN93; Q6JBY9; Q8IZM2; Q96DX0; Q9NST4" "" "" "0" "0" "0.891" "1.049" "0.993" "0.847" "0.888" "0.814" "0.891" "0.833" "0.453" "5343.2" "4761.5" "5605.2" "5305.6" "4524.6" "4747.2" "4350.0" "4758.5" "4449.2" "2420.9" "" "" "" "" "" "" "" "" "" "" "2829.2" "2639.9" "3210.1" "2443.4" "2448.0" "2640.6" "2560.1" "2597.4" "2495.9" "2420.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5211801014996619812" "False" "High" "IsMasterProtein" "O43143" "ATP-dependent RNA helicase DHX15 OS=Homo sapiens OX=9606 GN=DHX15 PE=1 SV=2" "0.000" "False" "87.956" "28" "21" "40" "21" "795" "90.9" "7.46" "99.74" "21" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "1665" "ENSG00000109606" "DHX15" "hsa:1665; O43143; Q9NQT7" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.986" "0.930" "0.971" "1.007" "0.976" "0.978" "0.973" "1.054" "0.541" "4015.5" "3960.2" "3734.2" "3899.6" "4042.5" "3917.7" "3926.2" "3906.7" "4232.1" "2171.0" "" "" "" "" "" "" "" "" "" "" "2126.2" "2195.6" "2138.6" "1795.9" "2187.2" "2179.2" "2310.7" "2132.5" "2374.1" "2171.0" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3249429330709182822" "False" "High" "IsMasterProtein" "Cont_P68138" "Actin, alpha skeletal muscle OS=Bos taurus OX=9913 GN=ACTA1 PE=1 SV=1" "0.000" "True" "87.887" "40" "15" "168" "3" "377" "42.0" "5.39" "439.19" "15" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "100065454; 100154254; 100172818; 100395910; 100426612; 100542212; 100566789; 100609865; 100661558; 100716933; 100926492; 100955023; 100987270; 101018268; 101107662; 101316902; 101345310; 101371004; 101561057; 101607063; 101822895; 101878061; 101942538; 101972057; 102017886; 102121165; 102446120; 102836098; 102922102; 102943964; 103051164; 103127961; 103195041; 103624093; 103744113; 103818506; 104131026; 104291844; 104300855; 104488844; 104860683; 104987264; 105499142; 105505494; 105722343; 105823179; 105871143; 106543751; 106843698; 108498591; 108537854; 109248958; 109372851; 109689807; 11459; 281592; 29437; 58" "ENSABRG00000018240; ENSACAG00000001104; ENSACCG00020004955; ENSACDG00005004064; ENSACOG00000015573; ENSAMEG00000005186; ENSANAG00000033052; ENSANIG00000015411; ENSAOWG00000018027; ENSAPLG00000004146; ENSAPLG00020002125; ENSBGRG00000020862; ENSBIXG00000012362; ENSBIXG00005025901; ENSBMSG00010014761; ENSBTAG00000046332; ENSCABG00000013181; ENSCAFG00000008253; ENSCAFG00020027254; ENSCAFG00030012637; ENSCANG00000033017; ENSCCAG00000035682; ENSCCNG00000030664; ENSCGRG00001016859; ENSCJAG00000011114; ENSCLAG00000003307; ENSCMMG00000014710; ENSCMUG00000000473; ENSCPBG00000006129; ENSCPGG00000000824; ENSCPIG00010005220; ENSCPOG00000032187; ENSCPVG00000014620; ENSCSRG00000013784; ENSCUSG00005000547; ENSCWAG00000013028; ENSDLEG00000008382; ENSDNVG00000014331; ENSEASG00005031337; ENSEGOG00005009171; ENSFCAG00000030433; ENSFDAG00000018383; ENSFTIG00000004572; ENSG00000143632; ENSGAGG00000007922; ENSGEVG00005016044; ENSJHYG00000007552; ENSJJAG00000019369; ENSLAFG00000006306; ENSLCNG00005015654; ENSLLTG00000003642; ENSMCSG00000014926; ENSMFAG00000002280; ENSMGAG00000012010; ENSMICG00000007460; ENSMMNG00015014953; ENSMMSG00000010015; ENSMMUG00000022086; ENSMNEG00000003684; ENSMSIG00000009031; ENSMUNG00000016766; ENSMUSG00000031972; ENSNGAG00000008844; ENSNVIG00000023437; ENSOANG00000012845; ENSOARG00000003044; ENSOGAG00000016005; ENSOSUG00000015814; ENSPANG00000005524; ENSPCEG00000011384; ENSPCLG00000000773; ENSPCOG00000022008; ENSPCTG00005016061; ENSPEMG00000019882; ENSPLOG00000020512; ENSPMRG00000005431; ENSPPAG00000033916; ENSPPYG00000000127; ENSPSIG00000002854; ENSPSNG00000011648; ENSPSTG00000017705; ENSPTRG00000002086; ENSRBIG00000037124; ENSRFEG00010013727; ENSRNOG00000017786; ENSRNOG00055021900; ENSRNOG00060017592; ENSRNOG00065018197; ENSSCAG00000003577; ENSSHAG00000014035; ENSSHBG00005006730; ENSSMRG00000022024; ENSSOCG00000011564; ENSSSCG00000010190; ENSSSCG00015047339; ENSSSCG00040044916; ENSSSCG00055024685; ENSSSCG00065076746; ENSSSUG00005003524; ENSSTOG00000024222; ENSSVLG00005008349; ENSTGEG00000010273; ENSTGUG00000010041; ENSUAMG00000015031; ENSUPAG00010000311; ENSVKKG00000017431; ENSVURG00010000907; ENSVURG00010001203" "Acta1; ACTA1; LOC101345310; LOC101878061; LOC103127961; LOC103661861; LOC111160482; LOC112807841" "A0A090BWQ4; A0A091DQ28; A0A091EBT4; A0A091GSF2; A0A091GVU0; A0A091JKH4; A0A093GLM6; A0A096N2Y2; A0A098M1X6; A0A0A0AU99; A0A1S3APV3; A0A1U7QEW4; A0A1W7RJM3; A0A218VBM4; A0A226MSL5; A0A250XZP0; A0A2I0UAK3; A0A2J8M6H1; A0A2J8R810; A0A2K5EBS2; A0A2K5IRF2; A0A2K5S578; A0A2K5TYP0; A0A2K6ANM2; A0A2K6G1G8; A0A2K6LSJ0; A0A2P4SXB1; A0A2R9AZU8; A0A2U3W9D6; A0A2U4BVD6; A0A2Y9E0P7; A0A2Y9HE43; A0A2Y9L6W7; A0A2Y9LGX2; A0A2Y9S7L7; A0A3L7I1B1; A0A3L8S8G5; A0A3M0KHK7; A0A3Q7NT51; A0A452H615; A0A452RJE1; A0A480QNI6; A0A4U1EEU3; A0A4W2GZT5; A0A4X2JWN6; A0A5J5MT96; A0A5N3VLN8; A0A663E501; A0A667HAA9; A0A669PGX8; A0A670I895; A0A671F3Z0; A0A672U2N2; A0A673SW94; A0A6B2F569; A0A6B2F5D9; A0A6D2XHK8; A0A6I9M0F0; A0A6I9XXG7; A0A6J0HG37; A0A6J0T852; A0A6J1U9U4; A0A6J1YDW3; A0A6J2GP26; A0A6J2NA43; A0A6J3CTV5; A0A6J3EY96; A0A6P3ERW2; A0A6P3FJ88; A0A6P3HAS4; A0A6P5LDM6; A0A6P9CIM0; A0A6P9EZA5; A0A7J7EZ09; A0A7J7RJI6; A0A7J7RTV4; A0A7J8B841; A0A7J8BL15; A0A7K4JPE4; A0A7K4PSI7; A0A7K4QY10; A0A7K4RLR4; A0A7K4UDE9; A0A7K4UY42; A0A7K4W696; A0A7K4XA22; A0A7K4Y8W8; A0A7K4ZFF1; A0A7K5BDX3; A0A7K5D428; A0A7K5GNW3; A0A7K5HRK1; A0A7K5IK78; A0A7K5JXK4; A0A7K5KX43; A0A7K5MSI7; A0A7K5NP28; A0A7K5PKH5; A0A7K5QIU3; A0A7K5S142; A0A7K5SPK9; A0A7K5UC76; A0A7K5W8H5; A0A7K5XD37; A0A7K5Y7M0; A0A7K5ZW11; A0A7K6B2F8; A0A7K6BQV7; A0A7K6DCL1; A0A7K6EXZ1; A0A7K6FLR8; A0A7K6GNU4; A0A7K6HR31; A0A7K6J4T9; A0A7K6K4L6; A0A7K6LWQ9; A0A7K6M0L3; A0A7K6P948; A0A7K6RCV4; A0A7K6TEI2; A0A7K6VY88; A0A7K6XPH0; A0A7K6Z9M8; A0A7K6ZR93; A0A7K7AYM3; A0A7K7C659; A0A7K7DZL3; A0A7K7EWS4; A0A7K7G760; A0A7K7IH73; A0A7K7KDI8; A0A7K7KKJ6; A0A7K7MNF7; A0A7K7NEW8; A0A7K7PM04; A0A7K7QH90; A0A7K7RDG5; A0A7K7TAJ1; A0A7K7U609; A0A7K7XKX1; A0A7K8AQB9; A0A7K8BQL5; A0A7K8CRX7; A0A7K8EFR7; A0A7K8FRF9; A0A7K8GQ26; A0A7K8HWN9; A0A7K8ISA9; A0A7K8JPZ4; A0A7K8KS65; A0A7K8M0C5; A0A7K8N2Y9; A0A7K8PDY4; A0A7K8QME0; A0A7K8S6K4; A0A7K8T8U7; A0A7K8U5E0; A0A7K8VJC8; A0A7K8WMV3; A0A7K8Y2D4; A0A7K8YWW6; A0A7K8ZV32; A0A7K9AJ30; A0A7K9BS34; A0A7K9D6V1; A0A7K9EI05; A0A7K9FLR9; A0A7K9I701; A0A7K9IMC9; A0A7K9KC93; A0A7K9MVB8; A0A7K9NB46; A0A7K9PEG9; A0A7K9RST5; A0A7K9TK91; A0A7K9V843; A0A7K9W2K2; A0A7K9WX62; A0A7L0AFU5; A0A7L0BDS5; A0A7L0CIB3; A0A7L0EPL5; A0A7L0FCD1; A0A7L0G7Q5; A0A7L0HND8; A0A7L0II88; A0A7L0KT22; A0A7L0LSN2; A0A7L0NLS0; A0A7L0P7X4; A0A7L0RUG0; A0A7L0SJQ9; A0A7L0UGT7; A0A7L0XTP2; A0A7L0ZS39; A0A7L1B939; A0A7L1BT59; A0A7L1DMI6; A0A7L1DWR3; A0A7L1F253; A0A7L1GIR7; A0A7L1HPS8; A0A7L1IC62; A0A7L1K5Y1; A0A7L1L5V3; A0A7L1M7T5; A0A7L1NKU4; A0A7L1R8Z0; A0A7L1T000; A0A7L1U068; A0A7L1XCH6; A0A7L1YLD6; A0A7L2B7P4; A0A7L2BR48; A0A7L2CKL5; A0A7L2ESG9; A0A7L2FHP9; A0A7L2FY76; A0A7L2HHD4; A0A7L2IA74; A0A7L2JHG8; A0A7L2KMU3; A0A7L2LNS8; A0A7L2P8R5; A0A7L2QEC4; A0A7L2RU84; A0A7L2TB66; A0A7L2UV13; A0A7L2XQZ8; A0A7L2Z1X6; A0A7L2ZLP6; A0A7L3CN30; A0A7L3D9C1; A0A7L3GMY1; A0A7L3GYG9; A0A7L3ID24; A0A7L3IXN1; A0A7L3KUM5; A0A7L3LJJ7; A0A7L3M3X9; A0A7L3PPQ0; A0A7L3QHZ1; A0A7L3RH67; A0A7L3SGI7; A0A7L3U4P6; A0A7L3VNT2; A0A7L3WD55; A0A7L3Y1G6; A0A7L3YVD7; A0A7L3ZS54; A0A7L4AN29; A0A7L4CQM9; A0A7L4D5C7; A0A7L4DZI8; A0A7L4G527; A0A7L4GV55; A0A7L4IYY1; A0A7L4JN17; A0A7L4KJ61; A0A7L4MPA2; A0A7L4NEP2; A0A835NXC8; A0A850U7W3; A0A850V3D3; A0A850XEM6; A0A850Y843; A0A850ZDL2; A0A851BEY3; A0A851CN67; A0A851DTB7; A0A851EK28; A0A851FDE8; A0A851J837; A0A851KA41; A0A851LW39; A0A851NRY4; A0A851QJ25; A0A851RNA5; A0A851U848; A0A851VUC7; A0A851WKT2; A0A851XT74; A0A851YL06; A0A851ZBL2; A0A852BHA9; A0A852CRR6; A0A852D425; A0A852E1V9; A0A852F792; A0A852GJG7; A0A852IBF3; A0A852JDC5; A0A852JR42; A0A852KVX0; A0A852LXY4; A0A852NS61; A0A8B6ZNK4; A0A8B7GBR5; A0A8B7Q300; A0A8B8TZT0; A0A8B9CLG9; A0A8B9DEA1; A0A8B9GFW6; A0A8B9NJE6; A0A8B9QKT1; A0A8B9SHJ3; A0A8B9Y7Y7; A0A8C0DED2; A0A8C0H293; A0A8C0LYE1; A0A8C0N2I3; A0A8C2UWB6; A0A8C3CSU8; A0A8C3FFU4; A0A8C3L8M1; A0A8C3PH13; A0A8C3QCR3; A0A8C3SQW8; A0A8C3TNI9; A0A8C3WY11; A0A8C4PR70; A0A8C4U1I2; A0A8C4YAW6; A0A8C5IXG8; A0A8C5P2E0; A0A8C5RKR8; A0A8C5UFH7; A0A8C6FKL7; A0A8C6GS76; A0A8C6NGV1; A0A8C6QM24; A0A8C7BWL1; A0A8C8BUD5; A0A8C8S3P8; A0A8C8Y8T7; A0A8C9C427; A0A8C9LFS5; A0A8C9MJH4; A0A8D0E9T9; A0A8D0FGF9; A0A8D2B3M6; A0A8D2F0S7; A0A8D2GFE7; A0A8D2LUT0; A0A8J4MUQ6; A0A8J4N2X1; A0A8J4NK31; A0A8J4NVY9; A0A8J4PAG4; A0A8K0BNH4; A0A8K1LSE9; A0A8M1FCK6; A0A8P0NAG9; A0A8S9F5P5; A0A8U0V7M2; A0A9B0WSP0; A0A9F2KUS3; A0A9Q0Y593; A0A9V1E5M8; A0AA35K559; A0AA40L2Y5; A0AA41N2J4; acs:100566789; aful:116488210; aju:106984378; bbis:104987264; brhi:104488844; bta:281592; cang:105505494; cbrc:103624093; ccan:109689807; cfr:102507445; cjc:100395910; cmy:102943964; cpic:101942538; cpoc:100716933; cuca:104060336; cvf:104291844; dle:111163953; dpub:104300855; ecb:100065454; egz:104131026; elk:111160482; F7E1F2; F7FWZ0; F7HNV4; G1K932; G1LEZ5; G1NHJ8; G3SXX7; G3WM41; gga:421534; H0UXP6; H0XEG0; H0ZIF5; H2Q1A9; hai:109372851; hsa:58; I3N266; J3SBR4; K7F4I9; lav:100661558; M3XC93; M7AKZ6; maua:101822895; mcc:100426612; mcf:102121165; mgp:100542212; mmu:11459; mmur:105871143; mni:105499142; ngi:103744113; nss:113413315; nsu:110582311; oas:101107662; oga:100955023; oro:101371004; P02568; P68133; P68134; P68135; P68136; P68137; P68138; P68139; P99020; panu:101018268; pbi:103051164; pcad:102976743; pcoq:105823179; pcw:110217891; pdic:114512380; pgut:117672003; pon:100172818; pps:100987270; pss:102446120; ptr:100609865; pvt:110075363; Q3ZCG3; Q5R9Q5; Q5T8M9; rbb:108537854; rno:29437; scan:103818506; shr:100926492; ssc:100154254; T1E7F6; tmu:101345310; tsr:106543751; U3EUL6; U3I8T6; umr:103661861; V8NV61; W5NYJ1; zca:113923883" "FAS pathway and stress induction of HSP regulation; Hypothetical network for drug addiction; Myometrial relaxation and contraction pathways; Myometrial relaxation and contraction pathways; Fas ligand pathway and stress induction of heat shock proteins; Striated muscle contraction; Myometrial relaxation and contraction pathways; Physico-chemical features and toxicity-associated pathways; Striated muscle contraction pathway; Myometrial relaxation and contraction pathways; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; IL-18 signaling pathway; Burn wound healing; Pleural mesothelioma; Comprehensive IL-17A signaling; Striated muscle contraction" "Striated Muscle Contraction; Striated Muscle Contraction; Striated Muscle Contraction; Striated Muscle Contraction; Striated Muscle Contraction; Striated Muscle Contraction" "22" "0" "0.959" "1.115" "0.949" "0.981" "1.099" "0.963" "1.131" "0.932" "0.517" "331.9" "318.4" "370.2" "315.1" "325.5" "364.7" "319.7" "375.3" "309.5" "171.4" "" "" "" "" "" "" "" "" "" "" "175.8" "176.5" "212.0" "145.1" "176.1" "202.8" "188.2" "204.9" "173.6" "171.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4595887854081889880" "False" "High" "IsMasterProtein" "Q99460" "26S proteasome non-ATPase regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PSMD1 PE=1 SV=2" "0.000" "False" "87.791" "24" "19" "32" "19" "953" "105.8" "5.39" "84.85" "19" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf01851, Pf13646, Pf18004, Pf21505" "5707" "ENSG00000173692" "PSMD1" "B8ZZH9; hsa:5707; Q24JU0; Q53TI2; Q6GMU5; Q6P2P4; Q6PJM7; Q6PKG9; Q86VU1; Q8IV79; Q99460" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Downstream TCR signaling; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; KEAP1-NFE2L2 pathway; Orc1 removal from chromatin; Assembly of the pre-replicative complex; Separation of Sister Chromatids; Neutrophil degranulation; Regulation of expression of SLITs and ROBOs; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Somitogenesis; Cross-presentation of soluble exogenous antigens (endosomes); Regulation of ornithine decarboxylase (ODC)" "64" "0" "0.976" "0.946" "0.961" "0.986" "0.980" "0.907" "0.901" "0.924" "0.610" "3065.0" "2992.0" "2898.2" "2945.7" "3023.5" "3003.3" "2781.0" "2761.1" "2830.9" "1869.6" "" "" "" "" "" "" "" "" "" "" "1622.9" "1658.8" "1659.8" "1356.6" "1635.8" "1670.6" "1636.7" "1507.1" "1588.1" "1869.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4137218576109141814" "False" "High" "IsMasterProtein" "Q06210" "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 OS=Homo sapiens OX=9606 GN=GFPT1 PE=1 SV=3" "0.000" "False" "86.695" "31" "19" "33" "19" "699" "78.8" "7.11" "80.20" "19" "protein metabolism;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf01380, Pf13522" "2673" "ENSG00000198380" "GFPT1" "hsa:2673; Q06210; Q53QE6; Q9BXF8" "UDP-derived sugars synthesis in fibroblasts" "XBP1(S) activates chaperone genes; Synthesis of UDP-N-acetyl-glucosamine; Defective GFPT1 causes CMSTA1" "4" "0" "0.996" "0.952" "0.997" "1.023" "1.019" "0.910" "0.927" "0.895" "0.578" "2043.4" "2035.7" "1946.3" "2036.8" "2091.1" "2082.2" "1859.9" "1894.4" "1829.4" "1180.5" "" "" "" "" "" "" "" "" "" "" "1082.0" "1128.6" "1114.6" "938.0" "1131.4" "1158.2" "1094.6" "1034.1" "1026.2" "1180.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6605193621902288169" "False" "High" "IsMasterProtein" "Cont_P35908" "Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2" "0.000" "True" "86.200" "27" "16" "30" "13" "639" "65.4" "8.00" "86.52" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;cytoskeletal activity" "Pf00038, Pf16208" "3849" "ENSG00000172867" "KRT2" "hsa:3849; P35908; Q4VAQ2" "" "Formation of the cornified envelope" "2" "0" "0.660" "0.103" "0.116" "0.183" "0.167" "0.470" "0.336" "0.101" "0.177" "7032.6" "4644.4" "721.4" "812.8" "1284.7" "1172.1" "3303.6" "2360.1" "710.8" "1245.6" "" "" "" "" "" "" "" "" "" "" "3723.7" "2575.0" "413.2" "374.3" "695.1" "652.0" "1944.3" "1288.3" "398.8" "1245.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7989790464056543145" "False" "High" "IsMasterProtein" "Cont_P35527" "Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3" "0.000" "True" "85.454" "28" "15" "25" "14" "623" "62.0" "5.24" "75.94" "15" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf00038" "3857; 454664" "ENSG00000171403; ENSPTRG00000009169" "KRT9" "A0A2J8KG96; A0A6D2VYW7; H2QCZ6; hsa:3857; O00109; P35527; ptr:454664; Q0IJ47; Q14665" "" "Formation of the cornified envelope" "2" "0" "5.626" "1.072" "0.506" "0.617" "1.214" "1.481" "0.934" "0.461" "0.834" "1589.5" "8941.8" "1704.3" "804.2" "981.4" "1929.8" "2353.5" "1485.3" "732.9" "1326.2" "" "" "" "" "" "" "" "" "" "" "841.6" "4957.6" "976.1" "370.4" "531.0" "1073.4" "1385.1" "810.7" "411.1" "1326.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6441918618070782743" "False" "High" "IsMasterProtein" "P51610" "Host cell factor 1 OS=Homo sapiens OX=9606 GN=HCFC1 PE=1 SV=2" "0.000" "False" "85.387" "11" "18" "28" "18" "2035" "208.6" "7.46" "82.28" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01344, Pf13415, Pf13854" "3054" "ENSG00000172534" "HCFC1" "hsa:3054; P51610; Q6P4G5" "Mitochondrial gene expression; Pleural mesothelioma" "UCH proteinases; Formation of WDR5-containing histone-modifying complexes; Transcriptional activation of mitochondrial biogenesis; HATs acetylate histones" "6" "0" "1.002" "1.036" "0.996" "1.020" "1.040" "1.031" "1.184" "1.114" "0.828" "1910.7" "1914.7" "1979.2" "1903.2" "1948.8" "1987.7" "1969.7" "2261.7" "2129.1" "1582.0" "" "" "" "" "" "" "" "" "" "" "1011.7" "1061.6" "1133.5" "876.5" "1054.4" "1105.6" "1159.2" "1234.5" "1194.4" "1582.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5988193438521902409" "False" "High" "IsMasterProtein" "P26640" "Valine--tRNA ligase OS=Homo sapiens OX=9606 GN=VARS1 PE=1 SV=4" "0.000" "False" "85.126" "17" "19" "27" "19" "1264" "140.4" "7.59" "81.50" "19" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol" "other molecular function" "Pf00043, Pf00133, Pf08264" "7407" "ENSG00000096171; ENSG00000204394; ENSG00000224264; ENSG00000226589; ENSG00000231116" "VARS1" "B0V1N1; B4DZ61; hsa:7407; P26640; Q5JQ90; Q96E77; Q9UQM2" "Amino acid metabolism" "Cytosolic tRNA aminoacylation" "2" "0" "1.008" "0.960" "0.976" "1.061" "1.055" "0.939" "0.749" "0.893" "2.701" "1509.5" "1521.6" "1448.4" "1474.0" "1602.0" "1593.0" "1417.8" "1130.0" "1348.2" "4076.7" "" "" "" "" "" "" "" "" "" "" "799.3" "843.6" "829.5" "678.8" "866.8" "886.1" "834.4" "616.8" "756.3" "4076.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "562319574892213792" "False" "High" "IsMasterProtein" "P04406" "Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens OX=9606 GN=GAPDH PE=1 SV=3" "0.000" "False" "84.996" "45" "15" "92" "15" "335" "36.0" "8.46" "241.70" "15" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00044, Pf02800" "2597" "ENSG00000111640" "GAPDH" "E7EUT4; hsa:2597; P00354; P04406; Q53X65" "Cori cycle; Alzheimer's disease and miRNA effects; HIF1A and PPARG regulation of glycolysis; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; 7q11.23 copy number variation syndrome; Glycolysis in senescence; Alzheimer's disease; Sildenafil treatment; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; Sudden infant death syndrome (SIDS) susceptibility pathways" "Glycolysis; Gluconeogenesis" "16" "0" "0.944" "0.932" "0.897" "0.936" "1.056" "1.009" "0.912" "0.924" "0.575" "8508.8" "8031.3" "7934.1" "7631.5" "7960.3" "8989.2" "8582.4" "7760.8" "7859.2" "4895.8" "" "" "" "" "" "" "" "" "" "" "4505.4" "4452.8" "4543.8" "3514.6" "4306.8" "5000.2" "5051.0" "4236.2" "4408.8" "4895.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1074215629290594570" "False" "High" "IsMasterProtein" "P22626" "Heterogeneous nuclear ribonucleoproteins A2/B1 OS=Homo sapiens OX=9606 GN=HNRNPA2B1 PE=1 SV=2" "0.000" "False" "84.778" "46" "16" "80" "13" "353" "37.4" "8.95" "215.06" "16" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf11627" "3181" "ENSG00000122566" "HNRNPA2B1" "A0A024RA27; A0A024RA61; A8K064; hsa:3181; P22626; P22627; Q9UC98; Q9UDJ2" "mRNA processing" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "4" "2" "1.016" "1.008" "1.011" "0.990" "0.992" "0.973" "0.879" "1.012" "2.033" "4354.4" "4423.9" "4388.1" "4400.5" "4311.9" "4319.3" "4237.3" "3828.1" "4406.6" "8854.4" "" "" "" "" "" "" "" "" "" "" "2305.7" "2452.8" "2513.0" "2026.6" "2332.9" "2402.6" "2493.8" "2089.6" "2472.0" "8854.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3779865839115366179" "False" "High" "IsMasterProtein" "P00367" "Glutamate dehydrogenase 1, mitochondrial OS=Homo sapiens OX=9606 GN=GLUD1 PE=1 SV=2" "0.000" "False" "84.529" "31" "16" "40" "16" "558" "61.4" "7.80" "94.91" "16" "other metabolic processes;other biological processes" "mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00208, Pf02812" "2746" "ENSG00000148672" "GLUD1" "B3KV55; B4DGN5; hsa:2746; P00367; Q5TBU3" "VEGFA-VEGFR2 signaling; Amino acid metabolism; Metabolic reprogramming in colon cancer; 22q11.2 copy number variation syndrome; Amino acid metabolism pathway excerpt: histidine catabolism extension; 10q22q23 copy number variation" "Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein degradation; Glutamate and glutamine metabolism" "9" "0" "0.957" "0.969" "0.914" "0.934" "0.989" "0.913" "0.976" "0.936" "0.463" "4432.0" "4243.5" "4293.0" "4050.7" "4140.1" "4383.7" "4047.7" "4326.0" "4149.1" "2049.9" "" "" "" "" "" "" "" "" "" "" "2346.7" "2352.7" "2458.6" "1865.5" "2240.0" "2438.4" "2382.2" "2361.4" "2327.5" "2049.9" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4769002131436570839" "False" "High" "IsMasterProtein" "Q00610" "Clathrin heavy chain 1 OS=Homo sapiens OX=9606 GN=CLTC PE=1 SV=5" "0.000" "False" "84.346" "11" "19" "30" "19" "1675" "191.5" "5.69" "81.35" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00637, Pf01394, Pf09268, Pf13838" "1213" "ENSG00000141367" "CLTC" "D3DU00; hsa:1213; Q00610; Q6N0A0; Q86TF2" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; Dengue-2 interactions with complement and coagulation cascades; Ebola virus infection in host; Fragile X syndrome; 7q11.23 copy number variation syndrome; Complement and coagulation cascades" "ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Recycling pathway of L1; MHC class II antigen presentation; RHOV GTPase cycle; Lysosome Vesicle Biogenesis; RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; Entry of Influenza Virion into Host Cell via Endocytosis; Formation of annular gap junctions" "25" "0" "1.013" "0.977" "1.010" "1.036" "1.014" "1.073" "1.011" "1.034" "1.949" "2676.4" "2710.6" "2615.6" "2702.9" "2772.7" "2714.6" "2870.6" "2706.2" "2767.7" "5217.4" "" "" "" "" "" "" "" "" "" "" "1417.1" "1502.8" "1498.0" "1244.8" "1500.2" "1510.0" "1689.4" "1477.2" "1552.6" "5217.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6674387397432112473" "False" "High" "IsMasterProtein" "P68371" "Tubulin beta-4B chain OS=Homo sapiens OX=9606 GN=TUBB4B PE=1 SV=1" "0.000" "False" "83.552" "40" "15" "77" "3" "445" "49.8" "4.89" "165.45" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00091, Pf03953" "10383" "ENSG00000188229" "TUBB4B" "A2BFA2; hsa:10383; P05217; P68371" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "HCMV Early Events; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Neutrophil degranulation; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Intraflagellar transport; Recycling pathway of L1; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "42" "0" "0.969" "0.980" "0.984" "0.982" "0.957" "0.851" "0.910" "0.872" "0.602" "1290.9" "1250.8" "1264.5" "1270.0" "1267.6" "1234.9" "1098.0" "1174.5" "1125.8" "776.7" "" "" "" "" "" "" "" "" "" "" "683.6" "693.5" "724.2" "584.9" "685.8" "686.9" "646.2" "641.1" "631.5" "776.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2037005348220660879" "False" "High" "IsMasterProtein" "O00151" "PDZ and LIM domain protein 1 OS=Homo sapiens OX=9606 GN=PDLIM1 PE=1 SV=4" "0.000" "False" "83.504" "43" "11" "28" "11" "329" "36.0" "7.02" "88.53" "11" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595, Pf15936" "9124" "ENSG00000107438" "PDLIM1" "B2RBS6; hsa:9124; O00151; Q5VZH5; Q9BPZ9" "" "" "0" "0" "0.923" "0.997" "1.064" "0.959" "0.912" "0.958" "0.968" "0.947" "0.593" "1946.9" "1796.0" "1942.0" "2071.9" "1867.8" "1776.1" "1865.4" "1884.2" "1843.5" "1155.0" "" "" "" "" "" "" "" "" "" "" "1030.9" "995.8" "1112.2" "954.2" "1010.5" "987.9" "1097.9" "1028.5" "1034.2" "1155.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5299836175419688438" "False" "High" "IsMasterProtein" "P42166" "Lamina-associated polypeptide 2, isoform alpha OS=Homo sapiens OX=9606 GN=TMPO PE=1 SV=2" "0.000" "False" "82.679" "28" "16" "24" "16" "694" "75.4" "7.66" "77.72" "16" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03020, Pf08198, Pf11560" "7112" "ENSG00000120802" "TMPO" "P08918; P08919; P42166; Q14860; Q16295" "Envelope proteins and their potential roles in EDMD physiopathology; Overlap between signal transduction pathways contributing to LMNA laminopathies" "" "2" "0" "0.976" "1.012" "1.093" "1.048" "1.018" "1.472" "1.685" "1.616" "1.904" "1373.1" "1340.6" "1389.2" "1501.0" "1439.6" "1398.5" "2021.5" "2314.3" "2219.6" "2614.4" "" "" "" "" "" "" "" "" "" "" "727.1" "743.3" "795.6" "691.3" "778.9" "777.9" "1189.7" "1263.3" "1245.1" "2614.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7001879318500673012" "False" "High" "IsMasterProtein" "P11940" "Polyadenylate-binding protein 1 OS=Homo sapiens OX=9606 GN=PABPC1 PE=1 SV=2" "0.000" "False" "82.635" "32" "21" "50" "17" "636" "70.6" "9.50" "104.18" "21" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf00658" "26986" "ENSG00000070756" "PABPC1" "hsa:26986; P11940; Q15097; Q93004" "Translation factors; Endoderm differentiation; VEGFA-VEGFR2 signaling; Acute viral myocarditis" "AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of expression of SLITs and ROBOs; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "13" "3" "0.980" "0.940" "0.989" "0.971" "0.948" "0.836" "0.818" "0.878" "0.695" "3251.9" "3187.6" "3057.0" "3215.1" "3156.7" "3083.5" "2717.7" "2658.7" "2855.8" "2260.2" "" "" "" "" "" "" "" "" "" "" "1721.9" "1767.3" "1750.7" "1480.7" "1707.9" "1715.2" "1599.4" "1451.3" "1602.0" "2260.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5003304044033613110" "False" "High" "IsMasterProtein" "O43175" "D-3-phosphoglycerate dehydrogenase OS=Homo sapiens OX=9606 GN=PHGDH PE=1 SV=4" "0.000" "False" "82.623" "30" "13" "38" "13" "533" "56.6" "6.71" "111.25" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf00389, Pf02826, Pf19304" "26227" "ENSG00000092621" "PHGDH" "B2RD08; hsa:26227; O43175; Q5SZU3; Q9BQ01" "Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells" "Serine biosynthesis" "5" "0" "1.016" "1.010" "1.017" "1.042" "1.026" "1.018" "0.999" "0.971" "0.672" "2853.5" "2900.0" "2882.0" "2900.9" "2973.6" "2929.0" "2903.9" "2850.0" "2769.6" "1917.2" "" "" "" "" "" "" "" "" "" "" "1510.9" "1607.8" "1650.5" "1335.9" "1608.8" "1629.3" "1709.0" "1555.7" "1553.7" "1917.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8610404900026586522" "False" "High" "IsMasterProtein" "P27797" "Calreticulin OS=Homo sapiens OX=9606 GN=CALR PE=1 SV=1" "0.000" "False" "82.208" "37" "17" "29" "17" "417" "48.1" "4.44" "87.00" "17" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00262" "811" "ENSG00000179218" "CALR" "hsa:811; P27797; Q6IAT4; Q9UDG2" "Androgen receptor signaling pathway; Complement system; Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling; GDNF signaling; Calcium regulation in cardiac cells" "ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Scavenging by Class A Receptors; Assembly of Viral Components at the Budding Site; Scavenging by Class F Receptors; ATF6 (ATF6-alpha) activates chaperone genes; Calnexin/calreticulin cycle" "13" "0" "0.934" "1.000" "0.865" "0.889" "0.892" "0.876" "0.820" "0.966" "2.634" "3711.8" "3467.5" "3711.5" "3210.7" "3301.1" "3312.4" "3250.4" "3043.8" "3583.9" "9776.0" "" "" "" "" "" "" "" "" "" "" "1965.4" "1922.5" "2125.6" "1478.6" "1786.1" "1842.5" "1912.9" "1661.4" "2010.5" "9776.0" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2158743068394578481" "False" "High" "IsMasterProtein" "P29401" "Transketolase OS=Homo sapiens OX=9606 GN=TKT PE=1 SV=3" "0.000" "False" "81.959" "27" "16" "61" "16" "623" "67.8" "7.66" "182.28" "16" "other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf00456, Pf02779, Pf02780" "7086" "ENSG00000163931" "TKT" "A8K089; B4DE31; E7EPA7; hsa:7086; P29401; Q8TBA3; Q96HH3" "Pentose phosphate metabolism; VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer; Thiamine metabolic pathways" "NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate" "7" "0" "0.932" "1.016" "0.894" "0.929" "0.932" "1.057" "0.978" "0.912" "0.519" "6770.7" "6310.6" "6879.3" "6054.2" "6292.4" "6307.6" "7159.1" "6622.3" "6175.2" "3515.4" "" "" "" "" "" "" "" "" "" "" "3585.1" "3498.8" "3939.7" "2788.2" "3404.5" "3508.6" "4213.4" "3614.8" "3464.2" "3515.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4081821255654730279" "False" "High" "IsMasterProtein" "Q13618" "Cullin-3 OS=Homo sapiens OX=9606 GN=CUL3 PE=1 SV=2" "0.000" "False" "81.820" "21" "17" "18" "17" "768" "88.9" "8.48" "59.94" "17" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00888, Pf10557" "8452" "ENSG00000036257" "CUL3" "A8K536; B8ZZC3; hsa:8452; O75415; Q13618; Q569L3; Q9UBI8; Q9UET7" "Hereditary leiomyomatosis and renal cell carcinoma pathway; Hedgehog signaling pathway; NRF2-ARE regulation; 22q11.2 copy number variation syndrome; Head and neck squamous cell carcinoma; 1p36 copy number variation syndrome" "Potential therapeutics for SARS; Antigen processing: Ubiquitination & Proteasome degradation; Degradation of DVL; Hedgehog 'on' state; Regulation of RAS by GAPs; Neddylation; KEAP1-NFE2L2 pathway; RHOBTB3 ATPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "16" "0" "1.038" "0.985" "0.961" "0.987" "1.005" "1.009" "0.989" "0.947" "0.598" "1545.7" "1604.3" "1522.3" "1486.1" "1525.5" "1552.9" "1559.4" "1528.9" "1463.6" "925.0" "" "" "" "" "" "" "" "" "" "" "818.5" "889.5" "871.8" "684.4" "825.4" "863.8" "917.8" "834.5" "821.1" "925.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2726683976815450871" "False" "High" "IsMasterProtein" "P00338" "L-lactate dehydrogenase A chain OS=Homo sapiens OX=9606 GN=LDHA PE=1 SV=2" "0.000" "False" "81.581" "44" "16" "100" "14" "332" "36.7" "8.27" "265.54" "16" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "3939" "ENSG00000134333; ENSG00000288299" "LDHA" "B4DKQ2; B7Z5E3; D3DQY3; F8W819; hsa:3939; P00338; Q53G53; Q6IBM7; Q6ZNV1; Q9UDE8; Q9UDE9" "Cori cycle; HIF1A and PPARG regulation of glycolysis; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling; Amino acid metabolism; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; Hereditary leiomyomatosis and renal cell carcinoma pathway; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Orexin receptor pathway; CCL18 signaling pathway; Glucose metabolism in triple-negative breast cancer cells; Warburg effect modulated by deubiquitinating enzymes and their substrates; Lactate shuttle in glial cells; Glycolysis and gluconeogenesis; Macrophage-stimulating protein (MSP) signaling network map; Metabolic Epileptic Disorders" "Pyruvate metabolism" "20" "2" "1.056" "0.963" "1.009" "0.983" "1.058" "0.965" "1.003" "0.968" "0.576" "8691.4" "9181.7" "8374.0" "8766.8" "8541.9" "9194.2" "8384.2" "8715.4" "8411.3" "5003.1" "" "" "" "" "" "" "" "" "" "" "4602.1" "5090.6" "4795.8" "4037.4" "4621.5" "5114.3" "4934.3" "4757.3" "4718.5" "5003.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7054273267636823051" "False" "High" "IsMasterProtein" "Q08211" "ATP-dependent RNA helicase A OS=Homo sapiens OX=9606 GN=DHX9 PE=1 SV=4" "0.000" "False" "81.194" "17" "20" "30" "20" "1270" "140.9" "6.84" "82.74" "20" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00035, Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "1660" "ENSG00000135829" "DHX9" "B2RNV4; hsa:1660; Q05CI5; Q08211; Q12803; Q32Q22; Q5VY62; Q6PD69; Q99556" "MECP2 and associated Rett syndrome; mRNA processing" "mRNA Splicing - Major Pathway; PKR-mediated signaling; RIP-mediated NFkB activation via ZBP1; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "6" "0" "1.083" "1.029" "1.189" "1.043" "1.067" "1.235" "1.208" "1.206" "2.091" "1773.2" "1920.5" "1823.8" "2109.1" "1848.8" "1891.3" "2189.4" "2142.6" "2138.6" "3707.7" "" "" "" "" "" "" "" "" "" "" "938.9" "1064.8" "1044.5" "971.3" "1000.3" "1052.0" "1288.5" "1169.6" "1199.7" "3707.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2006906941817689569" "False" "High" "IsMasterProtein" "Q9Y520" "Protein PRRC2C OS=Homo sapiens OX=9606 GN=PRRC2C PE=1 SV=4" "0.000" "False" "81.006" "8" "22" "31" "21" "2896" "316.7" "9.13" "84.14" "22" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "" "Pf07001" "23215" "ENSG00000117523" "PRRC2C" "hsa:23215; Q05DM8; Q49A39; Q6PD54; Q9H2N2; Q9HA05; Q9NSM8; Q9NXL3; Q9UF29; Q9UPQ6; Q9Y520" "VEGFA-VEGFR2 signaling" "" "1" "1" "1.044" "1.058" "1.234" "1.056" "1.001" "1.132" "1.172" "1.132" "0.578" "2879.9" "3006.3" "3048.0" "3553.3" "3042.1" "2881.9" "3259.3" "3373.8" "3259.9" "1663.8" "" "" "" "" "" "" "" "" "" "" "1524.9" "1666.8" "1745.6" "1636.4" "1645.9" "1603.0" "1918.2" "1841.6" "1828.7" "1663.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7263541365096533312" "False" "High" "IsMasterProtein" "Q13435" "Splicing factor 3B subunit 2 OS=Homo sapiens OX=9606 GN=SF3B2 PE=1 SV=2" "0.000" "False" "80.169" "21" "18" "29" "18" "895" "100.2" "5.67" "88.90" "18" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf02037, Pf04037, Pf04046" "10992" "ENSG00000087365" "SF3B2" "A8K485; B4DT19; hsa:10992; Q13435; Q7L4T5; Q7Z627; Q969K1; Q96CM6; Q9BWD2" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "1.028" "1.013" "0.975" "0.972" "0.967" "0.998" "1.006" "1.032" "0.842" "3676.1" "3778.0" "3723.2" "3585.1" "3574.1" "3553.2" "3667.1" "3697.3" "3794.8" "3096.8" "" "" "" "" "" "" "" "" "" "" "1946.5" "2094.6" "2132.3" "1651.1" "1933.7" "1976.5" "2158.2" "2018.2" "2128.8" "3096.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2749950876556130584" "False" "High" "IsMasterProtein" "P0DMV9" "Heat shock 70 kDa protein 1B OS=Homo sapiens OX=9606 GN=HSPA1B PE=1 SV=1" "0.000" "False" "80.017" "28" "18" "36" "12" "641" "70.0" "5.66" "113.13" "18" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00012" "3303; 3304" "ENSG00000204388; ENSG00000212866; ENSG00000224501; ENSG00000231555; ENSG00000232804" "HSPA1B" "B4E3B6; hsa:3303; hsa:3304; P08107; P0DMV9; P19790; Q5JQI4; Q5SP17; Q9UQL9; Q9UQM0" "Apoptosis modulation and signaling; Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling; Measles virus infection" "Regulation of HSF1-mediated heat shock response; Neutrophil degranulation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; PKR-mediated signaling; Attenuation phase" "12" "0" "0.918" "1.077" "1.053" "1.052" "0.908" "0.854" "1.169" "0.926" "0.516" "2086.3" "1915.0" "2247.1" "2196.1" "2195.7" "1893.8" "1780.9" "2439.4" "1931.4" "1076.9" "" "" "" "" "" "" "" "" "" "" "1104.7" "1061.7" "1286.9" "1011.4" "1188.0" "1053.4" "1048.1" "1331.5" "1083.5" "1076.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2890284807861643792" "False" "High" "IsMasterProtein" "P22102" "Trifunctional purine biosynthetic protein adenosine-3 OS=Homo sapiens OX=9606 GN=GART PE=1 SV=1" "0.000" "False" "79.916" "18" "18" "33" "18" "1010" "107.7" "6.70" "87.31" "18" "other metabolic processes;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf00551, Pf00586, Pf01071, Pf02769, Pf02843, Pf02844" "2618" "ENSG00000159131; ENSG00000262473" "GART" "A8K945; A8KA32; D3DSF3; D3DSF4; hsa:2618; O14659; P22102; Q52M77" "Folate metabolism; One-carbon metabolism; Metabolic reprogramming in colon cancer" "Purine ribonucleoside monophosphate biosynthesis" "4" "0" "0.966" "0.969" "0.949" "0.987" "1.029" "0.900" "0.844" "0.887" "1.190" "3299.8" "3188.3" "3197.3" "3130.8" "3258.0" "3395.5" "2970.0" "2783.4" "2926.7" "3925.6" "" "" "" "" "" "" "" "" "" "" "1747.2" "1767.7" "1831.1" "1441.8" "1762.7" "1888.7" "1748.0" "1519.4" "1641.8" "3925.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6804108956499343623" "False" "High" "IsMasterProtein" "Q96G03" "Phosphopentomutase OS=Homo sapiens OX=9606 GN=PGM2 PE=1 SV=4" "0.000" "False" "79.896" "26" "18" "33" "17" "612" "68.2" "6.73" "95.91" "18" "other metabolic processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf02878, Pf02879, Pf02880" "55276" "ENSG00000169299" "PGM2" "B4E0G8; hsa:55276; Q53FP5; Q5QTR0; Q96G03; Q9H0P9; Q9NV22" "Clear cell renal cell carcinoma pathways; Glucuronidation" "Neutrophil degranulation; Pentose phosphate pathway" "4" "1" "0.976" "1.014" "0.967" "0.945" "0.980" "0.929" "1.033" "0.964" "0.502" "3929.6" "3834.3" "3986.3" "3800.1" "3714.4" "3852.2" "3648.9" "4057.5" "3788.0" "1972.8" "" "" "" "" "" "" "" "" "" "" "2080.7" "2125.9" "2283.0" "1750.1" "2009.6" "2142.7" "2147.5" "2214.8" "2125.0" "1972.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6707926075363841764" "False" "High" "IsMasterProtein" "Q99798" "Aconitate hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=ACO2 PE=1 SV=2" "0.000" "False" "79.740" "21" "15" "22" "15" "780" "85.4" "7.61" "69.39" "15" "other metabolic processes;stress response;developmental processes" "cytosol;mitochondrion" "other molecular function" "Pf00330, Pf00694" "50" "ENSG00000100412" "ACO2" "hsa:50; O75809; Q5JZ41; Q6FHX0; Q8TAQ6; Q99798" "Amino acid metabolism; Metabolic reprogramming in colon cancer; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle); Mitochondrial protein import; Mitochondrial protein degradation" "7" "0" "0.967" "0.958" "0.844" "0.903" "1.004" "0.843" "0.784" "0.904" "1.426" "1568.4" "1516.7" "1502.6" "1322.9" "1416.7" "1573.9" "1322.3" "1229.9" "1418.4" "2236.2" "" "" "" "" "" "" "" "" "" "" "830.4" "840.9" "860.5" "609.3" "766.5" "875.5" "778.2" "671.4" "795.7" "2236.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2050551167936510610" "False" "High" "IsMasterProtein" "Q01813" "ATP-dependent 6-phosphofructokinase, platelet type OS=Homo sapiens OX=9606 GN=PFKP PE=1 SV=2" "0.000" "False" "79.684" "26" "18" "30" "13" "784" "85.5" "7.55" "80.50" "18" "other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00365" "5214" "ENSG00000067057" "PFKP" "B3KS15; hsa:5214; Q01813; Q5VSR7; Q5VSR8" "Cori cycle; Clear cell renal cell carcinoma pathways; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis" "6" "5" "1.011" "0.969" "0.977" "0.902" "0.928" "0.917" "0.976" "0.992" "0.530" "2631.8" "2659.6" "2549.9" "2571.9" "2374.7" "2442.0" "2413.0" "2569.4" "2610.0" "1396.1" "" "" "" "" "" "" "" "" "" "" "1393.6" "1474.6" "1460.3" "1184.4" "1284.8" "1358.3" "1420.1" "1402.5" "1464.1" "1396.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "500586164942944818" "False" "High" "IsMasterProtein" "P67809" "Y-box-binding protein 1 OS=Homo sapiens OX=9606 GN=YBX1 PE=1 SV=3" "0.000" "False" "79.611" "43" "10" "38" "8" "324" "35.9" "9.88" "130.82" "10" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00313" "4904" "ENSG00000065978" "YBX1" "hsa:4904; P16990; P16991; P67809; Q14972; Q15325; Q5FVF0" "Brain-derived neurotrophic factor (BDNF) signaling pathway; MECP2 and associated Rett syndrome; mRNA processing; Sudden infant death syndrome (SIDS) susceptibility pathways" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Interferon gamma signaling; mRNA Splicing - Minor Pathway; Noncanonical activation of NOTCH3" "10" "2" "0.971" "1.010" "0.911" "0.777" "0.849" "0.816" "0.872" "0.837" "0.678" "3430.4" "3330.7" "3464.8" "3123.7" "2666.8" "2912.5" "2800.2" "2991.1" "2872.4" "2327.2" "" "" "" "" "" "" "" "" "" "" "1816.4" "1846.7" "1984.3" "1438.6" "1442.8" "1620.1" "1648.0" "1632.7" "1611.4" "2327.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3930283768056647308" "False" "High" "IsMasterProtein" "P31948" "Stress-induced-phosphoprotein 1 OS=Homo sapiens OX=9606 GN=STIP1 PE=1 SV=1" "0.000" "False" "79.310" "32" "21" "61" "21" "543" "62.6" "6.80" "155.32" "21" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00515, Pf13181, Pf17830" "10963" "ENSG00000168439" "STIP1" "B4DM70; F5H0T1; G3XAD8; hsa:10963; P31948; Q3ZCU9; Q5TZU9" "VEGFA-VEGFR2 signaling" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RND1 GTPase cycle" "3" "0" "0.952" "1.061" "0.983" "0.953" "0.928" "0.936" "1.046" "0.969" "0.712" "7107.7" "6766.5" "7544.4" "6988.3" "6775.6" "6593.8" "6655.6" "7431.3" "6889.3" "5057.4" "" "" "" "" "" "" "" "" "" "" "3763.5" "3751.5" "4320.7" "3218.3" "3665.9" "3667.8" "3917.0" "4056.4" "3864.7" "5057.4" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2100878916131084887" "False" "High" "IsMasterProtein" "P36871" "Phosphoglucomutase-1 OS=Homo sapiens OX=9606 GN=PGM1 PE=1 SV=3" "0.000" "False" "78.980" "34" "19" "32" "19" "562" "61.4" "6.76" "89.35" "19" "other metabolic processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf02878, Pf02879, Pf02880" "5236" "ENSG00000079739" "PGM1" "B2R5N9; B4DPV0; hsa:5236; P36871; Q16105; Q16106; Q5BKZ9; Q6NW22; Q86U74; Q96J40; Q9NTY4" "Ectoderm differentiation; Clear cell renal cell carcinoma pathways; Glycogen synthesis and degradation; Opioid receptor pathways; Disorders of galactose metabolism ; Disorders of fructose metabolism; UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "Neutrophil degranulation; Glycogen synthesis; Glycogen breakdown (glycogenolysis); Galactose catabolism; Defective PGM1 causes PGM1-CDG" "13" "0" "0.960" "0.967" "0.958" "1.044" "1.035" "1.033" "1.020" "0.982" "0.577" "4121.7" "3957.3" "3983.8" "3947.0" "4304.5" "4267.8" "4257.7" "4204.5" "4045.6" "2376.9" "" "" "" "" "" "" "" "" "" "" "2182.5" "2194.1" "2281.5" "1817.7" "2328.9" "2373.9" "2505.8" "2295.0" "2269.5" "2376.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4377208032786879179" "False" "High" "IsMasterProtein" "P51858" "Hepatoma-derived growth factor OS=Homo sapiens OX=9606 GN=HDGF PE=1 SV=1" "0.000" "False" "78.950" "64" "13" "46" "12" "240" "26.8" "4.73" "132.81" "13" "cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00855" "3068" "ENSG00000143321" "HDGF" "B3KU21; D3DVC9; P51858; Q5SZ07; Q5SZ08; Q5SZ09" "IL-18 signaling pathway" "XBP1(S) activates chaperone genes" "2" "0" "0.953" "1.044" "0.989" "0.975" "0.958" "1.012" "1.076" "1.066" "0.658" "3981.0" "3792.0" "4157.8" "3935.7" "3879.9" "3814.8" "4027.4" "4283.1" "4242.1" "2618.6" "" "" "" "" "" "" "" "" "" "" "2107.9" "2102.4" "2381.1" "1812.5" "2099.2" "2122.0" "2370.3" "2338.0" "2379.7" "2618.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9133260577685858014" "False" "High" "IsMasterProtein" "O00410" "Importin-5 OS=Homo sapiens OX=9606 GN=IPO5 PE=1 SV=4" "0.000" "False" "78.413" "18" "18" "29" "18" "1097" "123.6" "4.94" "85.79" "18" "transport;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02985, Pf18808, Pf18816, Pf18829" "3843" "ENSG00000065150" "IPO5" "B4DZA0; hsa:3843; O00410; O15257; Q5T578; Q86XC7" "" "vRNP Assembly" "1" "0" "1.092" "1.081" "1.049" "1.081" "1.143" "1.117" "1.132" "1.126" "0.810" "1418.1" "1549.2" "1532.4" "1487.2" "1533.0" "1620.6" "1584.4" "1605.4" "1596.3" "1148.3" "" "" "" "" "" "" "" "" "" "" "750.9" "858.9" "877.6" "684.9" "829.4" "901.4" "932.5" "876.3" "895.5" "1148.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-515522588376759980" "False" "High" "IsMasterProtein" "O60506" "Heterogeneous nuclear ribonucleoprotein Q OS=Homo sapiens OX=9606 GN=SYNCRIP PE=1 SV=2" "0.000" "False" "77.948" "24" "15" "42" "9" "623" "69.6" "8.59" "110.82" "15" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf18360" "10492" "ENSG00000135316" "SYNCRIP" "E1P501; E1P502; hsa:10492; O60506; Q53H05; Q5TCG2; Q5TCG3; Q8IW78; Q8N599; Q96LC1; Q96LC2; Q9Y583" "" "" "0" "6" "1.015" "0.959" "0.974" "1.001" "1.015" "0.952" "0.935" "0.975" "1.323" "2700.7" "2741.0" "2590.9" "2630.8" "2704.4" "2742.0" "2571.9" "2524.6" "2632.2" "3572.7" "" "" "" "" "" "" "" "" "" "" "1430.0" "1519.7" "1483.8" "1211.6" "1463.2" "1525.2" "1513.6" "1378.1" "1476.6" "3572.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "623640857413414358" "False" "High" "IsMasterProtein" "P61981" "14-3-3 protein gamma OS=Homo sapiens OX=9606 GN=YWHAG PE=1 SV=2" "0.000" "False" "77.661" "60" "14" "87" "8" "247" "28.3" "4.89" "187.18" "14" "stress response;signal transduction;other biological processes" "cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00244" "7532" "ENSG00000170027" "YWHAG" "hsa:7532; O70457; P35214; P61981; Q6FH52; Q9UDP2; Q9UN99" "Cell cycle; Prolactin signaling pathway; Myometrial relaxation and contraction pathways; Disruption of postsynaptic signaling by CNV; Calcium regulation in cardiac cells; 7q11.23 distal copy number variation; Sudden infant death syndrome (SIDS) susceptibility pathways" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria" "22" "1" "0.940" "0.953" "0.849" "0.791" "0.820" "0.797" "0.985" "0.958" "0.387" "3196.6" "3005.1" "3044.9" "2713.5" "2527.8" "2621.1" "2548.0" "3147.4" "3062.4" "1236.7" "" "" "" "" "" "" "" "" "" "" "1692.6" "1666.1" "1743.8" "1249.7" "1367.6" "1458.0" "1499.6" "1718.0" "1717.9" "1236.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7382790352375516909" "False" "High" "IsMasterProtein" "Q15393" "Splicing factor 3B subunit 3 OS=Homo sapiens OX=9606 GN=SF3B3 PE=1 SV=4" "0.000" "False" "77.362" "15" "18" "32" "18" "1217" "135.5" "5.26" "97.24" "18" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03178, Pf10433" "23450" "ENSG00000189091" "SF3B3" "hsa:23450; Q15393; Q6NTI8; Q96GC0; Q9BPY2; Q9UFX7; Q9UJ29" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "1.077" "1.015" "1.073" "1.066" "1.059" "1.095" "1.001" "1.096" "1.029" "1929.8" "2079.1" "1957.8" "2070.0" "2056.7" "2044.2" "2113.6" "1930.9" "2114.6" "1986.3" "" "" "" "" "" "" "" "" "" "" "1021.8" "1152.7" "1121.2" "953.3" "1112.7" "1137.1" "1243.9" "1054.0" "1186.2" "1986.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1414691960117410819" "False" "High" "IsMasterProtein" "P33991" "DNA replication licensing factor MCM4 OS=Homo sapiens OX=9606 GN=MCM4 PE=1 SV=5" "0.000" "False" "77.002" "20" "17" "32" "17" "863" "96.5" "6.74" "94.89" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855, Pf21128" "4173" "ENSG00000104738" "MCM4" "hsa:4173; P33991; Q8NEH1; Q99658" "Cell cycle; Gastric cancer network 1; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "12" "0" "0.971" "0.957" "0.881" "0.942" "0.960" "0.743" "0.748" "0.785" "0.948" "4299.6" "4175.8" "4114.6" "3788.2" "4051.4" "4126.7" "3195.0" "3214.0" "3373.9" "4077.0" "" "" "" "" "" "" "" "" "" "" "2276.6" "2315.2" "2356.4" "1744.6" "2192.0" "2295.4" "1880.3" "1754.4" "1892.7" "4077.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-160533791377362281" "False" "High" "IsMasterProtein" "P07195" "L-lactate dehydrogenase B chain OS=Homo sapiens OX=9606 GN=LDHB PE=1 SV=2" "0.000" "False" "75.819" "36" "12" "74" "10" "334" "36.6" "6.05" "196.18" "12" "other metabolic processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "3945" "ENSG00000111716" "LDHB" "hsa:3945; P07195" "Clear cell renal cell carcinoma pathways; CCL18 signaling pathway; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Pyruvate metabolism" "5" "0" "0.924" "1.000" "0.937" "1.007" "1.021" "0.992" "0.990" "0.956" "0.571" "4073.7" "3764.0" "4075.3" "3817.6" "4102.3" "4161.1" "4039.3" "4034.4" "3892.9" "2325.8" "" "" "" "" "" "" "" "" "" "" "2157.0" "2086.9" "2333.9" "1758.1" "2219.5" "2314.6" "2377.2" "2202.2" "2183.8" "2325.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2214005141303334461" "False" "High" "IsMasterProtein" "P12956" "X-ray repair cross-complementing protein 6 OS=Homo sapiens OX=9606 GN=XRCC6 PE=1 SV=2" "0.000" "False" "75.294" "27" "14" "35" "14" "609" "69.8" "6.64" "95.27" "14" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf02735, Pf03730, Pf03731" "2547" "ENSG00000196419" "XRCC6" "B1AHC8; hsa:2547; P12956; Q6FG89; Q9UCQ2; Q9UCQ3" "Non-homologous end joining; DNA repair pathways, full network; Primary ovarian insufficiency; HDAC6 interactions in the central nervous system" "Cytosolic sensors of pathogen-associated DNA ; Neutrophil degranulation; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation; IRF3-mediated induction of type I IFN" "9" "0" "1.055" "1.023" "1.185" "1.233" "1.186" "1.768" "1.733" "1.846" "2.246" "1746.9" "1843.3" "1786.8" "2070.8" "2153.4" "2071.7" "3089.1" "3026.5" "3225.2" "3923.0" "" "" "" "" "" "" "" "" "" "" "925.0" "1022.0" "1023.3" "953.7" "1165.1" "1152.4" "1818.1" "1652.0" "1809.3" "3923.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2586862151232699530" "False" "High" "IsMasterProtein" "P07237" "Protein disulfide-isomerase OS=Homo sapiens OX=9606 GN=P4HB PE=1 SV=3" "0.000" "False" "75.169" "32" "19" "39" "19" "508" "57.1" "4.87" "108.42" "19" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00085, Pf13848" "5034" "ENSG00000185624" "P4HB" "B2RDQ2; hsa:5034; P07237; P30037; P32079; Q15205; Q6LDE5" "VEGFA-VEGFR2 signaling; Type I collagen synthesis in the context of osteogenesis imperfecta" "Hedgehog ligand biogenesis; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Chylomicron assembly; VLDL assembly; LDL remodeling; Collagen biosynthesis and modifying enzymes; Detoxification of Reactive Oxygen Species; Insulin processing; Interleukin-12 signaling; Interleukin-23 signaling" "13" "0" "0.950" "0.984" "0.917" "0.943" "0.992" "0.989" "0.984" "1.001" "0.599" "5121.3" "4865.1" "5038.0" "4697.8" "4830.3" "5078.6" "5064.4" "5040.0" "5124.3" "3067.1" "" "" "" "" "" "" "" "" "" "" "2711.7" "2697.4" "2885.2" "2163.5" "2613.4" "2824.9" "2980.6" "2751.1" "2874.6" "3067.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2262993958771163174" "False" "High" "IsMasterProtein" "P40926" "Malate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=MDH2 PE=1 SV=3" "0.000" "False" "73.905" "46" "14" "47" "14" "338" "35.5" "8.68" "115.65" "14" "other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "4191" "ENSG00000146701" "MDH2" "A8K414; B2RE78; B4DE44; E9PDB2; O43682; P40926" "Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; 7q11.23 distal copy number variation; TCA cycle (aka Krebs or citric acid cycle)" "Gluconeogenesis; Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "10" "0" "1.008" "0.981" "0.988" "1.033" "0.975" "1.036" "0.947" "0.940" "0.518" "3108.1" "3134.0" "3048.8" "3072.2" "3209.4" "3031.8" "3219.4" "2944.4" "2922.9" "1608.7" "" "" "" "" "" "" "" "" "" "" "1645.8" "1737.6" "1746.1" "1414.9" "1736.4" "1686.4" "1894.7" "1607.2" "1639.7" "1608.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4636491781207187808" "False" "High" "IsMasterProtein" "P14868" "Aspartate--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=DARS1 PE=1 SV=2" "0.000" "False" "73.770" "36" "18" "34" "18" "501" "57.1" "6.55" "87.11" "18" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00152, Pf01336" "1615" "ENSG00000115866" "DARS1" "A8K3J2; D3DP77; hsa:1615; P14868; Q2TNI3; Q32Q69; Q53HV4; Q53YC5; Q68CR9; Q9BW52" "Alanine and aspartate metabolism" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "3" "0" "1.059" "0.987" "1.025" "1.048" "1.040" "0.945" "0.827" "0.912" "1.663" "2048.6" "2169.8" "2021.2" "2099.8" "2146.0" "2130.0" "1935.3" "1693.7" "1867.6" "3406.8" "" "" "" "" "" "" "" "" "" "" "1084.7" "1203.0" "1157.5" "967.0" "1161.0" "1184.8" "1139.0" "924.5" "1047.7" "3406.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4773459124454051332" "False" "High" "IsMasterProtein" "P49915" "GMP synthase [glutamine-hydrolyzing] OS=Homo sapiens OX=9606 GN=GMPS PE=1 SV=1" "0.000" "False" "73.567" "21" "15" "31" "15" "693" "76.7" "6.87" "93.42" "15" "other metabolic processes" "cytosol" "other molecular function" "Pf00117, Pf00958, Pf02540" "8833" "ENSG00000163655" "GMPS" "A8K639; B4DXV7; F8W720; hsa:8833; P49915" "" "Purine ribonucleoside monophosphate biosynthesis; Azathioprine ADME" "2" "0" "0.969" "0.916" "0.906" "1.015" "1.016" "0.905" "0.891" "0.905" "0.966" "2210.6" "2141.3" "2025.2" "2002.6" "2242.7" "2246.3" "2001.3" "1970.6" "2001.2" "2134.5" "" "" "" "" "" "" "" "" "" "" "1170.5" "1187.2" "1159.8" "922.2" "1213.4" "1249.5" "1177.9" "1075.7" "1122.6" "2134.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1039523901046503215" "False" "High" "IsMasterProtein" "P42704" "Leucine-rich PPR motif-containing protein, mitochondrial OS=Homo sapiens OX=9606 GN=LRPPRC PE=1 SV=3" "0.000" "False" "73.230" "14" "20" "28" "20" "1394" "157.8" "6.13" "73.02" "20" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf01535" "10128" "ENSG00000138095" "LRPPRC" "A0PJE3; A8K1V1; hsa:10128; P42704; Q53PC0; Q53QN7; Q6ZUD8; Q7Z7A6; Q96D84" "Ciliary landscape" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Mitochondrial RNA degradation" "5" "0" "1.023" "0.951" "1.169" "1.066" "1.062" "1.094" "0.251" "0.993" "14.198" "845.4" "864.6" "804.4" "988.5" "901.4" "897.7" "924.9" "212.3" "839.1" "12003.3" "" "" "" "" "" "" "" "" "" "" "447.7" "479.4" "460.7" "455.2" "487.7" "499.4" "544.3" "115.9" "470.7" "12003.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3936589147855356359" "False" "High" "IsMasterProtein" "P54886" "Delta-1-pyrroline-5-carboxylate synthase OS=Homo sapiens OX=9606 GN=ALDH18A1 PE=1 SV=2" "0.000" "False" "72.796" "20" "17" "29" "17" "795" "87.2" "7.12" "83.07" "17" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf00171, Pf00696" "5832" "ENSG00000059573" "ALDH18A1" "B2R5Q4; B7Z350; B7Z5X8; B7ZLP1; D3DR44; hsa:5832; O95952; P54886; Q3KQU2; Q5T566; Q5T567; Q9UM72" "Amino acid metabolism" "Mitochondrial protein degradation" "2" "0" "1.013" "0.970" "0.980" "0.960" "0.959" "0.824" "0.809" "0.818" "0.695" "2688.7" "2724.7" "2606.8" "2635.9" "2581.6" "2579.0" "2216.7" "2175.5" "2198.2" "1867.5" "" "" "" "" "" "" "" "" "" "" "1423.7" "1510.7" "1492.9" "1213.9" "1396.8" "1434.6" "1304.6" "1187.5" "1233.1" "1867.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7575182119282234217" "False" "High" "IsMasterProtein" "P18669" "Phosphoglycerate mutase 1 OS=Homo sapiens OX=9606 GN=PGAM1 PE=1 SV=2" "0.000" "False" "72.739" "41" "8" "49" "8" "254" "28.8" "7.18" "137.31" "8" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf00300" "5223" "ENSG00000171314" "PGAM1" "hsa:5223; P18669; Q9BWC0" "Cori cycle; Metabolic reprogramming in colon cancer; Warburg effect modulated by deubiquitinating enzymes and their substrates; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Neutrophil degranulation; Glycolysis; Gluconeogenesis" "8" "0" "0.938" "0.964" "0.897" "0.943" "0.958" "0.934" "0.970" "1.027" "0.512" "3104.4" "2911.8" "2992.6" "2786.0" "2927.3" "2972.5" "2898.5" "3010.0" "3187.5" "1588.3" "" "" "" "" "" "" "" "" "" "" "1643.8" "1614.4" "1713.9" "1283.0" "1583.8" "1653.5" "1705.8" "1643.0" "1788.1" "1588.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4347150339173577721" "False" "High" "IsMasterProtein" "Q92878" "DNA repair protein RAD50 OS=Homo sapiens OX=9606 GN=RAD50 PE=1 SV=1" "0.000" "False" "72.692" "17" "24" "29" "24" "1312" "153.8" "6.89" "75.09" "24" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04423, Pf13476, Pf13558" "10111" "ENSG00000113522" "RAD50" "B9EGF5; hsa:10111; O43254; Q6GMT7; Q6P5X3; Q92878; Q9UP86" "miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; Joubert syndrome; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; DNA damage response" "Sensing of DNA Double Strand Breaks; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Resolution of D-loop Structures through Holliday Junction Intermediates; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ)" "29" "0" "0.999" "0.997" "0.889" "0.910" "0.970" "0.821" "0.706" "0.878" "1.859" "3042.2" "3038.6" "3033.1" "2705.9" "2767.6" "2950.1" "2498.9" "2148.6" "2671.9" "5655.4" "" "" "" "" "" "" "" "" "" "" "1610.8" "1684.7" "1737.1" "1246.1" "1497.4" "1641.0" "1470.7" "1172.8" "1498.9" "5655.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4397536938893978881" "False" "High" "IsMasterProtein" "O43491" "Band 4.1-like protein 2 OS=Homo sapiens OX=9606 GN=EPB41L2 PE=1 SV=1" "0.000" "False" "71.977" "21" "21" "25" "18" "1005" "112.5" "5.44" "67.24" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380" "2037" "ENSG00000079819" "EPB41L2" "B4DHI8; E9PPD9; hsa:2037; O43491; Q5T4F0; Q68DV2" "Splicing factor NOVA regulated synaptic proteins" "Neurexins and neuroligins" "2" "3" "1.063" "1.033" "0.994" "1.006" "1.004" "0.948" "0.948" "0.991" "0.726" "3135.0" "3331.6" "3237.4" "3117.6" "3154.8" "3146.8" "2972.5" "2971.3" "3107.2" "2274.9" "" "" "" "" "" "" "" "" "" "" "1660.0" "1847.1" "1854.1" "1435.7" "1706.9" "1750.4" "1749.4" "1621.9" "1743.0" "2274.9" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6929162783006905550" "False" "High" "IsMasterProtein" "P20042" "Eukaryotic translation initiation factor 2 subunit 2 OS=Homo sapiens OX=9606 GN=EIF2S2 PE=1 SV=2" "0.000" "False" "71.901" "33" "12" "32" "12" "333" "38.4" "5.80" "97.74" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01873" "8894" "ENSG00000125977" "EIF2S2" "hsa:8894; P20042; Q9BVU0; Q9UJE4" "Translation factors; Brain-derived neurotrophic factor (BDNF) signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; Primary ovarian insufficiency" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; ABC-family proteins mediated transport; PKR-mediated signaling; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency; Cellular response to mitochondrial stress" "16" "0" "1.018" "1.029" "1.035" "1.005" "0.973" "0.965" "1.027" "0.967" "0.567" "3968.9" "4041.3" "4082.2" "4106.6" "3990.4" "3863.3" "3830.1" "4074.3" "3839.7" "2251.9" "" "" "" "" "" "" "" "" "" "" "2101.5" "2240.6" "2337.8" "1891.2" "2159.0" "2148.9" "2254.1" "2224.0" "2154.0" "2251.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7637669709604963095" "False" "High" "IsMasterProtein" "Q12888" "TP53-binding protein 1 OS=Homo sapiens OX=9606 GN=TP53BP1 PE=1 SV=2" "0.000" "False" "71.686" "10" "17" "21" "17" "1972" "213.4" "4.70" "58.60" "17" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09038, Pf18428" "7158" "ENSG00000067369" "TP53BP1" "F8VY86; hsa:7158; Q12888; Q2M1Z7; Q4LE46; Q5FWZ3; Q7Z3U4" "ATM signaling pathway; ATM signaling in development and disease" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of transcription factors; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "7" "0" "0.929" "1.011" "1.049" "1.078" "1.028" "1.295" "1.237" "1.310" "2.015" "1098.9" "1020.9" "1111.5" "1152.4" "1184.2" "1129.4" "1423.2" "1358.9" "1439.6" "2214.4" "" "" "" "" "" "" "" "" "" "" "581.9" "566.0" "636.6" "530.7" "640.7" "628.2" "837.6" "741.8" "807.6" "2214.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5868182849043771837" "False" "High" "IsMasterProtein" "Q15084" "Protein disulfide-isomerase A6 OS=Homo sapiens OX=9606 GN=PDIA6 PE=1 SV=1" "0.000" "False" "71.561" "24" "9" "30" "9" "440" "48.1" "5.08" "98.57" "9" "protein metabolism;other metabolic processes;stress response" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00085" "10130" "ENSG00000143870" "PDIA6" "B3KY95; B5MCQ5; B7Z254; B7Z4M8; F8WA83; hsa:10130; Q15084; Q53RC7; Q6ZSH5; Q99778" "Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; XBP1(S) activates chaperone genes" "5" "0" "0.980" "1.022" "0.897" "0.949" "0.988" "0.883" "1.020" "1.050" "0.629" "3449.7" "3382.3" "3524.3" "3095.5" "3274.1" "3408.5" "3047.0" "3518.0" "3620.6" "2170.1" "" "" "" "" "" "" "" "" "" "" "1826.6" "1875.2" "2018.4" "1425.6" "1771.4" "1896.0" "1793.2" "1920.3" "2031.1" "2170.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1304014562382960910" "False" "High" "IsMasterProtein" "O60216" "Double-strand-break repair protein rad21 homolog OS=Homo sapiens OX=9606 GN=RAD21 PE=1 SV=2" "0.000" "False" "71.400" "20" "11" "17" "11" "631" "71.6" "4.65" "55.57" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04824, Pf04825" "5885" "ENSG00000164754" "RAD21" "A8K0E0; hsa:5885; O60216; Q15001; Q99568" "Cell cycle; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; 10q22q23 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "13" "0" "1.094" "1.096" "0.984" "1.012" "1.011" "0.838" "1.003" "0.951" "0.805" "2018.4" "2208.3" "2211.4" "1985.4" "2041.9" "2041.5" "1691.2" "2025.2" "1920.3" "1625.6" "" "" "" "" "" "" "" "" "" "" "1068.7" "1224.3" "1266.4" "914.3" "1104.7" "1135.6" "995.3" "1105.5" "1077.3" "1625.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7738217365816998519" "False" "High" "IsMasterProtein" "P41250" "Glycine--tRNA ligase OS=Homo sapiens OX=9606 GN=GARS1 PE=1 SV=3" "0.000" "False" "71.364" "19" "14" "40" "14" "739" "83.1" "7.03" "108.60" "14" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "non-structural extracellular;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00458, Pf00587, Pf03129" "2617" "ENSG00000106105" "GARS1" "A0A090N8G0; B3KQA2; B4DIA0; hsa:2617; P41250; Q969Y1" "HDAC6 interactions in the central nervous system" "Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation" "3" "0" "0.956" "0.950" "0.931" "0.928" "0.971" "0.975" "0.971" "0.945" "0.478" "3285.4" "3140.1" "3120.1" "3058.0" "3050.1" "3190.7" "3202.7" "3188.8" "3104.6" "1568.9" "" "" "" "" "" "" "" "" "" "" "1739.6" "1741.0" "1786.9" "1408.3" "1650.2" "1774.8" "1884.9" "1740.6" "1741.6" "1568.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7448021442665095265" "False" "High" "IsMasterProtein" "O95347" "Structural maintenance of chromosomes protein 2 OS=Homo sapiens OX=9606 GN=SMC2 PE=1 SV=2" "0.000" "False" "71.072" "16" "21" "24" "21" "1197" "135.6" "8.43" "69.58" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "10592" "ENSG00000136824" "SMC2" "hsa:10592; O95347; Q6IEE0; Q9P1P2" "Retinoblastoma gene in cancer" "Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes" "3" "0" "1.072" "1.081" "1.092" "1.105" "1.106" "1.153" "0.496" "1.065" "7.118" "846.1" "907.2" "914.3" "924.1" "934.6" "936.1" "975.2" "419.4" "900.8" "6022.6" "" "" "" "" "" "" "" "" "" "" "448.0" "503.0" "523.6" "425.6" "505.7" "520.7" "573.9" "228.9" "505.3" "6022.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4445993330794884217" "False" "High" "IsMasterProtein" "P54577" "Tyrosine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=YARS1 PE=1 SV=4" "0.000" "False" "70.954" "37" "19" "30" "19" "528" "59.1" "7.05" "79.14" "19" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00579, Pf01588" "8565" "ENSG00000134684" "YARS1" "B3KWK4; D3DPQ4; hsa:8565; O43276; P54577; Q53EN1" "Nephrotic syndrome" "Cytosolic tRNA aminoacylation" "2" "0" "1.041" "0.979" "1.001" "1.008" "1.053" "0.900" "0.542" "0.921" "4.973" "1745.9" "1817.6" "1709.3" "1746.8" "1760.6" "1838.8" "1570.6" "945.5" "1608.3" "8682.5" "" "" "" "" "" "" "" "" "" "" "924.5" "1007.7" "978.9" "804.5" "952.6" "1022.8" "924.4" "516.1" "902.2" "8682.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5506725299494211183" "False" "High" "IsMasterProtein" "P25786" "Proteasome subunit alpha type-1 OS=Homo sapiens OX=9606 GN=PSMA1 PE=1 SV=1" "0.000" "False" "70.953" "55" "15" "40" "15" "263" "29.5" "6.61" "107.78" "15" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00227, Pf10584" "5682" "ENSG00000129084" "PSMA1" "A8K400; hsa:5682; P25786; Q53YE8; Q9BRV9" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "ER-Phagosome pathway; MAPK6/MAPK4 signaling; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "0.969" "0.983" "0.980" "0.970" "0.954" "1.049" "0.996" "0.913" "0.582" "3844.8" "3727.2" "3780.1" "3767.9" "3727.6" "3666.5" "4031.9" "3828.3" "3511.3" "2238.3" "" "" "" "" "" "" "" "" "" "" "2035.8" "2066.5" "2164.8" "1735.3" "2016.8" "2039.5" "2372.9" "2089.7" "1969.7" "2238.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2402053168044673171" "False" "High" "IsMasterProtein" "P06576" "ATP synthase subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1B PE=1 SV=3" "0.000" "False" "70.918" "30" "11" "24" "11" "529" "56.5" "5.40" "61.46" "11" "other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf00006, Pf02874" "506" "ENSG00000110955" "ATP5F1B" "A8K4X0; hsa:506; P06576; Q14283" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein import; Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "8" "0" "1.071" "0.995" "1.079" "1.095" "1.015" "1.091" "1.090" "1.008" "0.634" "978.8" "1048.5" "974.3" "1056.4" "1072.2" "993.5" "1067.8" "1066.8" "987.1" "620.8" "" "" "" "" "" "" "" "" "" "" "518.3" "581.3" "558.0" "486.5" "580.1" "552.6" "628.4" "582.3" "553.7" "620.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2847148615950550488" "False" "High" "IsMasterProtein" "P20700" "Lamin-B1 OS=Homo sapiens OX=9606 GN=LMNB1 PE=1 SV=2" "0.000" "False" "70.688" "30" "17" "28" "16" "586" "66.4" "5.16" "76.08" "17" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;nucleus" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00038, Pf00932" "4001" "ENSG00000113368" "LMNB1" "B2R6J6; hsa:4001; P20700; Q3SYN7; Q96EI6" "Fas ligand pathway and stress induction of heat shock proteins; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome" "RHOD GTPase cycle; RHOF GTPase cycle; Meiotic synapsis; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina; Breakdown of the nuclear lamina; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "14" "0" "1.026" "1.013" "1.291" "1.341" "1.270" "2.590" "2.937" "2.628" "0.804" "1644.5" "1687.6" "1665.8" "2123.2" "2205.5" "2088.5" "4259.9" "4829.0" "4321.2" "1322.7" "" "" "" "" "" "" "" "" "" "" "870.8" "935.6" "954.0" "977.8" "1193.3" "1161.7" "2507.1" "2635.9" "2424.1" "1322.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9142633453092605073" "False" "High" "IsMasterProtein" "Cont_P63103" "14-3-3 protein zeta/delta OS=Bos taurus OX=9913 GN=YWHAZ PE=1 SV=1" "0.000" "True" "69.538" "60" "13" "69" "8" "245" "27.7" "4.79" "163.72" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00244" "100030704; 100056060; 100127113; 100173609; 100411134; 100484483; 100596460; 100672224; 100727182; 100913480; 100977477; 101012101; 101021050; 101151099; 101331119; 101351914; 101384625; 101687663; 101721954; 101968271; 102019696; 102115184; 102175223; 102283808; 102742022; 102765675; 103004481; 103085559; 103121925; 103191924; 103261347; 103732836; 105005492; 105302907; 105476048; 105504209; 105542098; 105586543; 105719669; 105869900; 106847839; 107142838; 107512228; 109277999; 109382800; 109568481; 109697135; 287022; 472830; 475864; 709723; 7534; 780440" "ENSAMEG00000000328; ENSANAG00000027160; ENSBGRG00000009704; ENSBIXG00000019500; ENSBIXG00005001276; ENSBMSG00010017904; ENSBTAG00000000236; ENSCAFG00000000580; ENSCAFG00845028920; ENSCANG00000043345; ENSCATG00000024186; ENSCCAG00000037757; ENSCCNG00000015730; ENSCHIG00000020223; ENSCJAG00000015844; ENSCLAG00000004303; ENSCPOG00000040522; ENSCWAG00000015721; ENSDLEG00000002530; ENSEASG00005002806; ENSECAG00000021882; ENSFCAG00000037073; ENSG00000164924; ENSGGOG00000022133; ENSHGLG00100048437; ENSLAFG00000004944; ENSMFAG00000001740; ENSMICG00000034946; ENSMLEG00000033187; ENSMMMG00000016188; ENSMMNG00015011551; ENSMMSG00000002669; ENSMMUG00000006489; ENSMNEG00000041365; ENSMODG00000006158; ENSMPUG00000015158; ENSNGAG00000006289; ENSNLEG00000030006; ENSPANG00000010317; ENSPANG00000042694; ENSPEMG00000021714; ENSPPAG00000038734; ENSPPYG00000018791; ENSPSMG00000012736; ENSPSNG00000018640; ENSPTEG00000005862; ENSPTIG00000021410; ENSPTRG00000048115; ENSRFEG00010019368; ENSSBOG00000021820; ENSSDAG00000019504; ENSSHAG00000012671; ENSSSCG00000006062; ENSSSCG00015031811; ENSSSCG00025071491; ENSSSCG00035013965; ENSSSCG00045030109; ENSSSCG00050034502; ENSSSCG00055001784; ENSSSCG00060049326; ENSSSCG00070011887; ENSSSUG00005013206; ENSSTOG00000023864; ENSSVLG00005003330; ENSTSYG00000026493; ENSTTRG00000015906; ENSUAMG00000024432; ENSUMAG00000017568; ENSVURG00010007014; ENSVVUG00000013173" "LOC101351914; LOC111146608; Ywhaz; YWHAZ" "A0A096NQ71; A0A097C2Z1; A0A1D5QAJ7; A0A1S3ABR1; A0A1U7TL92; A0A250XWX3; A0A286XIL7; A0A2I2UD77; A0A2I3GBB0; A0A2J8PMJ1; A0A2J8UFH0; A0A2K5DCH7; A0A2K5KE38; A0A2K5L5H7; A0A2K5SHP3; A0A2K5TVK5; A0A2K5YR93; A0A2K6DL02; A0A2K6SRG4; A0A2R9BQD0; A0A2U3W322; A0A2U3YQG6; A0A2U4AHZ7; A0A2Y9GYG0; A0A2Y9JAB1; A0A2Y9PAR8; A0A2Y9QK13; A0A340XXA5; A0A344MNR9; A0A383ZE89; A0A384BYY2; A0A3Q7NYD6; A0A3Q7S418; A0A452SHE3; A0A480PLY3; A0A4W2CSD8; A0A4X1TV95; A0A4X2KB08; A0A518J2H6; A0A5E4AK25; A0A671FTZ7; A0A673UG86; A0A6B0SHT8; A0A6D2XVW1; A0A6J0W154; A0A6J1ZUX6; A0A6J2B9D9; A0A6J2NBP1; A0A6J3FPA9; A0A6P3J5F7; A0A6P3R2S0; A0A6P5CUI6; A0A6P5ISH5; A0A6P6HS74; A0A7J7TL19; A0A7J7VNU9; A0A7J8C4Y7; A0A7J8DUV8; A0A7N4P7P6; A0A7N5KS25; A0A8B6ZD59; A0A8B7G6A9; A0A8B7RAL2; A0A8B8VLP3; A0A8B9X1D7; A0A8C2UZS6; A0A8C3WSB1; A0A8C4KZ72; A0A8C5ZR25; A0A8C6BH51; A0A8C6CXQ8; A0A8C6QKN2; A0A8C8U9V5; A0A8C8ZIR5; A0A8C9E7Q2; A0A8C9GP54; A0A8C9KQT4; A0A8C9Q7D7; A0A8D2CLR5; A0A8I3Q1P7; A0A8J8XBY4; A0A8J8Y9Q2; A0A8P0S6K0; A0A9V1GJ83; A0A9X9LZ30; A8K1N0; aju:106980045; aml:100484483; B7Z465; bacu:103004481; bbis:105005492; biu:109568481; bom:102283808; bta:287022; cang:105504209; caty:105586543; ccan:109697135; cfa:475864; chx:102175223; cjc:100411134; cpoc:100727182; csyr:103261347; D0PNI1; dle:111180376; elk:111146608; F6XEB4; F7BS95; F7EFF6; F7G9D2; F7HBD4; fca:100127113; G3RS45; G3SV87; G5AP01; G7MZV8; G7PCF6; ggo:101151099; hai:109382800; hgl:101721954; hsa:7534; I3N206; K7DDM2; L5M3G8; lav:100672224; lve:103085559; lww:102742022; M3WVC7; M3YUN9; mcc:709723; mcf:102115184; mdo:100030704; mleu:105542098; mmur:105869900; mni:105476048; mpuf:101687663; myd:102765675; ngi:103732836; nle:100596460; nsu:110579154; oro:101384625; P29213; P29312; P63103; P63104; panu:101012101; panu:101021050; pcoo:112859599; pcw:110196285; pdic:114514896; pon:100173609; pps:100977477; ptg:102966103; ptr:472830; pvp:105302907; Q32P43; Q3ZCF9; Q5R651; Q5XJ08; Q6GPI2; Q6IN74; Q6NUR9; Q6P3U9; Q86V33; ray:107512228; sbq:101047958; shr:100913480; tmu:101351914; U3E3R3; umr:103661509; vvp:112916971; zca:113910054" "Calcium regulation in cardiac cell; Cell cycle; Cell cycle; Prolactin signaling pathway; Pathogenic Escherichia coli infection; Myometrial relaxation and contraction pathways; SIDS susceptibility pathways; Pathogenic Escherichia coli infection; Myometrial relaxation and contraction pathways; Hepatitis B infection; GDNF signaling; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways; Calcium regulation in cardiac cells" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Negative regulation of NOTCH4 signaling; TP53 Regulates Metabolic Genes; Interleukin-3, Interleukin-5 and GM-CSF signaling; Activation of BAD and translocation to mitochondria ; Rap1 signalling; RHO GTPases activate PKNs; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Regulation of localization of FOXO transcription factors; Deactivation of the beta-catenin transactivating complex; KSRP (KHSRP) binds and destabilizes mRNA; GP1b-IX-V activation signalling; NOTCH4 Activation and Transmission of Signal to the Nucleus; Regulation of localization of FOXO transcription factors; Deactivation of the beta-catenin transactivating complex; Interleukin-3, Interleukin-5 and GM-CSF signaling; TP53 Regulates Metabolic Genes; NOTCH4 Activation and Transmission of Signal to the Nucleus; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Rap1 signalling; KSRP (KHSRP) binds and destabilizes mRNA; GP1b-IX-V activation signalling; Activation of BAD and translocation to mitochondria" "40" "1" "1.029" "1.074" "0.929" "0.992" "1.033" "1.056" "1.127" "1.169" "0.623" "2052.7" "2111.6" "2204.9" "1907.0" "2035.4" "2120.3" "2167.8" "2314.1" "2400.4" "1278.1" "" "" "" "" "" "" "" "" "" "" "1086.9" "1170.7" "1262.8" "878.2" "1101.2" "1179.4" "1275.8" "1263.2" "1346.5" "1278.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7017874985935534894" "False" "High" "IsMasterProtein" "P18206" "Vinculin OS=Homo sapiens OX=9606 GN=VCL PE=1 SV=4" "0.000" "False" "69.271" "19" "22" "29" "22" "1134" "123.7" "5.66" "69.96" "22" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf01044" "7414" "ENSG00000035403" "VCL" "hsa:7414; P18206; Q16450; Q5SWX2; Q7Z3B8; Q8IXU7" "Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; VEGFA-VEGFR2 signaling; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Melanoma; Regulation of actin cytoskeleton" "Platelet degranulation ; Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; Signaling by ALK fusions and activated point mutants; Smooth Muscle Contraction; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "18" "0" "1.026" "1.007" "1.058" "1.047" "1.004" "1.051" "1.026" "0.996" "0.627" "2223.6" "2282.3" "2239.0" "2352.4" "2328.8" "2232.3" "2337.1" "2281.7" "2214.3" "1394.4" "" "" "" "" "" "" "" "" "" "" "1177.4" "1265.4" "1282.3" "1083.4" "1260.0" "1241.7" "1375.4" "1245.5" "1242.2" "1394.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5909350322516910922" "False" "High" "IsMasterProtein" "P40222" "Alpha-taxilin OS=Homo sapiens OX=9606 GN=TXLNA PE=1 SV=3" "0.000" "False" "69.255" "30" "15" "22" "15" "546" "61.9" "6.52" "73.30" "15" "transport;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf09728" "200081" "ENSG00000084652" "TXLNA" "D3DPP6; hsa:200081; P40222; Q5TFJ6; Q66K62; Q86T54; Q86T85; Q86T86; Q86Y86; Q86YW3; Q8N2Y3" "" "Other interleukin signaling" "1" "0" "1.029" "1.031" "1.040" "0.967" "0.952" "1.015" "1.018" "1.009" "0.733" "1204.8" "1239.5" "1242.4" "1253.2" "1165.5" "1147.2" "1223.4" "1227.1" "1216.0" "883.3" "" "" "" "" "" "" "" "" "" "" "638.0" "687.2" "711.5" "577.2" "630.6" "638.1" "720.0" "669.8" "682.1" "883.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4155367153969888648" "False" "High" "IsMasterProtein" "Cont_P13645" "Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6" "0.000" "True" "68.427" "26" "14" "26" "11" "584" "58.8" "5.21" "72.74" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;other molecular function" "Pf00038" "3858" "ENSG00000186395" "KRT10" "hsa:3858; P13645; Q14664; Q8N175" "" "Formation of the cornified envelope" "2" "2" "0.697" "0.143" "0.153" "0.236" "0.270" "0.599" "0.491" "0.107" "0.214" "4437.0" "3093.9" "635.0" "678.3" "1048.1" "1198.4" "2658.2" "2178.5" "474.7" "951.6" "" "" "" "" "" "" "" "" "" "" "2349.4" "1715.3" "363.6" "312.4" "567.1" "666.6" "1564.4" "1189.1" "266.3" "951.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4912222715256496910" "False" "High" "IsMasterProtein" "O43390" "Heterogeneous nuclear ribonucleoprotein R OS=Homo sapiens OX=9606 GN=HNRNPR PE=1 SV=1" "0.000" "False" "68.257" "23" "14" "28" "8" "633" "70.9" "8.13" "78.92" "14" "RNA metabolism OR transcription;other metabolic processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf18360" "10236" "ENSG00000125944; ENSG00000282958" "HNRNPR" "hsa:10236; O43390; Q2L7G6; Q5TEH1; Q9BV64; S4R3J4" "mRNA processing" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "3" "0" "1.064" "0.918" "1.110" "1.091" "1.030" "1.198" "0.690" "1.103" "6.387" "673.4" "716.3" "618.4" "747.7" "734.7" "693.4" "806.9" "464.5" "742.8" "4301.3" "" "" "" "" "" "" "" "" "" "" "356.6" "397.2" "354.2" "344.3" "397.5" "385.7" "474.9" "253.6" "416.7" "4301.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2868702294912813046" "False" "High" "IsMasterProtein" "P60174" "Triosephosphate isomerase OS=Homo sapiens OX=9606 GN=TPI1 PE=1 SV=4" "0.000" "False" "68.088" "50" "12" "37" "12" "249" "26.7" "6.90" "130.28" "12" "other metabolic processes" "cytosol" "other molecular function" "Pf00121" "7167" "ENSG00000111669" "TPI1" "B7Z5D8; D3DUS9; hsa:7167; P00938; P60174; Q6FHP9; Q6IS07; Q8WWD0; Q96AG5" "Fatty acid beta-oxidation; Cori cycle; HIF1A and PPARG regulation of glycolysis; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Disorders of fructose metabolism; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Gluconeogenesis" "10" "0" "0.955" "0.951" "0.929" "0.975" "0.979" "0.933" "0.977" "0.923" "0.537" "2952.7" "2819.2" "2806.6" "2742.5" "2878.0" "2890.6" "2755.6" "2884.9" "2725.6" "1585.7" "" "" "" "" "" "" "" "" "" "" "1563.4" "1563.1" "1607.3" "1263.0" "1557.1" "1607.9" "1621.7" "1574.8" "1529.0" "1585.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7460100142715479081" "False" "High" "IsMasterProtein" "P09960" "Leukotriene A-4 hydrolase OS=Homo sapiens OX=9606 GN=LTA4H PE=1 SV=2" "0.000" "False" "68.071" "29" "16" "32" "16" "611" "69.2" "6.18" "86.94" "16" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01433, Pf09127, Pf17900" "4048" "ENSG00000111144" "LTA4H" "B4DNQ9; F8VV40; hsa:4048; P09960; Q6IAT6; Q9UCT7" "Eicosanoid metabolism via lipooxygenases (LOX); Prostaglandin and leukotriene metabolism in senescence ; Leukotriene metabolic pathway; Prostaglandin and leukotriene metabolism in senescence ; Omega-6-fatty acids in senescence" "Neutrophil degranulation; Biosynthesis of protectins; Synthesis of Leukotrienes (LT) and Eoxins (EX); Biosynthesis of D-series resolvins; Biosynthesis of E-series 18(S)-resolvins; Biosynthesis of aspirin-triggered D-series resolvins; Biosynthesis of E-series 18(R)-resolvins" "12" "0" "1.031" "1.017" "1.051" "1.057" "1.061" "1.047" "1.069" "1.001" "0.825" "2181.0" "2247.6" "2218.2" "2292.0" "2304.3" "2314.8" "2282.9" "2331.8" "2182.4" "1800.0" "" "" "" "" "" "" "" "" "" "" "1154.8" "1246.2" "1270.3" "1055.5" "1246.7" "1287.6" "1343.5" "1272.8" "1224.3" "1800.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4267649636453152821" "False" "High" "IsMasterProtein" "P16949" "Stathmin OS=Homo sapiens OX=9606 GN=STMN1 PE=1 SV=3" "0.000" "False" "67.983" "64" "11" "104" "11" "149" "17.3" "5.97" "240.61" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00836" "3925" "ENSG00000117632" "STMN1" "A2A2D1; B2R4E7; B7Z8N4; D3DPJ5; hsa:3925; P16949" "Microtubule cytoskeleton regulation; Retinoblastoma gene in cancer; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; EGF/EGFR signaling pathway; IL-18 signaling pathway" "Nuclear signaling by ERBB4" "7" "0" "0.894" "0.989" "0.954" "0.931" "0.936" "0.913" "0.929" "0.889" "0.489" "4821.4" "4312.3" "4767.8" "4601.2" "4488.8" "4511.7" "4403.0" "4480.3" "4287.5" "2356.1" "" "" "" "" "" "" "" "" "" "" "2552.9" "2390.9" "2730.5" "2119.0" "2428.6" "2509.6" "2591.3" "2445.6" "2405.2" "2356.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4862457629609710254" "False" "High" "IsMasterProtein" "Q5SW79" "Centrosomal protein of 170 kDa OS=Homo sapiens OX=9606 GN=CEP170 PE=1 SV=1" "0.000" "False" "67.931" "12" "18" "20" "16" "1584" "175.2" "7.11" "57.24" "18" "" "cytosol;cytoskeleton;other cell component" "" "Pf00498, Pf15308" "9859" "ENSG00000143702; ENSG00000276725" "CEP170" "hsa:9859; O75058; Q5SW77; Q5SW78; Q5SW79; Q7LGA9; Q86W31; Q9UQ08; Q9UQ09" "Ciliary landscape" "" "1" "1" "0.961" "0.946" "1.069" "1.049" "0.994" "1.269" "1.288" "1.375" "1.085" "1851.2" "1779.7" "1751.0" "1979.8" "1942.4" "1840.3" "2349.9" "2384.6" "2544.5" "2008.1" "" "" "" "" "" "" "" "" "" "" "980.2" "986.7" "1002.8" "911.8" "1050.9" "1023.7" "1383.0" "1301.6" "1427.4" "2008.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1968544072233028588" "False" "High" "IsMasterProtein" "P23246" "Splicing factor, proline- and glutamine-rich OS=Homo sapiens OX=9606 GN=SFPQ PE=1 SV=2" "0.000" "False" "67.882" "26" "17" "28" "16" "707" "76.1" "9.44" "63.28" "17" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08075" "6421" "ENSG00000116560" "SFPQ" "hsa:6421; P23246; P30808; Q5SZ71" "mRNA processing; Type 2 papillary renal cell carcinoma" "Suppression of apoptosis; PTK6 Regulates Proteins Involved in RNA Processing" "4" "1" "0.979" "0.995" "1.022" "1.079" "1.107" "1.066" "0.726" "1.071" "4.967" "1449.5" "1419.6" "1442.8" "1481.6" "1564.6" "1604.8" "1545.4" "1052.7" "1552.8" "7199.3" "" "" "" "" "" "" "" "" "" "" "767.5" "787.1" "826.3" "682.3" "846.5" "892.6" "909.5" "574.6" "871.1" "7199.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8790717896449630852" "False" "High" "IsMasterProtein" "Q9UPT8" "Zinc finger CCCH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=ZC3H4 PE=1 SV=3" "0.000" "False" "67.825" "14" "13" "19" "12" "1303" "140.2" "6.27" "59.49" "13" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608, Pf18044" "23211" "ENSG00000130749" "ZC3H4" "hsa:23211; Q9UPT8; Q9Y420" "" "" "0" "0" "1.009" "1.050" "1.119" "1.128" "1.007" "1.557" "1.709" "1.674" "0.775" "1268.8" "1280.3" "1332.6" "1420.2" "1431.7" "1277.9" "1975.4" "2167.8" "2124.3" "982.9" "" "" "" "" "" "" "" "" "" "" "671.8" "709.9" "763.2" "654.1" "774.6" "710.8" "1162.6" "1183.3" "1191.7" "982.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-410325427073227732" "False" "High" "IsMasterProtein" "Cont_P68103" "Elongation factor 1-alpha 1 OS=Bos taurus OX=9913 GN=EEF1A1 PE=1 SV=1" "0.000" "True" "67.687" "30" "16" "75" "16" "462" "50.1" "9.01" "220.16" "16" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "100009189; 100137407; 100173928; 100415334; 100455760; 100583632; 100720380; 100860780; 100894850; 100978974; 101016039; 101102857; 101114018; 101120236; 101143481; 101427577; 101925273; 102283704; 102540473; 102729396; 102952660; 102986013; 103243896; 104657006; 104668174; 104669279; 104675330; 105064770; 105589208; 108529199; 108538073; 109248229; 109261840; 109563706; 1915; 282220; 403506; 493922; 494136; 574059; 716010" "ENSBGRG00000009070; ENSBIXG00000015018; ENSBIXG00005015547; ENSBMUG00000019814; ENSBTAG00000014534; ENSCABG00000013336; ENSCAFG00000002656; ENSCAFG00000054475; ENSCAFG00000056088; ENSCAFG00000057183; ENSCAFG00030004385; ENSCAFG00030013393; ENSCAFG00030013497; ENSCAFG00030026219; ENSCAFG00040018088; ENSCAFG00845012150; ENSCATG00000039727; ENSCCAG00000033087; ENSCHIG00000010087; ENSCJAG00000083200; ENSCPOG00000004067; ENSCSAG00000014041; ENSCWAG00000008166; ENSEASG00005004328; ENSEASG00005023174; ENSFCAG00000030977; ENSG00000156508; ENSGGOG00000025675; ENSLCNG00005010676; ENSMMUG00000004852; ENSNLEG00000035164; ENSOARG00000006149; ENSOARG00000007762; ENSOARG00000011616; ENSOCUG00000008481; ENSPANG00000006932; ENSPCTG00005022294; ENSPLOG00000016117; ENSPPAG00000038736; ENSPPYG00000016777; ENSPTEG00000025546; ENSPTIG00000007871; ENSPTRG00000018347; ENSRBIG00000028957; ENSRROG00000044652; ENSSSCG00005007871; ENSSSCG00015021824; ENSSSCG00035049336; ENSSSCG00060027448; ENSSSCG00065043427; ENSSSCG00070013256; ENSTGEG00000013204" "EEF1A; Eef1a1; EEF1A1; LOC102523342; LOC102540473; LOC105064770; LOC105879067; LOC111096123; LOC111152497; LOC112630422; LOC118356941; RABEFLA2" "A0A096NSJ4; A0A0D9RNJ1; A0A2I3HHP9; A0A2J8PVY3; A0A2J8RYS8; A0A2K5N7Z5; A0A2K5RPQ1; A0A2K6KG30; A0A2K6RQ54; A0A2R9BYN3; A0A2U3XB66; A0A2Y9F799; A0A2Y9HH84; A0A2Y9K0L0; A0A452E2H7; A0A485PKI5; A0A4W2G2H2; A0A4X1U102; A0A5N4BZH2; A0A663DJ63; A0A667H9L1; A0A6I9I937; A0A6J0YU90; A0A6J1ZA85; A0A6J3HMT0; A0A6P5CAS0; A0A6P6HZ37; A0A6P7EC07; A0A6P7EG13; A0A6P9FBB6; A0A811YU57; A0A8B7HCC5; A0A8B8RGI1; A0A8B9X6G1; A0A8C0H2M0; A0A8C0NJT4; A0A8C3W2U9; A0A8C4L5X9; A0A8C8XSK7; A0A8C9HVZ6; A0A8C9JCC1; A0A8D0I6I6; A0A8D2F6F8; A0A8D8FTM6; A0A8H2XW05; A0A8I3VX86; A0A8M1H472; A0A8U0UW05; A0A9L0JZA8; A0A9V1E3R7; A0A9W3GP67; A5PK01; A9X189; aju:106980206; B1MTF5; B7NZC3; biu:109563706; bom:102283704; bta:282220; C3PT41; caty:105589208; cfa:403506; cfr:102523342; chx:100860780; cjc:100415334; cjc:100894850; cpoc:100720380; csab:103243896; dnm:101427577; elk:111152497; F1RQG6; F2Z4P4; F6VFC8; F7AW94; fca:493922; G2HFA2; G3S518; ggo:101143481; H0V2B3; hsa:1915; L8I7U3; lww:102729396; mcc:716010; mcf:101925273; mmur:105879067; mpuf:101672541; nle:100583632; nsu:110583033; oas:101102857; oas:101114018; oas:101120236; ocu:100009189; P04719; P04720; P68103; P68104; P68105; panu:100137407; panu:101016039; pcad:102986013; pcoo:112862036; pon:100173928; pon:100455760; pps:100978974; ptg:102952660; ptr:494136; Q0PY11; Q2KJJ3; Q4R5K0; Q5NVF3; Q5R1X2; Q5R4R8; Q66RN5; Q6IPS9; Q6IQ15; rbb:108529199; rbb:108538073; rro:104657006; rro:104668174; rro:104669279; rro:104675330; ssc:574059; umr:103657393; vpc:102540473; W5PD15; zca:118356820; zca:118356941" "Translation factors; EGFR1 signaling pathway; Fragile X syndrome; 2q37 copy number variation syndrome; EGFR1 signaling pathway" "Neutrophil degranulation; Protein methylation; HSF1 activation; Eukaryotic Translation Elongation; Neutrophil degranulation; Neutrophil degranulation; Protein methylation; Eukaryotic Translation Elongation; HSF1 activation; Chaperone Mediated Autophagy; Protein methylation; HSF1 activation; Peptide chain elongation; SARS-CoV-1 modulates host translation machinery" "20" "0" "1.014" "1.012" "0.978" "0.951" "0.934" "0.800" "0.891" "0.812" "0.679" "7675.3" "7781.0" "7768.5" "7505.1" "7298.1" "7168.2" "6139.8" "6837.5" "6230.0" "5209.8" "" "" "" "" "" "" "" "" "" "" "4064.0" "4314.0" "4449.0" "3456.3" "3948.5" "3987.3" "3613.5" "3732.3" "3494.9" "5209.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2651873567954206530" "False" "High" "IsMasterProtein" "Q9P2J5" "Leucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=LARS1 PE=1 SV=2" "0.000" "False" "67.604" "13" "16" "27" "16" "1176" "134.4" "7.30" "78.20" "16" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00133, Pf08264" "51520" "ENSG00000133706" "LARS1" "A2RRR4; A7E266; B4DJ10; hsa:51520; Q2TU79; Q9NSE1; Q9P2J5" "" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "2" "0" "1.070" "1.005" "1.048" "1.108" "1.104" "0.971" "0.436" "0.927" "6.385" "1213.1" "1298.2" "1218.7" "1271.4" "1344.5" "1339.5" "1177.7" "529.3" "1123.9" "7745.3" "" "" "" "" "" "" "" "" "" "" "642.3" "719.8" "697.9" "585.5" "727.4" "745.1" "693.1" "288.9" "630.5" "7745.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1534536598926653536" "False" "High" "IsMasterProtein" "P05198" "Eukaryotic translation initiation factor 2 subunit 1 OS=Homo sapiens OX=9606 GN=EIF2S1 PE=1 SV=3" "0.000" "False" "67.575" "46" "13" "32" "13" "315" "36.1" "5.08" "93.74" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf00575, Pf07541" "1965" "ENSG00000134001" "EIF2S1" "hsa:1965; P05198" "Translation factors; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebola virus infection in host; Nonalcoholic fatty liver disease; Measles virus infection; Unfolded protein response; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; Alzheimer's disease" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; PKR-mediated signaling; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency; Cellular response to mitochondrial stress" "21" "0" "0.994" "0.998" "0.964" "1.030" "1.038" "0.986" "0.998" "1.044" "0.698" "3226.5" "3207.9" "3218.8" "3109.9" "3322.9" "3350.5" "3182.4" "3220.5" "3367.4" "2251.8" "" "" "" "" "" "" "" "" "" "" "1708.4" "1778.5" "1843.4" "1432.2" "1797.8" "1863.7" "1872.9" "1757.9" "1889.0" "2251.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7129667850847229200" "False" "High" "IsMasterProtein" "P52209" "6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens OX=9606 GN=PGD PE=1 SV=3" "0.000" "False" "67.452" "22" "12" "42" "12" "483" "53.1" "7.23" "127.24" "12" "other metabolic processes" "cytosol" "other molecular function" "Pf00393, Pf03446" "5226" "ENSG00000142657" "PGD" "A8K2Y9; B4DQJ8; hsa:5226; P52209; Q9BWD8" "Pentose phosphate metabolism; Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer" "NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway" "7" "0" "0.966" "0.940" "0.995" "1.010" "0.967" "1.031" "0.982" "0.916" "0.585" "4537.0" "4383.9" "4263.4" "4513.1" "4584.5" "4387.2" "4677.6" "4456.6" "4155.4" "2653.9" "" "" "" "" "" "" "" "" "" "" "2402.3" "2430.6" "2441.6" "2078.4" "2480.4" "2440.3" "2752.9" "2432.6" "2331.1" "2653.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2064522308959827201" "False" "High" "IsMasterProtein" "Q92841" "Probable ATP-dependent RNA helicase DDX17 OS=Homo sapiens OX=9606 GN=DDX17 PE=1 SV=2" "0.000" "False" "67.451" "22" "16" "23" "11" "729" "80.2" "8.27" "51.87" "16" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "10521" "ENSG00000100201" "DDX17" "B1AHM0; H3BLZ8; hsa:10521; Q69YT1; Q6ICD6; Q92841" "Novel intracellular components of RIG-I-like receptor pathway" "SUMOylation of transcription cofactors" "2" "3" "1.025" "1.000" "1.102" "1.115" "1.106" "1.034" "0.858" "1.045" "3.337" "747.3" "765.7" "747.3" "823.3" "833.3" "826.3" "772.7" "641.0" "780.8" "2494.0" "" "" "" "" "" "" "" "" "" "" "395.7" "424.5" "428.0" "379.1" "450.8" "459.6" "454.8" "349.9" "438.0" "2494.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7479442399663165637" "False" "High" "IsMasterProtein" "Cont_P02769" "Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4" "0.000" "True" "67.289" "26" "17" "32" "16" "607" "69.2" "6.18" "81.40" "17" "stress response;other biological processes" "non-structural extracellular;other cell component" "nucleic acid binding activity;other molecular function" "Pf00273" "280717" "" "ALB" "A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2" "" "" "0" "1" "0.987" "0.992" "1.118" "1.391" "1.396" "1.181" "1.361" "1.436" "0.673" "2987.7" "2949.1" "2964.1" "3341.1" "4154.6" "4172.0" "3529.6" "4066.5" "4289.1" "2012.0" "" "" "" "" "" "" "" "" "" "" "1582.0" "1635.1" "1697.6" "1538.7" "2247.8" "2320.6" "2077.3" "2219.7" "2406.1" "2012.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1612190288293860915" "False" "High" "IsMasterProtein" "P60842" "Eukaryotic initiation factor 4A-I OS=Homo sapiens OX=9606 GN=EIF4A1 PE=1 SV=1" "0.000" "False" "67.275" "29" "13" "27" "9" "406" "46.1" "5.48" "73.91" "13" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1973" "ENSG00000161960" "EIF4A1" "B2R6L8; D3DTP9; hsa:1973; J3QLC4; P04765; P60842; Q5U018; Q61516" "Translation factors; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Interferon type I signaling pathways" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ISG15 antiviral mechanism; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "13" "3" "1.062" "1.029" "1.066" "1.044" "1.109" "0.967" "0.896" "1.008" "1.970" "2037.4" "2164.6" "2096.0" "2172.5" "2126.5" "2259.9" "1969.5" "1826.2" "2052.8" "4013.3" "" "" "" "" "" "" "" "" "" "" "1078.8" "1200.1" "1200.4" "1000.5" "1150.5" "1257.0" "1159.1" "996.8" "1151.6" "4013.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5095696648215945885" "False" "High" "IsMasterProtein" "P09972" "Fructose-bisphosphate aldolase C OS=Homo sapiens OX=9606 GN=ALDOC PE=1 SV=2" "0.000" "False" "67.257" "46" "17" "52" "13" "364" "39.4" "6.87" "176.29" "17" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00274" "230" "ENSG00000109107" "ALDOC" "B2R5R3; hsa:230; P09972; Q3SYL3; Q6FH94; Q6P0L5" "Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Neutrophil degranulation; Glycolysis; Gluconeogenesis" "6" "0" "0.940" "0.978" "1.055" "0.984" "1.044" "0.988" "1.018" "0.937" "0.638" "960.6" "902.8" "939.2" "1013.5" "945.2" "1002.4" "949.0" "977.5" "899.9" "613.0" "" "" "" "" "" "" "" "" "" "" "508.6" "500.5" "537.9" "466.8" "511.4" "557.6" "558.5" "533.6" "504.8" "613.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6737848688669361571" "False" "High" "IsMasterProtein" "Q9UNZ2" "NSFL1 cofactor p47 OS=Homo sapiens OX=9606 GN=NSFL1C PE=1 SV=2" "0.000" "False" "67.156" "44" "14" "22" "14" "370" "40.5" "5.10" "79.35" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00789, Pf08059, Pf14555" "55968" "ENSG00000088833" "NSFL1C" "A2A2L1; B2RD74; hsa:55968; Q5JXA4; Q5JXA5; Q7Z533; Q9H102; Q9NVL9; Q9UI06; Q9UNZ2" "Alstrom syndrome" "RHOH GTPase cycle" "2" "0" "1.074" "1.037" "1.037" "1.064" "1.037" "1.020" "1.049" "1.023" "1.021" "1272.9" "1366.8" "1320.2" "1320.5" "1354.3" "1320.3" "1297.8" "1335.7" "1302.7" "1299.4" "" "" "" "" "" "" "" "" "" "" "674.0" "757.8" "756.1" "608.1" "732.8" "734.4" "763.8" "729.1" "730.8" "1299.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2399497510241032173" "False" "High" "IsMasterProtein" "P25705" "ATP synthase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1A PE=1 SV=1" "0.000" "False" "67.029" "25" "13" "27" "13" "553" "59.7" "9.13" "81.53" "13" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf00006, Pf00306, Pf02874" "498" "ENSG00000152234" "ATP5F1A" "A8K092; B4DY56; hsa:498; K7ENP3; P25705; Q53XX6; Q8IXV2; Q96FB4; Q96HW2; Q96IR6; Q9BTV8" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "Mitochondrial protein import; Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "7" "0" "1.079" "0.982" "1.005" "1.008" "0.922" "1.040" "0.987" "0.966" "0.663" "2002.5" "2160.2" "1965.8" "2012.8" "2018.2" "1846.9" "2082.7" "1977.4" "1934.9" "1327.2" "" "" "" "" "" "" "" "" "" "" "1060.3" "1197.7" "1125.8" "927.0" "1091.9" "1027.3" "1225.7" "1079.3" "1085.4" "1327.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7906499553592381403" "False" "High" "IsMasterProtein" "Q7Z5L9" "Interferon regulatory factor 2-binding protein 2 OS=Homo sapiens OX=9606 GN=IRF2BP2 PE=1 SV=2" "0.000" "False" "66.883" "25" "12" "24" "12" "587" "61.0" "8.69" "78.35" "12" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf11261" "359948" "ENSG00000168264" "IRF2BP2" "B1AM35; B1AM36; hsa:359948; Q6P083; Q7Z5L8; Q7Z5L9; Q8N351; Q8WUH8" "" "" "0" "0" "1.031" "1.089" "1.060" "1.092" "1.050" "1.043" "1.210" "1.152" "0.729" "1465.2" "1510.7" "1595.0" "1552.6" "1600.1" "1538.1" "1527.8" "1773.3" "1687.2" "1068.6" "" "" "" "" "" "" "" "" "" "" "775.8" "837.5" "913.5" "715.0" "865.7" "855.6" "899.1" "967.9" "946.5" "1068.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7048585715635486560" "False" "High" "IsMasterProtein" "Q13885" "Tubulin beta-2A chain OS=Homo sapiens OX=9606 GN=TUBB2A PE=1 SV=1" "0.000" "False" "66.836" "32" "12" "75" "1" "445" "49.9" "4.89" "161.56" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "7280" "ENSG00000137267" "TUBB2A" "hsa:7280; Q13885; Q6FGZ8; Q8IWR2" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; Translocation of SLC2A4 (GLUT4) to the plasma membrane; PKR-mediated signaling; Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "35" "0" "0.978" "0.924" "1.097" "0.987" "1.075" "0.916" "0.820" "0.903" "0.738" "50.6" "49.4" "46.7" "55.5" "49.9" "54.4" "46.3" "41.5" "45.7" "37.3" "" "" "" "" "" "" "" "" "" "" "26.8" "27.4" "26.8" "25.5" "27.0" "30.2" "27.3" "22.6" "25.6" "37.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3028691531671689044" "False" "High" "IsMasterProtein" "Q14697" "Neutral alpha-glucosidase AB OS=Homo sapiens OX=9606 GN=GANAB PE=1 SV=3" "0.000" "False" "66.777" "17" "16" "24" "16" "944" "106.8" "6.14" "69.52" "16" "protein metabolism;other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf01055, Pf13802, Pf21365" "23193" "ENSG00000089597" "GANAB" "A6NC20; hsa:23193; Q14697; Q8WTS9; Q9P0X0" "N-glycan biosynthesis" "Maturation of spike protein; Calnexin/calreticulin cycle; Maturation of spike protein" "5" "0" "1.031" "1.005" "0.970" "1.070" "0.993" "0.931" "0.899" "0.918" "1.961" "1508.7" "1555.0" "1515.9" "1462.8" "1614.4" "1498.1" "1405.0" "1356.2" "1384.8" "2958.2" "" "" "" "" "" "" "" "" "" "" "798.8" "862.2" "868.2" "673.7" "873.5" "833.3" "826.9" "740.3" "776.8" "2958.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6546682892855641805" "False" "High" "IsMasterProtein" "P12268" "Inosine-5'-monophosphate dehydrogenase 2 OS=Homo sapiens OX=9606 GN=IMPDH2 PE=1 SV=2" "0.000" "False" "66.584" "23" "11" "39" "9" "514" "55.8" "6.90" "113.85" "11" "cell cycle OR cell proliferation;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00478, Pf00571" "3615" "ENSG00000178035" "IMPDH2" "hsa:3615; P12268; Q6LEF3" "Rett syndrome" "Potential therapeutics for SARS; Neutrophil degranulation; Purine ribonucleoside monophosphate biosynthesis; Azathioprine ADME" "5" "2" "0.983" "0.968" "0.913" "0.955" "0.958" "0.764" "0.765" "0.769" "0.564" "3266.6" "3210.5" "3163.1" "2983.6" "3118.8" "3130.1" "2494.8" "2498.2" "2512.3" "1843.7" "" "" "" "" "" "" "" "" "" "" "1729.6" "1780.0" "1811.5" "1374.1" "1687.4" "1741.1" "1468.3" "1363.7" "1409.3" "1843.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "565785606400917725" "False" "High" "IsMasterProtein" "P26639" "Threonine--tRNA ligase 1, cytoplasmic OS=Homo sapiens OX=9606 GN=TARS1 PE=1 SV=3" "0.000" "False" "66.547" "24" "19" "31" "19" "723" "83.4" "6.67" "77.84" "19" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf00587, Pf02824, Pf03129, Pf07973" "6897" "ENSG00000113407" "TARS1" "A8K8I1; B4DEG8; hsa:6897; P26639; Q96FP5; Q9BWA6" "" "Cytosolic tRNA aminoacylation" "1" "0" "0.976" "0.962" "0.994" "0.982" "0.978" "0.926" "0.885" "0.933" "0.967" "2098.7" "2049.0" "2019.7" "2086.5" "2061.5" "2051.5" "1943.5" "1857.7" "1957.4" "2029.8" "" "" "" "" "" "" "" "" "" "" "1111.2" "1136.0" "1156.7" "960.9" "1115.4" "1141.2" "1143.8" "1014.0" "1098.1" "2029.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3418914028943411131" "False" "High" "IsMasterProtein" "P29144" "Tripeptidyl-peptidase 2 OS=Homo sapiens OX=9606 GN=TPP2 PE=1 SV=4" "0.000" "False" "66.528" "16" "17" "35" "17" "1249" "138.3" "6.32" "84.20" "17" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00082, Pf12580, Pf12583, Pf21223, Pf21316" "7174" "ENSG00000134900" "TPP2" "hsa:7174; P29144; Q5VZU8" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.997" "1.014" "1.023" "1.050" "1.051" "0.966" "1.006" "1.000" "0.573" "2067.4" "2061.6" "2096.5" "2115.9" "2170.9" "2172.8" "1996.4" "2078.8" "2066.5" "1184.0" "" "" "" "" "" "" "" "" "" "" "1094.7" "1143.0" "1200.6" "974.4" "1174.5" "1208.6" "1175.0" "1134.7" "1159.2" "1184.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8375301801822560127" "False" "High" "IsMasterProtein" "P36776" "Lon protease homolog, mitochondrial OS=Homo sapiens OX=9606 GN=LONP1 PE=1 SV=2" "0.000" "False" "66.138" "16" "14" "25" "14" "959" "106.4" "6.39" "75.31" "14" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00004, Pf02190, Pf05362" "9361" "ENSG00000196365" "LONP1" "B3KPH8; D6W635; E5KMH8; F5GZ27; hsa:9361; P36776; P36777; Q8N8K8; Q9UQ95" "" "Mitochondrial protein degradation" "1" "0" "1.065" "1.087" "1.024" "1.085" "1.083" "0.989" "1.009" "0.931" "0.654" "2241.8" "2388.5" "2436.9" "2295.6" "2432.1" "2428.4" "2216.5" "2262.3" "2086.7" "1465.6" "" "" "" "" "" "" "" "" "" "" "1187.0" "1324.3" "1395.6" "1057.2" "1315.9" "1350.8" "1304.5" "1234.9" "1170.6" "1465.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3614500297026839647" "False" "High" "IsMasterProtein" "Q9Y266" "Nuclear migration protein nudC OS=Homo sapiens OX=9606 GN=NUDC PE=1 SV=1" "0.000" "False" "66.055" "47" "15" "36" "15" "331" "38.2" "5.38" "105.37" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf04969, Pf14050, Pf16273" "10726" "ENSG00000090273" "NUDC" "hsa:10726; Q5QP31; Q5QP35; Q9H0N2; Q9Y266; Q9Y2B6" "Ciliary landscape; PAFAH1B1 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; RND2 GTPase cycle; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "9" "0" "1.034" "1.046" "0.947" "0.996" "0.985" "0.977" "1.024" "1.019" "0.831" "4725.2" "4885.9" "4940.7" "4473.3" "4708.0" "4652.0" "4616.8" "4836.6" "4815.8" "3926.1" "" "" "" "" "" "" "" "" "" "" "2502.0" "2708.9" "2829.5" "2060.1" "2547.2" "2587.7" "2717.2" "2640.1" "2701.6" "3926.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8372900262212064526" "False" "High" "IsMasterProtein" "P09651" "Heterogeneous nuclear ribonucleoprotein A1 OS=Homo sapiens OX=9606 GN=HNRNPA1 PE=1 SV=5" "0.000" "False" "65.909" "40" "14" "55" "9" "372" "38.7" "9.13" "150.94" "14" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf11627" "3178" "ENSG00000135486" "HNRNPA1" "A8K4Z8; hsa:3178; P09651; Q3MIB7; Q6PJZ7" "mRNA processing" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; SARS-CoV-1-host interactions; SARS-CoV-1 modulates host translation machinery" "6" "1" "0.948" "1.040" "0.930" "0.938" "0.987" "0.852" "0.886" "0.890" "1.110" "2709.7" "2569.4" "2819.2" "2519.7" "2540.3" "2673.6" "2308.3" "2400.3" "2411.7" "3008.3" "" "" "" "" "" "" "" "" "" "" "1434.8" "1424.6" "1614.6" "1160.4" "1374.4" "1487.2" "1358.5" "1310.2" "1352.9" "3008.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4532618803689773049" "False" "High" "IsMasterProtein" "P00491" "Purine nucleoside phosphorylase OS=Homo sapiens OX=9606 GN=PNP PE=1 SV=2" "0.000" "False" "65.734" "37" "10" "37" "10" "289" "32.1" "6.95" "80.97" "10" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf01048" "4860" "ENSG00000198805; ENSG00000291814" "PNP" "B2R8S5; D3DS00; hsa:4860; P00491; Q15160; Q5PZ03" "VEGFA-VEGFR2 signaling" "Neutrophil degranulation; Purine catabolism; Ribavirin ADME; Purine salvage; Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine" "6" "0" "1.002" "0.969" "1.031" "1.029" "1.016" "1.026" "1.025" "1.039" "0.677" "2111.0" "2114.6" "2045.9" "2177.2" "2173.3" "2144.2" "2166.7" "2163.5" "2193.0" "1428.9" "" "" "" "" "" "" "" "" "" "" "1117.8" "1172.4" "1171.7" "1002.6" "1175.8" "1192.7" "1275.2" "1181.0" "1230.2" "1428.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8321804652329171157" "False" "High" "IsMasterProtein" "Q9BXJ9" "N-alpha-acetyltransferase 15, NatA auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA15 PE=1 SV=1" "0.000" "False" "65.503" "20" "19" "35" "19" "866" "101.2" "7.42" "95.70" "19" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity" "Pf12569, Pf13181" "80155" "ENSG00000164134" "NAA15" "D3DNY6; Q52LG9; Q8IWH4; Q8NEV2; Q9BXJ9; Q9H8P6" "" "" "0" "0" "0.984" "0.970" "0.957" "0.990" "0.982" "0.948" "0.974" "0.929" "0.598" "3761.2" "3702.6" "3649.8" "3600.6" "3723.5" "3694.4" "3564.7" "3662.0" "3493.6" "2249.1" "" "" "" "" "" "" "" "" "" "" "1991.6" "2052.8" "2090.2" "1658.2" "2014.6" "2055.0" "2098.0" "1998.9" "1959.8" "2249.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6560846777174153588" "False" "High" "IsMasterProtein" "P53621" "Coatomer subunit alpha OS=Homo sapiens OX=9606 GN=COPA PE=1 SV=2" "0.000" "False" "65.283" "15" "18" "26" "18" "1224" "138.3" "7.66" "74.27" "18" "transport;signal transduction" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00400, Pf04053, Pf06957" "1314" "ENSG00000122218" "COPA" "hsa:1314; P53621; Q5T201; Q8IXZ9" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "2" "0" "0.992" "0.946" "0.912" "0.958" "1.023" "0.969" "0.890" "0.961" "1.369" "2081.2" "2063.5" "1968.9" "1897.4" "1994.0" "2128.9" "2016.9" "1853.2" "1999.9" "2849.8" "" "" "" "" "" "" "" "" "" "" "1102.0" "1144.1" "1127.6" "873.8" "1078.8" "1184.2" "1187.0" "1011.6" "1121.9" "2849.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6653265809957974706" "False" "High" "IsMasterProtein" "Q14157" "Ubiquitin-associated protein 2-like OS=Homo sapiens OX=9606 GN=UBAP2L PE=1 SV=2" "0.000" "False" "65.064" "15" "13" "19" "13" "1087" "114.5" "7.11" "64.20" "13" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf12478" "9898" "ENSG00000143569" "UBAP2L" "B4E0U8; hsa:9898; Q14157; Q5VU75; Q5VU76; Q9BTU3; Q9UGL2; Q9UGL3; Q9UGL4; Q9UGL5" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.934" "1.060" "0.980" "0.930" "0.923" "0.881" "1.005" "0.942" "0.527" "2367.2" "2211.7" "2509.2" "2320.9" "2202.6" "2184.6" "2085.4" "2378.6" "2228.9" "1247.7" "" "" "" "" "" "" "" "" "" "" "1253.5" "1226.3" "1437.0" "1068.8" "1191.7" "1215.2" "1227.3" "1298.4" "1250.4" "1247.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2657182436335150623" "False" "High" "IsMasterProtein" "Q9Y3I0" "RNA-splicing ligase RtcB homolog OS=Homo sapiens OX=9606 GN=RTCB PE=1 SV=1" "0.000" "False" "65.048" "30" "14" "20" "14" "505" "55.2" "7.23" "58.36" "14" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01139" "51493" "ENSG00000100220" "RTCB" "B2R6A8; hsa:51493; Q6IAI0; Q9BWL4; Q9NTH1; Q9P037; Q9P0J3; Q9Y3I0" "Unfolded protein response" "tRNA processing in the nucleus" "2" "0" "1.005" "1.047" "1.051" "1.104" "1.108" "1.200" "1.283" "1.240" "0.957" "1944.8" "1954.9" "2036.2" "2044.2" "2146.3" "2154.7" "2334.0" "2495.8" "2410.9" "1861.4" "" "" "" "" "" "" "" "" "" "" "1029.8" "1083.8" "1166.1" "941.4" "1161.3" "1198.6" "1373.7" "1362.3" "1352.4" "1861.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3757999433169180156" "False" "High" "IsMasterProtein" "Q9NTJ3" "Structural maintenance of chromosomes protein 4 OS=Homo sapiens OX=9606 GN=SMC4 PE=1 SV=2" "0.000" "False" "65.024" "11" "15" "19" "15" "1288" "147.1" "6.79" "56.42" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "10051" "ENSG00000113810" "SMC4" "A6NLT9; D3DNL8; hsa:10051; O95752; Q8NDL4; Q9NTJ3; Q9UNT9" "Ciliary landscape" "Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes" "3" "0" "1.061" "0.994" "1.044" "1.063" "1.036" "0.978" "0.386" "0.950" "7.580" "715.1" "758.4" "710.8" "746.9" "760.0" "741.1" "699.0" "276.3" "679.0" "5420.6" "" "" "" "" "" "" "" "" "" "" "378.6" "420.5" "407.1" "344.0" "411.2" "412.3" "411.4" "150.8" "380.9" "5420.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5545156882891984968" "False" "High" "IsMasterProtein" "P07954" "Fumarate hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=FH PE=1 SV=3" "0.000" "False" "64.432" "24" "12" "30" "12" "510" "54.6" "8.76" "84.27" "12" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00206, Pf10415" "2271" "ENSG00000091483" "FH" "B1ANK7; hsa:2271; P07954" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Krebs cycle disorders; Type 2 papillary renal cell carcinoma; Metabolic reprogramming in colon cancer; TCA cycle in senescence; TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "9" "0" "0.975" "0.968" "0.974" "0.935" "0.948" "0.833" "0.887" "0.824" "0.563" "3603.7" "3513.1" "3488.4" "3510.8" "3371.2" "3416.5" "3003.4" "3196.5" "2969.4" "2030.1" "" "" "" "" "" "" "" "" "" "" "1908.2" "1947.7" "1997.8" "1616.8" "1823.9" "1900.4" "1767.6" "1744.8" "1665.7" "2030.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1547781430018805415" "False" "High" "IsMasterProtein" "P30101" "Protein disulfide-isomerase A3 OS=Homo sapiens OX=9606 GN=PDIA3 PE=1 SV=4" "0.000" "False" "64.323" "27" "13" "20" "13" "505" "56.7" "6.35" "57.63" "13" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00085, Pf13848" "2923" "ENSG00000167004" "PDIA3" "hsa:2923; P30101; Q13453; Q14255; Q8IYF8; Q9UMU7" "Prion disease pathway" "ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle" "4" "0" "0.981" "0.985" "0.927" "0.984" "1.000" "0.908" "0.855" "1.029" "3.111" "1373.5" "1347.2" "1352.9" "1273.0" "1351.7" "1373.2" "1247.3" "1174.6" "1413.3" "4273.0" "" "" "" "" "" "" "" "" "" "" "727.3" "746.9" "774.8" "586.2" "731.3" "763.8" "734.1" "641.2" "792.9" "4273.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6973365880698085835" "False" "High" "IsMasterProtein" "Q9UHD8" "Septin-9 OS=Homo sapiens OX=9606 GN=SEPTIN9 PE=1 SV=2" "0.000" "False" "64.309" "24" "15" "30" "15" "586" "65.4" "8.97" "78.16" "15" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00735" "10801" "ENSG00000184640" "SEPTIN9" "A8K2V3; B3KPM0; B4DTL9; B4E0N2; B4E274; B7Z654; hsa:10801; Q96QF3; Q96QF4; Q96QF5; Q9HA04; Q9UG40; Q9UHD8; Q9Y5W4" "" "" "0" "0" "0.963" "0.981" "0.989" "0.988" "0.977" "1.006" "1.003" "0.967" "0.627" "2889.7" "2782.9" "2835.7" "2856.9" "2854.9" "2822.9" "2907.4" "2898.1" "2793.2" "1812.2" "" "" "" "" "" "" "" "" "" "" "1530.1" "1542.9" "1624.0" "1315.7" "1544.6" "1570.2" "1711.1" "1582.0" "1566.9" "1812.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5903683586191117105" "False" "High" "IsMasterProtein" "Q13200" "26S proteasome non-ATPase regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PSMD2 PE=1 SV=3" "0.000" "False" "63.813" "15" "17" "28" "17" "908" "100.1" "5.20" "73.22" "17" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01851, Pf17781, Pf18051" "5708" "ENSG00000175166" "PSMD2" "B4DX07; B4DXY1; E7EW34; E9PCS3; hsa:5708; Q12932; Q13200; Q15321; Q53XQ4; Q96I12" "Proteasome degradation; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; Downstream TCR signaling; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "65" "0" "0.963" "1.057" "0.941" "1.008" "1.012" "0.893" "0.943" "0.941" "0.637" "2187.2" "2106.7" "2311.6" "2059.1" "2205.3" "2213.0" "1953.7" "2062.9" "2057.8" "1393.5" "" "" "" "" "" "" "" "" "" "" "1158.1" "1168.0" "1323.9" "948.3" "1193.1" "1231.0" "1149.8" "1126.1" "1154.4" "1393.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6979633451004201219" "False" "High" "IsMasterProtein" "P31946" "14-3-3 protein beta/alpha OS=Homo sapiens OX=9606 GN=YWHAB PE=1 SV=3" "0.000" "False" "63.677" "63" "13" "75" "6" "246" "28.1" "4.83" "168.70" "13" "signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00244" "7529" "ENSG00000166913" "YWHAB" "A8K9K2; E1P616; hsa:7529; P31946" "Cell cycle; IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Hepatitis B infection; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Regulation of localization of FOXO transcription factors; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Signaling by Hippo; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Rap1 signalling; Negative regulation of MAPK pathway; Frs2-mediated activation; ARMS-mediated activation; Activation of BAD and translocation to mitochondria ; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "33" "0" "1.107" "1.131" "0.989" "1.090" "1.063" "1.042" "1.166" "1.107" "0.744" "1061.0" "1174.2" "1199.7" "1049.2" "1157.0" "1128.0" "1105.5" "1237.5" "1174.2" "789.6" "" "" "" "" "" "" "" "" "" "" "561.8" "651.0" "687.1" "483.2" "626.0" "627.4" "650.6" "675.5" "658.7" "789.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4058456233631452436" "False" "High" "IsMasterProtein" "Q06830" "Peroxiredoxin-1 OS=Homo sapiens OX=9606 GN=PRDX1 PE=1 SV=1" "0.000" "False" "63.613" "49" "10" "73" "7" "199" "22.1" "8.13" "201.16" "10" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00578, Pf10417" "5052" "ENSG00000117450" "PRDX1" "B5BU26; D3DPZ8; hsa:5052; P35703; Q06830; Q2V576; Q5T154; Q5T155" "Androgen receptor signaling pathway; Selenium micronutrient network; Nuclear receptors meta-pathway; NRF2 pathway; HDAC6 interactions in the central nervous system" "Detoxification of Reactive Oxygen Species; TP53 Regulates Metabolic Genes; NFE2L2 regulating anti-oxidant/detoxification enzymes; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "9" "3" "0.981" "1.002" "0.992" "0.984" "0.983" "0.969" "1.010" "0.956" "0.639" "6034.2" "5920.5" "6047.5" "5985.3" "5939.6" "5932.5" "5845.9" "6097.0" "5769.0" "3856.5" "" "" "" "" "" "" "" "" "" "" "3195.1" "3282.5" "3463.4" "2756.4" "3213.5" "3299.9" "3440.5" "3328.1" "3236.2" "3856.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1853475733980272119" "False" "High" "IsMasterProtein" "P17858" "ATP-dependent 6-phosphofructokinase, liver type OS=Homo sapiens OX=9606 GN=PFKL PE=1 SV=6" "0.000" "False" "63.602" "17" "15" "30" "9" "780" "85.0" "7.50" "83.32" "15" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "kinase activity;other molecular function" "Pf00365" "5211" "ENSG00000141959" "PFKL" "hsa:5211; P17858; Q96A64; Q96IH4; Q9BR91" "Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Insulin signaling; Disorders of fructose metabolism; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Neutrophil degranulation" "9" "1" "0.986" "0.962" "0.959" "1.003" "0.964" "0.954" "0.939" "0.960" "0.547" "2070.6" "2041.7" "1991.1" "1986.5" "2075.9" "1995.1" "1975.0" "1944.0" "1987.9" "1132.4" "" "" "" "" "" "" "" "" "" "" "1096.4" "1132.0" "1140.3" "914.9" "1123.2" "1109.8" "1162.4" "1061.1" "1115.2" "1132.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1618262664170988145" "False" "High" "IsMasterProtein" "P61978" "Heterogeneous nuclear ribonucleoprotein K OS=Homo sapiens OX=9606 GN=HNRNPK PE=1 SV=1" "0.000" "False" "63.034" "29" "16" "44" "16" "463" "50.9" "5.54" "120.68" "16" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf08067" "3190" "ENSG00000165119" "HNRNPK" "hsa:3190; P61978; Q07244; Q15671; Q59F98; Q5T6W4; Q60577; Q6IBN1; Q922Y7; Q96J62" "mRNA processing; lncRNA in canonical Wnt signaling and colorectal cancer" "mRNA Splicing - Major Pathway; HCMV Late Events; SUMOylation of RNA binding proteins; Processing of Capped Intron-Containing Pre-mRNA" "6" "0" "0.994" "0.996" "0.967" "0.982" "0.997" "0.992" "0.933" "1.001" "2.035" "4001.8" "3977.7" "3984.4" "3870.0" "3928.9" "3990.1" "3968.9" "3732.5" "4007.5" "8145.5" "" "" "" "" "" "" "" "" "" "" "2118.9" "2205.4" "2281.8" "1782.3" "2125.7" "2219.5" "2335.8" "2037.4" "2248.1" "8145.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5459324364456559330" "False" "High" "IsMasterProtein" "Q04637" "Eukaryotic translation initiation factor 4 gamma 1 OS=Homo sapiens OX=9606 GN=EIF4G1 PE=1 SV=4" "0.000" "False" "62.968" "11" "18" "33" "17" "1599" "175.4" "5.33" "64.31" "18" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02020, Pf02847, Pf02854" "1981" "ENSG00000114867" "EIF4G1" "D3DNT2; D3DNT4; D3DNT5; E9PFM1; G5E9S1; hsa:1981; O43177; O95066; Q04637; Q5HYG0; Q6ZN21; Q8N102" "Translation factors; VEGFA-VEGFR2 signaling; Acute viral myocarditis; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Pleural mesothelioma" "AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; ISG15 antiviral mechanism; mTORC1-mediated signalling; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "20" "0" "0.934" "0.866" "1.066" "0.971" "0.933" "1.175" "0.788" "1.206" "6.089" "714.1" "667.0" "618.5" "761.1" "693.5" "666.3" "839.1" "562.3" "861.5" "4348.0" "" "" "" "" "" "" "" "" "" "" "378.1" "369.8" "354.2" "350.5" "375.2" "370.6" "493.8" "307.0" "483.3" "4348.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5165886701298417594" "False" "High" "IsMasterProtein" "Q15459" "Splicing factor 3A subunit 1 OS=Homo sapiens OX=9606 GN=SF3A1 PE=1 SV=1" "0.000" "False" "62.845" "16" "13" "21" "13" "793" "88.8" "5.22" "61.64" "13" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00240, Pf01805, Pf12230" "10291" "ENSG00000099995" "SF3A1" "E9PAW1; hsa:10291; Q15459" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.981" "1.014" "1.036" "1.036" "1.066" "1.060" "1.045" "1.141" "1.441" "1357.5" "1331.0" "1377.1" "1405.9" "1406.2" "1446.9" "1438.5" "1419.2" "1549.0" "1956.1" "" "" "" "" "" "" "" "" "" "" "718.8" "738.0" "788.7" "647.5" "760.8" "804.9" "846.6" "774.7" "868.9" "1956.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3602445909866352508" "False" "High" "IsMasterProtein" "P19338" "Nucleolin OS=Homo sapiens OX=9606 GN=NCL PE=1 SV=3" "0.000" "False" "62.655" "23" "20" "31" "20" "710" "76.6" "4.70" "91.52" "20" "developmental processes;other biological processes" "plasma membrane;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "4691" "ENSG00000115053" "NCL" "hsa:4691; P19338; Q53SK1; Q8NB06; Q9UCF0; Q9UDG1" "Pathogenic Escherichia coli infection; VEGFA-VEGFR2 signaling" "Major pathway of rRNA processing in the nucleolus and cytosol; Respiratory syncytial virus (RSV) attachment and entry" "4" "0" "0.992" "1.149" "1.004" "0.965" "0.920" "1.366" "1.441" "1.530" "1.691" "3547.2" "3518.8" "4075.0" "3560.4" "3422.0" "3264.6" "4846.4" "5112.7" "5427.4" "5999.0" "" "" "" "" "" "" "" "" "" "" "1878.3" "1950.9" "2333.7" "1639.7" "1851.4" "1815.9" "2852.3" "2790.8" "3044.6" "5999.0" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1964707792463719030" "False" "High" "IsMasterProtein" "O43776" "Asparagine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=NARS1 PE=1 SV=1" "0.000" "False" "62.252" "23" "13" "25" "13" "548" "62.9" "6.25" "88.30" "13" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00152, Pf01336, Pf20917" "4677" "ENSG00000134440" "NARS1" "B4DG16; hsa:4677; O43776; Q53GU6" "Photodynamic therapy-induced unfolded protein response" "Cytosolic tRNA aminoacylation" "2" "0" "1.013" "0.997" "0.950" "1.008" "0.965" "0.828" "0.873" "0.870" "0.569" "1991.2" "2017.4" "1986.1" "1891.4" "2008.0" "1921.4" "1648.6" "1738.3" "1732.2" "1132.2" "" "" "" "" "" "" "" "" "" "" "1054.3" "1118.5" "1137.5" "871.0" "1086.4" "1068.8" "970.3" "948.9" "971.7" "1132.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5136159273712408888" "False" "High" "IsMasterProtein" "P38919" "Eukaryotic initiation factor 4A-III OS=Homo sapiens OX=9606 GN=EIF4A3 PE=1 SV=4" "0.000" "False" "61.694" "29" "13" "24" "13" "411" "46.8" "6.73" "61.67" "13" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "9775" "ENSG00000141543; ENSG00000291508" "EIF4A3" "hsa:9775; P38919; Q15033; Q6IBQ2; Q96A18" "TAR syndrome" "mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; ISG15 antiviral mechanism; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "11" "0" "0.972" "0.955" "0.930" "0.969" "1.051" "0.887" "0.896" "0.902" "0.722" "1758.5" "1708.7" "1679.0" "1635.1" "1704.5" "1849.0" "1560.1" "1575.6" "1585.7" "1269.1" "" "" "" "" "" "" "" "" "" "" "931.1" "947.3" "961.5" "753.0" "922.2" "1028.5" "918.2" "860.1" "889.5" "1269.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "172904709922305924" "False" "High" "IsMasterProtein" "Q5UIP0" "Telomere-associated protein RIF1 OS=Homo sapiens OX=9606 GN=RIF1 PE=1 SV=2" "0.000" "False" "61.427" "7" "14" "15" "14" "2472" "274.3" "5.52" "44.97" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "" "Pf12231" "55183" "ENSG00000080345" "RIF1" "A6NC27; C9JBR1; hsa:55183; Q5H9R3; Q5UIP0; Q5UIP2; Q66YK6; Q6PRU2; Q8TE94; Q99772; Q9H830; Q9H9B9; Q9NVP5; Q9Y4R4" "ATM signaling in development and disease ; 10q11.21q11.23 copy number variation syndrome" "Nonhomologous End-Joining (NHEJ)" "3" "0" "0.958" "1.028" "1.316" "1.219" "1.157" "2.445" "2.524" "2.399" "2.531" "667.0" "638.8" "685.7" "877.5" "813.2" "771.6" "1630.7" "1683.5" "1600.0" "1688.0" "" "" "" "" "" "" "" "" "" "" "353.2" "354.1" "392.7" "404.1" "439.9" "429.2" "959.7" "918.9" "897.6" "1688.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2832146552711634492" "False" "High" "IsMasterProtein" "Q02218" "2-oxoglutarate dehydrogenase complex component E1 OS=Homo sapiens OX=9606 GN=OGDH PE=1 SV=3" "0.000" "False" "61.359" "14" "13" "19" "13" "1023" "115.9" "6.86" "55.28" "13" "protein metabolism;other metabolic processes;developmental processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00676, Pf02779, Pf16078, Pf16870" "4967" "ENSG00000105953" "OGDH" "B4E2U9; D3DVL0; E9PBM1; hsa:4967; Q02218; Q96DD3; Q9UDX0" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Thiamine metabolic pathways; 7q11.23 copy number variation syndrome; TCA cycle (aka Krebs or citric acid cycle)" "Mitochondrial protein degradation; Lysine catabolism; Glyoxylate metabolism and glycine degradation; Citric acid cycle (TCA cycle)" "9" "0" "0.930" "0.961" "0.887" "0.961" "0.966" "0.820" "0.841" "0.842" "0.735" "1765.3" "1642.0" "1696.5" "1566.1" "1695.6" "1706.1" "1447.6" "1483.9" "1486.7" "1296.9" "" "" "" "" "" "" "" "" "" "" "934.7" "910.4" "971.6" "721.3" "917.4" "949.0" "852.0" "810.0" "834.0" "1296.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2411801021050745689" "False" "High" "IsMasterProtein" "Q9NSE4" "Isoleucine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=IARS2 PE=1 SV=2" "0.000" "False" "61.034" "17" "15" "27" "15" "1012" "113.7" "7.20" "54.76" "15" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00133, Pf06827, Pf08264" "55699" "ENSG00000067704" "IARS2" "B2RPG8; hsa:55699; Q1M2P9; Q6PI85; Q7L439; Q86WU9; Q96D91; Q9H9Q8; Q9NSE4; Q9NW42" "" "Mitochondrial protein degradation; Mitochondrial tRNA aminoacylation" "2" "0" "1.002" "1.011" "1.011" "1.006" "1.066" "0.947" "0.959" "0.928" "0.586" "1825.1" "1828.7" "1845.8" "1845.4" "1835.2" "1945.6" "1727.9" "1750.6" "1694.3" "1068.8" "" "" "" "" "" "" "" "" "" "" "966.4" "1013.9" "1057.1" "849.9" "992.9" "1082.2" "1016.9" "955.5" "950.4" "1068.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8785242188080332383" "False" "High" "IsMasterProtein" "P28838" "Cytosol aminopeptidase OS=Homo sapiens OX=9606 GN=LAP3 PE=1 SV=3" "0.000" "False" "60.984" "28" "13" "22" "13" "519" "56.1" "7.93" "61.52" "13" "protein metabolism" "other cell component" "other molecular function" "Pf00883, Pf02789" "51056" "ENSG00000002549" "LAP3" "B3KMQ3; hsa:51056; P28838; Q6IAM6; Q6P0L6; Q9UQE3" "" "" "0" "0" "1.021" "1.079" "0.977" "1.021" "1.033" "1.010" "0.993" "1.000" "0.968" "1991.7" "2034.1" "2148.4" "1945.8" "2032.5" "2056.7" "2011.0" "1977.8" "1992.3" "1928.2" "" "" "" "" "" "" "" "" "" "" "1054.6" "1127.7" "1230.4" "896.1" "1099.7" "1144.0" "1183.5" "1079.6" "1117.6" "1928.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7081455264055243390" "False" "High" "IsMasterProtein" "Q16658" "Fascin OS=Homo sapiens OX=9606 GN=FSCN1 PE=1 SV=3" "0.000" "False" "60.562" "25" "14" "30" "14" "493" "54.5" "7.24" "80.45" "14" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf06268" "6624" "ENSG00000075618" "FSCN1" "A6NI89; B2RE97; hsa:6624; Q16658; Q96IC5; Q96IH1; Q9BRF1" "VEGFA-VEGFR2 signaling; Urotensin-II-mediated signaling pathway" "Interleukin-4 and Interleukin-13 signaling" "3" "0" "0.982" "1.025" "0.996" "0.978" "1.033" "0.989" "1.001" "0.948" "0.679" "2892.7" "2839.6" "2965.1" "2882.1" "2828.6" "2987.3" "2861.0" "2895.0" "2742.8" "1964.7" "" "" "" "" "" "" "" "" "" "" "1531.7" "1574.4" "1698.1" "1327.3" "1530.4" "1661.7" "1683.8" "1580.2" "1538.6" "1964.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6011940264998513028" "False" "High" "IsMasterProtein" "O00429" "Dynamin-1-like protein OS=Homo sapiens OX=9606 GN=DNM1L PE=1 SV=2" "0.000" "False" "60.551" "21" "19" "30" "19" "736" "81.8" "6.81" "78.62" "19" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00350, Pf01031, Pf02212" "10059" "ENSG00000087470" "DNM1L" "A8K4X9; B4DGC9; B4DSU8; G8JLD5; hsa:10059; J3KPI2; O00429; O14541; O60709; Q59GN9; Q7L6B3; Q8TBT7; Q9BWM1; Q9Y5J2" "Synaptic vesicle pathway; CAMKK2 pathway" "Apoptotic execution phase" "3" "0" "0.969" "0.981" "0.950" "0.994" "1.030" "0.844" "0.850" "0.863" "0.846" "2834.3" "2745.4" "2779.5" "2693.1" "2817.7" "2919.2" "2391.9" "2409.8" "2444.6" "2397.8" "" "" "" "" "" "" "" "" "" "" "1500.8" "1522.1" "1591.8" "1240.3" "1524.5" "1623.8" "1407.7" "1315.4" "1371.4" "2397.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7845595134204648988" "False" "High" "IsMasterProtein" "Q8NE71" "ATP-binding cassette sub-family F member 1 OS=Homo sapiens OX=9606 GN=ABCF1 PE=1 SV=2" "0.000" "False" "60.542" "14" "11" "23" "11" "845" "95.9" "6.80" "63.45" "11" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00005" "23" "ENSG00000204574; ENSG00000206490; ENSG00000225989; ENSG00000231129; ENSG00000232169; ENSG00000236149; ENSG00000236342" "ABCF1" "A2BF75; hsa:23; O14897; Q69YP6; Q8NE71" "IL-18 signaling pathway" "ABC-family proteins mediated transport" "2" "0" "0.985" "0.991" "1.117" "1.068" "1.054" "0.909" "1.006" "0.930" "0.762" "831.8" "819.0" "824.5" "928.9" "888.5" "876.6" "755.8" "836.8" "773.3" "634.2" "" "" "" "" "" "" "" "" "" "" "440.5" "454.1" "472.2" "427.8" "480.7" "487.6" "444.8" "456.7" "433.8" "634.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1011976368699827672" "False" "High" "IsMasterProtein" "P41091" "Eukaryotic translation initiation factor 2 subunit 3 OS=Homo sapiens OX=9606 GN=EIF2S3 PE=1 SV=3" "0.000" "False" "60.449" "25" "11" "27" "11" "472" "51.1" "8.40" "73.59" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03144, Pf09173" "1968" "ENSG00000130741" "EIF2S3" "A0A024RBY4; A8K2Y2; B2R5N2; B5BTZ4; hsa:1968; P41091; Q53HK3" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "PERK regulates gene expression; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; PKR-mediated signaling; Formation of the ternary complex, and subsequently, the 43S complex; Response of EIF2AK1 (HRI) to heme deficiency; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency; Cellular response to mitochondrial stress" "14" "0" "0.987" "0.995" "1.041" "1.023" "1.034" "0.984" "1.005" "0.927" "0.650" "2789.8" "2752.3" "2776.1" "2905.1" "2852.9" "2884.2" "2745.6" "2802.5" "2586.5" "1814.1" "" "" "" "" "" "" "" "" "" "" "1477.2" "1526.0" "1589.9" "1337.9" "1543.5" "1604.3" "1615.9" "1529.7" "1450.9" "1814.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "325736081283403068" "False" "High" "IsMasterProtein" "P35637" "RNA-binding protein FUS OS=Homo sapiens OX=9606 GN=FUS PE=1 SV=1" "0.000" "False" "60.423" "20" "8" "31" "6" "526" "53.4" "9.36" "85.22" "8" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00641" "2521" "ENSG00000089280" "FUS" "hsa:2521; P35637; Q9H4A8" "MECP2 and associated Rett syndrome; mRNA processing; HDAC6 interactions in the central nervous system" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "5" "2" "0.950" "1.061" "0.971" "0.942" "0.899" "0.889" "1.046" "0.919" "0.503" "3310.1" "3145.0" "3511.3" "3214.2" "3118.8" "2976.9" "2941.7" "3463.2" "3043.5" "1664.7" "" "" "" "" "" "" "" "" "" "" "1752.7" "1743.7" "2010.9" "1480.2" "1687.4" "1655.9" "1731.3" "1890.4" "1707.3" "1664.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2550625188107110862" "False" "High" "IsMasterProtein" "P14550" "Aldo-keto reductase family 1 member A1 OS=Homo sapiens OX=9606 GN=AKR1A1 PE=1 SV=3" "0.000" "False" "60.391" "41" "13" "21" "13" "325" "36.6" "6.79" "56.61" "13" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00248" "10327" "ENSG00000117448" "AKR1A1" "A8KAL8; D3DQ04; hsa:10327; P14550; Q6IAZ4" "Benzo(a)pyrene metabolism; Metapathway biotransformation Phase I and II" "Glutathione conjugation; Formation of xylulose-5-phosphate" "4" "0" "0.984" "0.936" "0.948" "0.978" "1.020" "0.857" "0.822" "0.877" "0.989" "2315.3" "2279.2" "2167.1" "2195.4" "2264.3" "2361.6" "1983.6" "1903.7" "2029.8" "2288.9" "" "" "" "" "" "" "" "" "" "" "1225.9" "1263.6" "1241.1" "1011.0" "1225.1" "1313.7" "1167.4" "1039.2" "1138.7" "2288.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7785579833791404998" "False" "High" "IsMasterProtein" "P17980" "26S proteasome regulatory subunit 6A OS=Homo sapiens OX=9606 GN=PSMC3 PE=1 SV=3" "0.000" "False" "60.370" "38" "14" "25" "14" "439" "49.2" "5.24" "63.60" "14" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5702" "ENSG00000165916" "PSMC3" "B2R8V1; hsa:5702; P17980; Q3B757; Q3B865; Q53HU5; Q6GPG8; Q6IBS1; Q96HD3" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Neutrophil degranulation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "1.033" "0.985" "1.009" "0.921" "0.989" "0.833" "0.927" "0.886" "0.609" "2532.8" "2615.8" "2495.7" "2555.6" "2332.4" "2504.5" "2108.5" "2348.7" "2243.2" "1542.5" "" "" "" "" "" "" "" "" "" "" "1341.1" "1450.3" "1429.3" "1176.9" "1261.9" "1393.1" "1240.9" "1282.0" "1258.4" "1542.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5836622772794954890" "False" "High" "IsMasterProtein" "P06400" "Retinoblastoma-associated protein OS=Homo sapiens OX=9606 GN=RB1 PE=1 SV=2" "0.000" "False" "59.418" "18" "17" "21" "17" "928" "106.1" "7.94" "53.20" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01857, Pf01858, Pf08934, Pf11934" "5925" "ENSG00000139687" "RB1" "A8K5E3; hsa:5925; P06400; P78499; Q5VW46; Q8IZL4" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Adipogenesis; Spinal cord injury; Retinoblastoma gene in cancer; Aryl hydrocarbon receptor pathway; Bladder cancer; Fas ligand pathway and stress induction of heat shock proteins; Photodynamic therapy-induced AP-1 survival signaling; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Tumor suppressor activity of SMARCB1; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Effect of progerin on genes involved in progeria; Ciliary landscape; G1 to S cell cycle control; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Overlap between signal transduction pathways contributing to LMNA laminopathies; 7q11.23 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; Sphingolipid metabolism in senescence; Prostaglandin and leukotriene metabolism in senescence ; ID signaling pathway; TROP2 regulatory signaling; Prostaglandin and leukotriene metabolism in senescence ; 8q11.23 (RB1CC1) copy number variation; Omega-6-fatty acids in senescence; DNA damage response" "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Oncogene Induced Senescence; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Aberrant regulation of mitotic exit in cancer due to RB1 defects; RUNX2 regulates osteoblast differentiation; Condensation of Prophase Chromosomes; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; Cyclin A:Cdk2-associated events at S phase entry; Formation of Senescence-Associated Heterochromatin Foci (SAHF); Inhibition of replication initiation of damaged DNA by RB1/E2F1; Defective translocation of RB1 mutants to the nucleus; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome; Nuclear events stimulated by ALK signaling in cancer" "51" "0" "1.018" "0.968" "0.924" "0.879" "0.834" "0.746" "0.740" "0.777" "0.619" "2812.2" "2863.1" "2721.6" "2597.3" "2471.0" "2344.3" "2099.1" "2081.4" "2183.8" "1740.6" "" "" "" "" "" "" "" "" "" "" "1489.1" "1587.4" "1558.7" "1196.1" "1336.9" "1304.0" "1235.4" "1136.1" "1225.0" "1740.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6939588679820243468" "False" "High" "IsMasterProtein" "P23193" "Transcription elongation factor A protein 1 OS=Homo sapiens OX=9606 GN=TCEA1 PE=1 SV=2" "0.000" "False" "59.256" "38" "10" "16" "10" "301" "33.9" "8.38" "52.84" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01096, Pf07500, Pf08711" "6917" "ENSG00000187735" "TCEA1" "A6NF25; A8K339; hsa:6917; P23193; Q15563; Q6FG87" "" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "15" "0" "1.069" "1.107" "1.064" "1.050" "1.082" "1.124" "1.316" "1.262" "0.755" "1619.1" "1730.4" "1792.4" "1722.4" "1700.5" "1752.1" "1819.7" "2130.0" "2043.5" "1222.0" "" "" "" "" "" "" "" "" "" "" "857.3" "959.4" "1026.5" "793.2" "920.0" "974.6" "1071.0" "1162.7" "1146.3" "1222.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8220013005457955452" "False" "High" "IsMasterProtein" "Q15424" "Scaffold attachment factor B1 OS=Homo sapiens OX=9606 GN=SAFB PE=1 SV=4" "0.000" "False" "59.250" "16" "16" "23" "11" "915" "102.6" "5.47" "64.21" "16" "cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf02037" "6294" "ENSG00000160633" "SAFB" "A0AV56; B7Z5B6; B7ZLP6; F5H0H3; hsa:6294; O60406; Q15424; Q59HH8" "Interleukin-1 (IL-1) structural pathway" "SUMOylation of transcription cofactors" "2" "3" "0.945" "1.066" "1.194" "0.981" "1.015" "1.211" "1.406" "1.248" "0.505" "2209.8" "2089.3" "2354.6" "2637.9" "2167.2" "2242.4" "2675.0" "3107.5" "2757.9" "1115.0" "" "" "" "" "" "" "" "" "" "" "1170.1" "1158.4" "1348.5" "1214.9" "1172.5" "1247.3" "1574.3" "1696.2" "1547.1" "1115.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8117017983706301691" "False" "High" "IsMasterProtein" "P27348" "14-3-3 protein theta OS=Homo sapiens OX=9606 GN=YWHAQ PE=1 SV=1" "0.000" "False" "59.097" "51" "12" "63" "7" "245" "27.7" "4.78" "151.62" "12" "signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00244" "10971" "ENSG00000134308" "YWHAQ" "D6W4Z5; hsa:10971; P27348; Q567U5; Q5TZU8; Q9UP48" "Cell cycle; Pathogenic Escherichia coli infection; Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Leukocyte-intrinsic Hippo pathway functions; Hepatitis B infection; Opioid receptor pathways; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria" "19" "0" "0.942" "1.041" "0.907" "0.938" "0.960" "0.827" "1.123" "0.966" "0.734" "1273.6" "1199.3" "1325.5" "1155.3" "1195.0" "1222.1" "1052.9" "1430.0" "1229.8" "935.3" "" "" "" "" "" "" "" "" "" "" "674.4" "664.9" "759.1" "532.0" "646.5" "679.8" "619.7" "780.6" "689.9" "935.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3269209104434095274" "False" "High" "IsMasterProtein" "P40227" "T-complex protein 1 subunit zeta OS=Homo sapiens OX=9606 GN=CCT6A PE=1 SV=3" "0.000" "False" "58.993" "22" "14" "34" "14" "531" "58.0" "6.68" "88.56" "14" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00118" "908" "ENSG00000146731" "CCT6A" "A6NCD2; hsa:908; P40227; Q3KP28; Q75LP4; Q96S46" "16p11.2 proximal deletion syndrome" "Formation of tubulin folding intermediates by CCT/TriC; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC" "7" "0" "0.979" "0.988" "1.029" "0.981" "0.978" "0.995" "1.015" "0.935" "0.602" "3519.4" "3444.4" "3477.2" "3621.7" "3453.5" "3443.3" "3502.6" "3570.9" "3292.2" "2119.3" "" "" "" "" "" "" "" "" "" "" "1863.5" "1909.7" "1991.4" "1667.9" "1868.5" "1915.3" "2061.4" "1949.2" "1846.9" "2119.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6656401588938308742" "False" "High" "IsMasterProtein" "Q14676" "Mediator of DNA damage checkpoint protein 1 OS=Homo sapiens OX=9606 GN=MDC1 PE=1 SV=3" "0.000" "False" "58.937" "9" "14" "18" "14" "2089" "226.5" "5.47" "55.81" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00498, Pf16589, Pf16770" "9656" "ENSG00000137337; ENSG00000206481; ENSG00000224587; ENSG00000225589; ENSG00000228575; ENSG00000231135; ENSG00000234012; ENSG00000237095" "MDC1" "A2AB04; A2BF04; A2RRA8; A7YY86; B0S8A2; hsa:9656; Q0EFC2; Q14676; Q2L6H7; Q2TAZ4; Q5JP55; Q5JP56; Q5ST83; Q68CQ3; Q86Z06; Q96QC2" "ATM signaling in development and disease ; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome" "Nonhomologous End-Joining (NHEJ); SUMOylation of DNA damage response and repair proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; TP53 Regulates Transcription of DNA Repair Genes; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint" "9" "0" "1.071" "1.097" "1.267" "1.386" "1.146" "1.518" "1.517" "1.404" "1.209" "412.4" "441.7" "452.3" "522.5" "571.8" "472.8" "626.1" "625.5" "579.1" "498.5" "" "" "" "" "" "" "" "" "" "" "218.4" "244.9" "259.0" "240.7" "309.4" "263.0" "368.5" "341.4" "324.8" "498.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4010508153477037857" "False" "High" "IsMasterProtein" "Q14103" "Heterogeneous nuclear ribonucleoprotein D0 OS=Homo sapiens OX=9606 GN=HNRNPD PE=1 SV=1" "0.000" "False" "58.837" "34" "13" "47" "10" "355" "38.4" "7.81" "121.05" "13" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08143" "3184" "ENSG00000138668" "HNRNPD" "A8K9J2; hsa:3184; P07029; Q01858; Q14100; Q14101; Q14102; Q14103; Q4W5A1; Q9UCE8; Q9UCE9" "mRNA processing" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "3" "3" "0.962" "1.030" "1.012" "0.965" "0.957" "0.971" "1.018" "0.945" "0.517" "2997.5" "2882.2" "3087.7" "3032.1" "2892.2" "2868.8" "2910.4" "3050.2" "2832.7" "1548.4" "" "" "" "" "" "" "" "" "" "" "1587.2" "1598.0" "1768.3" "1396.4" "1564.8" "1595.8" "1712.8" "1665.0" "1589.1" "1548.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6099589946817253427" "False" "High" "IsMasterProtein" "Q7Z417" "FMR1-interacting protein NUFIP2 OS=Homo sapiens OX=9606 GN=NUFIP2 PE=1 SV=1" "0.000" "False" "58.813" "15" "7" "11" "7" "695" "76.1" "8.70" "38.09" "7" "" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf15293" "57532" "ENSG00000108256" "NUFIP2" "A1L3A6; A1L3A7; hsa:57532; Q7Z417; Q9P2M5" "" "" "0" "0" "1.025" "1.062" "1.056" "1.153" "1.112" "1.223" "1.331" "1.319" "0.703" "821.5" "842.2" "872.1" "867.2" "947.2" "913.2" "1004.4" "1093.3" "1083.8" "577.8" "" "" "" "" "" "" "" "" "" "" "435.0" "466.9" "499.4" "399.4" "512.5" "507.9" "591.1" "596.8" "608.0" "577.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8479889696518381262" "False" "High" "IsMasterProtein" "P37802" "Transgelin-2 OS=Homo sapiens OX=9606 GN=TAGLN2 PE=1 SV=3" "0.000" "False" "58.402" "56" "11" "43" "11" "199" "22.4" "8.25" "106.39" "11" "cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton" "cytoskeletal activity" "Pf00307, Pf00402" "8407" "ENSG00000158710" "TAGLN2" "E9KL39; hsa:8407; P37802; Q5JRQ6; Q5JRQ7; Q6FGI1; Q9BUH5; Q9H4P0" "" "Platelet degranulation" "1" "0" "1.015" "1.039" "1.050" "1.025" "0.968" "1.020" "1.037" "1.042" "1.019" "2858.0" "2901.2" "2968.1" "3001.0" "2930.5" "2767.8" "2916.5" "2962.5" "2977.4" "2911.3" "" "" "" "" "" "" "" "" "" "" "1513.3" "1608.5" "1699.8" "1382.0" "1585.5" "1539.6" "1716.5" "1617.1" "1670.3" "2911.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4773020118127395212" "False" "High" "IsMasterProtein" "P30740" "Leukocyte elastase inhibitor OS=Homo sapiens OX=9606 GN=SERPINB1 PE=1 SV=1" "0.000" "False" "58.205" "33" "11" "20" "11" "379" "42.7" "6.28" "55.86" "11" "cell cycle OR cell proliferation;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf00079" "1992" "ENSG00000021355" "SERPINB1" "A8K5L2; B4DNT0; hsa:1992; P30740; Q53FB9; Q5W0E1; Q9UDF8" "Vitamin D receptor pathway" "Neutrophil degranulation" "2" "0" "0.950" "0.944" "0.881" "0.957" "1.015" "0.933" "0.981" "0.975" "0.646" "2204.0" "2094.3" "2081.3" "1941.1" "2110.0" "2237.8" "2055.3" "2162.7" "2147.8" "1424.6" "" "" "" "" "" "" "" "" "" "" "1167.0" "1161.2" "1191.9" "893.9" "1141.6" "1244.7" "1209.6" "1180.5" "1204.8" "1424.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1205545228874989707" "False" "High" "IsMasterProtein" "Q92900" "Regulator of nonsense transcripts 1 OS=Homo sapiens OX=9606 GN=UPF1 PE=1 SV=2" "0.000" "False" "58.079" "14" "16" "23" "16" "1129" "124.3" "6.61" "65.17" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09416, Pf13086, Pf13087, Pf18141" "5976" "ENSG00000005007" "UPF1" "hsa:5976; O00239; O43343; Q86Z25; Q92842; Q92900" "Pathophysiological roles of DUX4 in FSHD1" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "3" "0" "1.080" "0.995" "0.984" "1.092" "1.116" "0.941" "0.934" "0.937" "0.842" "1831.8" "1978.0" "1821.9" "1802.2" "2001.0" "2043.5" "1723.6" "1710.5" "1715.5" "1542.1" "" "" "" "" "" "" "" "" "" "" "969.9" "1096.7" "1043.4" "830.0" "1082.6" "1136.7" "1014.4" "933.7" "962.3" "1542.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5232006824815591416" "False" "High" "IsMasterProtein" "P14317" "Hematopoietic lineage cell-specific protein OS=Homo sapiens OX=9606 GN=HCLS1 PE=1 SV=3" "0.000" "False" "57.972" "29" "13" "30" "13" "486" "54.0" "4.81" "83.21" "13" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf02218" "3059" "ENSG00000180353" "HCLS1" "B4DQ69; hsa:3059; P14317; Q53Y93; Q6IBK9; Q9UDK0" "Pathogenic Escherichia coli infection; B cell receptor signaling pathway; TYROBP causal network in microglia" "" "3" "0" "0.999" "1.060" "0.948" "0.973" "1.003" "0.922" "0.962" "0.988" "0.615" "2045.2" "2043.1" "2168.3" "1938.0" "1990.6" "2050.9" "1884.9" "1968.0" "2021.5" "1257.2" "" "" "" "" "" "" "" "" "" "" "1082.9" "1132.7" "1241.8" "892.5" "1077.0" "1140.8" "1109.3" "1074.2" "1134.0" "1257.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1088137077242897803" "False" "High" "IsMasterProtein" "P51659" "Peroxisomal multifunctional enzyme type 2 OS=Homo sapiens OX=9606 GN=HSD17B4 PE=1 SV=3" "0.000" "False" "57.970" "13" "9" "16" "9" "736" "79.6" "8.84" "50.45" "9" "other metabolic processes;developmental processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf00106, Pf01575, Pf02036" "3295" "ENSG00000133835" "HSD17B4" "B4DNV1; B4DVS5; E9PB82; F5HE57; hsa:3295; P51659" "Androgen receptor network in prostate cancer; Steroid biosynthesis; Disorders of bile acid synthesis and biliary transport; Primary ovarian insufficiency" "TYSND1 cleaves peroxisomal proteins; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of pristanoyl-CoA; Beta-oxidation of very long chain fatty acids" "10" "0" "1.012" "1.024" "0.969" "1.020" "1.067" "0.918" "0.948" "0.918" "0.582" "1846.4" "1869.1" "1890.3" "1789.0" "1882.9" "1970.3" "1695.1" "1749.6" "1695.7" "1073.8" "" "" "" "" "" "" "" "" "" "" "977.7" "1036.3" "1082.6" "823.9" "1018.7" "1096.0" "997.6" "955.0" "951.3" "1073.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1437948072660631583" "False" "High" "IsMasterProtein" "O60664" "Perilipin-3 OS=Homo sapiens OX=9606 GN=PLIN3 PE=1 SV=3" "0.000" "False" "57.916" "26" "10" "18" "10" "434" "47.0" "5.44" "56.92" "10" "cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf03036" "10226" "ENSG00000105355" "PLIN3" "A8K4Y9; hsa:10226; K7EQF4; O60664; Q53G77; Q9BS03; Q9UBD7; Q9UP92" "" "Late endosomal microautophagy; Triglyceride catabolism; Retrograde transport at the Trans-Golgi-Network; RHOBTB3 ATPase cycle; Lipophagy; Chaperone Mediated Autophagy" "6" "0" "0.981" "1.002" "0.884" "0.978" "1.043" "0.878" "0.973" "1.003" "0.720" "2721.1" "2669.8" "2726.8" "2406.4" "2660.7" "2839.0" "2389.8" "2648.7" "2728.7" "1959.6" "" "" "" "" "" "" "" "" "" "" "1440.8" "1480.2" "1561.6" "1108.2" "1439.5" "1579.2" "1406.5" "1445.8" "1530.7" "1959.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "626595147841982495" "False" "High" "IsMasterProtein" "Q92835" "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 OS=Homo sapiens OX=9606 GN=INPP5D PE=1 SV=2" "0.000" "False" "57.669" "13" "14" "16" "13" "1189" "133.2" "7.59" "47.10" "14" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "other molecular function" "Pf00017" "3635" "ENSG00000168918; ENSG00000281614" "INPP5D" "hsa:3635; O00145; Q13544; Q13545; Q6P5A4; Q92656; Q92835; Q9UE80" "B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; IL-4 signaling pathway; EGF/EGFR signaling pathway; Netrin-UNC5B signaling pathway; 5q35 copy number variation" "Downstream TCR signaling; Synthesis of PIPs at the plasma membrane; Interleukin receptor SHC signaling; Synthesis of IP3 and IP4 in the cytosol; Signaling by CSF1 (M-CSF) in myeloid cells; PECAM1 interactions" "13" "0" "1.112" "1.023" "1.263" "1.114" "1.113" "1.176" "0.562" "1.124" "8.432" "701.4" "779.7" "717.6" "885.7" "781.4" "780.4" "824.9" "394.4" "788.7" "5914.0" "" "" "" "" "" "" "" "" "" "" "371.4" "432.3" "410.9" "407.9" "422.8" "434.1" "485.5" "215.3" "442.4" "5914.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5372925708799750934" "False" "High" "IsMasterProtein" "Q15046" "Lysine--tRNA ligase OS=Homo sapiens OX=9606 GN=KARS1 PE=1 SV=3" "0.000" "False" "57.466" "26" "15" "28" "15" "597" "68.0" "6.35" "65.93" "15" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00152, Pf01336" "3735" "ENSG00000065427" "KARS1" "A8MSK1; D3DUK4; hsa:3735; O14946; Q15046; Q96J25; Q9HB23" "" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation" "3" "0" "1.005" "1.030" "1.047" "1.001" "0.993" "0.919" "0.953" "0.867" "0.886" "2145.9" "2157.4" "2210.5" "2247.5" "2149.0" "2130.9" "1972.4" "2044.1" "1861.2" "1901.3" "" "" "" "" "" "" "" "" "" "" "1136.3" "1196.1" "1265.9" "1035.1" "1162.7" "1185.3" "1160.8" "1115.8" "1044.1" "1901.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6826541305752528518" "False" "High" "IsMasterProtein" "P23381" "Tryptophan--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=WARS1 PE=1 SV=2" "0.000" "False" "57.428" "26" "13" "33" "13" "471" "53.1" "6.23" "79.43" "13" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00458, Pf00579" "7453" "ENSG00000140105" "WARS1" "A6NGN1; A6NID3; hsa:7453; P23381; P78535; Q502Y0; Q53XB6; Q9UDI5; Q9UDL3" "Photodynamic therapy-induced unfolded protein response; Amino acid metabolism" "Cytosolic tRNA aminoacylation" "3" "0" "0.968" "1.034" "0.900" "1.014" "1.045" "0.912" "1.005" "1.004" "0.532" "1945.9" "1883.3" "2012.1" "1751.9" "1973.3" "2032.8" "1774.1" "1956.0" "1953.7" "1035.7" "" "" "" "" "" "" "" "" "" "" "1030.3" "1044.2" "1152.3" "806.8" "1067.6" "1130.7" "1044.1" "1067.7" "1096.0" "1035.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4630001761870027344" "False" "High" "IsMasterProtein" "P34897" "Serine hydroxymethyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=SHMT2 PE=1 SV=3" "0.000" "False" "57.322" "30" "16" "57" "15" "504" "56.0" "8.53" "112.78" "16" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00464" "6472" "ENSG00000182199" "SHMT2" "B7Z9F1; E7EQ19; E7EU43; hsa:6472; O00740; P34897; Q8N1A5" "Glycine metabolism; Vitamin B12 metabolism; Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling; Metabolic Epileptic Disorders" "RHOG GTPase cycle; Mitochondrial protein degradation; Metabolism of folate and pterines" "13" "0" "1.029" "1.017" "0.966" "0.995" "1.007" "0.974" "1.001" "0.976" "0.530" "3563.5" "3668.3" "3625.3" "3442.5" "3547.1" "3586.9" "3471.4" "3567.1" "3476.2" "1887.8" "" "" "" "" "" "" "" "" "" "" "1886.9" "2033.8" "2076.2" "1585.4" "1919.1" "1995.2" "2043.0" "1947.1" "1950.1" "1887.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9171365705039643338" "False" "High" "IsMasterProtein" "P45974" "Ubiquitin carboxyl-terminal hydrolase 5 OS=Homo sapiens OX=9606 GN=USP5 PE=1 SV=2" "0.000" "False" "57.198" "17" "13" "21" "13" "858" "95.7" "5.03" "53.27" "13" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf00443, Pf00627, Pf02148, Pf17807" "8078" "ENSG00000111667" "USP5" "D3DUS7; D3DUS8; hsa:8078; P45974; Q96J22" "IL-18 signaling pathway" "Ub-specific processing proteases; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "3" "0" "1.077" "0.986" "1.021" "1.039" "1.044" "1.010" "0.980" "0.980" "0.911" "1609.0" "1732.6" "1586.1" "1643.2" "1671.7" "1680.4" "1625.5" "1577.5" "1576.6" "1466.3" "" "" "" "" "" "" "" "" "" "" "852.0" "960.6" "908.4" "756.7" "904.5" "934.7" "956.6" "861.1" "884.4" "1466.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3283541064302857350" "False" "High" "IsMasterProtein" "O75533" "Splicing factor 3B subunit 1 OS=Homo sapiens OX=9606 GN=SF3B1 PE=1 SV=3" "0.000" "False" "57.122" "14" "15" "19" "15" "1304" "145.7" "7.09" "55.46" "15" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf08920" "23451" "ENSG00000115524" "SF3B1" "E9PCH3; hsa:23451; O75533" "mRNA processing; 10q11.21q11.23 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "5" "0" "1.013" "0.998" "1.025" "1.041" "0.989" "1.125" "1.117" "1.152" "1.166" "1717.4" "1739.7" "1713.6" "1760.8" "1787.6" "1698.1" "1932.7" "1917.5" "1977.9" "2001.9" "" "" "" "" "" "" "" "" "" "" "909.4" "964.5" "981.3" "810.9" "967.1" "944.6" "1137.4" "1046.7" "1109.5" "2001.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2887047081584333281" "False" "High" "IsMasterProtein" "P54652" "Heat shock-related 70 kDa protein 2 OS=Homo sapiens OX=9606 GN=HSPA2 PE=1 SV=1" "0.000" "False" "56.929" "14" "11" "51" "1" "639" "70.0" "5.74" "149.70" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00012" "3306" "ENSG00000126803" "HSPA2" "hsa:3306; P54652; Q15508; Q53XM3; Q9UE78" "Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Measles virus infection; 7q11.23 copy number variation syndrome; Urotensin-II-mediated signaling pathway" "Regulation of HSF1-mediated heat shock response; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Meiotic synapsis; PKR-mediated signaling; Attenuation phase" "10" "0" "1.333" "1.145" "1.028" "1.638" "1.147" "1.194" "1.096" "1.040" "1.216" "259.5" "345.9" "297.1" "266.8" "425.0" "297.5" "309.7" "284.3" "269.9" "315.5" "" "" "" "" "" "" "" "" "" "" "137.4" "191.8" "170.1" "122.9" "229.9" "165.5" "182.3" "155.2" "151.4" "315.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "964900113043376779" "False" "High" "IsMasterProtein" "Q9Y265" "RuvB-like 1 OS=Homo sapiens OX=9606 GN=RUVBL1 PE=1 SV=1" "0.000" "False" "56.772" "27" "11" "17" "11" "456" "50.2" "6.42" "49.67" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf06068, Pf17856" "8607" "ENSG00000175792" "RUVBL1" "B2R5S0; hsa:8607; P82276; Q1KMR0; Q53HK5; Q53HL7; Q53Y27; Q9BSX9; Q9Y265" "Gastric cancer network 1; lncRNA in canonical Wnt signaling and colorectal cancer" "UCH proteinases; Ub-specific processing proteases; Deposition of new CENPA-containing nucleosomes at the centromere; Formation of the beta-catenin:TCF transactivating complex; Telomere Extension By Telomerase; HATs acetylate histones; DNA Damage Recognition in GG-NER" "9" "0" "1.039" "1.045" "1.029" "1.049" "1.033" "1.060" "1.074" "1.029" "0.848" "1236.6" "1285.4" "1292.4" "1272.2" "1296.7" "1277.4" "1311.1" "1328.5" "1272.3" "1048.8" "" "" "" "" "" "" "" "" "" "" "654.8" "712.7" "740.2" "585.9" "701.6" "710.6" "771.6" "725.2" "713.8" "1048.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1477701677307109055" "False" "High" "IsMasterProtein" "P27694" "Replication protein A 70 kDa DNA-binding subunit OS=Homo sapiens OX=9606 GN=RPA1 PE=1 SV=2" "0.000" "False" "56.694" "25" "15" "21" "15" "616" "68.1" "7.21" "53.35" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01336, Pf04057, Pf08646, Pf16900" "6117" "ENSG00000132383" "RPA1" "A8K0Y9; hsa:6117; P27694; Q59ES9" "Homologous recombination; Retinoblastoma gene in cancer; G1 to S cell cycle control; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "SUMOylation of DNA damage response and repair proteins; Fanconi Anemia Pathway; Regulation of HSF1-mediated heat shock response; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Meiotic recombination; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; HSF1 activation; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "38" "0" "0.984" "0.948" "1.265" "1.292" "1.299" "1.530" "1.573" "1.485" "1.500" "1652.9" "1625.7" "1567.7" "2090.7" "2136.3" "2146.6" "2529.0" "2600.7" "2454.2" "2480.1" "" "" "" "" "" "" "" "" "" "" "875.2" "901.3" "897.8" "962.8" "1155.8" "1194.1" "1488.4" "1419.6" "1376.8" "2480.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8106811875095759613" "False" "High" "IsMasterProtein" "P06454" "Prothymosin alpha OS=Homo sapiens OX=9606 GN=PTMA PE=1 SV=2" "0.000" "False" "56.354" "23" "6" "39" "6" "111" "12.2" "3.78" "111.46" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf03247" "5757" "ENSG00000187514" "PTMA" "hsa:5757; P06454; Q15249; Q15592" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.869" "1.066" "1.070" "0.782" "0.845" "0.719" "0.781" "0.738" "0.435" "4376.9" "3803.8" "4664.2" "4684.1" "3421.7" "3697.6" "3146.5" "3420.4" "3228.4" "1903.7" "" "" "" "" "" "" "" "" "" "" "2317.6" "2108.9" "2671.2" "2157.2" "1851.3" "2056.8" "1851.8" "1867.1" "1811.0" "1903.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3910954529377130988" "False" "High" "IsMasterProtein" "Q9UPN3" "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 OS=Homo sapiens OX=9606 GN=MACF1 PE=1 SV=4" "0.000" "False" "56.305" "3" "21" "22" "21" "7388" "837.8" "5.39" "52.77" "21" "cell-cell signaling;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf00681, Pf02187, Pf13499, Pf17902, Pf18373, Pf21019, Pf21020, Pf21097" "23499" "ENSG00000127603" "MACF1" "B1ALC5; E9PJT0; hsa:23499; O75053; Q5VW20; Q8WXY1; Q8WXY2; Q96PK2; Q9H540; Q9UKP0; Q9ULG9; Q9UPN3" "Mesodermal commitment pathway; Mesodermal commitment pathway" "" "2" "0" "1.020" "1.032" "1.156" "1.064" "1.140" "1.321" "1.201" "1.321" "2.870" "993.6" "1013.8" "1025.0" "1149.0" "1057.4" "1132.5" "1312.8" "1192.9" "1312.7" "2852.0" "" "" "" "" "" "" "" "" "" "" "526.1" "562.1" "587.0" "529.1" "572.1" "630.0" "772.6" "651.2" "736.4" "2852.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5468069501493151827" "False" "High" "IsMasterProtein" "P37837" "Transaldolase OS=Homo sapiens OX=9606 GN=TALDO1 PE=1 SV=2" "0.000" "False" "56.204" "27" "9" "23" "9" "337" "37.5" "6.81" "63.08" "9" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00923" "6888" "ENSG00000177156" "TALDO1" "B2R8M2; hsa:6888; O00751; P37837; Q8WV32; Q8WZ45" "Pentose phosphate metabolism; Cori cycle; Metabolic reprogramming in colon cancer" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate; TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P; TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P" "9" "0" "0.941" "0.934" "0.927" "0.948" "0.967" "0.977" "0.942" "0.983" "0.893" "3092.6" "2911.6" "2887.2" "2867.8" "2933.3" "2989.1" "3020.0" "2913.7" "3039.6" "2762.1" "" "" "" "" "" "" "" "" "" "" "1637.5" "1614.3" "1653.5" "1320.7" "1587.0" "1662.7" "1777.4" "1590.5" "1705.2" "2762.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4900440247780228765" "False" "High" "IsMasterProtein" "Q13616" "Cullin-1 OS=Homo sapiens OX=9606 GN=CUL1 PE=1 SV=2" "0.000" "False" "55.952" "19" "15" "23" "15" "776" "89.6" "8.00" "61.47" "15" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8454" "ENSG00000055130" "CUL1" "D3DWG3; hsa:8454; O60719; Q08AL6; Q13616; Q8IYW1" "Cell cycle; TNF-alpha signaling pathway; Parkin-ubiquitin proteasomal system pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; TGF-beta signaling pathway; Pleural mesothelioma; Notch signaling pathway" "Circadian Clock; Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; SCF-beta-TrCP mediated degradation of Emi1; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Cyclin D associated events in G1; Regulation of BACH1 activity; Regulation of PLK1 Activity at G2/M Transition; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; MAP3K8 (TPL2)-dependent MAPK1/3 activation; NOTCH1 Intracellular Domain Regulates Transcription; Prolactin receptor signaling; Iron uptake and transport; Nuclear events stimulated by ALK signaling in cancer; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling" "41" "0" "0.960" "0.962" "0.954" "0.990" "1.022" "1.006" "1.032" "0.972" "0.595" "2759.5" "2648.9" "2654.8" "2633.4" "2731.7" "2821.4" "2777.3" "2846.9" "2680.8" "1641.5" "" "" "" "" "" "" "" "" "" "" "1461.1" "1468.6" "1520.4" "1212.8" "1478.0" "1569.4" "1634.5" "1554.0" "1503.9" "1641.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "965270540937199853" "False" "High" "IsMasterProtein" "Q14151" "Scaffold attachment factor B2 OS=Homo sapiens OX=9606 GN=SAFB2 PE=1 SV=1" "0.000" "False" "55.919" "15" "15" "21" "10" "953" "107.4" "6.16" "55.72" "15" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf02037" "9667" "ENSG00000130254" "SAFB2" "B4DKG3; hsa:9667; Q14151; Q8TB13" "" "" "0" "0" "0.922" "0.967" "1.135" "1.135" "1.071" "1.435" "1.458" "1.497" "0.662" "2326.1" "2145.5" "2250.5" "2639.0" "2640.4" "2490.9" "3337.6" "3392.6" "3482.1" "1538.8" "" "" "" "" "" "" "" "" "" "" "1231.7" "1189.5" "1288.8" "1215.4" "1428.5" "1385.6" "1964.3" "1851.9" "1953.4" "1538.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2770447616449315305" "False" "High" "IsMasterProtein" "Q9Y678" "Coatomer subunit gamma-1 OS=Homo sapiens OX=9606 GN=COPG1 PE=1 SV=1" "0.000" "False" "55.754" "14" "12" "18" "12" "874" "97.7" "5.47" "59.21" "12" "transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf01602, Pf08752, Pf16381" "22820" "ENSG00000181789" "COPG1" "A8K6M8; B3KMF6; hsa:22820; Q54AC4; Q9Y678" "VEGFA-VEGFR2 signaling" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "3" "0" "1.015" "1.043" "0.959" "1.012" "1.005" "0.978" "0.983" "0.974" "1.172" "2289.0" "2323.1" "2387.1" "2194.8" "2317.0" "2300.8" "2239.4" "2250.1" "2230.2" "2682.1" "" "" "" "" "" "" "" "" "" "" "1212.0" "1288.0" "1367.1" "1010.8" "1253.6" "1279.8" "1317.9" "1228.2" "1251.1" "2682.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6124389197736880790" "False" "High" "IsMasterProtein" "P40925" "Malate dehydrogenase, cytoplasmic OS=Homo sapiens OX=9606 GN=MDH1 PE=1 SV=4" "0.000" "False" "55.663" "36" "14" "29" "14" "334" "36.4" "7.36" "80.89" "14" "other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00056, Pf02866" "4190" "ENSG00000014641" "MDH1" "B2R5V5; B4DUN2; B7Z3I7; F5H098; hsa:4190; P40925; Q6I9V0" "Sterol regulatory element-binding proteins (SREBP) signaling; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Clear cell renal cell carcinoma pathways; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; TCA cycle in senescence; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; HDAC6 interactions in the central nervous system" "Gluconeogenesis" "10" "0" "0.931" "0.942" "0.875" "0.961" "1.017" "0.941" "0.983" "0.917" "0.499" "3591.4" "3343.1" "3384.7" "3143.0" "3449.5" "3653.6" "3380.2" "3530.0" "3294.0" "1791.5" "" "" "" "" "" "" "" "" "" "" "1901.6" "1853.5" "1938.4" "1447.5" "1866.3" "2032.3" "1989.3" "1926.9" "1847.8" "1791.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3405603430523799899" "False" "High" "IsMasterProtein" "P52888" "Thimet oligopeptidase OS=Homo sapiens OX=9606 GN=THOP1 PE=1 SV=2" "0.000" "False" "55.564" "20" "15" "32" "15" "689" "78.8" "6.05" "81.47" "15" "protein metabolism;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf01432" "7064" "ENSG00000172009" "THOP1" "B3KSE2; hsa:7064; P52888; Q9UCB3" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.930" "0.972" "0.932" "0.962" "0.940" "0.951" "1.003" "0.974" "0.534" "3392.0" "3155.2" "3297.1" "3162.7" "3263.7" "3188.6" "3225.6" "3400.8" "3304.3" "1812.0" "" "" "" "" "" "" "" "" "" "" "1796.1" "1749.3" "1888.2" "1456.5" "1765.8" "1773.6" "1898.3" "1856.3" "1853.6" "1812.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3259999118554299265" "False" "High" "IsMasterProtein" "Q16181" "Septin-7 OS=Homo sapiens OX=9606 GN=SEPTIN7 PE=1 SV=2" "0.000" "False" "55.442" "29" "12" "36" "11" "437" "50.6" "8.63" "89.73" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00735" "989" "ENSG00000122545" "SEPTIN7" "hsa:989; Q16181; Q52M76; Q6NX50" "" "MAPK6/MAPK4 signaling" "1" "1" "1.026" "0.977" "1.041" "1.000" "0.996" "1.034" "1.014" "0.977" "0.590" "2832.3" "2905.5" "2766.2" "2948.1" "2831.5" "2822.0" "2927.9" "2872.6" "2767.4" "1670.2" "" "" "" "" "" "" "" "" "" "" "1499.7" "1610.9" "1584.2" "1357.7" "1531.9" "1569.7" "1723.2" "1568.0" "1552.4" "1670.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2426861074950700078" "False" "High" "IsMasterProtein" "P22314" "Ubiquitin-like modifier-activating enzyme 1 OS=Homo sapiens OX=9606 GN=UBA1 PE=1 SV=3" "0.000" "False" "55.430" "13" "12" "19" "12" "1058" "117.8" "5.76" "50.87" "12" "protein metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00899, Pf09358, Pf10585, Pf16190, Pf16191" "7317" "ENSG00000130985" "UBA1" "hsa:7317; P22314; Q5JRR8; Q96E13" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "5" "0" "1.043" "1.081" "1.213" "1.058" "1.001" "1.166" "0.766" "1.124" "5.827" "372.5" "388.6" "402.6" "452.0" "394.1" "372.8" "434.4" "285.4" "418.6" "2170.6" "" "" "" "" "" "" "" "" "" "" "197.2" "215.4" "230.6" "208.2" "213.2" "207.4" "255.7" "155.8" "234.8" "2170.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8717421015690566095" "False" "High" "IsMasterProtein" "Q9NQR4" "Omega-amidase NIT2 OS=Homo sapiens OX=9606 GN=NIT2 PE=1 SV=1" "0.000" "False" "55.427" "37" "10" "22" "10" "276" "30.6" "7.21" "61.08" "10" "other metabolic processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00795" "56954" "ENSG00000114021" "NIT2" "B2R9A3; D3DN47; hsa:56954; Q8WUF0; Q9NQR4" "" "Neutrophil degranulation" "1" "0" "0.985" "1.026" "0.949" "0.854" "0.971" "0.873" "1.028" "0.951" "0.578" "2881.8" "2837.9" "2957.4" "2735.9" "2460.7" "2797.8" "2515.5" "2961.6" "2741.8" "1665.0" "" "" "" "" "" "" "" "" "" "" "1525.9" "1573.4" "1693.7" "1260.0" "1331.3" "1556.3" "1480.4" "1616.6" "1538.1" "1665.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1882334441137329574" "False" "High" "IsMasterProtein" "Q9BUJ2" "Heterogeneous nuclear ribonucleoprotein U-like protein 1 OS=Homo sapiens OX=9606 GN=HNRNPUL1 PE=1 SV=2" "0.000" "False" "55.290" "17" "15" "22" "15" "856" "95.7" "6.92" "55.88" "15" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00622, Pf02037, Pf13671" "11100" "ENSG00000105323" "HNRNPUL1" "B3KMW7; hsa:11100; O76022; Q6ZSZ0; Q7L8P4; Q8N6Z4; Q96G37; Q9BUJ2; Q9HAL3; Q9UG75" "" "" "0" "0" "0.941" "1.033" "0.928" "1.086" "1.103" "1.416" "1.501" "1.564" "2.196" "1454.3" "1368.9" "1502.4" "1349.5" "1579.6" "1604.8" "2059.5" "2182.3" "2274.1" "3193.4" "" "" "" "" "" "" "" "" "" "" "770.0" "758.9" "860.4" "621.5" "854.6" "892.6" "1212.1" "1191.2" "1275.7" "3193.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1936662048644361405" "False" "High" "IsMasterProtein" "P55060" "Exportin-2 OS=Homo sapiens OX=9606 GN=CSE1L PE=1 SV=3" "0.000" "False" "55.279" "13" "13" "17" "13" "971" "110.3" "5.77" "48.52" "13" "transport" "cytosol;nucleus;other cell component" "other molecular function" "Pf03378, Pf03810, Pf08506" "1434" "ENSG00000124207" "CSE1L" "A3RLL6; B2R5T4; E1P5Y0; F8W904; hsa:1434; O75432; P55060; Q32M40; Q9H5B7; Q9NTS0; Q9UP98; Q9UP99; Q9UPA0" "" "" "0" "0" "1.086" "0.950" "1.238" "1.032" "1.041" "1.097" "0.856" "0.996" "3.453" "1124.5" "1220.9" "1068.4" "1391.9" "1160.2" "1170.3" "1233.5" "962.5" "1120.2" "3882.8" "" "" "" "" "" "" "" "" "" "" "595.4" "676.9" "611.9" "641.0" "627.7" "651.0" "726.0" "525.4" "628.4" "3882.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8320203953169685442" "False" "High" "IsMasterProtein" "Q9NZL9" "Methionine adenosyltransferase 2 subunit beta OS=Homo sapiens OX=9606 GN=MAT2B PE=1 SV=1" "0.000" "False" "55.269" "29" "10" "20" "10" "334" "37.5" "7.36" "59.99" "10" "other metabolic processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04321" "27430" "ENSG00000038274" "MAT2B" "B2R5Y6; hsa:27430; Q1WAI7; Q27J92; Q3LIE8; Q567T7; Q6NYC7; Q9BS89; Q9H3E1; Q9NZL9; Q9UJ54" "Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; Spina bifida; Methylation pathways" "Ub-specific processing proteases; Methylation" "8" "0" "0.976" "0.934" "0.998" "1.014" "1.057" "1.025" "1.009" "1.039" "0.598" "808.3" "788.8" "754.8" "806.7" "819.7" "854.2" "828.3" "815.3" "839.6" "483.2" "" "" "" "" "" "" "" "" "" "" "428.0" "437.3" "432.2" "371.5" "443.5" "475.1" "487.5" "445.0" "471.0" "483.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4535556334998408323" "False" "High" "IsMasterProtein" "P49411" "Elongation factor Tu, mitochondrial OS=Homo sapiens OX=9606 GN=TUFM PE=1 SV=3" "0.000" "False" "55.067" "28" "12" "21" "12" "455" "49.8" "7.61" "59.40" "12" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "7284" "ENSG00000178952" "TUFM" "hsa:7284; O15276; P49411" "16p11.2 distal deletion syndrome" "Mitochondrial translation elongation; SARS-CoV-2 modulates autophagy" "3" "0" "0.958" "0.912" "0.957" "0.936" "0.960" "0.849" "0.806" "0.808" "1.039" "2215.0" "2122.1" "2020.8" "2120.0" "2073.9" "2126.9" "1879.7" "1785.5" "1789.9" "2301.8" "" "" "" "" "" "" "" "" "" "" "1172.9" "1176.6" "1157.3" "976.3" "1122.1" "1183.1" "1106.3" "974.6" "1004.1" "2301.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3509050462547548554" "False" "High" "IsMasterProtein" "Q04917" "14-3-3 protein eta OS=Homo sapiens OX=9606 GN=YWHAH PE=1 SV=4" "0.000" "False" "54.980" "54" "13" "49" "8" "246" "28.2" "4.84" "118.28" "13" "other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00244" "7533" "ENSG00000128245" "YWHAH" "hsa:7533; Q04917" "Cell cycle; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria" "11" "0" "1.021" "0.968" "0.842" "0.982" "1.021" "0.907" "0.987" "1.110" "0.747" "1277.8" "1304.3" "1236.3" "1076.5" "1254.5" "1305.0" "1158.7" "1261.1" "1417.9" "954.2" "" "" "" "" "" "" "" "" "" "" "676.6" "723.2" "708.0" "495.8" "678.7" "725.9" "682.0" "688.4" "795.4" "954.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3588526575422441763" "False" "High" "IsMasterProtein" "P42285" "Exosome RNA helicase MTR4 OS=Homo sapiens OX=9606 GN=MTREX PE=1 SV=3" "0.000" "False" "54.871" "13" "16" "24" "16" "1042" "117.7" "6.52" "66.84" "16" "RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf08148, Pf13234, Pf21408" "23517" "ENSG00000039123" "MTREX" "hsa:23517; P42285; Q2M386; Q6MZZ8; Q6P170; Q8N5R0; Q8TAG2" "" "mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol" "2" "0" "0.979" "0.955" "0.949" "0.960" "0.995" "0.945" "0.977" "0.983" "0.910" "2771.0" "2713.6" "2645.2" "2628.6" "2659.4" "2758.1" "2619.2" "2706.9" "2725.2" "2520.5" "" "" "" "" "" "" "" "" "" "" "1467.2" "1504.5" "1514.9" "1210.5" "1438.8" "1534.2" "1541.5" "1477.6" "1528.7" "2520.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7904029165854268952" "False" "High" "IsMasterProtein" "P62191" "26S proteasome regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PSMC1 PE=1 SV=1" "0.000" "False" "54.799" "28" "11" "20" "11" "440" "49.2" "6.21" "52.55" "11" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5700" "ENSG00000100764" "PSMC1" "B4DR63; hsa:5700; P49014; P62191; Q03527; Q6IAW0; Q6NW36; Q96AZ3" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "64" "0" "0.969" "1.016" "1.015" "1.013" "1.058" "0.925" "0.894" "0.960" "0.772" "1718.1" "1664.3" "1745.6" "1744.4" "1740.4" "1817.4" "1589.3" "1536.9" "1649.2" "1326.8" "" "" "" "" "" "" "" "" "" "" "909.8" "922.8" "999.7" "803.3" "941.6" "1010.9" "935.4" "838.9" "925.2" "1326.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "114843226561293462" "False" "High" "IsMasterProtein" "P67936" "Tropomyosin alpha-4 chain OS=Homo sapiens OX=9606 GN=TPM4 PE=1 SV=3" "0.000" "False" "54.791" "46" "16" "54" "6" "248" "28.5" "4.69" "131.14" "16" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf00261" "7171" "ENSG00000167460" "TPM4" "hsa:7171; P07226; P67936; Q15659; Q5U0D9; Q9BU85; Q9H8Q3; Q9UCS1; Q9UCS2; Q9UCS3; Q9UCS4" "Striated muscle contraction pathway" "Signaling by ALK fusions and activated point mutants; RHOV GTPase cycle; Smooth Muscle Contraction; Striated Muscle Contraction" "5" "9" "0.987" "1.022" "1.025" "0.963" "0.898" "0.930" "1.026" "0.903" "0.468" "4722.8" "4663.5" "4828.2" "4841.5" "4548.1" "4242.4" "4391.6" "4843.8" "4264.4" "2211.1" "" "" "" "" "" "" "" "" "" "" "2500.7" "2585.6" "2765.1" "2229.7" "2460.7" "2359.8" "2584.6" "2644.0" "2392.2" "2211.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7742249596596208262" "False" "High" "IsMasterProtein" "Q7KZF4" "Staphylococcal nuclease domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SND1 PE=1 SV=1" "0.000" "False" "54.706" "14" "13" "17" "13" "910" "101.9" "7.17" "50.42" "13" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00565, Pf00567" "27044" "ENSG00000197157" "SND1" "hsa:27044; Q13122; Q7KZF4; Q96AG0" "VEGFA-VEGFR2 signaling" "Signaling by BRAF and RAF1 fusions" "2" "0" "1.054" "1.006" "1.185" "1.053" "1.115" "1.085" "0.088" "1.042" "13.672" "495.0" "521.8" "497.9" "586.7" "521.4" "552.0" "537.3" "43.4" "516.0" "6767.7" "" "" "" "" "" "" "" "" "" "" "262.1" "289.3" "285.1" "270.2" "282.1" "307.0" "316.2" "23.7" "289.5" "6767.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4573654140983497752" "False" "High" "IsMasterProtein" "P12004" "Proliferating cell nuclear antigen OS=Homo sapiens OX=9606 GN=PCNA PE=1 SV=1" "0.000" "False" "54.676" "43" "10" "37" "10" "261" "28.8" "4.69" "102.88" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00705, Pf02747" "5111" "ENSG00000132646" "PCNA" "B2R897; D3DW02; hsa:5111; P12004" "Cell cycle; Retinoblastoma gene in cancer; Primary focal segmental glomerulosclerosis (FSGS); Oxidative damage response; EGF/EGFR signaling pathway; G1 to S cell cycle control; DNA replication; Hepatitis B infection; Base excision repair; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; 16p11.2 proximal deletion syndrome; p53 transcriptional gene network; Nucleotide excision repair in xeroderma pigmentosum ; Urotensin-II-mediated signaling pathway; DNA mismatch repair; 10q11.21q11.23 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; NF1 copy number variation syndrome ; Rubinstein-Taybi syndrome 1" "HDR through Homologous Recombination (HRR); E3 ubiquitin ligases ubiquitinate target proteins; SUMOylation of DNA replication proteins; Termination of translesion DNA synthesis; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; G1/S-Specific Transcription; Recognition of DNA damage by PCNA-containing replication complex; Transcription of E2F targets under negative control by DREAM complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "47" "0" "0.953" "0.936" "1.022" "0.994" "0.999" "1.044" "0.974" "0.956" "0.605" "1782.0" "1698.7" "1667.5" "1821.8" "1771.2" "1779.9" "1861.0" "1736.4" "1703.1" "1078.2" "" "" "" "" "" "" "" "" "" "" "943.6" "941.8" "955.0" "839.0" "958.3" "990.1" "1095.2" "947.8" "955.4" "1078.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2337219862284108106" "False" "High" "IsMasterProtein" "Q9Y262" "Eukaryotic translation initiation factor 3 subunit L OS=Homo sapiens OX=9606 GN=EIF3L PE=1 SV=1" "0.000" "False" "54.661" "24" "12" "18" "12" "564" "66.7" "6.34" "53.98" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf10255" "51386" "ENSG00000100129" "EIF3L" "B2RDG6; B4DYB2; G8JLH4; hsa:51386; Q53HQ1; Q53HT4; Q5QTR1; Q5TI15; Q6ICD2; Q9Y262" "" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition" "6" "0" "1.029" "1.007" "1.033" "1.026" "1.061" "0.975" "0.983" "0.991" "0.618" "1596.5" "1642.0" "1608.0" "1648.6" "1638.3" "1694.0" "1556.0" "1569.6" "1582.2" "986.5" "" "" "" "" "" "" "" "" "" "" "845.3" "910.4" "920.9" "759.2" "886.4" "942.3" "915.8" "856.8" "887.6" "986.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6400995593712089390" "False" "High" "IsMasterProtein" "Q9NYU2" "UDP-glucose:glycoprotein glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=UGGT1 PE=1 SV=3" "0.000" "False" "54.445" "9" "15" "25" "15" "1555" "177.1" "5.63" "67.05" "15" "protein metabolism;other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf06427, Pf18400, Pf18401, Pf18402, Pf18403, Pf18404" "56886" "ENSG00000136731" "UGGT1" "hsa:56886; Q53QP2; Q53SL3; Q8IW30; Q9H8I4; Q9NYU2" "IL-18 signaling pathway" "ER Quality Control Compartment (ERQC)" "2" "0" "0.981" "1.028" "0.958" "1.075" "1.044" "0.980" "1.031" "1.031" "0.869" "1700.9" "1668.3" "1747.8" "1628.8" "1828.9" "1775.3" "1667.2" "1754.1" "1753.5" "1478.5" "" "" "" "" "" "" "" "" "" "" "900.6" "924.9" "1001.0" "750.1" "989.5" "987.5" "981.2" "957.5" "983.7" "1478.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7835862942369075388" "False" "High" "IsMasterProtein" "P06753" "Tropomyosin alpha-3 chain OS=Homo sapiens OX=9606 GN=TPM3 PE=1 SV=2" "0.000" "False" "54.430" "32" "14" "52" "4" "285" "32.9" "4.72" "133.83" "14" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf00261" "7170" "ENSG00000143549" "TPM3" "D3DV71; hsa:7170; P06753; P12324; Q2QD06; Q5VU58; Q5VU63; Q5VU66; Q5VU71; Q5VU72; Q8TCG3; Q969Q2; Q9NQH8" "Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Striated muscle contraction pathway; VEGFA-VEGFR2 signaling" "Signaling by ALK fusions and activated point mutants; RHOV GTPase cycle; Smooth Muscle Contraction; Striated Muscle Contraction" "7" "0" "0.950" "0.965" "1.068" "1.000" "0.915" "0.986" "0.993" "0.839" "0.455" "634.8" "603.1" "612.8" "677.9" "634.5" "580.7" "626.1" "630.3" "532.9" "288.6" "" "" "" "" "" "" "" "" "" "" "336.1" "334.4" "350.9" "312.2" "343.3" "323.0" "368.5" "344.0" "298.9" "288.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8574312361860662093" "False" "High" "IsMasterProtein" "Q92620" "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 OS=Homo sapiens OX=9606 GN=DHX38 PE=1 SV=2" "0.000" "False" "54.313" "11" "13" "16" "13" "1227" "140.4" "6.54" "45.92" "13" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "9785" "ENSG00000140829" "DHX38" "B4DVG8; D3DWS7; hsa:9785; O75212; Q92620; Q96HN7" "mRNA processing" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "5" "0" "0.998" "0.911" "1.010" "1.047" "1.004" "0.972" "1.015" "1.050" "0.986" "878.6" "877.0" "800.7" "887.2" "919.4" "881.9" "853.6" "891.3" "922.3" "866.0" "" "" "" "" "" "" "" "" "" "" "465.2" "486.2" "458.6" "408.6" "497.4" "490.6" "502.4" "486.5" "517.4" "866.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2098807042560158640" "False" "High" "IsMasterProtein" "P13489" "Ribonuclease inhibitor OS=Homo sapiens OX=9606 GN=RNH1 PE=1 SV=2" "0.000" "False" "54.277" "21" "9" "17" "9" "461" "49.9" "4.82" "56.22" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf13516, Pf18779" "6050" "ENSG00000023191; ENSG00000276230" "RNH1" "hsa:6050; P13489; Q8IZK8; Q96FD7; Q9BQ80; Q9UDK6" "" "" "0" "0" "1.037" "0.978" "1.111" "1.101" "1.046" "1.107" "1.047" "0.963" "0.728" "1084.8" "1125.3" "1060.4" "1204.8" "1194.0" "1134.2" "1200.9" "1135.9" "1045.1" "789.9" "" "" "" "" "" "" "" "" "" "" "574.4" "623.9" "607.3" "554.9" "646.0" "630.9" "706.8" "620.1" "586.3" "789.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1479790111935506116" "False" "High" "IsMasterProtein" "Q9P258" "Protein RCC2 OS=Homo sapiens OX=9606 GN=RCC2 PE=1 SV=2" "0.000" "False" "54.198" "27" "15" "23" "15" "522" "56.0" "8.78" "67.48" "15" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00415" "55920" "ENSG00000179051; ENSG00000281540" "RCC2" "hsa:55920; Q8IVL9; Q9BSN6; Q9NPV8; Q9P258" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "0.993" "0.966" "0.942" "0.939" "0.964" "0.943" "0.910" "0.903" "0.796" "2793.6" "2774.9" "2699.6" "2632.7" "2623.7" "2692.0" "2634.7" "2540.9" "2522.0" "2224.0" "" "" "" "" "" "" "" "" "" "" "1479.2" "1538.5" "1546.1" "1212.4" "1419.5" "1497.4" "1550.6" "1386.9" "1414.8" "2224.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5122002380756434681" "False" "High" "IsMasterProtein" "Q9Y6E2" "eIF5-mimic protein 1 OS=Homo sapiens OX=9606 GN=BZW2 PE=1 SV=1" "0.000" "False" "54.127" "30" "13" "22" "12" "419" "48.1" "6.68" "64.67" "13" "other biological processes" "other cell component" "" "Pf02020" "28969" "ENSG00000136261" "BZW2" "A4D123; hsa:28969; Q3B779; Q96JW5; Q9H3F7; Q9Y6E2" "" "" "0" "1" "0.987" "0.951" "0.951" "1.013" "1.028" "0.998" "0.949" "0.972" "1.531" "2478.6" "2446.5" "2357.9" "2357.3" "2511.4" "2548.9" "2473.7" "2352.1" "2408.2" "3795.7" "" "" "" "" "" "" "" "" "" "" "1312.4" "1356.4" "1350.3" "1085.6" "1358.7" "1417.8" "1455.8" "1283.9" "1351.0" "3795.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2867565850229162791" "False" "High" "IsMasterProtein" "P12081" "Histidine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=HARS1 PE=1 SV=2" "0.000" "False" "53.962" "23" "13" "23" "9" "509" "57.4" "5.88" "69.34" "13" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00458, Pf03129, Pf13393" "3035" "ENSG00000170445" "HARS1" "B4DHQ1; B4DY73; D6REN6; hsa:3035; J3KNE5; P12081" "Allograft rejection" "Cytosolic tRNA aminoacylation" "2" "3" "0.953" "0.992" "0.935" "1.035" "0.984" "0.881" "0.881" "0.860" "0.621" "2667.4" "2542.7" "2647.3" "2494.2" "2760.9" "2624.6" "2349.3" "2349.0" "2295.0" "1656.5" "" "" "" "" "" "" "" "" "" "" "1412.4" "1409.8" "1516.1" "1148.7" "1493.8" "1459.9" "1382.7" "1282.2" "1287.5" "1656.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3364177795992672609" "False" "High" "IsMasterProtein" "P42765" "3-ketoacyl-CoA thiolase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAA2 PE=1 SV=2" "0.000" "False" "53.646" "31" "11" "22" "11" "397" "41.9" "8.09" "65.57" "11" "cell organization and biogenesis;other metabolic processes;stress response;transport" "mitochondrion" "other molecular function" "Pf00108, Pf02803" "10449" "ENSG00000167315" "ACAA2" "hsa:10449; P42765; Q9BUT6" "Fatty acid biosynthesis" "Mitochondrial Fatty Acid Beta-Oxidation" "2" "0" "0.968" "0.973" "0.946" "0.986" "0.980" "0.940" "1.013" "0.968" "0.479" "1876.3" "1817.1" "1826.0" "1774.3" "1850.4" "1838.6" "1764.0" "1900.7" "1816.0" "898.3" "" "" "" "" "" "" "" "" "" "" "993.5" "1007.5" "1045.7" "817.1" "1001.2" "1022.7" "1038.2" "1037.5" "1018.7" "898.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-199396300438152648" "False" "High" "IsMasterProtein" "P25788" "Proteasome subunit alpha type-3 OS=Homo sapiens OX=9606 GN=PSMA3 PE=1 SV=2" "0.000" "False" "53.635" "36" "11" "28" "11" "255" "28.4" "5.33" "87.93" "11" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf10584" "5684" "ENSG00000100567" "PSMA3" "B2RCK6; hsa:5684; P25788; Q86U83; Q8N1D8; Q9BS70" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; UCH proteinases; Regulation of RUNX3 expression and activity; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "0.930" "0.939" "0.894" "0.955" "0.965" "1.061" "0.958" "0.926" "0.529" "3115.9" "2898.1" "2927.3" "2785.1" "2975.5" "3007.1" "3307.1" "2985.6" "2884.5" "1647.0" "" "" "" "" "" "" "" "" "" "" "1649.9" "1606.8" "1676.4" "1282.6" "1609.8" "1672.7" "1946.3" "1629.7" "1618.2" "1647.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6928651678899214990" "False" "High" "IsMasterProtein" "Q86VM9" "Zinc finger CCCH domain-containing protein 18 OS=Homo sapiens OX=9606 GN=ZC3H18 PE=1 SV=2" "0.000" "False" "53.556" "15" "10" "12" "10" "953" "106.3" "8.32" "47.60" "10" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf18044" "124245" "ENSG00000158545" "ZC3H18" "hsa:124245; Q86VM9; Q96DG4; Q96MP7" "" "" "0" "0" "1.000" "1.078" "1.112" "1.187" "1.045" "1.794" "1.784" "1.776" "0.946" "1270.5" "1270.7" "1369.7" "1412.8" "1507.5" "1327.3" "2279.3" "2266.6" "2256.6" "1201.7" "" "" "" "" "" "" "" "" "" "" "672.7" "704.5" "784.4" "650.6" "815.6" "738.3" "1341.5" "1237.2" "1265.9" "1201.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1447147241946060131" "False" "High" "IsMasterProtein" "P61604" "10 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPE1 PE=1 SV=2" "0.000" "False" "53.382" "70" "10" "48" "10" "102" "10.9" "8.92" "133.16" "10" "protein metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion" "other molecular function" "Pf00166" "3336" "ENSG00000115541" "HSPE1" "hsa:3336; O95421; P61604; Q04984; Q53X54; Q9UDH0" "" "RHOG GTPase cycle" "1" "0" "0.899" "1.006" "0.903" "0.910" "0.844" "0.919" "0.891" "0.882" "0.374" "6914.2" "6215.5" "6953.6" "6244.6" "6292.8" "5833.0" "6351.8" "6163.7" "6098.2" "2588.7" "" "" "" "" "" "" "" "" "" "" "3661.1" "3446.1" "3982.3" "2875.8" "3404.6" "3244.6" "3738.3" "3364.5" "3421.0" "2588.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "338610440228744590" "False" "High" "IsMasterProtein" "Q13620" "Cullin-4B OS=Homo sapiens OX=9606 GN=CUL4B PE=1 SV=4" "0.000" "False" "53.303" "14" "14" "25" "8" "913" "103.9" "7.37" "67.55" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8450" "ENSG00000158290" "CUL4B" "B1APK5; B3KVX4; B7Z5K8; hsa:8450; Q13620; Q6PIE4; Q6UP07; Q7Z673; Q9BY37; Q9UEB7; Q9UED7" "Mesodermal commitment pathway; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; Neddylation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER" "13" "6" "1.036" "0.990" "0.975" "1.035" "1.051" "1.015" "1.028" "1.002" "0.922" "2266.2" "2347.1" "2243.7" "2210.4" "2345.1" "2381.3" "2300.2" "2330.0" "2270.4" "2090.1" "" "" "" "" "" "" "" "" "" "" "1200.0" "1301.3" "1285.0" "1018.0" "1268.8" "1324.6" "1353.7" "1271.8" "1273.6" "2090.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8235165147539186554" "False" "High" "IsMasterProtein" "Q16666" "Gamma-interferon-inducible protein 16 OS=Homo sapiens OX=9606 GN=IFI16 PE=1 SV=3" "0.000" "False" "52.822" "23" "13" "20" "11" "785" "88.2" "9.28" "51.14" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02758, Pf02760" "3428" "ENSG00000163565" "IFI16" "A0A346JEQ3; B4DJT8; H3BLV7; hsa:3428; Q16666; Q59GX0; Q5T3W7; Q5T3W8; Q5T3X0; Q5T3X1; Q5T3X2; Q8N9E5; Q8NEQ7; Q96AJ5; Q9UH78" "" "IRF3-mediated induction of type I IFN" "2" "1" "1.014" "1.028" "1.070" "1.052" "1.033" "1.036" "0.243" "1.029" "13.478" "506.6" "513.5" "521.0" "542.3" "533.0" "523.4" "524.6" "122.9" "521.4" "6827.6" "" "" "" "" "" "" "" "" "" "" "268.2" "284.7" "298.4" "249.7" "288.4" "291.1" "308.8" "67.1" "292.5" "6827.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4471349255838518587" "False" "High" "IsMasterProtein" "P23526" "Adenosylhomocysteinase OS=Homo sapiens OX=9606 GN=AHCY PE=1 SV=4" "0.000" "False" "52.732" "31" "12" "34" "11" "432" "47.7" "6.34" "96.34" "12" "other metabolic processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00670, Pf05221" "191" "ENSG00000101444" "AHCY" "A8K307; B3KUN3; E1P5P2; F5H737; hsa:191; P23526; Q96A36" "Folate metabolism; Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; Ethanol effects on histone modifications; Spina bifida" "Methylation; Sulfur amino acid metabolism; Metabolism of ingested SeMet, Sec, MeSec into H2Se; Defective AHCY causes HMAHCHD" "11" "1" "0.968" "0.924" "0.949" "0.975" "0.970" "0.912" "0.927" "0.972" "0.595" "3881.4" "3757.1" "3584.5" "3684.1" "3783.3" "3765.8" "3538.7" "3597.0" "3771.4" "2307.9" "" "" "" "" "" "" "" "" "" "" "2055.2" "2083.0" "2052.8" "1696.7" "2046.9" "2094.7" "2082.7" "1963.4" "2115.7" "2307.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-469021931412063719" "False" "High" "IsMasterProtein" "P53618" "Coatomer subunit beta OS=Homo sapiens OX=9606 GN=COPB1 PE=1 SV=3" "0.000" "False" "52.689" "15" "12" "20" "12" "953" "107.1" "6.05" "53.68" "12" "transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01602, Pf07718, Pf14806" "1315" "ENSG00000129083" "COPB1" "D3DQX0; hsa:1315; P53618; Q6GTT7; Q9NTK2; Q9UNW7" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Neutrophil degranulation" "3" "0" "1.072" "1.018" "0.965" "1.004" "1.009" "0.997" "1.024" "1.037" "1.106" "812.7" "871.1" "827.1" "784.3" "816.1" "819.6" "810.2" "832.1" "842.7" "898.4" "" "" "" "" "" "" "" "" "" "" "430.3" "482.9" "473.7" "361.2" "441.6" "455.9" "476.8" "454.2" "472.7" "898.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "516954531369469772" "False" "High" "IsMasterProtein" "P60900" "Proteasome subunit alpha type-6 OS=Homo sapiens OX=9606 GN=PSMA6 PE=1 SV=1" "0.000" "False" "52.645" "39" "9" "19" "9" "246" "27.4" "6.76" "58.22" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00227, Pf10584" "5687" "ENSG00000100902" "PSMA6" "B2R7J9; B4DQR4; B4DXJ9; hsa:5687; P34062; P60900; Q6IB60" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "0.960" "0.932" "0.929" "1.008" "1.003" "1.077" "1.009" "0.957" "0.561" "2401.5" "2304.4" "2237.0" "2230.0" "2421.0" "2409.2" "2585.9" "2423.0" "2297.7" "1347.0" "" "" "" "" "" "" "" "" "" "" "1271.6" "1277.6" "1281.1" "1027.0" "1309.9" "1340.1" "1521.9" "1322.6" "1289.0" "1347.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5833035186099414895" "False" "High" "IsMasterProtein" "Q96KR1" "Zinc finger RNA-binding protein OS=Homo sapiens OX=9606 GN=ZFR PE=1 SV=2" "0.000" "False" "52.632" "11" "11" "17" "11" "1074" "116.9" "9.04" "45.15" "11" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07528, Pf12874, Pf20965" "51663" "ENSG00000056097" "ZFR" "B2RNR5; hsa:51663; Q05C08; Q3B7X5; Q6P5A3; Q86UA0; Q96KR1; Q9H6V4; Q9NTI1; Q9Y687" "Exercise-induced circadian regulation" "" "1" "0" "0.991" "1.027" "1.062" "1.168" "1.070" "1.065" "1.068" "1.119" "0.914" "946.4" "937.8" "971.7" "1004.8" "1105.5" "1012.9" "1007.9" "1010.8" "1059.4" "865.5" "" "" "" "" "" "" "" "" "" "" "501.1" "519.9" "556.5" "462.8" "598.1" "563.4" "593.2" "551.8" "594.3" "865.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1739284738644474323" "False" "High" "IsMasterProtein" "P25098" "Beta-adrenergic receptor kinase 1 OS=Homo sapiens OX=9606 GN=GRK2 PE=1 SV=2" "0.000" "False" "52.603" "16" "12" "24" "12" "689" "79.5" "7.28" "68.77" "12" "cell-cell signaling;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf00169, Pf00615" "156" "ENSG00000173020" "GRK2" "B0ZBE1; hsa:156; P25098; Q13837; Q6GTT3" "Chemokine signaling pathway; Hedgehog signaling pathway; Hedgehog signaling pathway; HDAC6 interactions in the central nervous system" "G alpha (q) signalling events; Activation of SMO; G alpha (s) signalling events; Cargo recognition for clathrin-mediated endocytosis; Calmodulin induced events" "9" "0" "1.076" "1.040" "1.045" "1.128" "1.057" "0.959" "0.933" "0.959" "0.943" "1786.1" "1921.2" "1857.6" "1867.0" "2015.5" "1887.2" "1713.1" "1665.6" "1713.6" "1683.5" "" "" "" "" "" "" "" "" "" "" "945.7" "1065.2" "1063.8" "859.8" "1090.5" "1049.7" "1008.2" "909.2" "961.3" "1683.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2420827179212213562" "False" "High" "IsMasterProtein" "P30622" "CAP-Gly domain-containing linker protein 1 OS=Homo sapiens OX=9606 GN=CLIP1 PE=1 SV=2" "0.000" "False" "52.597" "11" "15" "17" "12" "1438" "162.1" "5.36" "49.16" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01302, Pf16641" "6249" "ENSG00000130779" "CLIP1" "A0AVD3; hsa:6249; P30622; Q17RS4; Q29RG0" "Microtubule cytoskeleton regulation; PAFAH1B1 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "9" "2" "1.025" "1.042" "1.062" "1.016" "1.027" "1.090" "1.067" "1.063" "0.929" "1365.0" "1399.7" "1421.9" "1449.0" "1386.7" "1402.5" "1487.6" "1456.5" "1450.6" "1267.7" "" "" "" "" "" "" "" "" "" "" "722.8" "776.0" "814.3" "667.3" "750.3" "780.2" "875.5" "795.0" "813.7" "1267.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6518875519697934580" "False" "High" "IsMasterProtein" "Q92576" "PHD finger protein 3 OS=Homo sapiens OX=9606 GN=PHF3 PE=1 SV=3" "0.000" "False" "52.585" "7" "14" "15" "14" "2039" "229.3" "6.96" "41.31" "14" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00628, Pf07500, Pf07744" "23469" "ENSG00000118482" "PHF3" "A3KFI8; hsa:23469; Q14CR5; Q5CZI1; Q5T1T6; Q92576; Q9NQ16; Q9UI45" "" "" "0" "0" "1.025" "1.034" "1.045" "1.092" "1.071" "1.191" "1.218" "1.245" "0.718" "1274.7" "1306.6" "1318.4" "1332.2" "1392.4" "1365.2" "1517.6" "1552.5" "1587.4" "915.2" "" "" "" "" "" "" "" "" "" "" "675.0" "724.4" "755.1" "613.5" "753.4" "759.4" "893.2" "847.4" "890.5" "915.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1348431233397446306" "False" "High" "IsMasterProtein" "P62495" "Eukaryotic peptide chain release factor subunit 1 OS=Homo sapiens OX=9606 GN=ETF1 PE=1 SV=3" "0.000" "False" "52.516" "20" "8" "22" "8" "437" "49.0" "5.71" "62.05" "8" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf03463, Pf03464, Pf03465" "2107" "ENSG00000120705" "ETF1" "B2R6B4; D3DQC1; hsa:2107; P46055; P62495; Q5M7Z7; Q96CG1" "Translation factors" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Protein hydroxylation" "6" "0" "1.014" "0.985" "1.058" "1.046" "1.019" "1.043" "1.020" "0.982" "0.830" "1381.3" "1400.7" "1360.4" "1461.9" "1445.1" "1407.2" "1440.5" "1409.1" "1356.2" "1147.0" "" "" "" "" "" "" "" "" "" "" "731.4" "776.6" "779.1" "673.2" "781.9" "782.7" "847.8" "769.1" "760.8" "1147.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7523949865199722082" "False" "High" "IsMasterProtein" "P50579" "Methionine aminopeptidase 2 OS=Homo sapiens OX=9606 GN=METAP2 PE=1 SV=1" "0.000" "False" "52.498" "24" "9" "16" "9" "478" "52.9" "5.82" "54.27" "9" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00557" "10988" "ENSG00000111142" "METAP2" "B2RDI8; B4DUX5; G3XA91; hsa:10988; P50579; Q8NB11" "" "Inactivation, recovery and regulation of the phototransduction cascade" "1" "0" "1.033" "1.079" "1.014" "1.087" "1.093" "1.050" "1.040" "1.071" "0.717" "1336.6" "1381.2" "1442.4" "1355.9" "1452.3" "1461.1" "1403.6" "1390.4" "1431.1" "957.7" "" "" "" "" "" "" "" "" "" "" "707.7" "765.8" "826.0" "624.4" "785.8" "812.7" "826.0" "759.0" "802.8" "957.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2468696703933973892" "False" "High" "IsMasterProtein" "P23921" "Ribonucleoside-diphosphate reductase large subunit OS=Homo sapiens OX=9606 GN=RRM1 PE=1 SV=1" "0.000" "False" "52.464" "18" "15" "29" "15" "792" "90.0" "7.15" "65.51" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00317, Pf02867, Pf03477" "6240" "ENSG00000167325" "RRM1" "hsa:6240; P23921; Q9UNN2" "Fluoropyrimidine activity; Retinoblastoma gene in cancer; Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "4" "0" "0.961" "0.928" "0.872" "0.929" "0.931" "0.863" "0.950" "0.935" "0.481" "2914.7" "2799.7" "2704.0" "2540.2" "2706.3" "2712.3" "2515.9" "2768.6" "2725.6" "1401.2" "" "" "" "" "" "" "" "" "" "" "1543.3" "1552.3" "1548.6" "1169.9" "1464.2" "1508.7" "1480.7" "1511.2" "1529.0" "1401.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4598318327767700223" "False" "High" "IsMasterProtein" "Q96SI9" "Spermatid perinuclear RNA-binding protein OS=Homo sapiens OX=9606 GN=STRBP PE=1 SV=1" "0.000" "False" "52.425" "18" "12" "20" "8" "672" "73.6" "8.72" "55.58" "12" "other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity" "Pf00035, Pf07528, Pf20965" "55342" "ENSG00000165209" "STRBP" "hsa:55342; Q32NB9; Q96SI9; Q9BUE1; Q9BXG4; Q9H0B4; Q9H7V1; Q9NUK4" "" "" "0" "0" "1.061" "1.014" "1.168" "1.150" "1.137" "1.114" "0.961" "1.050" "1.985" "646.2" "685.5" "655.0" "755.0" "743.3" "734.7" "720.2" "621.0" "678.6" "1282.6" "" "" "" "" "" "" "" "" "" "" "342.2" "380.0" "375.1" "347.7" "402.1" "408.7" "423.9" "339.0" "380.7" "1282.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1866201622056559647" "False" "High" "IsMasterProtein" "Q13263" "Transcription intermediary factor 1-beta OS=Homo sapiens OX=9606 GN=TRIM28 PE=1 SV=5" "0.000" "False" "52.418" "19" "14" "25" "14" "835" "88.5" "5.77" "69.28" "14" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00628, Pf00643, Pf14634" "10155" "ENSG00000130726" "TRIM28" "hsa:10155; O00677; Q13263; Q7Z632; Q93040; Q96IM1" "Corticotropin-releasing hormone signaling pathway; Mesodermal commitment pathway; ATM signaling in development and disease" "HCMV Early Events; Generic Transcription Pathway; SUMOylation of transcription cofactors" "6" "0" "1.055" "0.991" "1.075" "1.045" "1.053" "1.114" "0.650" "1.134" "5.684" "1231.1" "1298.9" "1220.5" "1323.4" "1286.5" "1296.7" "1371.8" "800.5" "1395.8" "6997.3" "" "" "" "" "" "" "" "" "" "" "651.9" "720.1" "699.0" "609.5" "696.0" "721.3" "807.4" "437.0" "783.0" "6997.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3418505594273786343" "False" "High" "IsMasterProtein" "P48735" "Isocitrate dehydrogenase [NADP], mitochondrial OS=Homo sapiens OX=9606 GN=IDH2 PE=1 SV=2" "0.000" "False" "52.355" "24" "10" "25" "9" "452" "50.9" "8.69" "70.61" "10" "other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf00180" "3418" "ENSG00000182054" "IDH2" "B2R6L6; B4DFL2; hsa:3418; P48735; Q96GT3" "VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer; Cerebral organic acidurias, including diseases; TCA cycle (aka Krebs or citric acid cycle)" "Transcriptional activation of mitochondrial biogenesis; Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "7" "1" "0.971" "0.993" "0.936" "0.964" "0.987" "0.833" "0.822" "0.799" "0.568" "2626.2" "2550.9" "2607.1" "2458.5" "2532.9" "2592.1" "2186.8" "2158.9" "2099.2" "1491.0" "" "" "" "" "" "" "" "" "" "" "1390.6" "1414.3" "1493.1" "1132.2" "1370.4" "1441.9" "1287.0" "1178.4" "1177.6" "1491.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-933507358187812304" "False" "High" "IsMasterProtein" "P48634" "Protein PRRC2A OS=Homo sapiens OX=9606 GN=PRRC2A PE=1 SV=3" "0.000" "False" "52.175" "6" "11" "14" "10" "2157" "228.7" "9.45" "40.96" "11" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "" "Pf07001" "7916" "ENSG00000204469; ENSG00000206427; ENSG00000225164; ENSG00000225748; ENSG00000226618; ENSG00000231370; ENSG00000231825" "PRRC2A" "B0UX77; B0UZE9; B0UZL3; hsa:7916; O95875; P48634; Q05BK4; Q4LE37; Q5SQ29; Q5SQ30; Q5ST84; Q5STX6; Q5STX7; Q68DW9; Q6P9P7; Q6PIN1; Q8MGQ9; Q96QC6" "" "" "0" "0" "1.024" "1.096" "1.081" "1.078" "1.030" "1.096" "1.156" "1.165" "0.486" "1154.9" "1182.3" "1265.2" "1248.8" "1245.0" "1189.0" "1266.2" "1335.3" "1345.9" "561.8" "" "" "" "" "" "" "" "" "" "" "611.5" "655.5" "724.6" "575.1" "673.6" "661.4" "745.2" "728.9" "755.0" "561.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7462391840116260305" "False" "High" "IsMasterProtein" "Q05086" "Ubiquitin-protein ligase E3A OS=Homo sapiens OX=9606 GN=UBE3A PE=1 SV=4" "0.000" "False" "52.073" "14" "13" "19" "13" "875" "100.6" "5.22" "53.24" "13" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00632, Pf16558" "7337" "ENSG00000114062" "UBE3A" "A8K8Z9; hsa:7337; P78355; Q05086; Q93066; Q9UEP4; Q9UEP5; Q9UEP6; Q9UEP7; Q9UEP8; Q9UEP9" "Androgen receptor signaling pathway; MECP2 and associated Rett syndrome; Prader-Willi and Angelman syndrome; Synaptic signaling pathways associated with autism spectrum disorder" "Antigen processing: Ubiquitination & Proteasome degradation" "5" "0" "0.969" "0.984" "1.049" "0.985" "1.034" "0.975" "0.993" "0.965" "0.859" "1731.3" "1678.1" "1702.8" "1815.5" "1704.7" "1790.5" "1687.3" "1718.3" "1671.1" "1486.4" "" "" "" "" "" "" "" "" "" "" "916.7" "930.4" "975.2" "836.1" "922.3" "996.0" "993.0" "938.0" "937.5" "1486.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5335677543697524354" "False" "High" "IsMasterProtein" "P17844" "Probable ATP-dependent RNA helicase DDX5 OS=Homo sapiens OX=9606 GN=DDX5 PE=1 SV=1" "0.000" "False" "51.806" "19" "12" "16" "7" "614" "69.1" "8.92" "38.41" "12" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf08061" "1655" "ENSG00000108654" "DDX5" "B4DLW8; B5BU21; D3DU32; E7ETL9; hsa:1655; O75681; P17844; Q53Y61" "Ciliary landscape" "mRNA Splicing - Major Pathway; Estrogen-dependent gene expression; SUMOylation of transcription cofactors; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome" "6" "0" "0.952" "0.899" "0.979" "0.997" "0.995" "0.948" "0.597" "0.932" "4.952" "664.5" "632.7" "597.5" "650.4" "662.3" "661.2" "630.0" "396.9" "619.3" "3290.8" "" "" "" "" "" "" "" "" "" "" "351.9" "350.8" "342.2" "299.5" "358.3" "367.8" "370.8" "216.6" "347.4" "3290.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6180366262275080504" "False" "High" "IsMasterProtein" "P00505" "Aspartate aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=GOT2 PE=1 SV=3" "0.000" "False" "51.617" "27" "12" "30" "12" "430" "47.5" "9.01" "71.05" "12" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;mitochondrion" "other molecular function" "Pf00155" "2806" "ENSG00000125166" "GOT2" "B4DJA6; E7ERW2; hsa:2806; P00505; Q53FL3; Q9BWA3" "Alanine and aspartate metabolism; Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glyoxylate metabolism and glycine degradation; Gluconeogenesis; Aspartate and asparagine metabolism; Glutamate and glutamine metabolism; Degradation of cysteine and homocysteine" "11" "0" "0.941" "1.012" "0.778" "0.932" "0.970" "1.046" "0.935" "0.962" "0.500" "2519.1" "2369.5" "2548.5" "1959.0" "2349.0" "2442.9" "2634.0" "2355.1" "2423.4" "1260.0" "" "" "" "" "" "" "" "" "" "" "1333.8" "1313.7" "1459.5" "902.2" "1270.9" "1358.9" "1550.2" "1285.5" "1359.5" "1260.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4501130865097894528" "False" "High" "IsMasterProtein" "O60763" "General vesicular transport factor p115 OS=Homo sapiens OX=9606 GN=USO1 PE=1 SV=2" "0.000" "False" "51.460" "13" "11" "11" "11" "962" "107.8" "4.91" "37.78" "11" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "" "Pf04869, Pf04871, Pf18770" "8615" "ENSG00000138768" "USO1" "B2RAQ0; hsa:8615; O60763; Q6PK63; Q86TB8; Q8N592" "" "COPI-mediated anterograde transport; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization" "3" "0" "1.012" "0.990" "0.996" "1.003" "0.986" "0.922" "0.933" "0.898" "1.582" "1121.6" "1135.4" "1110.6" "1116.5" "1125.2" "1106.2" "1033.6" "1046.7" "1006.8" "1774.9" "" "" "" "" "" "" "" "" "" "" "593.9" "629.5" "636.1" "514.2" "608.8" "615.3" "608.3" "571.3" "564.8" "1774.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8782574511401724651" "False" "High" "IsMasterProtein" "Q06124" "Tyrosine-protein phosphatase non-receptor type 11 OS=Homo sapiens OX=9606 GN=PTPN11 PE=1 SV=3" "0.000" "False" "51.331" "23" "14" "19" "14" "593" "68.0" "7.30" "49.46" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00102" "5781" "ENSG00000179295" "PTPN11" "A8K1D9; hsa:5781; Q06124; Q96HD7" "IL-5 signaling pathway; Heart development; IL-1 signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Pilocytic astrocytoma; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling; Embryonic stem cell pluripotency pathways; IL-4 signaling pathway; MET in type 1 papillary renal cell carcinoma; Ras signaling; EGF/EGFR signaling pathway; Fragile X syndrome; Cancer immunotherapy by CTLA4 blockade; Cancer immunotherapy by PD-1 blockade; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; Insulin signaling; IL-2 signaling pathway; Angiotensin II receptor type 1 pathway; Kallmann syndrome; Orexin receptor pathway; GDNF signaling; Interferon type I signaling pathways; Type II interferon signaling; T-cell receptor signaling pathway" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PD-1 signaling; PIP3 activates AKT signaling; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; Signal regulatory protein family interactions; Constitutive Signaling by Aberrant PI3K in Cancer; Interleukin-3, Interleukin-5 and GM-CSF signaling; RET signaling; PI3K Cascade; GPVI-mediated activation cascade; Signaling by SCF-KIT; Downstream signal transduction; Tie2 Signaling; Interleukin-6 signaling; Signaling by Leptin; Regulation of IFNG signaling; Regulation of IFNA/IFNB signaling; Signaling by CSF3 (G-CSF); GAB1 signalosome; Signaling by CSF1 (M-CSF) in myeloid cells; PI-3K cascade:FGFR1; FRS-mediated FGFR1 signaling; PI-3K cascade:FGFR2; FRS-mediated FGFR2 signaling; FRS-mediated FGFR3 signaling; PI-3K cascade:FGFR3; FRS-mediated FGFR4 signaling; PI-3K cascade:FGFR4; Activated NTRK2 signals through FRS2 and FRS3; Spry regulation of FGF signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; Prolactin receptor signaling; Interleukin-20 family signaling; Netrin mediated repulsion signals; Interleukin-37 signaling; Signaling by FLT3 ITD and TKD mutants; Platelet sensitization by LDL; PECAM1 interactions; CTLA4 inhibitory signaling; MET activates PTPN11; STAT5 activation downstream of FLT3 ITD mutants; Regulation of RUNX1 Expression and Activity; STAT5 Activation" "91" "0" "0.995" "0.955" "0.944" "0.977" "0.977" "0.975" "0.977" "0.983" "0.765" "1557.0" "1549.3" "1487.1" "1469.2" "1521.2" "1521.1" "1518.0" "1521.7" "1530.2" "1191.4" "" "" "" "" "" "" "" "" "" "" "824.4" "858.9" "851.6" "676.6" "823.0" "846.1" "893.4" "830.6" "858.4" "1191.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4305624722430213023" "False" "High" "IsMasterProtein" "Q9H4A3" "Serine/threonine-protein kinase WNK1 OS=Homo sapiens OX=9606 GN=WNK1 PE=1 SV=2" "0.000" "False" "51.303" "7" "17" "25" "17" "2382" "250.6" "6.34" "55.66" "17" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf12202" "65125" "ENSG00000060237" "WNK1" "A1L4B0; C5HTZ5; C5HTZ6; C5HTZ7; H6WZW3; hsa:65125; O15052; P54963; Q4VBX9; Q6IFS5; Q86WL5; Q8N673; Q96CZ6; Q9H4A3; Q9P1S9" "Ciliary landscape" "Stimuli-sensing channels" "2" "0" "1.044" "1.079" "1.140" "0.999" "1.037" "1.047" "1.130" "1.058" "0.802" "1630.2" "1702.6" "1758.3" "1857.7" "1628.2" "1690.4" "1707.0" "1841.3" "1724.7" "1306.8" "" "" "" "" "" "" "" "" "" "" "863.2" "944.0" "1007.0" "855.6" "880.9" "940.3" "1004.6" "1005.1" "967.5" "1306.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7589685267009723312" "False" "High" "IsMasterProtein" "Q9H0D6" "5'-3' exoribonuclease 2 OS=Homo sapiens OX=9606 GN=XRN2 PE=1 SV=1" "0.000" "False" "51.233" "11" "11" "19" "11" "950" "108.5" "7.47" "42.84" "11" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03159, Pf17846" "22803" "ENSG00000088930" "XRN2" "hsa:22803; Q3L8N4; Q6KGZ9; Q9BQL1; Q9H0D6; Q9NTW0; Q9NXS6; Q9UL53" "mRNA processing" "Major pathway of rRNA processing in the nucleolus and cytosol; Association of TriC/CCT with target proteins during biosynthesis" "3" "0" "1.000" "1.021" "1.316" "1.085" "1.052" "1.343" "1.227" "2.218" "0.843" "1096.4" "1096.6" "1119.2" "1443.2" "1189.1" "1153.6" "1472.4" "1345.3" "2432.2" "924.4" "" "" "" "" "" "" "" "" "" "" "580.5" "608.0" "641.0" "664.6" "643.3" "641.7" "866.5" "734.3" "1364.4" "924.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8484028389043526679" "False" "High" "IsMasterProtein" "P13010" "X-ray repair cross-complementing protein 5 OS=Homo sapiens OX=9606 GN=XRCC5 PE=1 SV=3" "0.000" "False" "51.161" "14" "11" "18" "11" "732" "82.7" "5.81" "50.61" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf02735, Pf03730, Pf03731, Pf08785" "7520" "ENSG00000079246" "XRCC5" "A8K3X5; hsa:7520; P13010; Q0Z7V0; Q4VBQ5; Q53HH7; Q7M4N0; Q9UCQ0; Q9UCQ1" "Non-homologous end joining; Male infertility; DNA repair pathways, full network; p53 transcriptional gene network" "Neutrophil degranulation; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation; IRF3-mediated induction of type I IFN" "9" "0" "1.071" "1.093" "1.364" "1.309" "1.338" "2.206" "2.147" "2.261" "3.146" "878.9" "941.4" "960.8" "1198.8" "1150.8" "1175.8" "1938.9" "1887.4" "1987.1" "2764.8" "" "" "" "" "" "" "" "" "" "" "465.4" "521.9" "550.3" "552.1" "622.6" "654.0" "1141.1" "1030.2" "1114.7" "2764.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "479793662138796228" "False" "High" "IsMasterProtein" "P61221" "ATP-binding cassette sub-family E member 1 OS=Homo sapiens OX=9606 GN=ABCE1 PE=1 SV=1" "0.000" "False" "50.769" "16" "10" "17" "10" "599" "67.3" "8.34" "44.30" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;mitochondrion;translational apparatus;other cell component" "enzyme regulator activity;translation activity;other molecular function" "Pf00005, Pf00037, Pf04068" "6059" "ENSG00000164163" "ABCE1" "hsa:6059; O88793; P61221; Q13181; Q13864; Q6NR76; Q96AL0; Q96B10; Q99K66" "" "OAS antiviral response; Interferon alpha/beta signaling" "2" "0" "1.000" "0.981" "0.971" "1.022" "1.021" "0.971" "1.063" "0.987" "0.613" "1124.1" "1123.8" "1102.8" "1091.0" "1149.2" "1147.5" "1091.8" "1194.7" "1109.4" "689.4" "" "" "" "" "" "" "" "" "" "" "595.2" "623.1" "631.6" "502.4" "621.8" "638.3" "642.5" "652.1" "622.3" "689.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1828229649447777005" "False" "High" "IsMasterProtein" "P31153" "S-adenosylmethionine synthase isoform type-2 OS=Homo sapiens OX=9606 GN=MAT2A PE=1 SV=1" "0.000" "False" "50.760" "27" "11" "22" "11" "395" "43.6" "6.48" "68.22" "11" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00438, Pf02772, Pf02773" "4144" "ENSG00000168906" "MAT2A" "A8K511; B4DN45; D6W5L1; hsa:4144; P31153; Q53SP5" "Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; One-carbon metabolism and related pathways; Methylation pathways" "Methylation" "5" "0" "0.913" "0.927" "0.872" "0.892" "0.922" "0.896" "0.875" "0.854" "0.494" "3447.6" "3146.4" "3196.6" "3005.9" "3076.2" "3178.5" "3089.5" "3017.6" "2944.4" "1703.9" "" "" "" "" "" "" "" "" "" "" "1825.5" "1744.5" "1830.7" "1384.3" "1664.4" "1768.0" "1818.3" "1647.2" "1651.7" "1703.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2355880035621835112" "False" "High" "IsMasterProtein" "O15067" "Phosphoribosylformylglycinamidine synthase OS=Homo sapiens OX=9606 GN=PFAS PE=1 SV=4" "0.000" "False" "50.482" "12" "16" "26" "16" "1338" "144.6" "5.76" "62.94" "16" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf02769, Pf13507, Pf18072, Pf18076" "5198" "ENSG00000178921" "PFAS" "A6H8V8; hsa:5198; O15067" "" "Purine ribonucleoside monophosphate biosynthesis" "1" "0" "1.087" "0.843" "0.989" "0.976" "0.969" "1.026" "1.011" "0.972" "1.325" "1295.0" "1407.3" "1091.9" "1281.2" "1264.1" "1254.8" "1328.3" "1309.6" "1259.3" "1716.2" "" "" "" "" "" "" "" "" "" "" "685.7" "780.3" "625.3" "590.0" "683.9" "698.0" "781.7" "714.9" "706.4" "1716.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7644877244443849971" "False" "High" "IsMasterProtein" "Q13177" "Serine/threonine-protein kinase PAK 2 OS=Homo sapiens OX=9606 GN=PAK2 PE=1 SV=3" "0.000" "False" "50.428" "21" "10" "19" "9" "524" "58.0" "5.96" "41.90" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00786" "5062" "ENSG00000180370" "PAK2" "hsa:5062; Q13154; Q13177; Q6ISC3" "Integrin-mediated cell adhesion; Apoptosis-related network due to altered Notch3 in ovarian cancer; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; MET in type 1 papillary renal cell carcinoma; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 3q29 copy number variation syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; FCERI mediated MAPK activation; Regulation of activated PAK-2p34 by proteasome mediated degradation; MAPK6/MAPK4 signaling; RHOV GTPase cycle; Smooth Muscle Contraction; Generation of second messenger molecules; Regulation of PAK-2p34 activity by PS-GAP/RHG10; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOU GTPase cycle; Ephrin signaling; Sema3A PAK dependent Axon repulsion; RHO GTPases activate PAKs; VEGFR2 mediated vascular permeability; Activation of RAC1; RHOH GTPase cycle; CD209 (DC-SIGN) signaling; CD28 dependent Vav1 pathway; Nef and signal transduction; Stimulation of the cell death response by PAK-2p34" "45" "1" "1.013" "0.986" "0.996" "1.038" "1.024" "0.964" "0.956" "0.918" "0.682" "1180.5" "1195.4" "1164.4" "1176.1" "1225.5" "1208.5" "1137.5" "1128.4" "1083.5" "805.5" "" "" "" "" "" "" "" "" "" "" "625.1" "662.7" "666.8" "541.7" "663.0" "672.2" "669.5" "615.9" "607.8" "805.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3453678624484122586" "False" "High" "IsMasterProtein" "Q8WUM4" "Programmed cell death 6-interacting protein OS=Homo sapiens OX=9606 GN=PDCD6IP PE=1 SV=1" "0.000" "False" "50.401" "14" "13" "19" "13" "868" "96.0" "6.52" "52.01" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf03097, Pf13949" "10015" "ENSG00000170248" "PDCD6IP" "C5MQH7; E9PFU1; hsa:10015; Q6NUS1; Q8WUM4; Q9BX86; Q9NUN0; Q9P2H2; Q9UKL5" "Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells" "Budding and maturation of HIV virion; Regulation of necroptotic cell death; Uptake and function of anthrax toxins" "5" "0" "0.905" "0.998" "1.000" "0.871" "0.915" "0.956" "0.468" "0.829" "5.561" "1005.1" "909.3" "1003.3" "1005.4" "875.8" "919.6" "960.9" "470.7" "833.6" "5589.8" "" "" "" "" "" "" "" "" "" "" "532.2" "504.1" "574.6" "463.0" "473.8" "511.5" "565.5" "256.9" "467.6" "5589.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1757040485264551221" "False" "High" "IsMasterProtein" "Q9Y6A5" "Transforming acidic coiled-coil-containing protein 3 OS=Homo sapiens OX=9606 GN=TACC3 PE=1 SV=1" "0.000" "False" "50.159" "13" "10" "12" "10" "838" "90.3" "5.05" "33.90" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf05010" "10460" "ENSG00000013810" "TACC3" "hsa:10460; Q2NKK4; Q3KQS5; Q9UMQ1; Q9Y6A5" "4p16.3 copy number variation" "Negative regulation of NOTCH4 signaling; NOTCH3 Activation and Transmission of Signal to the Nucleus" "3" "0" "1.080" "1.127" "0.964" "0.993" "0.988" "0.833" "0.951" "0.911" "0.740" "1310.4" "1415.8" "1476.5" "1262.8" "1301.5" "1294.3" "1091.5" "1246.3" "1193.7" "969.8" "" "" "" "" "" "" "" "" "" "" "693.9" "785.0" "845.6" "581.6" "704.2" "719.9" "642.4" "680.3" "669.6" "969.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4952006714438079555" "False" "High" "IsMasterProtein" "Q9Y4L1" "Hypoxia up-regulated protein 1 OS=Homo sapiens OX=9606 GN=HYOU1 PE=1 SV=1" "0.000" "False" "50.099" "15" "14" "20" "14" "999" "111.3" "5.22" "51.93" "14" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cell component" "other molecular function" "Pf00012" "10525" "ENSG00000149428; ENSG00000280682" "HYOU1" "A8C1Z0; B7Z909; hsa:10525; Q2I204; Q53H25; Q9Y4L1" "VEGFA-VEGFR2 signaling" "XBP1(S) activates chaperone genes; Scavenging by Class F Receptors" "3" "0" "1.028" "1.031" "0.981" "0.957" "0.912" "0.892" "0.837" "0.923" "2.483" "988.3" "1016.4" "1018.6" "969.2" "946.2" "901.8" "882.0" "826.9" "912.6" "2453.7" "" "" "" "" "" "" "" "" "" "" "523.3" "563.5" "583.4" "446.3" "512.0" "501.6" "519.1" "451.4" "512.0" "2453.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3232925650926593770" "False" "High" "IsMasterProtein" "Q9C0C2" "182 kDa tankyrase-1-binding protein OS=Homo sapiens OX=9606 GN=TNKS1BP1 PE=1 SV=4" "0.000" "False" "50.075" "7" "11" "14" "11" "1729" "181.7" "4.86" "42.80" "11" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15327" "85456" "ENSG00000149115" "TNKS1BP1" "A7E2F8; hsa:85456; Q6PJ35; Q6ZV74; Q9C0C2" "Ciliary landscape" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "4" "0" "1.046" "1.041" "1.084" "1.060" "1.020" "1.034" "1.190" "1.140" "0.581" "1165.7" "1219.7" "1213.1" "1263.8" "1235.3" "1189.5" "1205.0" "1386.8" "1328.9" "676.8" "" "" "" "" "" "" "" "" "" "" "617.2" "676.2" "694.7" "582.0" "668.3" "661.7" "709.2" "757.0" "745.5" "676.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4288023909312929848" "False" "High" "IsMasterProtein" "P06744" "Glucose-6-phosphate isomerase OS=Homo sapiens OX=9606 GN=GPI PE=1 SV=4" "0.000" "False" "49.959" "23" "13" "38" "13" "558" "63.1" "8.32" "103.67" "13" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00342" "2821" "ENSG00000105220" "GPI" "B4DG39; hsa:2821; P06744; Q9BRD3; Q9BSK5; Q9UHE6" "Cori cycle; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; N-glycan biosynthesis; Disorders of fructose metabolism; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; UDP-derived sugars synthesis in fibroblasts" "Neutrophil degranulation; Glycolysis; Gluconeogenesis; TP53 Regulates Metabolic Genes" "13" "0" "0.964" "0.940" "0.953" "0.903" "0.965" "0.939" "0.955" "0.938" "0.624" "5417.8" "5222.0" "5093.5" "5162.5" "4890.5" "5226.6" "5089.3" "5176.4" "5083.3" "3379.6" "" "" "" "" "" "" "" "" "" "" "2868.7" "2895.2" "2917.0" "2377.5" "2645.9" "2907.3" "2995.2" "2825.5" "2851.6" "3379.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5486623488286150829" "False" "High" "IsMasterProtein" "Q9UBT2" "SUMO-activating enzyme subunit 2 OS=Homo sapiens OX=9606 GN=UBA2 PE=1 SV=2" "0.000" "False" "49.771" "16" "10" "27" "10" "640" "71.2" "5.29" "75.98" "10" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00899, Pf14732, Pf16195" "10054" "ENSG00000126261" "UBA2" "B3KWB9; hsa:10054; O95605; Q59H87; Q6IBP6; Q9NTJ1; Q9UBT2; Q9UED2" "" "SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "2" "0" "0.957" "0.985" "0.915" "0.934" "1.023" "0.911" "0.979" "0.999" "0.899" "3158.1" "3023.5" "3111.4" "2890.4" "2950.9" "3231.3" "2877.8" "3091.9" "3156.3" "2838.6" "" "" "" "" "" "" "" "" "" "" "1672.2" "1676.3" "1781.9" "1331.1" "1596.6" "1797.4" "1693.7" "1687.7" "1770.6" "2838.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-109273256828227415" "False" "High" "IsMasterProtein" "Q07866" "Kinesin light chain 1 OS=Homo sapiens OX=9606 GN=KLC1 PE=1 SV=2" "0.000" "False" "49.721" "25" "15" "20" "13" "573" "65.3" "6.20" "53.30" "15" "cell adhesion;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00515, Pf13374, Pf13424" "3831" "ENSG00000126214" "KLC1" "A6NF62; F8VTM4; hsa:3831; Q07866; Q7RTM2; Q7RTM3; Q7RTM5; Q7RTP9; Q7RTQ3; Q7RTQ5; Q7RTQ6; Q86SF5; Q86TF5; Q86V74; Q86V75; Q86V76; Q86V77; Q86V78; Q86V79; Q96H62" "Alzheimer's disease and miRNA effects; IL-18 signaling pathway; Alzheimer's disease" "Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; RHO GTPases activate KTN1" "8" "2" "1.043" "1.046" "0.952" "1.059" "1.023" "0.878" "0.892" "0.941" "0.899" "2039.4" "2127.6" "2133.0" "1940.5" "2160.0" "2086.8" "1789.6" "1819.8" "1919.0" "1833.8" "" "" "" "" "" "" "" "" "" "" "1079.9" "1179.6" "1221.6" "893.7" "1168.7" "1160.8" "1053.2" "993.3" "1076.5" "1833.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5340528139668487905" "False" "High" "IsMasterProtein" "O95831" "Apoptosis-inducing factor 1, mitochondrial OS=Homo sapiens OX=9606 GN=AIFM1 PE=1 SV=1" "0.000" "False" "49.714" "15" "8" "12" "8" "613" "66.9" "8.95" "35.07" "8" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00070, Pf14721" "9131" "ENSG00000156709" "AIFM1" "A4QPB4; B1ALN1; B2RB08; D3DTE9; E9PRR0; O95831; Q1L6K4; Q1L6K6; Q2QKE4; Q5JUZ7; Q6I9X6; Q9Y3I3; Q9Y3I4" "Apoptosis modulation and signaling; Nanomaterial induced apoptosis; Apoptosis modulation by HSP70" "" "3" "0" "0.970" "0.940" "0.913" "0.939" "0.949" "0.917" "1.027" "0.859" "0.222" "1451.3" "1407.7" "1364.7" "1325.6" "1362.8" "1377.4" "1330.4" "1490.9" "1246.5" "321.5" "" "" "" "" "" "" "" "" "" "" "768.5" "780.5" "781.6" "610.5" "737.3" "766.2" "783.0" "813.8" "699.2" "321.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6072286448447602827" "False" "High" "IsMasterProtein" "Q9UBE0" "SUMO-activating enzyme subunit 1 OS=Homo sapiens OX=9606 GN=SAE1 PE=1 SV=1" "0.000" "False" "49.474" "21" "8" "11" "8" "346" "38.4" "5.30" "41.33" "8" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00899" "10055" "ENSG00000142230" "SAE1" "B2RDP5; B3KMQ2; F5GXX7; G3XAK6; hsa:10055; O95717; Q9P020; Q9UBE0" "" "SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "2" "0" "0.981" "0.978" "0.978" "0.952" "0.983" "0.919" "0.980" "0.915" "0.704" "1994.7" "1956.6" "1951.6" "1950.2" "1898.8" "1961.1" "1832.3" "1955.7" "1824.5" "1404.2" "" "" "" "" "" "" "" "" "" "" "1056.2" "1084.8" "1117.7" "898.1" "1027.3" "1090.8" "1078.3" "1067.6" "1023.5" "1404.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174373993236338878" "False" "High" "IsMasterProtein" "Q15233" "Non-POU domain-containing octamer-binding protein OS=Homo sapiens OX=9606 GN=NONO PE=1 SV=4" "0.000" "False" "49.261" "25" "12" "23" "10" "471" "54.2" "8.95" "52.80" "12" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08075" "4841" "ENSG00000147140" "NONO" "B7Z4C2; D3DVV4; F5GYZ3; hsa:4841; O00201; P30807; Q12786; Q15233; Q9BQC5" "mRNA processing" "" "1" "1" "1.045" "1.049" "1.268" "1.159" "1.142" "1.380" "0.518" "1.256" "10.501" "667.4" "697.4" "700.3" "846.1" "773.3" "762.1" "921.3" "345.8" "838.1" "7008.8" "" "" "" "" "" "" "" "" "" "" "353.4" "386.7" "401.0" "389.6" "418.4" "423.9" "542.2" "188.7" "470.2" "7008.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5275540959932174837" "False" "High" "IsMasterProtein" "Q14847" "LIM and SH3 domain protein 1 OS=Homo sapiens OX=9606 GN=LASP1 PE=1 SV=2" "0.000" "False" "48.976" "41" "10" "26" "10" "261" "29.7" "7.05" "76.72" "10" "transport" "cytoskeleton;other cell component" "transporter activity;cytoskeletal activity;other molecular function" "Pf00412, Pf00880, Pf14604" "3927" "ENSG00000002834" "LASP1" "B4DGQ0; hsa:3927; Q14847; Q96ED2; Q96IG0" "17q12 copy number variation syndrome" "" "1" "0" "0.962" "1.062" "1.044" "0.790" "0.827" "0.801" "0.899" "0.773" "0.432" "2725.7" "2622.5" "2896.0" "2846.0" "2154.0" "2255.4" "2183.9" "2450.5" "2106.7" "1178.4" "" "" "" "" "" "" "" "" "" "" "1443.3" "1454.0" "1658.6" "1310.7" "1165.4" "1254.5" "1285.3" "1337.6" "1181.8" "1178.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7881821209807726399" "False" "High" "IsMasterProtein" "O75153" "Clustered mitochondria protein homolog OS=Homo sapiens OX=9606 GN=CLUH PE=1 SV=2" "0.000" "False" "48.599" "10" "14" "15" "14" "1309" "146.6" "6.13" "40.68" "14" "cell organization and biogenesis" "other cell component" "nucleic acid binding activity" "Pf12807, Pf13236, Pf13374, Pf13424, Pf15044" "23277" "ENSG00000132361" "CLUH" "hsa:23277; O75153; Q6AHY2; Q6P3X7; Q6ZUG8; Q8N4U7; Q9BTA3; Q9H979" "Translation factors" "" "1" "0" "1.102" "1.109" "1.076" "1.135" "1.221" "1.038" "0.697" "1.076" "4.913" "510.7" "562.8" "566.3" "549.7" "579.5" "623.5" "530.1" "355.9" "549.5" "2509.2" "" "" "" "" "" "" "" "" "" "" "270.4" "312.1" "324.3" "253.2" "313.6" "346.8" "312.0" "194.3" "308.3" "2509.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "945585302651271031" "False" "High" "IsMasterProtein" "P43243" "Matrin-3 OS=Homo sapiens OX=9606 GN=MATR3 PE=1 SV=2" "0.000" "False" "48.362" "14" "11" "13" "11" "847" "94.6" "6.25" "40.87" "11" "stress response;developmental processes;other biological processes" "other membranes;nucleus" "nucleic acid binding activity;other molecular function" "" "9782" "ENSG00000015479" "MATR3" "B7ZAV5; D3DQC3; hsa:9782; P43243; Q9UHW0; Q9UQ27" "" "" "0" "0" "1.005" "1.099" "1.378" "1.206" "1.199" "2.515" "2.445" "2.546" "7.271" "575.2" "578.2" "632.2" "792.6" "693.4" "689.9" "1446.4" "1406.1" "1464.3" "4182.0" "" "" "" "" "" "" "" "" "" "" "304.6" "320.5" "362.0" "365.0" "375.2" "383.7" "851.2" "767.5" "821.4" "4182.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9139942290346830630" "False" "High" "IsMasterProtein" "P30084" "Enoyl-CoA hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=ECHS1 PE=1 SV=4" "0.000" "False" "48.317" "41" "10" "24" "10" "290" "31.4" "8.07" "63.18" "10" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00378" "1892" "ENSG00000127884" "ECHS1" "hsa:1892; O00739; P30084; Q5VWY1; Q96H54" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Ciliary landscape; Tryptophan metabolism" "Branched-chain amino acid catabolism; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA" "10" "0" "0.975" "0.916" "0.930" "0.980" "0.955" "0.890" "0.894" "0.975" "0.551" "2299.8" "2242.8" "2105.8" "2139.1" "2254.0" "2195.6" "2045.7" "2056.5" "2242.4" "1266.3" "" "" "" "" "" "" "" "" "" "" "1217.7" "1243.5" "1206.0" "985.1" "1219.5" "1221.3" "1204.0" "1122.5" "1257.9" "1266.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5197563919464376950" "False" "High" "IsMasterProtein" "Q9BTC0" "Death-inducer obliterator 1 OS=Homo sapiens OX=9606 GN=DIDO1 PE=1 SV=5" "0.000" "False" "48.098" "6" "13" "14" "13" "2240" "243.7" "7.88" "34.40" "13" "RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00628, Pf07500, Pf07744" "11083" "ENSG00000101191" "DIDO1" "A8MY65; B9EH82; E1P5I1; hsa:11083; O15043; Q3ZTL7; Q3ZTL8; Q4VXS1; Q4VXS2; Q4VXV8; Q4VXV9; Q96D72; Q9BQW0; Q9BTC0; Q9BW03; Q9H4G6; Q9H4G7; Q9NTU8; Q9NUM8; Q9UFB6" "" "" "0" "0" "0.970" "0.996" "1.061" "1.074" "1.032" "1.512" "1.469" "1.486" "1.838" "847.9" "822.6" "844.2" "899.7" "911.0" "875.3" "1282.3" "1245.4" "1260.1" "1558.2" "" "" "" "" "" "" "" "" "" "" "449.0" "456.1" "483.5" "414.4" "492.9" "486.9" "754.7" "679.8" "706.9" "1558.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-165801227635855458" "False" "High" "IsMasterProtein" "Q00839" "Heterogeneous nuclear ribonucleoprotein U OS=Homo sapiens OX=9606 GN=HNRNPU PE=1 SV=6" "0.000" "False" "47.991" "13" "10" "22" "10" "825" "90.5" "6.00" "61.90" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00622, Pf02037, Pf13671" "3192" "ENSG00000153187" "HNRNPU" "hsa:3192; O75507; Q00839; Q8N174; Q96HY9; Q9BQ09" "mRNA processing; lncRNA in canonical Wnt signaling and colorectal cancer" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "4" "0" "0.918" "1.061" "0.995" "0.932" "1.007" "0.828" "0.341" "0.938" "7.882" "749.4" "688.1" "795.4" "745.9" "698.7" "754.8" "620.7" "255.9" "702.6" "5906.5" "" "" "" "" "" "" "" "" "" "" "396.8" "381.5" "455.6" "343.5" "378.0" "419.9" "365.3" "139.7" "394.2" "5906.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1246838135834817893" "False" "High" "IsMasterProtein" "O75362" "Zinc finger protein 217 OS=Homo sapiens OX=9606 GN=ZNF217 PE=1 SV=1" "0.000" "False" "47.630" "13" "12" "14" "12" "1048" "115.2" "8.48" "31.83" "12" "other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "7764" "ENSG00000171940" "ZNF217" "E1P5Y6; hsa:7764; O75362; Q14DB8" "" "Estrogen-dependent gene expression" "1" "0" "0.973" "1.060" "1.020" "1.059" "0.987" "1.086" "1.173" "1.197" "0.916" "968.3" "941.7" "1026.7" "987.9" "1025.4" "955.5" "1051.4" "1135.9" "1159.1" "886.9" "" "" "" "" "" "" "" "" "" "" "512.7" "522.1" "588.0" "454.9" "554.8" "531.5" "618.8" "620.1" "650.2" "886.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1343514979661683430" "False" "High" "IsMasterProtein" "P22234" "Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase OS=Homo sapiens OX=9606 GN=PAICS PE=1 SV=3" "0.000" "False" "47.602" "24" "11" "31" "11" "425" "47.0" "7.23" "89.91" "11" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00731, Pf01259" "10606" "ENSG00000128050" "PAICS" "E9PDH9; hsa:10606; P22234; Q68CQ5" "Metabolic reprogramming in colon cancer" "Purine ribonucleoside monophosphate biosynthesis" "2" "0" "0.948" "0.961" "0.935" "0.982" "0.987" "0.941" "1.023" "0.955" "0.494" "2446.9" "2320.6" "2350.4" "2287.0" "2402.3" "2414.6" "2301.8" "2502.9" "2337.9" "1208.6" "" "" "" "" "" "" "" "" "" "" "1295.6" "1286.6" "1346.1" "1053.2" "1299.7" "1343.1" "1354.7" "1366.2" "1311.5" "1208.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6733467377289635687" "False" "High" "IsMasterProtein" "Q13838" "Spliceosome RNA helicase DDX39B OS=Homo sapiens OX=9606 GN=DDX39B PE=1 SV=1" "0.000" "False" "47.574" "24" "12" "26" "5" "428" "49.0" "5.67" "74.94" "12" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "7919" "ENSG00000198563; ENSG00000215425; ENSG00000225073; ENSG00000225859; ENSG00000229496; ENSG00000230624; ENSG00000235439" "DDX39B" "B0S8C0; hsa:7919; O43496; Q0EFA1; Q13838; Q2L6F9; Q53GL9; Q5RJ64; Q5RJ66; Q5ST94; Q5STB4; Q5STB5; Q5STB7; Q5STB8; Q5STU4; Q5STU5; Q5STU6; Q5STU8; Q71V76" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; RHOBTB2 GTPase cycle" "5" "5" "1.033" "1.000" "1.026" "1.036" "1.039" "1.013" "0.989" "1.023" "1.053" "2806.2" "2898.5" "2804.9" "2880.2" "2908.0" "2916.6" "2842.9" "2776.6" "2870.9" "2953.8" "" "" "" "" "" "" "" "" "" "" "1485.9" "1607.0" "1606.4" "1326.4" "1573.3" "1622.3" "1673.2" "1515.6" "1610.5" "2953.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5974744531153524067" "False" "High" "IsMasterProtein" "Q01581" "Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=HMGCS1 PE=1 SV=2" "0.000" "False" "47.541" "21" "10" "19" "10" "520" "57.3" "5.41" "51.09" "10" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01154, Pf08540" "3157" "ENSG00000112972" "HMGCS1" "B2RDL8; hsa:3157; Q01581" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); PPARA activates gene expression; Cholesterol biosynthesis" "13" "0" "0.981" "1.001" "0.994" "1.004" "1.057" "1.012" "1.010" "0.990" "0.591" "1488.1" "1459.8" "1490.0" "1479.2" "1494.7" "1572.2" "1506.3" "1502.6" "1473.2" "878.8" "" "" "" "" "" "" "" "" "" "" "788.0" "809.3" "853.3" "681.2" "808.7" "874.5" "886.5" "820.2" "826.4" "878.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2015286030572761336" "False" "High" "IsMasterProtein" "P24752" "Acetyl-CoA acetyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAT1 PE=1 SV=1" "0.000" "False" "47.474" "24" "11" "26" "11" "427" "45.2" "8.85" "72.35" "11" "other metabolic processes;stress response;developmental processes;other biological processes" "mitochondrion;ER/Golgi" "other molecular function" "Pf00108, Pf02803" "38" "ENSG00000075239" "ACAT1" "B2R6H1; G3XAB4; hsa:38; P24752; Q96FG8" "Fatty acid beta-oxidation; Tryptophan metabolism; SARS-CoV-2 and COVID-19 pathway" "Branched-chain amino acid catabolism; Mitochondrial protein degradation; Utilization of Ketone Bodies; Synthesis of Ketone Bodies" "7" "0" "0.950" "1.049" "0.948" "0.952" "0.964" "0.938" "0.955" "0.936" "0.539" "2991.6" "2843.0" "3139.6" "2836.7" "2846.6" "2884.4" "2805.1" "2857.2" "2798.7" "1613.1" "" "" "" "" "" "" "" "" "" "" "1584.1" "1576.3" "1798.1" "1306.4" "1540.1" "1604.4" "1650.9" "1559.6" "1570.0" "1613.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-537602968940689111" "False" "High" "IsMasterProtein" "P30153" "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R1A PE=1 SV=4" "0.000" "False" "47.462" "22" "13" "21" "11" "589" "65.3" "5.11" "57.11" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02985" "5518" "ENSG00000105568" "PPP2R1A" "hsa:5518; P30153; Q13773; Q6ICQ3; Q96DH3" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Cyclin A/B1/B2 associated events during G2/M transition; PKR-mediated signaling; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Regulation of TP53 Degradation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Spry regulation of FGF signaling; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Initiation of Nuclear Envelope (NE) Reformation; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; DARPP-32 events; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "50" "2" "0.986" "0.981" "0.950" "0.949" "0.929" "0.953" "0.954" "0.919" "0.591" "2972.1" "2931.7" "2916.0" "2823.2" "2819.8" "2762.5" "2831.2" "2835.7" "2730.7" "1755.9" "" "" "" "" "" "" "" "" "" "" "1573.7" "1625.4" "1670.0" "1300.2" "1525.6" "1536.6" "1666.3" "1547.9" "1531.9" "1755.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3951923410761951319" "False" "High" "IsMasterProtein" "Q9UQ80" "Proliferation-associated protein 2G4 OS=Homo sapiens OX=9606 GN=PA2G4 PE=1 SV=3" "0.000" "False" "47.454" "32" "12" "27" "11" "394" "43.8" "6.55" "59.85" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00557" "5036" "ENSG00000170515" "PA2G4" "hsa:5036; O43846; Q9UM59; Q9UQ80" "" "Neutrophil degranulation" "1" "0" "1.030" "1.013" "1.148" "1.127" "1.127" "1.200" "1.175" "1.069" "0.951" "1446.2" "1490.1" "1465.1" "1659.6" "1629.9" "1630.1" "1735.2" "1698.6" "1545.4" "1374.8" "" "" "" "" "" "" "" "" "" "" "765.8" "826.1" "839.1" "764.3" "881.8" "906.7" "1021.2" "927.2" "867.0" "1374.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3142486401368971215" "False" "High" "IsMasterProtein" "Q3YEC7" "Rab-like protein 6 OS=Homo sapiens OX=9606 GN=RABL6 PE=1 SV=2" "0.000" "False" "47.349" "18" "12" "21" "12" "729" "79.5" "5.22" "54.10" "12" "" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08477" "55684" "ENSG00000196642" "RABL6" "A8QVZ7; A8QVZ8; C6K8I4; C6K8I5; hsa:55684; Q3YEC7; Q4F968; Q5T5R7; Q8IWK1; Q8TCL4; Q8WU94; Q96SR8; Q9BU21; Q9H935" "" "" "0" "0" "1.073" "0.994" "1.040" "1.054" "1.050" "1.048" "1.028" "1.071" "0.834" "1135.1" "1217.5" "1128.2" "1180.3" "1196.1" "1192.0" "1189.5" "1166.9" "1215.7" "946.7" "" "" "" "" "" "" "" "" "" "" "601.0" "675.0" "646.1" "543.6" "647.1" "663.0" "700.0" "637.0" "682.0" "946.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8431694603937659134" "False" "High" "IsMasterProtein" "P15531" "Nucleoside diphosphate kinase A OS=Homo sapiens OX=9606 GN=NME1 PE=1 SV=1" "0.000" "False" "47.333" "57" "8" "55" "4" "152" "17.1" "6.19" "157.23" "8" "DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "translation activity;kinase activity;other molecular function" "Pf00334" "4830" "ENSG00000239672" "NME1" "hsa:4830; P15531; Q6FGK3; Q86XQ2; Q9UDJ6" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates; Azathioprine ADME; Ribavirin ADME" "4" "0" "0.936" "0.926" "0.965" "0.981" "1.013" "1.011" "1.021" "1.165" "0.565" "2057.9" "1926.6" "1905.6" "1986.1" "2018.1" "2085.5" "2080.7" "2101.7" "2396.5" "1163.5" "" "" "" "" "" "" "" "" "" "" "1089.6" "1068.2" "1091.3" "914.6" "1091.9" "1160.1" "1224.6" "1147.2" "1344.4" "1163.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8210818149912646419" "False" "High" "IsMasterProtein" "P11216" "Glycogen phosphorylase, brain form OS=Homo sapiens OX=9606 GN=PYGB PE=1 SV=5" "0.000" "False" "47.316" "14" "12" "16" "12" "843" "96.6" "6.86" "45.33" "12" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00343" "5834" "ENSG00000100994" "PYGB" "hsa:5834; P11216; Q96AK1; Q9NPX8" "IL-18 signaling pathway; Glycogen synthesis and degradation" "Neutrophil degranulation; Glycogen breakdown (glycogenolysis)" "4" "0" "1.001" "0.975" "1.014" "0.990" "1.021" "1.048" "1.067" "0.948" "0.678" "1554.8" "1555.8" "1516.3" "1576.7" "1539.0" "1586.8" "1629.7" "1659.4" "1473.3" "1054.8" "" "" "" "" "" "" "" "" "" "" "823.3" "862.6" "868.4" "726.1" "832.7" "882.6" "959.1" "905.8" "826.5" "1054.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4804495115062908755" "False" "High" "IsMasterProtein" "P41252" "Isoleucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=IARS1 PE=1 SV=2" "0.000" "False" "46.948" "10" "12" "15" "12" "1262" "144.4" "6.15" "44.42" "12" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00133, Pf08264, Pf19302" "3376" "ENSG00000196305; ENSG00000291356" "IARS1" "A8KAE9; hsa:3376; P41252; Q5TCD0; Q7Z3T4; Q9H588" "Amino acid metabolism" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "3" "0" "0.999" "0.959" "1.035" "1.087" "0.993" "0.972" "0.776" "0.945" "2.810" "777.9" "776.7" "745.7" "805.4" "845.4" "772.7" "755.8" "604.0" "735.0" "2185.8" "" "" "" "" "" "" "" "" "" "" "411.9" "430.6" "427.1" "370.9" "457.4" "429.8" "444.8" "329.7" "412.3" "2185.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2009427819375188157" "False" "High" "IsMasterProtein" "P62333" "26S proteasome regulatory subunit 10B OS=Homo sapiens OX=9606 GN=PSMC6 PE=1 SV=1" "0.000" "False" "46.765" "27" "10" "14" "10" "389" "44.1" "7.49" "36.69" "10" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5706" "ENSG00000100519" "PSMC6" "B2R975; hsa:5706; P49719; P62333; Q6IBU3; Q92524" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "Ub-specific processing proteases; The role of GTSE1 in G2/M progression after G2 checkpoint; Antigen processing: Ubiquitination & Proteasome degradation; RUNX1 regulates transcription of genes involved in differentiation of HSCs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; SARS-CoV-1 targets host intracellular signalling and regulatory pathways" "65" "0" "0.973" "1.001" "1.063" "1.043" "1.021" "0.909" "0.902" "0.850" "0.640" "1587.1" "1544.8" "1588.2" "1687.4" "1655.5" "1620.9" "1443.3" "1431.9" "1349.1" "1015.3" "" "" "" "" "" "" "" "" "" "" "840.4" "856.5" "909.6" "777.1" "895.7" "901.6" "849.4" "781.6" "756.8" "1015.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4642544614061212331" "False" "High" "IsMasterProtein" "P38159" "RNA-binding motif protein, X chromosome OS=Homo sapiens OX=9606 GN=RBMX PE=1 SV=3" "0.000" "False" "46.745" "37" "16" "24" "6" "391" "42.3" "10.05" "57.21" "16" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08081" "27316" "ENSG00000147274" "RBMX" "B4E3U4; D3DWH0; E9PG86; hsa:27316; P38159; Q5JQ67; Q8N8Y7; Q969R3" "mRNA processing" "mRNA Splicing - Major Pathway; RND2 GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Processing of Capped Intron-Containing Pre-mRNA; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "8" "7" "0.959" "1.037" "1.220" "1.221" "1.187" "2.077" "2.196" "2.097" "0.904" "1872.2" "1795.2" "1941.7" "2283.4" "2286.5" "2222.7" "3887.8" "4110.8" "3926.4" "1691.6" "" "" "" "" "" "" "" "" "" "" "991.3" "995.3" "1112.0" "1051.6" "1237.1" "1236.4" "2288.1" "2243.9" "2202.6" "1691.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7657012177295081485" "False" "High" "IsMasterProtein" "O43684" "Mitotic checkpoint protein BUB3 OS=Homo sapiens OX=9606 GN=BUB3 PE=1 SV=1" "0.000" "False" "46.736" "30" "8" "17" "8" "328" "37.1" "6.84" "47.66" "8" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "9184" "ENSG00000154473" "BUB3" "A6NJ42; B2R6E7; D3DRE9; hsa:9184; O43684; O43685" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A" "12" "0" "0.997" "0.955" "1.014" "1.021" "0.959" "1.030" "0.986" "0.996" "0.621" "1116.7" "1113.9" "1065.9" "1131.9" "1140.3" "1071.3" "1150.2" "1101.4" "1112.7" "694.0" "" "" "" "" "" "" "" "" "" "" "591.3" "617.6" "610.5" "521.3" "617.0" "595.9" "676.9" "601.2" "624.2" "694.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4943408873611006946" "False" "High" "IsMasterProtein" "Q02790" "Peptidyl-prolyl cis-trans isomerase FKBP4 OS=Homo sapiens OX=9606 GN=FKBP4 PE=1 SV=3" "0.000" "False" "46.642" "29" "13" "21" "13" "459" "51.8" "5.43" "59.92" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00254, Pf00515" "2288" "ENSG00000004478" "FKBP4" "D3DUQ1; hsa:2288; Q02790; Q9UCP1; Q9UCV7" "Androgen receptor signaling pathway" "Estrogen-dependent gene expression; Potential therapeutics for SARS; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase" "6" "0" "0.971" "0.926" "1.004" "1.035" "1.010" "1.000" "0.723" "0.966" "3.569" "1583.0" "1537.1" "1465.2" "1589.9" "1638.4" "1599.3" "1583.4" "1144.1" "1528.9" "5650.0" "" "" "" "" "" "" "" "" "" "" "838.2" "852.2" "839.1" "732.2" "886.5" "889.6" "931.9" "624.5" "857.7" "5650.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5135985212415519925" "False" "High" "IsMasterProtein" "P43686" "26S proteasome regulatory subunit 6B OS=Homo sapiens OX=9606 GN=PSMC4 PE=1 SV=2" "0.000" "False" "46.539" "29" "13" "21" "13" "418" "47.3" "5.21" "65.28" "13" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5704" "ENSG00000013275; ENSG00000281221" "PSMC4" "hsa:5704; P43686; Q96FV5; Q9UBM3; Q9UEX3" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "Assembly of the pre-replicative complex; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "1.048" "1.094" "1.021" "1.111" "1.128" "0.971" "0.999" "0.974" "0.731" "1209.9" "1268.6" "1323.7" "1235.8" "1344.1" "1364.5" "1175.2" "1208.8" "1177.9" "884.2" "" "" "" "" "" "" "" "" "" "" "640.7" "703.3" "758.1" "569.1" "727.2" "759.0" "691.7" "659.8" "660.8" "884.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-644721245290312006" "False" "High" "IsMasterProtein" "Q9UNS2" "COP9 signalosome complex subunit 3 OS=Homo sapiens OX=9606 GN=COPS3 PE=1 SV=3" "0.000" "False" "46.509" "26" "10" "22" "10" "423" "47.8" "6.65" "44.17" "10" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01399, Pf21215" "8533" "ENSG00000141030" "COPS3" "B2R683; B4DY81; hsa:8533; O43191; Q7LDR6; Q9UNS2" "Ciliary landscape; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Neddylation; Formation of TC-NER Pre-Incision Complex; Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER" "6" "0" "0.976" "0.978" "0.971" "0.965" "1.071" "1.014" "1.040" "0.989" "0.618" "1982.4" "1934.9" "1939.7" "1925.0" "1913.3" "2123.2" "2010.2" "2061.6" "1960.4" "1224.9" "" "" "" "" "" "" "" "" "" "" "1049.7" "1072.8" "1110.9" "886.5" "1035.2" "1181.0" "1183.1" "1125.3" "1099.7" "1224.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7688952667704275831" "False" "High" "IsMasterProtein" "O14818" "Proteasome subunit alpha type-7 OS=Homo sapiens OX=9606 GN=PSMA7 PE=1 SV=1" "0.000" "False" "46.476" "36" "10" "24" "8" "248" "27.9" "8.46" "64.70" "10" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf10584" "5688" "ENSG00000101182" "PSMA7" "B2R515; hsa:5688; O14818; Q5JXJ2; Q9BR53; Q9H4K5; Q9UEU8" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "2" "0.961" "0.989" "0.934" "0.939" "0.934" "1.048" "0.985" "0.984" "0.551" "2361.4" "2268.9" "2335.2" "2205.7" "2217.4" "2206.2" "2473.6" "2326.7" "2323.8" "1302.2" "" "" "" "" "" "" "" "" "" "" "1250.4" "1258.0" "1337.4" "1015.8" "1199.7" "1227.2" "1455.8" "1270.0" "1303.6" "1302.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6590851508053806454" "False" "High" "IsMasterProtein" "Q9BQ52" "Zinc phosphodiesterase ELAC protein 2 OS=Homo sapiens OX=9606 GN=ELAC2 PE=1 SV=2" "0.000" "False" "46.404" "17" "12" "18" "12" "826" "92.2" "7.90" "48.74" "12" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf12706, Pf13691" "60528" "ENSG00000006744" "ELAC2" "B4DPL9; hsa:60528; Q6IA94; Q9BQ52; Q9HAS8; Q9HAS9; Q9NVT1" "" "tRNA processing in the nucleus; tRNA processing in the mitochondrion; rRNA processing in the mitochondrion; tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis" "4" "0" "1.002" "0.996" "1.032" "1.025" "0.985" "1.089" "1.054" "0.970" "0.614" "1398.5" "1401.3" "1393.1" "1443.2" "1433.5" "1377.7" "1522.4" "1473.7" "1356.5" "858.5" "" "" "" "" "" "" "" "" "" "" "740.5" "776.9" "797.8" "664.6" "775.6" "766.4" "896.0" "804.4" "761.0" "858.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "92352165089450524" "False" "High" "IsMasterProtein" "O15355" "Protein phosphatase 1G OS=Homo sapiens OX=9606 GN=PPM1G PE=1 SV=1" "0.000" "False" "46.378" "19" "9" "17" "9" "546" "59.2" "4.36" "44.55" "9" "protein metabolism;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf00481" "5496" "ENSG00000115241" "PPM1G" "hsa:5496; O15355" "VEGFA-VEGFR2 signaling; mRNA processing" "" "2" "0" "1.076" "0.930" "1.164" "1.121" "0.960" "1.278" "0.883" "1.321" "6.878" "414.6" "445.9" "385.7" "482.7" "464.7" "398.2" "530.0" "366.1" "547.8" "2851.5" "" "" "" "" "" "" "" "" "" "" "219.5" "247.2" "220.9" "222.3" "251.4" "221.5" "311.9" "199.8" "307.3" "2851.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6626039175338175676" "False" "High" "IsMasterProtein" "Q9NXH9" "tRNA (guanine(26)-N(2))-dimethyltransferase OS=Homo sapiens OX=9606 GN=TRMT1 PE=1 SV=1" "0.000" "False" "46.296" "15" "9" "16" "9" "659" "72.2" "7.64" "46.62" "9" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00642, Pf02005" "55621" "ENSG00000104907" "TRMT1" "hsa:55621; O76103; Q548Y5; Q8WVA6; Q9NXH9" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.991" "0.959" "1.022" "1.008" "0.934" "0.964" "0.996" "0.964" "0.532" "1217.2" "1206.3" "1167.3" "1243.4" "1226.7" "1137.4" "1173.9" "1212.6" "1172.9" "647.5" "" "" "" "" "" "" "" "" "" "" "644.5" "668.8" "668.5" "572.6" "663.7" "632.7" "690.9" "661.9" "658.0" "647.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8957423501143175457" "False" "High" "IsMasterProtein" "Cont_P81948" "Tubulin alpha-4A chain OS=Bos taurus OX=9913 GN=TUBA4A PE=1 SV=2" "0.000" "True" "46.290" "25" "10" "28" "2" "448" "49.9" "5.06" "80.21" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "100151951; 100302357; 100354352; 100400294; 100449357; 100734500; 100767686; 100995882; 101006121; 101095277; 101148853; 101379814; 101569770; 101606396; 101677236; 101838478; 101926805; 101969889; 102012828; 102177846; 102532857; 102746509; 102841369; 102928867; 102962068; 103007004; 103072784; 103110543; 103217904; 103261248; 103662744; 103727749; 104660054; 105064041; 105481257; 105504700; 105528059; 105587029; 105808789; 105857673; 105996598; 107138719; 107516732; 109265033; 109571050; 22145; 316531; 470654; 478918; 702583; 7277; 777775" "ENSANAG00000028048; ENSBIXG00005021445; ENSBMSG00010001061; ENSBTAG00000030974; ENSCAFG00000015209; ENSCAFG00020027000; ENSCAFG00030011006; ENSCAFG00845029842; ENSCANG00000024607; ENSCATG00000033332; ENSCGRG00001024425; ENSCHIG00000002435; ENSCJAG00000070762; ENSCLAG00000011603; ENSCPOG00000037151; ENSCSAG00000008100; ENSFCAG00000038881; ENSG00000127824; ENSGGOG00000023578; ENSJJAG00000011005; ENSLCNG00005009789; ENSMFAG00000007541; ENSMICG00000035827; ENSMLEG00000029671; ENSMMMG00000020450; ENSMMSG00000019327; ENSMMUG00000019628; ENSMNEG00000039170; ENSMSIG00000018170; ENSMUSG00000026202; ENSNGAG00000020443; ENSNLEG00000027445; ENSOARG00000020020; ENSOCUG00000026994; ENSPANG00000041659; ENSPCOG00000023925; ENSPEMG00000029240; ENSPLOG00000016209; ENSPPAG00000011142; ENSPPYG00000013203; ENSPSMG00000025346; ENSPSNG00000018656; ENSPTEG00000039375; ENSPTIG00000021758; ENSPTRG00000012949; ENSRNOG00000003597; ENSRNOG00055010434; ENSRNOG00060007884; ENSRNOG00065008885; ENSRROG00000044949; ENSSSCG00000016216; ENSSSCG00025016272; ENSSSCG00035020742; ENSSSCG00040017674; ENSSSCG00050039745; ENSSSCG00070016481; ENSSTOG00000019497; ENSSVLG00005016017; ENSTGEG00000012532; ENSTSYG00000011750; ENSUMAG00000018763; ENSUPAG00010012836; ENSVVUG00000025771" "LOC101334183; LOC102532857; LOC102746509; LOC103662744; LOC106970047; LOC109265033; LOC111143142; LOC111171848; LOC112411846; LOC112838391; LOC112872268; LOC112922524; LOC113920876; LOC114495658; LOC118898366; Tuba4a; TUBA4A" "A0A0D9R6X5; A0A1S2ZI83; A0A1S3GBQ2; A0A1U7Q653; A0A1U7TVH0; A0A286ZNY1; A0A2I2UZ20; A0A2I2YM80; A0A2J8NG28; A0A2J8TUH3; A0A2K5DHU1; A0A2K5HTH7; A0A2K5M1H8; A0A2K5Y6I3; A0A2K6D749; A0A2K6GBF8; A0A2K6RS93; A0A2R8ZC21; A0A2U3W3Z0; A0A2U3YH71; A0A2Y9IV09; A0A2Y9N2F1; A0A340WE79; A0A341CW34; A0A384AKZ1; A0A384C1E6; A0A3Q7QMN7; A0A3Q7SCG6; A0A452DNE3; A0A484GTP9; A0A485MVS4; A0A4W2GGR2; A0A4X1UG19; A0A5N3WUA1; A0A663D8Z2; A0A667GI79; A0A6D2XJT6; A0A6I9I9T5; A0A6I9L693; A0A6J1YN80; A0A6J2LL95; A0A6J3RLQ7; A0A6P3CX09; A0A6P3FIC2; A0A6P5D399; A0A6P6ISG9; A0A6P9F8Q5; A0A7J8JNJ1; A0A811ZBS6; A0A8B7EMV4; A0A8B7KBC2; A0A8B8XXA4; A0A8C0LT90; A0A8C0MZ87; A0A8C2N284; A0A8C2VS48; A0A8C5KB95; A0A8C6E681; A0A8C6EXI3; A0A8C6HJF8; A0A8C6RPC4; A0A8C8XN00; A0A8C9ASB4; A0A8C9CIF4; A0A8C9IX37; A0A8C9KT44; A0A8D2D621; A0A8D2K0Z6; A0A8D2KIE8; A0A8I3Q1H9; A0A8I5NZD6; A0A8U0N0J8; A0A9B0TPY2; A0A9V1FEX0; A0A9W3GNM5; A6JVZ9; A8MUB1; aju:106970047; B3KNQ6; biu:109571050; bta:777775; C5ISA2; caty:105587029; cfr:102522237; chx:102177846; cjc:100400294; cpoc:100734500; csyr:103261248; dle:111171848; dord:105996598; elk:111143142; F6QRE8; F7HZP3; fca:101095277; G1RDQ0; G1TR82; H0V3I8; H2P8P0; H2QJG6; hsa:7277; I3NHW3; K9IKB3; lww:102746509; maua:101838478; mcf:101926805; mmu:22145; mmur:105857673; mpuf:101677236; nasi:112411846; ngi:103727749; oas:100302357; ocu:100354352; oro:101379814; P05215; P68366; P68367; P68368; P81948; panu:101006121; pcoo:112872268; pdic:114495658; pon:100449357; pps:100995882; ptg:102962068; Q17QT1; Q3TY31; Q5E986; Q5XIF6; ray:107516732; rno:316531; rro:104660054; ssc:100151951; umr:103662744; vpc:102532857; vvp:112922524" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease; HDAC6 interactions in the central nervous system" "Platelet degranulation ; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Intraflagellar transport; COPI-mediated anterograde transport; The role of GTSE1 in G2/M progression after G2 checkpoint; Carboxyterminal post-translational modifications of tubulin; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; PKR-mediated signaling; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; RHO GTPases Activate Formins; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Platelet degranulation ; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state; Platelet degranulation ; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; MHC class II antigen presentation; COPI-mediated anterograde transport; Separation of Sister Chromatids; Anchoring of the basal body to the plasma membrane; PKR-mediated signaling; Resolution of Sister Chromatid Cohesion; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; AURKA Activation by TPX2; EML4 and NUDC in mitotic spindle formation; Intraflagellar transport; Carboxyterminal post-translational modifications of tubulin; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recycling pathway of L1; Hedgehog 'off' state; RHO GTPases activate IQGAPs; COPI-independent Golgi-to-ER retrograde traffic; The role of GTSE1 in G2/M progression after G2 checkpoint; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Platelet degranulation ; COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; Resolution of Sister Chromatid Cohesion; Regulation of PLK1 Activity at G2/M Transition; The role of GTSE1 in G2/M progression after G2 checkpoint; MHC class II antigen presentation; RHO GTPases Activate Formins; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; Intraflagellar transport; Separation of Sister Chromatids; EML4 and NUDC in mitotic spindle formation; Hedgehog 'off' state; Loss of Nlp from mitotic centrosomes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Kinesins; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; RHO GTPases activate IQGAPs; Carboxyterminal post-translational modifications of tubulin; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; MHC class II antigen presentation; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; COPI-independent Golgi-to-ER retrograde traffic; Anchoring of the basal body to the plasma membrane; Platelet degranulation ; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; COPI-dependent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Kinesins; PKR-mediated signaling; COPI-mediated anterograde transport; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; Hedgehog 'off' state; Intraflagellar transport; Carboxyterminal post-translational modifications of tubulin; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Sealing of the nuclear envelope (NE) by ESCRT-III; Aggrephagy; Recycling pathway of L1; RHO GTPases activate IQGAPs; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane" "160" "0" "1.048" "0.946" "0.925" "0.915" "0.972" "0.735" "0.849" "0.797" "0.653" "304.2" "318.8" "287.9" "281.4" "278.2" "295.6" "223.7" "258.2" "242.4" "198.7" "" "" "" "" "" "" "" "" "" "" "161.1" "176.7" "164.9" "129.6" "150.5" "164.4" "131.6" "140.9" "136.0" "198.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2982172693089125932" "False" "High" "IsMasterProtein" "P28066" "Proteasome subunit alpha type-5 OS=Homo sapiens OX=9606 GN=PSMA5 PE=1 SV=3" "0.000" "False" "46.173" "32" "6" "14" "6" "241" "26.4" "4.79" "49.47" "6" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00227, Pf10584" "5686" "ENSG00000143106" "PSMA5" "B2R8F6; B4E2V4; hsa:5686; P28066; Q3T1C1; Q6IBF7" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Downstream TCR signaling; UCH proteinases; Separation of Sister Chromatids; Neutrophil degranulation; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "0.965" "0.940" "0.966" "0.993" "0.994" "1.065" "1.016" "1.015" "0.531" "1321.9" "1275.4" "1242.5" "1276.4" "1312.7" "1314.3" "1407.5" "1343.7" "1341.8" "701.9" "" "" "" "" "" "" "" "" "" "" "699.9" "707.1" "711.6" "587.8" "710.2" "731.1" "828.3" "733.4" "752.7" "701.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5870318523395655526" "False" "High" "IsMasterProtein" "P49591" "Serine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=SARS1 PE=1 SV=3" "0.000" "False" "46.129" "23" "11" "16" "11" "514" "58.7" "6.43" "49.35" "11" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00587, Pf02403" "6301" "ENSG00000031698" "SARS1" "B2R6Y9; hsa:6301; P49591; Q5T5C8; Q9NSE3" "VEGFA-VEGFR2 signaling" "Cytosolic tRNA aminoacylation; Selenocysteine synthesis" "3" "0" "0.979" "0.941" "0.996" "0.992" "1.014" "0.928" "0.944" "0.919" "0.549" "1652.1" "1618.2" "1554.2" "1646.2" "1638.9" "1675.4" "1533.1" "1560.1" "1519.0" "907.5" "" "" "" "" "" "" "" "" "" "" "874.8" "897.2" "890.1" "758.1" "886.7" "931.9" "902.3" "851.6" "852.1" "907.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6313231503744566384" "False" "High" "IsMasterProtein" "O00754" "Lysosomal alpha-mannosidase OS=Homo sapiens OX=9606 GN=MAN2B1 PE=1 SV=3" "0.000" "False" "46.099" "12" "12" "22" "12" "1011" "113.7" "7.28" "59.18" "12" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01074, Pf07748, Pf09261, Pf21260" "4125" "ENSG00000104774" "MAN2B1" "G5E928; hsa:4125; O00754; O15330; Q16680; Q93094; Q9BW13" "" "Neutrophil degranulation; Lysosomal oligosaccharide catabolism" "2" "0" "0.966" "1.023" "0.939" "1.014" "0.948" "0.984" "0.989" "0.881" "0.487" "1392.2" "1344.6" "1423.5" "1307.2" "1412.4" "1319.9" "1369.3" "1377.1" "1227.1" "678.1" "" "" "" "" "" "" "" "" "" "" "737.2" "745.5" "815.2" "602.0" "764.1" "734.2" "805.9" "751.7" "688.4" "678.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8925362845928829320" "False" "High" "IsMasterProtein" "Q12996" "Cleavage stimulation factor subunit 3 OS=Homo sapiens OX=9606 GN=CSTF3 PE=1 SV=1" "0.000" "False" "46.027" "13" "9" "13" "9" "717" "82.9" "8.12" "41.80" "9" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf05843" "1479" "ENSG00000176102" "CSTF3" "A8K471; D3DR04; E9PB40; hsa:1479; Q12996; Q32P22; Q96FQ8; Q96QD6; Q96QK4" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "1.021" "0.986" "1.053" "1.070" "0.996" "1.088" "1.072" "1.103" "0.781" "954.1" "973.8" "940.4" "1004.5" "1021.4" "950.1" "1037.6" "1023.2" "1052.0" "745.3" "" "" "" "" "" "" "" "" "" "" "505.2" "539.9" "538.6" "462.6" "552.6" "528.5" "610.7" "558.5" "590.2" "745.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-154520297388586765" "False" "High" "IsMasterProtein" "Q9HCC0" "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial OS=Homo sapiens OX=9606 GN=MCCC2 PE=1 SV=1" "0.000" "False" "45.998" "17" "10" "15" "10" "563" "61.3" "7.68" "45.13" "10" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf01039" "64087" "ENSG00000131844" "MCCC2" "A6NIY9; hsa:64087; Q96C27; Q9HCC0; Q9Y4L7" "" "Biotin transport and metabolism; Branched-chain amino acid catabolism; Defective HLCS causes multiple carboxylase deficiency" "3" "0" "0.940" "0.964" "0.872" "0.968" "0.969" "0.966" "0.967" "1.027" "0.615" "2067.4" "1943.7" "1993.6" "1802.1" "2002.1" "2004.3" "1997.9" "1999.0" "2122.4" "1271.6" "" "" "" "" "" "" "" "" "" "" "1094.7" "1077.7" "1141.7" "829.9" "1083.2" "1114.9" "1175.9" "1091.2" "1190.6" "1271.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2598946853791074460" "False" "High" "IsMasterProtein" "Q9Y295" "Developmentally-regulated GTP-binding protein 1 OS=Homo sapiens OX=9606 GN=DRG1 PE=1 SV=1" "0.000" "False" "45.894" "22" "8" "22" "7" "367" "40.5" "8.90" "59.55" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01926, Pf02824, Pf16897" "4733" "ENSG00000185721" "DRG1" "B2RDS8; hsa:4733; Q6FGP8; Q8WW69; Q9UGF2; Q9Y295" "" "Protein hydroxylation" "1" "1" "1.002" "0.993" "0.910" "0.925" "0.956" "0.900" "0.963" "0.913" "0.670" "1192.7" "1194.9" "1184.5" "1085.4" "1103.2" "1140.5" "1073.8" "1149.1" "1088.8" "799.3" "" "" "" "" "" "" "" "" "" "" "631.6" "662.5" "678.4" "499.9" "596.9" "634.4" "632.0" "627.2" "610.8" "799.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2666399162137355267" "False" "High" "IsMasterProtein" "P38117" "Electron transfer flavoprotein subunit beta OS=Homo sapiens OX=9606 GN=ETFB PE=1 SV=3" "0.000" "False" "45.874" "38" "10" "28" "10" "255" "27.8" "8.10" "79.57" "10" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01012" "2109" "ENSG00000105379" "ETFB" "A8K766; B3KNY2; hsa:2109; P38117; Q6IBH7; Q71RF6; Q9Y3S7" "" "Respiratory electron transport; Protein methylation" "2" "0" "1.050" "1.039" "1.074" "1.026" "0.995" "0.959" "0.950" "0.830" "0.583" "1795.8" "1886.0" "1865.7" "1928.0" "1842.6" "1786.4" "1721.7" "1706.1" "1491.1" "1047.5" "" "" "" "" "" "" "" "" "" "" "950.9" "1045.7" "1068.5" "887.9" "996.9" "993.7" "1013.3" "931.3" "836.5" "1047.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "479686062085054609" "False" "High" "IsMasterProtein" "Q15365" "Poly(rC)-binding protein 1 OS=Homo sapiens OX=9606 GN=PCBP1 PE=1 SV=2" "0.000" "False" "45.691" "29" "8" "12" "4" "356" "37.5" "7.09" "34.96" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013" "5093" "ENSG00000169564" "PCBP1" "hsa:5093; Q13157; Q14975; Q15365" "Ferroptosis" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "3" "3" "1.145" "1.037" "1.136" "1.094" "1.083" "1.290" "1.115" "1.204" "2.245" "678.4" "776.5" "703.4" "770.7" "742.5" "734.7" "875.0" "756.3" "816.6" "1523.3" "" "" "" "" "" "" "" "" "" "" "359.2" "430.5" "402.9" "354.9" "401.7" "408.7" "515.0" "412.8" "458.1" "1523.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5986296192720168781" "False" "High" "IsMasterProtein" "Q9Y617" "Phosphoserine aminotransferase OS=Homo sapiens OX=9606 GN=PSAT1 PE=1 SV=2" "0.000" "False" "45.637" "29" "12" "19" "12" "370" "40.4" "7.66" "55.27" "12" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00266" "29968" "ENSG00000135069" "PSAT1" "hsa:29968; Q5T7G5; Q5T7G6; Q96AW2; Q9BQ12; Q9Y617" "Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Male infertility; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells" "Serine biosynthesis" "7" "0" "0.988" "0.985" "1.090" "0.979" "1.036" "1.028" "1.076" "0.975" "0.568" "1287.3" "1271.4" "1267.9" "1402.8" "1259.7" "1334.3" "1323.7" "1385.4" "1255.5" "731.2" "" "" "" "" "" "" "" "" "" "" "681.6" "704.9" "726.1" "646.0" "681.6" "742.2" "779.0" "756.3" "704.3" "731.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4754969911618934256" "False" "High" "IsMasterProtein" "Q5H9R7" "Serine/threonine-protein phosphatase 6 regulatory subunit 3 OS=Homo sapiens OX=9606 GN=PPP6R3 PE=1 SV=2" "0.000" "False" "45.548" "15" "11" "14" "11" "873" "97.6" "4.60" "39.97" "11" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf04499" "55291" "ENSG00000110075" "PPP6R3" "hsa:55291; Q3B7I1; Q3I4Y0; Q3KR35; Q5H9R7; Q68CR3; Q7L4R8; Q8N3B2; Q96MB2; Q9H2K5; Q9H2K6; Q9HCL4; Q9NUY3" "" "Telomere Extension By Telomerase; COPII-mediated vesicle transport" "2" "0" "0.988" "1.025" "0.855" "0.936" "0.947" "0.843" "0.888" "0.876" "0.674" "1152.2" "1137.8" "1180.7" "984.5" "1078.7" "1091.0" "971.0" "1023.4" "1009.4" "776.5" "" "" "" "" "" "" "" "" "" "" "610.1" "630.8" "676.2" "453.4" "583.6" "606.9" "571.5" "558.6" "566.3" "776.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7543503445909431130" "False" "High" "IsMasterProtein" "P13798" "Acylamino-acid-releasing enzyme OS=Homo sapiens OX=9606 GN=APEH PE=1 SV=4" "0.000" "False" "45.502" "12" "9" "21" "9" "732" "81.2" "5.48" "66.80" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00326, Pf19283" "327" "ENSG00000164062" "APEH" "hsa:327; P13798; Q9BQ33; Q9P0Y2" "" "Neutrophil degranulation; Eukaryotic Translation Termination" "2" "0" "0.979" "0.939" "0.911" "0.959" "0.984" "1.044" "0.919" "0.998" "0.855" "2353.0" "2302.7" "2209.6" "2142.6" "2257.3" "2314.5" "2457.6" "2163.1" "2349.1" "2011.0" "" "" "" "" "" "" "" "" "" "" "1245.9" "1276.7" "1265.4" "986.8" "1221.3" "1287.4" "1446.4" "1180.8" "1317.8" "2011.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8048199414682788645" "False" "High" "IsMasterProtein" "Q06323" "Proteasome activator complex subunit 1 OS=Homo sapiens OX=9606 GN=PSME1 PE=1 SV=1" "0.000" "False" "45.398" "33" "8" "27" "8" "249" "28.7" "6.02" "75.22" "8" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf02251, Pf02252" "5720" "ENSG00000092010; ENSG00000284916" "PSME1" "A6NJG9; H0YNE3; hsa:5720; Q06323; Q6IBM2; Q9UEF4" "Proteasome degradation" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "60" "0" "1.186" "1.180" "0.865" "0.958" "1.046" "1.075" "1.380" "1.402" "0.607" "3155.3" "3742.6" "3722.8" "2729.8" "3023.1" "3301.4" "3393.2" "4354.5" "4423.3" "1914.2" "" "" "" "" "" "" "" "" "" "" "1670.7" "2075.0" "2132.0" "1257.1" "1635.6" "1836.4" "1997.0" "2376.9" "2481.4" "1914.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4137666002023082164" "False" "High" "IsMasterProtein" "Cont_P00761" "Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1" "0.000" "True" "45.396" "29" "5" "53" "5" "231" "24.4" "7.18" "171.13" "5" "protein metabolism;other biological processes" "non-structural extracellular" "other molecular function" "Pf00089" "" "" "" "" "" "" "0" "0" "0.997" "1.011" "1.156" "0.961" "0.863" "0.905" "0.943" "0.866" "0.635" "4342.3" "4331.3" "4391.3" "5020.1" "4174.9" "3745.9" "3927.7" "4092.7" "3762.0" "2758.8" "" "" "" "" "" "" "" "" "" "" "2299.3" "2401.4" "2514.9" "2311.9" "2258.8" "2083.7" "2311.6" "2234.0" "2110.4" "2758.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-154777414140805672" "False" "High" "IsMasterProtein" "P20810" "Calpastatin OS=Homo sapiens OX=9606 GN=CAST PE=1 SV=4" "0.000" "False" "45.335" "16" "10" "18" "10" "708" "76.5" "5.07" "52.46" "10" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity" "Pf00748" "831" "ENSG00000153113" "CAST" "B7Z468; G5E946; G5E9D3; hsa:831; O95360; P20810; Q05DE8; Q7Z4K0; Q96D08; Q9H1Z5" "" "Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "2" "0" "0.988" "1.007" "1.031" "0.989" "0.915" "1.010" "0.992" "0.954" "0.491" "1960.1" "1937.4" "1974.4" "2020.0" "1937.9" "1793.6" "1978.8" "1944.9" "1870.4" "962.1" "" "" "" "" "" "" "" "" "" "" "1037.9" "1074.1" "1130.7" "930.3" "1048.5" "997.7" "1164.6" "1061.6" "1049.2" "962.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5215357132518723376" "False" "High" "IsMasterProtein" "P30040" "Endoplasmic reticulum resident protein 29 OS=Homo sapiens OX=9606 GN=ERP29 PE=1 SV=4" "0.000" "False" "45.326" "28" "6" "24" "6" "261" "29.0" "7.31" "61.58" "6" "protein metabolism;other metabolic processes;transport;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf07749, Pf07912" "10961" "ENSG00000089248" "ERP29" "C9J183; hsa:10961; P30040; Q3MJC3; Q6FHT4" "" "" "0" "0" "1.093" "0.988" "1.008" "1.079" "1.039" "0.971" "1.026" "1.038" "0.675" "1303.3" "1423.9" "1287.2" "1313.2" "1406.7" "1353.5" "1265.3" "1337.6" "1353.1" "879.6" "" "" "" "" "" "" "" "" "" "" "690.1" "789.5" "737.2" "604.8" "761.1" "752.9" "744.7" "730.2" "759.1" "879.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4858909322532710110" "False" "High" "IsMasterProtein" "Q16881" "Thioredoxin reductase 1, cytoplasmic OS=Homo sapiens OX=9606 GN=TXNRD1 PE=1 SV=3" "0.000" "False" "45.325" "17" "10" "21" "10" "649" "70.9" "7.39" "56.84" "10" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00462, Pf02852, Pf07992" "7296" "ENSG00000198431" "TXNRD1" "B7Z1F4; B7Z3Y8; B7Z904; E9PMY9; F5H780; hsa:7296; Q16881; Q6FI31; Q6VB40; Q6VB41; Q6VB42; Q6VBP2; Q6VBP3; Q6VBP4; Q6VBP5; Q6VBP9; Q6VBQ0; Q6YNQ1; Q76P53; Q7LA96; Q8WVC8; Q99475; Q9UES8; Q9UH79" "Selenium micronutrient network; Selenium micronutrient network ; Selenium micronutrient network; Selenium metabolism and selenoproteins; Nuclear receptors meta-pathway; NRF2 pathway; Oxidative stress response; Ferroptosis" "Detoxification of Reactive Oxygen Species; PPARA activates gene expression; TP53 Regulates Metabolic Genes; Interconversion of nucleotide di- and triphosphates; NFE2L2 regulating anti-oxidant/detoxification enzymes; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se; Uptake and function of diphtheria toxin; Metabolism of ingested MeSeO2H into MeSeH" "16" "0" "1.006" "0.988" "1.049" "1.010" "1.089" "1.018" "1.056" "0.966" "0.618" "2004.1" "2015.9" "1979.9" "2101.7" "2023.3" "2183.3" "2039.3" "2116.5" "1935.6" "1238.2" "" "" "" "" "" "" "" "" "" "" "1061.2" "1117.7" "1133.9" "967.9" "1094.7" "1214.5" "1200.2" "1155.3" "1085.8" "1238.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7405227159340641842" "False" "High" "IsMasterProtein" "P62195" "26S proteasome regulatory subunit 8 OS=Homo sapiens OX=9606 GN=PSMC5 PE=1 SV=1" "0.000" "False" "45.323" "35" "12" "26" "12" "406" "45.6" "7.55" "63.77" "12" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00004, Pf16450, Pf17862" "5705" "ENSG00000087191" "PSMC5" "A8K3Z3; A8K763; hsa:5705; O35051; O43208; P47210; P52915; P52916; P62195" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Alzheimer's disease" "Regulation of expression of SLITs and ROBOs; Downstream TCR signaling; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "65" "0" "0.957" "0.968" "0.966" "0.960" "1.002" "0.920" "0.951" "0.883" "0.602" "1886.1" "1804.7" "1825.9" "1822.2" "1811.1" "1889.0" "1735.6" "1793.8" "1665.4" "1134.9" "" "" "" "" "" "" "" "" "" "" "998.7" "1000.6" "1045.7" "839.2" "979.9" "1050.7" "1021.4" "979.1" "934.3" "1134.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7824521577804774203" "False" "High" "IsMasterProtein" "Q53GS9" "Ubiquitin carboxyl-terminal hydrolase 39 OS=Homo sapiens OX=9606 GN=USP39 PE=1 SV=2" "0.000" "False" "45.234" "20" "11" "15" "11" "565" "65.3" "8.91" "44.13" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00443, Pf02148" "10713" "ENSG00000168883" "USP39" "A8K086; B3KM40; B4DHT4; D6W5L4; G5E9H0; hsa:10713; Q53GS9; Q6NX47; Q96RK9; Q9BV89; Q9H381; Q9P050; Q9Y310" "" "mRNA Splicing - Major Pathway" "1" "0" "1.087" "1.005" "1.060" "1.079" "1.099" "1.066" "1.146" "1.070" "0.494" "1645.6" "1788.9" "1653.3" "1743.7" "1776.3" "1808.6" "1754.3" "1885.1" "1761.1" "813.5" "" "" "" "" "" "" "" "" "" "" "871.3" "991.8" "946.8" "803.0" "961.1" "1006.0" "1032.5" "1029.0" "987.9" "813.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4848605729142375391" "False" "High" "IsMasterProtein" "P00813" "Adenosine deaminase OS=Homo sapiens OX=9606 GN=ADA PE=1 SV=3" "0.000" "False" "45.221" "28" "11" "20" "11" "363" "40.7" "5.95" "51.15" "11" "cell adhesion;cell cycle OR cell proliferation;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00962" "100" "ENSG00000196839" "ADA" "hsa:100; P00813; Q53F92; Q6LA59" "" "Ribavirin ADME; Purine salvage; Defective ADA disrupts (deoxy)adenosine deamination" "3" "0" "1.009" "1.040" "1.015" "1.032" "1.063" "0.979" "1.032" "1.094" "0.538" "1680.9" "1695.5" "1748.2" "1705.8" "1734.7" "1787.0" "1646.1" "1734.1" "1838.7" "905.0" "" "" "" "" "" "" "" "" "" "" "890.0" "940.0" "1001.2" "785.6" "938.5" "994.0" "968.8" "946.6" "1031.5" "905.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-45443448741042807" "False" "High" "IsMasterProtein" "P24928" "DNA-directed RNA polymerase II subunit RPB1 OS=Homo sapiens OX=9606 GN=POLR2A PE=1 SV=2" "0.000" "False" "45.187" "7" "14" "14" "14" "1970" "217.0" "7.37" "33.96" "14" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00623, Pf04983, Pf04990, Pf04992, Pf04997, Pf04998, Pf05000, Pf05001" "5430" "" "POLR2A" "A6NN93; B9EH88; hsa:5430; P24928; Q6NX41" "Pyrimidine metabolism; Eukaryotic transcription initiation; mRNA processing" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "44" "0" "0.972" "1.027" "1.031" "1.013" "1.003" "0.957" "0.804" "1.060" "2.163" "958.6" "932.0" "984.2" "988.7" "970.9" "961.0" "917.7" "770.6" "1016.3" "2073.8" "" "" "" "" "" "" "" "" "" "" "507.6" "516.7" "563.7" "455.3" "525.3" "534.6" "540.1" "420.6" "570.1" "2073.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1880293335037512275" "False" "High" "IsMasterProtein" "E9PAV3" "Nascent polypeptide-associated complex subunit alpha, muscle-specific form OS=Homo sapiens OX=9606 GN=NACA PE=1 SV=1" "0.000" "False" "45.164" "2" "4" "22" "4" "2078" "205.3" "9.58" "55.24" "4" "other biological processes" "translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01849, Pf19026" "" "ENSG00000196531" "NACA" "E9PAV3" "" "" "0" "0" "1.015" "1.051" "1.016" "1.019" "0.956" "0.964" "1.043" "0.954" "0.506" "1372.6" "1392.9" "1442.5" "1394.9" "1398.1" "1312.6" "1323.5" "1431.5" "1309.4" "694.2" "" "" "" "" "" "" "" "" "" "" "726.8" "772.3" "826.1" "642.4" "756.4" "730.1" "778.9" "781.4" "734.6" "694.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3010766793389346536" "False" "High" "IsMasterProtein" "P0DP25" "Calmodulin-3 OS=Homo sapiens OX=9606 GN=CALM3 PE=1 SV=1" "0.000" "False" "45.070" "43" "6" "45" "6" "149" "16.8" "4.22" "136.95" "6" "cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf13499" "801; 805; 808" "ENSG00000160014" "CALM3" "hsa:801; hsa:805; hsa:808; P02593; P0DP25; P62158; P70667; P99014; Q13942; Q53S29; Q61379; Q61380; Q96HK3" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Myometrial relaxation and contraction pathways; G protein signaling pathways; Ras signaling; Melanoma; Endochondral ossification; Endochondral ossification with skeletal dysplasias; CAMKK2 pathway; Glycogen synthesis and degradation; Neuroinflammation and glutamatergic signaling; Alzheimer's disease; G13 signaling pathway; Calcium regulation in cardiac cells" "" "17" "0" "0.940" "1.003" "1.001" "1.003" "0.898" "0.945" "0.938" "0.868" "0.587" "4713.0" "4431.3" "4727.4" "4717.0" "4726.6" "4230.3" "4455.1" "4419.4" "4090.0" "2765.0" "" "" "" "" "" "" "" "" "" "" "2495.5" "2456.8" "2707.4" "2172.3" "2557.3" "2353.1" "2622.0" "2412.3" "2294.4" "2765.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "868363632382073498" "False" "High" "IsMasterProtein" "Q6UB35" "Monofunctional C1-tetrahydrofolate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD1L PE=1 SV=1" "0.000" "False" "45.049" "13" "13" "24" "12" "978" "105.7" "8.06" "63.81" "13" "other metabolic processes;developmental processes" "cytosol;mitochondrion" "other molecular function" "Pf00763, Pf01268, Pf02882" "25902" "ENSG00000120254" "MTHFD1L" "hsa:25902; Q2TBF3; Q6UB35; Q8WVW0; Q96HG8; Q9H789; Q9UFU8" "One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways" "Metabolism of folate and pterines" "3" "0" "1.025" "0.956" "0.867" "0.967" "0.948" "0.758" "0.753" "0.818" "0.624" "2602.5" "2667.3" "2489.3" "2255.5" "2517.6" "2466.3" "1972.6" "1958.5" "2129.8" "1624.4" "" "" "" "" "" "" "" "" "" "" "1378.0" "1478.8" "1425.6" "1038.7" "1362.1" "1371.8" "1161.0" "1069.0" "1194.8" "1624.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7902692244369353681" "False" "High" "IsMasterProtein" "Q9Y6G9" "Cytoplasmic dynein 1 light intermediate chain 1 OS=Homo sapiens OX=9606 GN=DYNC1LI1 PE=1 SV=3" "0.000" "False" "45.041" "21" "10" "13" "10" "523" "56.5" "6.42" "35.91" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05783" "51143" "ENSG00000144635" "DYNC1LI1" "A2RRG7; hsa:51143; Q53HC8; Q53HK7; Q9Y6G9" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; MHC class II antigen presentation; HCMV Early Events; Neutrophil degranulation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy" "16" "0" "1.074" "0.949" "0.970" "1.013" "1.028" "0.858" "0.863" "0.878" "0.972" "684.4" "734.7" "649.6" "664.1" "693.5" "703.7" "587.0" "590.9" "601.0" "664.9" "" "" "" "" "" "" "" "" "" "" "362.4" "407.3" "372.0" "305.8" "375.2" "391.4" "345.5" "322.5" "337.2" "664.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1764632123327779223" "False" "High" "IsMasterProtein" "P46060" "Ran GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RANGAP1 PE=1 SV=1" "0.000" "False" "44.931" "12" "6" "10" "6" "587" "63.5" "4.68" "33.73" "6" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf07834, Pf13516" "5905" "ENSG00000100401" "RANGAP1" "hsa:5905; P46060; Q96JJ2" "22q11.2 copy number variation syndrome; IL-18 signaling pathway" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Rev-mediated nuclear export of HIV RNA; SUMOylation of DNA replication proteins; Postmitotic nuclear pore complex (NPC) reformation; SUMOylation of nuclear envelope proteins" "12" "0" "1.017" "1.006" "1.127" "1.134" "1.164" "1.336" "0.987" "1.225" "3.788" "588.2" "598.4" "591.5" "663.1" "666.9" "684.6" "785.8" "580.3" "720.7" "2228.2" "" "" "" "" "" "" "" "" "" "" "311.4" "331.8" "338.8" "305.4" "360.8" "380.8" "462.4" "316.7" "404.3" "2228.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1365252663665012706" "False" "High" "IsMasterProtein" "P49589" "Cysteine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=CARS1 PE=1 SV=3" "0.000" "False" "44.914" "16" "12" "21" "12" "748" "85.4" "6.76" "59.04" "12" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01406" "833" "ENSG00000110619; ENSG00000278191" "CARS1" "hsa:833; P49589; Q53XI8; Q5HYE4; Q9HD24; Q9HD25" "" "Signaling by ALK fusions and activated point mutants; Cytosolic tRNA aminoacylation" "2" "0" "1.008" "1.032" "1.003" "1.054" "0.995" "0.923" "0.894" "0.911" "0.710" "1177.3" "1186.9" "1214.4" "1180.4" "1241.3" "1171.0" "1086.5" "1052.4" "1072.6" "836.4" "" "" "" "" "" "" "" "" "" "" "623.4" "658.1" "695.5" "543.6" "671.6" "651.4" "639.5" "574.5" "601.7" "836.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7238306351176714360" "False" "High" "IsMasterProtein" "Q14974" "Importin subunit beta-1 OS=Homo sapiens OX=9606 GN=KPNB1 PE=1 SV=2" "0.000" "False" "44.891" "15" "12" "19" "12" "876" "97.1" "4.78" "43.63" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00514, Pf03810" "3837" "ENSG00000108424" "KPNB1" "B7ZAV6; D3DTT3; hsa:3837; Q14637; Q14974; Q53XN2; Q96J27" "Sterol regulatory element-binding proteins (SREBP) signaling; 22q11.2 copy number variation syndrome" "Neutrophil degranulation; Assembly of the ORC complex at the origin of replication; Apoptosis induced DNA fragmentation; Interferon alpha/beta signaling; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Nuclear import of Rev protein; Regulation of cholesterol biosynthesis by SREBP (SREBF); SARS-CoV-1 activates/modulates innate immune responses; Initiation of Nuclear Envelope (NE) Reformation; Postmitotic nuclear pore complex (NPC) reformation; Inhibition of nitric oxide production" "15" "0" "1.016" "0.895" "1.150" "1.022" "0.983" "1.196" "0.911" "1.117" "2.861" "960.0" "975.3" "858.7" "1104.0" "980.7" "943.9" "1148.5" "874.4" "1072.0" "2746.8" "" "" "" "" "" "" "" "" "" "" "508.3" "540.7" "491.8" "508.4" "530.6" "525.0" "675.9" "477.3" "601.4" "2746.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4008936127769007747" "False" "High" "IsMasterProtein" "O43314" "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 OS=Homo sapiens OX=9606 GN=PPIP5K2 PE=1 SV=3" "0.000" "False" "44.868" "9" "11" "13" "7" "1243" "140.3" "8.22" "40.12" "11" "other metabolic processes;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf00328, Pf18086" "23262" "ENSG00000145725" "PPIP5K2" "A1NI53; A6NGS8; hsa:23262; O43314; Q8TB50" "" "Synthesis of pyrophosphates in the cytosol" "1" "3" "1.042" "1.047" "0.936" "1.053" "1.013" "0.851" "0.848" "0.835" "0.723" "1628.3" "1696.0" "1704.1" "1523.9" "1714.5" "1649.0" "1385.4" "1380.1" "1359.1" "1177.6" "" "" "" "" "" "" "" "" "" "" "862.2" "940.3" "975.9" "701.8" "927.6" "917.3" "815.3" "753.3" "762.4" "1177.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8364348392468163032" "False" "High" "IsMasterProtein" "P04040" "Catalase OS=Homo sapiens OX=9606 GN=CAT PE=1 SV=3" "0.000" "False" "44.772" "14" "8" "14" "8" "527" "59.7" "7.39" "45.94" "8" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00199, Pf06628" "847" "ENSG00000121691" "CAT" "A8K6C0; B2RCZ9; D3DR07; hsa:847; P04040; Q2M1U4; Q4VXX5; Q9BWT9; Q9UC85" "Selenium micronutrient network; Folate metabolism; Amyotrophic lateral sclerosis (ALS); Oxidative stress response; Tryptophan metabolism; Male infertility; Arsenic metabolism and reactive oxygen species generation; DNA damage response (only ATM dependent)" "Neutrophil degranulation; Peroxisomal protein import; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Detoxification of Reactive Oxygen Species" "12" "0" "0.977" "0.987" "0.947" "1.041" "1.000" "1.020" "1.006" "0.934" "0.590" "945.0" "922.9" "933.1" "894.6" "983.5" "944.8" "963.9" "950.3" "882.4" "558.0" "" "" "" "" "" "" "" "" "" "" "500.4" "511.7" "534.4" "412.0" "532.1" "525.5" "567.3" "518.7" "495.0" "558.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2986049448252169894" "False" "High" "IsMasterProtein" "Q8N3U4" "Cohesin subunit SA-2 OS=Homo sapiens OX=9606 GN=STAG2 PE=1 SV=3" "0.000" "False" "44.660" "11" "11" "13" "10" "1231" "141.2" "5.43" "37.12" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08514, Pf21581" "10735" "ENSG00000101972" "STAG2" "B1AMT5; D3DTF5; hsa:10735; O00540; Q5JTI6; Q68DE9; Q8N3U4; Q9H1N8" "Cell cycle; Cohesin complex - Cornelia de Lange syndrome" "Resolution of Sister Chromatid Cohesion; Separation of Sister Chromatids; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "9" "1" "0.987" "0.957" "0.881" "0.911" "0.964" "0.857" "0.941" "0.916" "0.838" "2093.6" "2065.6" "2002.9" "1844.3" "1907.7" "2018.2" "1794.5" "1969.6" "1917.2" "1754.5" "" "" "" "" "" "" "" "" "" "" "1108.6" "1145.2" "1147.1" "849.3" "1032.1" "1122.6" "1056.1" "1075.1" "1075.5" "1754.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8737911317243548471" "False" "High" "IsMasterProtein" "Q15631" "Translin OS=Homo sapiens OX=9606 GN=TSN PE=1 SV=1" "0.000" "False" "44.567" "27" "8" "19" "8" "228" "26.2" "6.44" "57.59" "8" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01997" "7247" "ENSG00000211460" "TSN" "B7Z3X8; hsa:7247; Q15631; Q5U0K7" "" "Small interfering RNA (siRNA) biogenesis" "1" "0" "1.003" "0.944" "0.980" "0.989" "1.036" "1.004" "1.028" "0.983" "0.643" "1616.2" "1620.8" "1526.5" "1584.0" "1598.1" "1674.7" "1621.9" "1660.8" "1589.0" "1039.5" "" "" "" "" "" "" "" "" "" "" "855.8" "898.6" "874.2" "729.5" "864.6" "931.6" "954.6" "906.6" "891.4" "1039.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4594033010686828793" "False" "High" "IsMasterProtein" "P48637" "Glutathione synthetase OS=Homo sapiens OX=9606 GN=GSS PE=1 SV=1" "0.000" "False" "44.472" "25" "12" "16" "12" "474" "52.4" "5.92" "47.06" "12" "other metabolic processes;stress response;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf03199, Pf03917" "2937" "ENSG00000100983" "GSS" "B2R697; B6F210; E1P5P9; hsa:2937; P48637; Q4TTD9" "Glutathione metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Amino acid metabolism; One-carbon metabolism and related pathways; Ferroptosis; Metapathway biotransformation Phase I and II" "Glutathione synthesis and recycling; Defective GSS causes GSS deficiency" "8" "0" "0.980" "0.974" "0.994" "1.046" "1.030" "1.037" "1.034" "0.995" "0.510" "1940.0" "1900.5" "1889.4" "1928.6" "2029.2" "1997.9" "2011.0" "2005.9" "1930.4" "990.2" "" "" "" "" "" "" "" "" "" "" "1027.2" "1053.7" "1082.0" "888.2" "1097.9" "1111.3" "1183.6" "1094.9" "1082.9" "990.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3211102690049465357" "False" "High" "IsMasterProtein" "P11310" "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADM PE=1 SV=1" "0.000" "False" "44.411" "23" "10" "16" "10" "421" "46.6" "8.37" "52.09" "10" "other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00441, Pf02770, Pf02771" "34" "ENSG00000117054" "ACADM" "hsa:34; P11310; Q5T4U4; Q9NYF1" "Fatty acid beta-oxidation; PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; Amino acid metabolism; PPAR signaling pathway; Mitochondrial fatty acid oxidation disorders; Female steroid hormones in cardiomyocyte energy metabolism; Sudden infant death syndrome (SIDS) susceptibility pathways" "PPARA activates gene expression; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA" "13" "0" "0.983" "1.024" "0.916" "0.944" "0.982" "0.941" "0.923" "0.857" "0.511" "1852.5" "1821.9" "1897.3" "1696.1" "1748.0" "1819.0" "1742.4" "1709.4" "1588.4" "945.8" "" "" "" "" "" "" "" "" "" "" "980.9" "1010.1" "1086.6" "781.1" "945.7" "1011.8" "1025.4" "933.1" "891.0" "945.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6888826320597161834" "False" "High" "IsMasterProtein" "Q16630" "Cleavage and polyadenylation specificity factor subunit 6 OS=Homo sapiens OX=9606 GN=CPSF6 PE=1 SV=2" "0.000" "False" "44.347" "21" "10" "22" "10" "551" "59.2" "7.15" "50.60" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00076" "11052" "ENSG00000111605" "CPSF6" "A8K7K9; hsa:11052; Q16630; Q53ES1; Q9BSJ7; Q9BW18" "" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "2" "0" "1.179" "0.897" "0.917" "1.059" "1.007" "0.974" "0.891" "1.038" "0.714" "749.0" "882.9" "671.9" "687.0" "793.2" "754.3" "729.6" "667.3" "777.5" "534.8" "" "" "" "" "" "" "" "" "" "" "396.6" "489.5" "384.8" "316.4" "429.1" "419.6" "429.4" "364.3" "436.1" "534.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6739542972395274555" "False" "High" "IsMasterProtein" "Q9P265" "Disco-interacting protein 2 homolog B OS=Homo sapiens OX=9606 GN=DIP2B PE=1 SV=3" "0.000" "False" "44.208" "8" "11" "13" "11" "1576" "171.4" "8.09" "37.51" "11" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity" "Pf00501, Pf06464" "57609" "ENSG00000066084" "DIP2B" "hsa:57609; Q6B011; Q8N1L5; Q8NB38; Q9P265" "" "" "0" "0" "0.989" "0.947" "0.978" "0.989" "0.979" "0.877" "0.879" "0.873" "0.596" "816.6" "807.9" "773.7" "798.7" "807.5" "799.8" "716.2" "717.7" "712.8" "486.7" "" "" "" "" "" "" "" "" "" "" "432.4" "447.9" "443.1" "367.8" "436.9" "444.9" "421.5" "391.8" "399.8" "486.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7273803465605434037" "False" "High" "IsMasterProtein" "P05455" "Lupus La protein OS=Homo sapiens OX=9606 GN=SSB PE=1 SV=2" "0.000" "False" "44.166" "28" "12" "19" "12" "408" "46.8" "7.12" "51.79" "12" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf05383, Pf08777" "6741" "ENSG00000138385" "SSB" "hsa:6741; P05455; Q15367; Q53XJ4" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination" "2" "0" "0.999" "1.047" "1.018" "0.942" "0.986" "0.861" "0.896" "0.916" "1.270" "2318.7" "2315.8" "2427.1" "2360.1" "2184.5" "2285.6" "1995.8" "2078.2" "2123.9" "2944.2" "" "" "" "" "" "" "" "" "" "" "1227.8" "1283.9" "1390.0" "1086.9" "1181.9" "1271.3" "1174.6" "1134.4" "1191.4" "2944.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-478504765432675351" "False" "High" "IsMasterProtein" "P30520" "Adenylosuccinate synthetase isozyme 2 OS=Homo sapiens OX=9606 GN=ADSS2 PE=1 SV=3" "0.000" "False" "44.138" "18" "8" "18" "8" "456" "50.1" "6.55" "54.38" "8" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00709" "159" "ENSG00000035687" "ADSS2" "B1AQM5; hsa:159; P30520; Q96EG7" "" "Purine ribonucleoside monophosphate biosynthesis" "1" "0" "0.927" "0.961" "0.881" "0.944" "0.969" "0.910" "0.981" "0.936" "0.584" "2128.0" "1971.9" "2045.7" "1873.8" "2009.6" "2062.6" "1935.4" "2088.4" "1991.1" "1242.6" "" "" "" "" "" "" "" "" "" "" "1126.8" "1093.3" "1171.6" "863.0" "1087.3" "1147.3" "1139.0" "1139.9" "1117.0" "1242.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1108045160068185156" "False" "High" "IsMasterProtein" "P20073" "Annexin A7 OS=Homo sapiens OX=9606 GN=ANXA7 PE=1 SV=3" "0.000" "False" "44.137" "25" "11" "15" "11" "488" "52.7" "5.68" "39.82" "11" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00191" "310" "ENSG00000138279" "ANXA7" "hsa:310; P20073; Q5F2H3; Q5T0M6; Q5T0M7" "" "" "0" "0" "1.053" "1.046" "1.065" "1.101" "1.095" "1.071" "1.031" "1.018" "1.475" "1056.0" "1111.8" "1104.3" "1124.9" "1163.0" "1156.9" "1131.3" "1088.8" "1075.3" "1557.9" "" "" "" "" "" "" "" "" "" "" "559.2" "616.4" "632.4" "518.0" "629.2" "643.5" "665.8" "594.3" "603.2" "1557.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8621700409293052339" "False" "High" "IsMasterProtein" "P23368" "NAD-dependent malic enzyme, mitochondrial OS=Homo sapiens OX=9606 GN=ME2 PE=1 SV=1" "0.000" "False" "44.090" "13" "7" "12" "6" "584" "65.4" "7.61" "34.39" "7" "other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00390, Pf03949" "4200" "ENSG00000082212" "ME2" "B2R8J2; hsa:4200; P23368; Q9BWL6; Q9BYG1; Q9H4B2" "TCA cycle in senescence" "Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "3" "1" "1.044" "1.016" "1.121" "1.103" "1.114" "1.253" "1.328" "1.184" "1.167" "961.7" "1004.1" "976.7" "1077.9" "1060.5" "1071.3" "1204.8" "1276.8" "1138.9" "1121.9" "" "" "" "" "" "" "" "" "" "" "509.2" "556.7" "559.4" "496.4" "573.8" "595.9" "709.1" "696.9" "638.9" "1121.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "523405854747225660" "False" "High" "IsMasterProtein" "Q16222" "UDP-N-acetylhexosamine pyrophosphorylase OS=Homo sapiens OX=9606 GN=UAP1 PE=1 SV=3" "0.000" "False" "44.072" "20" "10" "20" "8" "522" "58.7" "6.33" "56.14" "10" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf01704" "6675" "ENSG00000117143" "UAP1" "B2R6R8; hsa:6675; Q16222; Q5VTA9; Q5VTB0; Q5VTB1; Q96GM2" "" "Synthesis of UDP-N-acetyl-glucosamine" "1" "2" "0.977" "0.995" "1.019" "0.981" "1.071" "1.004" "1.033" "1.048" "0.599" "1963.4" "1917.7" "1952.7" "2001.4" "1926.0" "2103.3" "1971.4" "2029.0" "2057.0" "1176.0" "" "" "" "" "" "" "" "" "" "" "1039.6" "1063.2" "1118.3" "921.7" "1042.1" "1170.0" "1160.2" "1107.5" "1154.0" "1176.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6256395688163039861" "False" "High" "IsMasterProtein" "O75643" "U5 small nuclear ribonucleoprotein 200 kDa helicase OS=Homo sapiens OX=9606 GN=SNRNP200 PE=1 SV=2" "0.000" "False" "43.999" "5" "10" "14" "10" "2136" "244.4" "6.06" "38.03" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf02889, Pf18149, Pf21188" "23020" "ENSG00000144028" "SNRNP200" "hsa:23020; O75643; O94884; Q6NZY0; Q6PX59; Q8NBE6; Q96IF2; Q9H7S0" "2q11.2 copy number variation syndrome" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "1.020" "1.032" "1.087" "0.991" "1.013" "1.004" "0.894" "1.028" "1.513" "993.4" "1012.8" "1025.3" "1079.6" "984.1" "1006.3" "997.4" "888.0" "1021.4" "1503.0" "" "" "" "" "" "" "" "" "" "" "526.0" "561.5" "587.2" "497.2" "532.5" "559.7" "587.0" "484.7" "573.0" "1503.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2123612860387903516" "False" "High" "IsMasterProtein" "P08243" "Asparagine synthetase [glutamine-hydrolyzing] OS=Homo sapiens OX=9606 GN=ASNS PE=1 SV=4" "0.000" "False" "43.789" "19" "11" "18" "11" "561" "64.3" "6.86" "47.72" "11" "other metabolic processes;stress response;other biological processes" "cytosol" "other molecular function" "Pf00733, Pf13537" "440" "ENSG00000070669" "ASNS" "A4D1I8; B4DXZ1; B7ZAA9; D6W5R3; E9PCI3; E9PCX6; hsa:440; P08184; P08243; Q15666; Q549T9; Q96HD0" "Photodynamic therapy-induced unfolded protein response; Amino acid metabolism" "Aspartate and asparagine metabolism; Response of EIF2AK1 (HRI) to heme deficiency; ATF4 activates genes in response to endoplasmic reticulum stress; Response of EIF2AK4 (GCN2) to amino acid deficiency" "6" "0" "1.023" "1.002" "0.974" "1.041" "1.035" "0.907" "0.917" "0.941" "0.586" "1340.3" "1371.0" "1342.7" "1306.1" "1395.9" "1387.0" "1215.5" "1229.3" "1261.0" "785.9" "" "" "" "" "" "" "" "" "" "" "709.7" "760.1" "769.0" "601.5" "755.2" "771.5" "715.4" "671.0" "707.4" "785.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7630142415015692295" "False" "High" "IsMasterProtein" "P14314" "Glucosidase 2 subunit beta OS=Homo sapiens OX=9606 GN=PRKCSH PE=1 SV=2" "0.000" "False" "43.787" "20" "9" "22" "9" "528" "59.4" "4.41" "58.78" "9" "protein metabolism;other metabolic processes;developmental processes;signal transduction" "ER/Golgi;other cell component" "other molecular function" "Pf12999, Pf13015, Pf13202" "5589" "ENSG00000130175" "PRKCSH" "A8K318; hsa:5589; P14314; Q96BU9; Q96D06; Q9P0W9" "" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Advanced glycosylation endproduct receptor signaling; Maturation of spike protein; Calnexin/calreticulin cycle; Maturation of spike protein" "7" "0" "1.052" "1.017" "0.993" "1.002" "0.952" "1.021" "1.067" "0.999" "0.713" "1554.4" "1634.6" "1580.2" "1543.4" "1557.7" "1479.7" "1586.4" "1659.1" "1552.8" "1107.8" "" "" "" "" "" "" "" "" "" "" "823.1" "906.2" "905.0" "710.8" "842.8" "823.1" "933.6" "905.7" "871.1" "1107.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2447510198658431817" "False" "High" "IsMasterProtein" "Q9H910" "Jupiter microtubule associated homolog 2 OS=Homo sapiens OX=9606 GN=JPT2 PE=1 SV=1" "0.000" "False" "43.697" "47" "8" "14" "8" "190" "20.1" "9.26" "39.30" "8" "transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf17054" "90861" "ENSG00000206053" "JPT2" "B1AJY2; B4DLH4; hsa:90861; Q6EIC7; Q9H910" "" "" "0" "0" "0.919" "0.963" "0.941" "0.893" "0.903" "0.910" "0.949" "0.860" "0.615" "749.8" "689.3" "722.4" "705.3" "669.6" "676.9" "682.5" "711.4" "644.6" "461.2" "" "" "" "" "" "" "" "" "" "" "397.0" "382.2" "413.7" "324.8" "362.3" "376.5" "401.7" "388.3" "361.6" "461.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8112712839841425381" "False" "High" "IsMasterProtein" "Q8TAQ2" "SWI/SNF complex subunit SMARCC2 OS=Homo sapiens OX=9606 GN=SMARCC2 PE=1 SV=1" "0.000" "False" "43.681" "10" "11" "18" "8" "1214" "132.8" "5.69" "49.76" "11" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf04433, Pf16495, Pf16496, Pf16498" "6601" "ENSG00000139613" "SMARCC2" "F8VTJ5; hsa:6601; Q59GV3; Q8TAQ2; Q92923; Q96E12; Q96GY4" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome; 10q11.21q11.23 copy number variation syndrome" "RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "7" "3" "1.092" "1.074" "1.150" "1.077" "1.111" "1.234" "0.953" "1.193" "3.972" "926.1" "1010.9" "994.9" "1064.5" "997.2" "1029.2" "1142.3" "882.2" "1105.0" "3678.6" "" "" "" "" "" "" "" "" "" "" "490.4" "560.5" "569.8" "490.3" "539.5" "572.5" "672.3" "481.6" "619.9" "3678.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-108024960006830899" "False" "High" "IsMasterProtein" "Q99873" "Protein arginine N-methyltransferase 1 OS=Homo sapiens OX=9606 GN=PRMT1 PE=1 SV=3" "0.000" "False" "43.681" "20" "8" "23" "8" "371" "42.4" "5.35" "42.27" "8" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13649" "3276" "ENSG00000126457" "PRMT1" "A0A087X1W2; B4E3C3; G5E9B6; H7C2I1; hsa:3276; Q15529; Q2VP93; Q6LEU5; Q8WUW5; Q99872; Q99873; Q99874; Q9NZ04; Q9NZ05; Q9NZ06" "Energy metabolism; mRNA processing; Nitric oxide metabolism in cystic fibrosis; 16p11.2 distal deletion syndrome; Interferon type I signaling pathways" "Estrogen-dependent gene expression; Extra-nuclear estrogen signaling; RMTs methylate histone arginines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Maturation of nucleoprotein" "11" "0" "0.963" "0.974" "0.982" "0.986" "0.934" "1.002" "0.962" "0.894" "0.592" "978.9" "943.1" "952.9" "961.0" "965.4" "914.6" "980.8" "941.2" "875.2" "579.8" "" "" "" "" "" "" "" "" "" "" "518.3" "522.9" "545.7" "442.6" "522.3" "508.8" "577.2" "513.8" "490.9" "579.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2000149413272750326" "False" "High" "IsMasterProtein" "Q15907" "Ras-related protein Rab-11B OS=Homo sapiens OX=9606 GN=RAB11B PE=1 SV=4" "0.000" "False" "43.677" "37" "9" "19" "9" "218" "24.5" "5.94" "49.71" "9" "cell-cell signaling;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "9230" "ENSG00000185236" "RAB11B" "A5YM50; B2R7I4; B4DMK0; D6W671; hsa:9230; Q15907; Q2YDT2; Q5U0I1; Q6FHR0; Q6FI42; Q8NI07" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Intracellular trafficking proteins involved in CMT neuropathy; Vasopressin-regulated water reabsorption" "RAB geranylgeranylation; TBC/RABGAPs" "5" "0" "1.001" "1.001" "0.892" "0.989" "1.029" "0.953" "1.029" "0.960" "0.588" "1358.5" "1360.1" "1360.2" "1212.4" "1343.8" "1398.5" "1294.0" "1398.0" "1303.8" "799.3" "" "" "" "" "" "" "" "" "" "" "719.3" "754.1" "779.0" "558.4" "727.1" "777.9" "761.6" "763.1" "731.4" "799.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5866289401045489846" "False" "High" "IsMasterProtein" "Q92616" "Stalled ribosome sensor GCN1 OS=Homo sapiens OX=9606 GN=GCN1 PE=1 SV=7" "0.000" "False" "43.659" "6" "17" "19" "17" "2671" "292.5" "7.43" "40.15" "17" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;other cell component" "enzyme regulator activity;translation activity;nucleic acid binding activity;other molecular function" "" "10985" "ENSG00000089154" "GCN1" "A8KAY1; hsa:10985; O95001; O95651; Q6P2S3; Q86X65; Q8N5I5; Q8WU80; Q92616; Q99736; Q9UE60" "" "Response of EIF2AK4 (GCN2) to amino acid deficiency" "1" "0" "1.074" "1.087" "1.214" "1.047" "1.087" "1.030" "0.617" "1.113" "6.883" "491.0" "527.3" "533.6" "596.2" "514.0" "533.9" "505.6" "303.0" "546.5" "3379.4" "" "" "" "" "" "" "" "" "" "" "260.0" "292.3" "305.6" "274.6" "278.1" "297.0" "297.6" "165.4" "306.6" "3379.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3504989653461023373" "False" "High" "IsMasterProtein" "P51570" "Galactokinase OS=Homo sapiens OX=9606 GN=GALK1 PE=1 SV=1" "0.000" "False" "43.591" "22" "8" "18" "8" "392" "42.2" "6.46" "55.51" "8" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00288, Pf08544, Pf10509" "2584" "ENSG00000108479" "GALK1" "B2RC07; B4E1G6; hsa:2584; P51570" "Disorders of galactose metabolism" "Galactose catabolism; Defective GALK1 causes GALCT2" "3" "0" "0.956" "0.986" "1.080" "1.066" "0.994" "0.876" "0.877" "0.883" "0.615" "977.8" "935.2" "964.3" "1056.2" "1042.3" "972.2" "857.0" "857.1" "863.4" "601.6" "" "" "" "" "" "" "" "" "" "" "517.7" "518.5" "552.3" "486.4" "563.9" "540.8" "504.4" "467.8" "484.3" "601.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8919089648667332764" "False" "High" "IsMasterProtein" "Q6NZY4" "Zinc finger CCHC domain-containing protein 8 OS=Homo sapiens OX=9606 GN=ZCCHC8 PE=1 SV=2" "0.000" "False" "43.416" "15" "8" "9" "8" "707" "78.5" "4.87" "29.68" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00098, Pf04046" "55596" "ENSG00000033030" "ZCCHC8" "hsa:55596; Q6NZY4; Q7L2P6; Q8N2K5; Q96SK7; Q9NSS2; Q9NSS3" "" "" "0" "0" "1.047" "0.974" "0.936" "1.059" "0.972" "0.973" "0.940" "0.978" "0.769" "676.5" "708.2" "658.6" "633.1" "716.4" "657.4" "658.0" "635.7" "661.7" "520.1" "" "" "" "" "" "" "" "" "" "" "358.2" "392.7" "377.2" "291.6" "387.6" "365.7" "387.3" "347.0" "371.2" "520.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8809117759024256443" "False" "High" "IsMasterProtein" "P29692" "Elongation factor 1-delta OS=Homo sapiens OX=9606 GN=EEF1D PE=1 SV=5" "0.000" "False" "43.390" "33" "7" "12" "6" "281" "31.1" "5.01" "39.20" "7" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00736, Pf10587" "1936" "ENSG00000104529; ENSG00000273594" "EEF1D" "B4DDU4; D3DWK3; E9PBQ9; hsa:1936; P29692; Q4VBZ6; Q969J1; Q96I38" "Translation factors" "Eukaryotic Translation Elongation" "2" "0" "1.003" "0.997" "1.016" "1.051" "1.111" "0.984" "0.874" "1.001" "2.953" "970.1" "973.3" "967.4" "986.0" "1019.3" "1077.7" "954.8" "848.3" "971.1" "2864.9" "" "" "" "" "" "" "" "" "" "" "513.7" "539.6" "554.0" "454.1" "551.5" "599.4" "562.0" "463.1" "544.8" "2864.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8676466481375871245" "False" "High" "IsMasterProtein" "P08133" "Annexin A6 OS=Homo sapiens OX=9606 GN=ANXA6 PE=1 SV=3" "0.000" "False" "43.265" "16" "11" "12" "11" "673" "75.8" "5.60" "35.77" "11" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component" "transporter activity;cytoskeletal activity;other molecular function" "Pf00191" "309" "ENSG00000197043" "ANXA6" "B7Z8A7; D3DQH4; E9PGK1; hsa:309; P08133; Q6ZT79" "Calcium regulation in cardiac cells; Prostaglandin synthesis and regulation" "Smooth Muscle Contraction" "3" "0" "1.077" "1.023" "0.913" "0.976" "1.048" "1.008" "0.899" "0.997" "2.090" "1318.7" "1420.1" "1348.9" "1204.2" "1287.5" "1381.3" "1329.8" "1185.9" "1315.4" "2755.5" "" "" "" "" "" "" "" "" "" "" "698.2" "787.4" "772.5" "554.6" "696.6" "768.4" "782.6" "647.4" "737.9" "2755.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2064458318068970757" "False" "High" "IsMasterProtein" "Q96QK1" "Vacuolar protein sorting-associated protein 35 OS=Homo sapiens OX=9606 GN=VPS35 PE=1 SV=2" "0.000" "False" "43.221" "12" "9" "24" "9" "796" "91.6" "5.49" "65.47" "9" "cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding" "Pf03635" "55737" "ENSG00000069329" "VPS35" "hsa:55737; Q561W2; Q96QK1; Q9H016; Q9H096; Q9H4P3; Q9H8J0; Q9NRS7; Q9NVG2; Q9NX80; Q9NZK2" "" "WNT ligand biogenesis and trafficking" "1" "0" "1.036" "0.955" "1.091" "1.030" "0.994" "1.062" "1.019" "1.004" "0.837" "903.7" "936.2" "863.0" "986.2" "931.2" "898.1" "959.6" "921.0" "907.0" "756.7" "" "" "" "" "" "" "" "" "" "" "478.5" "519.1" "494.2" "454.2" "503.8" "499.6" "564.7" "502.7" "508.8" "756.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5198752139468277763" "False" "High" "IsMasterProtein" "Q96PK6" "RNA-binding protein 14 OS=Homo sapiens OX=9606 GN=RBM14 PE=1 SV=2" "0.000" "False" "43.169" "14" "10" "12" "10" "669" "69.4" "9.67" "34.71" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00076" "100526737; 10432" "ENSG00000239306" "RBM14" "B0LM41; B3KMN4; D6RGD8; hsa:100526737; hsa:10432; O75932; Q2PYN1; Q53GV1; Q68DQ9; Q96PK5; Q96PK6" "Ciliary landscape" "RUNX2 regulates bone development" "2" "0" "0.952" "1.005" "1.012" "1.083" "1.011" "1.051" "0.728" "1.024" "5.018" "528.0" "502.9" "530.8" "534.4" "571.9" "533.9" "554.9" "384.6" "540.7" "2649.7" "" "" "" "" "" "" "" "" "" "" "279.6" "278.8" "304.0" "246.1" "309.4" "297.0" "326.6" "210.0" "303.3" "2649.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5926930809007955556" "False" "High" "IsMasterProtein" "Q92598" "Heat shock protein 105 kDa OS=Homo sapiens OX=9606 GN=HSPH1 PE=1 SV=1" "0.000" "False" "43.167" "11" "8" "14" "7" "858" "96.8" "5.39" "31.70" "8" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00012" "10808" "ENSG00000120694" "HSPH1" "B4DYH1; hsa:10808; O95739; Q5TBM6; Q5TBM7; Q5TBM8; Q92598; Q9UPC4" "" "Regulation of HSF1-mediated heat shock response; Scavenging by Class F Receptors" "2" "0" "1.062" "0.999" "1.161" "1.087" "0.962" "1.542" "1.433" "1.434" "2.915" "612.4" "650.3" "611.9" "710.8" "666.0" "589.2" "944.5" "877.8" "877.9" "1785.4" "" "" "" "" "" "" "" "" "" "" "324.3" "360.5" "350.4" "327.4" "360.3" "327.7" "555.8" "479.1" "492.5" "1785.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3101677286908017403" "False" "High" "IsMasterProtein" "Q9Y450" "HBS1-like protein OS=Homo sapiens OX=9606 GN=HBS1L PE=1 SV=1" "0.000" "False" "43.126" "18" "11" "11" "11" "684" "75.4" "6.61" "35.35" "11" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144, Pf08938" "10767" "ENSG00000112339" "HBS1L" "B7Z365; hsa:10767; Q4VX89; Q4VX90; Q5T7G3; Q8NDW9; Q9UPW3; Q9Y450" "" "mRNA decay by 3' to 5' exoribonuclease" "1" "0" "1.018" "0.989" "1.042" "0.971" "0.956" "0.933" "0.871" "0.880" "1.039" "1230.6" "1252.2" "1217.1" "1282.6" "1195.3" "1176.4" "1148.1" "1071.4" "1082.8" "1278.9" "" "" "" "" "" "" "" "" "" "" "651.6" "694.2" "697.0" "590.7" "646.7" "654.4" "675.7" "584.8" "607.4" "1278.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1669243048092869257" "False" "High" "IsMasterProtein" "Q8WU90" "Zinc finger CCCH domain-containing protein 15 OS=Homo sapiens OX=9606 GN=ZC3H15 PE=1 SV=1" "0.000" "False" "42.943" "23" "10" "19" "10" "426" "48.6" "5.31" "51.26" "10" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00642, Pf16543" "55854" "ENSG00000065548" "ZC3H15" "B4DMW2; D3DPG7; hsa:55854; Q5QTQ4; Q8WU90; Q8WZ06; Q9NUZ3; Q9NZ37; Q9P079" "VEGFA-VEGFR2 signaling" "Protein hydroxylation" "2" "0" "0.986" "0.994" "0.982" "0.985" "0.943" "0.935" "0.921" "0.936" "0.623" "2460.1" "2425.5" "2444.5" "2416.1" "2423.5" "2320.8" "2301.2" "2266.3" "2302.5" "1533.0" "" "" "" "" "" "" "" "" "" "" "1302.6" "1344.8" "1400.0" "1112.7" "1311.2" "1290.9" "1354.4" "1237.1" "1291.6" "1533.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6625268949045148761" "False" "High" "IsMasterProtein" "Q8N163" "Cell cycle and apoptosis regulator protein 2 OS=Homo sapiens OX=9606 GN=CCAR2 PE=1 SV=2" "0.000" "False" "42.894" "11" "9" "14" "9" "923" "102.8" "5.22" "37.73" "9" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf14443, Pf14444, Pf19256, Pf19257" "57805" "ENSG00000158941" "CCAR2" "A6NL03; B2RB79; D3DSR6; hsa:57805; Q6P0Q9; Q8N163; Q8N3G7; Q8N8M1; Q8TF34; Q9H9Q9; Q9HD12; Q9NT55" "TAR syndrome" "Regulation of HSF1-mediated heat shock response" "2" "0" "1.077" "1.048" "1.266" "1.141" "1.156" "1.647" "1.274" "1.545" "5.642" "533.0" "574.0" "558.5" "674.7" "608.3" "616.3" "877.9" "679.2" "823.7" "3007.5" "" "" "" "" "" "" "" "" "" "" "282.2" "318.3" "319.8" "310.7" "329.1" "342.8" "516.7" "370.8" "462.0" "3007.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2859585786570282431" "False" "High" "IsMasterProtein" "P08237" "ATP-dependent 6-phosphofructokinase, muscle type OS=Homo sapiens OX=9606 GN=PFKM PE=1 SV=2" "0.000" "False" "42.835" "15" "11" "15" "8" "780" "85.1" "7.99" "45.84" "11" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "kinase activity;other molecular function" "Pf00365" "5213" "ENSG00000152556" "PFKM" "hsa:5213; J3KNX3; P08237; Q16814; Q16815; Q6ZTT1" "Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Insulin signaling; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis" "6" "0" "1.023" "0.994" "1.013" "0.910" "0.921" "0.906" "1.018" "0.893" "0.539" "1217.1" "1244.9" "1209.9" "1233.3" "1107.1" "1121.2" "1102.4" "1239.4" "1087.3" "656.0" "" "" "" "" "" "" "" "" "" "" "644.4" "690.2" "692.9" "568.0" "599.0" "623.7" "648.8" "676.5" "610.0" "656.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4969785199518402327" "False" "High" "IsMasterProtein" "Q13098" "COP9 signalosome complex subunit 1 OS=Homo sapiens OX=9606 GN=GPS1 PE=1 SV=4" "0.000" "False" "42.782" "15" "8" "16" "8" "491" "55.5" "6.74" "48.61" "8" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01399, Pf10602, Pf21151" "2873" "ENSG00000169727" "GPS1" "hsa:2873; Q13098; Q8NA10; Q9BWL1" "" "Neddylation; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; RHOBTB1 GTPase cycle; DNA Damage Recognition in GG-NER" "5" "0" "1.010" "0.990" "1.027" "1.039" "1.042" "1.072" "1.061" "0.976" "0.682" "1838.4" "1856.9" "1819.6" "1887.8" "1909.6" "1915.6" "1970.2" "1950.4" "1793.8" "1253.3" "" "" "" "" "" "" "" "" "" "" "973.4" "1029.5" "1042.1" "869.4" "1033.2" "1065.5" "1159.5" "1064.7" "1006.3" "1253.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1978266596079071295" "False" "High" "IsMasterProtein" "Q01518" "Adenylyl cyclase-associated protein 1 OS=Homo sapiens OX=9606 GN=CAP1 PE=1 SV=5" "0.000" "False" "42.731" "25" "12" "30" "12" "475" "51.9" "8.06" "73.08" "12" "cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf01213, Pf08603" "10487" "ENSG00000131236" "CAP1" "hsa:10487; Q01518; Q53HR7; Q5T0S1; Q5T0S2; Q6I9U6" "Angiopoietin-like protein 8 regulatory pathway; Insulin signaling; Complement system in neuronal development and plasticity; Opioid receptor pathways" "Neutrophil degranulation; Platelet degranulation ; Role of ABL in ROBO-SLIT signaling" "7" "0" "0.933" "0.987" "0.881" "0.915" "0.947" "0.903" "0.950" "0.926" "0.568" "2633.8" "2456.8" "2598.3" "2321.2" "2409.9" "2494.1" "2379.4" "2502.3" "2439.3" "1496.3" "" "" "" "" "" "" "" "" "" "" "1394.6" "1362.1" "1488.0" "1069.0" "1303.8" "1387.3" "1400.4" "1365.9" "1368.4" "1496.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4007751392279359432" "False" "High" "IsMasterProtein" "Q562R1" "Beta-actin-like protein 2 OS=Homo sapiens OX=9606 GN=ACTBL2 PE=1 SV=2" "0.000" "False" "42.683" "15" "7" "100" "1" "376" "42.0" "5.59" "256.87" "7" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "345651" "ENSG00000169067" "ACTBL2" "B2RPJ1; hsa:345651; Q562R1; Q562R2; Q562S9; Q562X8" "" "" "0" "0" "1.086" "1.002" "1.210" "1.059" "1.168" "1.162" "1.092" "0.982" "0.704" "89.3" "97.0" "89.4" "108.0" "94.6" "104.3" "103.8" "97.5" "87.7" "62.8" "" "" "" "" "" "" "" "" "" "" "47.3" "53.8" "51.2" "49.8" "51.2" "58.0" "61.1" "53.2" "49.2" "62.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2946380844768102927" "False" "High" "IsMasterProtein" "Q96I24" "Far upstream element-binding protein 3 OS=Homo sapiens OX=9606 GN=FUBP3 PE=1 SV=2" "0.000" "False" "42.674" "19" "11" "19" "9" "572" "61.6" "8.38" "53.76" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf00013" "8939" "ENSG00000107164" "FUBP3" "A3KFK8; A3KFL0; hsa:8939; Q92946; Q96I24; Q9BVB6" "" "" "0" "0" "0.984" "0.960" "0.950" "1.016" "0.996" "1.079" "0.972" "1.074" "1.668" "1006.0" "989.6" "965.4" "955.5" "1021.6" "1001.9" "1085.9" "977.4" "1080.8" "1678.2" "" "" "" "" "" "" "" "" "" "" "532.7" "548.6" "552.9" "440.1" "552.7" "557.3" "639.1" "533.5" "606.3" "1678.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "193290723324093172" "False" "High" "IsMasterProtein" "P33316" "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=DUT PE=1 SV=4" "0.000" "False" "42.669" "42" "9" "15" "9" "252" "26.5" "9.36" "47.18" "9" "DNA metabolism;other metabolic processes;developmental processes;other biological processes" "mitochondrion;nucleus" "signal transduction activity or receptor binding;other molecular function" "Pf00692" "1854" "ENSG00000128951" "DUT" "A8K650; B4DPR5; hsa:1854; O14785; P33316; Q16708; Q16860; Q6FHN1; Q6NSA3; Q96Q81" "Pyrimidine metabolism" "" "1" "0" "0.942" "1.121" "1.108" "0.927" "0.890" "0.926" "1.038" "0.926" "0.605" "1281.3" "1207.1" "1436.7" "1419.7" "1187.5" "1140.2" "1187.1" "1330.6" "1185.9" "774.7" "" "" "" "" "" "" "" "" "" "" "678.4" "669.2" "822.8" "653.8" "642.5" "634.3" "698.6" "726.3" "665.2" "774.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-792306396308701389" "False" "High" "IsMasterProtein" "Q9Y2W1" "Thyroid hormone receptor-associated protein 3 OS=Homo sapiens OX=9606 GN=THRAP3 PE=1 SV=2" "0.000" "False" "42.478" "14" "12" "13" "12" "955" "108.6" "10.15" "34.61" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf15440" "9967" "ENSG00000054118" "THRAP3" "D3DPS5; hsa:9967; Q5VTK6; Q9Y2W1" "Interactome of polycomb repressive complex 2 (PRC2)" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation" "3" "0" "0.893" "0.970" "1.000" "1.014" "0.982" "1.223" "1.270" "1.274" "0.728" "913.2" "815.9" "885.4" "912.8" "925.7" "896.7" "1117.0" "1159.6" "1163.1" "664.6" "" "" "" "" "" "" "" "" "" "" "483.5" "452.4" "507.1" "420.4" "500.8" "498.8" "657.4" "633.0" "652.5" "664.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6681537936157474887" "False" "High" "IsMasterProtein" "Q9UH65" "Switch-associated protein 70 OS=Homo sapiens OX=9606 GN=SWAP70 PE=1 SV=1" "0.000" "False" "42.420" "21" "15" "22" "14" "585" "69.0" "5.87" "56.57" "15" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00169" "23075" "ENSG00000133789" "SWAP70" "D3DQV1; hsa:23075; O75135; Q7LCY6; Q9P061; Q9P0Z8; Q9UH65" "" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle" "3" "1" "1.010" "1.010" "1.023" "1.001" "1.019" "0.984" "0.980" "0.973" "0.717" "2906.0" "2934.3" "2936.5" "2973.4" "2908.5" "2960.6" "2859.3" "2849.1" "2827.8" "2082.7" "" "" "" "" "" "" "" "" "" "" "1538.7" "1626.8" "1681.7" "1369.3" "1573.6" "1646.8" "1682.8" "1555.2" "1586.3" "2082.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1520164082407222722" "False" "High" "IsMasterProtein" "P07737" "Profilin-1 OS=Homo sapiens OX=9606 GN=PFN1 PE=1 SV=2" "0.000" "False" "42.226" "61" "8" "53" "6" "140" "15.0" "8.27" "118.04" "8" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00235" "5216" "ENSG00000108518" "PFN1" "hsa:5216; P07737; Q53Y44" "Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Burn wound healing; Regulation of actin cytoskeleton; G13 signaling pathway" "RHO GTPases Activate Formins; Platelet degranulation ; PCP/CE pathway; Signaling by ROBO receptors" "9" "2" "0.945" "0.978" "1.037" "0.987" "0.996" "0.986" "0.978" "0.956" "0.627" "2095.2" "1980.4" "2048.4" "2173.1" "2067.5" "2086.1" "2065.0" "2048.8" "2003.8" "1313.9" "" "" "" "" "" "" "" "" "" "" "1109.4" "1098.0" "1173.1" "1000.8" "1118.6" "1160.4" "1215.3" "1118.4" "1124.1" "1313.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6019619507196981202" "False" "High" "IsMasterProtein" "P61158" "Actin-related protein 3 OS=Homo sapiens OX=9606 GN=ACTR3 PE=1 SV=3" "0.000" "False" "42.173" "24" "10" "23" "7" "418" "47.3" "5.88" "62.18" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "10096" "ENSG00000115091" "ACTR3" "hsa:10096; P32391; P61158; Q53QM2" "Physico-chemical features and toxicity-associated pathways" "EPHB-mediated forward signaling; FCGR3A-mediated phagocytosis; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis" "6" "3" "1.010" "0.917" "1.001" "0.992" "1.014" "1.056" "0.999" "1.088" "0.583" "1510.6" "1525.6" "1384.4" "1512.1" "1498.4" "1531.0" "1594.5" "1509.0" "1643.5" "880.0" "" "" "" "" "" "" "" "" "" "" "799.8" "845.8" "792.9" "696.4" "810.7" "851.6" "938.4" "823.7" "922.0" "880.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8498450919961846637" "False" "High" "IsMasterProtein" "Q14315" "Filamin-C OS=Homo sapiens OX=9606 GN=FLNC PE=1 SV=3" "0.000" "False" "42.139" "4" "10" "13" "1" "2725" "290.8" "5.97" "38.23" "10" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00630" "2318" "ENSG00000128591" "FLNC" "B2ZZ88; hsa:2318; O95303; Q07985; Q14315; Q9NS12; Q9NYE5; Q9UMR8; Q9Y503" "Focal adhesion; MAPK signaling pathway; Ebola virus infection in host; NPHP1 deletion syndrome; 13q12.12 copy number variation" "Cell-extracellular matrix interactions" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4399142244827454415" "False" "High" "IsMasterProtein" "Q8NFD5" "AT-rich interactive domain-containing protein 1B OS=Homo sapiens OX=9606 GN=ARID1B PE=1 SV=3" "0.000" "False" "42.023" "5" "9" "10" "9" "2319" "243.8" "6.90" "34.13" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01388, Pf12031" "57492" "ENSG00000049618" "ARID1B" "hsa:57492; Q5JRD1; Q5VYC4; Q8IZY8; Q8NFD5; Q8TEV0; Q8TF02; Q99491; Q9ULI5" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "6" "0" "1.011" "1.036" "1.142" "1.019" "1.004" "1.293" "1.073" "1.178" "3.218" "519.5" "525.3" "538.1" "593.5" "529.3" "521.5" "671.5" "557.4" "611.8" "1671.8" "" "" "" "" "" "" "" "" "" "" "275.1" "291.3" "308.2" "273.3" "286.4" "290.1" "395.2" "304.3" "343.2" "1671.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4388967430464997560" "False" "High" "IsMasterProtein" "P43034" "Platelet-activating factor acetylhydrolase IB subunit beta OS=Homo sapiens OX=9606 GN=PAFAH1B1 PE=1 SV=2" "0.000" "False" "42.000" "26" "9" "12" "8" "410" "46.6" "7.37" "34.85" "9" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08513" "5048" "ENSG00000007168" "PAFAH1B1" "B2R7Q7; hsa:5048; P43034; Q8WZ88; Q8WZ89" "Wnt signaling pathway and pluripotency; Ciliary landscape; Neurogenesis regulation in the olfactory epithelium; PAFAH1B1 copy number variation" "AURKA Activation by TPX2; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; Separation of Sister Chromatids; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "18" "0" "1.001" "0.982" "0.938" "1.041" "1.072" "0.970" "0.999" "0.913" "0.715" "812.6" "813.0" "798.2" "762.0" "846.2" "870.9" "788.6" "812.0" "741.9" "581.1" "" "" "" "" "" "" "" "" "" "" "430.2" "450.8" "457.1" "350.9" "457.8" "484.4" "464.1" "443.2" "416.2" "581.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5554010069989842743" "False" "High" "IsMasterProtein" "Q9BZZ5" "Apoptosis inhibitor 5 OS=Homo sapiens OX=9606 GN=API5 PE=1 SV=3" "0.000" "False" "41.955" "16" "8" "18" "8" "524" "59.0" "7.34" "47.72" "8" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf05918" "8539" "ENSG00000166181" "API5" "B4DGR0; B4DRJ2; B4E283; D3DR21; G3V1C3; hsa:8539; O15441; Q9BZZ5; Q9Y4J7" "" "" "0" "0" "1.009" "0.970" "1.032" "1.069" "0.970" "1.009" "1.087" "1.011" "0.554" "885.6" "893.3" "858.9" "913.9" "946.3" "859.4" "893.7" "962.2" "895.4" "490.3" "" "" "" "" "" "" "" "" "" "" "468.9" "495.3" "491.9" "420.9" "512.0" "478.0" "526.0" "525.2" "502.3" "490.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4375122853346024923" "False" "High" "IsMasterProtein" "Q9C0E2" "Exportin-4 OS=Homo sapiens OX=9606 GN=XPO4 PE=1 SV=2" "0.000" "False" "41.869" "8" "9" "17" "8" "1151" "130.1" "5.05" "52.43" "9" "transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08767" "64328" "ENSG00000132953" "XPO4" "hsa:64328; Q5VUZ5; Q8N3V6; Q9C0E2; Q9H934" "eIF5A regulation in response to inhibition of the nuclear export system" "" "1" "1" "1.034" "0.990" "1.009" "1.049" "1.082" "1.024" "1.040" "1.055" "0.878" "1119.8" "1157.8" "1108.2" "1130.1" "1174.3" "1212.1" "1146.7" "1164.6" "1181.7" "982.8" "" "" "" "" "" "" "" "" "" "" "592.9" "641.9" "634.6" "520.5" "635.4" "674.2" "674.9" "635.7" "662.9" "982.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8832352295829315313" "False" "High" "IsMasterProtein" "P09622" "Dihydrolipoyl dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=DLD PE=1 SV=2" "0.000" "False" "41.858" "21" "11" "16" "11" "509" "54.1" "7.85" "37.63" "11" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02852, Pf07992" "1738" "ENSG00000091140" "DLD" "B2R5X0; B4DHG0; B4DT69; hsa:1738; P09622; Q14131; Q14167; Q59EV8; Q8WTS4" "Fatty acid beta-oxidation; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Tryptophan metabolism; 7q11.23 copy number variation syndrome; Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis; 10q11.21q11.23 copy number variation syndrome; Metabolic Epileptic Disorders; TCA cycle (aka Krebs or citric acid cycle)" "Lysine catabolism; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Citric acid cycle (TCA cycle); Branched-chain amino acid catabolism; Mitochondrial protein degradation; Glycine degradation" "19" "0" "0.933" "0.923" "0.849" "0.873" "0.897" "0.927" "0.901" "0.860" "0.393" "2163.7" "2017.7" "1997.9" "1836.2" "1888.1" "1940.1" "2006.7" "1948.5" "1860.5" "849.4" "" "" "" "" "" "" "" "" "" "" "1145.7" "1118.7" "1144.2" "845.6" "1021.6" "1079.2" "1181.0" "1063.6" "1043.7" "849.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2088102652964782572" "False" "High" "IsMasterProtein" "Q13310" "Polyadenylate-binding protein 4 OS=Homo sapiens OX=9606 GN=PABPC4 PE=1 SV=1" "0.000" "False" "41.802" "15" "9" "15" "5" "644" "70.7" "9.26" "36.16" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf00658" "8761" "ENSG00000090621" "PABPC4" "B1ANQ8; hsa:8761; Q13310; Q4VC03; Q6P0N3" "" "" "0" "0" "1.081" "1.021" "1.130" "1.197" "1.067" "1.045" "0.875" "0.946" "1.648" "413.4" "446.7" "422.1" "467.2" "494.8" "441.0" "432.0" "361.6" "391.1" "681.5" "" "" "" "" "" "" "" "" "" "" "218.9" "247.7" "241.7" "215.2" "267.7" "245.3" "254.2" "197.4" "219.4" "681.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6585678134614880292" "False" "High" "IsMasterProtein" "Q9NTK5" "Obg-like ATPase 1 OS=Homo sapiens OX=9606 GN=OLA1 PE=1 SV=2" "0.000" "False" "41.767" "23" "9" "18" "9" "396" "44.7" "7.81" "48.07" "9" "other metabolic processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "translation activity;other molecular function" "Pf01926, Pf06071" "29789" "ENSG00000138430" "OLA1" "D7EHM2; hsa:29789; Q5BJD7; Q8NCI8; Q96CU1; Q96SV2; Q9NTK5; Q9P1D3; Q9UNY9; Q9Y6G4" "" "Platelet degranulation" "1" "0" "0.965" "0.966" "1.011" "0.934" "0.963" "0.876" "0.851" "0.887" "0.653" "841.3" "811.9" "812.8" "850.4" "785.5" "809.7" "736.8" "715.7" "746.0" "549.5" "" "" "" "" "" "" "" "" "" "" "445.4" "450.2" "465.5" "391.6" "425.0" "450.4" "433.7" "390.7" "418.5" "549.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8024352083789976777" "False" "High" "IsMasterProtein" "Q9UKV3" "Apoptotic chromatin condensation inducer in the nucleus OS=Homo sapiens OX=9606 GN=ACIN1 PE=1 SV=2" "0.000" "False" "41.736" "7" "9" "11" "9" "1341" "151.8" "6.43" "36.73" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf16294" "22985" "ENSG00000100813" "ACIN1" "B2RTT4; D3DS45; hsa:22985; O75158; Q9UG91; Q9UKV1; Q9UKV2; Q9UKV3" "" "mRNA Splicing - Major Pathway; Apoptotic cleavage of cellular proteins" "2" "0" "0.979" "1.068" "1.025" "1.069" "1.028" "1.522" "1.620" "1.487" "0.657" "1169.0" "1144.6" "1248.5" "1198.1" "1249.3" "1202.3" "1779.4" "1893.8" "1737.8" "768.5" "" "" "" "" "" "" "" "" "" "" "619.0" "634.6" "715.0" "551.8" "675.9" "668.8" "1047.2" "1033.8" "974.9" "768.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8312610725791659305" "False" "High" "IsMasterProtein" "P17812" "CTP synthase 1 OS=Homo sapiens OX=9606 GN=CTPS1 PE=1 SV=2" "0.000" "False" "41.620" "18" "11" "19" "9" "591" "66.6" "6.46" "56.90" "11" "cell cycle OR cell proliferation;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00117, Pf06418, Pf07722" "1503" "ENSG00000171793" "CTPS1" "B4DR64; D3DPW1; hsa:1503; P17812; Q5VW67; Q96GK6" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "2" "1.044" "0.981" "0.934" "1.034" "1.034" "0.941" "0.897" "0.899" "0.558" "2621.5" "2737.5" "2572.0" "2448.2" "2710.8" "2709.6" "2468.1" "2351.5" "2355.8" "1462.7" "" "" "" "" "" "" "" "" "" "" "1388.1" "1517.7" "1473.0" "1127.5" "1466.6" "1507.2" "1452.5" "1283.6" "1321.6" "1462.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5469246297971201094" "False" "High" "IsMasterProtein" "Q86TU7" "Actin-histidine N-methyltransferase OS=Homo sapiens OX=9606 GN=SETD3 PE=1 SV=1" "0.000" "False" "41.598" "14" "8" "9" "8" "594" "67.2" "5.96" "29.06" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00856, Pf09273" "84193" "ENSG00000183576" "SETD3" "A0PJU3; A5PLP0; B4DZE8; hsa:84193; Q0VAQ2; Q659C0; Q86TU7; Q86TU8; Q96GY9; Q9H5U5" "Histone modifications" "PKMTs methylate histone lysines" "2" "0" "0.948" "0.928" "0.895" "0.929" "0.988" "0.857" "0.883" "0.947" "0.615" "1751.1" "1660.9" "1625.3" "1567.1" "1627.1" "1730.3" "1501.3" "1546.4" "1658.7" "1076.1" "" "" "" "" "" "" "" "" "" "" "927.2" "920.8" "930.8" "721.7" "880.3" "962.4" "883.6" "844.1" "930.5" "1076.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4845069297566421061" "False" "High" "IsMasterProtein" "P35221" "Catenin alpha-1 OS=Homo sapiens OX=9606 GN=CTNNA1 PE=1 SV=1" "0.000" "False" "41.554" "12" "11" "16" "11" "906" "100.0" "6.29" "44.37" "11" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf01044" "1495" "ENSG00000044115" "CTNNA1" "hsa:1495; P35221; Q12795; Q8N1C0" "Arrhythmogenic right ventricular cardiomyopathy; Apoptosis-related network due to altered Notch3 in ovarian cancer; VEGFA-VEGFR2 signaling; White fat cell differentiation; Endometrial cancer; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Pleural mesothelioma" "RHO GTPases activate IQGAPs; Myogenesis; VEGFR2 mediated vascular permeability; Adherens junctions interactions; Regulation of CDH11 function; Regulation of CDH19 Expression and Function; CDH11 homotypic and heterotypic interactions" "15" "0" "1.048" "1.008" "0.972" "1.030" "1.033" "0.967" "0.972" "0.937" "0.713" "1517.0" "1589.2" "1528.6" "1474.4" "1562.9" "1567.3" "1466.7" "1474.9" "1420.7" "1081.4" "" "" "" "" "" "" "" "" "" "" "803.2" "881.1" "875.4" "679.0" "845.6" "871.8" "863.2" "805.1" "797.0" "1081.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8428260618384848940" "False" "High" "IsMasterProtein" "Q15029" "116 kDa U5 small nuclear ribonucleoprotein component OS=Homo sapiens OX=9606 GN=EFTUD2 PE=1 SV=1" "0.000" "False" "41.485" "13" "13" "21" "12" "972" "109.4" "5.00" "56.41" "13" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492, Pf16004" "9343" "ENSG00000108883" "EFTUD2" "B4DK30; B4DMC0; D3DX58; hsa:9343; K7EJ81; Q15029; Q9BUR0" "mRNA processing; Ciliary landscape" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "4" "0" "1.021" "1.053" "1.069" "1.103" "1.092" "1.122" "1.146" "1.138" "0.597" "732.1" "747.7" "771.2" "782.4" "807.5" "799.9" "821.8" "839.3" "833.5" "437.3" "" "" "" "" "" "" "" "" "" "" "387.7" "414.5" "441.7" "360.3" "436.9" "444.9" "483.7" "458.1" "467.6" "437.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7210504404319708374" "False" "High" "IsMasterProtein" "P33240" "Cleavage stimulation factor subunit 2 OS=Homo sapiens OX=9606 GN=CSTF2 PE=1 SV=1" "0.000" "False" "41.367" "18" "10" "17" "5" "577" "60.9" "6.83" "40.40" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf14304, Pf14327" "1478" "ENSG00000101811" "CSTF2" "hsa:1478; P33240; Q5H951; Q6LA74; Q8N502" "mRNA processing" "tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "6" "4" "1.004" "0.994" "1.057" "0.999" "0.957" "0.992" "1.095" "0.989" "0.633" "1637.3" "1643.6" "1627.1" "1730.6" "1635.8" "1566.1" "1624.0" "1792.9" "1619.0" "1036.2" "" "" "" "" "" "" "" "" "" "" "866.9" "911.3" "931.8" "797.0" "885.0" "871.1" "955.8" "978.6" "908.2" "1036.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7705238959085991770" "False" "High" "IsMasterProtein" "P08865" "Small ribosomal subunit protein uS2 OS=Homo sapiens OX=9606 GN=RPSA PE=1 SV=4" "0.000" "False" "41.311" "19" "5" "11" "5" "295" "32.8" "4.87" "38.61" "5" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;translational apparatus;nucleus;other cell component" "translation activity;other molecular function" "Pf00318, Pf16122" "3921" "ENSG00000168028" "RPSA" "hsa:3921; P08865; P11085; P12030; Q16471; Q6IPD1; Q6IPD2; Q6NSD1; Q6NXQ8; Q86VC0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.188" "1.132" "1.325" "1.257" "1.342" "1.410" "1.518" "1.397" "0.898" "732.2" "869.5" "828.5" "970.2" "920.2" "982.5" "1032.0" "1111.7" "1022.8" "657.4" "" "" "" "" "" "" "" "" "" "" "387.7" "482.1" "474.5" "446.8" "497.9" "546.5" "607.4" "606.9" "573.8" "657.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3951583387108982266" "False" "High" "IsMasterProtein" "P11171" "Protein 4.1 OS=Homo sapiens OX=9606 GN=EPB41 PE=1 SV=4" "0.000" "False" "41.113" "13" "10" "11" "9" "864" "97.0" "5.58" "29.91" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380" "2035" "ENSG00000159023" "EPB41" "B1ALH8; B1ALH9; D3DPM9; D3DPN0; hsa:2035; P11171; P11176; Q14245; Q5TB35; Q5VXN8; Q8IXV9; Q9Y578; Q9Y579" "VEGFA-VEGFR2 signaling; Splicing factor NOVA regulated synaptic proteins; IL-18 signaling pathway" "Neurexins and neuroligins" "4" "0" "1.051" "0.972" "1.012" "1.033" "1.149" "0.989" "1.133" "1.056" "1.053" "393.1" "413.2" "382.1" "397.9" "406.1" "451.7" "388.8" "445.5" "415.0" "414.1" "" "" "" "" "" "" "" "" "" "" "208.1" "229.1" "218.8" "183.2" "219.7" "251.3" "228.8" "243.2" "232.8" "414.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4877503792566385355" "False" "High" "IsMasterProtein" "O75822" "Eukaryotic translation initiation factor 3 subunit J OS=Homo sapiens OX=9606 GN=EIF3J PE=1 SV=2" "0.000" "False" "41.090" "34" "8" "16" "8" "258" "29.0" "4.83" "44.89" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08597" "8669" "ENSG00000104131" "EIF3J" "B4DUI3; F5H425; hsa:8669; O75822; Q9BUD2; Q9H8Q2; Q9UI65" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "0" "1.010" "1.051" "1.016" "0.968" "0.983" "0.966" "1.120" "1.044" "0.566" "1456.4" "1470.4" "1531.0" "1479.9" "1409.4" "1432.2" "1407.1" "1631.6" "1521.2" "824.1" "" "" "" "" "" "" "" "" "" "" "771.2" "815.2" "876.8" "681.5" "762.5" "796.6" "828.1" "890.6" "853.3" "824.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-877235499680530927" "False" "High" "IsMasterProtein" "Q15366" "Poly(rC)-binding protein 2 OS=Homo sapiens OX=9606 GN=PCBP2 PE=1 SV=1" "0.000" "False" "40.990" "25" "7" "14" "3" "365" "38.6" "6.79" "38.69" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013" "5094" "ENSG00000197111" "PCBP2" "A8K7X6; B4DXP5; F8VYL7; G3V0E8; hsa:5094; I6L8F9; Q15366; Q32Q82; Q59HD4; Q68Y55; Q6IPF4; Q6PKG5" "mRNA processing; Ferroptosis; Modulators of TCR signaling and T cell activation" "mRNA Splicing - Major Pathway; Negative regulators of DDX58/IFIH1 signaling; Processing of Capped Intron-Containing Pre-mRNA; SARS-CoV-1 activates/modulates innate immune responses" "7" "0" "0.973" "0.908" "0.944" "0.999" "0.961" "0.955" "0.736" "0.947" "2.754" "509.4" "495.7" "462.4" "480.8" "509.1" "489.6" "486.7" "375.1" "482.4" "1403.0" "" "" "" "" "" "" "" "" "" "" "269.7" "274.8" "264.8" "221.4" "275.4" "272.4" "286.5" "204.7" "270.6" "1403.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1361543221458196950" "False" "High" "IsMasterProtein" "O60547" "GDP-mannose 4,6 dehydratase OS=Homo sapiens OX=9606 GN=GMDS PE=1 SV=1" "0.000" "False" "40.962" "30" "12" "20" "12" "372" "41.9" "7.31" "56.04" "12" "other metabolic processes;signal transduction" "cytosol;other cell component" "other molecular function" "Pf16363" "2762" "ENSG00000112699" "GMDS" "E9PI88; hsa:2762; O60547; O75357; Q5T954; Q6FH09; Q9UGZ3; Q9UJK9" "" "GDP-fucose biosynthesis" "1" "0" "0.997" "0.972" "0.998" "1.038" "1.042" "0.961" "0.974" "0.966" "0.553" "2940.2" "2931.2" "2858.4" "2935.3" "3053.2" "3063.3" "2825.4" "2864.7" "2839.7" "1626.6" "" "" "" "" "" "" "" "" "" "" "1556.9" "1625.1" "1637.0" "1351.8" "1651.9" "1704.0" "1662.8" "1563.7" "1593.0" "1626.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3813032805198607075" "False" "High" "IsMasterProtein" "Q9NVA2" "Septin-11 OS=Homo sapiens OX=9606 GN=SEPTIN11 PE=1 SV=3" "0.000" "False" "40.942" "21" "7" "19" "4" "429" "49.4" "6.81" "44.88" "7" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00735" "55752" "ENSG00000138758" "SEPTIN11" "B7Z7Z6; E9KL32; hsa:55752; Q4W5G1; Q7L4N1; Q96SP1; Q9NVA2; Q9UFY9" "22q11.2 copy number variation syndrome" "" "1" "1" "1.025" "1.043" "1.025" "0.999" "1.083" "1.085" "1.037" "1.098" "0.634" "890.3" "912.3" "928.3" "912.1" "889.4" "964.1" "965.6" "922.9" "977.9" "564.7" "" "" "" "" "" "" "" "" "" "" "471.4" "505.8" "531.6" "420.1" "481.2" "536.3" "568.3" "503.8" "548.6" "564.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5396921561883894054" "False" "High" "IsMasterProtein" "Q96GD0" "Chronophin OS=Homo sapiens OX=9606 GN=PDXP PE=1 SV=2" "0.000" "False" "40.922" "24" "6" "10" "6" "296" "31.7" "6.55" "33.86" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf13242, Pf13344" "57026" "ENSG00000241360" "PDXP" "hsa:57026; Q96GD0; Q9UGY2" "" "" "0" "0" "1.113" "1.059" "1.085" "1.068" "1.168" "1.210" "1.067" "1.113" "0.655" "354.2" "394.4" "375.1" "384.3" "378.2" "413.8" "428.5" "377.8" "394.2" "232.0" "" "" "" "" "" "" "" "" "" "" "187.6" "218.7" "214.8" "177.0" "204.6" "230.2" "252.2" "206.2" "221.1" "232.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9080862626962095597" "False" "High" "IsMasterProtein" "O75312" "Zinc finger protein ZPR1 OS=Homo sapiens OX=9606 GN=ZPR1 PE=1 SV=1" "0.000" "False" "40.899" "19" "8" "10" "8" "459" "50.9" "4.73" "32.03" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf03367" "8882" "ENSG00000109917" "ZPR1" "hsa:8882; O75312; Q2TAA0" "" "" "0" "0" "1.135" "1.165" "0.950" "1.137" "1.144" "1.105" "1.313" "1.192" "0.981" "702.8" "797.4" "818.7" "667.6" "799.0" "803.8" "776.4" "922.7" "838.0" "689.5" "" "" "" "" "" "" "" "" "" "" "372.1" "442.1" "468.9" "307.4" "432.3" "447.1" "456.9" "503.7" "470.1" "689.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8166763961734876416" "False" "High" "IsMasterProtein" "P54727" "UV excision repair protein RAD23 homolog B OS=Homo sapiens OX=9606 GN=RAD23B PE=1 SV=1" "0.000" "False" "40.870" "21" "8" "23" "6" "409" "43.1" "4.84" "57.16" "8" "protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00627, Pf09280" "5887" "ENSG00000119318" "RAD23B" "B3KWK8; G5E9P0; hsa:5887; P54727; Q7Z5K8; Q8WUB0" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; HDAC6 interactions in the central nervous system" "Josephin domain DUBs; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "8" "2" "1.006" "1.035" "1.079" "1.015" "0.906" "0.987" "1.155" "0.961" "0.503" "2334.2" "2348.3" "2416.9" "2519.7" "2370.1" "2114.2" "2303.0" "2695.7" "2243.3" "1174.8" "" "" "" "" "" "" "" "" "" "" "1236.0" "1302.0" "1384.1" "1160.4" "1282.3" "1176.0" "1355.4" "1471.4" "1258.4" "1174.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3625950205882740020" "False" "High" "IsMasterProtein" "Q9NWQ8" "Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 OS=Homo sapiens OX=9606 GN=PAG1 PE=1 SV=2" "0.000" "False" "40.753" "27" "9" "9" "9" "432" "47.0" "4.65" "26.96" "9" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf15347" "55824" "ENSG00000076641" "PAG1" "A8K1A3; hsa:55824; Q2M1Z9; Q5BKU4; Q9NWQ8; Q9NYK0" "" "Phosphorylation of CD3 and TCR zeta chains; GAB1 signalosome" "2" "0" "1.025" "1.124" "1.185" "1.073" "1.034" "1.134" "1.204" "1.147" "0.536" "602.0" "616.9" "676.7" "713.4" "646.0" "622.3" "682.5" "724.6" "690.7" "322.4" "" "" "" "" "" "" "" "" "" "" "318.8" "342.0" "387.6" "328.5" "349.5" "346.1" "401.7" "395.5" "387.4" "322.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4660808662127601060" "False" "High" "IsMasterProtein" "Q9NR09" "Baculoviral IAP repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=BIRC6 PE=1 SV=3" "0.000" "False" "40.610" "2" "12" "13" "12" "4857" "529.9" "6.05" "35.60" "12" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00179, Pf00653, Pf12356" "57448" "ENSG00000115760" "BIRC6" "hsa:57448; Q9NR09; Q9ULD1" "" "ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants" "2" "0" "1.017" "1.014" "1.019" "1.101" "1.081" "0.988" "0.917" "0.967" "1.163" "998.5" "1015.3" "1013.0" "1017.9" "1099.2" "1079.5" "986.1" "915.5" "965.4" "1161.5" "" "" "" "" "" "" "" "" "" "" "528.7" "562.9" "580.1" "468.8" "594.7" "600.5" "580.3" "499.7" "541.6" "1161.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8952953409399985954" "False" "High" "IsMasterProtein" "Q9H1E3" "Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 OS=Homo sapiens OX=9606 GN=NUCKS1 PE=1 SV=1" "0.000" "False" "40.565" "48" "9" "16" "9" "243" "27.3" "5.08" "44.37" "9" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "64710" "ENSG00000069275" "NUCKS1" "hsa:64710; Q54AC0; Q5PXE7; Q9H1D6; Q9H1E3; Q9H723" "" "" "0" "0" "0.867" "1.091" "0.871" "0.909" "0.848" "0.888" "0.935" "0.954" "0.434" "1977.9" "1714.5" "2157.9" "1723.4" "1798.3" "1678.2" "1756.1" "1848.7" "1885.9" "859.2" "" "" "" "" "" "" "" "" "" "" "1047.3" "950.6" "1235.8" "793.7" "972.9" "933.5" "1033.5" "1009.1" "1058.0" "859.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3988620745573507049" "False" "High" "IsMasterProtein" "P55786" "Puromycin-sensitive aminopeptidase OS=Homo sapiens OX=9606 GN=NPEPPS PE=1 SV=2" "0.000" "False" "40.539" "13" "13" "28" "13" "919" "103.2" "5.72" "72.28" "13" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf01433, Pf11838, Pf17900" "9520" "ENSG00000141279" "NPEPPS" "B7Z463; hsa:9520; P55786; Q6P145; Q9NP16; Q9UEM2" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.011" "0.968" "1.036" "1.006" "1.027" "1.028" "1.001" "1.011" "0.726" "2093.1" "2116.5" "2025.5" "2169.2" "2105.2" "2150.7" "2152.7" "2095.9" "2116.4" "1518.9" "" "" "" "" "" "" "" "" "" "" "1108.3" "1173.4" "1160.0" "999.0" "1139.0" "1196.3" "1266.9" "1144.1" "1187.3" "1518.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-93919318191628628" "False" "High" "IsMasterProtein" "Q92499" "ATP-dependent RNA helicase DDX1 OS=Homo sapiens OX=9606 GN=DDX1 PE=1 SV=2" "0.000" "False" "40.517" "16" "11" "13" "11" "740" "82.4" "7.23" "40.01" "11" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf00622" "1653" "ENSG00000079785" "DDX1" "B4DME8; B4DPN6; hsa:1653; Q92499" "DDX1 as a regulatory component of the Drosha microprocessor; mRNA processing" "tRNA processing in the nucleus" "3" "0" "0.992" "0.980" "0.929" "0.963" "1.017" "0.892" "0.770" "0.909" "2.227" "1418.3" "1406.7" "1390.6" "1317.9" "1366.3" "1442.5" "1264.8" "1092.6" "1289.9" "3159.1" "" "" "" "" "" "" "" "" "" "" "751.0" "779.9" "796.4" "606.9" "739.2" "802.4" "744.4" "596.4" "723.6" "3159.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3827413943900730422" "False" "High" "IsMasterProtein" "Q9Y2W2" "WW domain-binding protein 11 OS=Homo sapiens OX=9606 GN=WBP11 PE=1 SV=1" "0.000" "False" "40.411" "13" "8" "15" "8" "641" "70.0" "8.38" "38.72" "8" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09429" "51729" "ENSG00000084463" "WBP11" "hsa:51729; Q96AY8; Q9Y2W2" "" "mRNA Splicing - Major Pathway" "1" "0" "1.037" "1.036" "1.016" "1.067" "1.032" "1.043" "1.123" "1.142" "0.621" "1469.2" "1523.2" "1522.4" "1492.7" "1567.2" "1515.7" "1532.3" "1649.8" "1678.1" "913.0" "" "" "" "" "" "" "" "" "" "" "778.0" "844.5" "871.9" "687.4" "847.9" "843.1" "901.8" "900.6" "941.4" "913.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5365621191326057651" "False" "High" "IsMasterProtein" "P54819" "Adenylate kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=AK2 PE=1 SV=2" "0.000" "False" "40.309" "31" "8" "21" "8" "239" "26.5" "7.81" "60.00" "8" "other metabolic processes" "cytoskeleton;mitochondrion;other cell component" "kinase activity;other molecular function" "Pf00406, Pf05191" "204" "ENSG00000004455" "AK2" "A8K6L1; B4DHH7; B4DL64; hsa:204; P54819; Q16856; Q5EB54; Q5TIF7; Q8TCY2; Q8TCY3" "" "Interconversion of nucleotide di- and triphosphates" "1" "0" "0.948" "1.021" "1.057" "1.027" "1.036" "0.958" "1.070" "1.097" "0.540" "1954.7" "1852.7" "1996.1" "2065.4" "2007.6" "2025.5" "1872.7" "2091.7" "2145.0" "1055.7" "" "" "" "" "" "" "" "" "" "" "1035.0" "1027.2" "1143.1" "951.2" "1086.2" "1126.7" "1102.1" "1141.8" "1203.3" "1055.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4797790429512717329" "False" "High" "IsMasterProtein" "O75874" "Isocitrate dehydrogenase [NADP] cytoplasmic OS=Homo sapiens OX=9606 GN=IDH1 PE=1 SV=2" "0.000" "False" "40.278" "21" "9" "18" "8" "414" "46.6" "7.01" "49.48" "9" "other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00180" "3417" "ENSG00000138413" "IDH1" "hsa:3417; O75874; Q567U4; Q6FHQ6; Q7Z3V0; Q93090; Q9NTJ9; Q9UKW8" "Glutathione metabolism; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism" "Peroxisomal protein import; Neutrophil degranulation; Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate; NADPH regeneration; NFE2L2 regulating TCA cycle genes" "8" "0" "0.942" "0.912" "0.887" "0.993" "0.988" "0.905" "0.922" "0.931" "0.521" "1185.0" "1116.2" "1080.2" "1051.3" "1176.6" "1170.9" "1072.0" "1092.7" "1103.8" "616.8" "" "" "" "" "" "" "" "" "" "" "627.4" "618.9" "618.6" "484.2" "636.6" "651.3" "630.9" "596.5" "619.2" "616.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7598274604461767952" "False" "High" "IsMasterProtein" "P49750" "YLP motif-containing protein 1 OS=Homo sapiens OX=9606 GN=YLPM1 PE=1 SV=4" "0.000" "False" "40.202" "6" "13" "16" "13" "2146" "241.5" "6.55" "41.59" "13" "other biological processes" "nucleus" "" "Pf13671" "56252" "ENSG00000119596" "YLPM1" "hsa:56252; P49750; P49752; Q96I64; Q9P1V7" "" "" "0" "0" "0.962" "0.978" "1.017" "1.026" "1.028" "1.151" "1.288" "1.238" "0.802" "1436.1" "1381.2" "1404.3" "1460.8" "1473.9" "1476.9" "1652.8" "1850.0" "1778.2" "1152.4" "" "" "" "" "" "" "" "" "" "" "760.4" "765.8" "804.3" "672.8" "797.5" "821.5" "972.7" "1009.8" "997.5" "1152.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1724337932377857957" "False" "High" "IsMasterProtein" "Q13619" "Cullin-4A OS=Homo sapiens OX=9606 GN=CUL4A PE=1 SV=3" "0.000" "False" "40.150" "10" "9" "18" "3" "759" "87.6" "8.13" "53.24" "9" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8451" "ENSG00000139842" "CUL4A" "A2A2W2; hsa:8451; O75834; Q13619; Q589T6; Q5TC62; Q6UP08; Q9UP17" "Hippo-Merlin signaling dysregulation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Neddylation; Formation of Incision Complex in GG-NER; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; DNA Damage Recognition in GG-NER; Dual Incision in GG-NER" "13" "0" "0.905" "0.902" "0.833" "0.851" "0.850" "0.846" "0.811" "0.901" "1.739" "246.4" "223.0" "222.3" "205.3" "209.6" "209.5" "208.4" "199.7" "221.9" "428.4" "" "" "" "" "" "" "" "" "" "" "130.4" "123.7" "127.3" "94.5" "113.4" "116.5" "122.7" "109.0" "124.5" "428.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5272844491039920934" "False" "High" "IsMasterProtein" "P09661" "U2 small nuclear ribonucleoprotein A' OS=Homo sapiens OX=9606 GN=SNRPA1 PE=1 SV=2" "0.000" "False" "40.121" "25" "6" "10" "6" "255" "28.4" "8.62" "36.32" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf14580" "6627" "ENSG00000131876" "SNRPA1" "B2R5I6; hsa:6627; P09661; Q8TBD2" "mRNA processing" "mRNA Splicing - Major Pathway; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "3" "0" "1.058" "1.101" "1.116" "1.116" "1.132" "1.031" "1.139" "1.046" "0.669" "876.8" "927.6" "965.5" "978.4" "978.7" "992.4" "904.0" "998.2" "917.2" "586.7" "" "" "" "" "" "" "" "" "" "" "464.2" "514.3" "552.9" "450.6" "529.5" "552.0" "532.1" "544.9" "514.5" "586.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4685450292699183556" "False" "High" "IsMasterProtein" "P43246" "DNA mismatch repair protein Msh2 OS=Homo sapiens OX=9606 GN=MSH2 PE=1 SV=1" "0.000" "False" "40.008" "11" "10" "11" "10" "934" "104.7" "5.77" "29.53" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00488, Pf01624, Pf05188, Pf05190, Pf05192" "4436" "ENSG00000095002" "MSH2" "B4E2Z2; hsa:4436; O75488; P43246" "RAC1/PAK1/p38/MMP2 pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ciliary landscape; DNA repair pathways, full network; p53 transcriptional gene network; DNA mismatch repair" "TP53 Regulates Transcription of DNA Repair Genes; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MSH3; Defective Mismatch Repair Associated With MSH2; Defective Mismatch Repair Associated With MSH6" "12" "0" "0.962" "1.012" "1.017" "0.931" "1.011" "0.987" "0.793" "0.934" "2.858" "1076.4" "1035.5" "1088.9" "1095.2" "1002.0" "1088.7" "1062.2" "853.9" "1005.2" "3076.1" "" "" "" "" "" "" "" "" "" "" "570.0" "574.1" "623.6" "504.4" "542.1" "605.6" "625.2" "466.1" "563.9" "3076.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3249613255715037073" "False" "High" "IsMasterProtein" "P30041" "Peroxiredoxin-6 OS=Homo sapiens OX=9606 GN=PRDX6 PE=1 SV=3" "0.000" "False" "39.966" "38" "8" "28" "8" "224" "25.0" "6.38" "77.44" "8" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00578, Pf10417" "9588" "ENSG00000117592" "PRDX6" "A8JZY7; hsa:9588; P30041; P32077; Q5TAH4; Q5ZEZ8" "Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling" "Neutrophil degranulation; Detoxification of Reactive Oxygen Species" "5" "0" "0.983" "1.037" "1.041" "1.086" "1.077" "1.055" "1.064" "0.990" "0.607" "2221.6" "2184.6" "2304.0" "2312.1" "2413.7" "2392.6" "2344.3" "2363.1" "2200.1" "1349.6" "" "" "" "" "" "" "" "" "" "" "1176.3" "1211.2" "1319.5" "1064.8" "1305.9" "1330.9" "1379.7" "1289.9" "1234.2" "1349.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1449875230825116072" "False" "High" "IsMasterProtein" "Q03252" "Lamin-B2 OS=Homo sapiens OX=9606 GN=LMNB2 PE=1 SV=4" "0.000" "False" "39.883" "20" "13" "19" "12" "620" "69.9" "5.59" "48.38" "13" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00038, Pf00932" "84823" "ENSG00000176619" "LMNB2" "hsa:84823; O75292; Q03252; Q14734; Q96DF6" "Gastric cancer network 2; Fas ligand pathway and stress induction of heat shock proteins; IL-18 signaling pathway; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome" "" "6" "0" "0.966" "0.987" "1.202" "1.255" "1.138" "2.411" "2.688" "2.421" "0.952" "476.7" "460.4" "470.6" "572.9" "598.4" "542.4" "1149.2" "1281.4" "1154.1" "453.7" "" "" "" "" "" "" "" "" "" "" "252.4" "255.3" "269.5" "263.8" "323.8" "301.7" "676.4" "699.5" "647.4" "453.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8623682461858759698" "False" "High" "IsMasterProtein" "P54578" "Ubiquitin carboxyl-terminal hydrolase 14 OS=Homo sapiens OX=9606 GN=USP14 PE=1 SV=3" "0.000" "False" "39.861" "21" "10" "19" "10" "494" "56.0" "5.30" "45.02" "10" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00443" "9097" "ENSG00000101557" "USP14" "B7Z4N8; hsa:9097; J3QRZ5; P54578; Q53XY5" "" "Ub-specific processing proteases; Regulation of NF-kappa B signaling" "2" "0" "0.986" "1.035" "1.000" "1.059" "1.015" "1.029" "0.943" "1.042" "1.600" "1096.2" "1080.5" "1134.9" "1096.7" "1161.2" "1112.5" "1128.3" "1034.3" "1141.9" "1754.0" "" "" "" "" "" "" "" "" "" "" "580.5" "599.1" "649.9" "505.1" "628.3" "618.8" "664.0" "564.6" "640.6" "1754.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3363379489977265255" "False" "High" "IsMasterProtein" "P00441" "Superoxide dismutase [Cu-Zn] OS=Homo sapiens OX=9606 GN=SOD1 PE=1 SV=2" "0.000" "False" "39.712" "44" "7" "15" "7" "154" "15.9" "6.13" "43.55" "7" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00080" "6647" "ENSG00000142168" "SOD1" "A6NHJ0; D3DSE4; P00441; Q16669; Q16711; Q16838; Q16839; Q16840; Q6NR85" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; AGE/RAGE pathway; Dopamine metabolism; Amyotrophic lateral sclerosis (ALS); Trans-sulfuration, one-carbon metabolism and related pathways; Copper homeostasis; Physico-chemical features and toxicity-associated pathways; One-carbon metabolism and related pathways; Oxidative stress response; Extracellular vesicles in the crosstalk of cardiac cells; Arsenic metabolism and reactive oxygen species generation; HDAC6 interactions in the central nervous system" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Platelet degranulation ; Detoxification of Reactive Oxygen Species" "17" "0" "0.815" "1.022" "1.031" "0.676" "0.824" "0.823" "0.977" "0.867" "0.380" "2365.8" "1928.1" "2418.8" "2438.2" "1598.8" "1949.3" "1947.2" "2312.3" "2051.1" "899.5" "" "" "" "" "" "" "" "" "" "" "1252.7" "1069.0" "1385.2" "1122.9" "865.0" "1084.3" "1146.0" "1262.2" "1150.6" "899.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1699375806796057255" "False" "High" "IsMasterProtein" "Q6IA69" "Glutamine-dependent NAD(+) synthetase OS=Homo sapiens OX=9606 GN=NADSYN1 PE=1 SV=3" "0.000" "False" "39.706" "14" "8" "9" "8" "706" "79.2" "6.44" "27.30" "8" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00795, Pf02540" "55191" "ENSG00000172890" "NADSYN1" "B3KUU4; hsa:55191; Q6IA69; Q86SN2; Q9HA25; Q9NVM8" "NAD biosynthesis II (from tryptophan); NAD+ biosynthetic pathways" "Nicotinate metabolism" "3" "0" "1.116" "1.052" "1.123" "1.022" "1.127" "1.106" "1.092" "1.069" "0.718" "618.6" "690.6" "650.6" "694.4" "632.0" "697.1" "684.5" "675.3" "661.6" "444.4" "" "" "" "" "" "" "" "" "" "" "327.5" "382.9" "372.6" "319.8" "341.9" "387.8" "402.8" "368.6" "371.1" "444.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4706681870966743539" "False" "High" "IsMasterProtein" "Q9BWU0" "Kanadaptin OS=Homo sapiens OX=9606 GN=SLC4A1AP PE=1 SV=2" "0.000" "False" "39.611" "12" "7" "7" "7" "742" "82.8" "5.10" "25.20" "7" "" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf00035, Pf00498" "22950" "ENSG00000163798" "SLC4A1AP" "A0A087X0M4; A6NJ39; hsa:22950; Q4KMT1; Q4KMX0; Q7Z5Q9; Q9BWU0; Q9NVN2" "" "" "0" "0" "1.106" "0.947" "0.901" "1.001" "1.011" "1.116" "1.047" "1.166" "1.562" "751.3" "831.0" "711.5" "677.0" "751.8" "759.3" "838.5" "786.5" "875.7" "1173.5" "" "" "" "" "" "" "" "" "" "" "397.8" "460.7" "407.5" "311.8" "406.8" "422.3" "493.5" "429.3" "491.3" "1173.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8135854214922228039" "False" "High" "IsMasterProtein" "Q9BY44" "Eukaryotic translation initiation factor 2A OS=Homo sapiens OX=9606 GN=EIF2A PE=1 SV=3" "0.000" "False" "39.571" "20" "11" "15" "11" "585" "64.9" "8.87" "35.52" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;nucleic acid binding activity" "Pf08662" "83939" "ENSG00000144895" "EIF2A" "A8MPS6; B4DF96; B4DQ14; D3DNI9; hsa:83939; Q5QTR2; Q7Z4E9; Q8NFM1; Q96EW9; Q96K81; Q9BY44" "Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling; 7q11.23 copy number variation syndrome" "" "3" "0" "0.998" "1.056" "1.050" "0.953" "0.978" "0.900" "1.061" "0.945" "0.869" "795.4" "793.8" "839.7" "835.2" "758.2" "777.8" "715.6" "843.7" "751.5" "691.3" "" "" "" "" "" "" "" "" "" "" "421.2" "440.1" "480.9" "384.6" "410.2" "432.7" "421.2" "460.5" "421.6" "691.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3480641512252917896" "False" "High" "IsMasterProtein" "Q9NRF8" "CTP synthase 2 OS=Homo sapiens OX=9606 GN=CTPS2 PE=1 SV=1" "0.000" "False" "39.561" "14" "8" "12" "6" "586" "65.6" "6.90" "40.14" "8" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00117, Pf06418, Pf07722" "56474" "ENSG00000047230" "CTPS2" "B3KWM2; hsa:56474; Q9BRI0; Q9H809; Q9H8K9; Q9NRF8" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "1.049" "0.940" "1.008" "0.999" "1.044" "0.987" "0.913" "0.924" "0.552" "723.7" "759.2" "680.0" "729.2" "722.9" "755.8" "714.1" "660.5" "669.0" "399.2" "" "" "" "" "" "" "" "" "" "" "383.2" "420.9" "389.4" "335.8" "391.1" "420.4" "420.3" "360.6" "375.3" "399.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4866414538171077072" "False" "High" "IsMasterProtein" "P31146" "Coronin-1A OS=Homo sapiens OX=9606 GN=CORO1A PE=1 SV=4" "0.000" "False" "39.504" "20" "10" "12" "10" "461" "51.0" "6.68" "37.42" "10" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08953, Pf08954, Pf16300" "11151" "ENSG00000102879" "CORO1A" "B2RBL1; hsa:11151; P31146; Q2YD73" "16p11.2 proximal deletion syndrome" "Prevention of phagosomal-lysosomal fusion" "2" "0" "1.111" "1.022" "1.081" "1.063" "1.126" "1.013" "0.410" "1.062" "8.376" "865.0" "961.0" "884.4" "935.2" "919.6" "973.6" "876.5" "354.2" "918.7" "7245.2" "" "" "" "" "" "" "" "" "" "" "458.0" "532.8" "506.5" "430.7" "497.5" "541.6" "515.8" "193.4" "515.4" "7245.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1718244645714628913" "False" "High" "IsMasterProtein" "Q9UIA9" "Exportin-7 OS=Homo sapiens OX=9606 GN=XPO7 PE=1 SV=3" "0.000" "False" "39.441" "10" "11" "13" "11" "1087" "123.8" "6.32" "40.56" "11" "transport" "nucleus;other cell component" "other molecular function" "Pf03810" "23039" "ENSG00000130227" "XPO7" "hsa:23039; O94846; Q6PJK9; Q8NEK7; Q9UIA9" "" "" "0" "0" "1.001" "0.920" "0.968" "0.970" "1.024" "1.052" "0.980" "0.941" "0.811" "1700.8" "1701.9" "1565.3" "1646.6" "1650.2" "1741.8" "1789.7" "1666.5" "1600.7" "1380.1" "" "" "" "" "" "" "" "" "" "" "900.6" "943.6" "896.5" "758.3" "892.8" "968.9" "1053.3" "909.7" "898.0" "1380.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7309351128836490355" "False" "High" "IsMasterProtein" "P26583" "High mobility group protein B2 OS=Homo sapiens OX=9606 GN=HMGB2 PE=1 SV=2" "0.000" "False" "39.344" "30" "7" "27" "7" "209" "24.0" "7.81" "63.57" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00505, Pf09011" "3148" "ENSG00000164104" "HMGB2" "B2R4K8; D3DP37; hsa:3148; P26583; Q5U072" "Retinoblastoma gene in cancer; Ectoderm differentiation; Ectoderm differentiation" "Apoptosis induced DNA fragmentation" "4" "0" "0.942" "1.000" "0.937" "0.883" "0.894" "0.785" "1.000" "0.914" "0.479" "2231.4" "2103.0" "2231.2" "2090.2" "1970.1" "1994.3" "1751.9" "2231.7" "2038.6" "1069.0" "" "" "" "" "" "" "" "" "" "" "1181.5" "1166.0" "1277.8" "962.6" "1065.9" "1109.3" "1031.0" "1218.2" "1143.6" "1069.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1051331415144919391" "False" "High" "IsMasterProtein" "P49189" "4-trimethylaminobutyraldehyde dehydrogenase OS=Homo sapiens OX=9606 GN=ALDH9A1 PE=1 SV=3" "0.000" "False" "39.308" "20" "9" "19" "9" "494" "53.8" "5.87" "49.68" "9" "cell organization and biogenesis;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00171" "223" "ENSG00000143149" "ALDH9A1" "B2R6X1; B4DXY7; B9EKV4; hsa:223; P49189; Q5VV90; Q6LCL1; Q9NZT7" "GABA receptor signaling; Fluoroacetic acid toxicity; Opioid receptor pathways" "Carnitine synthesis" "4" "0" "0.985" "0.956" "1.014" "0.960" "1.024" "0.976" "0.928" "0.930" "0.589" "2328.0" "2293.2" "2224.9" "2360.8" "2234.8" "2384.1" "2271.3" "2160.6" "2165.9" "1370.0" "" "" "" "" "" "" "" "" "" "" "1232.7" "1271.4" "1274.2" "1087.2" "1209.1" "1326.1" "1336.7" "1179.3" "1215.0" "1370.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2613471079569612470" "False" "High" "IsMasterProtein" "P14866" "Heterogeneous nuclear ribonucleoprotein L OS=Homo sapiens OX=9606 GN=HNRNPL PE=1 SV=2" "0.000" "False" "39.264" "24" "10" "20" "10" "589" "64.1" "8.22" "45.42" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "3191" "ENSG00000104824; ENSG00000282947" "HNRNPL" "A6ND69; A6NIT8; hsa:3191; P14866; Q9H3P3" "mRNA processing; Hippocampal synaptogenesis and neurogenesis" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "4" "0" "1.099" "1.062" "1.309" "1.184" "1.027" "1.148" "0.472" "1.035" "8.594" "264.6" "290.9" "281.0" "346.5" "313.3" "271.8" "303.7" "124.9" "274.0" "2274.2" "" "" "" "" "" "" "" "" "" "" "140.1" "161.3" "160.9" "159.6" "169.5" "151.2" "178.7" "68.2" "153.7" "2274.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3549742544018315320" "False" "High" "IsMasterProtein" "O14744" "Protein arginine N-methyltransferase 5 OS=Homo sapiens OX=9606 GN=PRMT5 PE=1 SV=4" "0.000" "False" "39.226" "17" "11" "20" "11" "637" "72.6" "6.29" "60.20" "11" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05185, Pf17285, Pf17286" "10419" "ENSG00000100462" "PRMT5" "A8MTP3; A8MZ91; B4DX49; B4DY30; B5BU10; D3DS33; E2QRE7; hsa:10419; O14744; Q6IBR1; Q9UKH1" "Transcription co-factors SKI and SKIL protein partners; Nitric oxide metabolism in cystic fibrosis" "snRNP Assembly; RMTs methylate histone arginines; Regulation of TP53 Activity through Methylation" "5" "0" "0.959" "0.988" "0.956" "0.976" "0.967" "1.014" "1.026" "0.983" "0.612" "2182.8" "2093.2" "2155.8" "2086.2" "2130.6" "2110.7" "2214.1" "2239.6" "2144.8" "1336.2" "" "" "" "" "" "" "" "" "" "" "1155.8" "1160.5" "1234.6" "960.8" "1152.7" "1174.0" "1303.1" "1222.5" "1203.2" "1336.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9124965961007810906" "False" "High" "IsMasterProtein" "P11387" "DNA topoisomerase 1 OS=Homo sapiens OX=9606 GN=TOP1 PE=1 SV=2" "0.000" "False" "39.210" "9" "9" "13" "9" "765" "90.7" "9.31" "35.36" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf01028, Pf02919, Pf14370" "7150" "ENSG00000198900" "TOP1" "A8KA78; E1P5W3; hsa:7150; O43256; P11387; Q12855; Q12856; Q15610; Q5TFY3; Q9UJN0" "Ebola virus infection in host; 15q25 copy number variation" "SUMOylation of DNA replication proteins" "3" "0" "1.081" "1.111" "1.169" "1.161" "1.156" "1.312" "0.790" "1.390" "7.272" "867.2" "937.4" "963.4" "1013.6" "1007.1" "1002.7" "1137.7" "685.1" "1205.8" "6305.7" "" "" "" "" "" "" "" "" "" "" "459.2" "519.7" "551.7" "466.8" "544.9" "557.7" "669.6" "374.0" "676.4" "6305.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6241342632728061571" "False" "High" "IsMasterProtein" "O43148" "mRNA cap guanine-N7 methyltransferase OS=Homo sapiens OX=9606 GN=RNMT PE=1 SV=1" "0.000" "False" "39.207" "20" "10" "16" "10" "476" "54.8" "6.61" "37.06" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03291" "8731" "ENSG00000101654" "RNMT" "B0YJ90; D3DUJ5; hsa:8731; O43148; O94996; Q9UIJ9" "mRNA processing; 15q25 copy number variation" "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE" "5" "0" "0.990" "1.025" "0.995" "0.897" "0.991" "0.884" "1.061" "0.970" "0.600" "1053.5" "1042.7" "1080.2" "1048.0" "945.3" "1043.5" "931.3" "1117.6" "1021.8" "631.7" "" "" "" "" "" "" "" "" "" "" "557.8" "578.1" "618.6" "482.6" "511.4" "580.5" "548.1" "610.0" "573.2" "631.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4780754661784181438" "False" "High" "IsMasterProtein" "O95373" "Importin-7 OS=Homo sapiens OX=9606 GN=IPO7 PE=1 SV=1" "0.000" "False" "39.198" "7" "6" "10" "6" "1038" "119.4" "4.82" "33.42" "6" "stress response;transport;other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf03810, Pf08506" "10527" "ENSG00000205339" "IPO7" "A6NNM5; B2R786; hsa:10527; O95373; Q1RMF7; Q9H177; Q9NTE3" "" "" "0" "0" "0.953" "0.944" "0.985" "1.000" "1.019" "1.050" "0.936" "1.038" "1.978" "1043.6" "994.6" "984.9" "1027.8" "1043.9" "1063.5" "1095.8" "976.5" "1083.4" "2064.7" "" "" "" "" "" "" "" "" "" "" "552.6" "551.4" "564.1" "473.3" "564.8" "591.6" "644.9" "533.0" "607.7" "2064.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3705631994362769923" "False" "High" "IsMasterProtein" "P11413" "Glucose-6-phosphate 1-dehydrogenase OS=Homo sapiens OX=9606 GN=G6PD PE=1 SV=4" "0.000" "False" "39.174" "21" "11" "17" "11" "515" "59.2" "6.84" "47.18" "11" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00479, Pf02781" "2539" "ENSG00000160211" "G6PD" "D3DWX9; hsa:2539; P11413; Q16000; Q16765; Q8IU70; Q8IU88; Q8IUA6; Q96PQ2" "Glutathione metabolism; Pentose phosphate metabolism; Cori cycle; Vitamin D receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; ATM signaling in development and disease ; Metabolic reprogramming in colon cancer; Vitamin D-sensitive calcium signaling in depression; Pentose phosphate pathway in senescent cells; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; Sulfation biotransformation reaction" "TP53 Regulates Metabolic Genes; NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway" "16" "0" "1.011" "0.994" "1.004" "1.014" "1.027" "0.947" "0.985" "0.965" "0.719" "1925.4" "1946.2" "1914.4" "1932.2" "1953.3" "1978.1" "1822.5" "1896.4" "1857.7" "1383.4" "" "" "" "" "" "" "" "" "" "" "1019.5" "1079.0" "1096.4" "889.8" "1056.8" "1100.3" "1072.6" "1035.2" "1042.1" "1383.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1042042739323188079" "False" "High" "IsMasterProtein" "Q9UQ35" "Serine/arginine repetitive matrix protein 2 OS=Homo sapiens OX=9606 GN=SRRM2 PE=1 SV=2" "0.000" "False" "39.046" "4" "10" "14" "10" "2752" "299.4" "12.06" "35.88" "10" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf08312" "23524" "ENSG00000167978" "SRRM2" "A6NKB9; D3DU97; hsa:23524; O15038; O94803; Q6NSL3; Q6PIM3; Q6PK40; Q8IW17; Q96GY7; Q9P0G1; Q9UHA8; Q9UQ35; Q9UQ36; Q9UQ37; Q9UQ38; Q9UQ40" "" "mRNA Splicing - Major Pathway" "1" "0" "0.977" "0.966" "1.110" "1.115" "1.002" "1.710" "1.728" "1.655" "1.031" "626.1" "612.0" "604.6" "694.9" "698.0" "627.6" "1070.4" "1081.9" "1036.2" "645.6" "" "" "" "" "" "" "" "" "" "" "331.5" "339.3" "346.3" "320.0" "377.6" "349.1" "630.0" "590.5" "581.3" "645.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6444296704773161539" "False" "High" "IsMasterProtein" "Q9NSD9" "Phenylalanine--tRNA ligase beta subunit OS=Homo sapiens OX=9606 GN=FARSB PE=1 SV=3" "0.000" "False" "38.961" "17" "11" "14" "11" "589" "66.1" "6.84" "42.72" "11" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf03483, Pf03484, Pf17759, Pf18262" "10056" "ENSG00000116120" "FARSB" "B4DFM0; hsa:10056; O95708; Q4ZFX1; Q57ZJ5; Q9NSD9; Q9NZZ6" "VEGFA-VEGFR2 signaling; Amino acid metabolism" "Cytosolic tRNA aminoacylation" "3" "0" "0.974" "0.927" "0.924" "0.997" "1.026" "0.897" "0.704" "0.937" "2.582" "1357.9" "1322.2" "1258.4" "1255.2" "1354.2" "1392.7" "1217.6" "956.6" "1271.8" "3505.5" "" "" "" "" "" "" "" "" "" "" "719.0" "733.0" "720.7" "578.0" "732.7" "774.7" "716.6" "522.2" "713.4" "3505.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8447148284608472051" "False" "High" "IsMasterProtein" "Q9H444" "Charged multivesicular body protein 4b OS=Homo sapiens OX=9606 GN=CHMP4B PE=1 SV=1" "0.000" "False" "38.767" "38" "8" "17" "8" "224" "24.9" "4.82" "50.08" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "128866" "ENSG00000101421" "CHMP4B" "E1P5N4; hsa:128866; Q53ZD6; Q9H444" "" "Sealing of the nuclear envelope (NE) by ESCRT-III; HCMV Late Events; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "9" "0" "0.983" "0.986" "1.002" "1.024" "1.004" "0.918" "1.084" "1.032" "0.508" "953.1" "936.5" "940.0" "954.9" "975.5" "957.0" "875.1" "1033.2" "983.5" "484.3" "" "" "" "" "" "" "" "" "" "" "504.7" "519.2" "538.3" "439.8" "527.8" "532.4" "515.0" "564.0" "551.7" "484.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3936479494832144237" "False" "High" "IsMasterProtein" "Q8TCS8" "Polyribonucleotide nucleotidyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PNPT1 PE=1 SV=2" "0.000" "False" "38.589" "13" "13" "19" "13" "783" "85.9" "7.77" "56.39" "13" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00575, Pf01138, Pf03725, Pf03726" "87178" "ENSG00000138035" "PNPT1" "hsa:87178; Q53SU0; Q68CN1; Q7Z7D1; Q8IWX1; Q8TCS8; Q96T05; Q9BRU3; Q9BVX0" "Pyrimidine metabolism; miRNA degrading enzymes" "Mitochondrial RNA degradation" "3" "0" "0.997" "0.958" "0.893" "0.939" "0.943" "0.793" "0.671" "0.771" "1.275" "2034.1" "2027.4" "1949.1" "1816.2" "1910.8" "1918.6" "1613.4" "1365.0" "1569.1" "2592.9" "" "" "" "" "" "" "" "" "" "" "1077.1" "1124.0" "1116.2" "836.4" "1033.8" "1067.2" "949.5" "745.1" "880.2" "2592.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1748573463469303870" "False" "High" "IsMasterProtein" "Q99661" "Kinesin-like protein KIF2C OS=Homo sapiens OX=9606 GN=KIF2C PE=1 SV=2" "0.000" "False" "38.561" "15" "9" "11" "8" "725" "81.3" "7.83" "32.06" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00225" "11004" "ENSG00000142945" "KIF2C" "B3ITR9; hsa:11004; Q5JR88; Q6ICU1; Q96C18; Q96HB8; Q99661; Q9BWV8" "Microtubule cytoskeleton regulation" "Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "10" "0" "1.034" "0.998" "1.006" "1.018" "1.094" "0.947" "0.725" "1.099" "3.511" "208.9" "216.0" "208.5" "210.3" "212.8" "228.5" "197.8" "151.5" "229.7" "733.6" "" "" "" "" "" "" "" "" "" "" "110.6" "119.8" "119.4" "96.8" "115.1" "127.1" "116.4" "82.7" "128.8" "733.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8835450799000805125" "False" "High" "IsMasterProtein" "Q8N1F7" "Nuclear pore complex protein Nup93 OS=Homo sapiens OX=9606 GN=NUP93 PE=1 SV=2" "0.000" "False" "38.528" "16" "14" "19" "14" "819" "93.4" "5.72" "42.32" "14" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf04097" "9688" "ENSG00000102900" "NUP93" "B3KPQ8; hsa:9688; Q14705; Q8N1F7" "" "ISG15 antiviral mechanism; HCMV Early Events; Regulation of HSF1-mediated heat shock response; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "29" "0" "1.104" "1.026" "1.138" "1.147" "1.135" "1.144" "0.979" "1.093" "2.459" "923.3" "1019.2" "947.0" "1050.5" "1059.0" "1048.4" "1056.2" "904.2" "1009.2" "2270.5" "" "" "" "" "" "" "" "" "" "" "488.9" "565.1" "542.3" "483.8" "573.0" "583.2" "621.6" "493.6" "566.1" "2270.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-693009755778798309" "False" "High" "IsMasterProtein" "O75396" "Vesicle-trafficking protein SEC22b OS=Homo sapiens OX=9606 GN=SEC22B PE=1 SV=5" "0.000" "False" "38.421" "34" "6" "8" "6" "215" "24.7" "8.51" "26.49" "6" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00957, Pf13774" "9554" "ENSG00000265808" "SEC22B" "A8K1G0; hsa:9554; O75396" "" "COPI-dependent Golgi-to-ER retrograde traffic; ER-Phagosome pathway; COPII-mediated vesicle transport; Cargo concentration in the ER" "4" "0" "1.061" "1.092" "1.092" "1.077" "1.154" "1.269" "1.275" "1.312" "1.105" "494.1" "524.3" "539.4" "539.7" "531.9" "570.1" "627.0" "630.2" "648.5" "546.0" "" "" "" "" "" "" "" "" "" "" "261.6" "290.7" "308.9" "248.5" "287.8" "317.1" "369.0" "344.0" "363.8" "546.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "868843744032576337" "False" "High" "IsMasterProtein" "P48444" "Coatomer subunit delta OS=Homo sapiens OX=9606 GN=ARCN1 PE=1 SV=1" "0.000" "False" "38.350" "18" "10" "12" "10" "511" "57.2" "6.21" "32.79" "10" "transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi" "" "Pf00928, Pf01217" "372" "ENSG00000095139" "ARCN1" "B4E1X2; E9PEU4; hsa:372; P48444; Q52M80" "miR-517 relationship with ARCN1 and USP1" "COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic" "3" "0" "0.980" "1.001" "1.014" "0.955" "0.987" "1.093" "0.962" "1.089" "1.056" "980.0" "960.2" "981.1" "993.3" "936.3" "967.7" "1071.1" "942.5" "1067.0" "1035.2" "" "" "" "" "" "" "" "" "" "" "518.9" "532.4" "561.9" "457.5" "506.6" "538.3" "630.4" "514.5" "598.6" "1035.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8647128743561798150" "False" "High" "IsMasterProtein" "P78417" "Glutathione S-transferase omega-1 OS=Homo sapiens OX=9606 GN=GSTO1 PE=1 SV=2" "0.000" "False" "38.297" "32" "8" "18" "8" "241" "27.5" "6.60" "45.54" "8" "other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13409, Pf14497" "9446" "ENSG00000148834" "GSTO1" "D3DRA3; F5H7H0; hsa:9446; P78417; Q5TA03; Q7Z3T2" "Myometrial relaxation and contraction pathways; Arsenic metabolism and reactive oxygen species generation; Metapathway biotransformation Phase I and II" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Glutathione conjugation; Vitamin C (ascorbate) metabolism; Methylation" "7" "0" "0.949" "0.995" "0.934" "0.960" "1.022" "0.937" "0.998" "0.937" "0.539" "1197.7" "1137.0" "1191.7" "1118.1" "1150.2" "1223.5" "1122.0" "1195.7" "1122.6" "645.1" "" "" "" "" "" "" "" "" "" "" "634.2" "630.4" "682.5" "514.9" "622.3" "680.6" "660.4" "652.7" "629.7" "645.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1146438711958021826" "False" "High" "IsMasterProtein" "Q16851" "UTP--glucose-1-phosphate uridylyltransferase OS=Homo sapiens OX=9606 GN=UGP2 PE=1 SV=5" "0.000" "False" "38.287" "21" "10" "14" "10" "508" "56.9" "8.15" "37.81" "10" "other metabolic processes;developmental processes" "cytosol;other cell component" "other molecular function" "Pf01704" "7360" "ENSG00000169764" "UGP2" "hsa:7360; Q07131; Q0P6K2; Q16851; Q86Y81; Q9BU15" "Exercise-induced circadian regulation; Glycogen synthesis and degradation; Glucuronidation" "Glycogen synthesis; Formation of the active cofactor, UDP-glucuronate" "5" "0" "0.995" "0.962" "1.007" "1.023" "1.025" "0.983" "1.023" "0.938" "0.580" "1690.1" "1681.3" "1625.1" "1702.2" "1729.7" "1733.0" "1661.2" "1728.4" "1585.4" "979.8" "" "" "" "" "" "" "" "" "" "" "894.9" "932.2" "930.7" "783.9" "935.8" "963.9" "977.7" "943.5" "889.4" "979.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4890762250346228692" "False" "High" "IsMasterProtein" "P35250" "Replication factor C subunit 2 OS=Homo sapiens OX=9606 GN=RFC2 PE=1 SV=3" "0.000" "False" "38.159" "22" "7" "14" "7" "354" "39.1" "6.44" "39.46" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004, Pf08542" "5982" "ENSG00000049541" "RFC2" "B5BU07; D3DXG3; hsa:5982; P32846; P35250; Q9BU93" "DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "27" "0" "1.016" "1.054" "1.091" "1.077" "1.054" "0.881" "0.872" "0.861" "1.227" "317.9" "322.9" "334.9" "346.8" "342.3" "335.2" "279.9" "277.2" "273.8" "389.9" "" "" "" "" "" "" "" "" "" "" "168.3" "179.0" "191.8" "159.7" "185.2" "186.4" "164.7" "151.3" "153.6" "389.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2100681429736934038" "False" "High" "IsMasterProtein" "O95218" "Zinc finger Ran-binding domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZRANB2 PE=1 SV=2" "0.000" "False" "38.143" "28" "8" "10" "8" "330" "37.4" "10.01" "32.63" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00641" "9406" "ENSG00000132485" "ZRANB2" "D3DQ75; hsa:9406; O95218; Q53GS3; Q59F92; Q5VV33; Q5VV34; Q8IXN6; Q9UP63" "" "" "0" "0" "0.946" "1.110" "0.973" "1.033" "0.938" "1.038" "1.096" "1.105" "0.619" "1424.0" "1346.6" "1580.9" "1385.7" "1471.4" "1336.3" "1477.8" "1560.6" "1573.6" "882.0" "" "" "" "" "" "" "" "" "" "" "754.0" "746.6" "905.4" "638.1" "796.1" "743.3" "869.7" "851.8" "882.8" "882.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1723896581553543701" "False" "High" "IsMasterProtein" "Q07666" "KH domain-containing, RNA-binding, signal transduction-associated protein 1 OS=Homo sapiens OX=9606 GN=KHDRBS1 PE=1 SV=1" "0.000" "False" "38.116" "14" "8" "17" "8" "443" "48.2" "8.66" "46.03" "8" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf16274, Pf16568" "10657" "ENSG00000121774" "KHDRBS1" "D3DPP3; hsa:10657; Q07666; Q6PJX7; Q8NB97; Q99760" "Leptin signaling pathway; Primary ovarian insufficiency" "PTK6 Regulates Proteins Involved in RNA Processing" "3" "0" "1.024" "1.051" "0.965" "0.940" "0.949" "0.858" "0.934" "0.928" "0.904" "1255.0" "1285.2" "1319.2" "1210.6" "1180.2" "1191.1" "1077.1" "1172.2" "1164.3" "1134.3" "" "" "" "" "" "" "" "" "" "" "664.5" "712.6" "755.5" "557.5" "638.5" "662.6" "633.9" "639.9" "653.2" "1134.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "513185524036398277" "False" "High" "IsMasterProtein" "Q9NUQ3" "Gamma-taxilin OS=Homo sapiens OX=9606 GN=TXLNG PE=1 SV=2" "0.000" "False" "37.990" "24" "12" "15" "12" "528" "60.5" "7.52" "31.94" "12" "cell cycle OR cell proliferation;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf09728" "55787" "ENSG00000086712" "TXLNG" "hsa:55787; Q2KQ75; Q5JNZ7; Q9NUQ3; Q9P0X1" "" "" "0" "0" "1.051" "1.112" "1.044" "0.979" "1.018" "0.980" "1.069" "0.972" "0.644" "1041.9" "1094.7" "1158.7" "1088.1" "1020.4" "1060.6" "1021.5" "1113.7" "1013.2" "670.6" "" "" "" "" "" "" "" "" "" "" "551.7" "606.9" "663.6" "501.1" "552.1" "590.0" "601.2" "607.9" "568.4" "670.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "92619424180281671" "False" "High" "IsMasterProtein" "Q14141" "Septin-6 OS=Homo sapiens OX=9606 GN=SEPTIN6 PE=1 SV=4" "0.000" "False" "37.968" "22" "6" "15" "3" "434" "49.7" "6.67" "34.95" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00735" "23157" "ENSG00000125354" "SEPTIN6" "hsa:23157; Q14141; Q5JTK0; Q969W5; Q96A13; Q96GR1; Q96P86; Q96P87" "2q37 copy number variation syndrome" "" "1" "0" "0.911" "1.011" "0.923" "0.961" "0.981" "0.951" "1.089" "0.940" "0.521" "513.5" "468.0" "519.3" "474.2" "493.6" "503.6" "488.4" "559.1" "482.5" "267.4" "" "" "" "" "" "" "" "" "" "" "271.9" "259.5" "297.4" "218.4" "267.1" "280.1" "287.4" "305.2" "270.7" "267.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2805084755290845876" "False" "High" "IsMasterProtein" "Q09161" "Nuclear cap-binding protein subunit 1 OS=Homo sapiens OX=9606 GN=NCBP1 PE=1 SV=1" "0.000" "False" "37.902" "13" "8" "11" "8" "790" "91.8" "6.43" "33.37" "8" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02854, Pf09088, Pf09090" "4686" "ENSG00000136937" "NCBP1" "B2R718; hsa:4686; Q09161; Q59G76; Q5T1V0; Q5T7X2" "mRNA processing; 3q29 copy number variation syndrome" "mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; RNA polymerase II transcribes snRNA genes; Processing of Intronless Pre-mRNAs; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; snRNP Assembly; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Polymerase II Pre-transcription Events; mRNA Capping; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "29" "0" "0.978" "0.974" "0.937" "0.982" "1.055" "0.985" "1.008" "1.042" "0.897" "846.2" "827.4" "824.2" "792.9" "831.2" "892.9" "833.6" "853.4" "882.1" "758.9" "" "" "" "" "" "" "" "" "" "" "448.1" "458.8" "472.0" "365.1" "449.7" "496.7" "490.6" "465.8" "494.8" "758.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8198738028437086806" "False" "High" "IsMasterProtein" "Q7Z2W4" "Zinc finger CCCH-type antiviral protein 1 OS=Homo sapiens OX=9606 GN=ZC3HAV1 PE=1 SV=3" "0.000" "False" "37.828" "10" "9" "10" "9" "902" "101.4" "8.40" "27.16" "9" "stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00644, Pf02825, Pf18606, Pf18633" "56829" "ENSG00000105939" "ZC3HAV1" "A4D1R2; A4D1S4; hsa:56829; Q7Z2W4; Q8IW57; Q8TAJ3; Q96N79; Q9H8R9; Q9P0Y7" "" "Signaling by BRAF and RAF1 fusions" "1" "0" "0.952" "1.002" "1.026" "1.108" "1.146" "1.230" "0.824" "1.194" "5.186" "471.2" "448.8" "472.1" "483.5" "522.2" "539.8" "579.7" "388.2" "562.6" "2443.6" "" "" "" "" "" "" "" "" "" "" "249.5" "248.8" "270.4" "222.7" "282.5" "300.3" "341.2" "211.9" "315.6" "2443.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6222929657638767461" "False" "High" "IsMasterProtein" "P23284" "Peptidyl-prolyl cis-trans isomerase B OS=Homo sapiens OX=9606 GN=PPIB PE=1 SV=2" "0.000" "False" "37.800" "34" "8" "27" "7" "216" "23.7" "9.41" "58.49" "8" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00160" "5479" "ENSG00000166794" "PPIB" "A8K534; hsa:5479; P23284; Q6IBH5; Q9BVK5" "Prolactin signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta" "Collagen biosynthesis and modifying enzymes; SARS-CoV-1 activates/modulates innate immune responses" "4" "0" "1.048" "1.035" "1.006" "1.044" "1.044" "0.957" "0.929" "0.964" "1.278" "1702.0" "1783.6" "1761.7" "1712.0" "1776.4" "1776.4" "1628.8" "1581.1" "1640.7" "2174.8" "" "" "" "" "" "" "" "" "" "" "901.2" "988.9" "1008.9" "788.4" "961.1" "988.1" "958.6" "863.1" "920.4" "2174.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6090154179084716209" "False" "High" "IsMasterProtein" "P36551" "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial OS=Homo sapiens OX=9606 GN=CPOX PE=1 SV=3" "0.000" "False" "37.784" "20" "8" "13" "8" "454" "50.1" "8.25" "38.10" "8" "other metabolic processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf01218" "1371" "ENSG00000080819" "CPOX" "A8K275; B4DSD5; hsa:1371; P36551; Q14060; Q53F08; Q8IZ45; Q96AF3" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "Heme biosynthesis" "3" "0" "1.020" "1.017" "1.048" "1.040" "1.039" "0.967" "0.971" "0.969" "0.568" "985.5" "1005.6" "1002.6" "1033.2" "1025.4" "1024.2" "953.3" "956.7" "955.2" "559.8" "" "" "" "" "" "" "" "" "" "" "521.8" "557.5" "574.2" "475.8" "554.8" "569.7" "561.1" "522.2" "535.9" "559.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1079834079423301401" "False" "High" "IsMasterProtein" "Q8TD19" "Serine/threonine-protein kinase Nek9 OS=Homo sapiens OX=9606 GN=NEK9 PE=1 SV=2" "0.000" "False" "37.722" "9" "8" "12" "8" "979" "107.1" "5.74" "34.62" "8" "cell cycle OR cell proliferation;other metabolic processes;other biological processes" "cytosol;nucleus" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00415, Pf13540" "91754" "ENSG00000119638" "NEK9" "hsa:91754; Q52LK6; Q8NCN0; Q8TCY4; Q8TD19; Q9UPI4; Q9Y6S4; Q9Y6S5; Q9Y6S6" "Ciliopathies" "EML4 and NUDC in mitotic spindle formation; Nuclear Pore Complex (NPC) Disassembly; Activation of NIMA Kinases NEK9, NEK6, NEK7" "4" "0" "1.021" "0.961" "1.027" "1.076" "1.029" "1.071" "1.017" "1.129" "1.024" "1098.3" "1121.1" "1055.0" "1127.7" "1182.0" "1129.7" "1176.8" "1116.8" "1240.3" "1124.9" "" "" "" "" "" "" "" "" "" "" "581.6" "621.6" "604.2" "519.3" "639.5" "628.4" "692.6" "609.6" "695.8" "1124.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1852807762900550805" "False" "High" "IsMasterProtein" "P28070" "Proteasome subunit beta type-4 OS=Homo sapiens OX=9606 GN=PSMB4 PE=1 SV=4" "0.000" "False" "37.714" "21" "4" "10" "4" "264" "29.2" "5.97" "39.09" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00227" "5692" "ENSG00000159377" "PSMB4" "B2R9L3; hsa:5692; P28070; P31148; Q5SZS5; Q6IBI4; Q969L6" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Regulation of expression of SLITs and ROBOs; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "0.948" "0.927" "0.926" "1.006" "0.986" "1.083" "1.007" "0.977" "0.573" "1250.8" "1185.1" "1159.9" "1158.3" "1258.4" "1232.9" "1355.0" "1259.1" "1222.6" "716.5" "" "" "" "" "" "" "" "" "" "" "662.3" "657.1" "664.3" "533.4" "680.8" "685.8" "797.5" "687.3" "685.8" "716.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2943690132932996841" "False" "High" "IsMasterProtein" "P10412" "Histone H1.4 OS=Homo sapiens OX=9606 GN=H1-4 PE=1 SV=2" "0.000" "False" "37.565" "26" "6" "23" "1" "219" "21.9" "11.03" "70.48" "6" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3008" "ENSG00000168298" "H1-4" "hsa:3008; P10412; Q4VB25" "Pathways affected in adenoid cystic carcinoma" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "3" "0" "0.982" "0.917" "0.895" "0.778" "0.852" "0.952" "0.905" "1.137" "0.766" "1621.9" "1593.3" "1487.5" "1451.1" "1261.9" "1382.4" "1543.4" "1467.9" "1843.5" "1242.2" "" "" "" "" "" "" "" "" "" "" "858.8" "883.4" "851.9" "668.3" "682.7" "769.0" "908.3" "801.3" "1034.1" "1242.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3079074271338885879" "False" "High" "IsMasterProtein" "P16403" "Histone H1.2 OS=Homo sapiens OX=9606 GN=H1-2 PE=1 SV=2" "0.000" "False" "37.524" "26" "6" "23" "1" "213" "21.4" "10.93" "70.84" "6" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3006" "ENSG00000187837" "H1-2" "A8K4I2; hsa:3006; P16403" "" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "2" "0" "1.078" "0.977" "1.062" "0.834" "0.847" "0.949" "1.008" "1.141" "0.737" "543.2" "585.7" "530.8" "577.1" "452.9" "460.1" "515.4" "547.4" "619.7" "400.3" "" "" "" "" "" "" "" "" "" "" "287.6" "324.7" "304.0" "265.8" "245.0" "255.9" "303.4" "298.8" "347.6" "400.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2320605404870657198" "False" "High" "IsMasterProtein" "Q8NC51" "SERPINE1 mRNA-binding protein 1 OS=Homo sapiens OX=9606 GN=SERBP1 PE=1 SV=2" "0.000" "False" "37.505" "22" "7" "10" "7" "408" "44.9" "8.65" "35.06" "7" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf04774, Pf16174" "26135" "ENSG00000142864" "SERBP1" "hsa:26135; Q5VU19; Q5VU20; Q5VU22; Q8NC51; Q8WUH0; Q96SE2; Q9BTY3; Q9BUM4; Q9Y367; Q9Y4S3" "Apoptosis-related network due to altered Notch3 in ovarian cancer" "" "1" "0" "1.179" "1.199" "1.414" "1.351" "1.348" "1.947" "2.158" "1.882" "0.731" "820.8" "967.4" "984.5" "1160.7" "1108.6" "1106.2" "1597.9" "1771.5" "1544.8" "600.1" "" "" "" "" "" "" "" "" "" "" "434.6" "536.3" "563.8" "534.5" "599.8" "615.3" "940.4" "967.0" "866.6" "600.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2595781739747339031" "False" "High" "IsMasterProtein" "Q14677" "Clathrin interactor 1 OS=Homo sapiens OX=9606 GN=CLINT1 PE=1 SV=1" "0.000" "False" "37.453" "16" "9" "13" "9" "625" "68.2" "6.42" "34.80" "9" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01417" "9685" "ENSG00000113282" "CLINT1" "B7Z6F8; D3DQJ6; hsa:9685; Q14677; Q8NAF1; Q96E05" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "1.061" "1.079" "1.111" "1.114" "1.016" "1.186" "1.366" "1.366" "1.086" "1021.9" "1084.0" "1103.0" "1135.8" "1138.8" "1038.7" "1211.8" "1395.7" "1395.6" "1109.7" "" "" "" "" "" "" "" "" "" "" "541.1" "601.0" "631.7" "523.1" "616.2" "577.8" "713.2" "761.8" "782.9" "1109.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6716088986514922399" "False" "High" "IsMasterProtein" "Q13617" "Cullin-2 OS=Homo sapiens OX=9606 GN=CUL2 PE=1 SV=2" "0.000" "False" "37.409" "15" "12" "16" "12" "745" "86.9" "6.92" "40.01" "12" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction" "cytosol;nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8453" "ENSG00000108094" "CUL2" "B3KT95; B7Z6K8; D3DRY6; G3V1S2; hsa:8453; O00200; Q13617; Q5T2B6; Q9UNF9" "Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of expression of SLITs and ROBOs; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation" "6" "0" "0.953" "0.967" "0.936" "0.968" "0.966" "0.969" "0.990" "1.120" "0.628" "1288.2" "1227.7" "1245.5" "1205.8" "1246.7" "1244.0" "1248.0" "1275.5" "1442.8" "808.6" "" "" "" "" "" "" "" "" "" "" "682.1" "680.7" "713.3" "555.3" "674.5" "692.0" "734.5" "696.2" "809.4" "808.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6965600281876429507" "False" "High" "IsMasterProtein" "P46063" "ATP-dependent DNA helicase Q1 OS=Homo sapiens OX=9606 GN=RECQL PE=1 SV=3" "0.000" "False" "37.237" "18" "11" "14" "11" "649" "73.4" "7.88" "38.52" "11" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf16124" "5965" "ENSG00000004700" "RECQL" "A8K6G2; P46063" "Progeria-associated lipodystrophy" "" "1" "0" "0.939" "0.948" "0.956" "0.981" "0.977" "0.937" "0.908" "0.937" "0.645" "2212.6" "2078.1" "2096.6" "2115.8" "2171.4" "2161.3" "2073.6" "2008.3" "2072.8" "1428.0" "" "" "" "" "" "" "" "" "" "" "1171.6" "1152.1" "1200.7" "974.4" "1174.8" "1202.2" "1220.4" "1096.3" "1162.8" "1428.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2320563030437256339" "False" "High" "IsMasterProtein" "Q5RKV6" "Exosome complex component MTR3 OS=Homo sapiens OX=9606 GN=EXOSC6 PE=1 SV=1" "0.000" "False" "37.171" "21" "4" "5" "4" "272" "28.2" "6.28" "22.62" "4" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf01138" "118460" "ENSG00000223496" "EXOSC6" "hsa:118460; Q5RKV6" "" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "6" "0" "0.956" "0.977" "0.828" "0.934" "0.959" "0.898" "1.062" "0.935" "0.370" "751.2" "718.2" "733.6" "621.9" "701.4" "720.0" "674.3" "797.5" "702.3" "277.9" "" "" "" "" "" "" "" "" "" "" "397.7" "398.2" "420.1" "286.4" "379.5" "400.5" "396.8" "435.3" "394.0" "277.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-294736394566280624" "False" "High" "IsMasterProtein" "Q16204" "Coiled-coil domain-containing protein 6 OS=Homo sapiens OX=9606 GN=CCDC6 PE=1 SV=2" "0.000" "False" "37.112" "21" "10" "11" "10" "474" "53.3" "7.34" "31.84" "10" "cell organization and biogenesis" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf09755" "8030" "ENSG00000108091" "CCDC6" "hsa:8030; Q15250; Q16204; Q6GSG7" "Retinoblastoma gene in cancer; Mesodermal commitment pathway; 16p11.2 proximal deletion syndrome" "" "3" "0" "0.990" "1.043" "1.065" "1.038" "1.043" "0.999" "1.039" "1.002" "0.767" "1231.5" "1218.6" "1284.4" "1311.6" "1278.8" "1284.3" "1230.2" "1279.1" "1233.7" "944.9" "" "" "" "" "" "" "" "" "" "" "652.1" "675.6" "735.6" "604.0" "691.9" "714.4" "724.0" "698.2" "692.1" "944.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2458252490920426752" "False" "High" "IsMasterProtein" "P16402" "Histone H1.3 OS=Homo sapiens OX=9606 GN=H1-3 PE=1 SV=2" "0.000" "False" "37.068" "25" "6" "22" "1" "221" "22.3" "11.02" "67.58" "6" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3007" "ENSG00000124575" "H1-3" "B2R751; hsa:3007; P16402; Q2M2I2" "" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "2" "5" "0.983" "1.016" "1.001" "0.950" "0.986" "1.045" "1.083" "1.171" "0.737" "3056.2" "3003.5" "3106.1" "3060.4" "2902.7" "3014.7" "3194.7" "3308.9" "3579.9" "2252.0" "" "" "" "" "" "" "" "" "" "" "1618.3" "1665.2" "1778.9" "1409.4" "1570.4" "1676.9" "1880.2" "1806.2" "2008.2" "2252.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1964393919908826502" "False" "High" "IsMasterProtein" "Q96I99" "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLG2 PE=1 SV=2" "0.000" "False" "37.037" "22" "10" "12" "9" "432" "46.5" "6.39" "30.71" "10" "other metabolic processes" "plasma membrane;other membranes;mitochondrion;other cell component" "other molecular function" "Pf00549, Pf08442" "8801" "ENSG00000172340" "SUCLG2" "C9JVT2; hsa:8801; O95195; Q6NUH7; Q86VX8; Q8WUQ1; Q96I99" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Metabolic reprogramming in colon cancer; TCA cycle (aka Krebs or citric acid cycle)" "Mitochondrial protein degradation; Citric acid cycle (TCA cycle)" "5" "1" "0.958" "0.969" "0.941" "0.946" "0.983" "0.924" "0.826" "0.784" "0.636" "1412.4" "1353.8" "1369.0" "1328.9" "1336.4" "1388.3" "1304.4" "1166.9" "1106.8" "897.9" "" "" "" "" "" "" "" "" "" "" "747.9" "750.6" "784.0" "612.0" "723.0" "772.2" "767.7" "636.9" "620.9" "897.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-917642798524543660" "False" "High" "IsMasterProtein" "P52566" "Rho GDP-dissociation inhibitor 2 OS=Homo sapiens OX=9606 GN=ARHGDIB PE=1 SV=3" "0.000" "False" "36.952" "40" "9" "34" "9" "201" "23.0" "5.21" "86.63" "9" "signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf02115" "397" "ENSG00000111348" "ARHGDIB" "B5BU79; hsa:397; P52566" "Fas ligand pathway and stress induction of heat shock proteins; Vasopressin-regulated water reabsorption; G13 signaling pathway" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC3 GTPase cycle; RHOH GTPase cycle" "9" "0" "0.934" "1.026" "0.922" "0.936" "0.922" "0.862" "0.886" "0.896" "0.832" "3140.7" "2935.0" "3222.1" "2894.5" "2940.3" "2895.5" "2708.8" "2784.0" "2813.1" "2613.9" "" "" "" "" "" "" "" "" "" "" "1663.0" "1627.2" "1845.3" "1333.0" "1590.8" "1610.6" "1594.2" "1519.6" "1578.1" "2613.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5156803787758571728" "False" "High" "IsMasterProtein" "Q14444" "Caprin-1 OS=Homo sapiens OX=9606 GN=CAPRIN1 PE=1 SV=2" "0.000" "False" "36.923" "11" "8" "15" "8" "709" "78.3" "5.25" "47.01" "8" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf12287, Pf18293" "4076" "ENSG00000135387" "CAPRIN1" "A6NMY7; D3DR06; hsa:4076; Q14444; Q15074; Q6IMN4; Q6IMN7; Q9BV09" "" "" "0" "0" "1.041" "1.126" "0.950" "1.005" "1.037" "1.004" "1.156" "1.105" "0.538" "1140.3" "1186.8" "1283.5" "1083.1" "1146.3" "1182.0" "1145.0" "1318.4" "1260.5" "614.0" "" "" "" "" "" "" "" "" "" "" "603.8" "658.0" "735.0" "498.8" "620.2" "657.5" "673.8" "719.7" "707.1" "614.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-504997331308259812" "False" "High" "IsMasterProtein" "P17174" "Aspartate aminotransferase, cytoplasmic OS=Homo sapiens OX=9606 GN=GOT1 PE=1 SV=3" "0.000" "False" "36.919" "24" "9" "16" "9" "413" "46.2" "7.01" "33.77" "9" "other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00155" "2805" "ENSG00000120053" "GOT1" "B2R6R7; B7Z7E9; hsa:2805; P17174; Q5VW80" "Alanine and aspartate metabolism; Trans-sulfuration pathway; Amino acid metabolism; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; TCA cycle in senescence; Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Gluconeogenesis; Aspartate and asparagine metabolism; Methionine salvage pathway" "11" "0" "0.952" "1.005" "0.952" "1.011" "1.030" "1.075" "0.919" "0.963" "0.631" "1176.7" "1119.8" "1182.7" "1119.6" "1189.6" "1212.2" "1265.4" "1081.3" "1132.9" "742.4" "" "" "" "" "" "" "" "" "" "" "623.1" "620.8" "677.3" "515.6" "643.6" "674.3" "744.7" "590.2" "635.5" "742.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3384207672428186398" "False" "High" "IsMasterProtein" "Q8N335" "Glycerol-3-phosphate dehydrogenase 1-like protein OS=Homo sapiens OX=9606 GN=GPD1L PE=1 SV=1" "0.000" "False" "36.917" "21" "8" "16" "8" "351" "38.4" "7.02" "46.46" "8" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01210, Pf07479" "23171" "ENSG00000152642" "GPD1L" "A8K9U3; hsa:23171; Q14702; Q8N335; Q9BRM5" "Sudden infant death syndrome (SIDS) susceptibility pathways" "Synthesis of PA" "2" "0" "1.026" "0.971" "0.969" "1.036" "1.000" "0.901" "0.888" "0.899" "0.889" "2094.6" "2148.4" "2034.1" "2030.4" "2171.0" "2093.9" "1887.1" "1859.2" "1882.4" "1861.9" "" "" "" "" "" "" "" "" "" "" "1109.1" "1191.1" "1165.0" "935.0" "1174.6" "1164.7" "1110.6" "1014.9" "1056.0" "1861.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7824076810458492012" "False" "High" "IsMasterProtein" "P05165" "Propionyl-CoA carboxylase alpha chain, mitochondrial OS=Homo sapiens OX=9606 GN=PCCA PE=1 SV=4" "0.000" "False" "36.871" "15" "11" "12" "11" "728" "80.0" "7.52" "29.01" "11" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00289, Pf00364, Pf02785, Pf02786, Pf18140" "5095" "ENSG00000175198" "PCCA" "B4DKY8; B4DPF9; C9JPQ8; hsa:5095; P05165; Q15979; Q8WXQ7" "Primary ovarian insufficiency" "Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency; Propionyl-CoA catabolism" "4" "0" "0.976" "0.972" "1.014" "1.014" "1.037" "0.986" "0.992" "0.857" "0.591" "1047.4" "1022.3" "1018.0" "1062.2" "1062.3" "1085.6" "1032.8" "1039.3" "897.7" "618.9" "" "" "" "" "" "" "" "" "" "" "554.6" "566.8" "583.0" "489.2" "574.8" "603.9" "607.8" "567.3" "503.6" "618.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5381305641147496779" "False" "High" "IsMasterProtein" "Q9HAV7" "GrpE protein homolog 1, mitochondrial OS=Homo sapiens OX=9606 GN=GRPEL1 PE=1 SV=2" "0.000" "False" "36.863" "47" "10" "18" "10" "217" "24.3" "8.12" "52.26" "10" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf01025" "80273" "ENSG00000109519" "GRPEL1" "B2R783; hsa:80273; Q549M6; Q9HAV7" "" "Mitochondrial protein import" "1" "0" "1.118" "1.158" "0.973" "1.065" "1.106" "1.106" "1.229" "1.291" "0.900" "1827.0" "2041.7" "2114.9" "1777.9" "1945.1" "2020.0" "2020.8" "2246.2" "2358.6" "1644.6" "" "" "" "" "" "" "" "" "" "" "967.4" "1132.0" "1211.2" "818.8" "1052.4" "1123.6" "1189.3" "1226.1" "1323.1" "1644.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6088825967158896660" "False" "High" "IsMasterProtein" "O43290" "U4/U6.U5 tri-snRNP-associated protein 1 OS=Homo sapiens OX=9606 GN=SART1 PE=1 SV=1" "0.000" "False" "36.859" "10" "6" "6" "6" "800" "90.2" "6.13" "22.85" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf03343, Pf19252" "9092" "ENSG00000175467" "SART1" "A6NDN1; hsa:9092; O43290; Q53GB5" "" "mRNA Splicing - Major Pathway" "1" "0" "1.048" "1.072" "1.053" "1.073" "1.057" "1.192" "1.285" "1.304" "0.720" "811.3" "850.5" "869.8" "854.1" "870.3" "857.4" "967.1" "1042.6" "1058.0" "584.5" "" "" "" "" "" "" "" "" "" "" "429.6" "471.5" "498.1" "393.3" "470.8" "476.9" "569.2" "569.1" "593.5" "584.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6179525910857735181" "False" "High" "IsMasterProtein" "P49590" "Histidine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=HARS2 PE=1 SV=1" "0.000" "False" "36.834" "20" "10" "12" "6" "506" "56.9" "8.24" "35.14" "10" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf03129, Pf13393" "23438" "ENSG00000112855" "HARS2" "B4DDY8; hsa:23438; P49590" "Primary ovarian insufficiency" "Mitochondrial tRNA aminoacylation" "2" "0" "0.959" "0.958" "0.969" "1.020" "1.064" "0.923" "0.952" "0.921" "0.557" "774.3" "742.6" "741.6" "750.7" "789.4" "824.2" "714.3" "737.1" "712.8" "431.2" "" "" "" "" "" "" "" "" "" "" "410.0" "411.7" "424.7" "345.7" "427.1" "458.4" "420.4" "402.4" "399.9" "431.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6312780505627043912" "False" "High" "IsMasterProtein" "Q96E39" "RNA binding motif protein, X-linked-like-1 OS=Homo sapiens OX=9606 GN=RBMXL1 PE=1 SV=1" "0.000" "False" "36.733" "28" "12" "18" "2" "390" "42.1" "9.89" "43.41" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf08081" "494115" "ENSG00000213516" "RBMXL1" "hsa:494115; Q96E39" "" "" "0" "0" "0.936" "0.982" "1.627" "1.122" "0.948" "1.051" "1.006" "1.202" "0.767" "28.7" "26.9" "28.2" "46.7" "32.2" "27.2" "30.2" "28.9" "34.5" "22.0" "" "" "" "" "" "" "" "" "" "" "15.2" "14.9" "16.1" "21.5" "17.4" "15.1" "17.8" "15.8" "19.4" "22.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5288684708523747991" "False" "High" "IsMasterProtein" "Q14240" "Eukaryotic initiation factor 4A-II OS=Homo sapiens OX=9606 GN=EIF4A2 PE=1 SV=2" "0.000" "False" "36.703" "22" "8" "18" "4" "407" "46.4" "5.48" "50.46" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1974" "ENSG00000156976" "EIF4A2" "D3DNU9; hsa:1974; Q14240; Q53XJ6; Q96B90; Q96EA8" "Translation factors; Translation inhibitors in chronically activated PDGFRA cells" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; ISG15 antiviral mechanism; Translation initiation complex formation; Ribosomal scanning and start codon recognition; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "11" "0" "0.973" "0.926" "0.924" "1.017" "1.069" "0.982" "0.976" "0.974" "0.708" "918.9" "893.7" "850.8" "848.8" "934.1" "982.4" "902.8" "897.2" "894.8" "650.4" "" "" "" "" "" "" "" "" "" "" "486.6" "495.5" "487.3" "390.9" "505.4" "546.4" "531.3" "489.8" "501.9" "650.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1938619972574952291" "False" "High" "IsMasterProtein" "Q9ULW0" "Targeting protein for Xklp2 OS=Homo sapiens OX=9606 GN=TPX2 PE=1 SV=2" "0.000" "False" "36.662" "11" "9" "11" "9" "747" "85.6" "9.23" "27.61" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf06886, Pf09041, Pf12214" "22974" "ENSG00000088325" "TPX2" "hsa:22974; Q96RR5; Q9H1R4; Q9NRA3; Q9UFN9; Q9UL00; Q9ULW0; Q9Y2M1" "Gastric cancer network 1" "Regulation of TP53 Activity through Phosphorylation; AURKA Activation by TPX2" "3" "0" "1.004" "0.975" "1.002" "0.997" "0.928" "0.933" "0.925" "0.932" "0.595" "1160.2" "1164.8" "1130.7" "1163.1" "1156.8" "1076.3" "1082.8" "1072.9" "1081.8" "690.9" "" "" "" "" "" "" "" "" "" "" "614.3" "645.8" "647.6" "535.6" "625.9" "598.7" "637.3" "585.6" "606.9" "690.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1538896593466497334" "False" "High" "IsMasterProtein" "P23528" "Cofilin-1 OS=Homo sapiens OX=9606 GN=CFL1 PE=1 SV=3" "0.000" "False" "36.658" "40" "7" "36" "6" "166" "18.5" "8.09" "102.55" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00241" "1072" "ENSG00000172757" "CFL1" "B3KUQ1; hsa:1072; P23528; Q53Y87; Q9UCA2" "Brain-derived neurotrophic factor (BDNF) signaling pathway; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; 7q11.23 copy number variation syndrome; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "Platelet degranulation ; Regulation of actin dynamics for phagocytic cup formation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; EPHB-mediated forward signaling; Sema3A PAK dependent Axon repulsion; RHO GTPases Activate ROCKs" "15" "1" "0.941" "1.024" "0.913" "0.914" "0.938" "0.978" "1.062" "1.009" "0.605" "2628.3" "2473.0" "2692.6" "2398.5" "2402.1" "2466.6" "2569.7" "2791.9" "2650.8" "1591.2" "" "" "" "" "" "" "" "" "" "" "1391.7" "1371.1" "1542.0" "1104.6" "1299.6" "1372.0" "1512.3" "1524.0" "1487.0" "1591.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7740854368523393254" "False" "High" "IsMasterProtein" "Q9NR30" "Nucleolar RNA helicase 2 OS=Homo sapiens OX=9606 GN=DDX21 PE=1 SV=5" "0.000" "False" "36.620" "14" "10" "13" "10" "783" "87.3" "9.28" "34.72" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf08152" "9188" "ENSG00000165732" "DDX21" "B2RDL0; hsa:9188; Q13436; Q5VX41; Q68D35; Q9NR30" "10q11.21q11.23 copy number variation syndrome; Rubinstein-Taybi syndrome 1" "B-WICH complex positively regulates rRNA expression; Major pathway of rRNA processing in the nucleolus and cytosol" "4" "0" "0.940" "1.008" "1.280" "1.174" "1.093" "2.056" "1.818" "1.635" "4.168" "453.0" "425.9" "456.6" "579.9" "532.0" "495.1" "931.2" "823.4" "740.7" "1888.0" "" "" "" "" "" "" "" "" "" "" "239.9" "236.1" "261.5" "267.1" "287.8" "275.4" "548.1" "449.5" "415.5" "1888.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3739343134974919134" "False" "High" "IsMasterProtein" "Q92804" "TATA-binding protein-associated factor 2N OS=Homo sapiens OX=9606 GN=TAF15 PE=1 SV=1" "0.000" "False" "36.571" "18" "7" "13" "5" "592" "61.8" "8.02" "38.10" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "8148" "ENSG00000270647; ENSG00000276833" "TAF15" "B2R837; hsa:8148; Q86X94; Q92751; Q92804" "17q12 copy number variation syndrome" "Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "10" "0" "0.961" "1.068" "1.152" "1.238" "1.139" "1.459" "1.613" "1.571" "0.571" "432.1" "415.3" "461.3" "497.8" "535.0" "492.3" "630.3" "696.8" "678.8" "246.7" "" "" "" "" "" "" "" "" "" "" "228.8" "230.3" "264.2" "229.2" "289.5" "273.9" "371.0" "380.4" "380.8" "246.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-453379581051164535" "False" "High" "IsMasterProtein" "P30086" "Phosphatidylethanolamine-binding protein 1 OS=Homo sapiens OX=9606 GN=PEBP1 PE=1 SV=3" "0.000" "False" "36.563" "35" "5" "26" "5" "187" "21.0" "7.53" "76.27" "5" "other biological processes" "cytosol" "enzyme regulator activity;other molecular function" "Pf01161" "5037" "ENSG00000089220" "PEBP1" "B2R4S1; hsa:5037; P30086" "Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants" "9" "0" "1.006" "1.084" "1.046" "1.030" "0.993" "1.000" "1.027" "0.998" "0.563" "1542.5" "1551.3" "1671.4" "1612.7" "1588.3" "1531.1" "1542.2" "1584.1" "1539.9" "868.7" "" "" "" "" "" "" "" "" "" "" "816.7" "860.1" "957.2" "742.7" "859.4" "851.7" "907.7" "864.7" "863.8" "868.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3196973949191465790" "False" "High" "IsMasterProtein" "P07686" "Beta-hexosaminidase subunit beta OS=Homo sapiens OX=9606 GN=HEXB PE=1 SV=4" "0.000" "False" "36.527" "19" "11" "15" "10" "556" "63.1" "6.76" "32.72" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00728, Pf14845" "3074" "ENSG00000049860" "HEXB" "hsa:3074; P07686" "Glycosaminoglycan degradation" "Neutrophil degranulation; CS/DS degradation; Hyaluronan uptake and degradation; Glycosphingolipid catabolism; Keratan sulfate degradation; Defective HEXB causes GM2G2" "7" "1" "1.024" "0.957" "1.010" "1.015" "1.034" "1.041" "0.980" "1.014" "0.727" "1612.8" "1651.2" "1544.0" "1629.0" "1637.7" "1668.4" "1678.6" "1580.5" "1635.5" "1173.2" "" "" "" "" "" "" "" "" "" "" "854.0" "915.5" "884.3" "750.2" "886.0" "928.1" "987.9" "862.7" "917.5" "1173.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5815145421053809259" "False" "High" "IsMasterProtein" "Q16543" "Hsp90 co-chaperone Cdc37 OS=Homo sapiens OX=9606 GN=CDC37 PE=1 SV=1" "0.000" "False" "36.498" "20" "8" "22" "8" "378" "44.4" "5.25" "61.57" "8" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf03234, Pf08564, Pf08565" "11140" "ENSG00000105401" "CDC37" "hsa:11140; Q16543; Q53YA2" "TNF-alpha signaling pathway; Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Interactions between LOXL4 and oxidative stress pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "RHOBTB2 GTPase cycle; Signaling by ERBB2 KD Mutants; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Regulation of necroptotic cell death; Downregulation of ERBB2 signaling; Signaling by ERBB2 TMD/JMD mutants; Constitutive Signaling by Overexpressed ERBB2; Drug-mediated inhibition of ERBB2 signaling; Resistance of ERBB2 KD mutants to trastuzumab; Resistance of ERBB2 KD mutants to sapitinib; Resistance of ERBB2 KD mutants to tesevatinib; Resistance of ERBB2 KD mutants to neratinib; Resistance of ERBB2 KD mutants to osimertinib; Resistance of ERBB2 KD mutants to afatinib; Resistance of ERBB2 KD mutants to AEE788; Resistance of ERBB2 KD mutants to lapatinib; Drug resistance in ERBB2 TMD/JMD mutants" "27" "0" "0.974" "1.033" "0.898" "0.966" "0.948" "0.952" "1.062" "1.023" "0.588" "2591.0" "2523.1" "2677.1" "2325.9" "2501.7" "2455.7" "2467.4" "2752.7" "2649.9" "1522.9" "" "" "" "" "" "" "" "" "" "" "1371.9" "1398.9" "1533.2" "1071.1" "1353.5" "1366.0" "1452.2" "1502.6" "1486.5" "1522.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1734790582977372175" "False" "High" "IsMasterProtein" "P54136" "Arginine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=RARS1 PE=1 SV=2" "0.000" "False" "36.479" "14" "10" "11" "10" "660" "75.3" "6.68" "29.79" "10" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00750, Pf03485, Pf05746" "5917" "ENSG00000113643" "RARS1" "B2RBS9; hsa:5917; P54136; Q53GY4; Q9BWA1" "Amino acid metabolism" "Cytosolic tRNA aminoacylation; Selenoamino acid metabolism" "3" "0" "1.006" "1.002" "1.027" "1.022" "1.086" "0.880" "0.424" "0.903" "6.201" "1031.3" "1037.1" "1032.9" "1059.4" "1053.9" "1120.4" "907.7" "437.0" "930.9" "6395.6" "" "" "" "" "" "" "" "" "" "" "546.1" "575.0" "591.5" "487.9" "570.2" "623.2" "534.2" "238.5" "522.2" "6395.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4157182932771800811" "False" "High" "IsMasterProtein" "Q07955" "Serine/arginine-rich splicing factor 1 OS=Homo sapiens OX=9606 GN=SRSF1 PE=1 SV=2" "0.000" "False" "36.468" "29" "7" "21" "7" "248" "27.7" "10.36" "45.67" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6426" "ENSG00000136450" "SRSF1" "B2R6Z7; D3DTZ3; hsa:6426; Q07955; Q13809" "mRNA processing" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "7" "0" "1.050" "1.125" "0.935" "1.069" "0.977" "0.947" "0.994" "0.945" "0.474" "2176.3" "2285.6" "2448.3" "2035.0" "2325.4" "2126.5" "2060.7" "2163.4" "2057.4" "1030.6" "" "" "" "" "" "" "" "" "" "" "1152.3" "1267.2" "1402.2" "937.2" "1258.1" "1182.9" "1212.8" "1180.9" "1154.2" "1030.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9088967002815659299" "False" "High" "IsMasterProtein" "P26641" "Elongation factor 1-gamma OS=Homo sapiens OX=9606 GN=EEF1G PE=1 SV=3" "0.000" "False" "36.421" "15" "9" "16" "9" "437" "50.1" "6.67" "43.32" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf00043, Pf00647, Pf02798" "1937" "ENSG00000254772" "EEF1G" "B4DTG2; hsa:1937; P26641; Q6PJ62; Q6PK31; Q96CU2; Q9P196" "Translation factors" "Signaling by ALK fusions and activated point mutants; Eukaryotic Translation Elongation" "3" "0" "0.976" "1.067" "1.096" "0.950" "0.987" "0.888" "0.834" "0.998" "2.861" "701.5" "685.0" "748.3" "769.1" "666.5" "692.6" "622.7" "585.3" "700.1" "2007.2" "" "" "" "" "" "" "" "" "" "" "371.5" "379.8" "428.5" "354.2" "360.6" "385.2" "366.5" "319.5" "392.7" "2007.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6056072514061180880" "False" "High" "IsMasterProtein" "Q9Y2D5" "PALM2-AKAP2 fusion protein OS=Homo sapiens OX=9606 GN=PALM2AKAP2 PE=1 SV=4" "0.000" "False" "36.417" "9" "9" "11" "9" "1103" "122.0" "5.06" "34.37" "9" "" "plasma membrane;other membranes" "" "Pf03285, Pf15304" "445815" "ENSG00000157654" "PALM2AKAP2" "A9Z1X9; B1ALX9; B2RTU4; B3KQ00; B4DTZ2; B7ZW07; B9EJB5; hsa:445815; Q8IXS6; Q8N9D5; Q96DU1; Q9UG26; Q9Y2D5" "" "" "0" "0" "1.015" "1.067" "1.159" "1.153" "1.102" "1.322" "1.399" "1.310" "0.739" "1121.7" "1138.3" "1196.4" "1300.5" "1293.1" "1236.3" "1483.2" "1569.5" "1469.9" "829.0" "" "" "" "" "" "" "" "" "" "" "593.9" "631.1" "685.2" "598.9" "699.6" "687.7" "872.9" "856.7" "824.6" "829.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8046944082778510554" "False" "High" "IsMasterProtein" "P32119" "Peroxiredoxin-2 OS=Homo sapiens OX=9606 GN=PRDX2 PE=1 SV=5" "0.000" "False" "36.351" "31" "6" "31" "5" "198" "21.9" "5.97" "91.11" "6" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00578, Pf10417" "7001" "ENSG00000167815" "PRDX2" "A8K0C0; hsa:7001; P31945; P32118; P32119; P35701; Q6FHG4; Q92763; Q9UC23" "Selenium micronutrient network; VEGFA-VEGFR2 signaling; HDAC6 interactions in the central nervous system" "Detoxification of Reactive Oxygen Species; TP53 Regulates Metabolic Genes; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "6" "0" "1.005" "0.965" "0.994" "0.900" "1.022" "0.968" "0.977" "0.931" "0.504" "738.4" "742.1" "712.5" "733.9" "664.3" "754.8" "714.8" "721.2" "687.2" "372.2" "" "" "" "" "" "" "" "" "" "" "391.0" "411.5" "408.1" "338.0" "359.4" "419.8" "420.7" "393.6" "385.5" "372.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8725302829576246174" "False" "High" "IsMasterProtein" "P63151" "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R2A PE=1 SV=1" "0.000" "False" "36.285" "14" "8" "14" "7" "447" "51.7" "6.20" "38.03" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "" "5520" "ENSG00000221914" "PPP2R2A" "B2RBU8; B4E1T7; hsa:5520; P50409; P63151; Q00007" "Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; Initiation of Nuclear Envelope (NE) Reformation" "7" "1" "1.004" "0.974" "0.968" "0.950" "1.058" "1.080" "0.873" "1.009" "0.727" "870.1" "873.8" "847.7" "842.6" "826.6" "920.2" "939.5" "759.6" "877.7" "632.3" "" "" "" "" "" "" "" "" "" "" "460.7" "484.4" "485.5" "388.0" "447.2" "511.9" "552.9" "414.6" "492.4" "632.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-220187434067665020" "False" "High" "IsMasterProtein" "Q6PJT7" "Zinc finger CCCH domain-containing protein 14 OS=Homo sapiens OX=9606 GN=ZC3H14 PE=1 SV=1" "0.000" "False" "36.284" "13" "9" "11" "9" "736" "82.8" "7.31" "28.24" "9" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf14608" "79882" "ENSG00000100722" "ZC3H14" "A8MY46; B4DXU8; B4DZW7; B4E2H4; G3V5R4; hsa:79882; Q6MZU4; Q6PJ32; Q6PJT7; Q6PUI6; Q6PUI8; Q86TQ5; Q86TW0; Q86TW1; Q8NCT6; Q8NCZ3; Q8TDE2; Q9HAC9; Q9Y5A0" "" "" "0" "0" "0.996" "0.989" "1.020" "1.010" "1.031" "1.122" "1.194" "1.156" "0.951" "697.8" "695.2" "689.9" "711.9" "704.8" "719.3" "782.8" "833.4" "806.9" "663.6" "" "" "" "" "" "" "" "" "" "" "369.5" "385.5" "395.1" "327.9" "381.3" "400.1" "460.7" "454.9" "452.6" "663.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "657128700828351651" "False" "High" "IsMasterProtein" "Q16643" "Drebrin OS=Homo sapiens OX=9606 GN=DBN1 PE=1 SV=4" "0.000" "False" "36.254" "15" "8" "10" "8" "649" "71.4" "4.45" "28.31" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "1627" "ENSG00000113758" "DBN1" "A8MV58; B2RBG0; hsa:1627; Q16643; Q9UFZ5" "5q35 copy number variation" "RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle; RHOD GTPase cycle; RHOH GTPase cycle" "5" "0" "0.986" "1.106" "0.896" "0.869" "0.854" "0.913" "0.863" "0.880" "0.589" "351.5" "346.4" "388.9" "314.8" "305.6" "300.4" "320.8" "303.3" "309.4" "207.0" "" "" "" "" "" "" "" "" "" "" "186.1" "192.1" "222.7" "145.0" "165.3" "167.1" "188.8" "165.5" "173.6" "207.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7029277553794243506" "False" "High" "IsMasterProtein" "P61244" "Protein max OS=Homo sapiens OX=9606 GN=MAX PE=1 SV=1" "0.000" "False" "36.231" "44" "7" "10" "7" "160" "18.3" "6.30" "33.93" "7" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "4149" "ENSG00000125952" "MAX" "A6NH73; A8K265; A8K4G4; A8K824; hsa:4149; P25912; P52163; P61244; Q14803; Q96CY8" "B cell receptor signaling pathway; Pathways affected in adenoid cystic carcinoma; MAPK signaling pathway; p38 MAPK signaling pathway; Small cell lung cancer; Pleural mesothelioma; 5q35 copy number variation" "Transcriptional Regulation by E2F6; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry" "11" "0" "0.955" "1.044" "0.874" "1.007" "1.039" "1.161" "0.971" "1.020" "0.568" "495.1" "472.8" "516.6" "432.6" "498.4" "514.4" "574.7" "481.0" "504.9" "281.4" "" "" "" "" "" "" "" "" "" "" "262.1" "262.1" "295.9" "199.2" "269.7" "286.1" "338.2" "262.5" "283.2" "281.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4369524592651400068" "False" "High" "IsMasterProtein" "P43490" "Nicotinamide phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=NAMPT PE=1 SV=1" "0.000" "False" "36.147" "17" "10" "17" "10" "491" "55.5" "7.15" "42.02" "10" "cell-cell signaling;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf04095, Pf18127" "10135" "ENSG00000105835" "NAMPT" "A4D0Q9; A4D0R0; hsa:10135; P43490; Q3KQV0; Q8WW95" "Adipogenesis; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Caloric restriction and aging; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence" "NPAS4 regulates expression of target genes; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Nicotinamide salvaging" "9" "0" "0.971" "0.983" "0.942" "0.995" "1.040" "1.032" "0.993" "1.062" "0.801" "1552.0" "1506.5" "1524.9" "1462.6" "1543.5" "1614.4" "1601.8" "1540.8" "1647.5" "1243.1" "" "" "" "" "" "" "" "" "" "" "821.8" "835.2" "873.3" "673.6" "835.1" "898.0" "942.7" "841.0" "924.2" "1243.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5100342078982033337" "False" "High" "IsMasterProtein" "Q8N684" "Cleavage and polyadenylation specificity factor subunit 7 OS=Homo sapiens OX=9606 GN=CPSF7 PE=1 SV=1" "0.000" "False" "36.130" "16" "8" "11" "8" "471" "52.0" "8.00" "32.98" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "79869" "ENSG00000149532" "CPSF7" "B3KU04; C9K0Q4; hsa:79869; Q7Z3H9; Q8N684; Q9H025; Q9H9V1" "" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; RHOBTB1 GTPase cycle" "5" "0" "1.013" "1.016" "0.990" "1.063" "1.038" "1.111" "1.224" "1.165" "0.667" "1043.4" "1057.0" "1059.6" "1033.2" "1109.3" "1082.6" "1158.8" "1277.2" "1215.1" "695.5" "" "" "" "" "" "" "" "" "" "" "552.5" "586.0" "606.8" "475.8" "600.2" "602.2" "682.0" "697.2" "681.6" "695.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6598258105920115633" "False" "High" "IsMasterProtein" "Q5TDH0" "Protein DDI1 homolog 2 OS=Homo sapiens OX=9606 GN=DDI2 PE=1 SV=1" "0.000" "False" "36.104" "24" "8" "9" "8" "399" "44.5" "5.05" "25.58" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00240, Pf09668" "84301" "ENSG00000197312" "DDI2" "A8KAE1; hsa:84301; Q5TDH0; Q7RTZ0; Q9BRT1" "" "" "0" "0" "1.012" "0.949" "1.066" "1.022" "1.111" "1.058" "1.055" "1.035" "0.866" "468.4" "473.9" "444.7" "499.2" "478.5" "520.6" "495.7" "494.0" "484.6" "405.6" "" "" "" "" "" "" "" "" "" "" "248.0" "262.8" "254.7" "229.9" "258.9" "289.6" "291.7" "269.7" "271.9" "405.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "636638520442762569" "False" "High" "IsMasterProtein" "P54725" "UV excision repair protein RAD23 homolog A OS=Homo sapiens OX=9606 GN=RAD23A PE=1 SV=1" "0.000" "False" "36.065" "24" "8" "18" "6" "363" "39.6" "4.58" "47.19" "8" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00627, Pf09280" "5886" "ENSG00000179262" "RAD23A" "hsa:5886; K7ESE3; P54725; Q59EU8; Q5M7Z1" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Josephin domain DUBs; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "6" "0" "1.068" "1.073" "1.013" "1.068" "0.968" "1.022" "1.065" "0.988" "0.751" "650.6" "695.1" "698.4" "659.3" "694.9" "630.0" "664.8" "693.1" "642.7" "488.5" "" "" "" "" "" "" "" "" "" "" "344.5" "385.4" "400.0" "303.6" "375.9" "350.4" "391.2" "378.3" "360.6" "488.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7338451157516248926" "False" "High" "IsMasterProtein" "Q96IZ0" "PRKC apoptosis WT1 regulator protein OS=Homo sapiens OX=9606 GN=PAWR PE=1 SV=1" "0.000" "False" "36.013" "20" "5" "7" "5" "340" "36.5" "5.41" "25.56" "5" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "5074" "ENSG00000177425" "PAWR" "hsa:5074; O75796; Q6FHY9; Q8N700; Q96IZ0" "" "" "0" "0" "0.953" "1.008" "1.010" "1.024" "0.919" "0.910" "0.911" "0.914" "0.620" "560.6" "534.0" "564.9" "566.1" "574.1" "515.0" "510.0" "510.8" "512.6" "347.4" "" "" "" "" "" "" "" "" "" "" "296.8" "296.1" "323.5" "260.7" "310.6" "286.4" "300.2" "278.8" "287.5" "347.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5272993671693515484" "False" "High" "IsMasterProtein" "Q15181" "Inorganic pyrophosphatase OS=Homo sapiens OX=9606 GN=PPA1 PE=1 SV=2" "0.000" "False" "35.954" "28" "7" "20" "6" "289" "32.6" "5.86" "50.59" "7" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00719" "5464" "ENSG00000180817" "PPA1" "hsa:5464; Q15181; Q2M348; Q5SQT7; Q6P7P4; Q9UQJ5; Q9Y5B1" "" "Cytosolic tRNA aminoacylation; Pyrophosphate hydrolysis" "2" "1" "1.033" "1.109" "1.027" "1.030" "1.088" "1.041" "1.095" "1.079" "0.628" "715.0" "738.5" "793.3" "734.5" "736.3" "778.2" "744.3" "782.7" "771.3" "448.9" "" "" "" "" "" "" "" "" "" "" "378.6" "409.4" "454.3" "338.3" "398.4" "432.9" "438.0" "427.3" "432.7" "448.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "397277040626667291" "False" "High" "IsMasterProtein" "Q9UBB4" "Ataxin-10 OS=Homo sapiens OX=9606 GN=ATXN10 PE=1 SV=1" "0.000" "False" "35.877" "18" "8" "13" "8" "475" "53.5" "5.25" "41.17" "8" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf09759" "25814" "ENSG00000130638" "ATXN10" "A6NLC4; B4DG05; hsa:25814; O14998; O15009; Q6I9X4; Q9UBB4" "Ciliopathies" "" "1" "0" "1.025" "1.029" "1.067" "1.068" "1.013" "1.005" "1.134" "1.082" "0.896" "640.2" "656.4" "658.7" "683.3" "683.5" "648.3" "643.2" "725.7" "692.5" "573.7" "" "" "" "" "" "" "" "" "" "" "339.0" "363.9" "377.2" "314.7" "369.8" "360.6" "378.5" "396.1" "388.5" "573.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3240734639385883819" "False" "High" "IsMasterProtein" "P53004" "Biliverdin reductase A OS=Homo sapiens OX=9606 GN=BLVRA PE=1 SV=2" "0.000" "False" "35.831" "22" "6" "9" "6" "296" "33.4" "6.44" "28.95" "6" "other metabolic processes" "cytosol" "other molecular function" "Pf01408, Pf09166" "644" "ENSG00000106605" "BLVRA" "A8K747; hsa:644; O95019; P53004; Q86UX0; Q96QL4; Q9BRW8" "IL-10 anti-inflammatory signaling pathway" "Cytoprotection by HMOX1; Heme degradation" "3" "0" "1.003" "0.970" "0.983" "1.048" "1.005" "0.954" "0.934" "0.931" "0.837" "852.2" "854.4" "826.4" "838.2" "893.0" "856.3" "813.4" "795.9" "793.3" "713.5" "" "" "" "" "" "" "" "" "" "" "451.3" "473.7" "473.3" "386.0" "483.2" "476.3" "478.7" "434.5" "445.0" "713.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3304952133381549298" "False" "High" "IsMasterProtein" "Q99614" "Tetratricopeptide repeat protein 1 OS=Homo sapiens OX=9606 GN=TTC1 PE=1 SV=1" "0.000" "False" "35.810" "28" "9" "12" "9" "292" "33.5" "4.84" "34.84" "9" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00515, Pf13181" "7265" "ENSG00000113312" "TTC1" "B2RCT2; D3DQJ8; hsa:7265; Q99614; Q9BVT3" "" "" "0" "0" "1.054" "1.078" "0.928" "1.017" "0.992" "0.827" "1.007" "1.021" "0.730" "1011.6" "1065.8" "1091.0" "938.5" "1028.7" "1003.5" "836.6" "1018.3" "1033.3" "738.9" "" "" "" "" "" "" "" "" "" "" "535.7" "590.9" "624.8" "432.2" "556.5" "558.2" "492.4" "555.8" "579.7" "738.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3834517730795482410" "False" "High" "IsMasterProtein" "Q05655" "Protein kinase C delta type OS=Homo sapiens OX=9606 GN=PRKCD PE=1 SV=2" "0.000" "False" "35.799" "16" "10" "11" "10" "676" "77.5" "7.75" "26.71" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00130, Pf00433, Pf21494" "5580" "ENSG00000163932" "PRKCD" "B0KZ81; B2R834; hsa:5580; Q05655; Q15144; Q86XJ6" "Type II diabetes mellitus; Glioblastoma signaling pathways; B cell receptor signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; IL6 signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Wnt signaling pathway and pluripotency; Pancreatic adenocarcinoma pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Hippo signaling regulation pathways; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; IL-18 signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Galanin receptor pathway; Orexin receptor pathway; CCL18 signaling pathway; Chronic hyperglycemia impairment of neuron function; TROP2 regulatory signaling; Calcium regulation in cardiac cells; Type II interferon signaling; T-cell receptor signaling pathway" "CLEC7A (Dectin-1) signaling; KEAP1-NFE2L2 pathway; Neutrophil degranulation; Role of phospholipids in phagocytosis; G alpha (z) signalling events; Interferon gamma signaling; SHC1 events in ERBB2 signaling; HuR (ELAVL1) binds and stabilizes mRNA; VEGFR2 mediated cell proliferation; DAG and IP3 signaling; Effects of PIP2 hydrolysis; RHO GTPases Activate NADPH Oxidases; Calmodulin induced events; Apoptotic cleavage of cellular proteins" "47" "0" "0.983" "0.977" "0.861" "0.973" "1.085" "0.820" "0.849" "0.920" "1.367" "884.8" "869.6" "864.9" "761.7" "860.8" "960.3" "725.1" "750.9" "813.9" "1209.1" "" "" "" "" "" "" "" "" "" "" "468.5" "482.1" "495.3" "350.8" "465.7" "534.2" "426.8" "409.9" "456.6" "1209.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3377056009907556172" "False" "High" "IsMasterProtein" "O14745" "Na(+)/H(+) exchange regulatory cofactor NHE-RF1 OS=Homo sapiens OX=9606 GN=NHERF1 PE=1 SV=4" "0.000" "False" "35.734" "25" "9" "16" "9" "358" "38.8" "5.77" "44.15" "9" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "signal transduction activity or receptor binding;transporter activity;cytoskeletal activity;other molecular function" "Pf00595, Pf09007" "9368" "ENSG00000109062" "NHERF1" "B3KY21; hsa:9368; O14745; O43552; Q86WQ5" "TAR syndrome" "" "1" "0" "0.985" "1.019" "0.993" "1.015" "0.932" "1.033" "1.163" "1.099" "0.487" "1279.8" "1260.2" "1304.3" "1271.0" "1298.6" "1192.5" "1321.5" "1489.0" "1406.3" "622.8" "" "" "" "" "" "" "" "" "" "" "677.7" "698.7" "747.0" "585.3" "702.6" "663.3" "777.7" "812.8" "788.9" "622.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7405730642826192701" "False" "High" "IsMasterProtein" "P00390" "Glutathione reductase, mitochondrial OS=Homo sapiens OX=9606 GN=GSR PE=1 SV=2" "0.000" "False" "35.733" "16" "9" "14" "9" "522" "56.2" "8.50" "38.74" "9" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion" "other molecular function" "Pf00070, Pf02852" "2936" "ENSG00000104687" "GSR" "C8KIL8; C8KIL9; C8KIM0; D3DSV3; hsa:2936; P00390; Q7Z5C9; Q9NP63" "Glutathione metabolism; Selenium micronutrient network; Trans-sulfuration, one-carbon metabolism and related pathways; Nuclear receptors meta-pathway; NRF2 pathway; Amino acid metabolism; One-carbon metabolism and related pathways; Oxidative stress response; Vitamin D-sensitive calcium signaling in depression; Sulfation biotransformation reaction; Metapathway biotransformation Phase I and II" "" "11" "0" "0.986" "0.947" "0.972" "1.003" "0.986" "1.160" "0.983" "0.948" "0.600" "861.4" "849.1" "815.7" "837.6" "863.6" "849.0" "998.8" "847.0" "817.0" "517.0" "" "" "" "" "" "" "" "" "" "" "456.1" "470.8" "467.1" "385.7" "467.2" "472.2" "587.8" "462.4" "458.3" "517.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7002487047349753336" "False" "High" "IsMasterProtein" "P22392" "Nucleoside diphosphate kinase B OS=Homo sapiens OX=9606 GN=NME2 PE=1 SV=1" "0.000" "False" "35.659" "54" "8" "42" "4" "152" "17.3" "8.41" "118.42" "8" "cell adhesion;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00334" "4831; 654364" "ENSG00000243678" "NME2" "A8MWA3; hsa:4831; hsa:654364; P22392; Q1WM23; Q6LCT6" "Pyrimidine metabolism" "Azathioprine ADME; Neutrophil degranulation; Interconversion of nucleotide di- and triphosphates; Ribavirin ADME" "5" "4" "0.957" "0.960" "0.931" "0.951" "1.014" "1.009" "0.986" "0.944" "0.575" "3324.9" "3181.8" "3192.7" "3094.8" "3163.7" "3370.4" "3354.0" "3276.9" "3137.6" "1911.2" "" "" "" "" "" "" "" "" "" "" "1760.5" "1764.1" "1828.5" "1425.2" "1711.7" "1874.8" "1973.9" "1788.7" "1760.1" "1911.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6973941838255417452" "False" "High" "IsMasterProtein" "P56192" "Methionine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=MARS1 PE=1 SV=2" "0.000" "False" "35.651" "11" "9" "12" "9" "900" "101.1" "6.16" "38.15" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00043, Pf00458, Pf09334, Pf18485, Pf19303" "4141" "ENSG00000166986" "MARS1" "B3KVK7; hsa:4141; P56192; Q14895; Q53H14; Q96A15; Q96BZ0; Q9NSE0" "" "Cytosolic tRNA aminoacylation; Selenoamino acid metabolism" "2" "0" "1.043" "0.915" "1.107" "1.122" "1.097" "0.908" "0.496" "0.893" "5.159" "778.9" "812.7" "713.1" "862.0" "874.0" "854.6" "707.3" "386.2" "695.7" "4018.6" "" "" "" "" "" "" "" "" "" "" "412.4" "450.6" "408.4" "397.0" "472.9" "475.3" "416.3" "210.8" "390.3" "4018.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6465314109903613014" "False" "High" "IsMasterProtein" "Q99615" "DnaJ homolog subfamily C member 7 OS=Homo sapiens OX=9606 GN=DNAJC7 PE=1 SV=2" "0.000" "False" "35.508" "21" "12" "14" "12" "494" "56.4" "6.96" "36.67" "12" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00226" "7266" "ENSG00000168259" "DNAJC7" "hsa:7266; Q7Z784; Q99615" "Constitutive androstane receptor pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway" "Regulation of HSF1-mediated heat shock response" "4" "0" "1.081" "1.193" "1.216" "1.038" "1.090" "0.962" "0.618" "0.962" "5.646" "672.4" "726.7" "802.4" "817.5" "698.1" "733.2" "647.2" "415.4" "646.6" "3796.6" "" "" "" "" "" "" "" "" "" "" "356.1" "402.9" "459.5" "376.5" "377.7" "407.8" "380.9" "226.8" "362.7" "3796.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4968571585111953171" "False" "High" "IsMasterProtein" "P55036" "26S proteasome non-ATPase regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PSMD4 PE=1 SV=1" "0.000" "False" "35.501" "19" "6" "15" "6" "377" "40.7" "4.79" "37.44" "6" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02809, Pf13519" "5710" "ENSG00000159352" "PSMD4" "D3DV16; hsa:5710; P55036; Q5VWC5; Q9NS92" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "1.169" "1.048" "1.170" "1.095" "1.072" "1.041" "1.024" "0.974" "0.638" "1149.6" "1343.5" "1204.7" "1345.3" "1259.2" "1231.9" "1196.8" "1177.0" "1120.2" "733.3" "" "" "" "" "" "" "" "" "" "" "608.7" "744.9" "689.9" "619.6" "681.3" "685.2" "704.4" "642.5" "628.4" "733.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2591250137459754120" "False" "High" "IsMasterProtein" "O43252" "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 OS=Homo sapiens OX=9606 GN=PAPSS1 PE=1 SV=2" "0.000" "False" "35.491" "15" "10" "12" "10" "624" "70.8" "6.86" "34.72" "10" "other metabolic processes;developmental processes" "cytosol" "kinase activity;other molecular function" "Pf01583, Pf01747, Pf14306" "9061" "ENSG00000138801" "PAPSS1" "hsa:9061; O43252; O43841; O75332; Q6IAX6; Q96FB1; Q96TF4; Q9P1P9; Q9UE98" "Sulfation biotransformation reaction" "Signaling by BRAF and RAF1 fusions; Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se" "4" "0" "1.017" "0.977" "0.948" "0.965" "0.998" "0.906" "0.960" "0.944" "0.534" "1272.7" "1293.7" "1243.2" "1206.2" "1227.6" "1269.8" "1153.3" "1221.4" "1201.2" "680.1" "" "" "" "" "" "" "" "" "" "" "673.9" "717.3" "712.0" "555.5" "664.2" "706.3" "678.7" "666.7" "673.9" "680.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7752798674986433827" "False" "High" "IsMasterProtein" "Q5T4S7" "E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens OX=9606 GN=UBR4 PE=1 SV=1" "0.000" "False" "35.486" "2" "10" "11" "10" "5183" "573.5" "6.04" "24.05" "10" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf02207, Pf13764, Pf19423" "23352" "ENSG00000127481" "UBR4" "A8MPT2; A8MQ33; A8MQB1; O60646; O75050; Q4QRK5; Q5T4S7; Q5T4S8; Q5T4S9; Q5TBN8; Q5TBP2; Q6DKH8; Q6P4A4; Q7L8P7; Q8IXJ4; Q8TDN5; Q8WV67; Q9HA46; Q9P2N9; Q9UG82" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neutrophil degranulation" "2" "0" "0.995" "0.982" "1.008" "1.013" "1.025" "0.949" "0.867" "0.899" "2.646" "488.5" "485.8" "479.5" "492.4" "494.7" "500.9" "463.5" "423.5" "439.3" "1292.5" "" "" "" "" "" "" "" "" "" "" "258.6" "269.3" "274.6" "226.8" "267.6" "278.6" "272.8" "231.2" "246.4" "1292.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3873794915793825420" "False" "High" "IsMasterProtein" "Q9BYT8" "Neurolysin, mitochondrial OS=Homo sapiens OX=9606 GN=NLN PE=1 SV=1" "0.000" "False" "35.469" "14" "10" "16" "10" "704" "80.6" "6.64" "38.34" "10" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion" "other molecular function" "Pf01432" "57486" "ENSG00000123213" "NLN" "hsa:57486; Q9BYT8; Q9ULJ4" "" "Peptide ligand-binding receptors" "1" "0" "0.973" "0.967" "0.970" "0.974" "1.022" "0.917" "1.031" "0.919" "0.597" "1499.1" "1458.3" "1450.0" "1454.6" "1460.3" "1531.4" "1375.3" "1545.8" "1378.1" "895.4" "" "" "" "" "" "" "" "" "" "" "793.8" "808.5" "830.4" "669.9" "790.1" "851.8" "809.4" "843.8" "773.1" "895.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6184402302268645522" "False" "High" "IsMasterProtein" "Q5JRX3" "Presequence protease, mitochondrial OS=Homo sapiens OX=9606 GN=PITRM1 PE=1 SV=3" "0.000" "False" "35.409" "11" "10" "13" "10" "1037" "117.3" "6.92" "32.93" "10" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "enzyme regulator activity;other molecular function" "Pf00675, Pf05193, Pf08367" "10531" "ENSG00000107959" "PITRM1" "B3KMJ6; B4E0J8; C9JSL2; E7ES23; hsa:10531; O95204; Q2M2G6; Q4VBR1; Q5JRW7; Q5JRX3; Q7L5Z7; Q9BSI6; Q9BVJ5; Q9UPP8" "" "Mitochondrial protein import" "1" "0" "0.989" "1.019" "1.105" "1.057" "1.096" "1.087" "1.078" "1.045" "1.067" "1251.5" "1237.3" "1275.7" "1383.2" "1322.2" "1371.0" "1360.2" "1349.4" "1307.2" "1335.2" "" "" "" "" "" "" "" "" "" "" "662.7" "686.0" "730.6" "637.0" "715.4" "762.6" "800.5" "736.6" "733.3" "1335.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5829960447854698720" "False" "High" "IsMasterProtein" "O43399" "Tumor protein D54 OS=Homo sapiens OX=9606 GN=TPD52L2 PE=1 SV=2" "0.000" "False" "35.206" "37" "6" "15" "6" "206" "22.2" "5.36" "48.94" "6" "other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf04201" "7165" "ENSG00000101150" "TPD52L2" "B4DPJ6; E1P5G7; hsa:7165; O43398; O43399; Q5JWU5; Q5JWU6; Q5JWU8; Q5U0E0; Q9H3Z6" "" "" "0" "0" "1.195" "1.247" "1.187" "1.165" "1.134" "1.174" "1.332" "1.275" "0.801" "713.3" "852.0" "889.4" "846.5" "830.8" "809.1" "837.3" "950.3" "909.2" "571.2" "" "" "" "" "" "" "" "" "" "" "377.7" "472.4" "509.3" "389.8" "449.5" "450.0" "492.7" "518.7" "510.0" "571.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5359713146649655482" "False" "High" "IsMasterProtein" "P31150" "Rab GDP dissociation inhibitor alpha OS=Homo sapiens OX=9606 GN=GDI1 PE=1 SV=2" "0.000" "False" "35.097" "25" "9" "12" "5" "447" "50.6" "5.14" "30.05" "9" "cell organization and biogenesis;transport;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "2664" "ENSG00000203879" "GDI1" "hsa:2664; P31150; P50394; Q6FG50; Q7Z2G6; Q7Z2G9; Q7Z2H5; Q7Z2I6" "Ciliary landscape; Airway smooth muscle cell contraction" "RAB GEFs exchange GTP for GDP on RABs" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3895528791649615838" "False" "High" "IsMasterProtein" "Q86UE4" "Protein LYRIC OS=Homo sapiens OX=9606 GN=MTDH PE=1 SV=2" "0.000" "False" "35.071" "13" "7" "10" "7" "582" "63.8" "9.32" "32.17" "7" "signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15686" "92140" "ENSG00000147649" "MTDH" "hsa:92140; Q05DH2; Q52QU9; Q6PK07; Q86UE4; Q8TCX3" "Gastric cancer network 2; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; CCL18 signaling pathway" "" "3" "0" "1.000" "1.000" "1.127" "1.114" "1.023" "1.307" "1.451" "1.313" "0.529" "1035.3" "1035.1" "1035.7" "1167.0" "1153.6" "1059.2" "1352.7" "1502.0" "1359.6" "547.3" "" "" "" "" "" "" "" "" "" "" "548.2" "573.9" "593.2" "537.4" "624.2" "589.2" "796.1" "819.9" "762.7" "547.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6821815504623325969" "False" "High" "IsMasterProtein" "Q9UMX0" "Ubiquilin-1 OS=Homo sapiens OX=9606 GN=UBQLN1 PE=1 SV=2" "0.000" "False" "35.009" "13" "6" "12" "2" "589" "62.5" "5.11" "38.93" "6" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf00627" "29979" "ENSG00000135018" "UBQLN1" "A0A024R284; hsa:29979; Q5T6J5; Q5T6J9; Q8IXS9; Q8N2Q3; Q9H0T8; Q9H3R4; Q9HAZ5; Q9UMX0" "" "Cargo recognition for clathrin-mediated endocytosis" "1" "0" "0.984" "0.994" "0.965" "0.967" "0.947" "1.045" "0.974" "1.095" "0.639" "244.3" "240.4" "242.8" "235.8" "236.2" "231.2" "255.3" "238.0" "267.6" "156.0" "" "" "" "" "" "" "" "" "" "" "129.3" "133.3" "139.1" "108.6" "127.8" "128.6" "150.3" "129.9" "150.1" "156.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6101173507286650100" "False" "High" "IsMasterProtein" "O43852" "Calumenin OS=Homo sapiens OX=9606 GN=CALU PE=1 SV=2" "0.000" "False" "34.910" "29" "8" "12" "8" "315" "37.1" "4.64" "30.02" "8" "" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf13202" "813" "ENSG00000128595" "CALU" "B3KPG9; D6QS48; D6QS49; D6QS50; D6QS51; D6QS52; D6QS53; D6QS54; D6QS55; D6QS56; D6QS57; D6QS58; D6QS59; F5H1Q9; F5H879; hsa:813; O43852; O60456; Q6FHB9; Q96RL3; Q9NR43" "NOTCH1 regulation of endothelial cell calcification; VEGFA-VEGFR2 signaling" "Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "5" "0" "1.025" "1.063" "1.085" "1.060" "0.981" "1.003" "1.060" "0.972" "0.751" "1398.8" "1434.3" "1486.4" "1517.8" "1483.2" "1371.6" "1403.0" "1483.3" "1359.1" "1051.2" "" "" "" "" "" "" "" "" "" "" "740.7" "795.2" "851.3" "699.0" "802.5" "763.0" "825.7" "809.7" "762.4" "1051.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5905184492137342602" "False" "High" "IsMasterProtein" "P08559" "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial OS=Homo sapiens OX=9606 GN=PDHA1 PE=1 SV=3" "0.000" "False" "34.879" "18" "7" "16" "7" "390" "43.3" "8.06" "37.91" "7" "other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00676" "5160" "ENSG00000131828" "PDHA1" "A5YVE9; B2R5P7; B7Z3T7; B7Z3X5; hsa:5160; P08559; Q53H41; Q5JPT8; Q9NP12; Q9UBJ8; Q9UBU0; Q9UNG4; Q9UNG5" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Lipid metabolism pathway; PI3K/AKT/mTOR - vitamin D3 signaling; Hereditary leiomyomatosis and renal cell carcinoma pathway; Metabolic reprogramming in colon cancer; Thiamine metabolic pathways; TCA cycle in senescence; Neuroinflammation and glutamatergic signaling; Acetylcholine synthesis; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Mitochondrial protein degradation" "17" "0" "1.037" "0.986" "0.951" "0.926" "0.963" "0.844" "0.845" "0.809" "0.656" "1557.7" "1614.6" "1536.0" "1481.7" "1442.3" "1500.6" "1315.1" "1315.9" "1260.1" "1022.6" "" "" "" "" "" "" "" "" "" "" "824.8" "895.2" "879.6" "682.4" "780.3" "834.7" "774.0" "718.3" "706.9" "1022.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8781846477469752128" "False" "High" "IsMasterProtein" "P38606" "V-type proton ATPase catalytic subunit A OS=Homo sapiens OX=9606 GN=ATP6V1A PE=1 SV=2" "0.000" "False" "34.818" "16" "9" "11" "9" "617" "68.3" "5.52" "33.36" "9" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00006, Pf02874, Pf16886" "523" "ENSG00000114573" "ATP6V1A" "B2RBR8; B7Z1R5; D3DN75; hsa:523; P38606; Q53YD9; Q96DY6; Q9UHY3" "Proximal tubule transport" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "6" "0" "1.001" "0.972" "0.974" "0.971" "1.042" "0.964" "0.998" "0.947" "0.856" "871.8" "872.2" "847.0" "849.2" "846.1" "908.7" "840.7" "870.2" "825.3" "746.5" "" "" "" "" "" "" "" "" "" "" "461.6" "483.6" "485.1" "391.1" "457.8" "505.4" "494.8" "475.0" "463.0" "746.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3295496481374294049" "False" "High" "IsMasterProtein" "Q9UHD9" "Ubiquilin-2 OS=Homo sapiens OX=9606 GN=UBQLN2 PE=1 SV=2" "0.000" "False" "34.782" "13" "6" "12" "2" "624" "65.7" "5.22" "39.01" "6" "cell organization and biogenesis;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf00627" "29978" "ENSG00000188021" "UBQLN2" "hsa:29978; O94798; Q5D027; Q9H3W6; Q9HAZ4; Q9UHD9" "" "Cargo recognition for clathrin-mediated endocytosis" "1" "4" "1.022" "1.051" "0.928" "1.021" "1.089" "1.028" "1.060" "1.056" "0.856" "782.1" "799.1" "821.7" "726.1" "798.2" "851.9" "803.9" "829.2" "825.6" "669.7" "" "" "" "" "" "" "" "" "" "" "414.1" "443.1" "470.6" "334.4" "431.9" "473.9" "473.1" "452.6" "463.2" "669.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9189590484777075943" "False" "High" "IsMasterProtein" "Q13185" "Chromobox protein homolog 3 OS=Homo sapiens OX=9606 GN=CBX3 PE=1 SV=4" "0.000" "False" "34.764" "32" "5" "12" "4" "183" "20.8" "5.33" "34.69" "5" "cell organization and biogenesis;stress response;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00385, Pf01393" "11335" "ENSG00000122565" "CBX3" "hsa:11335; Q13185; Q96CD7; Q99409; Q9BVS3; Q9P0Z6" "Exercise-induced circadian regulation; Effect of progerin on genes involved in progeria; NIPBL role in DNA damage - Cornelia de Lange syndrome" "Transcriptional Regulation by E2F6; RNA Polymerase I Promoter Escape; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" "6" "0" "0.889" "1.011" "0.917" "0.964" "0.871" "0.897" "0.931" "0.991" "1.028" "1357.6" "1206.2" "1372.7" "1244.9" "1309.3" "1182.7" "1217.9" "1264.1" "1345.0" "1395.4" "" "" "" "" "" "" "" "" "" "" "718.8" "668.8" "786.1" "573.3" "708.4" "657.9" "716.8" "690.0" "754.5" "1395.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6898362588139573585" "False" "High" "IsMasterProtein" "Q01105" "Protein SET OS=Homo sapiens OX=9606 GN=SET PE=1 SV=3" "0.000" "False" "34.760" "23" "6" "16" "6" "290" "33.5" "4.32" "47.95" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00956" "6418" "ENSG00000119335" "SET" "A5A5H4; A6NGV1; B4DUE2; hsa:6418; Q01105; Q15541; Q5VXV1; Q5VXV2; Q6FHZ5" "Histone modifications; VEGFA-VEGFR2 signaling" "HuR (ELAVL1) binds and stabilizes mRNA; Condensation of Prophase Chromosomes" "4" "0" "0.972" "1.112" "1.024" "0.953" "0.882" "0.881" "0.936" "0.943" "0.727" "1235.2" "1200.2" "1374.1" "1265.0" "1177.3" "1089.2" "1088.1" "1155.8" "1165.0" "897.9" "" "" "" "" "" "" "" "" "" "" "654.0" "665.4" "787.0" "582.6" "637.0" "605.8" "640.4" "630.9" "653.6" "897.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4844416647535235754" "False" "High" "IsMasterProtein" "O00233" "26S proteasome non-ATPase regulatory subunit 9 OS=Homo sapiens OX=9606 GN=PSMD9 PE=1 SV=3" "0.000" "False" "34.758" "35" "7" "13" "7" "223" "24.7" "6.95" "33.31" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf17820, Pf18265" "5715" "ENSG00000110801" "PSMD9" "B2RD35; G3V1Q6; hsa:5715; O00233; Q9BQ42" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "0.983" "1.017" "0.988" "1.057" "0.941" "0.971" "0.980" "0.927" "0.810" "714.0" "702.0" "725.8" "705.7" "754.7" "672.0" "693.4" "699.4" "661.7" "578.3" "" "" "" "" "" "" "" "" "" "" "378.1" "389.2" "415.7" "325.0" "408.3" "373.8" "408.1" "381.8" "371.2" "578.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5857660237806613264" "False" "High" "IsMasterProtein" "Q9NXV6" "CDKN2A-interacting protein OS=Homo sapiens OX=9606 GN=CDKN2AIP PE=1 SV=3" "0.000" "False" "34.751" "17" "8" "10" "8" "580" "61.1" "9.01" "25.08" "8" "stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf11952" "55602" "ENSG00000168564" "CDKN2AIP" "hsa:55602; Q8TBM5; Q9NXV6; Q9NYH0" "" "" "0" "0" "0.975" "1.016" "0.993" "1.030" "1.066" "1.033" "1.055" "1.058" "1.079" "743.1" "724.5" "754.9" "737.7" "765.4" "792.0" "767.5" "783.7" "786.0" "802.1" "" "" "" "" "" "" "" "" "" "" "393.5" "401.7" "432.3" "339.7" "414.1" "440.5" "451.7" "427.8" "440.9" "802.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1822360151641721881" "False" "High" "IsMasterProtein" "Q9NP81" "Serine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=SARS2 PE=1 SV=1" "0.000" "False" "34.666" "17" "8" "8" "8" "518" "58.2" "8.13" "21.89" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00587" "54938" "ENSG00000104835; ENSG00000283104" "SARS2" "A6NHW7; B4DE10; hsa:54938; Q9BVP3; Q9NP81" "Selenium metabolism and selenoproteins" "Mitochondrial tRNA aminoacylation" "2" "0" "1.028" "1.103" "1.099" "1.167" "1.169" "0.987" "0.966" "0.994" "0.785" "726.3" "746.4" "801.2" "798.2" "847.7" "849.2" "717.0" "701.8" "721.6" "570.2" "" "" "" "" "" "" "" "" "" "" "384.6" "413.8" "458.8" "367.6" "458.6" "472.3" "422.0" "383.1" "404.8" "570.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2179215368678635356" "False" "High" "IsMasterProtein" "Q8IYB8" "ATP-dependent RNA helicase SUPV3L1, mitochondrial OS=Homo sapiens OX=9606 GN=SUPV3L1 PE=1 SV=1" "0.000" "False" "34.653" "11" "8" "10" "8" "786" "87.9" "7.99" "25.15" "8" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf00271, Pf12513, Pf18114, Pf18147" "6832" "ENSG00000156502" "SUPV3L1" "A8K301; hsa:6832; O43630; Q8IYB8" "" "Mitochondrial RNA degradation" "1" "0" "1.115" "1.157" "1.240" "1.135" "1.138" "1.112" "1.064" "1.052" "0.978" "553.5" "617.3" "640.4" "686.3" "628.4" "629.9" "615.2" "589.1" "582.1" "541.1" "" "" "" "" "" "" "" "" "" "" "293.1" "342.2" "366.7" "316.0" "340.0" "350.4" "362.1" "321.6" "326.6" "541.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2641060010654775307" "False" "High" "IsMasterProtein" "O00232" "26S proteasome non-ATPase regulatory subunit 12 OS=Homo sapiens OX=9606 GN=PSMD12 PE=1 SV=3" "0.000" "False" "34.645" "23" "10" "18" "10" "456" "52.9" "7.65" "30.01" "10" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf01399, Pf18098" "5718" "ENSG00000197170" "PSMD12" "A6NP15; hsa:5718; O00232; Q53HA2; Q6P053" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "65" "0" "0.950" "0.916" "0.989" "0.956" "0.974" "0.930" "0.829" "0.841" "0.713" "729.1" "692.8" "668.3" "721.3" "697.4" "710.5" "677.9" "604.5" "613.2" "519.6" "" "" "" "" "" "" "" "" "" "" "386.1" "384.1" "382.7" "332.2" "377.3" "395.2" "398.9" "330.0" "344.0" "519.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7978508680545557598" "False" "High" "IsMasterProtein" "Q1KMD3" "Heterogeneous nuclear ribonucleoprotein U-like protein 2 OS=Homo sapiens OX=9606 GN=HNRNPUL2 PE=1 SV=1" "0.000" "False" "34.562" "15" "11" "16" "11" "747" "85.1" "4.91" "43.03" "11" "" "nucleus;other cell component" "" "Pf00622, Pf02037, Pf13671" "221092" "ENSG00000214753" "HNRNPUL2" "hsa:221092; Q1KMD3; Q8N3B3" "" "" "0" "0" "0.972" "1.031" "0.934" "1.022" "1.031" "0.787" "0.781" "0.932" "2.504" "955.0" "928.6" "984.5" "891.7" "976.4" "985.0" "752.0" "746.0" "890.2" "2391.2" "" "" "" "" "" "" "" "" "" "" "505.7" "514.8" "563.8" "410.7" "528.3" "547.9" "442.6" "407.2" "499.4" "2391.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4709536422529614216" "False" "High" "IsMasterProtein" "P20618" "Proteasome subunit beta type-1 OS=Homo sapiens OX=9606 GN=PSMB1 PE=1 SV=2" "0.000" "False" "34.527" "32" "6" "16" "6" "241" "26.5" "8.13" "50.98" "6" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00227" "5689" "ENSG00000008018" "PSMB1" "B5BU76; hsa:5689; P20618; Q9BWA8" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Neutrophil degranulation" "63" "0" "0.881" "0.926" "0.829" "0.968" "0.949" "0.930" "0.867" "0.877" "0.674" "911.3" "802.8" "844.3" "755.3" "881.9" "864.6" "847.1" "790.2" "799.2" "614.3" "" "" "" "" "" "" "" "" "" "" "482.5" "445.1" "483.5" "347.9" "477.1" "480.9" "498.5" "431.3" "448.3" "614.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "289825156273590713" "False" "High" "IsMasterProtein" "Q5JTV8" "Torsin-1A-interacting protein 1 OS=Homo sapiens OX=9606 GN=TOR1AIP1 PE=1 SV=2" "0.000" "False" "34.483" "12" "6" "11" "6" "583" "66.2" "8.18" "36.91" "6" "cell organization and biogenesis;other biological processes" "other membranes;nucleus" "cytoskeletal activity;other molecular function" "Pf05609, Pf20443" "26092" "ENSG00000143337" "TOR1AIP1" "A0A0A0MSK5; A8K630; B0QZ57; hsa:26092; Q5JTV6; Q5JTV8; Q8IZ65; Q9H8Y6; Q9HAJ1; Q9NV52; Q9Y3X5" "Influence of laminopathies on Wnt signaling" "RHOD GTPase cycle; RHOF GTPase cycle" "3" "0" "1.009" "1.037" "1.113" "1.070" "1.045" "1.057" "1.091" "0.999" "0.553" "870.2" "877.7" "902.7" "968.8" "930.8" "909.1" "920.1" "949.2" "869.7" "481.5" "" "" "" "" "" "" "" "" "" "" "460.7" "486.6" "517.0" "446.2" "503.6" "505.7" "541.5" "518.1" "487.9" "481.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4642176776796334220" "False" "High" "IsMasterProtein" "P35580" "Myosin-10 OS=Homo sapiens OX=9606 GN=MYH10 PE=1 SV=3" "0.000" "False" "34.462" "5" "10" "16" "2" "1976" "228.9" "5.54" "47.01" "10" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00063, Pf00612, Pf01576, Pf02736" "4628" "ENSG00000133026" "MYH10" "B2RWP9; D3DTS1; F8VTL3; hsa:4628; P35580; Q12989; Q149N3; Q149N4; Q16087; Q4LE45; Q6PK16; Q9BWG0" "Regulation of actin cytoskeleton" "EPHA-mediated growth cone collapse; RHO GTPases activate PAKs; RHO GTPases activate CIT; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5413684009215812555" "False" "High" "IsMasterProtein" "O15143" "Actin-related protein 2/3 complex subunit 1B OS=Homo sapiens OX=9606 GN=ARPC1B PE=1 SV=3" "0.000" "False" "34.461" "16" "6" "12" "6" "372" "40.9" "8.35" "42.59" "6" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400" "10095" "ENSG00000130429" "ARPC1B" "hsa:10095; O15143; Q9BU00" "Pathogenic Escherichia coli infection; Microglia pathogen phagocytosis pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling" "6" "0" "0.924" "1.079" "0.924" "0.942" "0.938" "0.898" "0.910" "0.888" "0.554" "2250.6" "2080.5" "2427.4" "2079.6" "2120.2" "2110.3" "2020.0" "2048.0" "1998.5" "1247.0" "" "" "" "" "" "" "" "" "" "" "1191.7" "1153.5" "1390.2" "957.7" "1147.1" "1173.8" "1188.8" "1117.9" "1121.1" "1247.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2531564844693564972" "False" "High" "IsMasterProtein" "O75475" "PC4 and SFRS1-interacting protein OS=Homo sapiens OX=9606 GN=PSIP1 PE=1 SV=1" "0.000" "False" "34.337" "22" "13" "20" "12" "530" "60.1" "9.13" "41.86" "13" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00855, Pf11467" "11168" "ENSG00000164985" "PSIP1" "D3DRI9; hsa:11168; O00256; O75475; O95368; Q6P391; Q86YB9; Q9NZI3; Q9UER6" "MECP2 and associated Rett syndrome" "Vpr-mediated nuclear import of PICs; Formation of WDR5-containing histone-modifying complexes; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection" "8" "0" "0.986" "1.004" "1.092" "0.980" "0.937" "0.888" "0.921" "0.902" "0.850" "1647.7" "1625.3" "1654.4" "1799.6" "1614.5" "1543.1" "1463.3" "1518.0" "1485.4" "1400.5" "" "" "" "" "" "" "" "" "" "" "872.4" "901.1" "947.5" "828.8" "873.5" "858.3" "861.2" "828.6" "833.3" "1400.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2034922387344060046" "False" "High" "IsMasterProtein" "P12955" "Xaa-Pro dipeptidase OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=3" "0.000" "False" "34.280" "15" "7" "9" "7" "493" "54.5" "6.00" "28.28" "7" "protein metabolism;other metabolic processes;other biological processes" "" "other molecular function" "Pf00557, Pf05195" "5184" "ENSG00000124299" "PEPD" "A8K3Z1; A8K416; A8K696; A8MX47; B4DDB7; B4DGJ1; E9PCE8; hsa:5184; P12955; Q8TBN9; Q9BT75" "" "" "0" "0" "0.957" "0.917" "0.954" "0.976" "0.952" "1.132" "0.913" "0.878" "0.568" "879.9" "841.8" "806.8" "839.7" "859.0" "837.2" "996.2" "803.6" "772.3" "499.9" "" "" "" "" "" "" "" "" "" "" "465.9" "466.7" "462.0" "386.7" "464.7" "465.7" "586.3" "438.7" "433.2" "499.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7233412111740596343" "False" "High" "IsMasterProtein" "P19367" "Hexokinase-1 OS=Homo sapiens OX=9606 GN=HK1 PE=1 SV=3" "0.000" "False" "34.255" "10" "11" "19" "10" "917" "102.4" "6.80" "47.74" "11" "other metabolic processes;stress response;other biological processes" "other membranes;cytosol;mitochondrion" "kinase activity;other molecular function" "Pf00349, Pf03727" "3098" "ENSG00000156515" "HK1" "E9PCK0; hsa:3098; O43443; O43444; O75574; P19367; Q5VTC3; Q96HC8; Q9NNZ4; Q9NNZ5" "Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Disorders of fructose metabolism; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "Glycolysis; Defective HK1 causes hexokinase deficiency (HK deficiency)" "12" "1" "1.009" "0.964" "1.008" "1.041" "1.102" "1.045" "1.095" "1.446" "0.707" "1938.4" "1956.0" "1868.9" "1953.7" "2018.2" "2136.2" "2025.6" "2122.1" "2803.8" "1371.2" "" "" "" "" "" "" "" "" "" "" "1026.4" "1084.4" "1070.3" "899.7" "1091.9" "1188.3" "1192.1" "1158.4" "1572.9" "1371.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3602347345364685954" "False" "High" "IsMasterProtein" "P09429" "High mobility group protein B1 OS=Homo sapiens OX=9606 GN=HMGB1 PE=1 SV=3" "0.000" "False" "34.233" "23" "5" "24" "5" "215" "24.9" "5.74" "78.93" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00505, Pf09011" "3146" "ENSG00000189403" "HMGB1" "A5D8W9; hsa:3146; P09429; Q14321; Q5T7C3; Q6IBE1" "Retinoblastoma gene in cancer; VEGFA-VEGFR2 signaling; Suppression of HMGB1-mediated inflammation by THBD; Base excision repair; DNA repair pathways, full network; Pleural mesothelioma; Clock-controlled autophagy in bone metabolism; Autophagy in pancreatic ductal adenocarcinoma; DNA damage response (only ATM dependent)" "ER-Phagosome pathway; Neutrophil degranulation; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Apoptosis induced DNA fragmentation; TAK1-dependent IKK and NF-kappa-B activation ; TRAF6 mediated NF-kB activation; Pyroptosis; Advanced glycosylation endproduct receptor signaling" "20" "0" "0.937" "1.086" "1.025" "0.966" "0.944" "0.998" "1.037" "1.010" "0.632" "2244.3" "2102.4" "2436.5" "2299.8" "2167.8" "2118.1" "2240.1" "2328.2" "2267.3" "1418.9" "" "" "" "" "" "" "" "" "" "" "1188.4" "1165.6" "1395.4" "1059.1" "1172.8" "1178.2" "1318.4" "1270.9" "1271.9" "1418.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8900163226744829744" "False" "High" "IsMasterProtein" "Q99590" "Protein SCAF11 OS=Homo sapiens OX=9606 GN=SCAF11 PE=1 SV=2" "0.000" "False" "34.230" "6" "10" "14" "10" "1463" "164.6" "8.41" "36.94" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf13639" "9169" "ENSG00000139218" "SCAF11" "A6NEU9; A6NLW5; hsa:9169; Q8IW59; Q99590" "Apoptosis" "" "1" "0" "1.297" "1.057" "1.171" "1.115" "1.099" "1.361" "1.514" "1.394" "0.631" "1090.0" "1413.8" "1151.5" "1276.5" "1215.3" "1198.2" "1483.3" "1650.0" "1519.6" "688.2" "" "" "" "" "" "" "" "" "" "" "577.1" "783.9" "659.5" "587.9" "657.5" "666.5" "873.0" "900.7" "852.5" "688.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4629403927496459035" "False" "High" "IsMasterProtein" "P62987" "Ubiquitin-ribosomal protein eL40 fusion protein OS=Homo sapiens OX=9606 GN=UBA52 PE=1 SV=2" "0.000" "False" "34.103" "46" "6" "68" "6" "128" "14.7" "9.83" "202.73" "6" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf01020" "7311" "ENSG00000221983" "UBA52" "hsa:7311; P02248; P02249; P02250; P14793; P62987; P62988; Q29120; Q6LBL4; Q6LDU5; Q8WYN8; Q91887; Q91888; Q9BWD6; Q9BX98; Q9UEF2; Q9UEG1; Q9UEK8; Q9UPK7" "DNA replication; Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Circadian Clock; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH1 Intracellular Domain Regulates Transcription; Downstream TCR signaling; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of PLK1 Activity at G2/M Transition; Regulation of TP53 Degradation; APC/C:Cdc20 mediated degradation of Cyclin B; Ovarian tumor domain proteases; FCERI mediated NF-kB activation; Regulation of signaling by CBL; Cyclin D associated events in G1; Inactivation of CSF3 (G-CSF) signaling; Signaling by CSF1 (M-CSF) in myeloid cells; Antigen processing: Ubiquitination & Proteasome degradation; KEAP1-NFE2L2 pathway; Regulation of innate immune responses to cytosolic DNA; Orc1 removal from chromatin; Assembly of the pre-replicative complex; Separation of Sister Chromatids; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; SARS-CoV-1 activates/modulates innate immune responses; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Stimuli-sensing channels; Amyloid fiber formation; Fanconi Anemia Pathway; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Aggrephagy; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 HD Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Peroxisomal protein import; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; ER Quality Control Compartment (ERQC); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Oxidative Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Signaling by ALK fusions and activated point mutants; Metalloprotease DUBs; Regulation of necroptotic cell death; Oncogene Induced Senescence; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Negative regulation of FLT3; Downregulation of ERBB2:ERBB3 signaling; Cargo recognition for clathrin-mediated endocytosis; Interferon alpha/beta signaling; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Regulation of TP53 Activity through Methylation; Processing of DNA double-strand break ends; Regulation of BACH1 activity; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Prevention of phagosomal-lysosomal fusion; Downregulation of TGF-beta receptor signaling; HDR through Homologous Recombination (HRR); TICAM1-dependent activation of IRF3/IRF7; TICAM1,TRAF6-dependent induction of TAK1 complex; Glycogen synthesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Modulation by Mtb of host immune system; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway; Spry regulation of FGF signaling; RAS processing; PINK1-PRKN Mediated Mitophagy; Josephin domain DUBs; Regulation of FZD by ubiquitination; Chaperone Mediated Autophagy; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; InlA-mediated entry of Listeria monocytogenes into host cells; Formation of Incision Complex in GG-NER; Iron uptake and transport; Recognition of DNA damage by PCNA-containing replication complex; VLDLR internalisation and degradation; Myoclonic epilepsy of Lafora; Evasion by RSV of host interferon responses; DNA Damage Recognition in GG-NER; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Negative regulation of MAPK pathway; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); NRIF signals cell death from the nucleus; Assembly Of The HIV Virion; Dual Incision in GG-NER; Translesion Synthesis by POLH; Downregulation of ERBB4 signaling; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Gap-filling DNA repair synthesis and ligation in GG-NER; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; Regulation of PTEN localization; Pexophagy; Maturation of protein E; Maturation of protein E; FLT3 signaling by CBL mutants; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "199" "0" "1.021" "1.067" "1.079" "1.001" "0.924" "0.996" "1.083" "0.898" "0.603" "7033.7" "7182.8" "7502.8" "7586.1" "7043.0" "6502.2" "7003.2" "7616.2" "6319.0" "4242.7" "" "" "" "" "" "" "" "" "" "" "3724.4" "3982.4" "4296.8" "3493.7" "3810.5" "3616.8" "4121.6" "4157.3" "3544.8" "4242.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1376480877538073283" "False" "High" "IsMasterProtein" "Q14232" "Translation initiation factor eIF2B subunit alpha OS=Homo sapiens OX=9606 GN=EIF2B1 PE=1 SV=1" "0.000" "False" "34.076" "24" "7" "11" "7" "305" "33.7" "7.33" "33.49" "7" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01008" "1967" "ENSG00000111361" "EIF2B1" "A6NLY9; B4DGX0; hsa:1967; Q14232; Q3SXP4" "Translation factors" "Recycling of eIF2:GDP" "2" "0" "0.977" "0.985" "0.959" "0.990" "1.003" "0.958" "0.985" "0.934" "0.684" "1564.6" "1528.1" "1541.3" "1500.5" "1548.3" "1569.3" "1498.8" "1541.2" "1462.0" "1069.7" "" "" "" "" "" "" "" "" "" "" "828.5" "847.2" "882.7" "691.0" "837.7" "872.9" "882.1" "841.3" "820.1" "1069.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6639457363078970209" "False" "High" "IsMasterProtein" "P35659" "Protein DEK OS=Homo sapiens OX=9606 GN=DEK PE=1 SV=1" "0.000" "False" "34.053" "21" "7" "11" "7" "375" "42.6" "8.56" "28.35" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf08766" "7913" "ENSG00000124795" "DEK" "B2R6K6; B4DN37; hsa:7913; P35659; Q5TGV4; Q5TGV5" "IL-18 signaling pathway; 10q11.21q11.23 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; Transcriptional regulation of granulopoiesis; Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors" "5" "0" "0.958" "1.017" "0.996" "1.061" "1.108" "0.984" "0.896" "1.026" "2.755" "1066.2" "1021.3" "1084.7" "1062.3" "1131.2" "1181.6" "1049.5" "955.4" "1094.2" "2937.9" "" "" "" "" "" "" "" "" "" "" "564.6" "566.2" "621.2" "489.2" "612.0" "657.3" "617.7" "521.5" "613.8" "2937.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "692688187917917011" "False" "High" "IsMasterProtein" "P82979" "SAP domain-containing ribonucleoprotein OS=Homo sapiens OX=9606 GN=SARNP PE=1 SV=3" "0.000" "False" "34.032" "30" "6" "14" "6" "210" "23.7" "6.42" "37.02" "6" "other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037" "84324" "ENSG00000205323" "SARNP" "A8K393; hsa:84324; P82979; Q9P066" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "1.004" "1.057" "1.063" "0.993" "0.975" "1.030" "1.131" "1.014" "0.487" "1985.3" "1993.7" "2099.0" "2110.4" "1972.0" "1935.9" "2044.2" "2244.8" "2012.8" "966.4" "" "" "" "" "" "" "" "" "" "" "1051.2" "1105.4" "1202.1" "971.9" "1066.9" "1076.9" "1203.1" "1225.3" "1129.1" "966.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8752239950939414056" "False" "High" "IsMasterProtein" "P18754" "Regulator of chromosome condensation OS=Homo sapiens OX=9606 GN=RCC1 PE=1 SV=1" "0.000" "False" "34.016" "16" "6" "12" "6" "421" "44.9" "7.52" "42.67" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00415" "1104" "ENSG00000180198" "RCC1" "hsa:1104; P18754; Q16269; Q6NT97" "22q11.2 copy number variation syndrome" "Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation" "4" "0" "0.934" "0.985" "1.086" "1.041" "1.052" "1.099" "0.623" "0.943" "4.793" "721.8" "674.0" "711.2" "783.7" "751.5" "759.5" "793.3" "450.0" "680.9" "3459.8" "" "" "" "" "" "" "" "" "" "" "382.2" "373.7" "407.3" "360.9" "406.6" "422.5" "466.9" "245.6" "382.0" "3459.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4414098033661647234" "False" "High" "IsMasterProtein" "O43488" "Aflatoxin B1 aldehyde reductase member 2 OS=Homo sapiens OX=9606 GN=AKR7A2 PE=1 SV=3" "0.000" "False" "33.976" "21" "7" "12" "7" "359" "39.6" "7.17" "29.62" "7" "other metabolic processes" "cytosol;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00248" "8574" "ENSG00000053371" "AKR7A2" "hsa:8574; O43488; O75749; Q5TG63" "Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II" "Aflatoxin activation and detoxification" "3" "0" "0.975" "1.030" "1.035" "0.968" "0.934" "0.981" "1.079" "0.806" "0.559" "1549.7" "1510.8" "1595.6" "1603.4" "1500.3" "1446.9" "1520.2" "1671.6" "1248.9" "866.9" "" "" "" "" "" "" "" "" "" "" "820.5" "837.7" "913.8" "738.4" "811.7" "804.8" "894.7" "912.4" "700.6" "866.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3813014236257881133" "False" "High" "IsMasterProtein" "P21291" "Cysteine and glycine-rich protein 1 OS=Homo sapiens OX=9606 GN=CSRP1 PE=1 SV=3" "0.000" "False" "33.909" "42" "6" "12" "6" "193" "20.6" "8.57" "38.25" "6" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00412" "1465" "ENSG00000159176" "CSRP1" "A8K268; hsa:1465; P21291; Q5U0J2" "MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling" "MTF1 activates gene expression" "3" "0" "0.947" "1.059" "1.030" "0.990" "0.957" "0.972" "1.005" "0.957" "0.533" "1121.5" "1062.1" "1187.2" "1155.0" "1109.9" "1073.7" "1089.8" "1127.3" "1072.8" "597.8" "" "" "" "" "" "" "" "" "" "" "593.8" "588.9" "679.9" "531.9" "600.5" "597.2" "641.4" "615.3" "601.8" "597.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7804593392060362224" "False" "High" "IsMasterProtein" "P14324" "Farnesyl pyrophosphate synthase OS=Homo sapiens OX=9606 GN=FDPS PE=1 SV=4" "0.000" "False" "33.825" "14" "6" "12" "6" "419" "48.2" "6.15" "35.35" "6" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00348" "2224" "ENSG00000160752" "FDPS" "D3DV91; E9PCI9; hsa:2224; P14324; Q96G29" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "9" "0" "0.950" "0.851" "1.006" "0.999" "0.908" "1.019" "0.875" "0.972" "2.506" "897.9" "853.2" "764.2" "903.5" "897.3" "815.4" "914.6" "785.3" "873.2" "2250.0" "" "" "" "" "" "" "" "" "" "" "475.4" "473.0" "437.6" "416.1" "485.5" "453.6" "538.2" "428.7" "489.8" "2250.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "52020500018808800" "False" "High" "IsMasterProtein" "Q9H773" "dCTP pyrophosphatase 1 OS=Homo sapiens OX=9606 GN=DCTPP1 PE=1 SV=1" "0.000" "False" "33.708" "38" "6" "12" "6" "170" "18.7" "5.03" "38.06" "6" "DNA metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf12643" "79077" "ENSG00000179958" "DCTPP1" "hsa:79077; Q9H773" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "1.051" "1.060" "1.118" "1.039" "1.021" "1.113" "1.182" "1.036" "0.637" "948.2" "996.7" "1005.6" "1060.2" "985.1" "967.7" "1055.3" "1120.7" "981.9" "603.7" "" "" "" "" "" "" "" "" "" "" "502.1" "552.6" "575.9" "488.3" "533.0" "538.3" "621.1" "611.8" "550.8" "603.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8263646129409186084" "False" "High" "IsMasterProtein" "Q14814" "Myocyte-specific enhancer factor 2D OS=Homo sapiens OX=9606 GN=MEF2D PE=1 SV=1" "0.000" "False" "33.678" "16" "8" "12" "6" "521" "55.9" "7.88" "39.62" "8" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319, Pf12347" "4209" "ENSG00000116604; ENSG00000291761" "MEF2D" "D3DVC0; hsa:4209; Q14814; Q14815; Q5T9U5; Q5T9U6" "Energy metabolism; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; B cell receptor signaling pathway; Adipogenesis; p38 MAPK signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; EGF/EGFR signaling pathway; Gastrin signaling pathway; Modulators of TCR signaling and T cell activation; Pleural mesothelioma; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "Heme signaling; NGF-stimulated transcription; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; Myogenesis" "18" "2" "1.015" "0.978" "1.048" "0.990" "0.943" "0.961" "0.953" "0.907" "0.767" "1403.2" "1424.5" "1372.0" "1470.6" "1388.7" "1322.8" "1348.1" "1337.1" "1272.5" "1076.6" "" "" "" "" "" "" "" "" "" "" "743.0" "789.8" "785.7" "677.3" "751.3" "735.8" "793.4" "729.8" "713.8" "1076.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3042753504910158627" "False" "High" "IsMasterProtein" "P13804" "Electron transfer flavoprotein subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ETFA PE=1 SV=1" "0.000" "False" "33.674" "29" "9" "13" "9" "333" "35.1" "8.38" "41.25" "9" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00766, Pf01012" "2108" "ENSG00000140374" "ETFA" "B4DT43; hsa:2108; P13804; Q53XN3" "" "Respiratory electron transport" "1" "0" "0.984" "0.984" "0.950" "0.962" "1.033" "0.927" "0.987" "0.896" "0.645" "1898.1" "1868.1" "1867.7" "1802.5" "1826.8" "1961.3" "1758.9" "1874.0" "1700.9" "1224.0" "" "" "" "" "" "" "" "" "" "" "1005.0" "1035.7" "1069.6" "830.1" "988.4" "1090.9" "1035.2" "1022.9" "954.2" "1224.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1683899515612259900" "False" "High" "IsMasterProtein" "O94776" "Metastasis-associated protein MTA2 OS=Homo sapiens OX=9606 GN=MTA2 PE=1 SV=1" "0.000" "False" "33.661" "13" "9" "13" "8" "668" "75.0" "9.66" "40.68" "9" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf00320, Pf01426, Pf01448, Pf17226" "9219" "ENSG00000149480" "MTA2" "hsa:9219; O94776; Q68DB1; Q9UQB5" "Effect of progerin on genes involved in progeria" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "7" "0" "0.921" "1.000" "1.058" "0.882" "0.910" "1.065" "1.020" "1.130" "2.249" "660.1" "608.2" "659.9" "698.8" "581.9" "601.1" "703.1" "673.4" "746.2" "1484.8" "" "" "" "" "" "" "" "" "" "" "349.5" "337.2" "377.9" "321.8" "314.8" "334.3" "413.8" "367.6" "418.6" "1484.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1629883586476679929" "False" "High" "IsMasterProtein" "Q9BT78" "COP9 signalosome complex subunit 4 OS=Homo sapiens OX=9606 GN=COPS4 PE=1 SV=1" "0.000" "False" "33.629" "16" "6" "15" "6" "406" "46.2" "5.83" "43.34" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01399, Pf18420" "51138" "ENSG00000138663" "COPS4" "B3KN88; B3KST5; hsa:51138; Q561W7; Q9BT78; Q9NW31; Q9Y677" "Ciliary landscape" "Cargo recognition for clathrin-mediated endocytosis; Neddylation; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER; RHOBTB1 GTPase cycle" "6" "0" "0.999" "1.000" "1.046" "1.032" "0.983" "1.001" "0.987" "0.994" "0.684" "1475.6" "1473.7" "1476.2" "1544.0" "1522.5" "1450.3" "1477.4" "1456.9" "1466.5" "1008.6" "" "" "" "" "" "" "" "" "" "" "781.3" "817.0" "845.4" "711.1" "823.7" "806.7" "869.5" "795.3" "822.7" "1008.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2660523182149503333" "False" "High" "IsMasterProtein" "Q9UKK9" "ADP-sugar pyrophosphatase OS=Homo sapiens OX=9606 GN=NUDT5 PE=1 SV=1" "0.000" "False" "33.622" "17" "3" "15" "3" "219" "24.3" "4.94" "45.11" "3" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00293" "11164" "ENSG00000165609" "NUDT5" "A8K516; hsa:11164; Q6IAG0; Q9UH49; Q9UKK9" "" "Phosphate bond hydrolysis by NUDT proteins" "1" "0" "1.165" "1.014" "0.847" "1.018" "0.916" "0.947" "0.933" "0.942" "0.513" "1182.2" "1377.5" "1198.8" "1000.9" "1203.2" "1082.9" "1120.1" "1103.4" "1113.9" "606.0" "" "" "" "" "" "" "" "" "" "" "626.0" "763.7" "686.5" "460.9" "651.0" "602.4" "659.2" "602.3" "624.9" "606.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2256235105362563928" "False" "High" "IsMasterProtein" "P62937" "Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens OX=9606 GN=PPIA PE=1 SV=2" "0.000" "False" "33.619" "48" "9" "46" "8" "165" "18.0" "7.81" "97.94" "9" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00160" "5478" "ENSG00000196262" "PPIA" "A8K220; hsa:5478; P05092; P62937; Q3KQW3; Q567Q0; Q6IBU5; Q96IX3; Q9BRU4; Q9BTY9; Q9UC61" "Prolactin signaling pathway" "Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Budding and maturation of HIV virion; Platelet degranulation ; Basigin interactions; SARS-CoV-1 activates/modulates innate immune responses; Integration of provirus; APOBEC3G mediated resistance to HIV-1 infection; Calcineurin activates NFAT; Binding and entry of HIV virion; Assembly Of The HIV Virion; Uncoating of the HIV Virion; Minus-strand DNA synthesis; Plus-strand DNA synthesis" "16" "1" "0.993" "0.951" "0.940" "0.988" "1.011" "1.001" "0.908" "0.953" "1.106" "2774.3" "2754.6" "2638.9" "2607.7" "2741.2" "2806.2" "2777.6" "2520.1" "2644.8" "3069.7" "" "" "" "" "" "" "" "" "" "" "1469.0" "1527.2" "1511.3" "1200.9" "1483.1" "1560.9" "1634.7" "1375.6" "1483.7" "3069.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "251900378438964283" "False" "High" "IsMasterProtein" "Q13188" "Serine/threonine-protein kinase 3 OS=Homo sapiens OX=9606 GN=STK3 PE=1 SV=2" "0.000" "False" "33.466" "21" "10" "13" "6" "491" "56.3" "5.24" "28.40" "10" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf11629" "6788" "ENSG00000104375" "STK3" "A8K722; B3KYA7; hsa:6788; Q13188; Q15445; Q15801; Q96FM6" "MAPK signaling pathway; Transcription co-factors SKI and SKIL protein partners; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Leukocyte-intrinsic Hippo pathway functions; Pleural mesothelioma" "Signaling by Hippo" "9" "2" "1.011" "1.022" "1.065" "1.059" "1.025" "1.035" "1.038" "0.971" "0.733" "779.8" "788.2" "796.9" "830.8" "825.5" "799.5" "807.1" "809.5" "756.9" "571.6" "" "" "" "" "" "" "" "" "" "" "412.9" "437.0" "456.4" "382.6" "446.6" "444.7" "475.0" "441.9" "424.6" "571.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2120449807322374936" "False" "High" "IsMasterProtein" "Q9Y2Z0" "Protein SGT1 homolog OS=Homo sapiens OX=9606 GN=SUGT1 PE=1 SV=3" "0.000" "False" "33.340" "21" "8" "12" "8" "365" "41.0" "5.16" "29.62" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04969, Pf05002" "10910" "ENSG00000165416" "SUGT1" "A2A303; hsa:10910; Q5JAK5; Q5TAM6; Q6VXY6; Q9Y2Z0" "Nucleotide-binding oligomerization domain (NOD) pathway" "The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection" "3" "0" "1.029" "1.045" "1.036" "1.096" "1.027" "1.021" "1.065" "1.110" "1.163" "1057.4" "1087.7" "1104.6" "1095.4" "1159.0" "1086.2" "1079.6" "1126.3" "1174.0" "1230.0" "" "" "" "" "" "" "" "" "" "" "559.9" "603.1" "632.6" "504.5" "627.1" "604.2" "635.4" "614.8" "658.6" "1230.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3009900426920291332" "False" "High" "IsMasterProtein" "B5ME19" "Eukaryotic translation initiation factor 3 subunit C-like protein OS=Homo sapiens OX=9606 GN=EIF3CL PE=1 SV=1" "0.000" "False" "33.327" "10" "10" "14" "10" "914" "105.4" "5.64" "38.05" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes" "translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01399, Pf05470" "728689" "ENSG00000205609" "EIF3CL" "B5ME19; hsa:728689" "" "" "0" "0" "1.070" "1.073" "1.116" "1.119" "1.026" "1.071" "0.745" "0.944" "3.311" "803.5" "859.6" "862.0" "896.4" "899.4" "824.6" "860.9" "598.4" "758.9" "2660.2" "" "" "" "" "" "" "" "" "" "" "425.5" "476.6" "493.6" "412.8" "486.6" "458.7" "506.7" "326.6" "425.7" "2660.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1694253408134936187" "False" "High" "IsMasterProtein" "P50452" "Serpin B8 OS=Homo sapiens OX=9606 GN=SERPINB8 PE=1 SV=2" "0.000" "False" "33.300" "19" "7" "17" "6" "374" "42.7" "5.57" "43.21" "7" "cell adhesion;other biological processes" "non-structural extracellular;cytosol;other cell component" "enzyme regulator activity" "Pf00079" "5271" "ENSG00000166401" "SERPINB8" "B4DTW2; P50452; Q7Z2V6; Q8N178" "" "Dissolution of Fibrin Clot" "1" "0" "1.054" "1.011" "1.119" "1.059" "1.047" "1.082" "1.033" "0.974" "0.653" "801.8" "845.1" "810.9" "897.3" "849.0" "839.5" "867.9" "828.5" "780.9" "523.7" "" "" "" "" "" "" "" "" "" "" "424.6" "468.5" "464.4" "413.2" "459.4" "467.0" "510.8" "452.2" "438.1" "523.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5794386193398091018" "False" "High" "IsMasterProtein" "Q9NY33" "Dipeptidyl peptidase 3 OS=Homo sapiens OX=9606 GN=DPP3 PE=1 SV=2" "0.000" "False" "33.295" "11" "8" "14" "8" "737" "82.5" "5.10" "35.81" "8" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf03571" "10072" "ENSG00000254986" "DPP3" "B2RDB5; B4DLX4; F5H8L6; hsa:10072; O95748; Q969H2; Q9BV67; Q9HAL6; Q9NY33" "" "Neddylation; KEAP1-NFE2L2 pathway" "2" "0" "0.921" "0.933" "0.930" "0.987" "0.946" "0.931" "0.960" "0.925" "0.796" "1276.8" "1176.3" "1190.7" "1187.6" "1260.2" "1208.3" "1189.3" "1225.2" "1181.0" "1015.8" "" "" "" "" "" "" "" "" "" "" "676.0" "652.2" "681.9" "546.9" "681.8" "672.1" "699.9" "668.8" "662.5" "1015.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3541019235990541605" "False" "High" "IsMasterProtein" "Q9UNM6" "26S proteasome non-ATPase regulatory subunit 13 OS=Homo sapiens OX=9606 GN=PSMD13 PE=1 SV=2" "0.000" "False" "33.294" "23" "10" "17" "10" "376" "42.9" "5.81" "44.49" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01399" "5719" "ENSG00000185627" "PSMD13" "B3KT15; hsa:5719; O75831; Q53XU2; Q9UNM6; Q9UNV3" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "65" "0" "1.020" "1.018" "1.053" "1.004" "1.067" "1.003" "0.944" "0.926" "0.796" "1720.0" "1754.0" "1751.5" "1811.9" "1726.1" "1835.0" "1725.2" "1622.9" "1593.0" "1369.1" "" "" "" "" "" "" "" "" "" "" "910.8" "972.4" "1003.1" "834.4" "933.9" "1020.7" "1015.3" "885.9" "893.6" "1369.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4060364465058462245" "False" "High" "IsMasterProtein" "Q15435" "Protein phosphatase 1 regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PPP1R7 PE=1 SV=1" "0.000" "False" "33.285" "23" "8" "13" "8" "360" "41.5" "4.91" "32.84" "8" "other biological processes" "other cell component" "enzyme regulator activity" "Pf12799, Pf14580" "5510" "ENSG00000115685" "PPP1R7" "B4DFD4; B5MCY6; hsa:5510; Q15435; Q9UQE5; Q9UQE6; Q9Y6K4" "2q37 copy number variation syndrome" "" "1" "0" "1.016" "1.086" "1.005" "0.962" "1.023" "0.971" "0.948" "0.938" "0.860" "784.9" "797.4" "852.0" "789.2" "755.0" "803.2" "761.8" "744.2" "736.6" "675.3" "" "" "" "" "" "" "" "" "" "" "415.6" "442.1" "488.0" "363.4" "408.5" "446.8" "448.3" "406.2" "413.2" "675.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5216339322949848557" "False" "High" "IsMasterProtein" "Q96PZ0" "Pseudouridylate synthase 7 homolog OS=Homo sapiens OX=9606 GN=PUS7 PE=1 SV=2" "0.000" "False" "33.240" "16" "9" "11" "9" "661" "75.0" "6.37" "25.64" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01142" "54517" "ENSG00000091127" "PUS7" "hsa:54517; Q75MG4; Q96PZ0; Q9NX19" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.037" "1.050" "1.021" "1.002" "1.109" "1.059" "1.017" "1.017" "0.928" "378.3" "392.3" "397.0" "386.3" "379.1" "419.5" "400.8" "384.6" "384.8" "350.9" "" "" "" "" "" "" "" "" "" "" "200.3" "217.5" "227.4" "177.9" "205.1" "233.3" "235.9" "209.9" "215.9" "350.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6077570543552496726" "False" "High" "IsMasterProtein" "Q8N1G4" "Leucine-rich repeat-containing protein 47 OS=Homo sapiens OX=9606 GN=LRRC47 PE=1 SV=1" "0.000" "False" "33.199" "14" "8" "15" "8" "583" "63.4" "8.28" "43.33" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf00560, Pf13855" "57470" "ENSG00000130764" "LRRC47" "hsa:57470; Q8N1G4; Q9ULN5" "" "" "0" "0" "1.001" "0.966" "1.031" "1.025" "0.982" "0.917" "0.979" "0.883" "0.706" "809.3" "810.3" "781.8" "834.3" "829.3" "794.7" "741.8" "792.2" "714.2" "571.0" "" "" "" "" "" "" "" "" "" "" "428.5" "449.3" "447.8" "384.2" "448.7" "442.1" "436.6" "432.4" "400.7" "571.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1728322554936911435" "False" "High" "IsMasterProtein" "Q14978" "Nucleolar and coiled-body phosphoprotein 1 OS=Homo sapiens OX=9606 GN=NOLC1 PE=1 SV=2" "0.000" "False" "33.048" "11" "9" "15" "9" "699" "73.6" "9.47" "43.73" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05022" "9221" "ENSG00000166197" "NOLC1" "hsa:9221; Q14978; Q15030; Q5VV70; Q9BUV3" "" "" "0" "0" "0.986" "1.125" "1.141" "1.138" "1.089" "1.351" "1.366" "1.509" "0.830" "1134.8" "1119.4" "1276.7" "1294.5" "1291.6" "1235.4" "1532.7" "1549.7" "1712.6" "941.8" "" "" "" "" "" "" "" "" "" "" "600.9" "620.6" "731.2" "596.1" "698.8" "687.2" "902.0" "845.9" "960.7" "941.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5070657134179306573" "False" "High" "IsMasterProtein" "P55160" "Nck-associated protein 1-like OS=Homo sapiens OX=9606 GN=NCKAP1L PE=1 SV=3" "0.000" "False" "32.999" "9" "10" "11" "10" "1127" "128.1" "6.86" "26.33" "10" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf09735" "3071" "ENSG00000123338" "NCKAP1L" "B4DUT5; hsa:3071; P55160; Q52LW0" "Hematopoietic stem cell differentiation; Microglia pathogen phagocytosis pathway; TYROBP causal network in microglia" "Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway" "11" "0" "0.989" "0.976" "1.007" "0.945" "0.972" "0.849" "0.897" "0.902" "1.362" "1126.9" "1114.5" "1100.0" "1135.1" "1065.3" "1095.8" "956.6" "1010.7" "1016.5" "1534.6" "" "" "" "" "" "" "" "" "" "" "596.7" "617.9" "629.9" "522.7" "576.4" "609.5" "563.0" "551.7" "570.2" "1534.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9022416781062355686" "False" "High" "IsMasterProtein" "Q9UPU5" "Ubiquitin carboxyl-terminal hydrolase 24 OS=Homo sapiens OX=9606 GN=USP24 PE=1 SV=3" "0.000" "False" "32.910" "5" "12" "12" "12" "2620" "294.2" "6.14" "24.76" "12" "protein metabolism" "cytosol;nucleus" "other molecular function" "Pf00443" "23358" "ENSG00000162402" "USP24" "hsa:23358; Q6ZSY2; Q8N2Y4; Q9NXD1; Q9UPU5" "" "Ub-specific processing proteases" "1" "0" "1.059" "1.017" "0.921" "0.945" "0.879" "0.868" "0.855" "0.873" "1.139" "820.3" "868.9" "834.4" "755.8" "775.4" "720.7" "711.9" "701.0" "716.3" "934.4" "" "" "" "" "" "" "" "" "" "" "434.4" "481.7" "477.9" "348.1" "419.5" "400.9" "419.0" "382.7" "401.8" "934.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "32097797701443302" "False" "High" "IsMasterProtein" "Q14008" "Cytoskeleton-associated protein 5 OS=Homo sapiens OX=9606 GN=CKAP5 PE=1 SV=3" "0.000" "False" "32.851" "4" "8" "11" "8" "2032" "225.4" "7.80" "25.46" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02985, Pf12348, Pf21041" "9793" "ENSG00000175216" "CKAP5" "hsa:9793; Q05D70; Q0VAX7; Q0VAX8; Q14008; Q14668; Q2TA89; Q6NSH4" "4p16.3 copy number variation" "Separation of Sister Chromatids; Regulation of PLK1 Activity at G2/M Transition; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "14" "0" "1.066" "0.953" "1.141" "1.195" "1.138" "1.322" "0.857" "1.309" "6.092" "456.5" "486.5" "435.0" "521.0" "545.5" "519.6" "603.7" "391.1" "597.4" "2781.5" "" "" "" "" "" "" "" "" "" "" "241.7" "269.7" "249.1" "239.9" "295.1" "289.0" "355.3" "213.5" "335.1" "2781.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3460049962588220827" "False" "High" "IsMasterProtein" "Q96CX2" "BTB/POZ domain-containing protein KCTD12 OS=Homo sapiens OX=9606 GN=KCTD12 PE=1 SV=1" "0.000" "False" "32.803" "21" "6" "8" "6" "325" "35.7" "5.64" "20.56" "6" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf02214" "115207" "ENSG00000178695" "KCTD12" "hsa:115207; Q96CX2" "" "" "0" "0" "1.100" "1.097" "1.150" "1.063" "1.078" "1.145" "1.106" "1.087" "0.672" "395.6" "435.1" "434.0" "455.0" "420.5" "426.4" "452.8" "437.6" "430.1" "266.0" "" "" "" "" "" "" "" "" "" "" "209.5" "241.2" "248.6" "209.5" "227.5" "237.2" "266.5" "238.8" "241.3" "266.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8488092828150113306" "False" "High" "IsMasterProtein" "Q86UX7" "Fermitin family homolog 3 OS=Homo sapiens OX=9606 GN=FERMT3 PE=1 SV=1" "0.000" "False" "32.740" "14" "6" "10" "6" "667" "75.9" "6.98" "25.62" "6" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "non-structural extracellular;cytoskeleton;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00169, Pf00373, Pf18124" "83706" "ENSG00000149781" "FERMT3" "hsa:83706; Q86UX7; Q8IUA1; Q8N207; Q9BT48" "Leukocyte-intrinsic Hippo pathway functions" "Platelet degranulation" "2" "0" "1.088" "1.055" "0.926" "1.053" "1.138" "0.860" "0.852" "1.023" "2.294" "528.3" "574.8" "557.2" "489.0" "556.2" "601.1" "454.5" "450.0" "540.3" "1211.8" "" "" "" "" "" "" "" "" "" "" "279.7" "318.7" "319.1" "225.2" "300.9" "334.3" "267.5" "245.6" "303.1" "1211.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-16918109513615625" "False" "High" "IsMasterProtein" "P51149" "Ras-related protein Rab-7a OS=Homo sapiens OX=9606 GN=RAB7A PE=1 SV=1" "0.000" "False" "32.736" "28" "5" "11" "5" "207" "23.5" "6.70" "28.86" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "7879" "ENSG00000075785" "RAB7A" "A8K3V6; hsa:7879; P51149; Q9NWJ0; Q9UPB0" "Ebola virus infection in host; Autosomal recessive osteopetrosis pathways; Intracellular trafficking proteins involved in CMT neuropathy" "RHOG GTPase cycle; TBC/RABGAPs; Neutrophil degranulation; Prevention of phagosomal-lysosomal fusion; RAB geranylgeranylation; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAB GEFs exchange GTP for GDP on RABs; MHC class II antigen presentation; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Suppression of autophagy; RHOH GTPase cycle" "20" "0" "0.864" "0.849" "0.830" "0.749" "0.904" "0.960" "0.852" "0.744" "0.516" "813.5" "703.0" "691.0" "675.2" "609.0" "735.6" "780.9" "693.5" "605.0" "419.5" "" "" "" "" "" "" "" "" "" "" "430.8" "389.7" "395.7" "311.0" "329.5" "409.2" "459.6" "378.5" "339.4" "419.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7014036665860809700" "False" "High" "IsMasterProtein" "Q13459" "Unconventional myosin-IXb OS=Homo sapiens OX=9606 GN=MYO9B PE=1 SV=3" "0.000" "False" "32.710" "5" "11" "11" "11" "2157" "243.2" "8.75" "24.37" "11" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00063, Pf00612, Pf00620, Pf00788" "4650" "ENSG00000099331" "MYO9B" "hsa:4650; O75314; Q13459; Q9NUJ2; Q9UHN0" "Vitamin D receptor pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHOA GTPase cycle; RAC1 GTPase cycle; RHOC GTPase cycle; CDC42 GTPase cycle; RHOB GTPase cycle; RHOF GTPase cycle; SLIT2:ROBO1 increases RHOA activity" "10" "0" "1.018" "0.986" "1.035" "1.062" "1.100" "1.078" "0.881" "1.057" "2.561" "647.7" "659.6" "638.4" "670.4" "687.5" "712.4" "698.4" "570.3" "684.3" "1658.8" "" "" "" "" "" "" "" "" "" "" "342.9" "365.7" "365.6" "308.7" "372.0" "396.3" "411.0" "311.3" "383.9" "1658.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-566189082840404496" "False" "High" "IsMasterProtein" "Q8WVM7" "Cohesin subunit SA-1 OS=Homo sapiens OX=9606 GN=STAG1 PE=1 SV=3" "0.000" "False" "32.679" "9" "10" "12" "9" "1258" "144.3" "5.59" "32.59" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08514, Pf21581" "10274" "ENSG00000118007" "STAG1" "hsa:10274; O00539; Q6P275; Q8WVM7" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; 10q22q23 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; Estrogen-dependent gene expression; SUMOylation of DNA damage response and repair proteins; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "10" "0" "1.050" "1.036" "1.013" "1.043" "1.058" "0.929" "0.886" "0.950" "0.934" "1023.7" "1074.5" "1060.4" "1036.8" "1067.3" "1083.6" "950.7" "906.6" "972.4" "955.9" "" "" "" "" "" "" "" "" "" "" "542.1" "595.7" "607.3" "477.5" "577.5" "602.7" "559.5" "494.9" "545.5" "955.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9193943049168300683" "False" "High" "IsMasterProtein" "Q02818" "Nucleobindin-1 OS=Homo sapiens OX=9606 GN=NUCB1 PE=1 SV=4" "0.000" "False" "32.677" "20" "9" "11" "9" "461" "53.8" "5.25" "31.23" "9" "signal transduction" "ER/Golgi" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "" "4924" "ENSG00000104805" "NUCB1" "B2RD64; hsa:4924; Q02818; Q15838; Q7Z4J7; Q9BUR1" "" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "2" "0" "0.987" "1.026" "1.044" "1.020" "0.945" "1.002" "1.050" "0.967" "0.731" "519.0" "512.4" "532.5" "541.9" "529.4" "490.7" "520.3" "545.2" "501.7" "379.5" "" "" "" "" "" "" "" "" "" "" "274.8" "284.1" "305.0" "249.5" "286.4" "273.0" "306.2" "297.6" "281.5" "379.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4054510205684443302" "False" "High" "IsMasterProtein" "Q9Y6X8" "Zinc fingers and homeoboxes protein 2 OS=Homo sapiens OX=9606 GN=ZHX2 PE=1 SV=1" "0.000" "False" "32.641" "11" "8" "9" "8" "837" "92.3" "6.86" "28.50" "8" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf18387" "22882" "ENSG00000178764" "ZHX2" "hsa:22882; Q9Y6X8" "" "" "0" "0" "1.291" "1.207" "1.363" "1.067" "1.059" "1.337" "1.131" "1.353" "4.044" "316.8" "409.0" "382.3" "431.8" "338.1" "335.5" "423.7" "358.2" "428.6" "1281.1" "" "" "" "" "" "" "" "" "" "" "167.8" "226.8" "218.9" "198.9" "182.9" "186.6" "249.3" "195.5" "240.4" "1281.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7866800410965669169" "False" "High" "IsMasterProtein" "Q9H0G5" "Nuclear speckle splicing regulatory protein 1 OS=Homo sapiens OX=9606 GN=NSRP1 PE=1 SV=1" "0.000" "False" "32.633" "15" "8" "11" "8" "558" "66.4" "8.84" "30.35" "8" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf09745, Pf20427" "84081" "ENSG00000126653" "NSRP1" "hsa:84081; Q6FI71; Q9H0G5" "" "mRNA Splicing - Major Pathway" "1" "0" "1.017" "1.043" "1.067" "1.022" "1.039" "1.190" "1.250" "1.178" "0.583" "1068.4" "1086.5" "1114.1" "1139.6" "1091.8" "1110.6" "1271.7" "1335.4" "1258.4" "622.6" "" "" "" "" "" "" "" "" "" "" "565.7" "602.4" "638.1" "524.8" "590.7" "617.8" "748.4" "729.0" "705.9" "622.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7303961078788059209" "False" "High" "IsMasterProtein" "P49792" "E3 SUMO-protein ligase RanBP2 OS=Homo sapiens OX=9606 GN=RANBP2 PE=1 SV=2" "0.000" "False" "32.632" "4" "11" "12" "9" "3224" "358.0" "6.20" "34.84" "11" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00160, Pf00638, Pf00641, Pf12185" "5903" "ENSG00000153201" "RANBP2" "hsa:5903; P49792; Q13074; Q15280; Q53TE2; Q59FH7" "" "RHO GTPases Activate Formins; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; SARS-CoV-2 activates/modulates innate and adaptive immune responses; tRNA processing in the nucleus; Separation of Sister Chromatids; Rev-mediated nuclear export of HIV RNA; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Signaling by ALK fusions and activated point mutants" "35" "1" "0.973" "0.965" "1.055" "1.053" "1.036" "1.357" "1.272" "1.339" "2.701" "643.3" "626.2" "620.7" "678.5" "677.2" "666.5" "873.2" "818.0" "861.5" "1737.7" "" "" "" "" "" "" "" "" "" "" "340.6" "347.2" "355.5" "312.5" "366.4" "370.7" "513.9" "446.5" "483.3" "1737.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1917909410339364485" "False" "High" "IsMasterProtein" "Q96QC0" "Serine/threonine-protein phosphatase 1 regulatory subunit 10 OS=Homo sapiens OX=9606 GN=PPP1R10 PE=1 SV=1" "0.000" "False" "32.582" "11" "11" "14" "11" "940" "99.0" "9.17" "37.30" "11" "transport;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00642, Pf08711" "5514" "ENSG00000204569; ENSG00000206489; ENSG00000227804; ENSG00000230995; ENSG00000231737; ENSG00000235291; ENSG00000238104" "PPP1R10" "hsa:5514; O00405; Q96QC0" "" "" "0" "0" "1.038" "0.965" "1.011" "1.031" "1.042" "1.121" "1.102" "1.155" "1.119" "933.1" "968.1" "900.1" "943.3" "961.8" "972.6" "1046.4" "1028.5" "1077.4" "1043.8" "" "" "" "" "" "" "" "" "" "" "494.1" "536.8" "515.5" "434.4" "520.4" "541.0" "615.8" "561.4" "604.4" "1043.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5964794776079938030" "False" "High" "IsMasterProtein" "P56537" "Eukaryotic translation initiation factor 6 OS=Homo sapiens OX=9606 GN=EIF6 PE=1 SV=1" "0.000" "False" "32.489" "31" "6" "12" "6" "245" "26.6" "4.68" "32.07" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf01912" "3692" "ENSG00000242372" "EIF6" "B7ZBG9; hsa:3692; P56537; Q6IBN8; Q96TD5" "Translation factors; Genetic causes of porto-sinusoidal vascular disease" "" "2" "0" "1.082" "0.981" "1.254" "1.209" "1.191" "1.441" "1.299" "1.263" "0.940" "622.9" "674.0" "611.2" "780.9" "752.9" "741.6" "897.7" "809.4" "786.6" "585.4" "" "" "" "" "" "" "" "" "" "" "329.8" "373.7" "350.0" "359.7" "407.3" "412.5" "528.3" "441.8" "441.3" "585.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8827666052570193854" "False" "High" "IsMasterProtein" "Q15056" "Eukaryotic translation initiation factor 4H OS=Homo sapiens OX=9606 GN=EIF4H PE=1 SV=5" "0.000" "False" "32.474" "23" "7" "19" "7" "248" "27.4" "7.23" "50.92" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00076" "7458" "ENSG00000106682" "EIF4H" "A8K3R1; D3DXF6; D3DXF8; hsa:7458; Q15056" "Translation factors; 7q11.23 copy number variation syndrome" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Ribosomal scanning and start codon recognition" "7" "0" "0.958" "1.060" "1.068" "0.983" "0.949" "1.101" "0.965" "0.995" "0.937" "1145.3" "1096.9" "1214.4" "1223.7" "1126.4" "1087.2" "1260.9" "1105.6" "1139.5" "1073.1" "" "" "" "" "" "" "" "" "" "" "606.4" "608.1" "695.5" "563.5" "609.4" "604.8" "742.1" "603.5" "639.2" "1073.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6094529598036827804" "False" "High" "IsMasterProtein" "Q13442" "28 kDa heat- and acid-stable phosphoprotein OS=Homo sapiens OX=9606 GN=PDAP1 PE=1 SV=1" "0.000" "False" "32.454" "32" "5" "9" "5" "181" "20.6" "8.87" "33.25" "5" "signal transduction" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "" "Pf10252" "11333" "ENSG00000106244" "PDAP1" "D6W5S5; hsa:11333; Q13442; Q92906" "" "Neutrophil degranulation" "1" "0" "0.981" "0.985" "1.048" "1.016" "0.891" "1.054" "0.934" "0.915" "0.406" "1790.7" "1755.8" "1763.6" "1876.9" "1819.0" "1595.2" "1887.8" "1672.4" "1637.9" "727.1" "" "" "" "" "" "" "" "" "" "" "948.2" "973.5" "1010.0" "864.4" "984.2" "887.3" "1111.0" "912.9" "918.8" "727.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8973265240341480372" "False" "High" "IsMasterProtein" "Q06203" "Amidophosphoribosyltransferase OS=Homo sapiens OX=9606 GN=PPAT PE=1 SV=1" "0.000" "False" "32.417" "16" "7" "10" "7" "517" "57.4" "6.76" "32.35" "7" "other metabolic processes" "cytosol" "other molecular function" "Pf00156, Pf13522" "5471" "ENSG00000128059" "PPAT" "hsa:5471; Q06203" "Fluoropyrimidine activity; Metabolic reprogramming in colon cancer" "Purine ribonucleoside monophosphate biosynthesis" "3" "0" "1.024" "0.995" "1.121" "0.979" "1.015" "1.110" "1.109" "1.068" "0.650" "1308.5" "1340.4" "1301.9" "1466.9" "1280.9" "1327.5" "1452.9" "1451.1" "1397.5" "850.0" "" "" "" "" "" "" "" "" "" "" "692.8" "743.1" "745.6" "675.6" "693.0" "738.4" "855.1" "792.1" "784.0" "850.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6184092773991491015" "False" "High" "IsMasterProtein" "P39748" "Flap endonuclease 1 OS=Homo sapiens OX=9606 GN=FEN1 PE=1 SV=1" "0.000" "False" "32.389" "22" "7" "10" "7" "380" "42.6" "8.62" "29.86" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00752, Pf00867" "2237" "ENSG00000168496" "FEN1" "hsa:2237; P39748" "Base excision repair; DNA repair pathways, full network" "HDR through MMEJ (alt-NHEJ); Early Phase of HIV Life Cycle; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Removal of the Flap Intermediate; Removal of the Flap Intermediate from the C-strand" "8" "0" "0.935" "0.947" "0.932" "0.900" "0.963" "0.912" "0.761" "0.882" "3.393" "491.6" "459.5" "465.5" "458.3" "442.5" "473.6" "448.5" "374.3" "433.5" "1667.9" "" "" "" "" "" "" "" "" "" "" "260.3" "254.7" "266.6" "211.1" "239.4" "263.4" "264.0" "204.3" "243.2" "1667.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3200158126373336546" "False" "High" "IsMasterProtein" "Q6IBS0" "Twinfilin-2 OS=Homo sapiens OX=9606 GN=TWF2 PE=1 SV=2" "0.000" "False" "32.367" "22" "7" "10" "6" "349" "39.5" "6.84" "28.84" "7" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "11344" "ENSG00000247596" "TWF2" "hsa:11344; Q6IBS0; Q9Y3F5" "" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "2" "1" "1.012" "1.023" "0.985" "0.990" "1.033" "1.057" "1.088" "1.027" "0.653" "1193.5" "1207.5" "1220.5" "1175.5" "1181.2" "1233.4" "1261.4" "1298.1" "1226.0" "779.7" "" "" "" "" "" "" "" "" "" "" "632.0" "669.5" "699.0" "541.4" "639.1" "686.1" "742.4" "708.6" "687.7" "779.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1037912225033679960" "False" "High" "IsMasterProtein" "P47756" "F-actin-capping protein subunit beta OS=Homo sapiens OX=9606 GN=CAPZB PE=1 SV=5" "0.000" "False" "32.363" "25" "7" "16" "7" "272" "30.6" "6.00" "48.27" "7" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01115" "832" "ENSG00000077549" "CAPZB" "hsa:832; P47756; Q32Q68; Q5U0L4; Q8TB49; Q9NUC4" "VEGFA-VEGFR2 signaling" "MHC class II antigen presentation; Sensory processing of sound by inner hair cells of the cochlea; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; RHOD GTPase cycle; RHOF GTPase cycle; Factors involved in megakaryocyte development and platelet production" "9" "0" "0.905" "1.064" "0.887" "0.903" "1.083" "1.005" "1.192" "1.176" "0.704" "1733.1" "1567.9" "1843.4" "1537.1" "1564.5" "1877.5" "1741.8" "2065.8" "2037.4" "1219.6" "" "" "" "" "" "" "" "" "" "" "917.7" "869.3" "1055.7" "707.9" "846.4" "1044.4" "1025.1" "1127.6" "1142.9" "1219.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8110306690791428834" "False" "High" "IsMasterProtein" "P29218" "Inositol monophosphatase 1 OS=Homo sapiens OX=9606 GN=IMPA1 PE=1 SV=1" "0.000" "False" "32.091" "22" "5" "9" "5" "277" "30.2" "5.26" "24.37" "5" "other metabolic processes;signal transduction" "cytosol;other cell component" "other molecular function" "Pf00459" "3612" "ENSG00000133731" "IMPA1" "B2R733; B4DLN3; B7Z6Q4; J3KQT7; P29218; Q9UK71" "" "Synthesis of IP2, IP, and Ins in the cytosol" "1" "0" "0.951" "1.011" "1.039" "1.033" "1.024" "1.100" "1.013" "1.006" "0.565" "804.8" "765.2" "813.9" "835.8" "831.0" "823.8" "884.9" "815.4" "809.6" "454.4" "" "" "" "" "" "" "" "" "" "" "426.1" "424.2" "466.1" "384.9" "449.6" "458.2" "520.8" "445.1" "454.2" "454.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1873273852874603797" "False" "High" "IsMasterProtein" "Q709C8" "Intermembrane lipid transfer protein VPS13C OS=Homo sapiens OX=9606 GN=VPS13C PE=1 SV=1" "0.000" "False" "32.002" "2" "9" "9" "9" "3753" "422.1" "6.83" "20.87" "9" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf06650, Pf09333, Pf12624, Pf16908, Pf16909, Pf16910, Pf21679" "54832" "ENSG00000129003" "VPS13C" "hsa:54832; Q6ISR4; Q702P2; Q702P3; Q709C8; Q709C9; Q9NXN8; Q9P2C6" "" "" "0" "0" "1.053" "1.001" "1.097" "1.149" "1.043" "1.217" "1.187" "1.202" "1.073" "706.0" "743.1" "706.7" "774.6" "811.5" "736.7" "859.5" "838.2" "848.8" "757.4" "" "" "" "" "" "" "" "" "" "" "373.8" "412.0" "404.7" "356.7" "439.0" "409.8" "505.9" "457.5" "476.2" "757.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "454806171855366482" "False" "High" "IsMasterProtein" "P40939" "Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=HADHA PE=1 SV=2" "0.000" "False" "31.958" "11" "9" "11" "9" "763" "82.9" "9.04" "30.93" "9" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00378, Pf00725, Pf02737" "3030" "ENSG00000084754" "HADHA" "B2R7L4; B4DYP2; hsa:3030; P40939; Q16679; Q53T69; Q53TA2; Q96GT7; Q9UQC5" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; Valproic acid pathway; Mitochondrial fatty acid oxidation disorders; Sudden infant death syndrome (SIDS) susceptibility pathways" "Acyl chain remodeling of CL; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA" "13" "0" "0.935" "0.951" "1.078" "0.914" "0.975" "0.979" "0.325" "0.959" "6.788" "437.7" "409.2" "416.2" "472.0" "399.8" "426.6" "428.6" "142.2" "419.8" "2971.0" "" "" "" "" "" "" "" "" "" "" "231.8" "226.9" "238.4" "217.4" "216.3" "237.3" "252.2" "77.6" "235.5" "2971.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7544877575899964257" "False" "High" "IsMasterProtein" "Q96C57" "Protein CUSTOS OS=Homo sapiens OX=9606 GN=CUSTOS PE=1 SV=2" "0.000" "False" "31.908" "31" "6" "10" "6" "262" "28.2" "9.42" "34.70" "6" "cell-cell signaling;signal transduction;other biological processes" "nucleus" "" "" "64897" "ENSG00000157895" "CUSTOS" "Q53HF0; Q96C57; Q9H9Z7" "" "" "0" "0" "1.080" "1.102" "1.178" "1.117" "0.995" "1.125" "1.151" "0.978" "0.390" "608.1" "656.5" "670.0" "716.3" "679.1" "605.3" "684.0" "700.1" "594.9" "237.2" "" "" "" "" "" "" "" "" "" "" "322.0" "364.0" "383.7" "329.9" "367.4" "336.7" "402.6" "382.1" "333.7" "237.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-915816600694735360" "False" "High" "IsMasterProtein" "O14980" "Exportin-1 OS=Homo sapiens OX=9606 GN=XPO1 PE=1 SV=1" "0.000" "False" "31.880" "9" "9" "10" "9" "1071" "123.3" "6.06" "28.83" "9" "other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03810, Pf08389, Pf08767, Pf18777, Pf18784, Pf18787" "7514" "ENSG00000082898" "XPO1" "A6NL14; A8K1K5; D6W5E2; hsa:7514; O14980; Q63HP8; Q68CP3; Q99433" "eIF5A regulation in response to inhibition of the nuclear export system; 22q11.2 copy number variation syndrome" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; MAPK6/MAPK4 signaling; NPAS4 regulates expression of target genes; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Heme signaling; Deactivation of the beta-catenin transactivating complex; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Downregulation of TGF-beta receptor signaling; HuR (ELAVL1) binds and stabilizes mRNA; Cyclin A/B1/B2 associated events during G2/M transition; Maturation of hRSV A proteins" "19" "0" "1.097" "1.058" "1.078" "1.119" "1.080" "1.219" "0.529" "1.033" "8.205" "227.4" "249.4" "240.6" "245.2" "254.5" "245.7" "277.3" "120.3" "234.9" "1866.2" "" "" "" "" "" "" "" "" "" "" "120.4" "138.3" "137.8" "112.9" "137.7" "136.7" "163.2" "65.6" "131.8" "1866.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6460139479284416051" "False" "High" "IsMasterProtein" "Q86UK7" "E3 ubiquitin-protein ligase ZNF598 OS=Homo sapiens OX=9606 GN=ZNF598 PE=1 SV=1" "0.000" "False" "31.847" "9" "8" "8" "8" "904" "98.6" "8.40" "25.00" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "translation activity;other molecular function" "" "90850" "" "ZNF598" "hsa:90850; Q86UK7; Q8IW49; Q8N3D9; Q96FG3; Q9H7J3" "" "" "0" "0" "1.028" "0.989" "1.241" "1.110" "1.102" "1.286" "1.222" "1.169" "1.885" "426.8" "438.8" "422.0" "529.6" "473.9" "470.5" "548.9" "521.5" "499.0" "804.6" "" "" "" "" "" "" "" "" "" "" "226.0" "243.3" "241.7" "243.9" "256.4" "261.7" "323.0" "284.7" "279.9" "804.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5939378456610215612" "False" "High" "IsMasterProtein" "O95819" "Mitogen-activated protein kinase kinase kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP4K4 PE=1 SV=2" "0.000" "False" "31.825" "7" "9" "9" "9" "1239" "142.0" "7.46" "27.22" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00780" "9448" "ENSG00000071054" "MAP4K4" "E7ESS2; hsa:9448; O75172; O95819; Q9NST7" "MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Insulin signaling; Pleural mesothelioma" "Oxidative Stress Induced Senescence" "7" "0" "1.077" "1.037" "1.036" "0.985" "1.022" "0.956" "0.822" "0.965" "1.132" "482.2" "519.4" "500.1" "499.3" "475.2" "492.8" "461.1" "396.2" "465.1" "545.6" "" "" "" "" "" "" "" "" "" "" "255.3" "288.0" "286.4" "230.0" "257.1" "274.1" "271.4" "216.3" "260.9" "545.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6062730820723703914" "False" "High" "IsMasterProtein" "P82094" "TATA element modulatory factor OS=Homo sapiens OX=9606 GN=TMF1 PE=1 SV=2" "0.000" "False" "31.795" "9" "11" "11" "11" "1093" "122.8" "4.92" "25.10" "11" "cell-cell signaling;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "Pf12325, Pf12329" "7110" "ENSG00000144747" "TMF1" "B7ZLJ2; hsa:7110; P82094; Q17R87; Q59GK0" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "1.016" "0.993" "1.007" "1.000" "0.945" "1.052" "1.100" "1.126" "0.551" "718.0" "729.7" "713.1" "722.8" "717.7" "678.4" "755.5" "789.7" "808.3" "395.5" "" "" "" "" "" "" "" "" "" "" "380.2" "404.6" "408.4" "332.9" "388.3" "377.4" "444.6" "431.1" "453.4" "395.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5940813161561783541" "False" "High" "IsMasterProtein" "Q9H078" "Mitochondrial disaggregase OS=Homo sapiens OX=9606 GN=CLPB PE=1 SV=1" "0.000" "False" "31.790" "12" "9" "11" "9" "707" "78.7" "9.01" "31.35" "9" "stress response;signal transduction;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf07724, Pf10431, Pf12796" "81570" "ENSG00000162129" "CLPB" "B4DXJ7; B4DXP7; B4DXW4; E7EWN6; F8W7P6; hsa:81570; Q8ND11; Q9H078; Q9H8Y0" "" "" "0" "0" "1.027" "0.966" "1.100" "1.065" "1.084" "0.964" "0.923" "0.923" "0.599" "806.4" "827.9" "778.6" "887.0" "858.7" "873.8" "777.3" "744.4" "744.0" "483.1" "" "" "" "" "" "" "" "" "" "" "427.0" "459.0" "445.9" "408.5" "464.6" "486.1" "457.4" "406.4" "417.4" "483.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2454508349601298395" "False" "High" "IsMasterProtein" "Q99447" "Ethanolamine-phosphate cytidylyltransferase OS=Homo sapiens OX=9606 GN=PCYT2 PE=1 SV=1" "0.000" "False" "31.749" "20" "8" "14" "8" "389" "43.8" "6.92" "37.38" "8" "other metabolic processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf01467" "5833" "ENSG00000185813" "PCYT2" "B7Z7A5; B7ZAS0; F5H8B1; hsa:5833; Q6IBM3; Q96G08; Q99447" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids" "Synthesis of PE" "5" "0" "0.976" "0.961" "1.001" "1.027" "0.950" "0.990" "0.934" "0.899" "0.591" "924.3" "901.8" "888.3" "924.9" "949.6" "878.1" "914.7" "863.6" "831.1" "546.3" "" "" "" "" "" "" "" "" "" "" "489.4" "500.0" "508.7" "425.9" "513.8" "488.4" "538.3" "471.4" "466.2" "546.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7590147556392166876" "False" "High" "IsMasterProtein" "P07384" "Calpain-1 catalytic subunit OS=Homo sapiens OX=9606 GN=CAPN1 PE=1 SV=1" "0.000" "False" "31.746" "11" "9" "11" "9" "714" "81.8" "5.67" "32.40" "9" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00648, Pf01067, Pf13833" "823" "ENSG00000014216" "CAPN1" "P07384; Q2TTR0; Q6DHV4" "Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Formation of the cornified envelope; Degradation of the extracellular matrix; Neutrophil degranulation; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "7" "0" "0.983" "0.977" "0.932" "0.990" "0.978" "0.918" "0.960" "0.885" "0.596" "760.2" "747.2" "742.8" "708.4" "752.8" "743.2" "698.0" "730.0" "672.6" "452.9" "" "" "" "" "" "" "" "" "" "" "402.5" "414.3" "425.4" "326.2" "407.3" "413.4" "410.8" "398.5" "377.3" "452.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1422761924457517511" "False" "High" "IsMasterProtein" "A3KN83" "Protein strawberry notch homolog 1 OS=Homo sapiens OX=9606 GN=SBNO1 PE=1 SV=1" "0.000" "False" "31.725" "6" "8" "9" "8" "1393" "154.2" "7.88" "26.23" "8" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13871, Pf13872" "55206" "ENSG00000139697" "SBNO1" "A3KN83; Q05C06; Q3ZTS3; Q9H3T8; Q9NVB2" "" "" "0" "0" "0.989" "1.050" "0.947" "1.004" "1.087" "0.936" "0.925" "1.010" "1.194" "809.5" "801.0" "849.9" "766.5" "813.0" "879.9" "757.5" "748.8" "817.7" "966.5" "" "" "" "" "" "" "" "" "" "" "428.7" "444.1" "486.7" "353.0" "439.9" "489.4" "445.8" "408.7" "458.7" "966.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-700006474042265009" "False" "High" "IsMasterProtein" "Q7Z739" "YTH domain-containing family protein 3 OS=Homo sapiens OX=9606 GN=YTHDF3 PE=1 SV=1" "0.000" "False" "31.671" "14" "8" "12" "5" "585" "63.8" "9.04" "38.03" "8" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf04146" "253943" "ENSG00000185728" "YTHDF3" "B3KXL4; hsa:253943; Q63Z37; Q659A3; Q7Z739" "" "" "0" "3" "0.980" "1.034" "1.032" "0.981" "1.040" "1.005" "1.024" "0.977" "0.987" "1019.6" "998.8" "1054.4" "1052.0" "999.8" "1060.4" "1024.2" "1044.4" "995.8" "1006.6" "" "" "" "" "" "" "" "" "" "" "539.9" "553.8" "603.8" "484.5" "540.9" "589.8" "602.8" "570.1" "558.6" "1006.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-93138434393619496" "False" "High" "IsMasterProtein" "Q9NTI5" "Sister chromatid cohesion protein PDS5 homolog B OS=Homo sapiens OX=9606 GN=PDS5B PE=1 SV=1" "0.000" "False" "31.652" "6" "9" "9" "8" "1447" "164.6" "8.47" "25.79" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf20168" "23047" "ENSG00000083642" "PDS5B" "hsa:23047; Q5R3S3; Q5W0K8; Q6NSC3; Q8IXT6; Q9H5N8; Q9NTI5; Q9Y2I5; Q9Y451" "Cohesin complex - Cornelia de Lange syndrome; 10q22q23 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "6" "1" "1.045" "1.033" "1.058" "1.073" "1.071" "1.000" "0.777" "1.012" "3.800" "731.2" "764.2" "755.2" "773.5" "784.3" "782.9" "731.2" "567.9" "739.7" "2778.5" "" "" "" "" "" "" "" "" "" "" "387.2" "423.7" "432.5" "356.2" "424.3" "435.5" "430.3" "310.0" "415.0" "2778.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1756895692335459560" "False" "High" "IsMasterProtein" "O95865" "Putative hydrolase DDAH2 OS=Homo sapiens OX=9606 GN=DDAH2 PE=1 SV=1" "0.000" "False" "31.645" "32" "7" "9" "7" "285" "29.6" "6.01" "22.08" "7" "other metabolic processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "" "23564" "ENSG00000206395; ENSG00000213722; ENSG00000225635; ENSG00000226634; ENSG00000227317; ENSG00000228128; ENSG00000233076" "DDAH2" "A2BEZ7; hsa:23564; O95865" "Nitric oxide metabolism in cystic fibrosis" "" "1" "0" "0.955" "0.920" "0.889" "0.949" "1.025" "0.969" "0.937" "0.883" "0.602" "335.4" "320.4" "308.5" "298.2" "318.4" "343.8" "324.8" "314.3" "296.1" "201.8" "" "" "" "" "" "" "" "" "" "" "177.6" "177.6" "176.7" "137.3" "172.2" "191.2" "191.2" "171.6" "166.1" "201.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8454971752249747449" "False" "High" "IsMasterProtein" "Q9BSD7" "Cancer-related nucleoside-triphosphatase OS=Homo sapiens OX=9606 GN=NTPCR PE=1 SV=1" "0.000" "False" "31.623" "31" "5" "8" "5" "190" "20.7" "9.54" "23.02" "5" "" "" "other molecular function" "Pf03266" "84284" "ENSG00000135778" "NTPCR" "hsa:84284; Q9BSD7" "" "" "0" "0" "1.005" "0.889" "1.000" "0.995" "0.977" "0.844" "0.915" "0.804" "0.589" "433.6" "435.9" "385.6" "433.6" "431.6" "423.7" "366.2" "397.0" "348.7" "255.5" "" "" "" "" "" "" "" "" "" "" "229.6" "241.7" "220.8" "199.7" "233.5" "235.7" "215.5" "216.7" "195.6" "255.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6712994512663593747" "False" "High" "IsMasterProtein" "Q4G0N4" "NAD kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=NADK2 PE=1 SV=2" "0.000" "False" "31.573" "15" "7" "10" "7" "442" "49.4" "8.18" "28.77" "7" "other metabolic processes" "mitochondrion" "kinase activity;other molecular function" "Pf01513" "133686" "ENSG00000152620" "NADK2" "B5MC93; hsa:133686; Q4G0N4; Q6UTX5; Q96NM0" "" "Mitochondrial protein degradation; Nicotinate metabolism" "2" "0" "1.002" "0.910" "0.935" "0.980" "1.055" "0.944" "0.986" "0.970" "0.627" "783.2" "784.7" "712.3" "732.2" "767.6" "826.1" "739.3" "772.6" "760.0" "491.1" "" "" "" "" "" "" "" "" "" "" "414.7" "435.1" "408.0" "337.2" "415.3" "459.5" "435.1" "421.7" "426.3" "491.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2637590011477773491" "False" "High" "IsMasterProtein" "P46459" "Vesicle-fusing ATPase OS=Homo sapiens OX=9606 GN=NSF PE=1 SV=3" "0.000" "False" "31.562" "12" "9" "10" "9" "744" "82.5" "6.95" "21.26" "9" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00004, Pf02359, Pf02933, Pf17862" "4905" "ENSG00000073969; ENSG00000276262; ENSG00000278174" "NSF" "A8K2D9; B4DFA2; P46459; Q8N6D7; Q9UKZ2" "Synaptic vesicle pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Vasopressin-regulated water reabsorption" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport; Retrograde transport at the Trans-Golgi-Network; Trafficking of GluR2-containing AMPA receptors" "9" "0" "1.044" "1.006" "1.073" "1.071" "1.099" "0.995" "0.923" "0.992" "1.281" "777.9" "811.9" "782.6" "834.4" "833.3" "854.6" "774.0" "718.0" "771.4" "996.8" "" "" "" "" "" "" "" "" "" "" "411.9" "450.1" "448.2" "384.3" "450.8" "475.3" "455.5" "391.9" "432.8" "996.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7172207260123364247" "False" "High" "IsMasterProtein" "P11172" "Uridine 5'-monophosphate synthase OS=Homo sapiens OX=9606 GN=UMPS PE=1 SV=1" "0.000" "False" "31.541" "18" "10" "17" "10" "480" "52.2" "7.24" "48.08" "10" "other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00156, Pf00215" "7372" "ENSG00000114491" "UMPS" "B5LY68; B5LY72; hsa:7372; O00758; O00759; O00760; P11172; Q16862; Q9H3Q2; Q9UG49" "Fluoropyrimidine activity; Pyrimidine metabolism" "Pyrimidine biosynthesis" "3" "0" "1.004" "0.984" "1.023" "1.029" "1.060" "1.008" "1.010" "0.973" "0.646" "1889.2" "1896.8" "1858.7" "1932.1" "1943.9" "2002.7" "1904.4" "1907.9" "1838.8" "1221.3" "" "" "" "" "" "" "" "" "" "" "1000.3" "1051.7" "1064.5" "889.8" "1051.7" "1114.0" "1120.8" "1041.5" "1031.5" "1221.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2537127350626285919" "False" "High" "IsMasterProtein" "P49959" "Double-strand break repair protein MRE11 OS=Homo sapiens OX=9606 GN=MRE11 PE=1 SV=3" "0.000" "False" "31.525" "13" "10" "13" "10" "708" "80.5" "5.90" "30.53" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00149, Pf04152" "4361" "ENSG00000020922" "MRE11" "B3KTC7; hsa:4361; O43475; P49959" "miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; Breast cancer pathway; Joubert syndrome; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Neurogenesis regulation in the olfactory epithelium; DNA damage response" "Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Cytosolic sensors of pathogen-associated DNA ; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks; IRF3-mediated induction of type I IFN" "31" "0" "1.012" "1.037" "1.040" "1.069" "1.013" "1.137" "1.037" "1.014" "1.673" "1066.4" "1079.1" "1105.8" "1108.8" "1140.4" "1080.5" "1212.8" "1106.3" "1081.3" "1784.3" "" "" "" "" "" "" "" "" "" "" "564.7" "598.3" "633.3" "510.6" "617.0" "601.0" "713.8" "603.9" "606.6" "1784.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "980650416735823729" "False" "High" "IsMasterProtein" "Q9UHD1" "Cysteine and histidine-rich domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CHORDC1 PE=1 SV=2" "0.000" "False" "31.516" "21" "8" "11" "8" "332" "37.5" "7.87" "38.41" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "" "other molecular function" "Pf04968, Pf04969" "26973" "ENSG00000110172; ENSG00000285023" "CHORDC1" "B2R6P8; hsa:26973; Q6IN49; Q8WVL9; Q9H3D6; Q9UHD1" "" "" "0" "0" "1.012" "0.972" "0.949" "0.904" "0.938" "0.864" "0.933" "0.953" "0.678" "3471.7" "3513.9" "3375.2" "3295.2" "3137.3" "3255.9" "3000.4" "3238.7" "3309.8" "2352.7" "" "" "" "" "" "" "" "" "" "" "1838.2" "1948.2" "1933.0" "1517.6" "1697.4" "1811.1" "1765.9" "1767.9" "1856.7" "2352.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3394918450034897638" "False" "High" "IsMasterProtein" "P55884" "Eukaryotic translation initiation factor 3 subunit B OS=Homo sapiens OX=9606 GN=EIF3B PE=1 SV=3" "0.000" "False" "31.496" "13" "10" "15" "10" "814" "92.4" "5.00" "25.17" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08662" "8662" "ENSG00000106263" "EIF3B" "A4D208; hsa:8662; P55884; Q2NL77; Q9UMF9" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "0" "0.946" "0.986" "1.076" "0.961" "1.096" "0.921" "0.856" "0.996" "2.497" "388.3" "367.5" "382.9" "417.6" "373.1" "425.5" "357.7" "332.2" "386.6" "969.7" "" "" "" "" "" "" "" "" "" "" "205.6" "203.7" "219.3" "192.3" "201.9" "236.7" "210.5" "181.3" "216.9" "969.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8303204193391828869" "False" "High" "IsMasterProtein" "Q8WUI4" "Histone deacetylase 7 OS=Homo sapiens OX=9606 GN=HDAC7 PE=1 SV=2" "0.000" "False" "31.476" "9" "8" "8" "8" "952" "102.9" "7.58" "25.69" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00850" "51564" "ENSG00000061273" "HDAC7" "B3KY08; B4DWI0; B4E0Q5; hsa:51564; Q6P1W9; Q6W9G7; Q7Z4K2; Q7Z5I1; Q8WUI4; Q96K01; Q9BR73; Q9H7L0; Q9NW41; Q9NWA9; Q9NYK9; Q9UFU7" "MicroRNAs in cardiomyocyte hypertrophy; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; Gastrin signaling pathway" "Regulation of PTEN gene transcription; SUMOylation of DNA damage response and repair proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway" "13" "0" "1.024" "1.013" "1.163" "1.136" "1.257" "1.259" "1.068" "1.176" "0.905" "389.9" "399.2" "395.0" "453.6" "442.8" "490.3" "490.8" "416.4" "458.4" "353.0" "" "" "" "" "" "" "" "" "" "" "206.5" "221.3" "226.2" "208.9" "239.6" "272.7" "288.9" "227.3" "257.2" "353.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7380698507310522757" "False" "High" "IsMasterProtein" "P41227" "N-alpha-acetyltransferase 10 OS=Homo sapiens OX=9606 GN=NAA10 PE=1 SV=1" "0.000" "False" "31.455" "33" "8" "14" "8" "235" "26.4" "5.64" "34.68" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "8260" "ENSG00000102030" "NAA10" "A6NM98; hsa:8260; P41227" "" "" "0" "0" "0.933" "1.018" "0.979" "1.009" "0.985" "0.889" "1.016" "0.947" "0.585" "1150.1" "1073.5" "1171.0" "1125.8" "1161.0" "1132.9" "1022.1" "1169.0" "1089.7" "672.6" "" "" "" "" "" "" "" "" "" "" "609.0" "595.2" "670.6" "518.4" "628.1" "630.2" "601.5" "638.1" "611.3" "672.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5459643991948160099" "False" "High" "IsMasterProtein" "Q9NWH9" "SAFB-like transcription modulator OS=Homo sapiens OX=9606 GN=SLTM PE=1 SV=2" "0.000" "False" "31.389" "9" "8" "9" "8" "1034" "117.1" "7.87" "21.70" "8" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf02037" "79811" "ENSG00000137776" "SLTM" "A8K5V8; B2RTX3; hsa:79811; Q2VPK7; Q52MB3; Q658J7; Q6ZNF2; Q86TK6; Q9H7C3; Q9H8U9; Q9NWH9" "" "" "0" "0" "0.980" "0.990" "0.931" "1.026" "0.992" "1.053" "1.188" "1.278" "0.616" "581.7" "570.2" "576.2" "541.6" "596.8" "576.9" "612.5" "690.9" "743.4" "358.3" "" "" "" "" "" "" "" "" "" "" "308.0" "316.2" "330.0" "249.4" "322.9" "320.9" "360.5" "377.1" "417.0" "358.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4287058177622287432" "False" "High" "IsMasterProtein" "O95757" "Heat shock 70 kDa protein 4L OS=Homo sapiens OX=9606 GN=HSPA4L PE=1 SV=3" "0.000" "False" "31.362" "12" "10" "12" "9" "839" "94.5" "5.88" "22.04" "10" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf00012" "22824" "ENSG00000164070" "HSPA4L" "A2ICT2; hsa:22824; O95757; Q4W5M5; Q8IWA2" "" "Regulation of HSF1-mediated heat shock response" "1" "1" "1.079" "1.029" "1.149" "1.119" "1.083" "1.151" "1.118" "1.240" "2.190" "759.1" "819.0" "781.3" "872.2" "849.4" "821.7" "873.7" "848.9" "941.3" "1662.7" "" "" "" "" "" "" "" "" "" "" "401.9" "454.1" "447.4" "401.7" "459.5" "457.1" "514.2" "463.4" "528.1" "1662.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1516272036315922492" "False" "High" "IsMasterProtein" "Q15637" "Splicing factor 1 OS=Homo sapiens OX=9606 GN=SF1 PE=1 SV=4" "0.000" "False" "31.324" "10" "6" "11" "6" "639" "68.3" "8.98" "32.81" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00098, Pf16275" "7536" "ENSG00000168066" "SF1" "B7Z1Q1; C9JJE2; hsa:7536; Q14818; Q14819; Q15637; Q15913; Q8IY00; Q92744; Q92745; Q969H7; Q9BW01; Q9UEI0" "" "mRNA Splicing - Major Pathway" "1" "0" "1.032" "1.090" "1.082" "1.027" "1.001" "1.010" "1.085" "0.989" "0.623" "914.3" "943.5" "996.6" "989.1" "939.2" "915.1" "923.5" "992.0" "904.0" "570.0" "" "" "" "" "" "" "" "" "" "" "484.1" "523.1" "570.7" "455.5" "508.2" "509.0" "543.5" "541.5" "507.1" "570.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7652533075202528091" "False" "High" "IsMasterProtein" "Q92734" "Protein TFG OS=Homo sapiens OX=9606 GN=TFG PE=1 SV=2" "0.000" "False" "31.320" "26" "8" "10" "8" "400" "43.4" "5.10" "30.69" "8" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00564" "10342" "ENSG00000114354" "TFG" "D3DN49; G5E9V1; hsa:10342; K0J5S8; K0J6K2; Q15656; Q92734; Q969I2" "" "Signaling by ALK fusions and activated point mutants; COPII-mediated vesicle transport" "2" "0" "0.937" "1.035" "1.114" "0.866" "0.838" "0.911" "0.995" "0.862" "0.423" "1264.1" "1184.3" "1308.7" "1408.7" "1095.0" "1059.5" "1151.9" "1258.1" "1089.5" "534.2" "" "" "" "" "" "" "" "" "" "" "669.3" "656.6" "749.5" "648.8" "592.4" "589.4" "677.9" "686.8" "611.2" "534.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1231047339708811007" "False" "High" "IsMasterProtein" "O00203" "AP-3 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP3B1 PE=1 SV=3" "0.000" "False" "31.258" "8" "9" "11" "9" "1094" "121.2" "6.04" "31.71" "9" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf14796, Pf14797" "8546" "ENSG00000132842" "AP3B1" "E5RJ68; hsa:8546; O00203; O00580; Q7Z393; Q9HD66" "" "Golgi Associated Vesicle Biogenesis; Signaling by BRAF and RAF1 fusions" "2" "0" "1.007" "0.939" "1.028" "0.993" "0.948" "0.887" "0.711" "0.881" "2.344" "902.9" "909.2" "847.7" "927.9" "896.9" "856.4" "800.5" "641.7" "795.7" "2116.0" "" "" "" "" "" "" "" "" "" "" "478.1" "504.1" "485.5" "427.3" "485.2" "476.4" "471.1" "350.3" "446.4" "2116.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8386147216843783893" "False" "High" "IsMasterProtein" "Q9NUU7" "ATP-dependent RNA helicase DDX19A OS=Homo sapiens OX=9606 GN=DDX19A PE=1 SV=1" "0.000" "False" "31.233" "16" "7" "10" "7" "478" "53.9" "6.58" "29.38" "7" "other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "55308" "ENSG00000168872" "DDX19A" "B2RPL0; B4DRZ7; hsa:55308; Q53FM0; Q9NUU7" "" "" "0" "0" "1.138" "1.198" "1.117" "0.966" "1.002" "0.882" "0.902" "0.919" "2.166" "456.3" "519.2" "546.8" "509.6" "440.8" "457.2" "402.3" "411.8" "419.5" "988.4" "" "" "" "" "" "" "" "" "" "" "241.6" "287.9" "313.2" "234.7" "238.5" "254.3" "236.8" "224.8" "235.3" "988.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3405025144750981774" "False" "High" "IsMasterProtein" "P52732" "Kinesin-like protein KIF11 OS=Homo sapiens OX=9606 GN=KIF11 PE=1 SV=2" "0.000" "False" "31.199" "6" "6" "8" "6" "1056" "119.1" "5.64" "20.69" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf13931" "3832" "ENSG00000138160" "KIF11" "A0AV49; B2RMV3; hsa:3832; P52732; Q15716; Q5VWX0" "" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins" "3" "0" "0.943" "1.066" "1.174" "1.156" "1.088" "1.161" "0.918" "1.107" "2.971" "333.7" "314.6" "355.6" "391.7" "385.7" "363.1" "387.4" "306.4" "369.6" "991.5" "" "" "" "" "" "" "" "" "" "" "176.7" "174.4" "203.7" "180.4" "208.7" "202.0" "228.0" "167.3" "207.3" "991.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6424990256346318104" "False" "High" "IsMasterProtein" "P04792" "Heat shock protein beta-1 OS=Homo sapiens OX=9606 GN=HSPB1 PE=1 SV=2" "0.000" "False" "31.148" "30" "6" "7" "6" "205" "22.8" "6.40" "21.45" "6" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00011" "3315" "ENSG00000106211" "HSPB1" "B2R4N8; hsa:3315; P04792; Q6FI47; Q96C20; Q96EI7; Q9UC31; Q9UC34; Q9UC35; Q9UC36" "Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling; p38 MAPK signaling pathway; Extracellular vesicles in the crosstalk of cardiac cells; Ferroptosis; IL-18 signaling pathway; Intracellular trafficking proteins involved in CMT neuropathy; GDNF signaling; Macrophage-stimulating protein (MSP) signaling network map; 7q11.23 distal copy number variation; HDAC6 interactions in the central nervous system" "AUF1 (hnRNP D0) binds and destabilizes mRNA; MAPK6/MAPK4 signaling; Extra-nuclear estrogen signaling; VEGFA-VEGFR2 Pathway" "18" "0" "0.957" "0.990" "1.023" "1.071" "0.953" "0.973" "0.774" "0.942" "3.611" "817.2" "781.7" "809.2" "835.8" "875.1" "779.0" "795.3" "632.9" "769.9" "2951.1" "" "" "" "" "" "" "" "" "" "" "432.7" "433.4" "463.4" "384.9" "473.5" "433.3" "468.0" "345.4" "431.9" "2951.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-985965989456980911" "False" "High" "IsMasterProtein" "Q8TEQ6" "Gem-associated protein 5 OS=Homo sapiens OX=9606 GN=GEMIN5 PE=1 SV=3" "0.000" "False" "31.144" "6" "8" "10" "8" "1508" "168.5" "6.62" "24.69" "8" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf00400, Pf12894, Pf21720" "25929" "ENSG00000082516" "GEMIN5" "Q14CV0; Q8TEQ6; Q8WWV4; Q969W4; Q9H9K3; Q9UFI5" "" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "2" "0" "0.971" "1.000" "1.014" "0.985" "1.056" "1.151" "1.090" "1.123" "2.683" "528.1" "513.0" "528.4" "535.5" "520.4" "557.4" "607.6" "575.8" "593.2" "1416.9" "" "" "" "" "" "" "" "" "" "" "279.6" "284.4" "302.6" "246.6" "281.5" "310.1" "357.6" "314.3" "332.8" "1416.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4191413839330820481" "False" "High" "IsMasterProtein" "O14979" "Heterogeneous nuclear ribonucleoprotein D-like OS=Homo sapiens OX=9606 GN=HNRNPDL PE=1 SV=3" "0.000" "False" "31.111" "23" "10" "23" "8" "420" "46.4" "9.57" "54.69" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf00076" "9987" "ENSG00000152795" "HNRNPDL" "hsa:9987; O14979; Q6SPF2; Q7KZ74; Q7KZ75; Q96IM0; Q96S43" "" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "1" "0" "0.988" "1.032" "1.076" "0.983" "0.950" "0.998" "0.982" "0.959" "0.688" "773.0" "763.4" "797.6" "831.5" "759.7" "734.4" "771.3" "759.4" "741.6" "531.7" "" "" "" "" "" "" "" "" "" "" "409.3" "423.2" "456.8" "383.0" "411.0" "408.5" "453.9" "414.5" "416.0" "531.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6612546022737726869" "False" "High" "IsMasterProtein" "P80303" "Nucleobindin-2 OS=Homo sapiens OX=9606 GN=NUCB2 PE=1 SV=3" "0.000" "False" "31.092" "24" "9" "11" "9" "420" "50.2" "5.12" "30.52" "9" "signal transduction" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf13499" "4925" "ENSG00000070081" "NUCB2" "A8K642; D3DQX5; hsa:4925; P80303; Q8NFT5; V9HW75" "" "" "0" "0" "0.973" "1.104" "0.995" "0.954" "1.021" "1.116" "1.206" "1.152" "0.723" "808.6" "786.4" "893.0" "804.3" "771.3" "825.8" "902.5" "975.3" "931.7" "585.0" "" "" "" "" "" "" "" "" "" "" "428.2" "436.0" "511.4" "370.4" "417.3" "459.4" "531.1" "532.4" "522.7" "585.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1141032543915842811" "False" "High" "IsMasterProtein" "Q13011" "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial OS=Homo sapiens OX=9606 GN=ECH1 PE=1 SV=2" "0.000" "False" "31.011" "17" "5" "11" "5" "328" "35.8" "8.00" "36.48" "5" "other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf00378" "1891" "ENSG00000104823; ENSG00000282853" "ECH1" "A8K745; hsa:1891; Q13011; Q8WVX0; Q96EZ9" "Fatty acid biosynthesis; IL-18 signaling pathway" "Mitochondrial protein degradation; Peroxisomal protein import" "4" "0" "0.956" "0.929" "0.839" "0.866" "0.902" "0.953" "0.866" "0.935" "0.502" "1144.2" "1093.3" "1062.4" "960.0" "990.7" "1031.7" "1090.9" "990.6" "1070.2" "574.7" "" "" "" "" "" "" "" "" "" "" "605.8" "606.2" "608.4" "442.1" "536.0" "573.9" "642.0" "540.7" "600.3" "574.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8788439396421035672" "False" "High" "IsMasterProtein" "Q92621" "Nuclear pore complex protein Nup205 OS=Homo sapiens OX=9606 GN=NUP205 PE=1 SV=3" "0.000" "False" "31.010" "4" "8" "9" "8" "2012" "227.8" "6.19" "26.99" "8" "cell organization and biogenesis;transport" "other membranes;cytosol;nucleus" "other molecular function" "Pf11894" "23165" "ENSG00000155561" "NUP205" "A6H8X3; hsa:23165; Q86YC1; Q92621" "" "SUMOylation of DNA replication proteins; HCMV Early Events; Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "29" "0" "1.102" "0.968" "1.095" "1.027" "0.988" "0.922" "0.800" "1.003" "1.791" "519.6" "572.5" "503.1" "569.0" "533.8" "513.1" "478.9" "415.6" "521.3" "930.6" "" "" "" "" "" "" "" "" "" "" "275.1" "317.4" "288.1" "262.0" "288.8" "285.4" "281.9" "226.9" "292.4" "930.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-885056090803738498" "False" "High" "IsMasterProtein" "P47897" "Glutamine--tRNA ligase OS=Homo sapiens OX=9606 GN=QARS1 PE=1 SV=1" "0.000" "False" "30.993" "10" "7" "9" "7" "775" "87.7" "7.15" "27.28" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf00749, Pf03950, Pf04557, Pf04558, Pf20974" "5859" "ENSG00000172053" "QARS1" "B4DWJ2; hsa:5859; P47897" "" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation" "3" "0" "1.067" "0.964" "1.035" "1.121" "1.137" "1.024" "0.338" "0.902" "8.085" "338.5" "361.2" "326.2" "350.5" "379.5" "384.8" "346.6" "114.5" "305.2" "2736.9" "" "" "" "" "" "" "" "" "" "" "179.3" "200.3" "186.8" "161.4" "205.3" "214.1" "204.0" "62.5" "171.2" "2736.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6086246065885053041" "False" "High" "IsMasterProtein" "Cont_P02533" "Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4" "0.000" "True" "30.984" "19" "10" "18" "7" "472" "51.5" "5.16" "42.54" "10" "cell organization and biogenesis;other biological processes" "plasma membrane;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00038" "3861" "ENSG00000186847" "KRT14" "hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4" "Corticotropin-releasing hormone signaling pathway" "Formation of the cornified envelope; Type I hemidesmosome assembly" "4" "0" "1.880" "0.642" "0.462" "0.526" "0.721" "1.008" "0.628" "0.417" "0.616" "656.3" "1233.7" "421.6" "303.0" "345.0" "473.0" "661.5" "412.1" "273.4" "404.0" "" "" "" "" "" "" "" "" "" "" "347.5" "684.0" "241.5" "139.5" "186.7" "263.1" "389.3" "224.9" "153.4" "404.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7260357318160893257" "False" "High" "IsMasterProtein" "O75439" "Mitochondrial-processing peptidase subunit beta OS=Homo sapiens OX=9606 GN=PMPCB PE=1 SV=2" "0.000" "False" "30.959" "15" "7" "8" "6" "489" "54.3" "6.83" "30.90" "7" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion" "other molecular function" "Pf00675, Pf05193" "9512" "ENSG00000105819" "PMPCB" "hsa:9512; O60416; O75439; Q96FV4" "" "Mitochondrial protein import; Processing of SMDT1" "2" "1" "0.966" "0.994" "0.952" "0.966" "0.948" "0.888" "0.894" "0.847" "0.767" "1143.8" "1104.5" "1137.5" "1089.5" "1104.4" "1084.7" "1015.4" "1022.2" "968.5" "877.7" "" "" "" "" "" "" "" "" "" "" "605.7" "612.4" "651.5" "501.7" "597.5" "603.4" "597.6" "558.0" "543.3" "877.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1626409123411173154" "False" "High" "IsMasterProtein" "Q99598" "Translin-associated protein X OS=Homo sapiens OX=9606 GN=TSNAX PE=1 SV=1" "0.000" "False" "30.827" "32" "9" "16" "9" "290" "33.1" "6.55" "33.10" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf01997" "7257" "ENSG00000116918" "TSNAX" "B1APC6; hsa:7257; Q99598" "" "Small interfering RNA (siRNA) biogenesis" "1" "0" "0.946" "0.991" "0.903" "0.925" "0.966" "0.900" "0.994" "0.995" "0.563" "1772.8" "1677.9" "1756.6" "1601.5" "1639.4" "1711.9" "1596.2" "1761.8" "1764.8" "998.0" "" "" "" "" "" "" "" "" "" "" "938.7" "930.3" "1006.0" "737.5" "887.0" "952.2" "939.4" "961.7" "990.0" "998.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8472410284542291541" "False" "High" "IsMasterProtein" "P61289" "Proteasome activator complex subunit 3 OS=Homo sapiens OX=9606 GN=PSME3 PE=1 SV=1" "0.000" "False" "30.825" "29" "7" "16" "7" "254" "29.5" "5.95" "44.05" "7" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02251, Pf02252" "10197" "ENSG00000131467" "PSME3" "A8K9A3; hsa:10197; O35563; P61289; P97373; Q12920; Q13172; Q9BQD9" "Proteasome degradation" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of expression of SLITs and ROBOs; ER-Phagosome pathway; Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "60" "0" "1.003" "0.973" "0.961" "0.971" "1.026" "0.906" "0.940" "0.895" "0.613" "1211.2" "1215.1" "1178.1" "1163.6" "1175.5" "1242.8" "1096.9" "1138.2" "1084.6" "742.5" "" "" "" "" "" "" "" "" "" "" "641.3" "673.7" "674.7" "535.9" "636.0" "691.3" "645.6" "621.3" "608.4" "742.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8199308046116639924" "False" "High" "IsMasterProtein" "Q29RF7" "Sister chromatid cohesion protein PDS5 homolog A OS=Homo sapiens OX=9606 GN=PDS5A PE=1 SV=1" "0.000" "False" "30.794" "7" "7" "7" "6" "1337" "150.7" "7.91" "21.60" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf20168" "23244" "ENSG00000121892" "PDS5A" "hsa:23244; Q29RF7; Q2TTR5; Q68DF7; Q8N7J4; Q8NG14; Q9Y4D4" "Cohesin complex - Cornelia de Lange syndrome; 10q22q23 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "6" "0" "1.069" "1.127" "1.160" "1.121" "1.222" "1.205" "0.743" "1.212" "5.025" "126.0" "134.7" "142.0" "146.2" "141.3" "154.0" "151.8" "93.7" "152.8" "633.3" "" "" "" "" "" "" "" "" "" "" "66.7" "74.7" "81.3" "67.3" "76.4" "85.7" "89.3" "51.1" "85.7" "633.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5541233720560719878" "False" "High" "IsMasterProtein" "O43809" "Cleavage and polyadenylation specificity factor subunit 5 OS=Homo sapiens OX=9606 GN=NUDT21 PE=1 SV=1" "0.000" "False" "30.777" "36" "8" "12" "8" "227" "26.2" "8.82" "35.82" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13869" "11051" "ENSG00000167005" "NUDT21" "hsa:11051; O43809; Q6IB85; Q6NE84" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "1.011" "1.038" "1.001" "1.030" "0.990" "1.002" "1.062" "1.018" "0.666" "2643.3" "2673.0" "2743.3" "2646.2" "2722.1" "2617.6" "2648.1" "2806.8" "2691.2" "1759.4" "" "" "" "" "" "" "" "" "" "" "1399.6" "1482.0" "1571.1" "1218.7" "1472.8" "1456.0" "1558.5" "1532.1" "1509.7" "1759.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8496601930648358283" "False" "High" "IsMasterProtein" "Q5T6F2" "Ubiquitin-associated protein 2 OS=Homo sapiens OX=9606 GN=UBAP2 PE=1 SV=1" "0.000" "False" "30.749" "8" "8" "10" "8" "1119" "117.0" "7.34" "28.95" "8" "other biological processes" "nucleus;other cell component" "" "Pf12478" "55833" "ENSG00000137073" "UBAP2" "hsa:55833; Q2M2R4; Q5JV03; Q5T6F2; Q6PK34; Q8NC94; Q9P237" "" "" "0" "0" "1.035" "1.081" "1.022" "1.044" "0.989" "1.025" "1.083" "1.011" "0.534" "760.5" "786.9" "822.0" "777.2" "794.3" "752.3" "779.7" "823.4" "768.6" "406.0" "" "" "" "" "" "" "" "" "" "" "402.7" "436.3" "470.8" "357.9" "429.7" "418.5" "458.9" "449.4" "431.2" "406.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4696526329741067639" "False" "High" "IsMasterProtein" "Q14344" "Guanine nucleotide-binding protein subunit alpha-13 OS=Homo sapiens OX=9606 GN=GNA13 PE=1 SV=2" "0.000" "False" "30.731" "25" "10" "13" "9" "377" "44.0" "8.00" "31.34" "10" "stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00503" "10672" "ENSG00000120063" "GNA13" "B2R977; B7Z7R0; F5H1G8; hsa:10672; Q14344; Q8TD70" "Thyroid stimulating hormone (TSH) signaling pathway; G protein signaling pathways; Modulators of TCR signaling and T cell activation; Regulation of actin cytoskeleton; G13 signaling pathway" "Thrombin signalling through proteinase activated receptors (PARs); Thromboxane signalling through TP receptor; G alpha (12/13) signalling events; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK" "11" "0" "0.962" "0.907" "0.961" "0.915" "0.976" "0.838" "0.879" "0.904" "0.554" "424.5" "408.2" "385.1" "408.1" "388.2" "414.1" "355.6" "373.0" "383.7" "235.1" "" "" "" "" "" "" "" "" "" "" "224.8" "226.3" "220.5" "187.9" "210.0" "230.3" "209.3" "203.6" "215.3" "235.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6289921617317730415" "False" "High" "IsMasterProtein" "Q9BWF3" "RNA-binding protein 4 OS=Homo sapiens OX=9606 GN=RBM4 PE=1 SV=1" "0.000" "False" "30.711" "24" "9" "12" "9" "364" "40.3" "7.08" "30.23" "9" "cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00098" "5936" "ENSG00000173933" "RBM4" "B3KUN0; B4E1U0; E7EQS3; hsa:5936; O02916; Q4VC48; Q6P1P2; Q8WU85; Q9BWF3" "" "Circadian Clock" "1" "0" "0.966" "0.978" "0.949" "1.106" "1.009" "0.931" "0.793" "0.895" "2.744" "627.8" "606.2" "613.9" "595.8" "694.5" "633.7" "584.6" "498.1" "561.9" "1722.9" "" "" "" "" "" "" "" "" "" "" "332.4" "336.1" "351.6" "274.4" "375.8" "352.5" "344.1" "271.9" "315.2" "1722.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2758380383998066899" "False" "High" "IsMasterProtein" "Q86V81" "THO complex subunit 4 OS=Homo sapiens OX=9606 GN=ALYREF PE=1 SV=3" "0.000" "False" "30.696" "23" "5" "15" "5" "257" "26.9" "11.15" "36.22" "5" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf13865" "10189" "" "ALYREF" "hsa:10189; O43672; Q86V81" "" "mRNA Splicing - Major Pathway; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "7" "0" "1.010" "1.015" "1.093" "1.214" "1.009" "1.162" "1.192" "1.355" "0.529" "625.8" "631.7" "635.3" "684.3" "759.8" "631.1" "727.2" "745.7" "848.0" "330.9" "" "" "" "" "" "" "" "" "" "" "331.4" "350.2" "363.9" "315.1" "411.1" "351.1" "428.0" "407.1" "475.7" "330.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "508361359361041752" "False" "High" "IsMasterProtein" "O00193" "Small acidic protein OS=Homo sapiens OX=9606 GN=SMAP PE=1 SV=1" "0.000" "False" "30.692" "40" "5" "12" "5" "183" "20.3" "4.72" "42.18" "5" "" "" "" "Pf15477" "10944" "ENSG00000110696" "SMAP" "B2RD28; hsa:10944; O00193" "" "" "0" "0" "0.835" "0.939" "0.907" "0.835" "0.800" "0.842" "0.899" "0.847" "0.379" "1848.7" "1543.1" "1735.9" "1677.2" "1544.0" "1478.9" "1556.2" "1661.1" "1565.2" "701.1" "" "" "" "" "" "" "" "" "" "" "978.9" "855.6" "994.1" "772.4" "835.4" "822.6" "915.9" "906.7" "878.1" "701.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7307754887580196146" "False" "High" "IsMasterProtein" "Q13287" "N-myc-interactor OS=Homo sapiens OX=9606 GN=NMI PE=1 SV=2" "0.000" "False" "30.682" "22" "7" "11" "7" "307" "35.0" "5.34" "31.69" "7" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf07292, Pf07334" "9111" "ENSG00000123609" "NMI" "B5BU69; hsa:9111; Q13287; Q53TI8; Q8WTW2; Q9BVE5" "IL-2 signaling pathway" "SARS-CoV-1 activates/modulates innate immune responses" "2" "0" "1.043" "1.028" "1.009" "1.015" "0.998" "1.012" "0.990" "1.002" "0.628" "1020.3" "1064.3" "1049.3" "1029.6" "1036.0" "1018.4" "1033.0" "1010.6" "1022.2" "640.8" "" "" "" "" "" "" "" "" "" "" "540.3" "590.1" "600.9" "474.2" "560.5" "566.5" "607.9" "551.6" "573.4" "640.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4807008432777767819" "False" "High" "IsMasterProtein" "Q9NTZ6" "RNA-binding protein 12 OS=Homo sapiens OX=9606 GN=RBM12 PE=1 SV=1" "0.000" "False" "30.678" "12" "10" "13" "10" "932" "97.3" "8.63" "26.45" "10" "other biological processes" "nucleus;other cell component" "" "Pf00076" "10137" "ENSG00000244462" "RBM12" "B3KRU2; E1P5R6; hsa:10137; O94865; Q8N3B1; Q9H196; Q9NTZ6" "" "" "0" "0" "1.062" "0.943" "1.087" "0.963" "0.994" "1.024" "0.628" "1.024" "5.524" "505.4" "536.6" "476.4" "549.2" "486.8" "502.5" "517.7" "317.4" "517.4" "2791.5" "" "" "" "" "" "" "" "" "" "" "267.6" "297.5" "272.9" "252.9" "263.4" "279.5" "304.7" "173.3" "290.2" "2791.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1767684544015944843" "False" "High" "IsMasterProtein" "P14678" "Small nuclear ribonucleoprotein-associated proteins B and B' OS=Homo sapiens OX=9606 GN=SNRPB PE=1 SV=2" "0.000" "False" "30.676" "36" "8" "19" "8" "240" "24.6" "11.19" "39.61" "8" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "6628" "ENSG00000125835" "SNRPB" "hsa:6628; P14678; Q15490; Q6IB35; Q9UIS5" "mRNA processing" "snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "8" "0" "1.057" "1.025" "1.111" "1.084" "1.011" "1.133" "1.093" "1.065" "0.639" "1089.1" "1151.6" "1116.7" "1210.5" "1180.8" "1101.2" "1233.8" "1190.3" "1159.8" "695.7" "" "" "" "" "" "" "" "" "" "" "576.7" "638.5" "639.5" "557.5" "638.9" "612.5" "726.2" "649.7" "650.6" "695.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5639426559288223252" "False" "High" "IsMasterProtein" "Q9UMX5" "Neudesin OS=Homo sapiens OX=9606 GN=NENF PE=1 SV=1" "0.000" "False" "30.572" "32" "5" "10" "5" "172" "18.8" "5.69" "27.01" "5" "signal transduction;other biological processes" "non-structural extracellular;other membranes;mitochondrion;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00173" "29937" "ENSG00000117691" "NENF" "A1KYQ8; hsa:29937; Q53FZ6; Q5TM90; Q9UMX5" "" "" "0" "0" "0.980" "1.054" "0.942" "1.012" "0.945" "0.951" "1.045" "0.985" "0.609" "521.5" "511.1" "549.7" "491.1" "527.7" "492.9" "495.8" "544.8" "513.7" "317.8" "" "" "" "" "" "" "" "" "" "" "276.1" "283.4" "314.8" "226.2" "285.5" "274.2" "291.8" "297.4" "288.2" "317.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4218486089971029806" "False" "High" "IsMasterProtein" "Q92608" "Dedicator of cytokinesis protein 2 OS=Homo sapiens OX=9606 GN=DOCK2 PE=1 SV=2" "0.000" "False" "30.506" "4" "8" "9" "8" "1830" "211.8" "6.87" "21.66" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf06920, Pf07653, Pf14429, Pf16172, Pf20421, Pf20422" "1794" "ENSG00000134516" "DOCK2" "hsa:1794; Q2M3I0; Q92608; Q96AK7" "Chemokine signaling pathway" "RAC1 GTPase cycle; Neutrophil degranulation; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; Factors involved in megakaryocyte development and platelet production; Nef and signal transduction" "8" "0" "0.980" "1.056" "1.049" "0.892" "1.059" "0.957" "0.500" "0.979" "9.323" "190.5" "186.6" "201.1" "199.8" "169.9" "201.7" "182.3" "95.2" "186.5" "1775.9" "" "" "" "" "" "" "" "" "" "" "100.9" "103.5" "115.2" "92.0" "91.9" "112.2" "107.3" "52.0" "104.6" "1775.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7622231560690593168" "False" "High" "IsMasterProtein" "Q13043" "Serine/threonine-protein kinase 4 OS=Homo sapiens OX=9606 GN=STK4 PE=1 SV=2" "0.000" "False" "30.481" "17" "8" "11" "4" "487" "55.6" "5.07" "25.76" "8" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf11629" "6789" "ENSG00000101109" "STK4" "B2RCR8; hsa:6789; Q13043; Q15802; Q4G156; Q5H982; Q6PD60; Q9BR32; Q9NTZ4" "MAPK signaling pathway; Ras signaling; Non-small cell lung cancer" "Signaling by Hippo" "4" "0" "1.034" "1.123" "1.059" "1.157" "1.107" "1.117" "1.148" "1.127" "0.815" "198.7" "205.5" "223.2" "210.3" "229.8" "219.9" "222.0" "228.1" "224.0" "161.9" "" "" "" "" "" "" "" "" "" "" "105.2" "113.9" "127.8" "96.9" "124.3" "122.3" "130.6" "124.5" "125.6" "161.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3579121838691215902" "False" "High" "IsMasterProtein" "Q7Z6I6" "Rho GTPase-activating protein 30 OS=Homo sapiens OX=9606 GN=ARHGAP30 PE=1 SV=3" "0.000" "False" "30.391" "6" "7" "7" "7" "1101" "118.5" "4.81" "19.85" "7" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00620" "257106" "ENSG00000186517" "ARHGAP30" "hsa:257106; Q5SY52; Q5SY53; Q5SY54; Q6ZML6; Q7Z3J8; Q7Z6I6; Q86XI7" "" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOU GTPase cycle" "4" "0" "1.006" "0.958" "1.225" "1.097" "1.109" "1.526" "1.602" "1.538" "1.122" "196.7" "198.0" "188.5" "240.9" "215.8" "218.1" "300.2" "315.1" "302.5" "220.6" "" "" "" "" "" "" "" "" "" "" "104.2" "109.8" "107.9" "111.0" "116.8" "121.3" "176.7" "172.0" "169.7" "220.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6941898924238947203" "False" "High" "IsMasterProtein" "P52565" "Rho GDP-dissociation inhibitor 1 OS=Homo sapiens OX=9606 GN=ARHGDIA PE=1 SV=3" "0.000" "False" "30.374" "22" "5" "22" "5" "204" "23.2" "5.11" "52.71" "5" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf02115" "396" "ENSG00000141522" "ARHGDIA" "A8MXW0; B2R5X1; B4DDD3; B4DUV9; hsa:396; P52565; Q6IBM5" "Ciliary landscape; Nephrotic syndrome; Vasopressin-regulated water reabsorption" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOH GTPase cycle; Axonal growth stimulation; Axonal growth inhibition (RHOA activation)" "12" "0" "0.999" "1.091" "0.931" "0.895" "0.951" "0.892" "1.009" "1.003" "0.769" "1525.1" "1523.3" "1664.5" "1420.5" "1365.5" "1450.4" "1360.4" "1539.4" "1529.8" "1173.4" "" "" "" "" "" "" "" "" "" "" "807.5" "844.5" "953.2" "654.2" "738.8" "806.8" "800.6" "840.3" "858.2" "1173.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4113768837461094803" "False" "High" "IsMasterProtein" "A0AVT1" "Ubiquitin-like modifier-activating enzyme 6 OS=Homo sapiens OX=9606 GN=UBA6 PE=1 SV=1" "0.000" "False" "30.341" "9" "9" "10" "9" "1052" "117.9" "6.14" "29.27" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00899, Pf09358, Pf10585, Pf16190, Pf16191" "55236" "ENSG00000033178" "UBA6" "A0AVT1; A6N8M7; B2RAV3; hsa:55236; Q4W5K0; Q6UV21; Q86T78; Q86TC7; Q8N5T3; Q8N9E4; Q9H3T7; Q9NVC9" "" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "1.054" "1.032" "1.096" "1.105" "1.093" "0.997" "0.763" "1.013" "4.046" "649.4" "684.6" "670.1" "711.5" "717.5" "709.7" "647.6" "495.6" "657.9" "2627.2" "" "" "" "" "" "" "" "" "" "" "343.8" "379.5" "383.7" "327.7" "388.2" "394.8" "381.2" "270.6" "369.1" "2627.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5656717572997732758" "False" "High" "IsMasterProtein" "P30566" "Adenylosuccinate lyase OS=Homo sapiens OX=9606 GN=ADSL PE=1 SV=2" "0.000" "False" "30.338" "16" "8" "11" "8" "484" "54.9" "7.11" "32.32" "8" "other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00206, Pf10397" "158" "ENSG00000239900" "ADSL" "B0QY76; hsa:158; O75495; P30566; Q5TI34" "" "Purine ribonucleoside monophosphate biosynthesis" "1" "0" "0.955" "0.914" "0.930" "0.978" "0.946" "0.914" "0.929" "0.892" "0.525" "780.7" "745.8" "713.8" "726.2" "763.3" "738.7" "713.6" "725.1" "696.3" "409.8" "" "" "" "" "" "" "" "" "" "" "413.4" "413.5" "408.8" "334.4" "413.0" "410.9" "420.0" "395.8" "390.6" "409.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-658594625945977388" "False" "High" "IsMasterProtein" "O00139" "Kinesin-like protein KIF2A OS=Homo sapiens OX=9606 GN=KIF2A PE=1 SV=3" "0.000" "False" "30.335" "12" "9" "11" "8" "706" "79.9" "6.68" "23.06" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "3796" "ENSG00000068796" "KIF2A" "A5YM42; A5YM54; B4DY54; D3DW97; E9PB70; hsa:3796; O00139; Q7Z5I3; Q8N5Q7" "" "COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Kinesins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "9" "1" "1.004" "0.985" "1.081" "1.057" "1.090" "0.983" "0.897" "0.974" "1.509" "881.2" "884.5" "867.7" "952.1" "931.3" "960.5" "865.8" "790.6" "858.2" "1330.1" "" "" "" "" "" "" "" "" "" "" "466.6" "490.4" "496.9" "438.5" "503.9" "534.3" "509.6" "431.6" "481.4" "1330.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-629472087456424791" "False" "High" "IsMasterProtein" "Q09472" "Histone acetyltransferase p300 OS=Homo sapiens OX=9606 GN=EP300 PE=1 SV=2" "0.000" "False" "30.291" "4" "9" "11" "6" "2414" "264.0" "8.50" "21.88" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00439, Pf00569, Pf02135, Pf02172, Pf06001, Pf08214, Pf09030" "2033" "ENSG00000100393" "EP300" "B1AKC2; hsa:2033; Q09472" "Androgen receptor signaling pathway; Energy metabolism; Cell cycle; Glioblastoma signaling pathways; Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Kit receptor signaling pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; IL-4 signaling pathway; Wnt signaling pathway and pluripotency; Prion disease pathway; Clear cell renal cell carcinoma pathways; Ebola virus infection in host; Type 2 papillary renal cell carcinoma; Hepatitis B infection; Male infertility; TGF-beta receptor signaling in skeletal dysplasias; CAMKK2 pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; CCL18 signaling pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis; Urotensin-II-mediated signaling pathway; Pathophysiological roles of DUX4 in FSHD1; HDAC6 interactions in the central nervous system; TGF-beta receptor signaling; Notch signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "Regulation of RUNX3 expression and activity; Heme signaling; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; Transcriptional regulation of granulopoiesis; STAT3 nuclear events downstream of ALK signaling; Attenuation phase; Metalloprotease DUBs; Zygotic genome activation (ZGA); PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NGF-stimulated transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; SUMOylation of transcription cofactors; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of TP53 Activity through Methylation; NFE2L2 regulating anti-oxidant/detoxification enzymes; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; NOTCH1 Intracellular Domain Regulates Transcription; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NFE2L2 regulating MDR associated enzymes; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Nuclear events mediated by NFE2L2; NFE2L2 regulates pentose phosphate pathway genes; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; NOTCH3 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NFE2L2 regulating inflammation associated genes; NFE2L2 regulating tumorigenic genes; NFE2L2 regulating ER-stress associated genes; Regulation of NFE2L2 gene expression; RORA activates gene expression; CD209 (DC-SIGN) signaling; Polo-like kinase mediated events; Activation of the TFAP2 (AP-2) family of transcription factors; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses; RUNX3 regulates p14-ARF; Regulation of gene expression by Hypoxia-inducible Factor; PI5P Regulates TP53 Acetylation; NOTCH2 intracellular domain regulates transcription; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "91" "2" "0.998" "0.942" "1.018" "1.089" "1.024" "0.968" "1.012" "1.019" "0.973" "596.0" "594.7" "561.4" "606.7" "649.3" "610.0" "576.7" "603.1" "607.3" "579.9" "" "" "" "" "" "" "" "" "" "" "315.6" "329.7" "321.5" "279.4" "351.3" "339.3" "339.4" "329.2" "340.7" "579.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5377093586219491132" "False" "High" "IsMasterProtein" "Q5VW36" "Focadhesin OS=Homo sapiens OX=9606 GN=FOCAD PE=1 SV=2" "0.000" "False" "30.251" "4" "7" "7" "7" "1801" "199.9" "6.62" "20.23" "7" "other biological processes" "cytosol;other cell component" "" "Pf11229, Pf12530" "54914" "ENSG00000188352" "FOCAD" "D3DRJ9; hsa:54914; Q5VW36; Q6ZME1; Q8IZG0; Q96JM8; Q96MS9; Q9BVF3; Q9NX87" "" "" "0" "0" "1.049" "0.997" "0.976" "0.957" "1.045" "1.027" "0.951" "1.055" "0.698" "499.7" "524.1" "498.1" "487.6" "478.3" "522.3" "513.2" "475.4" "527.3" "348.8" "" "" "" "" "" "" "" "" "" "" "264.6" "290.6" "285.3" "224.5" "258.8" "290.5" "302.0" "259.5" "295.8" "348.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6901270763620924094" "False" "High" "IsMasterProtein" "Q6P1N9" "Deoxyribonuclease TATDN1 OS=Homo sapiens OX=9606 GN=TATDN1 PE=1 SV=2" "0.000" "False" "30.242" "25" "8" "10" "8" "297" "33.6" "6.96" "24.73" "8" "DNA metabolism" "nucleus" "other molecular function" "Pf01026" "83940" "ENSG00000147687; ENSG00000291730" "TATDN1" "B2R5J0; hsa:83940; Q6P1N9; Q8TD02; Q9BY40" "" "" "0" "0" "0.955" "1.043" "0.938" "1.010" "0.996" "1.058" "1.031" "1.013" "0.800" "1226.6" "1171.7" "1279.1" "1150.8" "1239.1" "1221.4" "1297.8" "1264.5" "1242.6" "981.5" "" "" "" "" "" "" "" "" "" "" "649.5" "649.6" "732.6" "530.0" "670.4" "679.4" "763.8" "690.2" "697.1" "981.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6719730535871434509" "False" "High" "IsMasterProtein" "P16989" "Y-box-binding protein 3 OS=Homo sapiens OX=9606 GN=YBX3 PE=1 SV=4" "0.000" "False" "30.232" "19" "6" "13" "4" "372" "40.1" "9.77" "37.03" "6" "stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00313" "8531" "ENSG00000060138" "YBX3" "B2RBW6; hsa:8531; P16989; Q14121; Q969N6; Q96B76" "RalA downstream regulated genes; Apoptosis-related network due to altered Notch3 in ovarian cancer" "" "2" "0" "1.004" "1.053" "1.064" "0.978" "0.981" "0.944" "0.959" "0.820" "0.570" "830.0" "833.3" "874.3" "883.5" "812.0" "813.8" "783.9" "795.6" "680.8" "473.2" "" "" "" "" "" "" "" "" "" "" "439.5" "462.0" "500.7" "406.9" "439.3" "452.7" "461.4" "434.3" "381.9" "473.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-662139928789152118" "False" "High" "IsMasterProtein" "Q8WYJ6" "Septin-1 OS=Homo sapiens OX=9606 GN=SEPTIN1 PE=1 SV=3" "0.000" "False" "30.199" "24" "8" "12" "8" "372" "42.4" "5.80" "33.15" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00735" "1731" "ENSG00000180096" "SEPTIN1" "B4DVE6; hsa:1731; Q658T1; Q8NEZ1; Q8WYJ6; Q96EL4; Q9H285" "" "" "0" "0" "1.037" "0.994" "1.042" "1.073" "1.070" "0.972" "0.948" "0.993" "0.682" "910.9" "944.4" "905.7" "949.3" "977.8" "974.6" "885.5" "863.8" "904.9" "621.5" "" "" "" "" "" "" "" "" "" "" "482.3" "523.6" "518.7" "437.2" "529.0" "542.1" "521.1" "471.5" "507.6" "621.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8736083768290238180" "False" "High" "IsMasterProtein" "Cont_P13647" "Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3" "0.000" "True" "30.184" "9" "7" "10" "2" "590" "62.3" "7.74" "31.85" "7" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;cytoskeletal activity;other molecular function" "Pf00038, Pf16208" "3852" "ENSG00000186081" "KRT5" "hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91" "" "Formation of the cornified envelope; Type I hemidesmosome assembly" "3" "1" "2.486" "0.567" "0.627" "0.502" "0.662" "0.923" "0.616" "0.369" "0.586" "381.0" "947.3" "215.9" "238.8" "191.4" "252.3" "351.8" "234.8" "140.5" "223.2" "" "" "" "" "" "" "" "" "" "" "201.7" "525.2" "123.7" "110.0" "103.6" "140.3" "207.0" "128.2" "78.8" "223.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6990547013884615551" "False" "High" "IsMasterProtein" "Q5JSH3" "WD repeat-containing protein 44 OS=Homo sapiens OX=9606 GN=WDR44 PE=1 SV=1" "0.000" "False" "30.110" "11" "8" "9" "8" "913" "101.3" "5.45" "22.53" "8" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "54521" "ENSG00000131725" "WDR44" "B4DSE9; F8W913; hsa:54521; Q0JS52; Q0JTF3; Q5JSH2; Q5JSH3; Q6ZSC1; Q7Z365; Q7Z3P6; Q8NAU8; Q8NHU5; Q9NUV4" "Ectoderm differentiation" "" "1" "0" "0.974" "1.066" "0.946" "1.031" "1.042" "0.954" "1.084" "1.011" "0.478" "559.9" "545.4" "596.7" "529.4" "577.1" "583.2" "534.4" "606.9" "565.8" "267.8" "" "" "" "" "" "" "" "" "" "" "296.5" "302.4" "341.7" "243.8" "312.3" "324.4" "314.5" "331.3" "317.4" "267.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8796563562417500540" "False" "High" "IsMasterProtein" "P51532" "Transcription activator BRG1 OS=Homo sapiens OX=9606 GN=SMARCA4 PE=1 SV=2" "0.000" "False" "30.094" "5" "9" "11" "5" "1647" "184.5" "7.88" "24.89" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00439, Pf07529, Pf07533, Pf08880, Pf14619" "6597" "ENSG00000127616" "SMARCA4" "B1A8Z4; B1A8Z5; B1A8Z6; B1A8Z7; E9PBR8; hsa:6597; O95052; P51532; Q9HBD3" "Androgen receptor network in prostate cancer; Pre-implantation embryo; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Tumor suppressor activity of SMARCB1; Rett syndrome; Thermogenesis; Kleefstra syndrome" "Formation of the beta-catenin:TCF transactivating complex; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Interleukin-7 signaling; RMTs methylate histone arginines; EGR2 and SOX10-mediated initiation of Schwann cell myelination" "13" "3" "1.041" "1.064" "1.214" "1.161" "1.061" "1.543" "1.244" "1.538" "4.997" "469.3" "488.7" "499.5" "570.0" "545.0" "498.0" "724.2" "583.8" "721.6" "2345.5" "" "" "" "" "" "" "" "" "" "" "248.5" "271.0" "286.1" "262.5" "294.9" "277.0" "426.2" "318.7" "404.8" "2345.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5015398897820644174" "False" "High" "IsMasterProtein" "O14757" "Serine/threonine-protein kinase Chk1 OS=Homo sapiens OX=9606 GN=CHEK1 PE=1 SV=2" "0.000" "False" "30.090" "18" "7" "7" "7" "476" "54.4" "8.25" "23.20" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1111" "ENSG00000149554" "CHEK1" "A8K934; B4DDD0; B4DSK3; B5BTY6; F5H7S4; H2BI51; hsa:1111; O14757" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATR signaling; ATM signaling in development and disease ; DNA repair pathways, full network; TROP2 regulatory signaling; DNA damage response" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Transcriptional Regulation by E2F6; Signaling by SCF-KIT; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex" "18" "0" "1.028" "1.011" "0.842" "0.852" "0.844" "0.799" "0.760" "0.814" "0.886" "916.3" "942.4" "926.8" "772.0" "780.5" "773.2" "732.4" "696.6" "745.9" "812.2" "" "" "" "" "" "" "" "" "" "" "485.2" "522.5" "530.8" "355.5" "422.3" "430.1" "431.1" "380.3" "418.4" "812.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9033578792166200150" "False" "High" "IsMasterProtein" "Q99729" "Heterogeneous nuclear ribonucleoprotein A/B OS=Homo sapiens OX=9606 GN=HNRNPAB PE=1 SV=2" "0.000" "False" "30.056" "18" "8" "21" "6" "332" "36.2" "8.21" "55.77" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf08143" "3182" "ENSG00000197451" "HNRNPAB" "B3KNN5; D3DWP7; hsa:3182; Q04150; Q8N7U3; Q99729; Q9BQ99" "Pre-implantation embryo; mRNA processing" "" "2" "0" "0.940" "1.083" "0.992" "0.834" "0.861" "0.811" "0.963" "0.850" "0.584" "1898.9" "1785.3" "2055.6" "1883.5" "1584.5" "1634.0" "1539.3" "1828.3" "1614.9" "1108.4" "" "" "" "" "" "" "" "" "" "" "1005.5" "989.8" "1177.2" "867.4" "857.3" "908.9" "905.9" "998.0" "905.9" "1108.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4415570283207223737" "False" "High" "IsMasterProtein" "Q08257" "Quinone oxidoreductase OS=Homo sapiens OX=9606 GN=CRYZ PE=1 SV=1" "0.000" "False" "30.053" "25" "8" "17" "8" "329" "35.2" "8.44" "50.26" "8" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf08240, Pf13602" "1429" "ENSG00000116791" "CRYZ" "A6NN60; D3DQ76; hsa:1429; Q08257; Q53FT0; Q59EU7; Q5HYE7; Q6NSK9" "" "" "0" "0" "0.959" "0.969" "0.932" "0.951" "0.966" "0.972" "1.003" "0.908" "0.512" "1917.8" "1839.5" "1857.6" "1787.8" "1824.2" "1852.4" "1863.2" "1922.8" "1741.8" "981.3" "" "" "" "" "" "" "" "" "" "" "1015.5" "1019.9" "1063.9" "823.4" "986.9" "1030.4" "1096.5" "1049.5" "977.1" "981.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4462152622631022902" "False" "High" "IsMasterProtein" "Q92922" "SWI/SNF complex subunit SMARCC1 OS=Homo sapiens OX=9606 GN=SMARCC1 PE=1 SV=3" "0.000" "False" "29.998" "7" "8" "14" "5" "1105" "122.8" "5.76" "39.35" "8" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf04433, Pf16495, Pf16496, Pf16498" "6599" "ENSG00000173473" "SMARCC1" "hsa:6599; Q17RS0; Q6P172; Q8IWH2; Q92922" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "6" "0" "1.026" "1.007" "1.080" "1.084" "1.036" "1.176" "0.793" "1.269" "6.675" "362.1" "371.6" "364.5" "390.9" "392.3" "374.9" "426.0" "287.3" "459.4" "2417.1" "" "" "" "" "" "" "" "" "" "" "191.7" "206.0" "208.8" "180.0" "212.3" "208.6" "250.7" "156.8" "257.7" "2417.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3313635736816900772" "False" "High" "IsMasterProtein" "O96019" "Actin-like protein 6A OS=Homo sapiens OX=9606 GN=ACTL6A PE=1 SV=1" "0.000" "False" "29.867" "17" "6" "10" "6" "429" "47.4" "5.60" "29.05" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00022" "86" "ENSG00000136518" "ACTL6A" "B3KMN1; D3DNR9; hsa:86; O96019; Q8TAE5; Q9BVS8; Q9H0W6" "Androgen receptor network in prostate cancer; Gastric cancer network 1; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RMTs methylate histone arginines; UCH proteinases; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; HATs acetylate histones; DNA Damage Recognition in GG-NER" "10" "0" "0.993" "1.037" "0.967" "1.055" "1.035" "0.994" "0.997" "0.978" "1.297" "1092.3" "1084.6" "1133.1" "1056.8" "1152.6" "1130.1" "1086.1" "1089.0" "1067.8" "1416.7" "" "" "" "" "" "" "" "" "" "" "578.4" "601.3" "648.9" "486.7" "623.6" "628.6" "639.2" "594.5" "599.0" "1416.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6653202710982051878" "False" "High" "IsMasterProtein" "Q96RL1" "BRCA1-A complex subunit RAP80 OS=Homo sapiens OX=9606 GN=UIMC1 PE=1 SV=2" "0.000" "False" "29.832" "11" "8" "9" "8" "719" "79.7" "5.45" "27.12" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf18282" "51720" "ENSG00000087206" "UIMC1" "A8MSA1; B3KMZ1; B4E3N2; hsa:51720; Q5XKQ1; Q7Z3W7; Q8N5B9; Q96RL1; Q9BZR1; Q9BZR5; Q9UHX7" "5q35 copy number variation" "Nonhomologous End-Joining (NHEJ); Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Metalloprotease DUBs" "6" "0" "0.950" "0.947" "1.077" "0.999" "0.967" "1.082" "1.088" "1.105" "0.767" "632.3" "600.9" "598.8" "680.9" "631.9" "611.3" "684.1" "688.1" "698.5" "484.9" "" "" "" "" "" "" "" "" "" "" "334.8" "333.1" "343.0" "313.6" "341.9" "340.0" "402.6" "375.6" "391.8" "484.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4895248664825856717" "False" "High" "IsMasterProtein" "Q9UGP4" "LIM domain-containing protein 1 OS=Homo sapiens OX=9606 GN=LIMD1 PE=1 SV=1" "0.000" "False" "29.653" "8" "5" "6" "5" "676" "72.1" "6.65" "15.47" "5" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00412" "8994" "ENSG00000144791" "LIMD1" "hsa:8994; Q17RQ1; Q9BQQ9; Q9NQ47; Q9UGP4" "Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Pleural mesothelioma" "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha" "3" "0" "0.969" "1.055" "1.058" "1.112" "0.920" "1.165" "1.150" "1.130" "0.963" "244.4" "236.9" "257.8" "258.5" "271.9" "224.9" "284.8" "281.2" "276.1" "235.3" "" "" "" "" "" "" "" "" "" "" "129.4" "131.4" "147.6" "119.1" "147.1" "125.1" "167.6" "153.5" "154.9" "235.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6123184333862718981" "False" "High" "IsMasterProtein" "Q96BY6" "Dedicator of cytokinesis protein 10 OS=Homo sapiens OX=9606 GN=DOCK10 PE=1 SV=3" "0.000" "False" "29.653" "4" "9" "10" "9" "2186" "249.4" "7.14" "23.51" "9" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "55619" "ENSG00000135905" "DOCK10" "B3FL70; hsa:55619; O75178; Q68DA4; Q96BY6; Q9NW06; Q9NXI8" "" "Factors involved in megakaryocyte development and platelet production; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle" "5" "0" "1.033" "0.981" "0.974" "0.980" "0.942" "0.908" "0.999" "0.964" "0.856" "1038.8" "1072.8" "1018.9" "1011.5" "1018.3" "979.0" "943.0" "1037.3" "1001.7" "889.4" "" "" "" "" "" "" "" "" "" "" "550.0" "594.8" "583.5" "465.8" "550.9" "544.6" "555.0" "566.2" "561.9" "889.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8719545438223687688" "False" "High" "IsMasterProtein" "Q9NWV8" "BRISC and BRCA1-A complex member 1 OS=Homo sapiens OX=9606 GN=BABAM1 PE=1 SV=1" "0.000" "False" "29.632" "19" "4" "6" "4" "329" "36.5" "4.64" "21.43" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "" "29086" "ENSG00000105393" "BABAM1" "A8MQT0; B4DRY9; B4DVR1; hsa:29086; Q6FIA0; Q9NWV8; Q9P018" "5q35 copy number variation" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; Nonhomologous End-Joining (NHEJ)" "6" "0" "0.984" "0.964" "0.981" "1.006" "1.005" "0.983" "1.003" "0.999" "0.632" "744.1" "732.0" "717.4" "729.6" "748.6" "747.7" "731.6" "746.6" "743.3" "470.5" "" "" "" "" "" "" "" "" "" "" "394.0" "405.9" "410.9" "336.0" "405.0" "415.9" "430.6" "407.5" "417.0" "470.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6836075231128367811" "False" "High" "IsMasterProtein" "Q15008" "26S proteasome non-ATPase regulatory subunit 6 OS=Homo sapiens OX=9606 GN=PSMD6 PE=1 SV=1" "0.000" "False" "29.516" "20" "8" "14" "8" "389" "45.5" "5.62" "38.34" "8" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf01399, Pf10602, Pf21154" "9861" "ENSG00000163636" "PSMD6" "A8K2E0; E9PHI9; hsa:9861; Q15008; Q6UV22" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of expression of SLITs and ROBOs; ABC-family proteins mediated transport; Neutrophil degranulation; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Interleukin-1 signaling; Separation of Sister Chromatids; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "1.012" "0.998" "1.000" "1.056" "1.029" "0.971" "0.970" "0.903" "0.681" "1536.3" "1555.3" "1533.2" "1536.1" "1623.1" "1581.2" "1491.8" "1489.7" "1387.9" "1046.9" "" "" "" "" "" "" "" "" "" "" "813.5" "862.3" "878.1" "707.4" "878.1" "879.5" "878.0" "813.2" "778.6" "1046.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1535897714363242613" "False" "High" "IsMasterProtein" "Q15019" "Septin-2 OS=Homo sapiens OX=9606 GN=SEPTIN2 PE=1 SV=1" "0.000" "False" "29.510" "26" "9" "18" "9" "361" "41.5" "6.60" "46.90" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00735" "4735" "ENSG00000168385" "SEPTIN2" "B4DGE8; hsa:4735; Q14132; Q15019; Q53QU3; Q8IUK9; Q96CB0" "2q37 copy number variation syndrome" "Anchoring of the basal body to the plasma membrane" "2" "0" "1.047" "0.991" "0.948" "0.983" "1.018" "1.083" "0.978" "1.011" "0.552" "1146.5" "1200.3" "1136.0" "1086.4" "1127.0" "1166.8" "1241.9" "1121.0" "1159.4" "632.5" "" "" "" "" "" "" "" "" "" "" "607.1" "665.5" "650.6" "500.3" "609.8" "649.0" "730.9" "611.9" "650.4" "632.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6980726595472841033" "False" "High" "IsMasterProtein" "P24941" "Cyclin-dependent kinase 2 OS=Homo sapiens OX=9606 GN=CDK2 PE=1 SV=2" "0.000" "False" "29.499" "17" "5" "14" "4" "298" "33.9" "8.68" "37.20" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069" "1017" "ENSG00000123374" "CDK2" "A8K7C6; hsa:1017; O75100; P24941" "miRNA regulation of DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Oncostatin M signaling pathway; Spinal cord injury; Retinoblastoma gene in cancer; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; PI3K-Akt signaling pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; DNA replication; p53 transcriptional gene network; Pleural mesothelioma; Sphingolipid metabolism in senescence; Urotensin-II-mediated signaling pathway; ID signaling pathway; TROP2 regulatory signaling; DNA damage response" "CDK-mediated phosphorylation and removal of Cdc6; Regulation of APC/C activators between G1/S and early anaphase; Senescence-Associated Secretory Phenotype (SASP); TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Orc1 removal from chromatin; Regulation of TP53 Degradation; SCF(Skp2)-mediated degradation of p27/p21; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; G2 Phase; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Telomere Extension By Telomerase; Factors involved in megakaryocyte development and platelet production; Processing of DNA double-strand break ends; Cyclin A/B1/B2 associated events during G2/M transition; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Transcriptional regulation of granulopoiesis; G0 and Early G1; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; p53-Dependent G1 DNA Damage Response; PTK6 Regulates Cell Cycle" "47" "0" "1.032" "1.099" "1.199" "1.139" "1.097" "1.094" "1.081" "1.059" "0.917" "682.5" "704.2" "749.8" "818.5" "777.6" "749.0" "746.3" "738.0" "723.0" "625.7" "" "" "" "" "" "" "" "" "" "" "361.4" "390.4" "429.4" "376.9" "420.7" "416.6" "439.2" "402.8" "405.6" "625.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4996428185622591073" "False" "High" "IsMasterProtein" "Q9NZB2" "Constitutive coactivator of PPAR-gamma-like protein 1 OS=Homo sapiens OX=9606 GN=FAM120A PE=1 SV=2" "0.000" "False" "29.477" "8" "8" "9" "8" "1118" "121.8" "8.88" "25.29" "8" "" "plasma membrane;other membranes;cytosol;nucleus" "" "" "23196" "ENSG00000048828" "FAM120A" "A6NGU0; C4AMC6; hsa:23196; O60649; Q14688; Q4VXF4; Q4VXF5; Q4VXG2; Q86V69; Q96I21; Q9NZB1; Q9NZB2" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.000" "1.013" "1.134" "1.093" "1.105" "0.991" "1.005" "1.104" "1.712" "299.5" "299.6" "303.3" "339.6" "327.3" "331.0" "296.9" "301.0" "330.8" "512.9" "" "" "" "" "" "" "" "" "" "" "158.6" "166.1" "173.7" "156.4" "177.1" "184.1" "174.7" "164.3" "185.6" "512.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6919500497101416540" "False" "High" "IsMasterProtein" "Q9UJU6" "Drebrin-like protein OS=Homo sapiens OX=9606 GN=DBNL PE=1 SV=1" "0.000" "False" "29.462" "18" "7" "9" "7" "430" "48.2" "5.05" "26.71" "7" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00241, Pf14604" "28988" "ENSG00000136279" "DBNL" "A4D2I9; B4DDP6; B4DEM2; C9J7P1; hsa:28988; P84070; Q6IAI8; Q96F30; Q96K74; Q9HBN8; Q9NR72; Q9UJU6" "T-cell receptor signaling pathway" "Neutrophil degranulation; Neurexins and neuroligins; Caspase-mediated cleavage of cytoskeletal proteins" "4" "0" "0.941" "0.975" "1.043" "0.929" "0.939" "1.074" "0.893" "0.968" "2.199" "893.0" "840.0" "870.3" "931.7" "829.5" "839.0" "959.5" "797.2" "864.6" "1963.5" "" "" "" "" "" "" "" "" "" "" "472.9" "465.7" "498.4" "429.1" "448.8" "466.7" "564.7" "435.2" "485.0" "1963.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-91982353768306611" "False" "High" "IsMasterProtein" "P00492" "Hypoxanthine-guanine phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=HPRT1 PE=1 SV=2" "0.000" "False" "29.391" "37" "7" "18" "7" "218" "24.6" "6.68" "33.19" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00156" "3251" "ENSG00000165704" "HPRT1" "A6NHF0; B2R8M9; hsa:3251; P00492" "Mesodermal commitment pathway" "Azathioprine ADME; Purine salvage; Defective HPRT1 disrupts guanine and hypoxanthine salvage" "4" "0" "0.989" "0.946" "1.061" "1.040" "1.019" "1.025" "1.036" "0.907" "0.579" "876.7" "866.9" "829.8" "930.2" "911.8" "893.4" "899.0" "908.6" "794.8" "507.8" "" "" "" "" "" "" "" "" "" "" "464.2" "480.6" "475.2" "428.4" "493.3" "496.9" "529.1" "495.9" "445.9" "507.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8106966376198238351" "False" "High" "IsMasterProtein" "Q01844" "RNA-binding protein EWS OS=Homo sapiens OX=9606 GN=EWSR1 PE=1 SV=1" "0.000" "False" "29.389" "9" "4" "9" "4" "656" "68.4" "9.33" "33.10" "4" "" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00076, Pf00641" "2130" "ENSG00000182944" "EWSR1" "B0QYK1; hsa:2130; Q01844; Q5THL0; Q92635; Q96FE8; Q96MN4; Q96MX4; Q9BWA2" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.909" "1.137" "0.884" "1.035" "0.876" "0.907" "1.019" "0.970" "0.502" "342.8" "311.5" "389.6" "303.0" "354.7" "300.2" "310.9" "349.4" "332.5" "172.2" "" "" "" "" "" "" "" "" "" "" "181.5" "172.7" "223.1" "139.5" "191.9" "167.0" "183.0" "190.7" "186.5" "172.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8481404637455697567" "False" "High" "IsMasterProtein" "Q9C0B1" "Alpha-ketoglutarate-dependent dioxygenase FTO OS=Homo sapiens OX=9606 GN=FTO PE=1 SV=3" "0.000" "False" "29.381" "21" "9" "9" "9" "505" "58.2" "5.22" "22.48" "9" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12933, Pf12934" "79068" "ENSG00000140718" "FTO" "A2RUH1; B2RNS0; hsa:79068; Q0P676; Q7Z785; Q9C0B1" "FTO obesity variant mechanism" "Reversal of alkylation damage by DNA dioxygenases" "2" "0" "1.031" "0.973" "1.114" "1.009" "0.991" "1.073" "1.012" "0.871" "0.649" "1275.7" "1315.4" "1241.8" "1421.1" "1286.6" "1264.2" "1368.6" "1290.7" "1111.3" "827.9" "" "" "" "" "" "" "" "" "" "" "675.5" "729.3" "711.2" "654.5" "696.1" "703.2" "805.5" "704.6" "623.4" "827.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4481377694352566724" "False" "High" "IsMasterProtein" "P15121" "Aldo-keto reductase family 1 member B1 OS=Homo sapiens OX=9606 GN=AKR1B1 PE=1 SV=3" "0.000" "False" "29.360" "20" "8" "9" "7" "316" "35.8" "6.98" "26.89" "8" "other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus" "other molecular function" "Pf00248" "231" "ENSG00000085662" "AKR1B1" "B2R8N3; hsa:231; P15121; Q5U031; Q6FGA4; Q6ICP2; Q9BS21; Q9UCI9" "Eicosanoid metabolism via cyclooxygenases (COX); Disorders of galactose metabolism ; Omega-6-fatty acids in senescence; Polyol pathway; Metapathway biotransformation Phase I and II" "Pregnenolone biosynthesis; Fructose biosynthesis" "7" "0" "0.958" "1.006" "0.998" "0.994" "1.062" "0.992" "1.037" "0.979" "0.569" "1056.2" "1011.9" "1062.1" "1054.3" "1050.3" "1121.6" "1047.7" "1095.7" "1033.9" "600.6" "" "" "" "" "" "" "" "" "" "" "559.2" "561.0" "608.3" "485.5" "568.2" "623.9" "616.6" "598.1" "580.0" "600.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7577661902964436810" "False" "High" "IsMasterProtein" "Q3LXA3" "Triokinase/FMN cyclase OS=Homo sapiens OX=9606 GN=TKFC PE=1 SV=2" "0.000" "False" "29.353" "13" "7" "11" "7" "575" "58.9" "7.49" "32.41" "7" "other metabolic processes;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf02733, Pf02734" "26007" "ENSG00000149476" "TKFC" "hsa:26007; Q2L9C1; Q3LXA3; Q53EQ9; Q9BVA7; Q9H895" "Novel intracellular components of RIG-I-like receptor pathway" "SARS-CoV-1 activates/modulates innate immune responses; SARS-CoV-2 activates/modulates innate and adaptive immune responses; DDX58/IFIH1-mediated induction of interferon-alpha/beta; Fructose catabolism" "5" "0" "0.992" "1.038" "1.085" "1.030" "1.036" "0.985" "0.945" "0.950" "0.605" "744.3" "738.5" "772.7" "807.8" "766.8" "771.4" "733.5" "703.1" "706.8" "450.5" "" "" "" "" "" "" "" "" "" "" "394.1" "409.4" "442.5" "372.0" "414.8" "429.1" "431.7" "383.8" "396.5" "450.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7105726009165371323" "False" "High" "IsMasterProtein" "P13995" "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD2 PE=1 SV=2" "0.000" "False" "29.307" "18" "7" "16" "7" "350" "37.9" "8.73" "48.30" "7" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00763, Pf02882" "10797" "ENSG00000065911" "MTHFD2" "hsa:10797; P13995; Q53G90; Q53GV5; Q53S36; Q7Z650" "Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways" "Metabolism of folate and pterines" "4" "0" "1.029" "1.002" "1.034" "1.013" "0.983" "0.931" "0.877" "0.856" "0.633" "775.1" "797.3" "777.0" "801.7" "785.0" "761.6" "721.4" "680.1" "663.7" "490.5" "" "" "" "" "" "" "" "" "" "" "410.4" "442.0" "445.0" "369.2" "424.7" "423.7" "424.6" "371.2" "372.3" "490.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8980500697727064305" "False" "High" "IsMasterProtein" "O43815" "Striatin OS=Homo sapiens OX=9606 GN=STRN PE=1 SV=4" "0.000" "False" "29.303" "10" "7" "8" "7" "780" "86.1" "5.27" "25.01" "7" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00400, Pf08232" "6801" "ENSG00000115808" "STRN" "hsa:6801; O43815; Q3KP65; Q53TQ8; Q9NP38" "MET in type 1 papillary renal cell carcinoma" "Extra-nuclear estrogen signaling; PIP3 activates AKT signaling; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins" "8" "0" "0.828" "0.895" "1.058" "1.107" "1.103" "1.116" "1.164" "1.132" "0.679" "233.5" "193.4" "209.1" "247.1" "258.4" "257.5" "260.6" "271.8" "264.3" "158.6" "" "" "" "" "" "" "" "" "" "" "123.6" "107.2" "119.7" "113.8" "139.8" "143.2" "153.4" "148.3" "148.2" "158.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1516801179277526941" "False" "High" "IsMasterProtein" "Q9HB71" "Calcyclin-binding protein OS=Homo sapiens OX=9606 GN=CACYBP PE=1 SV=2" "0.000" "False" "29.273" "32" "7" "14" "7" "228" "26.2" "8.25" "35.82" "7" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf04969, Pf05002, Pf09032" "27101" "ENSG00000116161" "CACYBP" "B2ZWH2; B3KSF1; hsa:27101; O60666; Q5R370; Q5R371; Q9HB71" "Gastric cancer network 2" "" "1" "0" "0.962" "1.010" "0.974" "1.046" "1.072" "0.976" "1.070" "1.092" "0.783" "1626.2" "1563.9" "1642.6" "1584.7" "1701.2" "1743.8" "1587.6" "1740.6" "1776.4" "1274.0" "" "" "" "" "" "" "" "" "" "" "861.1" "867.1" "940.7" "729.8" "920.4" "970.0" "934.3" "950.1" "996.5" "1274.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2836831182499166141" "False" "High" "IsMasterProtein" "O00148" "ATP-dependent RNA helicase DDX39A OS=Homo sapiens OX=9606 GN=DDX39A PE=1 SV=2" "0.000" "False" "29.263" "18" "9" "18" "2" "427" "49.1" "5.68" "46.37" "9" "RNA metabolism OR transcription;other metabolic processes;transport" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271" "10212" "ENSG00000123136" "DDX39A" "B1Q2N1; hsa:10212; O00148; Q8N5M0; Q9BVP6; Q9H5W0" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "1.116" "1.096" "1.185" "1.156" "0.868" "1.152" "0.938" "1.249" "3.115" "77.9" "86.9" "85.3" "92.3" "90.0" "67.6" "89.7" "73.0" "97.3" "242.6" "" "" "" "" "" "" "" "" "" "" "41.2" "48.2" "48.9" "42.5" "48.7" "37.6" "52.8" "39.9" "54.6" "242.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5384337703464320291" "False" "High" "IsMasterProtein" "Q16822" "Phosphoenolpyruvate carboxykinase [GTP], mitochondrial OS=Homo sapiens OX=9606 GN=PCK2 PE=1 SV=4" "0.000" "False" "29.256" "12" "8" "17" "8" "640" "70.7" "7.62" "46.78" "8" "other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf00821, Pf17297" "5106" "ENSG00000100889; ENSG00000285241" "PCK2" "B4DW73; hsa:5106; O43253; Q16822; Q86U01; Q9BV62" "Adipogenesis; Transcription factor regulation in adipogenesis; PPAR signaling pathway; PI3K-Akt signaling pathway; Krebs cycle disorders; DNA damage response (only ATM dependent)" "Gluconeogenesis" "7" "0" "1.020" "1.051" "1.031" "0.958" "0.972" "0.848" "0.949" "0.895" "0.806" "689.5" "703.2" "724.7" "710.9" "660.4" "670.1" "585.1" "654.2" "617.0" "555.9" "" "" "" "" "" "" "" "" "" "" "365.1" "389.9" "415.1" "327.4" "357.3" "372.7" "344.3" "357.1" "346.1" "555.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7869799461247912985" "False" "High" "IsMasterProtein" "Q96GW9" "Methionine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=MARS2 PE=1 SV=2" "0.000" "False" "29.239" "11" "6" "11" "6" "593" "66.5" "8.09" "30.97" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf09334, Pf19303" "92935" "ENSG00000247626" "MARS2" "A0AVC3; hsa:92935; Q76E79; Q8IW62; Q8N7N4; Q96GW9" "Amino acid metabolism" "Mitochondrial tRNA aminoacylation" "2" "0" "1.100" "1.029" "1.165" "1.091" "1.058" "1.041" "1.049" "1.085" "0.574" "799.1" "879.0" "822.1" "930.9" "872.2" "845.2" "832.2" "838.4" "867.3" "458.3" "" "" "" "" "" "" "" "" "" "" "423.1" "487.3" "470.8" "428.7" "471.9" "470.1" "489.8" "457.6" "486.5" "458.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "960640284500961057" "False" "High" "IsMasterProtein" "Q13426" "DNA repair protein XRCC4 OS=Homo sapiens OX=9606 GN=XRCC4 PE=1 SV=2" "0.000" "False" "29.215" "21" "7" "10" "7" "336" "38.3" "4.98" "28.05" "7" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06632" "7518" "ENSG00000152422" "XRCC4" "A8K3X4; hsa:7518; Q13426; Q9BS72; Q9UP94" "Non-homologous end joining; Male infertility; DNA repair pathways, full network; Primary ovarian insufficiency" "SUMOylation of DNA damage response and repair proteins; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation" "7" "0" "0.961" "0.917" "0.984" "0.959" "0.995" "0.984" "0.996" "0.896" "0.592" "1114.0" "1071.0" "1022.0" "1095.9" "1068.5" "1108.7" "1096.6" "1109.7" "997.8" "659.3" "" "" "" "" "" "" "" "" "" "" "589.9" "593.8" "585.3" "504.7" "578.1" "616.7" "645.4" "605.7" "559.8" "659.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2254798804738061271" "False" "High" "IsMasterProtein" "O60271" "C-Jun-amino-terminal kinase-interacting protein 4 OS=Homo sapiens OX=9606 GN=SPAG9 PE=1 SV=4" "0.000" "False" "29.192" "6" "9" "10" "9" "1321" "146.1" "5.15" "22.20" "9" "transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf09744, Pf16471, Pf19056" "9043" "ENSG00000008294" "SPAG9" "A6H8U5; A8MSX0; B4DHH2; hsa:9043; O60271; O60905; Q3KQU8; Q3MKM7; Q86WC7; Q86WC8; Q8IZX7; Q96II0; Q9H811" "" "Myogenesis" "1" "0" "1.019" "0.993" "1.106" "1.063" "1.051" "1.018" "0.900" "1.045" "2.429" "559.9" "570.7" "556.2" "619.4" "594.9" "588.2" "570.0" "503.9" "585.3" "1359.7" "" "" "" "" "" "" "" "" "" "" "296.4" "316.4" "318.5" "285.3" "321.9" "327.2" "335.5" "275.1" "328.4" "1359.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6641856841102683489" "False" "High" "IsMasterProtein" "P62826" "GTP-binding nuclear protein Ran OS=Homo sapiens OX=9606 GN=RAN PE=1 SV=3" "0.000" "False" "29.164" "22" "5" "12" "5" "216" "24.4" "7.49" "33.18" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5901" "ENSG00000132341" "RAN" "A8K3Z8; hsa:5901; P17080; P28746; P28747; P62826; Q6IPB2; Q86V08; Q8NI90; Q9CSP3; Q9CWI7; Q9CZA2; Q9UDJ5; Q9UEU9" "Androgen receptor signaling pathway; miRNA biogenesis; 22q11.2 copy number variation syndrome" "Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Nuclear import of Rev protein; Transcriptional regulation by small RNAs; tRNA processing in the nucleus; Regulation of cholesterol biosynthesis by SREBP (SREBF); MicroRNA (miRNA) biogenesis; Postmitotic nuclear pore complex (NPC) reformation" "11" "0" "0.912" "0.940" "0.779" "0.873" "0.885" "0.967" "0.898" "0.905" "0.498" "1320.5" "1204.3" "1241.5" "1029.2" "1152.6" "1169.2" "1276.3" "1185.7" "1194.8" "657.0" "" "" "" "" "" "" "" "" "" "" "699.2" "667.7" "711.0" "474.0" "623.6" "650.4" "751.2" "647.2" "670.2" "657.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4087674429968217888" "False" "High" "IsMasterProtein" "P63010" "AP-2 complex subunit beta OS=Homo sapiens OX=9606 GN=AP2B1 PE=1 SV=1" "0.000" "False" "29.103" "8" "7" "12" "3" "937" "104.5" "5.38" "31.16" "7" "transport;developmental processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf02883, Pf09066" "163" "ENSG00000006125" "AP2B1" "A6NJP3; hsa:163; P21851; P63010; Q7Z451; Q96J19" "Synaptic vesicle pathway; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; mBDNF and proBDNF regulation of GABA neurotransmission; Markers of kidney cell lineage; 17q12 copy number variation syndrome" "Recycling pathway of L1; MHC class II antigen presentation; Potential therapeutics for SARS; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "20" "4" "1.030" "0.999" "1.072" "1.088" "1.078" "1.128" "1.115" "1.115" "1.141" "1005.0" "1035.0" "1003.9" "1076.9" "1093.6" "1083.7" "1133.5" "1120.1" "1120.8" "1146.9" "" "" "" "" "" "" "" "" "" "" "532.1" "573.8" "574.9" "495.9" "591.7" "602.8" "667.1" "611.4" "628.7" "1146.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5241599952766811941" "False" "High" "IsMasterProtein" "P09211" "Glutathione S-transferase P OS=Homo sapiens OX=9606 GN=GSTP1 PE=1 SV=2" "0.000" "False" "29.078" "32" "5" "12" "5" "210" "23.3" "5.64" "42.12" "5" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02798, Pf14497" "2950" "ENSG00000084207" "GSTP1" "hsa:2950; O00460; P09211; Q15690; Q5TZY3" "Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Exercise-induced circadian regulation; Omega-6-fatty acids in senescence; Arachidonate epoxygenase / epoxide hydrolase; Metapathway biotransformation Phase I and II" "Neutrophil degranulation; Paracetamol ADME; Detoxification of Reactive Oxygen Species; Glutathione conjugation" "11" "0" "0.996" "0.980" "0.912" "0.908" "1.038" "0.828" "0.959" "0.918" "0.666" "724.1" "720.9" "709.3" "660.3" "657.8" "751.5" "599.7" "694.5" "665.0" "482.1" "" "" "" "" "" "" "" "" "" "" "383.4" "399.7" "406.2" "304.1" "355.9" "418.0" "352.9" "379.1" "373.1" "482.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1337195466672693139" "False" "High" "IsMasterProtein" "Q9BZX2" "Uridine-cytidine kinase 2 OS=Homo sapiens OX=9606 GN=UCK2 PE=1 SV=1" "0.000" "False" "29.005" "24" "6" "9" "6" "261" "29.3" "6.70" "23.18" "6" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00485" "7371" "ENSG00000143179" "UCK2" "hsa:7371; Q5VV91; Q7KZV3; Q92528; Q96KG5; Q9BU42; Q9BZX2" "Fluoropyrimidine activity; Pyrimidine metabolism" "Pyrimidine salvage" "3" "0" "1.189" "0.928" "1.026" "0.937" "1.007" "0.902" "0.909" "0.851" "0.639" "459.2" "546.2" "426.2" "471.4" "430.2" "462.3" "414.3" "417.2" "391.0" "293.3" "" "" "" "" "" "" "" "" "" "" "243.2" "302.8" "244.1" "217.1" "232.8" "257.1" "243.8" "227.8" "219.3" "293.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-681400762000750361" "False" "High" "IsMasterProtein" "O60749" "Sorting nexin-2 OS=Homo sapiens OX=9606 GN=SNX2 PE=1 SV=2" "0.000" "False" "29.000" "14" "7" "11" "6" "519" "58.4" "5.12" "30.95" "7" "cell organization and biogenesis;transport" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787, Pf03700, Pf09325" "6643" "ENSG00000205302" "SNX2" "B3KN44; B4DEK4; B7Z408; hsa:6643; O43650; O60749; P82862; Q53XK8; Q597H6; Q9BTS8" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "0.938" "0.864" "0.970" "0.960" "1.038" "0.988" "0.840" "1.001" "0.942" "405.2" "380.1" "350.3" "393.2" "389.0" "420.8" "400.3" "340.3" "405.6" "381.8" "" "" "" "" "" "" "" "" "" "" "214.6" "210.7" "200.6" "181.1" "210.5" "234.0" "235.6" "185.7" "227.5" "381.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2439136335340173205" "False" "High" "IsMasterProtein" "P22681" "E3 ubiquitin-protein ligase CBL OS=Homo sapiens OX=9606 GN=CBL PE=1 SV=2" "0.000" "False" "28.918" "9" "6" "7" "6" "906" "99.6" "6.54" "18.95" "6" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00097, Pf00627, Pf02262, Pf02761, Pf02762" "867" "ENSG00000110395" "CBL" "A3KMP8; P22681" "RANKL/RANK signaling pathway; Prolactin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Physico-chemical features and toxicity-associated pathways; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; IL-4 signaling pathway; MET in type 1 papillary renal cell carcinoma; EGF/EGFR signaling pathway; Insulin signaling; IL-2 signaling pathway; 4p16.3 copy number variation; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor signaling pathway" "Regulation of signaling by CBL; Regulation of KIT signaling; Negative regulation of FLT3; Cargo recognition for clathrin-mediated endocytosis; Interleukin-6 signaling; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Signaling by CSF1 (M-CSF) in myeloid cells; Spry regulation of FGF signaling; TGF-beta receptor signaling activates SMADs; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; FLT3 signaling by CBL mutants" "39" "0" "0.949" "0.981" "1.004" "1.084" "1.061" "1.042" "1.071" "1.014" "0.670" "377.0" "357.6" "369.9" "378.3" "408.7" "400.1" "392.7" "403.7" "382.4" "252.6" "" "" "" "" "" "" "" "" "" "" "199.6" "198.3" "211.8" "174.2" "221.1" "222.6" "231.1" "220.4" "214.5" "252.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5794288011295636240" "False" "High" "IsMasterProtein" "O60502" "Protein O-GlcNAcase OS=Homo sapiens OX=9606 GN=OGA PE=1 SV=2" "0.000" "False" "28.898" "8" "8" "12" "8" "916" "102.8" "4.91" "33.33" "8" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf07555" "10724" "ENSG00000198408" "OGA" "B7WPB9; D3DR79; E9PGF9; hsa:10724; O60502; O75166; Q86WV0; Q8IV98; Q9BVA5; Q9HAR0" "" "" "0" "0" "1.031" "0.983" "0.892" "1.018" "1.038" "0.865" "0.949" "0.983" "0.785" "961.2" "991.3" "945.0" "857.5" "978.7" "998.1" "831.4" "911.9" "945.3" "754.7" "" "" "" "" "" "" "" "" "" "" "509.0" "549.6" "541.2" "394.9" "529.5" "555.2" "489.3" "497.8" "530.3" "754.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4354305271704446850" "False" "High" "IsMasterProtein" "O95248" "Myotubularin-related protein 5 OS=Homo sapiens OX=9606 GN=SBF1 PE=1 SV=4" "0.000" "False" "28.850" "5" "9" "9" "9" "1868" "208.3" "6.90" "20.83" "9" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf02141, Pf02893, Pf03456, Pf06602, Pf12335" "6305" "ENSG00000100241" "SBF1" "A0A024R4Z9; A6PVG9; G5E933; hsa:6305; O60228; O95248; Q5JXD8; Q5PPM2; Q96GR9; Q9UGB8" "" "RAB GEFs exchange GTP for GDP on RABs; Synthesis of PIPs at the ER membrane" "2" "0" "1.009" "0.944" "0.948" "1.023" "0.960" "0.934" "0.828" "0.874" "1.083" "401.2" "404.7" "378.7" "380.2" "410.5" "385.1" "374.8" "332.2" "350.7" "434.7" "" "" "" "" "" "" "" "" "" "" "212.4" "224.4" "216.9" "175.1" "222.1" "214.2" "220.6" "181.3" "196.7" "434.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5310524526174993710" "False" "High" "IsMasterProtein" "P51003" "Poly(A) polymerase alpha OS=Homo sapiens OX=9606 GN=PAPOLA PE=1 SV=4" "0.000" "False" "28.769" "8" "5" "9" "5" "745" "82.8" "7.37" "19.37" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04926, Pf04928, Pf20750" "10914" "ENSG00000090060" "PAPOLA" "hsa:10914; P51003; Q86SX4; Q86TV0; Q8IYF5; Q9BVU2" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "1.010" "1.090" "0.996" "1.017" "1.107" "0.872" "0.891" "0.973" "0.793" "377.7" "381.4" "411.5" "376.2" "383.9" "417.9" "329.2" "336.7" "367.3" "299.6" "" "" "" "" "" "" "" "" "" "" "200.0" "211.5" "235.7" "173.2" "207.7" "232.5" "193.7" "183.8" "206.0" "299.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4520162396586865811" "False" "High" "IsMasterProtein" "P51148" "Ras-related protein Rab-5C OS=Homo sapiens OX=9606 GN=RAB5C PE=1 SV=2" "0.000" "False" "28.754" "24" "5" "8" "3" "216" "23.5" "8.41" "28.11" "5" "transport" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5878" "ENSG00000108774" "RAB5C" "F8W1H5; hsa:5878; P51148; Q6FH55; Q9P0Y5" "Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Vasopressin-regulated water reabsorption" "RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Respiratory syncytial virus (RSV) attachment and entry; Clathrin-mediated endocytosis; TBC/RABGAPs" "10" "2" "1.062" "0.990" "1.140" "1.005" "1.087" "1.173" "1.096" "1.018" "0.662" "837.3" "889.5" "828.6" "954.3" "841.5" "910.2" "982.3" "917.6" "852.1" "554.6" "" "" "" "" "" "" "" "" "" "" "443.3" "493.2" "474.5" "439.5" "455.3" "506.3" "578.1" "500.9" "478.0" "554.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4406338825216404645" "False" "High" "IsMasterProtein" "Q16740" "ATP-dependent Clp protease proteolytic subunit, mitochondrial OS=Homo sapiens OX=9606 GN=CLPP PE=1 SV=1" "0.000" "False" "28.739" "29" "6" "13" "6" "277" "30.2" "8.09" "29.38" "6" "protein metabolism;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00574" "8192" "ENSG00000125656" "CLPP" "B2R4W5; hsa:8192; Q16740" "Primary ovarian insufficiency" "Mitochondrial protein degradation" "2" "0" "0.988" "0.931" "0.958" "1.084" "1.045" "0.970" "0.958" "0.969" "0.595" "733.1" "724.0" "682.3" "702.6" "794.8" "766.1" "711.0" "702.5" "710.6" "436.4" "" "" "" "" "" "" "" "" "" "" "388.2" "401.4" "390.8" "323.6" "430.0" "426.1" "418.4" "383.4" "398.7" "436.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "170444545631699205" "False" "High" "IsMasterProtein" "Q9Y4E1" "WASH complex subunit 2C OS=Homo sapiens OX=9606 GN=WASHC2C PE=1 SV=5" "0.000" "False" "28.720" "7" "9" "10" "9" "1341" "147.1" "4.81" "22.76" "9" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15255" "253725" "ENSG00000172661" "WASHC2C" "A0A096LPC5; B4DZQ6; B9EK53; F5H0J6; F5H871; hsa:253725; Q5SQU4; Q5SQU5; Q7L521; Q9UG79; Q9Y4E1" "" "" "0" "0" "1.000" "0.946" "1.104" "1.107" "1.062" "1.379" "1.522" "1.515" "1.009" "1160.7" "1160.4" "1097.6" "1281.3" "1284.5" "1233.1" "1600.6" "1766.4" "1758.3" "1171.0" "" "" "" "" "" "" "" "" "" "" "614.6" "643.4" "628.6" "590.1" "695.0" "685.9" "942.0" "964.2" "986.4" "1171.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7996952704107557877" "False" "High" "IsMasterProtein" "P28331" "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS1 PE=1 SV=3" "0.000" "False" "28.693" "9" "6" "8" "6" "727" "79.4" "6.23" "25.11" "6" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00384, Pf09326, Pf10588, Pf13510" "4719" "ENSG00000023228; ENSG00000283447" "NDUFS1" "B4DIN9; B4DJA0; B4DPG1; B4DUC1; E7ENF3; hsa:4719; P28331; Q53TR8; Q8N1C4; Q8TCC9" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis; Mitochondrial protein degradation" "6" "0" "0.978" "0.927" "0.880" "0.874" "0.849" "0.830" "0.834" "0.794" "0.463" "907.6" "887.6" "841.4" "798.4" "793.7" "770.2" "753.8" "756.9" "720.9" "419.9" "" "" "" "" "" "" "" "" "" "" "480.6" "492.1" "481.9" "367.7" "429.4" "428.4" "443.6" "413.1" "404.4" "419.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6330757226080927514" "False" "High" "IsMasterProtein" "P67775" "Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform OS=Homo sapiens OX=9606 GN=PPP2CA PE=1 SV=1" "0.000" "False" "28.665" "23" "6" "13" "1" "309" "35.6" "5.54" "37.24" "6" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00149" "5515" "ENSG00000113575" "PPP2CA" "hsa:5515; P05323; P13197; P67775" "Sphingolipid pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Dopamine metabolism; Mesodermal commitment pathway; Mesodermal commitment pathway; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Cancer immunotherapy by CTLA4 blockade; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Cyclin A/B1/B2 associated events during G2/M transition; DARPP-32 events; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); PKR-mediated signaling; Regulation of TP53 Degradation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Spry regulation of FGF signaling; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Initiation of Nuclear Envelope (NE) Reformation; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "53" "0" "0.825" "0.999" "0.828" "0.946" "0.923" "1.016" "0.863" "0.764" "0.506" "156.7" "129.4" "156.6" "129.8" "148.3" "144.7" "159.3" "135.3" "119.8" "79.3" "" "" "" "" "" "" "" "" "" "" "83.0" "71.7" "89.7" "59.8" "80.2" "80.5" "93.7" "73.9" "67.2" "79.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3731678403857668842" "False" "High" "IsMasterProtein" "P10768" "S-formylglutathione hydrolase OS=Homo sapiens OX=9606 GN=ESD PE=1 SV=2" "0.000" "False" "28.630" "26" "6" "9" "6" "282" "31.4" "7.02" "28.65" "6" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00756" "2098" "ENSG00000139684" "ESD" "hsa:2098; P10768; Q5TBU8; Q5TBV0; Q5TBV2; Q9BVJ2" "Phase I biotransformations, non-P450" "Glutathione conjugation" "2" "0" "1.009" "0.981" "0.995" "0.948" "1.036" "0.984" "0.986" "0.936" "0.579" "541.1" "545.8" "530.8" "538.6" "512.7" "560.7" "532.4" "533.6" "506.5" "313.5" "" "" "" "" "" "" "" "" "" "" "286.5" "302.6" "304.0" "248.0" "277.4" "311.9" "313.4" "291.3" "284.1" "313.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2351772574129659372" "False" "High" "IsMasterProtein" "P35269" "General transcription factor IIF subunit 1 OS=Homo sapiens OX=9606 GN=GTF2F1 PE=1 SV=2" "0.000" "False" "28.602" "15" "6" "7" "6" "517" "58.2" "7.49" "26.73" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf05793" "2962" "ENSG00000125651" "GTF2F1" "B2RCS0; hsa:2962; P35269; Q9BWN0" "" "Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Estrogen-dependent gene expression; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM" "32" "0" "1.031" "1.012" "1.052" "1.032" "0.957" "0.997" "1.107" "1.107" "0.736" "525.7" "542.1" "531.9" "553.2" "542.7" "502.8" "524.3" "582.2" "582.0" "386.8" "" "" "" "" "" "" "" "" "" "" "278.3" "300.6" "304.6" "254.8" "293.6" "279.7" "308.6" "317.8" "326.5" "386.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4784462983212685670" "False" "High" "IsMasterProtein" "Q96KP4" "Cytosolic non-specific dipeptidase OS=Homo sapiens OX=9606 GN=CNDP2 PE=1 SV=2" "0.000" "False" "28.584" "13" "6" "11" "6" "475" "52.8" "5.97" "24.49" "6" "protein metabolism" "cytosol;nucleus" "other molecular function" "Pf01546, Pf07687" "55748" "ENSG00000133313" "CNDP2" "B3KUG4; hsa:55748; Q8WY59; Q96KP4; Q9BQ94; Q9NVB4; V9HWE5" "" "Glutathione synthesis and recycling; Paracetamol ADME" "2" "0" "0.984" "0.999" "0.945" "1.040" "1.006" "1.009" "0.987" "0.916" "0.841" "841.1" "827.5" "840.6" "795.2" "874.8" "845.8" "848.7" "830.1" "770.1" "707.8" "" "" "" "" "" "" "" "" "" "" "445.3" "458.8" "481.4" "366.2" "473.3" "470.5" "499.5" "453.1" "432.0" "707.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4326632445175340721" "False" "High" "IsMasterProtein" "P55209" "Nucleosome assembly protein 1-like 1 OS=Homo sapiens OX=9606 GN=NAP1L1 PE=1 SV=1" "0.000" "False" "28.576" "16" "4" "11" "3" "391" "45.3" "4.46" "24.87" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00956" "4673" "ENSG00000187109" "NAP1L1" "B3KNT8; B3KV44; hsa:4673; P55209" "VEGFA-VEGFR2 signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "" "2" "0" "1.068" "1.245" "1.167" "1.072" "1.075" "1.131" "0.979" "1.138" "2.381" "122.8" "131.2" "152.9" "143.3" "131.7" "132.0" "138.9" "120.2" "139.7" "292.4" "" "" "" "" "" "" "" "" "" "" "65.0" "72.8" "87.5" "66.0" "71.2" "73.4" "81.8" "65.6" "78.4" "292.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4832303337719112949" "False" "High" "IsMasterProtein" "Q15154" "Pericentriolar material 1 protein OS=Homo sapiens OX=9606 GN=PCM1 PE=1 SV=6" "0.000" "False" "28.555" "5" "11" "12" "10" "2024" "228.4" "5.02" "26.78" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15717" "5108" "ENSG00000078674" "PCM1" "A6NNN6; B4DYD5; E7ETA6; E7EV56; hsa:5108; Q15154; Q58F13; Q6P1K7; Q8NB85; Q9BWC1; Q9H4A2" "Prader-Willi and Angelman syndrome; Joubert syndrome" "Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "9" "0" "1.065" "1.049" "1.006" "1.082" "1.053" "1.278" "1.332" "1.312" "0.969" "537.0" "571.7" "563.6" "540.4" "581.2" "565.6" "686.2" "715.5" "704.5" "520.3" "" "" "" "" "" "" "" "" "" "" "284.4" "317.0" "322.8" "248.9" "314.5" "314.6" "403.9" "390.6" "395.2" "520.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6100436114582122401" "False" "High" "IsMasterProtein" "Q93034" "Cullin-5 OS=Homo sapiens OX=9606 GN=CUL5 PE=1 SV=4" "0.000" "False" "28.547" "9" "8" "10" "8" "780" "90.9" "7.94" "28.80" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;transport;signal transduction" "cytosol;nucleus;other cell component" "transporter activity;other molecular function" "Pf00888, Pf10557" "8065" "ENSG00000166266" "CUL5" "A8K960; O14766; Q93034; Q9BZC6" "Apoptosis-related network due to altered Notch3 in ovarian cancer; Dual hijack model of Vif in HIV infection; Modulators of TCR signaling and T cell activation; 10q11.21q11.23 copy number variation syndrome" "Antigen processing: Ubiquitination & Proteasome degradation; Vif-mediated degradation of APOBEC3G; Neddylation; Inactivation of CSF3 (G-CSF) signaling; Downregulation of ERBB2 signaling; Evasion by RSV of host interferon responses" "10" "0" "1.082" "1.001" "1.074" "1.030" "1.027" "1.052" "1.024" "1.017" "0.698" "747.4" "808.5" "748.2" "802.9" "769.5" "767.7" "786.1" "765.4" "759.9" "521.6" "" "" "" "" "" "" "" "" "" "" "395.7" "448.2" "428.5" "369.7" "416.3" "427.1" "462.6" "417.8" "426.3" "521.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "598569642609282214" "False" "High" "IsMasterProtein" "Q9BRS2" "Serine/threonine-protein kinase RIO1 OS=Homo sapiens OX=9606 GN=RIOK1 PE=1 SV=2" "0.000" "False" "28.535" "13" "7" "10" "7" "568" "65.5" "6.19" "21.85" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf01163" "83732" "ENSG00000124784" "RIOK1" "B2RB28; Q8NDC8; Q96NV9; Q9BRS2" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "0.946" "0.969" "1.013" "1.112" "1.057" "1.024" "1.058" "1.047" "0.594" "543.4" "514.0" "526.7" "550.7" "604.2" "574.4" "556.2" "574.7" "568.9" "322.8" "" "" "" "" "" "" "" "" "" "" "287.7" "285.0" "301.7" "253.6" "326.9" "319.5" "327.3" "313.7" "319.1" "322.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2491250249564736583" "False" "High" "IsMasterProtein" "P49902" "Cytosolic purine 5'-nucleotidase OS=Homo sapiens OX=9606 GN=NT5C2 PE=1 SV=1" "0.000" "False" "28.516" "16" "8" "12" "8" "561" "64.9" "6.14" "27.18" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf05761" "22978" "ENSG00000076685" "NT5C2" "B7Z382; D3DR91; hsa:22978; P49902; Q5JUV5" "" "Purine catabolism; Ribavirin ADME; Abacavir metabolism" "3" "0" "0.940" "0.964" "0.948" "0.984" "0.996" "0.968" "0.880" "0.849" "1.478" "1222.6" "1149.0" "1178.3" "1158.6" "1203.3" "1217.8" "1183.6" "1075.4" "1037.8" "1807.1" "" "" "" "" "" "" "" "" "" "" "647.4" "637.0" "674.8" "533.6" "651.0" "677.4" "696.6" "587.0" "582.2" "1807.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3877327812570757942" "False" "High" "IsMasterProtein" "P50570" "Dynamin-2 OS=Homo sapiens OX=9606 GN=DNM2 PE=1 SV=2" "0.000" "False" "28.512" "11" "10" "14" "10" "870" "98.0" "7.44" "36.04" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00350, Pf01031, Pf02212" "1785" "ENSG00000079805" "DNM2" "A8K1B6; E7EV30; E9PEQ4; hsa:1785; K7ESI9; P50570; Q5I0Y0; Q7Z5S3; Q9UPH4" "Synaptic vesicle pathway; Fragile X syndrome; Intracellular trafficking proteins involved in CMT neuropathy" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis; Recycling pathway of L1; NGF-stimulated transcription; Toll Like Receptor 4 (TLR4) Cascade; NOSTRIN mediated eNOS trafficking; Retrograde neurotrophin signalling; Formation of annular gap junctions" "14" "0" "1.038" "0.983" "0.988" "1.040" "1.029" "0.875" "0.752" "0.859" "1.588" "1235.8" "1282.5" "1215.2" "1221.6" "1285.8" "1271.1" "1081.3" "929.2" "1061.5" "1962.8" "" "" "" "" "" "" "" "" "" "" "654.4" "711.0" "695.9" "562.6" "695.7" "707.0" "636.4" "507.2" "595.5" "1962.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8985233522455606046" "False" "High" "IsMasterProtein" "P61758" "Prefoldin subunit 3 OS=Homo sapiens OX=9606 GN=VBP1 PE=1 SV=4" "0.000" "False" "28.482" "34" "8" "18" "8" "197" "22.6" "7.11" "41.39" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02996" "7411" "ENSG00000155959" "VBP1" "B2R8L5; B4DWR3; F5H2A7; hsa:7411; O55228; P61758; Q15765; Q5JT81; Q86X96" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "1.024" "1.159" "0.990" "1.017" "0.991" "0.972" "1.113" "1.045" "0.673" "1492.4" "1528.1" "1729.6" "1477.5" "1518.4" "1478.2" "1451.1" "1661.4" "1559.5" "1003.9" "" "" "" "" "" "" "" "" "" "" "790.2" "847.2" "990.6" "680.4" "821.5" "822.2" "854.0" "906.9" "874.8" "1003.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8818107332528144144" "False" "High" "IsMasterProtein" "Q9H4E7" "Differentially expressed in FDCP 6 homolog OS=Homo sapiens OX=9606 GN=DEF6 PE=1 SV=1" "0.000" "False" "28.474" "10" "7" "7" "7" "631" "73.9" "6.05" "17.92" "7" "transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf00169" "50619" "ENSG00000023892" "DEF6" "hsa:50619; Q86VF4; Q9H4E7" "" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle" "4" "0" "1.135" "0.974" "0.965" "1.160" "1.202" "1.099" "0.306" "1.102" "9.457" "226.2" "256.7" "220.3" "218.2" "262.3" "271.9" "248.7" "69.3" "249.3" "2139.4" "" "" "" "" "" "" "" "" "" "" "119.8" "142.3" "126.2" "100.5" "141.9" "151.2" "146.4" "37.8" "139.8" "2139.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2487901490658103836" "False" "High" "IsMasterProtein" "O75995" "SAM and SH3 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=SASH3 PE=1 SV=2" "0.000" "False" "28.437" "18" "5" "12" "5" "380" "41.6" "5.27" "45.65" "5" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "" "Pf00536, Pf07653, Pf12485" "54440" "ENSG00000122122" "SASH3" "A6NCH1; A8K7K8; hsa:54440; O75995; Q5JZ38" "" "" "0" "0" "0.980" "0.950" "0.983" "0.980" "0.987" "1.003" "0.980" "0.975" "0.737" "542.5" "531.8" "515.6" "533.0" "531.5" "535.6" "544.1" "531.5" "529.2" "399.8" "" "" "" "" "" "" "" "" "" "" "287.2" "294.8" "295.3" "245.5" "287.6" "297.9" "320.2" "290.1" "296.8" "399.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2375108519350628678" "False" "High" "IsMasterProtein" "Q13547" "Histone deacetylase 1 OS=Homo sapiens OX=9606 GN=HDAC1 PE=1 SV=1" "0.000" "False" "28.372" "15" "8" "14" "4" "482" "55.1" "5.48" "28.47" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00850" "3065" "ENSG00000116478" "HDAC1" "hsa:3065; Q13547; Q92534" "Androgen receptor signaling pathway; Energy metabolism; Cell cycle; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Neural crest differentiation; Retinoblastoma gene in cancer; Notch signaling; Apoptosis-related network due to altered Notch3 in ovarian cancer; Initiation of transcription and translation elongation at the HIV-1 LTR; MECP2 and associated Rett syndrome; IL6 signaling pathway; TGF-beta signaling pathway; Valproic acid pathway; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; Rett syndrome; Effect of progerin on genes involved in progeria; Ciliary landscape; Transcription co-factors SKI and SKIL protein partners; Overlap between signal transduction pathways contributing to LMNA laminopathies; Opioid receptor pathways; 15q11q13 copy number variation; Notch signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "Potential therapeutics for SARS; SUMOylation of chromatin organization proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Formation of the beta-catenin:TCF transactivating complex; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Regulation of PTEN gene transcription; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; Estrogen-dependent gene expression; MECP2 regulates transcription of neuronal ligands; Factors involved in megakaryocyte development and platelet production; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Downregulation of SMAD2/3:SMAD4 transcriptional activity; RNA Polymerase I Transcription Initiation; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of MECP2 expression and activity; STAT3 nuclear events downstream of ALK signaling; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; G1/S-Specific Transcription; Regulation of TP53 Activity through Acetylation; Transcription of E2F targets under negative control by DREAM complex; Nuclear events stimulated by ALK signaling in cancer; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; MECP2 regulates neuronal receptors and channels; Repression of WNT target genes; Loss of MECP2 binding ability to 5mC-DNA" "56" "3" "0.985" "1.021" "0.955" "1.034" "1.045" "1.063" "1.032" "1.242" "1.992" "1652.4" "1627.6" "1687.2" "1578.0" "1709.3" "1727.1" "1756.9" "1705.8" "2052.2" "3290.8" "" "" "" "" "" "" "" "" "" "" "874.9" "902.4" "966.2" "726.7" "924.8" "960.7" "1034.0" "931.1" "1151.2" "3290.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8225336690214534054" "False" "High" "IsMasterProtein" "O43768" "Alpha-endosulfine OS=Homo sapiens OX=9606 GN=ENSA PE=1 SV=1" "0.000" "False" "28.310" "48" "5" "18" "4" "121" "13.4" "7.24" "57.54" "5" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf04667" "2029" "ENSG00000143420" "ENSA" "A8K1Z9; E9PB69; hsa:2029; O43768; Q5T5H2; Q68D48; Q6FHW0; Q6IAM4; Q6NUL2; Q6VUC6; Q6VUC7; Q6VUC8; Q6VUC9; Q6VUD0; Q6VUD1; Q9NRZ0" "" "MASTL Facilitates Mitotic Progression" "1" "1" "0.925" "0.984" "0.875" "0.910" "0.904" "0.813" "0.844" "0.819" "0.423" "2220.2" "2053.1" "2185.2" "1942.3" "2020.2" "2007.8" "1804.4" "1874.5" "1818.6" "938.6" "" "" "" "" "" "" "" "" "" "" "1175.6" "1138.3" "1251.5" "894.5" "1093.0" "1116.8" "1062.0" "1023.2" "1020.2" "938.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7305935062523076867" "False" "High" "IsMasterProtein" "Q9Y3Z3" "Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 OS=Homo sapiens OX=9606 GN=SAMHD1 PE=1 SV=2" "0.000" "False" "28.289" "13" "8" "11" "8" "626" "72.2" "7.14" "25.21" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01966, Pf07647" "25939" "ENSG00000101347" "SAMHD1" "B4E2A5; E1P5V2; hsa:25939; Q5JXG8; Q8N491; Q9H004; Q9H005; Q9H3U9; Q9Y3Z3" "" "Interferon alpha/beta signaling; Nucleotide catabolism" "2" "0" "1.009" "1.025" "0.985" "0.947" "1.025" "0.912" "0.958" "0.893" "0.638" "743.7" "750.3" "762.3" "732.2" "704.5" "762.2" "678.2" "712.8" "664.2" "474.6" "" "" "" "" "" "" "" "" "" "" "393.8" "416.0" "436.6" "337.2" "381.2" "423.9" "399.2" "389.1" "372.6" "474.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-564768690041684779" "False" "High" "IsMasterProtein" "Q9H0L4" "Cleavage stimulation factor subunit 2 tau variant OS=Homo sapiens OX=9606 GN=CSTF2T PE=1 SV=1" "0.000" "False" "28.287" "14" "7" "10" "2" "616" "64.4" "7.25" "26.53" "7" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf14304, Pf14327" "23283" "ENSG00000177613" "CSTF2T" "B2RAR9; hsa:23283; O75174; Q53HK6; Q7LGE8; Q8N6T1; Q9H0L4" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "1.040" "1.177" "1.004" "1.105" "1.163" "1.086" "1.165" "1.034" "0.872" "84.3" "87.7" "99.2" "84.6" "93.1" "98.0" "91.5" "98.2" "87.1" "73.5" "" "" "" "" "" "" "" "" "" "" "44.6" "48.6" "56.8" "39.0" "50.4" "54.5" "53.9" "53.6" "48.9" "73.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3011469150095823870" "False" "High" "IsMasterProtein" "Q9Y696" "Chloride intracellular channel protein 4 OS=Homo sapiens OX=9606 GN=CLIC4 PE=1 SV=4" "0.000" "False" "28.252" "25" "5" "9" "5" "253" "28.8" "5.59" "25.33" "5" "transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "transporter activity" "Pf13409" "25932" "ENSG00000169504" "CLIC4" "hsa:25932; Q9UFW9; Q9UQJ6; Q9Y696" "" "" "0" "0" "1.090" "1.183" "1.113" "1.080" "1.164" "1.154" "1.109" "1.150" "0.926" "375.1" "408.8" "443.6" "417.6" "405.2" "436.7" "433.0" "416.0" "431.4" "347.2" "" "" "" "" "" "" "" "" "" "" "198.6" "226.6" "254.1" "192.3" "219.2" "242.9" "254.8" "227.1" "242.0" "347.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8165115417245555276" "False" "High" "IsMasterProtein" "Q15293" "Reticulocalbin-1 OS=Homo sapiens OX=9606 GN=RCN1 PE=1 SV=1" "0.000" "False" "28.232" "25" "6" "10" "6" "331" "38.9" "5.00" "30.00" "6" "developmental processes" "ER/Golgi" "other molecular function" "Pf13202" "5954" "ENSG00000049449" "RCN1" "B7Z1M1; D3DR00; hsa:5954; Q15293" "VEGFA-VEGFR2 signaling" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "3" "0" "1.089" "1.078" "1.060" "1.053" "1.020" "1.054" "1.162" "1.041" "0.773" "644.6" "702.1" "694.8" "683.4" "678.7" "657.4" "679.4" "749.1" "671.1" "498.5" "" "" "" "" "" "" "" "" "" "" "341.3" "389.3" "397.9" "314.7" "367.2" "365.7" "399.9" "408.9" "376.5" "498.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6102726942936219024" "False" "High" "IsMasterProtein" "Q14152" "Eukaryotic translation initiation factor 3 subunit A OS=Homo sapiens OX=9606 GN=EIF3A PE=1 SV=1" "0.000" "False" "28.232" "7" "12" "14" "12" "1382" "166.5" "6.79" "32.86" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01399" "8661" "ENSG00000107581" "EIF3A" "B1AMV5; B4DYS1; F5H335; hsa:8661; O00653; Q14152; Q15778" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; NF1 copy number variation syndrome" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition" "9" "0" "1.022" "1.007" "0.993" "1.056" "1.037" "0.952" "0.740" "0.958" "3.179" "861.3" "880.6" "867.2" "855.1" "909.6" "893.3" "820.0" "637.1" "824.8" "2738.2" "" "" "" "" "" "" "" "" "" "" "456.1" "488.2" "496.7" "393.8" "492.1" "496.9" "482.6" "347.8" "462.7" "2738.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4101448346661809879" "False" "High" "IsMasterProtein" "Q15819" "Ubiquitin-conjugating enzyme E2 variant 2 OS=Homo sapiens OX=9606 GN=UBE2V2 PE=1 SV=4" "0.000" "False" "28.142" "42" "6" "21" "4" "145" "16.4" "8.09" "43.14" "6" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf00179" "7336" "ENSG00000169139" "UBE2V2" "hsa:7336; Q15819" "" "Antigen processing: Ubiquitination & Proteasome degradation; E3 ubiquitin ligases ubiquitinate target proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Formation of Incision Complex in GG-NER" "7" "1" "0.977" "1.007" "1.028" "0.966" "0.955" "0.994" "1.024" "0.937" "0.710" "656.7" "641.4" "661.3" "674.9" "634.0" "626.9" "652.9" "672.3" "615.3" "466.3" "" "" "" "" "" "" "" "" "" "" "347.7" "355.6" "378.7" "310.8" "343.0" "348.7" "384.2" "367.0" "345.2" "466.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8263203131680576726" "False" "High" "IsMasterProtein" "Cont_P13717" "Nuclease OS=Serratia marcescens OX=615 GN=nucA PE=1 SV=2" "0.000" "True" "28.135" "23" "6" "9" "6" "266" "28.9" "7.42" "30.49" "6" "" "non-structural extracellular" "nucleic acid binding activity;other molecular function" "Pf01223" "66715254" "" "nucA" "A0A2V4G0H5; A0A5C7C9X8; A0A656VIL2; P13717" "" "" "0" "0" "0.984" "0.947" "1.063" "1.021" "1.054" "1.035" "1.081" "1.027" "0.493" "626.6" "616.6" "593.0" "666.0" "639.9" "660.2" "648.3" "677.3" "643.3" "308.8" "" "" "" "" "" "" "" "" "" "" "331.8" "341.9" "339.6" "306.7" "346.2" "367.2" "381.5" "369.7" "360.9" "308.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5004824679755995217" "False" "High" "IsMasterProtein" "Q13867" "Bleomycin hydrolase OS=Homo sapiens OX=9606 GN=BLMH PE=1 SV=1" "0.000" "False" "28.129" "17" "8" "18" "8" "455" "52.5" "6.27" "49.88" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf03051" "642" "ENSG00000108578" "BLMH" "B2R796; hsa:642; Q13867; Q53F86; Q9UER9" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.964" "0.912" "0.937" "0.950" "0.957" "1.052" "0.963" "0.936" "0.554" "1629.5" "1571.0" "1485.8" "1527.5" "1548.7" "1559.1" "1713.7" "1569.0" "1525.2" "902.7" "" "" "" "" "" "" "" "" "" "" "862.8" "871.0" "850.9" "703.5" "837.9" "867.2" "1008.6" "856.5" "855.6" "902.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2227008394942671266" "False" "High" "IsMasterProtein" "Q9BUQ8" "Probable ATP-dependent RNA helicase DDX23 OS=Homo sapiens OX=9606 GN=DDX23 PE=1 SV=3" "0.000" "False" "28.127" "10" "8" "10" "8" "820" "95.5" "9.55" "18.08" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271" "9416" "ENSG00000174243" "DDX23" "B2R600; B4DH15; hsa:9416; O43188; Q9BUQ8" "" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "2" "0" "1.149" "1.117" "1.137" "1.216" "1.294" "1.152" "1.110" "1.249" "0.704" "768.3" "883.1" "858.6" "873.7" "934.1" "994.5" "885.0" "853.0" "959.5" "540.8" "" "" "" "" "" "" "" "" "" "" "406.8" "489.6" "491.7" "402.4" "505.4" "553.2" "520.9" "465.6" "538.3" "540.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6421674880825804013" "False" "High" "IsMasterProtein" "Q96C19" "EF-hand domain-containing protein D2 OS=Homo sapiens OX=9606 GN=EFHD2 PE=1 SV=1" "0.000" "False" "28.110" "29" "7" "9" "7" "240" "26.7" "5.20" "23.55" "7" "" "other membranes" "other molecular function" "Pf21008" "79180" "ENSG00000142634" "EFHD2" "hsa:79180; Q5JYW9; Q96C19" "" "RHOD GTPase cycle" "1" "0" "1.064" "1.142" "0.999" "1.034" "1.044" "1.069" "1.243" "1.211" "0.824" "1434.3" "1525.8" "1637.5" "1432.9" "1483.2" "1497.6" "1533.1" "1782.4" "1736.4" "1181.5" "" "" "" "" "" "" "" "" "" "" "759.4" "845.9" "937.8" "659.9" "802.5" "833.0" "902.3" "972.9" "974.1" "1181.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9167307694424558965" "False" "High" "IsMasterProtein" "O95336" "6-phosphogluconolactonase OS=Homo sapiens OX=9606 GN=PGLS PE=1 SV=2" "0.000" "False" "28.061" "26" "5" "9" "5" "258" "27.5" "6.05" "24.16" "5" "other metabolic processes" "cytosol" "other molecular function" "Pf01182" "25796" "ENSG00000130313" "PGLS" "hsa:25796; O95336" "Pentose phosphate metabolism" "Pentose phosphate pathway" "2" "0" "0.990" "0.972" "1.139" "1.011" "1.023" "1.024" "1.043" "0.997" "0.654" "358.2" "354.4" "348.0" "407.8" "362.0" "366.5" "366.8" "373.4" "357.0" "234.3" "" "" "" "" "" "" "" "" "" "" "189.6" "196.5" "199.3" "187.8" "195.9" "203.8" "215.9" "203.8" "200.3" "234.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2160825122742080574" "False" "High" "IsMasterProtein" "Q13162" "Peroxiredoxin-4 OS=Homo sapiens OX=9606 GN=PRDX4 PE=1 SV=1" "0.000" "False" "28.038" "21" "6" "28" "4" "271" "30.5" "6.29" "61.90" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00578, Pf10417" "10549" "ENSG00000123131" "PRDX4" "hsa:10549; Q13162; Q6FHT3" "Selenium micronutrient network" "Neutrophil degranulation" "2" "0" "0.923" "0.890" "0.833" "0.908" "1.020" "0.943" "0.888" "0.856" "0.592" "791.7" "731.1" "704.3" "659.5" "718.6" "807.4" "746.7" "702.7" "677.7" "468.4" "" "" "" "" "" "" "" "" "" "" "419.2" "405.4" "403.4" "303.7" "388.8" "449.1" "439.4" "383.6" "380.2" "468.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4988285782465549683" "False" "High" "IsMasterProtein" "Q9NYB0" "Telomeric repeat-binding factor 2-interacting protein 1 OS=Homo sapiens OX=9606 GN=TERF2IP PE=1 SV=1" "0.000" "False" "28.006" "19" "7" "9" "7" "399" "44.2" "4.73" "29.38" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08914, Pf11626, Pf16589" "54386" "ENSG00000166848" "TERF2IP" "B4DQN4; hsa:54386; Q4W4Y2; Q8WYZ3; Q9NWR2; Q9NYB0" "Splicing factor NOVA regulated synaptic proteins; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; Meiotic synapsis; Telomere Extension By Telomerase; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; DNA Damage/Telomere Stress Induced Senescence; Removal of the Flap Intermediate from the C-strand" "16" "0" "1.013" "0.986" "0.887" "0.947" "0.999" "1.075" "0.996" "1.071" "1.534" "951.6" "963.5" "938.7" "844.0" "901.4" "950.2" "1022.7" "947.9" "1019.3" "1459.4" "" "" "" "" "" "" "" "" "" "" "503.8" "534.2" "537.6" "388.7" "487.7" "528.5" "601.9" "517.4" "571.8" "1459.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1633285367868477603" "False" "High" "IsMasterProtein" "P35241" "Radixin OS=Homo sapiens OX=9606 GN=RDX PE=1 SV=1" "0.000" "False" "27.969" "15" "11" "15" "5" "583" "68.5" "6.37" "38.32" "11" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "5962" "ENSG00000137710" "RDX" "A7YIJ8; A7YIK0; A7YIK3; B7Z9U6; F5H1A7; hsa:5962; P35241; Q86Y61" "Regulation of actin cytoskeleton" "Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "4" "1" "0.908" "0.900" "0.832" "0.918" "0.911" "0.946" "0.895" "0.935" "0.453" "1374.7" "1248.9" "1237.1" "1143.3" "1262.1" "1251.9" "1300.2" "1230.1" "1285.6" "622.3" "" "" "" "" "" "" "" "" "" "" "727.9" "692.4" "708.5" "526.5" "682.8" "696.4" "765.2" "671.4" "721.2" "622.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1505271825198651647" "False" "High" "IsMasterProtein" "P41236" "Protein phosphatase inhibitor 2 OS=Homo sapiens OX=9606 GN=PPP1R2 PE=1 SV=2" "0.000" "False" "27.935" "26" "4" "8" "4" "205" "23.0" "4.74" "26.39" "4" "other metabolic processes;other biological processes" "" "enzyme regulator activity;other molecular function" "Pf04979" "5504" "ENSG00000184203" "PPP1R2" "hsa:5504; P41236" "" "" "0" "0" "0.975" "1.099" "1.056" "1.045" "0.979" "1.034" "1.020" "1.028" "0.603" "523.8" "510.7" "575.6" "552.9" "547.5" "512.6" "541.8" "534.1" "538.3" "315.6" "" "" "" "" "" "" "" "" "" "" "277.3" "283.1" "329.7" "254.6" "296.2" "285.1" "318.9" "291.5" "302.0" "315.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3980690536672084448" "False" "High" "IsMasterProtein" "Q8NHV4" "Protein NEDD1 OS=Homo sapiens OX=9606 GN=NEDD1 PE=1 SV=1" "0.000" "False" "27.896" "10" "6" "9" "6" "660" "71.9" "7.97" "32.78" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00400" "121441" "ENSG00000139350" "NEDD1" "B0AZN0; B4E145; G3V3F1; hsa:121441; Q8NA30; Q8NHV4" "" "Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "1.158" "1.166" "1.317" "1.277" "1.141" "1.159" "1.266" "1.074" "0.843" "109.2" "126.4" "127.2" "143.8" "139.4" "124.6" "126.5" "138.2" "117.2" "92.0" "" "" "" "" "" "" "" "" "" "" "57.8" "70.1" "72.9" "66.2" "75.4" "69.3" "74.5" "75.4" "65.7" "92.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3390977729729594241" "False" "High" "IsMasterProtein" "P14735" "Insulin-degrading enzyme OS=Homo sapiens OX=9606 GN=IDE PE=1 SV=4" "0.000" "False" "27.886" "6" "7" "11" "7" "1019" "117.9" "6.61" "28.01" "7" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00675, Pf05193, Pf16187" "3416" "ENSG00000119912" "IDE" "B2R721; B7ZAU2; D3DR35; hsa:3416; P14735; Q5T5N2" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "Peroxisomal protein import; Ub-specific processing proteases; Insulin receptor recycling" "5" "0" "1.141" "0.951" "1.081" "1.182" "1.183" "1.224" "1.230" "1.156" "1.746" "537.9" "613.8" "511.7" "581.4" "635.8" "636.3" "658.2" "661.7" "621.8" "939.3" "" "" "" "" "" "" "" "" "" "" "284.8" "340.3" "293.0" "267.8" "344.0" "354.0" "387.4" "361.2" "348.8" "939.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1619484696952214884" "False" "High" "IsMasterProtein" "P24534" "Elongation factor 1-beta OS=Homo sapiens OX=9606 GN=EEF1B2 PE=1 SV=3" "0.000" "False" "27.881" "30" "6" "13" "5" "225" "24.7" "4.67" "30.67" "6" "protein metabolism;other metabolic processes" "cytosol;other cell component" "enzyme regulator activity;nucleic acid binding activity" "Pf00736, Pf10587" "1933" "ENSG00000114942; ENSG00000283391" "EEF1B2" "A8K795; hsa:1933; P24534; Q6IBH9" "Translation factors" "Eukaryotic Translation Elongation" "2" "0" "0.941" "1.023" "0.998" "0.992" "1.020" "1.004" "0.859" "0.991" "3.253" "745.1" "701.4" "762.6" "744.0" "739.1" "759.7" "748.2" "640.1" "738.8" "2423.7" "" "" "" "" "" "" "" "" "" "" "394.5" "388.9" "436.7" "342.6" "399.9" "422.6" "440.3" "349.4" "414.4" "2423.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3599424746602695209" "False" "High" "IsMasterProtein" "Q9ULE6" "Paladin OS=Homo sapiens OX=9606 GN=PALD1 PE=1 SV=3" "0.000" "False" "27.781" "11" "9" "10" "9" "856" "96.7" "6.54" "27.63" "9" "" "cytosol;other cell component" "other molecular function" "Pf14566" "27143" "ENSG00000107719" "PALD1" "B2RMS1; B9EGC6; hsa:27143; Q5JTK7; Q5JTK8; Q9ULE6" "" "" "0" "0" "1.083" "1.041" "1.026" "1.048" "1.033" "1.009" "1.006" "1.003" "0.858" "862.1" "933.9" "897.2" "884.9" "903.7" "890.8" "869.8" "867.5" "864.7" "739.6" "" "" "" "" "" "" "" "" "" "" "456.5" "517.8" "513.8" "407.5" "488.9" "495.5" "511.9" "473.6" "485.0" "739.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4874670657009698466" "False" "High" "IsMasterProtein" "Q6P2Q9" "Pre-mRNA-processing-splicing factor 8 OS=Homo sapiens OX=9606 GN=PRPF8 PE=1 SV=2" "0.000" "False" "27.766" "4" "11" "11" "11" "2335" "273.4" "8.84" "25.41" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01398, Pf08082, Pf08083, Pf08084, Pf10596, Pf10597, Pf10598, Pf12134" "10594" "ENSG00000174231; ENSG00000274442" "PRPF8" "hsa:10594; O14547; O75965; Q6P2Q9" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "1.061" "0.967" "1.088" "1.019" "1.043" "1.027" "0.793" "0.947" "2.136" "386.3" "409.8" "373.4" "420.4" "393.7" "403.0" "396.6" "306.3" "365.9" "825.0" "" "" "" "" "" "" "" "" "" "" "204.5" "227.2" "213.9" "193.6" "213.0" "224.2" "233.4" "167.2" "205.3" "825.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8882666347281850930" "False" "High" "IsMasterProtein" "P48739" "Phosphatidylinositol transfer protein beta isoform OS=Homo sapiens OX=9606 GN=PITPNB PE=1 SV=2" "0.000" "False" "27.749" "22" "6" "14" "5" "271" "31.5" "6.87" "40.05" "6" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf02121" "23760" "ENSG00000180957" "PITPNB" "B3KYB8; B7Z7Q0; hsa:23760; P48739; Q8N5W1" "" "PI and PC transport between ER and Golgi membranes" "1" "1" "0.938" "1.003" "0.916" "0.994" "0.946" "1.002" "0.944" "1.061" "0.633" "541.4" "507.6" "542.7" "495.6" "537.9" "512.2" "542.6" "511.3" "574.6" "343.0" "" "" "" "" "" "" "" "" "" "" "286.7" "281.4" "310.8" "228.3" "291.0" "284.9" "319.4" "279.1" "322.3" "343.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6669951735420197648" "False" "High" "IsMasterProtein" "O00154" "Cytosolic acyl coenzyme A thioester hydrolase OS=Homo sapiens OX=9606 GN=ACOT7 PE=1 SV=3" "0.000" "False" "27.732" "17" "8" "17" "8" "380" "41.8" "8.54" "43.05" "8" "other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf03061" "11332" "ENSG00000097021" "ACOT7" "A8K0K7; A8K232; A8K6B8; A8K837; B3KQ12; hsa:11332; O00154; O43703; Q53Y78; Q5JYL2; Q5JYL3; Q5JYL4; Q5JYL5; Q5JYL6; Q5TGR4; Q9UJM9; Q9Y539; Q9Y540" "" "Mitochondrial Fatty Acid Beta-Oxidation" "1" "0" "1.018" "1.026" "1.003" "1.038" "1.014" "1.012" "0.950" "1.071" "0.643" "1036.5" "1055.4" "1063.8" "1039.8" "1076.0" "1051.5" "1048.7" "984.3" "1110.5" "666.9" "" "" "" "" "" "" "" "" "" "" "548.8" "585.1" "609.2" "478.9" "582.2" "584.9" "617.2" "537.3" "623.0" "666.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8648350258145669710" "False" "High" "IsMasterProtein" "Q15717" "ELAV-like protein 1 OS=Homo sapiens OX=9606 GN=ELAVL1 PE=1 SV=2" "0.000" "False" "27.723" "20" "6" "9" "6" "326" "36.1" "9.17" "27.53" "6" "cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "1994" "ENSG00000066044" "ELAVL1" "B4DVB8; hsa:1994; Q15717; Q53XN6; Q9BTT1" "AMP-activated protein kinase signaling; Endoderm differentiation; Pre-implantation embryo; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Gastrin signaling pathway; IL-18 signaling pathway; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; 1p36 copy number variation syndrome" "HuR (ELAVL1) binds and stabilizes mRNA" "10" "0" "0.943" "0.993" "1.108" "0.999" "1.035" "1.154" "0.776" "1.176" "6.861" "323.3" "304.8" "320.9" "358.3" "323.0" "334.5" "373.1" "250.7" "380.1" "2218.0" "" "" "" "" "" "" "" "" "" "" "171.2" "169.0" "183.8" "165.0" "174.8" "186.1" "219.6" "136.9" "213.2" "2218.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3985188646102169391" "False" "High" "IsMasterProtein" "P53041" "Serine/threonine-protein phosphatase 5 OS=Homo sapiens OX=9606 GN=PPP5C PE=1 SV=1" "0.000" "False" "27.648" "14" "7" "9" "7" "499" "56.8" "6.28" "23.33" "7" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00149, Pf00515, Pf08321" "5536" "ENSG00000011485" "PPP5C" "hsa:5536; P53041; Q16722; Q53XV2" "MAPK signaling pathway; ATM signaling in development and disease" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Negative regulation of MAPK pathway; ESR-mediated signaling" "5" "0" "0.920" "0.915" "0.761" "0.842" "0.892" "0.882" "0.843" "0.959" "0.701" "554.1" "509.5" "506.8" "421.5" "466.4" "494.2" "488.4" "466.8" "531.1" "388.3" "" "" "" "" "" "" "" "" "" "" "293.4" "282.5" "290.2" "194.1" "252.3" "274.9" "287.5" "254.8" "297.9" "388.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3278234146555232268" "False" "High" "IsMasterProtein" "Q96BK5" "PIN2/TERF1-interacting telomerase inhibitor 1 OS=Homo sapiens OX=9606 GN=PINX1 PE=1 SV=2" "0.000" "False" "27.642" "24" "6" "8" "6" "328" "37.0" "9.60" "22.73" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01585" "54984" "ENSG00000254093; ENSG00000284764" "PINX1" "B2R9B1; hsa:54984; Q548A5; Q6QWG9; Q7Z7J8; Q96BK5; Q96QD7; Q9HBU7; Q9NWW2" "" "" "0" "0" "1.050" "1.083" "1.109" "1.096" "1.146" "1.273" "1.348" "1.260" "0.698" "703.2" "738.0" "761.2" "779.5" "770.9" "805.6" "895.4" "947.9" "885.9" "490.9" "" "" "" "" "" "" "" "" "" "" "372.4" "409.2" "436.0" "359.0" "417.1" "448.1" "527.0" "517.4" "497.0" "490.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8995832376771225777" "False" "High" "IsMasterProtein" "Q9UBS4" "DnaJ homolog subfamily B member 11 OS=Homo sapiens OX=9606 GN=DNAJB11 PE=1 SV=1" "0.000" "False" "27.536" "15" "5" "7" "5" "358" "40.5" "6.18" "21.85" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00226, Pf01556" "51726" "ENSG00000090520" "DNAJB11" "hsa:51726; Q542Y5; Q542Y9; Q6IAQ8; Q96JC6; Q9UBS4" "Photodynamic therapy-induced unfolded protein response" "XBP1(S) activates chaperone genes" "2" "0" "1.058" "1.090" "1.042" "1.096" "1.074" "1.033" "1.095" "1.134" "1.063" "575.1" "608.2" "626.6" "599.2" "630.1" "617.4" "593.8" "629.7" "652.4" "611.3" "" "" "" "" "" "" "" "" "" "" "304.5" "337.2" "358.8" "275.9" "340.9" "343.4" "349.5" "343.7" "366.0" "611.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2662746858814386989" "False" "High" "IsMasterProtein" "Q15024" "Exosome complex component RRP42 OS=Homo sapiens OX=9606 GN=EXOSC7 PE=1 SV=3" "0.000" "False" "27.520" "14" "4" "7" "4" "291" "31.8" "5.19" "15.14" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "23016" "ENSG00000075914" "EXOSC7" "hsa:23016; Q15024; Q96E72" "Ciliary landscape" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "7" "0" "0.963" "0.924" "0.985" "1.016" "1.040" "0.988" "1.058" "0.972" "0.426" "1338.5" "1289.3" "1236.4" "1318.0" "1360.2" "1392.3" "1323.0" "1415.6" "1301.5" "569.7" "" "" "" "" "" "" "" "" "" "" "708.7" "714.8" "708.1" "607.0" "735.9" "774.5" "778.6" "772.7" "730.1" "569.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1560013588739463450" "False" "High" "IsMasterProtein" "Q9H7D7" "WD repeat-containing protein 26 OS=Homo sapiens OX=9606 GN=WDR26 PE=1 SV=3" "0.000" "False" "27.516" "10" "7" "11" "7" "661" "72.1" "6.16" "31.16" "7" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "" "Pf00400, Pf17814" "80232" "ENSG00000162923" "WDR26" "A0MNN3; hsa:80232; Q4G100; Q59EC4; Q5GLZ9; Q86UY4; Q9H3C2; Q9H7D7" "Ciliary landscape" "" "1" "0" "0.997" "0.978" "1.111" "1.058" "1.000" "0.950" "0.962" "0.941" "1.197" "459.9" "458.5" "450.0" "511.1" "486.6" "459.9" "437.0" "442.4" "432.7" "550.5" "" "" "" "" "" "" "" "" "" "" "243.5" "254.2" "257.7" "235.4" "263.3" "255.8" "257.2" "241.5" "242.7" "550.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4607274144029287900" "False" "High" "IsMasterProtein" "O14929" "Histone acetyltransferase type B catalytic subunit OS=Homo sapiens OX=9606 GN=HAT1 PE=1 SV=2" "0.000" "False" "27.483" "15" "5" "8" "5" "419" "49.5" "5.69" "17.16" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf10394, Pf21183" "8520" "ENSG00000128708" "HAT1" "hsa:8520; O14929; Q49A44; Q53QF0; Q53SU4; Q6P594; Q8WWB9" "Ethanol effects on histone modifications" "HATs acetylate histones" "2" "0" "0.988" "1.013" "1.084" "1.044" "1.020" "1.054" "1.018" "1.125" "1.536" "579.0" "572.0" "586.7" "627.6" "604.7" "590.6" "610.2" "589.7" "651.1" "889.0" "" "" "" "" "" "" "" "" "" "" "306.6" "317.2" "336.0" "289.0" "327.2" "328.5" "359.1" "321.9" "365.2" "889.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6575553270224251994" "False" "High" "IsMasterProtein" "P55010" "Eukaryotic translation initiation factor 5 OS=Homo sapiens OX=9606 GN=EIF5 PE=1 SV=2" "0.000" "False" "27.478" "20" "8" "10" "8" "431" "49.2" "5.58" "17.24" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01873, Pf02020" "1983" "ENSG00000100664" "EIF5" "hsa:1983; P55010; Q53XB3; Q9H5N2; Q9UG48" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "4" "0" "0.954" "1.080" "1.037" "1.056" "1.049" "0.961" "0.966" "1.089" "1.528" "580.5" "553.6" "626.9" "602.2" "612.8" "609.0" "557.9" "560.5" "632.5" "886.8" "" "" "" "" "" "" "" "" "" "" "307.4" "307.0" "359.0" "277.3" "331.6" "338.8" "328.3" "306.0" "354.8" "886.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2767928129327746769" "False" "High" "IsMasterProtein" "O14950" "Myosin regulatory light chain 12B OS=Homo sapiens OX=9606 GN=MYL12B PE=1 SV=2" "0.000" "False" "27.429" "41" "7" "13" "7" "172" "19.8" "4.84" "27.67" "7" "other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf08976, Pf13499" "103910; 10627" "ENSG00000118680" "MYL12B" "D3DUH6; hsa:103910; O14950; Q13182; Q7Z5Z4" "Thyroid stimulating hormone (TSH) signaling pathway; Focal adhesion" "RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "9" "0" "0.969" "0.969" "1.069" "0.949" "0.919" "0.890" "0.944" "1.098" "0.672" "889.1" "862.0" "861.8" "950.3" "843.7" "816.7" "791.1" "839.6" "975.9" "597.3" "" "" "" "" "" "" "" "" "" "" "470.8" "477.9" "493.5" "437.7" "456.5" "454.3" "465.6" "458.3" "547.4" "597.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3629072451512354259" "False" "High" "IsMasterProtein" "P52701" "DNA mismatch repair protein Msh6 OS=Homo sapiens OX=9606 GN=MSH6 PE=1 SV=2" "0.000" "False" "27.384" "5" "7" "9" "7" "1360" "152.7" "6.90" "24.98" "7" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00488, Pf00855, Pf01624, Pf05188, Pf05190, Pf05192" "2956" "ENSG00000116062" "MSH6" "B4DF41; B4E3I4; F5H2F9; hsa:2956; O43706; O43917; P52701; Q8TCX4; Q9BTB5" "Glioblastoma signaling pathways; Retinoblastoma gene in cancer; Chromosomal and microsatellite instability in colorectal cancer ; DNA repair pathways, full network; DNA mismatch repair" "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Defective Mismatch Repair Associated With MSH2; Defective Mismatch Repair Associated With MSH6" "8" "0" "0.489" "0.482" "0.468" "0.505" "0.879" "0.496" "0.165" "0.507" "4.658" "503.4" "246.3" "242.4" "235.7" "254.3" "442.3" "249.9" "83.2" "255.2" "2344.7" "" "" "" "" "" "" "" "" "" "" "266.5" "136.6" "138.8" "108.6" "137.6" "246.0" "147.1" "45.4" "143.2" "2344.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4877506006391296740" "False" "High" "IsMasterProtein" "P28072" "Proteasome subunit beta type-6 OS=Homo sapiens OX=9606 GN=PSMB6 PE=1 SV=4" "0.000" "False" "27.305" "23" "6" "14" "6" "239" "25.3" "4.92" "45.55" "6" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00227" "5694" "ENSG00000142507" "PSMB6" "hsa:5694; P28072; Q96J55" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "0.875" "0.923" "0.718" "0.920" "1.001" "0.862" "0.928" "0.900" "0.545" "1353.3" "1183.9" "1249.3" "971.9" "1245.0" "1354.3" "1165.9" "1255.2" "1218.0" "738.2" "" "" "" "" "" "" "" "" "" "" "716.6" "656.4" "715.5" "447.6" "673.6" "753.3" "686.2" "685.2" "683.3" "738.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "144982604897555779" "False" "High" "IsMasterProtein" "P52306" "Rap1 GTPase-GDP dissociation stimulator 1 OS=Homo sapiens OX=9606 GN=RAP1GDS1 PE=1 SV=3" "0.000" "False" "27.236" "9" "6" "12" "5" "607" "66.3" "5.31" "27.18" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion;ER/Golgi;nucleus" "enzyme regulator activity" "Pf00514" "5910" "ENSG00000138698" "RAP1GDS1" "E9PH06; G5E9P9; hsa:5910; P52306; Q499L7; Q4KMV2; Q4QQI8; Q9BUW9; Q9BUX6; Q9NYM2; Q9NZA8" "" "RHOT2 GTPase cycle; RHOT1 GTPase cycle" "2" "0" "1.007" "1.020" "1.130" "1.064" "1.145" "1.106" "0.928" "1.171" "3.068" "254.9" "256.7" "260.0" "288.0" "271.1" "291.9" "281.9" "236.6" "298.4" "781.8" "" "" "" "" "" "" "" "" "" "" "135.0" "142.3" "148.9" "132.6" "146.7" "162.4" "165.9" "129.1" "167.4" "781.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3812741614734953835" "False" "High" "IsMasterProtein" "Q7L9L4" "MOB kinase activator 1B OS=Homo sapiens OX=9606 GN=MOB1B PE=1 SV=3" "0.000" "False" "27.229" "25" "5" "10" "5" "216" "25.1" "6.73" "29.55" "5" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf03637" "92597" "ENSG00000173542" "MOB1B" "B2R8U6; B4DRY3; hsa:92597; Q7L9L4; Q8IY23" "Pleural mesothelioma" "Signaling by Hippo" "2" "0" "1.047" "1.041" "0.955" "1.027" "1.053" "0.970" "1.057" "1.073" "0.772" "1081.3" "1132.2" "1125.8" "1032.9" "1110.8" "1138.1" "1048.4" "1142.8" "1160.3" "834.6" "" "" "" "" "" "" "" "" "" "" "572.6" "627.7" "644.8" "475.7" "601.0" "633.1" "617.0" "623.8" "650.9" "834.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5990763445808986334" "False" "High" "IsMasterProtein" "O75083" "WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=WDR1 PE=1 SV=4" "0.000" "False" "27.175" "11" "6" "9" "6" "606" "66.2" "6.65" "28.39" "6" "cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00400" "9948" "ENSG00000071127" "WDR1" "A8K6E9; A8MPU4; hsa:9948; O75083; O75313; Q8N6E5; Q9UG05; Q9UG78; Q9UQE0" "Hypertrophy model" "Platelet degranulation" "2" "0" "0.951" "0.943" "0.848" "0.936" "0.997" "0.914" "0.954" "0.954" "0.870" "1131.7" "1076.3" "1067.4" "959.5" "1059.2" "1128.2" "1034.2" "1079.2" "1079.4" "985.0" "" "" "" "" "" "" "" "" "" "" "599.2" "596.8" "611.3" "441.9" "573.1" "627.6" "608.7" "589.1" "605.5" "985.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-100353375695918439" "False" "High" "IsMasterProtein" "P53999" "Activated RNA polymerase II transcriptional coactivator p15 OS=Homo sapiens OX=9606 GN=SUB1 PE=1 SV=3" "0.000" "False" "27.153" "30" "3" "17" "3" "127" "14.4" "9.60" "46.89" "3" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02229" "10923" "ENSG00000113387" "SUB1" "hsa:10923; P53999; Q96L29" "" "" "0" "0" "0.979" "1.052" "0.970" "0.933" "0.929" "1.048" "1.077" "1.045" "0.546" "2053.3" "2011.0" "2160.7" "1992.6" "1915.7" "1908.0" "2151.1" "2211.4" "2146.4" "1121.6" "" "" "" "" "" "" "" "" "" "" "1087.2" "1115.0" "1237.4" "917.7" "1036.5" "1061.3" "1266.0" "1207.1" "1204.1" "1121.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2958719848471143183" "False" "High" "IsMasterProtein" "P54687" "Branched-chain-amino-acid aminotransferase, cytosolic OS=Homo sapiens OX=9606 GN=BCAT1 PE=1 SV=3" "0.000" "False" "27.131" "17" "6" "17" "6" "386" "42.9" "5.30" "48.21" "6" "cell cycle OR cell proliferation;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf01063" "586" "ENSG00000060982" "BCAT1" "B3KY27; B7Z2M5; B7Z5L0; F5H5E4; hsa:586; P54687; Q68DQ7; Q96MY9" "Trans-sulfuration, one-carbon metabolism and related pathways; Amino acid metabolism; One-carbon metabolism and related pathways" "Branched-chain amino acid catabolism" "4" "0" "0.966" "1.074" "0.907" "0.909" "0.971" "1.066" "0.991" "0.979" "0.563" "917.7" "886.1" "985.4" "831.9" "834.0" "890.9" "977.9" "909.0" "898.4" "517.0" "" "" "" "" "" "" "" "" "" "" "485.9" "491.3" "564.3" "383.1" "451.2" "495.6" "575.5" "496.2" "504.0" "517.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2329486021897558917" "False" "High" "IsMasterProtein" "P78347" "General transcription factor II-I OS=Homo sapiens OX=9606 GN=GTF2I PE=1 SV=2" "0.000" "False" "27.040" "7" "6" "10" "6" "998" "112.3" "6.39" "26.43" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02946" "2969" "ENSG00000263001" "GTF2I" "hsa:2969; O14743; O15359; O43546; O43588; O43589; P78347; Q75M85; Q75M86; Q75M87; Q75M88; Q86U51; Q9BSZ4" "B cell receptor signaling pathway; 7q11.23 copy number variation syndrome; Genetic causes of porto-sinusoidal vascular disease" "" "3" "0" "1.051" "1.060" "1.187" "1.167" "1.203" "1.189" "0.500" "1.248" "10.582" "406.3" "427.2" "430.7" "482.2" "474.0" "488.9" "483.0" "203.1" "506.9" "4299.4" "" "" "" "" "" "" "" "" "" "" "215.1" "236.8" "246.6" "222.1" "256.5" "272.0" "284.3" "110.8" "284.3" "4299.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3099345167640791747" "False" "High" "IsMasterProtein" "Q00796" "Sorbitol dehydrogenase OS=Homo sapiens OX=9606 GN=SORD PE=1 SV=4" "0.000" "False" "27.040" "18" "6" "14" "6" "357" "38.3" "7.97" "38.54" "6" "other metabolic processes;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion" "other molecular function" "Pf00107, Pf08240" "6652" "ENSG00000140263" "SORD" "B2R655; B7Z3A6; hsa:6652; J3JZZ5; Q00796; Q16682; Q9UMD6" "Disorders of fructose metabolism; Polyol pathway" "Formation of xylulose-5-phosphate; Fructose biosynthesis" "4" "0" "0.969" "0.959" "1.002" "0.944" "0.960" "0.996" "0.895" "0.939" "0.651" "1460.4" "1415.4" "1401.0" "1463.9" "1378.2" "1401.7" "1454.2" "1307.2" "1372.0" "950.5" "" "" "" "" "" "" "" "" "" "" "773.3" "784.7" "802.3" "674.2" "745.7" "779.7" "855.8" "713.6" "769.7" "950.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5857120018545354279" "False" "High" "IsMasterProtein" "Q8NFH3" "Nucleoporin Nup43 OS=Homo sapiens OX=9606 GN=NUP43 PE=1 SV=1" "0.000" "False" "27.020" "19" "6" "6" "6" "380" "42.1" "5.63" "18.16" "6" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00400" "348995" "ENSG00000120253" "NUP43" "B4E2F0; hsa:348995; Q8NFH3; Q9H8S0" "" "Separation of Sister Chromatids; Regulation of HSF1-mediated heat shock response; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; RHO GTPases Activate Formins; HCMV Late Events; Resolution of Sister Chromatid Cohesion; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "35" "0" "1.094" "0.939" "1.077" "1.101" "1.094" "1.098" "1.164" "1.150" "0.834" "287.3" "314.3" "269.7" "309.4" "316.4" "314.2" "315.4" "334.5" "330.4" "239.7" "" "" "" "" "" "" "" "" "" "" "152.1" "174.2" "154.4" "142.5" "171.2" "174.8" "185.6" "182.6" "185.4" "239.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7186431258293956911" "False" "High" "IsMasterProtein" "Q04837" "Single-stranded DNA-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=SSBP1 PE=1 SV=1" "0.000" "False" "27.001" "33" "5" "11" "5" "148" "17.2" "9.60" "32.35" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00436" "6742" "ENSG00000106028; ENSG00000262771" "SSBP1" "hsa:6742; Q04837" "" "Mitochondrial protein degradation; Transcriptional activation of mitochondrial biogenesis" "2" "0" "0.952" "1.015" "0.876" "0.954" "0.940" "0.851" "0.862" "0.850" "0.414" "2480.4" "2361.4" "2517.3" "2171.6" "2366.6" "2330.4" "2112.0" "2138.5" "2109.0" "1027.4" "" "" "" "" "" "" "" "" "" "" "1313.4" "1309.2" "1441.7" "1000.1" "1280.4" "1296.3" "1243.0" "1167.3" "1183.1" "1027.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6692075332981007833" "False" "High" "IsMasterProtein" "Q13451" "Peptidyl-prolyl cis-trans isomerase FKBP5 OS=Homo sapiens OX=9606 GN=FKBP5 PE=1 SV=2" "0.000" "False" "26.924" "13" "6" "8" "6" "457" "51.2" "5.90" "21.73" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00254, Pf00515" "2289" "ENSG00000096060" "FKBP5" "F5H7R1; hsa:2289; Q13451; Q59EB8; Q5TGM6" "Androgen receptor network in prostate cancer; Farnesoid X receptor pathway; Nuclear receptors meta-pathway; MECP2 and associated Rett syndrome" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; ESR-mediated signaling; MECP2 regulates neuronal receptors and channels" "7" "0" "1.041" "1.052" "1.091" "1.103" "1.112" "1.081" "0.645" "1.092" "6.744" "342.5" "356.4" "360.1" "373.6" "377.6" "381.0" "370.3" "221.0" "373.9" "2309.5" "" "" "" "" "" "" "" "" "" "" "181.3" "197.6" "206.3" "172.1" "204.3" "211.9" "217.9" "120.7" "209.8" "2309.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8256721828910616389" "False" "High" "IsMasterProtein" "P55196" "Afadin OS=Homo sapiens OX=9606 GN=AFDN PE=1 SV=3" "0.000" "False" "26.906" "4" "7" "8" "7" "1824" "206.7" "6.47" "21.12" "7" "cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00498, Pf00595, Pf00788, Pf01843" "4301" "ENSG00000130396" "AFDN" "O75087; O75088; O75089; P55196; Q59FP0; Q5TIG6; Q5TIG7; Q9NSN7; Q9NU92" "VEGFA-VEGFR2 signaling; Ras signaling; 1q21.1 copy number variation syndrome" "" "3" "0" "1.036" "1.030" "1.011" "1.082" "1.044" "1.205" "1.143" "1.208" "1.665" "538.8" "558.1" "555.1" "544.8" "583.1" "562.5" "649.3" "615.9" "651.2" "897.3" "" "" "" "" "" "" "" "" "" "" "285.3" "309.4" "317.9" "250.9" "315.5" "312.9" "382.1" "336.2" "365.3" "897.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8439683798465219975" "False" "High" "IsMasterProtein" "P08621" "U1 small nuclear ribonucleoprotein 70 kDa OS=Homo sapiens OX=9606 GN=SNRNP70 PE=1 SV=2" "0.000" "False" "26.886" "15" "7" "9" "7" "437" "51.5" "9.94" "24.43" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf12220" "6625" "ENSG00000104852" "SNRNP70" "B3KUA3; hsa:6625; P08621; P78493; P78494; Q15364; Q15686; Q15687; Q15689; Q99377; Q9UE45; Q9UE46; Q9UE47; Q9UE48; Q9UFQ6" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.081" "1.181" "1.010" "1.098" "1.035" "1.030" "0.937" "1.213" "1.630" "1091.5" "1180.2" "1289.3" "1102.3" "1198.2" "1129.9" "1123.8" "1022.3" "1324.2" "1778.9" "" "" "" "" "" "" "" "" "" "" "577.9" "654.4" "738.4" "507.7" "648.3" "628.5" "661.4" "558.0" "742.8" "1778.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7321680242331923571" "False" "High" "IsMasterProtein" "Q96EI5" "Transcription elongation factor A protein-like 4 OS=Homo sapiens OX=9606 GN=TCEAL4 PE=1 SV=2" "0.000" "False" "26.805" "31" "6" "11" "6" "215" "24.6" "5.20" "28.42" "6" "" "nucleus" "" "Pf04538" "79921" "ENSG00000133142" "TCEAL4" "hsa:79921; Q8WY12; Q96EI5; Q9H2H1; Q9H775" "" "" "0" "0" "1.023" "1.046" "1.081" "0.943" "0.977" "0.981" "1.045" "0.936" "0.612" "792.6" "810.4" "828.8" "856.7" "747.4" "774.2" "777.8" "828.2" "741.7" "484.9" "" "" "" "" "" "" "" "" "" "" "419.7" "449.3" "474.7" "394.5" "404.4" "430.6" "457.8" "452.1" "416.1" "484.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7367615421387894087" "False" "High" "IsMasterProtein" "Q9Y5X3" "Sorting nexin-5 OS=Homo sapiens OX=9606 GN=SNX5 PE=1 SV=1" "0.000" "False" "26.788" "19" "8" "10" "7" "404" "46.8" "6.76" "29.88" "8" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00787, Pf09325" "27131" "ENSG00000089006" "SNX5" "B7ZKN3; D3DW26; hsa:27131; Q52LC4; Q7KZN0; Q9BWP0; Q9Y5X3" "" "Golgi Associated Vesicle Biogenesis" "1" "1" "0.956" "0.937" "0.976" "0.971" "0.967" "0.879" "0.886" "0.831" "1.228" "2155.0" "2059.9" "2018.5" "2104.3" "2093.1" "2083.7" "1894.7" "1910.2" "1791.7" "2646.1" "" "" "" "" "" "" "" "" "" "" "1141.1" "1142.1" "1156.0" "969.1" "1132.4" "1159.1" "1115.1" "1042.7" "1005.1" "2646.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7680692845404357414" "False" "High" "IsMasterProtein" "P30085" "UMP-CMP kinase OS=Homo sapiens OX=9606 GN=CMPK1 PE=1 SV=3" "0.000" "False" "26.781" "18" "4" "9" "4" "196" "22.2" "5.57" "28.91" "4" "other metabolic processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00406" "51727" "ENSG00000162368" "CMPK1" "B2R6S5; B4DPU7; E9PGI8; hsa:51727; P30085; Q53GB7; Q5SVZ0; Q96C07; Q9UBQ8; Q9UIA2" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "1.053" "1.037" "0.964" "0.999" "1.042" "0.830" "0.991" "0.983" "0.694" "1074.5" "1131.1" "1114.3" "1035.8" "1073.9" "1119.7" "891.4" "1065.3" "1056.5" "745.5" "" "" "" "" "" "" "" "" "" "" "569.0" "627.1" "638.2" "477.0" "581.0" "622.8" "524.6" "581.5" "592.7" "745.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1999315358904826558" "False" "High" "IsMasterProtein" "P01040" "Cystatin-A OS=Homo sapiens OX=9606 GN=CSTA PE=1 SV=1" "0.000" "False" "26.761" "53" "5" "8" "5" "98" "11.0" "5.50" "25.89" "5" "cell adhesion;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00031" "1475" "ENSG00000121552" "CSTA" "hsa:1475; P01040; Q6IB90" "8p23.1 copy number variation syndrome" "Formation of the cornified envelope" "2" "0" "0.843" "1.067" "0.807" "0.906" "0.893" "0.873" "0.862" "0.959" "0.585" "1410.9" "1189.1" "1506.0" "1138.7" "1278.6" "1259.4" "1232.0" "1215.8" "1353.1" "825.4" "" "" "" "" "" "" "" "" "" "" "747.1" "659.3" "862.5" "524.4" "691.7" "700.5" "725.1" "663.7" "759.1" "825.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9007113237130658680" "False" "High" "IsMasterProtein" "O15498" "Synaptobrevin homolog YKT6 OS=Homo sapiens OX=9606 GN=YKT6 PE=1 SV=1" "0.000" "False" "26.685" "29" "6" "9" "6" "198" "22.4" "6.92" "23.23" "6" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00957, Pf13774" "10652" "ENSG00000106636" "YKT6" "B4DR94; hsa:10652; O15498; Q53F01; Q6FGU9; Q6IB15" "" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; COPI-mediated anterograde transport; RAC3 GTPase cycle; Intra-Golgi traffic; COPII-mediated vesicle transport" "8" "0" "1.063" "1.040" "0.968" "1.006" "0.975" "1.023" "1.113" "1.015" "0.620" "688.3" "731.8" "715.5" "666.3" "692.3" "670.8" "704.4" "766.3" "698.4" "426.8" "" "" "" "" "" "" "" "" "" "" "364.4" "405.7" "409.7" "306.9" "374.5" "373.1" "414.6" "418.3" "391.8" "426.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "714954485545523239" "False" "High" "IsMasterProtein" "P27986" "Phosphatidylinositol 3-kinase regulatory subunit alpha OS=Homo sapiens OX=9606 GN=PIK3R1 PE=1 SV=2" "0.000" "False" "26.683" "11" "8" "8" "8" "724" "83.5" "6.16" "23.27" "8" "cell adhesion;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf00017, Pf00620, Pf16454" "5295" "ENSG00000145675" "PIK3R1" "B3KT19; D3DWA0; E7EX19; hsa:5295; P27986; Q15747; Q4VBZ7; Q53EM6; Q8IXA2; Q8N1C5" "IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Apoptosis; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; PDGFR-beta pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Overview of interferons-mediated signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; IL-18 signaling pathway; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; TROP2 regulatory signaling; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; 5q35 copy number variation; Interferon type I signaling pathways; Notch signaling pathway; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "G alpha (q) signalling events; Extra-nuclear estrogen signaling; RAC2 GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; RAF/MAP kinase cascade; PI3K Cascade; PI-3K cascade:FGFR4; Signaling by FGFR4 in disease; Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; RHOC GTPase cycle; Downstream TCR signaling; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants; RHOU GTPase cycle; Synthesis of PIPs at the plasma membrane; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL; Nephrin family interactions; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; VEGFA-VEGFR2 Pathway; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle; Interleukin-4 and Interleukin-13 signaling; PI3K events in ERBB4 signaling; PI3K events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; GAB1 signalosome; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; Signaling by CSF1 (M-CSF) in myeloid cells; PI-3K cascade:FGFR1; PI-3K cascade:FGFR2; Signaling by FGFR2 in disease; PI-3K cascade:FGFR3; Signaling by FGFR3 in disease; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; GP1b-IX-V activation signalling; MET activates PI3K/AKT signaling; Activated NTRK3 signals through PI3K; Activated NTRK2 signals through PI3K" "154" "0" "1.137" "1.139" "1.174" "1.153" "1.243" "1.077" "1.035" "1.139" "2.098" "402.9" "458.1" "459.0" "472.9" "464.7" "501.0" "433.9" "417.1" "459.1" "845.3" "" "" "" "" "" "" "" "" "" "" "213.4" "254.0" "262.9" "217.8" "251.4" "278.7" "255.4" "227.7" "257.5" "845.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8415712224574136193" "False" "High" "IsMasterProtein" "P26196" "Probable ATP-dependent RNA helicase DDX6 OS=Homo sapiens OX=9606 GN=DDX6 PE=1 SV=2" "0.000" "False" "26.644" "16" "7" "12" "7" "483" "54.4" "8.66" "32.18" "7" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1656" "ENSG00000110367" "DDX6" "hsa:1656; P26196; Q5D048" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "1.047" "0.964" "1.065" "1.084" "1.087" "1.116" "1.090" "1.017" "0.995" "837.7" "876.8" "807.6" "892.5" "908.2" "910.5" "935.3" "913.4" "851.7" "833.3" "" "" "" "" "" "" "" "" "" "" "443.6" "486.1" "462.5" "411.0" "491.3" "506.4" "550.4" "498.6" "477.8" "833.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8491275537287957660" "False" "High" "IsMasterProtein" "Q8NDD1" "Uncharacterized protein C1orf131 OS=Homo sapiens OX=9606 GN=C1orf131 PE=1 SV=4" "0.000" "False" "26.613" "17" "5" "7" "5" "293" "32.6" "9.88" "22.00" "5" "other biological processes" "nucleus;other cell component" "" "Pf15375" "128061" "ENSG00000143633" "C1orf131" "Q5TBI0; Q5TBI1; Q6P6B4; Q7Z6H5; Q8N432; Q8NDD1; Q96NM6" "" "" "0" "0" "1.087" "1.145" "1.067" "1.096" "1.080" "0.998" "1.117" "1.160" "0.594" "470.6" "511.5" "538.8" "502.1" "515.6" "508.1" "469.6" "525.5" "546.1" "279.3" "" "" "" "" "" "" "" "" "" "" "249.2" "283.6" "308.6" "231.2" "279.0" "282.6" "276.4" "286.8" "306.3" "279.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2706346813500612186" "False" "High" "IsMasterProtein" "Q9C0C9" "(E3-independent) E2 ubiquitin-conjugating enzyme OS=Homo sapiens OX=9606 GN=UBE2O PE=1 SV=3" "0.000" "False" "26.604" "5" "7" "11" "7" "1292" "141.2" "5.12" "25.05" "7" "protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "63893" "ENSG00000175931" "UBE2O" "A6NDU5; hsa:63893; Q69YP4; Q6PIZ2; Q86UA4; Q8N425; Q8TBN1; Q9BSW1; Q9C0C9; Q9H6E6; Q9H7E4; Q9H9B2" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.165" "1.060" "1.175" "1.081" "1.077" "1.134" "1.010" "1.081" "1.418" "461.0" "537.0" "488.8" "541.6" "498.2" "496.5" "522.6" "465.6" "498.3" "653.5" "" "" "" "" "" "" "" "" "" "" "244.1" "297.8" "279.9" "249.4" "269.6" "276.2" "307.6" "254.1" "279.5" "653.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4518810540954697302" "False" "High" "IsMasterProtein" "Q8TAT6" "Nuclear protein localization protein 4 homolog OS=Homo sapiens OX=9606 GN=NPLOC4 PE=1 SV=3" "0.000" "False" "26.595" "10" "5" "7" "5" "608" "68.1" "6.38" "27.35" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf05020, Pf05021, Pf11543" "55666" "ENSG00000182446" "NPLOC4" "hsa:55666; Q8N3J1; Q8TAT6; Q9H8V2; Q9H964; Q9NWR5; Q9P229" "" "KEAP1-NFE2L2 pathway; Neddylation; Translesion Synthesis by POLH" "3" "0" "0.998" "0.959" "0.959" "1.029" "1.044" "1.025" "0.953" "0.984" "0.893" "768.4" "766.7" "736.7" "737.2" "790.8" "802.0" "787.8" "732.3" "756.0" "685.9" "" "" "" "" "" "" "" "" "" "" "406.9" "425.1" "421.9" "339.5" "427.9" "446.1" "463.6" "399.7" "424.1" "685.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6456635449604072928" "False" "High" "IsMasterProtein" "P30419" "Glycylpeptide N-tetradecanoyltransferase 1 OS=Homo sapiens OX=9606 GN=NMT1 PE=1 SV=2" "0.000" "False" "26.571" "11" "5" "8" "5" "496" "56.8" "7.80" "25.58" "5" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf01233, Pf02799" "4836" "ENSG00000136448" "NMT1" "A8K7C1; hsa:4836; P30419; Q9UE09" "" "Inactivation, recovery and regulation of the phototransduction cascade; Late Phase of HIV Life Cycle; Activation, myristolyation of BID and translocation to mitochondria" "3" "0" "0.953" "1.019" "0.969" "0.981" "0.966" "0.996" "1.043" "0.927" "0.561" "1293.8" "1233.0" "1317.8" "1253.2" "1269.4" "1249.7" "1288.0" "1350.0" "1199.2" "726.1" "" "" "" "" "" "" "" "" "" "" "685.1" "683.6" "754.7" "577.1" "686.8" "695.1" "758.1" "736.9" "672.7" "726.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-990721738298047914" "False" "High" "IsMasterProtein" "O00299" "Chloride intracellular channel protein 1 OS=Homo sapiens OX=9606 GN=CLIC1 PE=1 SV=4" "0.000" "False" "26.536" "22" "6" "12" "6" "241" "26.9" "5.17" "36.70" "6" "transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;mitochondrion;ER/Golgi;nucleus;other cell component" "transporter activity" "Pf13409, Pf13410" "1192" "ENSG00000206394; ENSG00000213719; ENSG00000223639; ENSG00000226248; ENSG00000226417; ENSG00000226651; ENSG00000230685" "CLIC1" "hsa:1192; O00299; Q15089; Q502X1" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.121" "1.111" "1.172" "0.833" "0.920" "0.905" "1.082" "0.893" "0.797" "1362.2" "1526.4" "1513.7" "1596.3" "1134.5" "1252.9" "1233.3" "1473.9" "1216.0" "1086.2" "" "" "" "" "" "" "" "" "" "" "721.3" "846.3" "866.9" "735.1" "613.8" "696.9" "725.8" "804.5" "682.1" "1086.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8506961570143965113" "False" "High" "IsMasterProtein" "Q99497" "Parkinson disease protein 7 OS=Homo sapiens OX=9606 GN=PARK7 PE=1 SV=2" "0.000" "False" "26.516" "36" "7" "16" "7" "189" "19.9" "6.79" "46.41" "7" "cell-cell signaling;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01965" "11315" "ENSG00000116288" "PARK7" "B2R4Z1; hsa:11315; O14805; Q6DR95; Q7LFU2; Q99497" "Androgen receptor signaling pathway; Synaptic vesicle pathway; Parkinson's disease pathway; HDAC6 interactions in the central nervous system" "Late endosomal microautophagy; Aggrephagy; SUMOylation of transcription cofactors; Chaperone Mediated Autophagy" "8" "0" "0.943" "0.974" "0.915" "0.968" "1.006" "1.024" "0.967" "1.030" "0.666" "1477.6" "1393.1" "1438.7" "1351.6" "1429.9" "1486.3" "1512.4" "1428.2" "1521.8" "984.0" "" "" "" "" "" "" "" "" "" "" "782.4" "772.4" "823.9" "622.5" "773.7" "826.8" "890.1" "779.6" "853.7" "984.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3851327045355939363" "False" "High" "IsMasterProtein" "P16401" "Histone H1.5 OS=Homo sapiens OX=9606 GN=H1-5 PE=1 SV=3" "0.000" "False" "26.504" "17" "4" "15" "2" "226" "22.6" "10.92" "45.55" "4" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3009" "ENSG00000184357" "H1-5" "hsa:3009; P16401; Q14529; Q3MJ42" "" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "2" "0" "1.124" "1.208" "1.022" "0.974" "1.083" "1.075" "1.200" "1.257" "0.761" "527.2" "592.7" "636.9" "538.9" "513.4" "571.1" "566.7" "632.6" "662.7" "401.2" "" "" "" "" "" "" "" "" "" "" "279.2" "328.6" "364.7" "248.2" "277.8" "317.7" "333.5" "345.3" "371.7" "401.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8008274239603490952" "False" "High" "IsMasterProtein" "P51991" "Heterogeneous nuclear ribonucleoprotein A3 OS=Homo sapiens OX=9606 GN=HNRNPA3 PE=1 SV=2" "0.000" "False" "26.501" "20" "8" "21" "5" "378" "39.6" "9.01" "55.09" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "220988" "ENSG00000170144" "HNRNPA3" "D3DPF4; hsa:220988; P51991; Q53RW7; Q6URK5" "" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "2" "0" "0.982" "1.004" "1.127" "1.057" "1.022" "0.998" "0.983" "0.987" "1.742" "414.7" "407.3" "416.1" "467.1" "438.3" "423.7" "413.8" "407.6" "409.4" "722.2" "" "" "" "" "" "" "" "" "" "" "219.6" "225.8" "238.3" "215.1" "237.1" "235.7" "243.5" "222.5" "229.7" "722.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5557556089384344895" "False" "High" "IsMasterProtein" "Q9UN86" "Ras GTPase-activating protein-binding protein 2 OS=Homo sapiens OX=9606 GN=G3BP2 PE=1 SV=2" "0.000" "False" "26.470" "15" "8" "18" "8" "482" "54.1" "5.55" "35.52" "8" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf02136" "9908" "ENSG00000138757" "G3BP2" "A8K6X1; hsa:9908; O60606; O75149; Q9UN86; Q9UPA1" "" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "1" "0" "1.008" "1.050" "0.992" "1.009" "1.001" "0.925" "0.991" "0.995" "1.090" "1846.9" "1861.5" "1939.2" "1831.8" "1864.2" "1848.8" "1709.2" "1830.3" "1837.6" "2013.6" "" "" "" "" "" "" "" "" "" "" "978.0" "1032.1" "1110.6" "843.6" "1008.6" "1028.4" "1005.9" "999.1" "1030.8" "2013.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5357414389544456501" "False" "High" "IsMasterProtein" "P55212" "Caspase-6 OS=Homo sapiens OX=9606 GN=CASP6 PE=1 SV=2" "0.000" "False" "26.462" "21" "5" "5" "4" "293" "33.3" "6.93" "16.20" "5" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00656" "839" "ENSG00000138794" "CASP6" "hsa:839; P55212; Q9BQE7" "Parkinson's disease pathway; Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Acute viral myocarditis" "TP53 Regulates Transcription of Caspase Activators and Caspases; Caspase-mediated cleavage of cytoskeletal proteins; Breakdown of the nuclear lamina" "10" "0" "1.046" "0.956" "0.939" "0.967" "1.026" "0.853" "0.877" "0.828" "0.655" "437.3" "457.3" "418.2" "410.4" "422.9" "448.7" "373.0" "383.6" "362.0" "286.5" "" "" "" "" "" "" "" "" "" "" "231.5" "253.5" "239.5" "189.0" "228.8" "249.6" "219.5" "209.4" "203.1" "286.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2128989799875943394" "False" "High" "IsMasterProtein" "Q92888" "Rho guanine nucleotide exchange factor 1 OS=Homo sapiens OX=9606 GN=ARHGEF1 PE=1 SV=2" "0.000" "False" "26.454" "7" "6" "8" "6" "912" "102.4" "5.66" "25.67" "6" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf00621, Pf09128, Pf17838" "9138" "ENSG00000076928" "ARHGEF1" "hsa:9138; O00513; Q6NX52; Q8N4J4; Q92888; Q96BF4; Q96F17; Q9BSB1" "G protein signaling pathways; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "RHOC GTPase cycle; RHOA GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOB GTPase cycle" "9" "0" "1.237" "1.022" "1.376" "1.410" "1.055" "1.183" "1.276" "1.067" "1.382" "19.1" "23.6" "19.5" "26.2" "26.9" "20.1" "22.6" "24.3" "20.3" "26.4" "" "" "" "" "" "" "" "" "" "" "10.1" "13.1" "11.2" "12.1" "14.5" "11.2" "13.3" "13.3" "11.4" "26.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8586713697824146806" "False" "High" "IsMasterProtein" "P46379" "Large proline-rich protein BAG6 OS=Homo sapiens OX=9606 GN=BAG6 PE=1 SV=2" "0.000" "False" "26.450" "7" "6" "7" "6" "1132" "119.3" "5.60" "18.83" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;translation activity;other molecular function" "Pf00240, Pf12057, Pf20960" "7917" "ENSG00000096155; ENSG00000204463; ENSG00000227761; ENSG00000228760; ENSG00000229524; ENSG00000233348; ENSG00000234651" "BAG6" "A2ADJ7; A3KQ42; A3KQ44; A6NGY6; A6PWF7; B0UX84; B4DZ12; B4E3V4; E7EMZ4; F8VXY4; hsa:7917; O95874; P46379; Q5HYL9; Q5SQ35; Q5SQ36; Q5SQ37; Q5SQ41; Q5SRP8; Q5SRP9; Q5STC1; Q5STX1; Q5STX3; Q96SA6; Q9BCN4" "" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "1" "0" "1.053" "1.038" "1.185" "1.115" "1.118" "1.255" "1.143" "1.204" "1.092" "288.9" "304.2" "299.9" "342.3" "322.1" "323.0" "362.7" "330.1" "347.7" "315.6" "" "" "" "" "" "" "" "" "" "" "153.0" "168.7" "171.8" "157.6" "174.3" "179.7" "213.5" "180.2" "195.1" "315.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8716615983158352243" "False" "High" "IsMasterProtein" "P27695" "DNA repair nuclease/redox regulator APEX1 OS=Homo sapiens OX=9606 GN=APEX1 PE=1 SV=2" "0.000" "False" "26.391" "15" "4" "5" "4" "318" "35.5" "8.12" "18.22" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03372" "328" "ENSG00000100823; ENSG00000291796" "APEX1" "hsa:328; P27695; Q969L5; Q99775" "Thyroid stimulating hormone (TSH) signaling pathway; Spinal cord injury; Base excision repair; DNA repair pathways, full network" "Displacement of DNA glycosylase by APEX1; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Abasic sugar-phosphate removal via the single-nucleotide replacement pathway" "10" "0" "0.913" "0.918" "0.832" "0.976" "1.001" "0.802" "0.737" "0.816" "2.381" "510.6" "466.4" "468.6" "424.6" "498.2" "511.4" "409.5" "376.3" "416.8" "1215.7" "" "" "" "" "" "" "" "" "" "" "270.4" "258.6" "268.4" "195.6" "269.6" "284.4" "241.0" "205.4" "233.8" "1215.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2851468461982241185" "False" "High" "IsMasterProtein" "P30626" "Sorcin OS=Homo sapiens OX=9606 GN=SRI PE=1 SV=1" "0.000" "False" "26.379" "26" "5" "9" "5" "198" "21.7" "5.59" "26.22" "5" "transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf13499, Pf13833" "6717" "ENSG00000075142" "SRI" "A8MTH6; B4DKK2; D6W5Q0; hsa:6717; P30626" "" "Stimuli-sensing channels; Ion homeostasis; Ion transport by P-type ATPases; Reduction of cytosolic Ca++ levels; Sodium/Calcium exchangers" "5" "0" "1.007" "0.989" "1.011" "1.032" "0.968" "0.992" "1.081" "1.007" "0.585" "918.1" "924.4" "908.4" "928.0" "947.9" "888.5" "910.7" "992.6" "924.2" "537.0" "" "" "" "" "" "" "" "" "" "" "486.1" "512.5" "520.3" "427.4" "512.9" "494.2" "536.0" "541.8" "518.5" "537.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1695167521897825927" "False" "High" "IsMasterProtein" "P53609" "Geranylgeranyl transferase type-1 subunit beta OS=Homo sapiens OX=9606 GN=PGGT1B PE=1 SV=2" "0.000" "False" "26.372" "21" "8" "10" "8" "377" "42.3" "6.83" "27.61" "8" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00432" "5229" "ENSG00000164219" "PGGT1B" "hsa:5229; P53609; Q5MJP9" "" "" "0" "0" "1.029" "0.989" "1.098" "1.048" "1.006" "0.928" "0.904" "0.869" "0.673" "836.9" "860.8" "827.7" "918.7" "876.7" "842.0" "776.6" "756.5" "726.9" "563.2" "" "" "" "" "" "" "" "" "" "" "443.1" "477.2" "474.0" "423.1" "474.3" "468.4" "457.1" "412.9" "407.8" "563.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7059158695698353069" "False" "High" "IsMasterProtein" "Q9H0U4" "Ras-related protein Rab-1B OS=Homo sapiens OX=9606 GN=RAB1B PE=1 SV=1" "0.000" "False" "26.347" "33" "8" "18" "3" "201" "22.2" "5.73" "47.73" "8" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00071" "81876" "ENSG00000174903" "RAB1B" "A8K7S1; hsa:81876; Q9H0U4" "" "COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization" "6" "4" "0.946" "0.965" "0.840" "0.929" "0.992" "0.928" "0.917" "0.962" "0.549" "3062.4" "2895.6" "2955.7" "2572.4" "2845.2" "3038.0" "2841.3" "2808.0" "2944.9" "1679.8" "" "" "" "" "" "" "" "" "" "" "1621.6" "1605.4" "1692.7" "1184.7" "1539.3" "1689.9" "1672.2" "1532.7" "1652.0" "1679.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4835883825689200365" "False" "High" "IsMasterProtein" "Q92979" "Ribosomal RNA small subunit methyltransferase NEP1 OS=Homo sapiens OX=9606 GN=EMG1 PE=1 SV=4" "0.000" "False" "26.335" "20" "5" "10" "5" "244" "26.7" "9.17" "26.59" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03587" "10436" "ENSG00000126749" "EMG1" "hsa:10436; O00675; O00726; Q92979" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.017" "1.009" "0.971" "1.050" "0.928" "1.133" "1.056" "1.042" "0.480" "544.7" "553.8" "549.5" "529.0" "572.2" "505.7" "616.9" "575.0" "567.6" "261.6" "" "" "" "" "" "" "" "" "" "" "288.4" "307.1" "314.7" "243.6" "309.6" "281.3" "363.1" "313.9" "318.4" "261.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3264120083815806641" "False" "High" "IsMasterProtein" "O14737" "Programmed cell death protein 5 OS=Homo sapiens OX=9606 GN=PDCD5 PE=1 SV=3" "0.000" "False" "26.298" "49" "6" "18" "6" "125" "14.3" "6.04" "38.69" "6" "other biological processes" "cytosol;nucleus" "enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf01984" "9141" "ENSG00000105185" "PDCD5" "B4DE64; hsa:9141; O14737; Q53YC9; Q6IB70" "" "" "0" "0" "0.981" "1.027" "1.057" "1.033" "0.949" "1.002" "1.046" "0.950" "0.647" "933.4" "915.7" "958.8" "986.7" "964.6" "886.1" "935.2" "976.4" "886.3" "604.0" "" "" "" "" "" "" "" "" "" "" "494.2" "507.7" "549.1" "454.4" "521.9" "492.9" "550.4" "533.0" "497.2" "604.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7556916282893625233" "False" "High" "IsMasterProtein" "O15347" "High mobility group protein B3 OS=Homo sapiens OX=9606 GN=HMGB3 PE=1 SV=4" "0.000" "False" "26.298" "25" "3" "5" "3" "200" "23.0" "8.37" "14.76" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00505, Pf09011" "3149" "ENSG00000029993" "HMGB3" "hsa:3149; O15347; O95556; Q6NS40" "" "" "0" "0" "0.975" "1.038" "1.232" "1.032" "0.849" "1.084" "1.061" "0.891" "0.525" "563.5" "549.6" "585.1" "694.3" "581.6" "478.5" "610.6" "597.8" "501.9" "295.8" "" "" "" "" "" "" "" "" "" "" "298.4" "304.7" "335.1" "319.7" "314.7" "266.2" "359.3" "326.3" "281.6" "295.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2971731893176673056" "False" "High" "IsMasterProtein" "O15305" "Phosphomannomutase 2 OS=Homo sapiens OX=9606 GN=PMM2 PE=1 SV=1" "0.000" "False" "26.265" "23" "5" "8" "5" "246" "28.1" "6.77" "25.62" "5" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03332" "5373" "ENSG00000140650" "PMM2" "A8K672; B7Z6R0; D3DUF3; hsa:5373; O15305" "Nephrotic syndrome; N-glycan biosynthesis; Primary ovarian insufficiency" "Defective PMM2 causes PMM2-CDG; Synthesis of GDP-mannose" "5" "0" "0.980" "1.016" "0.907" "0.996" "1.024" "0.979" "1.005" "1.000" "0.815" "804.5" "788.7" "817.4" "729.7" "801.0" "824.1" "787.7" "808.3" "804.7" "655.8" "" "" "" "" "" "" "" "" "" "" "426.0" "437.3" "468.1" "336.0" "433.4" "458.4" "463.6" "441.2" "451.4" "655.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6073254106150692843" "False" "High" "IsMasterProtein" "Q99575" "Ribonucleases P/MRP protein subunit POP1 OS=Homo sapiens OX=9606 GN=POP1 PE=1 SV=2" "0.000" "False" "26.256" "8" "7" "8" "7" "1024" "114.6" "9.22" "18.89" "7" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06978, Pf08170" "10940" "ENSG00000104356" "POP1" "A8K5W9; Q15037; Q99575" "" "tRNA processing in the nucleus" "1" "0" "0.952" "1.002" "0.929" "0.986" "0.949" "0.861" "0.907" "0.959" "0.775" "520.8" "495.7" "521.7" "483.8" "513.7" "494.4" "448.6" "472.1" "499.4" "403.5" "" "" "" "" "" "" "" "" "" "" "275.8" "274.8" "298.8" "222.8" "277.9" "275.0" "264.0" "257.7" "280.1" "403.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4751284344252295029" "False" "High" "IsMasterProtein" "P06748" "Nucleophosmin OS=Homo sapiens OX=9606 GN=NPM1 PE=1 SV=2" "0.000" "False" "26.234" "23" "8" "24" "8" "294" "32.6" "4.78" "66.36" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cell component" "enzyme regulator activity;translation activity;nucleic acid binding activity;other molecular function" "Pf03066, Pf16276" "4869" "ENSG00000181163" "NPM1" "A8K3N7; B5BU00; D3DQL6; hsa:4869; P06748; P08693; Q12826; Q13440; Q13441; Q14115; Q5EU94; Q5EU95; Q5EU96; Q5EU97; Q5EU98; Q5EU99; Q6V962; Q8WTW5; Q96AT6; Q96DC4; Q96EA5; Q9BYG9; Q9UDJ7" "" "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; PKR-mediated signaling; Nuclear import of Rev protein; Deposition of new CENPA-containing nucleosomes at the centromere; SUMOylation of transcription cofactors; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; Nuclear events stimulated by ALK signaling in cancer; SARS-CoV-1-host interactions" "10" "0" "1.123" "1.185" "1.043" "1.012" "0.939" "1.057" "1.175" "1.307" "1.459" "2494.1" "2800.6" "2956.1" "2601.9" "2524.4" "2343.0" "2636.1" "2931.4" "3260.5" "3638.2" "" "" "" "" "" "" "" "" "" "" "1320.6" "1552.7" "1692.9" "1198.3" "1365.8" "1303.3" "1551.4" "1600.1" "1829.1" "3638.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8471595991882746273" "False" "High" "IsMasterProtein" "P35612" "Beta-adducin OS=Homo sapiens OX=9606 GN=ADD2 PE=1 SV=3" "0.000" "False" "26.233" "10" "7" "11" "7" "726" "80.8" "5.92" "27.59" "7" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00596" "119" "ENSG00000075340" "ADD2" "A8K4P2; B4DM17; D6W5G7; D6W5G8; hsa:119; P35612; Q13482; Q16412; Q59G82; Q5U5P4; Q6P0P2; Q6PGQ4; Q7Z688; Q7Z689; Q7Z690; Q7Z691" "" "Miscellaneous transport and binding events" "1" "0" "1.028" "1.003" "1.092" "1.190" "1.148" "1.026" "1.119" "0.994" "0.738" "565.6" "581.2" "567.0" "617.9" "673.3" "649.5" "580.4" "632.9" "562.0" "417.5" "" "" "" "" "" "" "" "" "" "" "299.5" "322.2" "324.7" "284.5" "364.3" "361.3" "341.6" "345.5" "315.3" "417.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5820221568948669859" "False" "High" "IsMasterProtein" "P61081" "NEDD8-conjugating enzyme Ubc12 OS=Homo sapiens OX=9606 GN=UBE2M PE=1 SV=1" "0.000" "False" "26.202" "31" "6" "10" "6" "183" "20.9" "7.69" "28.17" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00179" "9040" "ENSG00000130725" "UBE2M" "hsa:9040; O76069; P61081; Q8VC50" "" "Antigen processing: Ubiquitination & Proteasome degradation; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Neddylation; TGF-beta receptor signaling activates SMADs" "5" "0" "1.046" "0.978" "1.095" "1.042" "1.041" "1.072" "0.970" "0.984" "1.376" "548.1" "573.2" "536.1" "600.4" "571.0" "570.4" "587.6" "531.5" "539.5" "753.9" "" "" "" "" "" "" "" "" "" "" "290.2" "317.8" "307.0" "276.5" "309.0" "317.3" "345.8" "290.1" "302.6" "753.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6664537344047956195" "False" "High" "IsMasterProtein" "Q08209" "Protein phosphatase 3 catalytic subunit alpha OS=Homo sapiens OX=9606 GN=PPP3CA PE=1 SV=1" "0.000" "False" "26.197" "13" "7" "13" "3" "521" "58.7" "5.86" "35.86" "7" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00149" "5530" "ENSG00000138814" "PPP3CA" "A1A441; A8K3B7; A8W6Z7; A8W6Z8; B5BUA2; hsa:5530; Q08209; Q8TAW9" "Physiological and pathological hypertrophy of the heart; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Spinal cord injury; Amyotrophic lateral sclerosis (ALS); T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; G protein signaling pathways; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Mitochondrial gene expression; Serotonin and anxiety-related events; Serotonin and anxiety; Wnt signaling; Vitamin D in inflammatory diseases; Fragile X syndrome; Alzheimer's disease; Th17 cell differentiation pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "FCERI mediated Ca+2 mobilization; CLEC7A (Dectin-1) induces NFAT activation; DARPP-32 events; Ca2+ pathway; Calcineurin activates NFAT" "26" "4" "0.905" "0.973" "0.911" "0.975" "0.944" "0.996" "0.933" "0.962" "0.691" "1200.3" "1086.0" "1168.2" "1093.7" "1169.8" "1132.6" "1195.2" "1119.9" "1155.2" "829.3" "" "" "" "" "" "" "" "" "" "" "635.6" "602.1" "669.0" "503.7" "632.9" "630.0" "703.4" "611.3" "648.1" "829.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "250780751349012114" "False" "High" "IsMasterProtein" "Cont_Q29443" "Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1" "0.000" "True" "26.143" "10" "7" "10" "7" "704" "77.7" "7.08" "25.08" "7" "stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle" "other molecular function" "Pf00405" "280705" "" "TF" "bta:280705; Q0IIK2; Q29443" "" "" "0" "0" "0.981" "1.059" "1.015" "1.264" "1.300" "1.143" "1.374" "1.477" "0.968" "1063.3" "1043.2" "1125.6" "1079.7" "1344.3" "1382.9" "1215.1" "1461.0" "1571.0" "1029.0" "" "" "" "" "" "" "" "" "" "" "563.0" "578.4" "644.6" "497.2" "727.3" "769.2" "715.1" "797.5" "881.3" "1029.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8178776459123092866" "False" "High" "IsMasterProtein" "P05387" "Large ribosomal subunit protein P2 OS=Homo sapiens OX=9606 GN=RPLP2 PE=1 SV=1" "0.000" "False" "26.138" "29" "3" "7" "3" "115" "11.7" "4.54" "24.51" "3" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf00428" "6181" "ENSG00000177600" "RPLP2" "hsa:6181; P05387; Q6FG96" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins; Opioid receptor pathways" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "16" "0" "1.215" "1.165" "1.353" "1.330" "1.163" "1.503" "1.713" "1.464" "0.611" "614.6" "746.9" "716.1" "831.4" "817.2" "714.9" "924.0" "1052.8" "899.6" "375.3" "" "" "" "" "" "" "" "" "" "" "325.4" "414.1" "410.1" "382.9" "442.2" "397.7" "543.8" "574.7" "504.7" "375.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7097595206598813277" "False" "High" "IsMasterProtein" "P09012" "U1 small nuclear ribonucleoprotein A OS=Homo sapiens OX=9606 GN=SNRPA PE=1 SV=3" "0.000" "False" "26.127" "25" "6" "19" "4" "282" "31.3" "9.83" "51.06" "6" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "6626" "ENSG00000077312" "SNRPA" "hsa:6626; P09012" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "1" "0.985" "0.941" "0.925" "0.961" "0.983" "0.997" "0.991" "0.969" "0.516" "1506.4" "1483.5" "1417.5" "1393.7" "1448.3" "1481.1" "1501.9" "1492.6" "1459.9" "777.9" "" "" "" "" "" "" "" "" "" "" "797.6" "822.5" "811.8" "641.8" "783.6" "823.9" "883.9" "814.7" "818.9" "777.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8898508644132712333" "False" "High" "IsMasterProtein" "Q01130" "Serine/arginine-rich splicing factor 2 OS=Homo sapiens OX=9606 GN=SRSF2 PE=1 SV=4" "0.000" "False" "26.088" "25" "6" "9" "6" "221" "25.5" "11.85" "24.35" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "6427" "ENSG00000161547" "SRSF2" "B3KWD5; B4DN89; H0YG49; hsa:6427; Q01130" "mRNA processing" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway" "7" "0" "1.035" "1.137" "1.072" "1.028" "0.958" "1.063" "1.017" "1.073" "0.754" "558.5" "578.3" "635.2" "598.8" "574.0" "535.1" "593.9" "568.2" "599.2" "421.0" "" "" "" "" "" "" "" "" "" "" "295.7" "320.6" "363.8" "275.8" "310.6" "297.6" "349.5" "310.1" "336.1" "421.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5859818642723021868" "False" "High" "IsMasterProtein" "Q96RS6" "NudC domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NUDCD1 PE=1 SV=2" "0.000" "False" "26.072" "10" "5" "6" "5" "583" "66.7" "5.11" "20.44" "5" "other biological processes" "cytosol;nucleus" "" "Pf04969" "84955" "ENSG00000120526" "NUDCD1" "B4DVX6; hsa:84955; Q4G130; Q8NDQ5; Q8NG18; Q96RS6; Q96SI4; Q9BVR5" "" "" "0" "0" "1.045" "1.018" "1.049" "1.070" "1.041" "0.997" "0.979" "0.942" "0.962" "369.1" "385.6" "375.7" "387.1" "394.9" "384.2" "368.1" "361.3" "347.8" "355.1" "" "" "" "" "" "" "" "" "" "" "195.4" "213.8" "215.2" "178.3" "213.7" "213.7" "216.6" "197.2" "195.1" "355.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-101820050033511890" "False" "High" "IsMasterProtein" "Q14966" "Zinc finger protein 638 OS=Homo sapiens OX=9606 GN=ZNF638 PE=1 SV=2" "0.000" "False" "26.071" "4" "8" "8" "8" "1978" "220.5" "6.38" "24.26" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf12171" "27332" "ENSG00000075292" "ZNF638" "A0A096LPH6; B5MDV1; B7ZLD1; hsa:27332; Q14966; Q53R34; Q5XJ05; Q68DP3; Q6P2H2; Q7Z3T7; Q8NF92; Q8TCA1; Q9H2G1; Q9NP37" "" "Transcriptional regulation of white adipocyte differentiation" "1" "0" "1.014" "0.937" "1.150" "1.203" "1.148" "1.912" "2.168" "2.132" "1.070" "487.9" "494.9" "457.1" "561.2" "586.8" "560.2" "933.0" "1057.5" "1040.1" "522.1" "" "" "" "" "" "" "" "" "" "" "258.3" "274.4" "261.8" "258.4" "317.5" "311.6" "549.1" "577.2" "583.5" "522.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2084755087725056383" "False" "High" "IsMasterProtein" "P05023" "Sodium/potassium-transporting ATPase subunit alpha-1 OS=Homo sapiens OX=9606 GN=ATP1A1 PE=1 SV=1" "0.000" "False" "26.053" "7" "8" "11" "8" "1023" "112.8" "5.49" "27.00" "8" "transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf00122, Pf00689, Pf00690, Pf13246" "476" "ENSG00000163399" "ATP1A1" "B2RBR6; B7Z2T5; B7Z3U6; F5H3A1; hsa:476; P05023; Q16689; Q6LDM4; Q9UCN1; Q9UJ20; Q9UJ21" "Pre-implantation embryo; Proximal tubule transport; Arsenic metabolism and reactive oxygen species generation" "Potential therapeutics for SARS; Ion homeostasis; Ion transport by P-type ATPases" "6" "0" "1.083" "1.094" "1.110" "1.073" "1.111" "1.096" "1.044" "0.943" "0.526" "522.4" "565.9" "571.5" "579.6" "560.5" "580.3" "572.4" "545.4" "492.8" "274.9" "" "" "" "" "" "" "" "" "" "" "276.6" "313.8" "327.3" "266.9" "303.3" "322.8" "336.9" "297.7" "276.5" "274.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4369435830510499583" "False" "High" "IsMasterProtein" "Q9GZP4" "PITH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PITHD1 PE=1 SV=1" "0.000" "False" "26.043" "30" "6" "10" "6" "211" "24.2" "5.74" "29.00" "6" "other biological processes" "other cell component" "" "Pf06201" "57095" "ENSG00000057757" "PITHD1" "B2R7J4; hsa:57095; Q5QPN6; Q5QPN7; Q9GZP4; Q9NRI8" "" "" "0" "0" "0.991" "0.979" "0.909" "0.907" "0.948" "1.007" "0.980" "0.934" "0.550" "1500.2" "1486.8" "1468.2" "1363.2" "1360.3" "1422.0" "1511.3" "1470.6" "1400.5" "824.5" "" "" "" "" "" "" "" "" "" "" "794.4" "824.3" "840.8" "627.8" "736.0" "791.0" "889.4" "802.7" "785.6" "824.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9085174644749999284" "False" "High" "IsMasterProtein" "Q4G0F5" "Vacuolar protein sorting-associated protein 26B OS=Homo sapiens OX=9606 GN=VPS26B PE=1 SV=2" "0.000" "False" "26.016" "21" "6" "9" "5" "336" "39.1" "7.36" "21.48" "6" "stress response;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf03643" "112936" "ENSG00000151502" "VPS26B" "hsa:112936; Q4G0F5; Q96A55" "" "" "0" "0" "1.087" "1.013" "1.004" "1.041" "1.057" "0.988" "1.007" "1.012" "1.205" "464.0" "504.5" "470.0" "466.1" "483.1" "490.4" "458.6" "467.4" "469.6" "559.1" "" "" "" "" "" "" "" "" "" "" "245.7" "279.7" "269.2" "214.6" "261.4" "272.8" "269.9" "255.1" "263.5" "559.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5955155913055998566" "False" "High" "IsMasterProtein" "P28062" "Proteasome subunit beta type-8 OS=Homo sapiens OX=9606 GN=PSMB8 PE=1 SV=3" "0.000" "False" "26.014" "23" "6" "10" "6" "276" "30.3" "7.43" "35.42" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227" "5696" "ENSG00000204264; ENSG00000206298; ENSG00000226201; ENSG00000230034; ENSG00000230669; ENSG00000231631; ENSG00000235715; ENSG00000236443" "PSMB8" "B0UZC0; hsa:5696; P28062; Q29824; Q5JNW6; Q5QNR8; Q96J48" "Proteasome degradation; Immune response to tuberculosis" "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Interferon alpha/beta signaling" "62" "0" "1.024" "1.030" "0.992" "1.073" "1.145" "1.030" "1.205" "1.025" "0.626" "663.8" "680.0" "683.8" "658.9" "712.1" "760.1" "683.4" "799.9" "680.4" "415.4" "" "" "" "" "" "" "" "" "" "" "351.5" "377.0" "391.6" "303.4" "385.3" "422.8" "402.2" "436.6" "381.7" "415.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6985960340352969870" "False" "High" "IsMasterProtein" "P62714" "Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PPP2CB PE=1 SV=1" "0.000" "False" "25.995" "23" "6" "14" "1" "309" "35.6" "5.43" "39.81" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00149" "5516" "ENSG00000104695" "PPP2CB" "D3DSV4; hsa:5516; P11082; P62714; Q6FHK5" "Serotonin transporter activity; Dopamine metabolism; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; Exercise-induced circadian regulation; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; Monoamine transport" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of TP53 Degradation; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RAF activation; Negative regulation of MAPK pathway; PKR-mediated signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Spry regulation of FGF signaling; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; DARPP-32 events; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "45" "4" "1.020" "1.026" "0.953" "1.063" "0.992" "1.073" "1.024" "0.930" "0.597" "1204.1" "1227.9" "1235.6" "1147.0" "1280.1" "1194.8" "1292.0" "1232.9" "1120.1" "718.5" "" "" "" "" "" "" "" "" "" "" "637.6" "680.8" "707.6" "528.2" "692.6" "664.6" "760.4" "673.0" "628.4" "718.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-719373628240286726" "False" "High" "IsMasterProtein" "O00231" "26S proteasome non-ATPase regulatory subunit 11 OS=Homo sapiens OX=9606 GN=PSMD11 PE=1 SV=3" "0.000" "False" "25.965" "15" "7" "9" "7" "422" "47.4" "6.48" "23.49" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01399, Pf18055, Pf18503" "5717" "ENSG00000108671" "PSMD11" "A8K3I7; E1P663; hsa:5717; O00231; O00495; Q53FT5" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling" "Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "1.044" "0.961" "0.974" "0.994" "1.039" "0.917" "0.939" "0.897" "0.700" "683.9" "713.8" "657.1" "666.2" "680.1" "710.5" "627.1" "642.5" "613.2" "479.0" "" "" "" "" "" "" "" "" "" "" "362.1" "395.7" "376.3" "306.8" "368.0" "395.2" "369.1" "350.7" "344.0" "479.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2238479499176412626" "False" "High" "IsMasterProtein" "O60828" "Polyglutamine-binding protein 1 OS=Homo sapiens OX=9606 GN=PQBP1 PE=1 SV=1" "0.000" "False" "25.958" "23" "5" "8" "5" "265" "30.5" "6.33" "25.06" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "10084" "ENSG00000102103; ENSG00000292208" "PQBP1" "C9JQA1; hsa:10084; O60828; Q4VY25; Q4VY26; Q4VY27; Q4VY29; Q4VY30; Q4VY34; Q4VY35; Q4VY36; Q4VY37; Q4VY38; Q9GZP2; Q9GZU4; Q9GZZ4" "" "mRNA Splicing - Major Pathway" "1" "0" "0.937" "1.041" "1.022" "1.010" "0.938" "0.993" "1.032" "0.965" "0.553" "533.0" "499.3" "554.9" "544.5" "538.1" "499.9" "529.2" "550.1" "514.1" "294.7" "" "" "" "" "" "" "" "" "" "" "282.2" "276.8" "317.8" "250.8" "291.1" "278.1" "311.5" "300.3" "288.4" "294.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "467994795181612484" "False" "High" "IsMasterProtein" "Q92793" "CREB-binding protein OS=Homo sapiens OX=9606 GN=CREBBP PE=1 SV=3" "0.000" "False" "25.924" "3" "8" "10" "5" "2442" "265.2" "8.53" "21.43" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00569, Pf02135, Pf02172, Pf06001, Pf08214, Pf09030" "1387" "ENSG00000005339" "CREBBP" "D3DUC9; O00147; Q16376; Q4LE28; Q92793" "Androgen receptor signaling pathway; Angiogenesis; TNF-alpha signaling pathway; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; IL6 signaling pathway; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; miRNA regulation of prostate cancer signaling pathways; Wnt signaling pathway and pluripotency; Clear cell renal cell carcinoma pathways; Ebola virus infection in host; Type 2 papillary renal cell carcinoma; Ciliary landscape; Hepatitis B infection; Male infertility; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; 15q13.3 copy number variation syndrome; Urotensin-II-mediated signaling pathway; Rubinstein-Taybi syndrome 1; 15q11q13 copy number variation; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways" "Heme signaling; NFE2L2 regulating anti-oxidant/detoxification enzymes; SUMOylation of transcription cofactors; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Zygotic genome activation (ZGA); PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; NPAS4 regulates expression of target genes; Formation of the beta-catenin:TCF transactivating complex; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); HATs acetylate histones; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; NFE2L2 regulating MDR associated enzymes; Nuclear events mediated by NFE2L2; NFE2L2 regulates pentose phosphate pathway genes; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; NFE2L2 regulating inflammation associated genes; NFE2L2 regulating tumorigenic genes; NFE2L2 regulating ER-stress associated genes; Regulation of NFE2L2 gene expression; RORA activates gene expression; Attenuation phase; CD209 (DC-SIGN) signaling; Activation of the TFAP2 (AP-2) family of transcription factors; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses; Regulation of gene expression by Hypoxia-inducible Factor; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production" "74" "0" "1.132" "1.067" "1.113" "1.078" "1.097" "1.090" "1.121" "1.070" "0.979" "397.1" "449.5" "423.6" "441.9" "428.0" "435.8" "432.8" "445.1" "424.8" "388.8" "" "" "" "" "" "" "" "" "" "" "210.3" "249.2" "242.6" "203.5" "231.5" "242.4" "254.7" "243.0" "238.3" "388.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5720484629679422275" "False" "High" "IsMasterProtein" "Q8WUA2" "Peptidyl-prolyl cis-trans isomerase-like 4 OS=Homo sapiens OX=9606 GN=PPIL4 PE=1 SV=1" "0.000" "False" "25.836" "14" "7" "10" "7" "492" "57.2" "5.92" "26.98" "7" "" "cytosol;nucleus" "other molecular function" "Pf00076, Pf00160" "85313" "ENSG00000131013" "PPIL4" "B2RD34; hsa:85313; Q7Z3Q5; Q8WUA2" "" "mRNA Splicing - Major Pathway" "1" "0" "0.949" "0.877" "1.068" "0.984" "1.038" "1.071" "0.992" "1.140" "2.361" "416.4" "395.3" "365.1" "444.7" "409.6" "432.0" "445.7" "413.1" "474.7" "983.0" "" "" "" "" "" "" "" "" "" "" "220.5" "219.1" "209.1" "204.8" "221.6" "240.3" "262.3" "225.5" "266.3" "983.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3797665255168145849" "False" "High" "IsMasterProtein" "P46087" "28S rRNA (cytosine(4447)-C(5))-methyltransferase OS=Homo sapiens OX=9606 GN=NOP2 PE=1 SV=2" "0.000" "False" "25.786" "10" "7" "11" "7" "812" "89.2" "9.23" "28.69" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01189, Pf08062, Pf17125" "4839" "ENSG00000111641" "NOP2" "A1A4Z3; B3KPD6; hsa:4839; P46087; Q05BA7; Q0P5S5; Q3KQS4; Q58F30" "Imatinib and chronic myeloid leukemia" "rRNA modification in the nucleus and cytosol; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation" "3" "0" "1.021" "1.063" "1.216" "1.160" "1.084" "1.575" "1.393" "1.490" "1.343" "346.2" "353.5" "367.9" "421.0" "401.5" "375.1" "545.4" "482.1" "515.8" "465.0" "" "" "" "" "" "" "" "" "" "" "183.3" "196.0" "210.7" "193.9" "217.2" "208.6" "321.0" "263.2" "289.3" "465.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4997024104720897707" "False" "High" "IsMasterProtein" "Q9BZK7" "F-box-like/WD repeat-containing protein TBL1XR1 OS=Homo sapiens OX=9606 GN=TBL1XR1 PE=1 SV=1" "0.000" "False" "25.707" "16" "6" "8" "4" "514" "55.6" "5.55" "25.26" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf08513" "79718" "ENSG00000177565" "TBL1XR1" "D3DNQ9; hsa:79718; Q14DC3; Q9BZK7; Q9H2I1; Q9H9A1" "Rett syndrome" "Heme signaling; Transcriptional activation of mitochondrial biogenesis; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; HCMV Early Events; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; BMAL1:CLOCK,NPAS2 activates circadian gene expression; HDACs deacetylate histones; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression" "20" "0" "0.939" "0.921" "0.976" "1.052" "1.040" "1.128" "1.049" "1.113" "0.823" "444.8" "417.8" "409.7" "434.1" "468.0" "462.6" "501.6" "466.6" "495.1" "366.1" "" "" "" "" "" "" "" "" "" "" "235.5" "231.6" "234.6" "199.9" "253.2" "257.3" "295.2" "254.7" "277.7" "366.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2273417600798469774" "False" "High" "IsMasterProtein" "Q10570" "Cleavage and polyadenylation specificity factor subunit 1 OS=Homo sapiens OX=9606 GN=CPSF1 PE=1 SV=2" "0.000" "False" "25.698" "5" "6" "7" "6" "1443" "160.8" "6.40" "21.61" "6" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03178, Pf10433" "29894" "ENSG00000071894; ENSG00000285049" "CPSF1" "hsa:29894; Q10570; Q96AF0" "mRNA processing" "Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "7" "0" "1.067" "0.959" "1.187" "1.081" "1.035" "1.166" "1.088" "1.114" "1.348" "522.4" "557.2" "500.8" "620.2" "564.6" "540.7" "609.4" "568.7" "581.9" "704.2" "" "" "" "" "" "" "" "" "" "" "276.6" "308.9" "286.8" "285.6" "305.5" "300.8" "358.7" "310.4" "326.4" "704.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5588804604694799714" "False" "High" "IsMasterProtein" "P36957" "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLST PE=1 SV=4" "0.000" "False" "25.688" "11" "5" "12" "5" "453" "48.7" "8.95" "36.86" "5" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00198, Pf00364" "1743" "ENSG00000119689" "DLST" "B7Z5W8; E7ESY5; hsa:1743; P36957; Q7LDY7; Q9BQ32" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Metabolic reprogramming in colon cancer; 7q11.23 copy number variation syndrome; 1p36 copy number variation syndrome; 10q11.21q11.23 copy number variation syndrome; TCA cycle (aka Krebs or citric acid cycle)" "Lysine catabolism; Glyoxylate metabolism and glycine degradation; Citric acid cycle (TCA cycle)" "10" "0" "0.953" "0.989" "0.865" "0.977" "0.927" "1.016" "0.976" "0.876" "0.477" "1938.0" "1846.3" "1917.3" "1676.4" "1893.5" "1795.8" "1969.0" "1891.6" "1696.7" "923.7" "" "" "" "" "" "" "" "" "" "" "1026.2" "1023.7" "1098.0" "772.0" "1024.5" "998.9" "1158.8" "1032.5" "951.8" "923.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8469309847663247920" "False" "High" "IsMasterProtein" "Q9UEY8" "Gamma-adducin OS=Homo sapiens OX=9606 GN=ADD3 PE=1 SV=1" "0.000" "False" "25.688" "11" "7" "11" "7" "706" "79.1" "6.32" "23.73" "7" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00596" "120" "ENSG00000148700" "ADD3" "D3DRA8; hsa:120; O43243; Q5VU09; Q92773; Q9UEY7; Q9UEY8" "" "Miscellaneous transport and binding events; RHOD GTPase cycle; RHOF GTPase cycle" "3" "0" "1.155" "1.097" "1.120" "1.270" "1.095" "1.182" "1.112" "1.089" "0.711" "344.0" "397.4" "377.5" "385.4" "436.9" "376.6" "406.5" "382.7" "374.7" "244.7" "" "" "" "" "" "" "" "" "" "" "182.2" "220.3" "216.2" "177.5" "236.4" "209.5" "239.3" "208.9" "210.2" "244.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2869717489525171844" "False" "High" "IsMasterProtein" "O60306" "RNA helicase aquarius OS=Homo sapiens OX=9606 GN=AQR PE=1 SV=4" "0.000" "False" "25.678" "5" "8" "10" "8" "1485" "171.2" "6.37" "20.82" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13086, Pf13087, Pf16399, Pf21143, Pf21144" "9716" "ENSG00000021776" "AQR" "A0JP17; A5YKK3; hsa:9716; O60306; Q2YDX9; Q6IRU8; Q6PIC8" "" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "5" "0" "1.049" "1.088" "1.033" "1.051" "1.065" "1.020" "0.996" "1.009" "1.233" "472.4" "495.5" "513.8" "488.0" "496.4" "503.3" "481.7" "470.5" "476.6" "582.2" "" "" "" "" "" "" "" "" "" "" "250.1" "274.7" "294.3" "224.7" "268.5" "280.0" "283.5" "256.8" "267.4" "582.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1824011876683044668" "False" "High" "IsMasterProtein" "Q9ULA0" "Aspartyl aminopeptidase OS=Homo sapiens OX=9606 GN=DNPEP PE=1 SV=2" "0.000" "False" "25.671" "16" "7" "9" "7" "485" "53.4" "7.58" "28.08" "7" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf02127" "23549" "ENSG00000123992" "DNPEP" "hsa:23549; Q9BW44; Q9NUV5; Q9NV55; Q9ULA0" "Ciliary landscape" "" "1" "0" "0.987" "0.956" "0.914" "0.959" "0.983" "1.022" "0.909" "0.993" "0.571" "1248.2" "1232.1" "1193.8" "1141.0" "1197.7" "1227.0" "1275.2" "1134.8" "1239.8" "712.9" "" "" "" "" "" "" "" "" "" "" "660.9" "683.1" "683.7" "525.5" "648.0" "682.5" "750.5" "619.5" "695.5" "712.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6534553132144552728" "False" "High" "IsMasterProtein" "Q09028" "Histone-binding protein RBBP4 OS=Homo sapiens OX=9606 GN=RBBP4 PE=1 SV=3" "0.000" "False" "25.652" "16" "5" "16" "3" "425" "47.6" "4.89" "41.23" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12265" "5928" "ENSG00000162521" "RBBP4" "B2R6G9; B4DRH0; D3DPQ3; hsa:5928; P31149; Q09028; Q53H02; Q96BV9" "Retinoblastoma gene in cancer; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; Effect of progerin on genes involved in progeria; Pleural mesothelioma; DYRK1A involvement regarding cell proliferation in brain development" "RNA Polymerase I Transcription Initiation; HCMV Early Events; Potential therapeutics for SARS; Deposition of new CENPA-containing nucleosomes at the centromere; Oxidative Stress Induced Senescence; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; Defective pyroptosis; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; PKMTs methylate histone lysines; G1/S-Specific Transcription; Regulation of TP53 Activity through Acetylation; Polo-like kinase mediated events; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "28" "0" "1.020" "0.994" "1.023" "1.062" "1.110" "1.279" "1.174" "1.143" "1.063" "119.3" "121.7" "118.6" "122.1" "126.7" "132.5" "152.6" "140.1" "136.4" "126.8" "" "" "" "" "" "" "" "" "" "" "63.2" "67.5" "67.9" "56.2" "68.6" "73.7" "89.8" "76.5" "76.5" "126.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1575369473679167499" "False" "High" "IsMasterProtein" "Q00059" "Transcription factor A, mitochondrial OS=Homo sapiens OX=9606 GN=TFAM PE=1 SV=1" "0.000" "False" "25.644" "32" "9" "12" "9" "246" "29.1" "9.72" "31.56" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf09011" "7019" "ENSG00000108064" "TFAM" "A8MRB2; A9QXC6; B5BU05; hsa:7019; Q00059; Q5U0C6" "Energy metabolism; NAD metabolism, sirtuins and aging; VEGFA-VEGFR2 signaling; Mitochondrial gene expression; Orexin receptor pathway; Sildenafil treatment" "Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein degradation" "9" "0" "0.963" "1.095" "0.928" "0.954" "1.014" "0.895" "1.078" "1.060" "0.605" "1046.7" "1007.5" "1146.3" "971.8" "998.4" "1061.2" "936.3" "1128.5" "1109.7" "633.6" "" "" "" "" "" "" "" "" "" "" "554.2" "558.6" "656.5" "447.6" "540.2" "590.3" "551.1" "616.0" "622.5" "633.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9177231757861531522" "False" "High" "IsMasterProtein" "P25685" "DnaJ homolog subfamily B member 1 OS=Homo sapiens OX=9606 GN=DNAJB1 PE=1 SV=4" "0.000" "False" "25.641" "17" "7" "9" "7" "340" "38.0" "8.63" "22.50" "7" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00226, Pf01556" "3337" "ENSG00000132002" "DNAJB1" "B4DX52; hsa:3337; P25685" "Nuclear receptors meta-pathway; NRF2 pathway" "MAPK6/MAPK4 signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Regulation of HSF1-mediated heat shock response; Attenuation phase" "7" "0" "1.023" "1.026" "1.186" "1.091" "1.033" "0.950" "0.926" "1.013" "2.415" "554.4" "567.0" "568.5" "657.7" "604.9" "572.9" "526.8" "513.6" "561.6" "1338.8" "" "" "" "" "" "" "" "" "" "" "293.5" "314.4" "325.6" "302.9" "327.3" "318.7" "310.1" "280.4" "315.0" "1338.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6056381579766233841" "False" "High" "IsMasterProtein" "Q9UNH7" "Sorting nexin-6 OS=Homo sapiens OX=9606 GN=SNX6 PE=1 SV=1" "0.000" "False" "25.567" "13" "6" "9" "5" "406" "46.6" "6.16" "28.00" "6" "transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00787, Pf09325" "58533" "ENSG00000129515" "SNX6" "C0H5W9; hsa:58533; Q9UNH7; Q9Y449" "" "" "0" "0" "0.984" "0.993" "0.949" "1.013" "1.057" "0.849" "0.873" "0.898" "1.621" "1087.1" "1069.9" "1079.1" "1032.0" "1101.3" "1149.3" "923.2" "949.0" "976.7" "1761.8" "" "" "" "" "" "" "" "" "" "" "575.6" "593.2" "618.0" "475.3" "595.8" "639.3" "543.3" "518.0" "547.9" "1761.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6670005547915153643" "False" "High" "IsMasterProtein" "O15400" "Syntaxin-7 OS=Homo sapiens OX=9606 GN=STX7 PE=1 SV=4" "0.000" "False" "25.534" "18" "4" "6" "4" "261" "29.8" "5.55" "21.76" "4" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05739, Pf14523" "8417" "ENSG00000079950" "STX7" "E1P579; hsa:8417; O15400; Q5SZW2; Q96ES9" "" "" "0" "0" "0.963" "1.010" "1.086" "0.988" "0.977" "1.221" "1.354" "1.131" "0.552" "554.3" "533.8" "560.0" "602.2" "547.9" "541.7" "676.5" "750.6" "626.9" "306.0" "" "" "" "" "" "" "" "" "" "" "293.5" "296.0" "320.7" "277.3" "296.4" "301.3" "398.2" "409.7" "351.7" "306.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8897927759308668761" "False" "High" "IsMasterProtein" "Q3KQV9" "UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 OS=Homo sapiens OX=9606 GN=UAP1L1 PE=1 SV=2" "0.000" "False" "25.510" "10" "5" "10" "3" "507" "57.0" "6.32" "28.23" "5" "other metabolic processes" "" "other molecular function" "Pf01704" "91373" "ENSG00000197355" "UAP1L1" "A2AMJ8; hsa:91373; Q3KQV9; Q5SPZ2; Q69YQ3; Q6ZR38" "" "" "0" "0" "1.149" "0.902" "1.117" "1.186" "1.190" "1.104" "0.934" "1.024" "0.786" "121.4" "139.5" "109.5" "135.7" "144.0" "144.4" "134.1" "113.4" "124.4" "95.4" "" "" "" "" "" "" "" "" "" "" "64.3" "77.4" "62.7" "62.5" "77.9" "80.3" "78.9" "61.9" "69.8" "95.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5949671281598126574" "False" "High" "IsMasterProtein" "Q13464" "Rho-associated protein kinase 1 OS=Homo sapiens OX=9606 GN=ROCK1 PE=1 SV=1" "0.000" "False" "25.493" "5" "8" "8" "7" "1354" "158.1" "5.90" "16.88" "8" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf08912" "6093" "ENSG00000067900" "ROCK1" "B0YJ91; hsa:6093; Q13464; Q2KHM4; Q59GZ4" "Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Focal adhesion; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; EGF/EGFR signaling pathway; Gastrin signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; GDNF signaling; G13 signaling pathway" "RND3 GTPase cycle; RHOBTB1 GTPase cycle; Neutrophil degranulation; VEGFA-VEGFR2 Pathway; G alpha (12/13) signalling events; EPHB-mediated forward signaling; Potential therapeutics for SARS; RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHOH GTPase cycle; Apoptotic cleavage of cellular proteins" "35" "1" "1.078" "1.014" "1.192" "1.123" "1.117" "1.208" "0.992" "1.233" "3.187" "389.9" "420.4" "395.2" "464.7" "438.1" "435.4" "471.2" "386.9" "480.6" "1242.8" "" "" "" "" "" "" "" "" "" "" "206.5" "233.1" "226.3" "214.0" "237.0" "242.2" "277.3" "211.2" "269.6" "1242.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8359022296663299879" "False" "High" "IsMasterProtein" "Q14258" "E3 ubiquitin/ISG15 ligase TRIM25 OS=Homo sapiens OX=9606 GN=TRIM25 PE=1 SV=2" "0.000" "False" "25.485" "7" "4" "5" "4" "630" "70.9" "8.09" "16.71" "4" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00622, Pf13445, Pf13765" "7706" "ENSG00000121060" "TRIM25" "hsa:7706; Q14258" "Novel intracellular components of RIG-I-like receptor pathway; Cytosolic DNA-sensing pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; 1p36 copy number variation syndrome" "SARS-CoV-1 activates/modulates innate immune responses; ISG15 antiviral mechanism; RSV-host interactions; PKR-mediated signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interferon gamma signaling; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses" "19" "0" "0.841" "0.874" "1.019" "0.933" "0.924" "1.016" "0.376" "1.071" "6.708" "207.3" "174.4" "181.3" "211.2" "193.3" "191.5" "210.6" "78.0" "222.0" "1390.6" "" "" "" "" "" "" "" "" "" "" "109.8" "96.7" "103.8" "97.3" "104.6" "106.5" "123.9" "42.6" "124.6" "1390.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7747633478491734615" "False" "High" "IsMasterProtein" "Q96BW5" "Phosphotriesterase-related protein OS=Homo sapiens OX=9606 GN=PTER PE=1 SV=1" "0.000" "False" "25.484" "17" "6" "8" "6" "349" "39.0" "6.52" "25.84" "6" "other metabolic processes;other biological processes" "" "other molecular function" "Pf02126" "9317" "ENSG00000165983" "PTER" "B0YJ77; B3KTF5; D3DRU0; hsa:9317; Q96BW5; Q9BY46" "" "" "0" "0" "0.934" "0.943" "0.955" "0.929" "0.955" "0.980" "0.940" "0.923" "0.635" "650.0" "606.9" "612.8" "621.1" "603.8" "621.1" "637.1" "611.2" "600.3" "412.8" "" "" "" "" "" "" "" "" "" "" "344.2" "336.5" "351.0" "286.0" "326.7" "345.5" "374.9" "333.6" "336.8" "412.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5135100836873347765" "False" "High" "IsMasterProtein" "Q5T200" "Zinc finger CCCH domain-containing protein 13 OS=Homo sapiens OX=9606 GN=ZC3H13 PE=1 SV=1" "0.000" "False" "25.481" "4" "8" "9" "8" "1668" "196.5" "9.42" "27.58" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00642" "23091" "ENSG00000123200" "ZC3H13" "A2A323; hsa:23091; O94936; Q5T1Z9; Q5T200; Q7Z7J3; Q8NDT6; Q9H0L6" "" "" "0" "0" "0.965" "1.027" "1.141" "1.076" "1.011" "1.346" "1.310" "1.343" "1.232" "883.3" "852.8" "907.3" "1008.3" "950.9" "893.4" "1188.5" "1156.9" "1186.3" "1088.4" "" "" "" "" "" "" "" "" "" "" "467.7" "472.8" "519.6" "464.3" "514.5" "497.0" "699.5" "631.5" "665.5" "1088.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6603036499622523787" "False" "High" "IsMasterProtein" "Q9Y2S7" "Polymerase delta-interacting protein 2 OS=Homo sapiens OX=9606 GN=POLDIP2 PE=1 SV=1" "0.000" "False" "25.468" "19" "6" "7" "6" "368" "42.0" "8.63" "17.55" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf04379, Pf08755" "26073" "ENSG00000004142" "POLDIP2" "B2R846; hsa:26073; Q96JE4; Q9Y2S7" "" "" "0" "0" "0.962" "0.894" "0.962" "1.028" "1.097" "0.994" "0.907" "0.843" "1.025" "424.8" "408.7" "379.6" "408.5" "436.8" "466.1" "422.3" "385.4" "358.2" "435.3" "" "" "" "" "" "" "" "" "" "" "224.9" "226.6" "217.4" "188.1" "236.3" "259.3" "248.6" "210.3" "200.9" "435.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4128416838288873001" "False" "High" "IsMasterProtein" "P11177" "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=PDHB PE=1 SV=3" "0.000" "False" "25.461" "12" "4" "7" "4" "359" "39.2" "6.65" "23.71" "4" "other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf02779, Pf02780" "5162" "ENSG00000168291" "PDHB" "B2R7L0; B4DDD7; hsa:5162; P11177; Q6FH45; Q9BQ27; Q9UFK3" "Hereditary leiomyomatosis and renal cell carcinoma pathway; Metabolic reprogramming in colon cancer; Orexin receptor pathway" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Mitochondrial protein degradation" "8" "0" "1.036" "1.059" "1.045" "1.108" "1.008" "0.871" "0.897" "0.728" "0.693" "612.6" "634.4" "648.6" "640.0" "678.9" "617.4" "533.5" "549.7" "446.1" "424.5" "" "" "" "" "" "" "" "" "" "" "324.4" "351.7" "371.5" "294.8" "367.3" "343.4" "314.0" "300.0" "250.3" "424.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "419048109363271085" "False" "High" "IsMasterProtein" "Q10713" "Mitochondrial-processing peptidase subunit alpha OS=Homo sapiens OX=9606 GN=PMPCA PE=1 SV=2" "0.000" "False" "25.447" "14" "8" "9" "8" "525" "58.2" "6.92" "21.52" "8" "protein metabolism;other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf00675, Pf05193" "23203" "ENSG00000165688" "PMPCA" "B4DKL3; E7ET61; hsa:23203; Q10713; Q16639; Q5SXM9; Q8N513" "" "Mitochondrial protein import; Mitochondrial protein degradation; Processing of SMDT1" "3" "0" "0.961" "0.955" "1.021" "0.926" "1.058" "0.977" "0.942" "0.987" "0.732" "446.4" "428.9" "426.2" "455.7" "413.6" "472.3" "436.0" "420.7" "440.6" "326.8" "" "" "" "" "" "" "" "" "" "" "236.4" "237.8" "244.1" "209.9" "223.8" "262.7" "256.6" "229.6" "247.2" "326.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4198310778640922638" "False" "High" "IsMasterProtein" "Q9Y3F4" "Serine-threonine kinase receptor-associated protein OS=Homo sapiens OX=9606 GN=STRAP PE=1 SV=1" "0.000" "False" "25.444" "19" "5" "13" "5" "350" "38.4" "5.12" "41.44" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00400" "11171" "ENSG00000023734" "STRAP" "B2R5S5; B4DNJ6; hsa:11171; Q5TZT4; Q9NTK0; Q9UQC8; Q9Y3F4" "TGF-beta signaling pathway; Epithelial to mesenchymal transition in colorectal cancer" "Downregulation of TGF-beta receptor signaling" "3" "0" "0.914" "0.925" "0.902" "1.005" "1.045" "1.068" "1.016" "1.030" "1.088" "1093.5" "999.2" "1011.2" "986.5" "1099.0" "1143.2" "1167.8" "1111.2" "1125.9" "1189.5" "" "" "" "" "" "" "" "" "" "" "579.0" "554.0" "579.1" "454.3" "594.6" "635.9" "687.3" "606.6" "631.6" "1189.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2616426161905977358" "False" "High" "IsMasterProtein" "Q9UG63" "ATP-binding cassette sub-family F member 2 OS=Homo sapiens OX=9606 GN=ABCF2 PE=1 SV=2" "0.000" "False" "25.387" "15" "10" "15" "10" "623" "71.2" "7.37" "33.63" "10" "" "" "other molecular function" "Pf00005, Pf12848" "10061; 114483834" "ENSG00000033050" "ABCF2" "hsa:10061; hsa:114483834; O60864; Q75MJ0; Q75MJ1; Q96TE8; Q9UG63" "VEGFA-VEGFR2 signaling" "NFE2L2 regulating MDR associated enzymes" "2" "0" "1.030" "1.014" "1.122" "1.208" "1.176" "1.066" "1.027" "1.100" "0.773" "1454.3" "1498.6" "1474.7" "1631.5" "1756.2" "1710.5" "1550.0" "1493.9" "1599.2" "1124.0" "" "" "" "" "" "" "" "" "" "" "770.1" "830.8" "844.6" "751.4" "950.2" "951.5" "912.3" "815.4" "897.1" "1124.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1017068245716453317" "False" "High" "IsMasterProtein" "O95782" "AP-2 complex subunit alpha-1 OS=Homo sapiens OX=9606 GN=AP2A1 PE=1 SV=3" "0.000" "False" "25.335" "7" "8" "12" "3" "977" "107.5" "7.03" "30.32" "8" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01602, Pf02296, Pf02883" "160" "ENSG00000196961" "AP2A1" "hsa:160; O95782; Q96CI7; Q96PP6; Q96PP7; Q9H070" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; mBDNF and proBDNF regulation of GABA neurotransmission; Cell lineage map for neuronal differentiation" "Potential therapeutics for SARS; Recycling pathway of L1; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Trafficking of GluR2-containing AMPA receptors; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "21" "4" "1.000" "0.940" "1.097" "1.034" "1.083" "1.100" "1.084" "1.118" "0.927" "1294.2" "1294.2" "1215.9" "1419.8" "1338.2" "1401.0" "1423.1" "1403.2" "1446.3" "1199.5" "" "" "" "" "" "" "" "" "" "" "685.3" "717.5" "696.4" "653.9" "724.0" "779.3" "837.5" "765.9" "811.3" "1199.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4889317708786741676" "False" "High" "IsMasterProtein" "Q96AT1" "Uncharacterized protein KIAA1143 OS=Homo sapiens OX=9606 GN=KIAA1143 PE=1 SV=2" "0.000" "False" "25.322" "27" "4" "12" "4" "154" "17.5" "6.11" "27.13" "4" "" "" "" "Pf15377" "57456" "ENSG00000163807; ENSG00000281665" "KIAA1143" "A8K0I4; hsa:57456; Q96AT1; Q96HJ8; Q9ULS7" "" "" "0" "0" "0.979" "1.067" "1.059" "1.018" "0.942" "0.998" "0.988" "0.834" "0.518" "442.9" "433.7" "472.7" "468.9" "450.8" "417.4" "442.0" "437.7" "369.5" "229.5" "" "" "" "" "" "" "" "" "" "" "234.5" "240.5" "270.7" "216.0" "243.9" "232.2" "260.1" "238.9" "207.3" "229.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "779852501093026521" "False" "High" "IsMasterProtein" "P15153" "Ras-related C3 botulinum toxin substrate 2 OS=Homo sapiens OX=9606 GN=RAC2 PE=1 SV=1" "0.000" "False" "25.235" "27" "5" "10" "4" "192" "21.4" "7.61" "31.72" "5" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00071" "5880" "ENSG00000128340" "RAC2" "hsa:5880; P15153; Q9UDJ4" "Integrin-mediated cell adhesion; RalA downstream regulated genes; B cell receptor signaling pathway; Focal adhesion; MAPK signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; Macrophage markers; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Insulin signaling; Regulation of actin cytoskeleton; Pathways in cancer; DNA damage response (only ATM dependent)" "RAC2 GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; PCP/CE pathway; ROS and RNS production in phagocytes; RHO GTPases Activate NADPH Oxidases" "24" "1" "1.016" "0.931" "0.996" "1.056" "0.968" "0.981" "0.889" "0.865" "0.744" "496.6" "504.5" "462.4" "494.5" "524.5" "480.7" "487.0" "441.5" "429.7" "369.6" "" "" "" "" "" "" "" "" "" "" "262.9" "279.7" "264.8" "227.7" "283.8" "267.4" "286.6" "241.0" "241.0" "369.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1566941551472469516" "False" "High" "IsMasterProtein" "O60508" "Pre-mRNA-processing factor 17 OS=Homo sapiens OX=9606 GN=CDC40 PE=1 SV=1" "0.000" "False" "25.224" "11" "7" "9" "7" "579" "65.5" "7.06" "25.12" "7" "RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "nucleic acid binding activity" "Pf00400" "51362" "ENSG00000168438" "CDC40" "B2RBC5; hsa:51362; O60508; O75471; Q5SRN0; Q9UPG1" "mRNA processing" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway" "5" "0" "1.030" "0.940" "0.938" "0.987" "0.999" "1.156" "1.214" "1.003" "0.428" "384.9" "396.6" "361.6" "361.1" "379.8" "384.7" "444.8" "467.3" "385.9" "164.7" "" "" "" "" "" "" "" "" "" "" "203.8" "219.9" "207.1" "166.3" "205.5" "214.0" "261.8" "255.1" "216.5" "164.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-216911938682189755" "False" "High" "IsMasterProtein" "Q27J81" "Inverted formin-2 OS=Homo sapiens OX=9606 GN=INF2 PE=1 SV=2" "0.000" "False" "25.216" "6" "6" "7" "6" "1249" "135.5" "5.38" "13.33" "6" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf02181, Pf02205, Pf06367, Pf06371" "64423" "ENSG00000203485" "INF2" "hsa:64423; Q27J81; Q27J83; Q69YL8; Q6P1X7; Q6PK22; Q86TR7; Q9BRM1; Q9H6N1" "Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome" "" "2" "0" "0.841" "1.031" "1.206" "1.084" "1.099" "1.286" "1.304" "1.200" "1.225" "244.5" "205.6" "252.1" "294.8" "265.2" "268.8" "314.4" "318.9" "293.4" "299.6" "" "" "" "" "" "" "" "" "" "" "129.5" "114.0" "144.4" "135.8" "143.5" "149.5" "185.0" "174.1" "164.6" "299.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6104369569183716546" "False" "High" "IsMasterProtein" "P36915" "Guanine nucleotide-binding protein-like 1 OS=Homo sapiens OX=9606 GN=GNL1 PE=1 SV=2" "0.000" "False" "25.170" "9" "5" "8" "5" "607" "68.6" "5.80" "24.71" "5" "stress response;signal transduction;other biological processes" "non-structural extracellular" "other molecular function" "Pf01926" "2794" "ENSG00000204590; ENSG00000206492; ENSG00000226882; ENSG00000228581; ENSG00000229470; ENSG00000232143; ENSG00000235986" "GNL1" "B0S838; hsa:2794; P36915; Q96CT5" "" "" "0" "0" "0.948" "0.989" "0.960" "0.980" "1.001" "0.735" "0.748" "0.788" "1.322" "766.1" "726.6" "757.5" "735.1" "751.0" "766.5" "563.2" "573.2" "603.4" "1012.8" "" "" "" "" "" "" "" "" "" "" "405.6" "402.8" "433.8" "338.5" "406.3" "426.3" "331.4" "312.9" "338.5" "1012.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5778599060552415361" "False" "High" "IsMasterProtein" "P52272" "Heterogeneous nuclear ribonucleoprotein M OS=Homo sapiens OX=9606 GN=HNRNPM PE=1 SV=3" "0.000" "False" "25.122" "10" "8" "14" "8" "730" "77.5" "8.70" "17.43" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf11532" "4670" "ENSG00000099783" "HNRNPM" "hsa:4670; P52272; Q15584; Q8WZ44; Q96H56; Q9BWL9; Q9Y492" "mRNA processing" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "4" "0" "1.104" "1.037" "1.060" "1.085" "0.980" "1.048" "0.089" "0.957" "14.337" "275.0" "303.5" "285.1" "291.5" "298.5" "269.6" "288.2" "24.5" "263.2" "3942.9" "" "" "" "" "" "" "" "" "" "" "145.6" "168.3" "163.3" "134.2" "161.5" "150.0" "169.6" "13.4" "147.7" "3942.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1299453744240154091" "False" "High" "IsMasterProtein" "Q96EB1" "Elongator complex protein 4 OS=Homo sapiens OX=9606 GN=ELP4 PE=1 SV=2" "0.000" "False" "25.115" "18" "8" "8" "8" "424" "46.6" "8.51" "21.12" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity" "Pf05625" "26610" "ENSG00000109911" "ELP4" "B4E3W0; E7EPZ6; hsa:26610; Q96EB1; Q9H4E8; Q9NX11" "Mesodermal commitment pathway" "HATs acetylate histones" "2" "0" "1.004" "0.988" "1.017" "1.040" "0.970" "0.943" "1.030" "0.966" "0.754" "1966.5" "1973.6" "1942.1" "1999.6" "2045.5" "1907.2" "1854.1" "2025.0" "1900.4" "1483.5" "" "" "" "" "" "" "" "" "" "" "1041.2" "1094.2" "1112.2" "920.9" "1106.7" "1060.9" "1091.2" "1105.4" "1066.1" "1483.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1710957495581241362" "False" "High" "IsMasterProtein" "Q15276" "Rab GTPase-binding effector protein 1 OS=Homo sapiens OX=9606 GN=RABEP1 PE=1 SV=2" "0.000" "False" "25.111" "9" "9" "10" "9" "862" "99.2" "5.01" "25.31" "9" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf03528, Pf09311" "9135" "ENSG00000029725" "RABEP1" "B2RAG7; hsa:9135; O95369; Q15276; Q8IVX3" "GDNF signaling" "TBC/RABGAPs" "2" "0" "1.026" "1.012" "1.093" "1.090" "1.057" "1.139" "1.093" "1.172" "1.637" "335.1" "343.9" "339.0" "366.3" "365.3" "354.1" "381.6" "366.1" "392.7" "548.3" "" "" "" "" "" "" "" "" "" "" "177.4" "190.6" "194.1" "168.7" "197.6" "196.9" "224.6" "199.9" "220.3" "548.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4495210949063335174" "False" "High" "IsMasterProtein" "Q7L576" "Cytoplasmic FMR1-interacting protein 1 OS=Homo sapiens OX=9606 GN=CYFIP1 PE=1 SV=1" "0.000" "False" "25.106" "5" "7" "7" "2" "1253" "145.1" "6.90" "20.11" "7" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf05994, Pf07159" "23191" "ENSG00000273749; ENSG00000288461" "CYFIP1" "A8K6D9; hsa:23191; Q14467; Q5IED0; Q6ZSX1; Q7L576; Q9BSD9; Q9BVC7" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Prader-Willi and Angelman syndrome; Fragile X syndrome; Disruption of postsynaptic signaling by CNV; 15q11.2 copy number variation syndrome; G13 signaling pathway" "Neutrophil degranulation; VEGFA-VEGFR2 Pathway; RAC1 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHOG GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4848628119440074227" "False" "High" "IsMasterProtein" "P30038" "Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH4A1 PE=1 SV=3" "0.000" "False" "25.104" "12" "7" "8" "7" "563" "61.7" "8.07" "20.42" "7" "other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00171" "8659" "ENSG00000159423" "ALDH4A1" "A8K1Q7; B4DGE4; D2D4A3; hsa:8659; P30038; Q16882; Q53HU4; Q5JNV6; Q8IZ38; Q96IF0; Q9UDI6" "22q11.2 copy number variation syndrome; p53 transcriptional gene network" "Glyoxylate metabolism and glycine degradation; Proline catabolism" "4" "0" "0.979" "0.940" "1.023" "1.081" "1.092" "0.822" "0.807" "0.828" "1.130" "614.5" "601.7" "577.9" "628.9" "664.4" "671.2" "504.9" "496.1" "508.7" "694.5" "" "" "" "" "" "" "" "" "" "" "325.4" "333.6" "331.0" "289.6" "359.4" "373.4" "297.2" "270.8" "285.4" "694.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8293533738236197165" "False" "High" "IsMasterProtein" "O75347" "Tubulin-specific chaperone A OS=Homo sapiens OX=9606 GN=TBCA PE=1 SV=3" "0.000" "False" "25.092" "40" "5" "12" "5" "108" "12.8" "5.29" "33.06" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02970" "6902" "ENSG00000171530" "TBCA" "B4DT30; hsa:6902; O75347" "VEGFA-VEGFR2 signaling" "Post-chaperonin tubulin folding pathway" "2" "0" "0.993" "1.039" "1.036" "0.966" "0.959" "0.969" "0.990" "0.844" "0.466" "1765.4" "1753.0" "1834.9" "1829.4" "1705.0" "1692.6" "1711.5" "1747.9" "1490.2" "822.9" "" "" "" "" "" "" "" "" "" "" "934.8" "971.9" "1050.9" "842.5" "922.5" "941.5" "1007.3" "954.1" "836.0" "822.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-728784246141405942" "False" "High" "IsMasterProtein" "P09543" "2',3'-cyclic-nucleotide 3'-phosphodiesterase OS=Homo sapiens OX=9606 GN=CNP PE=1 SV=2" "0.000" "False" "25.063" "14" "6" "7" "6" "421" "47.5" "9.07" "21.50" "6" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytoskeleton;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf05881, Pf13671" "1267" "ENSG00000173786" "CNP" "hsa:1267; P09543" "Glial cell differentiation; MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Cell lineage map for neuronal differentiation" "" "5" "0" "1.023" "0.992" "1.012" "1.045" "1.025" "0.875" "0.863" "0.979" "1.348" "653.9" "668.8" "648.5" "661.6" "683.3" "670.0" "572.1" "564.0" "639.8" "881.7" "" "" "" "" "" "" "" "" "" "" "346.2" "370.8" "371.4" "304.7" "369.7" "372.7" "336.7" "307.9" "358.9" "881.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5604627173476332081" "False" "High" "IsMasterProtein" "O75534" "Cold shock domain-containing protein E1 OS=Homo sapiens OX=9606 GN=CSDE1 PE=1 SV=2" "0.000" "False" "25.042" "11" "9" "11" "9" "798" "88.8" "6.25" "25.67" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "nucleic acid binding activity" "Pf00313, Pf12901" "7812" "ENSG00000009307" "CSDE1" "A8K281; E9PGZ0; G5E9Q2; hsa:7812; O75534; O94961; Q5TF04; Q5TF05; Q68DF1; Q68DI9; Q9Y2S4" "" "" "0" "0" "1.112" "1.009" "1.083" "1.063" "1.156" "1.158" "0.503" "0.946" "8.332" "271.3" "301.6" "273.7" "293.7" "288.5" "313.5" "314.1" "136.4" "256.8" "2260.5" "" "" "" "" "" "" "" "" "" "" "143.7" "167.2" "156.8" "135.3" "156.1" "174.4" "184.9" "74.5" "144.0" "2260.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8124726233717471609" "False" "High" "IsMasterProtein" "P50750" "Cyclin-dependent kinase 9 OS=Homo sapiens OX=9606 GN=CDK9 PE=1 SV=3" "0.000" "False" "24.985" "18" "6" "10" "5" "372" "42.8" "8.79" "21.02" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069" "1025" "ENSG00000136807" "CDK9" "hsa:1025; P50750; Q5JU24; Q5JU25; Q5U006; Q96TF1" "MicroRNAs in cardiomyocyte hypertrophy; IL-9 signaling pathway; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility" "Estrogen-dependent gene expression; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Interactions of Tat with host cellular proteins" "20" "0" "0.915" "1.070" "1.292" "0.958" "0.967" "1.094" "1.078" "1.051" "1.097" "356.1" "325.8" "381.0" "460.0" "341.1" "344.5" "389.7" "383.9" "374.2" "390.5" "" "" "" "" "" "" "" "" "" "" "188.6" "180.6" "218.2" "211.8" "184.5" "191.6" "229.3" "209.5" "209.9" "390.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6634363274650926044" "False" "High" "IsMasterProtein" "Q14839" "Chromodomain-helicase-DNA-binding protein 4 OS=Homo sapiens OX=9606 GN=CHD4 PE=1 SV=2" "0.000" "False" "24.981" "4" "8" "13" "8" "1912" "217.9" "5.86" "32.35" "8" "cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf00628, Pf06461, Pf06465, Pf08073, Pf08074" "1108" "ENSG00000111642" "CHD4" "Q14839; Q8IXZ5" "Rett syndrome; Effect of progerin on genes involved in progeria" "RNA Polymerase I Transcription Initiation; Potential therapeutics for SARS; HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of PTEN gene transcription; Regulation of TP53 Activity through Acetylation; NGF-stimulated transcription" "9" "0" "0.964" "0.983" "1.203" "1.120" "1.128" "1.515" "1.033" "1.525" "6.230" "421.1" "405.7" "413.9" "506.6" "471.6" "475.0" "638.0" "434.9" "642.1" "2623.1" "" "" "" "" "" "" "" "" "" "" "223.0" "225.0" "237.0" "233.3" "255.1" "264.2" "375.5" "237.4" "360.2" "2623.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5432753500567823498" "False" "High" "IsMasterProtein" "O75390" "Citrate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=CS PE=1 SV=2" "0.000" "False" "24.949" "13" "6" "12" "6" "466" "51.7" "8.32" "33.65" "6" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00285" "1431" "ENSG00000062485" "CS" "hsa:1431; O75390; Q71UT9; Q7KZH0; Q96FZ8; Q9BWN8" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)" "Mitochondrial protein import; Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "7" "0" "0.993" "0.992" "0.947" "0.986" "1.005" "0.943" "0.964" "0.921" "0.701" "1209.5" "1201.3" "1200.2" "1145.2" "1192.4" "1215.5" "1140.2" "1165.7" "1113.8" "848.3" "" "" "" "" "" "" "" "" "" "" "640.4" "666.0" "687.4" "527.4" "645.1" "676.1" "671.0" "636.3" "624.8" "848.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2921825731244054349" "False" "High" "IsMasterProtein" "Q99714" "3-hydroxyacyl-CoA dehydrogenase type-2 OS=Homo sapiens OX=9606 GN=HSD17B10 PE=1 SV=3" "0.000" "False" "24.921" "22" "5" "13" "5" "261" "26.9" "7.78" "43.57" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00106" "3028" "ENSG00000072506" "HSD17B10" "hsa:3028; Q5H927; Q6IBS9; Q8TCV9; Q96HD5; Q99714" "Alzheimer's disease and miRNA effects; Valproic acid pathway; Alzheimer's disease" "Mitochondrial protein degradation; Branched-chain amino acid catabolism; tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion" "8" "0" "0.915" "0.858" "0.913" "0.984" "0.978" "0.844" "0.919" "0.898" "0.628" "240.3" "219.9" "206.3" "219.3" "236.5" "235.0" "202.7" "220.8" "215.7" "150.9" "" "" "" "" "" "" "" "" "" "" "127.2" "121.9" "118.1" "101.0" "127.9" "130.7" "119.3" "120.5" "121.0" "150.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4758086446517534587" "False" "High" "IsMasterProtein" "P62316" "Small nuclear ribonucleoprotein Sm D2 OS=Homo sapiens OX=9606 GN=SNRPD2 PE=1 SV=1" "0.000" "False" "24.915" "37" "5" "17" "5" "118" "13.5" "9.91" "43.45" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf01423" "6633" "ENSG00000125743" "SNRPD2" "A8K797; hsa:6633; J3KPM5; P43330; P62316" "mRNA processing" "mRNA Splicing - Major Pathway; snRNP Assembly; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway" "5" "0" "1.001" "1.047" "1.016" "1.020" "1.001" "1.098" "1.154" "1.097" "0.553" "1219.9" "1220.9" "1277.2" "1239.9" "1244.0" "1220.9" "1340.0" "1408.2" "1338.6" "674.8" "" "" "" "" "" "" "" "" "" "" "645.9" "676.9" "731.4" "571.0" "673.0" "679.1" "788.6" "768.7" "750.9" "674.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6529775950404904251" "False" "High" "IsMasterProtein" "Q9UBC2" "Epidermal growth factor receptor substrate 15-like 1 OS=Homo sapiens OX=9606 GN=EPS15L1 PE=1 SV=1" "0.000" "False" "24.900" "8" "7" "7" "7" "864" "94.2" "5.11" "19.20" "7" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12763" "58513" "ENSG00000127527" "EPS15L1" "A2RRF3; A5PL29; B4DKA3; hsa:58513; Q9UBC2" "EGF/EGFR signaling pathway" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation" "4" "0" "1.037" "0.955" "1.098" "1.001" "1.090" "1.284" "1.179" "1.294" "1.967" "642.4" "666.1" "613.4" "705.4" "643.1" "700.0" "825.1" "757.5" "831.0" "1263.6" "" "" "" "" "" "" "" "" "" "" "340.2" "369.3" "351.3" "324.9" "347.9" "389.4" "485.6" "413.5" "466.2" "1263.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1037069693652576559" "False" "High" "IsMasterProtein" "P31943" "Heterogeneous nuclear ribonucleoprotein H OS=Homo sapiens OX=9606 GN=HNRNPH1 PE=1 SV=4" "0.000" "False" "24.829" "10" "4" "8" "3" "449" "49.2" "6.30" "24.02" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08080" "3187" "ENSG00000169045; ENSG00000284254" "HNRNPH1" "B3KW86; D3DWQ2; P31943; Q6IBM4" "MECP2 and associated Rett syndrome; mRNA processing; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "6" "0" "0.866" "0.835" "1.069" "0.848" "0.981" "1.010" "0.615" "0.890" "5.627" "290.4" "251.5" "242.5" "310.5" "246.2" "284.8" "293.3" "178.5" "258.4" "1633.9" "" "" "" "" "" "" "" "" "" "" "153.7" "139.4" "138.9" "143.0" "133.2" "158.4" "172.6" "97.4" "144.9" "1633.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7322766248926009386" "False" "High" "IsMasterProtein" "Q13564" "NEDD8-activating enzyme E1 regulatory subunit OS=Homo sapiens OX=9606 GN=NAE1 PE=1 SV=1" "0.000" "False" "24.822" "13" "5" "6" "5" "534" "60.2" "5.40" "15.76" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00899" "8883" "ENSG00000159593" "NAE1" "A6NCK0; A6NFN4; A8MU28; B2R700; B3KUP9; hsa:8883; Q13564" "Alzheimer's disease and miRNA effects; Hijack of ubiquitination by SARS-CoV-2; Alzheimer's disease" "Neddylation" "4" "0" "0.993" "0.947" "0.895" "0.963" "0.929" "0.882" "0.936" "0.898" "1.217" "623.8" "619.4" "590.9" "558.1" "600.9" "579.4" "550.3" "584.0" "560.0" "758.9" "" "" "" "" "" "" "" "" "" "" "330.3" "343.4" "338.4" "257.0" "325.1" "322.3" "323.8" "318.8" "314.1" "758.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1351774447437735542" "False" "High" "IsMasterProtein" "Q9NQW7" "Xaa-Pro aminopeptidase 1 OS=Homo sapiens OX=9606 GN=XPNPEP1 PE=1 SV=3" "0.000" "False" "24.764" "12" "9" "16" "8" "623" "69.9" "5.67" "40.27" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00557, Pf01321, Pf16188, Pf16189" "7511" "ENSG00000108039" "XPNPEP1" "A8K071; G5E9Y2; G8JLB2; hsa:7511; O15250; Q53EX6; Q8N3Q0; Q96D23; Q9NQW7" "" "" "0" "1" "0.991" "1.024" "1.000" "1.045" "1.038" "1.004" "0.950" "0.952" "1.162" "1280.9" "1269.3" "1311.1" "1281.0" "1337.9" "1330.0" "1286.5" "1216.3" "1219.1" "1488.6" "" "" "" "" "" "" "" "" "" "" "678.2" "703.7" "750.9" "589.9" "723.9" "739.8" "757.2" "663.9" "683.9" "1488.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2914348929085593862" "False" "High" "IsMasterProtein" "Q96F07" "Cytoplasmic FMR1-interacting protein 2 OS=Homo sapiens OX=9606 GN=CYFIP2 PE=1 SV=2" "0.000" "False" "24.761" "6" "8" "8" "3" "1278" "148.3" "7.31" "22.29" "8" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05994, Pf07159" "26999" "ENSG00000055163" "CYFIP2" "A6NLT2; D3DQJ3; hsa:26999; Q53EN5; Q96F07; Q9NTK4; Q9ULQ2; Q9UN29" "Fragile X syndrome; Regulation of actin cytoskeleton" "RAC1 GTPase cycle; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs" "7" "2" "0.939" "0.954" "0.827" "0.901" "1.005" "0.820" "0.869" "0.854" "1.146" "504.0" "473.0" "480.9" "416.7" "454.2" "506.4" "413.3" "437.9" "430.6" "577.4" "" "" "" "" "" "" "" "" "" "" "266.8" "262.2" "275.4" "191.9" "245.7" "281.7" "243.3" "239.0" "241.5" "577.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5753903603639706733" "False" "High" "IsMasterProtein" "Q15021" "Condensin complex subunit 1 OS=Homo sapiens OX=9606 GN=NCAPD2 PE=1 SV=3" "0.000" "False" "24.759" "5" "8" "9" "8" "1401" "157.1" "6.61" "18.96" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12717, Pf12922" "9918" "ENSG00000010292" "NCAPD2" "D3DUR4; hsa:9918; Q15021; Q8N6U3" "" "Condensation of Prometaphase Chromosomes" "1" "0" "1.246" "1.040" "1.217" "1.151" "1.174" "1.090" "0.449" "1.065" "8.498" "306.1" "381.5" "318.2" "372.4" "352.2" "359.2" "333.6" "137.4" "325.9" "2600.9" "" "" "" "" "" "" "" "" "" "" "162.1" "211.5" "182.2" "171.5" "190.6" "199.8" "196.3" "75.0" "182.8" "2600.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5765443992663171126" "False" "High" "IsMasterProtein" "Q86UE8" "Serine/threonine-protein kinase tousled-like 2 OS=Homo sapiens OX=9606 GN=TLK2 PE=1 SV=2" "0.000" "False" "24.750" "8" "6" "8" "3" "772" "87.6" "8.41" "24.68" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "11011" "ENSG00000146872" "TLK2" "D3DU07; hsa:11011; Q86UE8; Q9UKI7; Q9Y4F7" "miRNA regulation of DNA damage response; DNA damage response" "" "2" "2" "1.043" "0.979" "1.077" "1.029" "1.048" "0.963" "0.930" "0.975" "0.898" "674.8" "704.1" "660.4" "726.8" "694.7" "707.5" "649.7" "627.4" "658.0" "606.2" "" "" "" "" "" "" "" "" "" "" "357.3" "390.4" "378.2" "334.7" "375.8" "393.5" "382.4" "342.4" "369.1" "606.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3245672403803654152" "False" "High" "IsMasterProtein" "P62263" "Small ribosomal subunit protein uS11 OS=Homo sapiens OX=9606 GN=RPS14 PE=1 SV=3" "0.000" "False" "24.728" "30" "4" "6" "4" "151" "16.3" "10.05" "17.87" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00411" "6208" "ENSG00000164587" "RPS14" "B2R5G5; D3DQG5; hsa:6208; P06366; P62263; Q5BJI0" "Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; rRNA modification in the nucleus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "20" "0" "1.185" "1.181" "1.400" "1.188" "1.301" "1.436" "1.285" "1.446" "1.913" "460.4" "545.5" "543.7" "644.6" "546.9" "598.8" "661.0" "591.4" "665.9" "880.6" "" "" "" "" "" "" "" "" "" "" "243.8" "302.5" "311.4" "296.9" "295.9" "333.1" "389.0" "322.8" "373.5" "880.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6634155616669097337" "False" "High" "IsMasterProtein" "P42768" "Actin nucleation-promoting factor WAS OS=Homo sapiens OX=9606 GN=WAS PE=1 SV=4" "0.000" "False" "24.679" "9" "3" "4" "3" "502" "52.9" "6.64" "14.55" "3" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00568, Pf00786, Pf02205" "7454" "ENSG00000015285" "WAS" "hsa:7454; P42768; Q9BU11; Q9UNJ9" "Pathogenic Escherichia coli infection; Complement system; Chemokine signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; T-cell receptor signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Generation of second messenger molecules; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOJ GTPase cycle" "13" "0" "1.037" "1.071" "1.142" "1.005" "1.034" "1.059" "0.902" "1.022" "1.624" "250.2" "259.6" "268.1" "285.8" "251.6" "258.7" "264.9" "225.7" "255.7" "406.3" "" "" "" "" "" "" "" "" "" "" "132.5" "143.9" "153.5" "131.6" "136.1" "143.9" "155.9" "123.2" "143.5" "406.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3614438977501336635" "False" "High" "IsMasterProtein" "Q92558" "Actin-binding protein WASF1 OS=Homo sapiens OX=9606 GN=WASF1 PE=1 SV=1" "0.000" "False" "24.678" "12" "6" "8" "6" "559" "61.6" "6.46" "17.07" "6" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf02205" "8936" "ENSG00000112290" "WASF1" "E1P5F2; hsa:8936; Q5SZK7; Q92558" "VEGFA-VEGFR2 signaling; Regulation of actin cytoskeleton" "RAC1 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway" "8" "0" "1.036" "0.993" "0.972" "0.987" "0.992" "1.033" "0.861" "1.007" "0.972" "275.3" "285.1" "273.4" "267.5" "271.7" "273.0" "284.4" "236.9" "277.3" "267.6" "" "" "" "" "" "" "" "" "" "" "145.8" "158.1" "156.6" "123.2" "147.0" "151.9" "167.4" "129.3" "155.6" "267.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1311899877800093537" "False" "High" "IsMasterProtein" "Q9H0K6" "Pseudouridylate synthase PUS7L OS=Homo sapiens OX=9606 GN=PUS7L PE=1 SV=1" "0.000" "False" "24.562" "10" "8" "9" "8" "701" "80.6" "7.56" "20.40" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01142" "83448" "ENSG00000129317" "PUS7L" "B3KUJ1; hsa:83448; Q05CU0; Q6AHZ3; Q6NUP2; Q9H0K6" "" "" "0" "0" "1.141" "1.105" "1.199" "1.240" "1.376" "1.171" "1.025" "1.178" "1.200" "221.4" "252.5" "244.5" "265.4" "274.4" "304.7" "259.2" "226.9" "260.6" "265.5" "" "" "" "" "" "" "" "" "" "" "117.2" "140.0" "140.1" "122.2" "148.5" "169.5" "152.6" "123.9" "146.2" "265.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174444924925407144" "False" "High" "IsMasterProtein" "P61088" "Ubiquitin-conjugating enzyme E2 N OS=Homo sapiens OX=9606 GN=UBE2N PE=1 SV=1" "0.000" "False" "24.550" "35" "5" "14" "5" "152" "17.1" "6.57" "36.54" "5" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00179" "7334" "ENSG00000177889" "UBE2N" "hsa:7334; P61088; Q16781; Q53Y81" "IL-1 signaling pathway; Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway; Prader-Willi and Angelman syndrome; 3q29 copy number variation syndrome" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; FCERI mediated NF-kB activation; Downstream TCR signaling; E3 ubiquitin ligases ubiquitinate target proteins; Antigen processing: Ubiquitination & Proteasome degradation; CLEC7A (Dectin-1) signaling; Aggrephagy; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; TAK1-dependent IKK and NF-kappa-B activation ; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; activated TAK1 mediates p38 MAPK activation; Nonhomologous End-Joining (NHEJ); Formation of Incision Complex in GG-NER; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "28" "0" "1.034" "1.126" "1.195" "1.151" "1.144" "1.060" "1.148" "1.000" "0.687" "1380.0" "1426.3" "1554.3" "1649.2" "1588.9" "1578.7" "1462.7" "1584.2" "1380.4" "948.4" "" "" "" "" "" "" "" "" "" "" "730.7" "790.8" "890.1" "759.5" "859.6" "878.1" "860.9" "864.7" "774.4" "948.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-327475496585371320" "False" "High" "IsMasterProtein" "Q9BWD1" "Acetyl-CoA acetyltransferase, cytosolic OS=Homo sapiens OX=9606 GN=ACAT2 PE=1 SV=2" "0.000" "False" "24.536" "13" "6" "14" "6" "397" "41.3" "6.92" "40.44" "6" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00108, Pf02803" "39" "ENSG00000120437" "ACAT2" "B7Z233; E1P5B1; hsa:39; Q16146; Q5TCL7; Q8TDM4; Q9BWD1" "Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol metabolism; Cholesterol biosynthesis pathway in hepatocytes; Enterocyte cholesterol metabolism" "Cholesterol biosynthesis" "6" "0" "0.932" "0.962" "0.858" "0.914" "0.948" "1.019" "0.927" "0.932" "0.499" "2749.0" "2562.2" "2645.1" "2359.4" "2511.3" "2607.2" "2801.6" "2549.3" "2563.3" "1370.6" "" "" "" "" "" "" "" "" "" "" "1455.6" "1420.5" "1514.9" "1086.6" "1358.7" "1450.2" "1648.8" "1391.6" "1438.0" "1370.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-573717286669998035" "False" "High" "IsMasterProtein" "Q9BY43" "Charged multivesicular body protein 4a OS=Homo sapiens OX=9606 GN=CHMP4A PE=1 SV=3" "0.000" "False" "24.476" "26" "6" "7" "6" "222" "25.1" "4.70" "18.94" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "29082" "ENSG00000254505; ENSG00000285302" "CHMP4A" "hsa:29082; Q14D22; Q32Q79; Q86SZ8; Q96QJ9; Q9BY43; Q9P026" "" "HCMV Late Events; Late endosomal microautophagy; Pyroptosis; Sealing of the nuclear envelope (NE) by ESCRT-III; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "9" "0" "1.036" "1.085" "1.065" "0.953" "0.960" "1.005" "1.159" "0.977" "0.433" "639.0" "662.3" "693.3" "680.2" "609.1" "613.3" "641.9" "740.4" "624.4" "276.4" "" "" "" "" "" "" "" "" "" "" "338.3" "367.2" "397.1" "313.3" "329.6" "341.1" "377.8" "404.2" "350.3" "276.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7376822484090122143" "False" "High" "IsMasterProtein" "P05166" "Propionyl-CoA carboxylase beta chain, mitochondrial OS=Homo sapiens OX=9606 GN=PCCB PE=1 SV=3" "0.000" "False" "24.470" "12" "6" "6" "6" "539" "58.2" "7.64" "18.24" "6" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf01039" "5096" "ENSG00000114054" "PCCB" "B7Z2Z4; hsa:5096; P05166; Q16813; Q96CX0" "Primary ovarian insufficiency" "Biotin transport and metabolism; Mitochondrial protein degradation; Defective HLCS causes multiple carboxylase deficiency; Propionyl-CoA catabolism" "5" "0" "1.057" "1.085" "1.146" "1.080" "1.035" "1.075" "1.060" "0.959" "0.516" "452.7" "478.5" "491.1" "518.9" "489.0" "468.4" "486.9" "480.1" "434.1" "233.6" "" "" "" "" "" "" "" "" "" "" "239.7" "265.3" "281.3" "239.0" "264.6" "260.5" "286.6" "262.1" "243.5" "233.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3946682035619075212" "False" "High" "IsMasterProtein" "Q00688" "Peptidyl-prolyl cis-trans isomerase FKBP3 OS=Homo sapiens OX=9606 GN=FKBP3 PE=1 SV=1" "0.000" "False" "24.435" "19" "4" "11" "4" "224" "25.2" "9.28" "36.55" "4" "" "nucleus" "other molecular function" "Pf00254, Pf18410" "2287" "ENSG00000100442" "FKBP3" "B2R4Q9; hsa:2287; Q00688; Q14317" "" "" "0" "0" "0.983" "1.005" "0.851" "0.950" "0.940" "0.834" "0.991" "0.942" "0.520" "1667.6" "1639.7" "1675.4" "1419.3" "1584.0" "1568.2" "1390.4" "1652.0" "1571.3" "866.7" "" "" "" "" "" "" "" "" "" "" "883.0" "909.1" "959.5" "653.6" "857.0" "872.3" "818.3" "901.8" "881.4" "866.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1288043512151873046" "False" "High" "IsMasterProtein" "Q8WU39" "Marginal zone B- and B1-cell-specific protein OS=Homo sapiens OX=9606 GN=MZB1 PE=1 SV=1" "0.000" "False" "24.421" "28" "4" "10" "4" "189" "20.7" "5.57" "21.67" "4" "cell organization and biogenesis;other biological processes" "non-structural extracellular;ER/Golgi;other cell component" "" "Pf11938" "51237" "ENSG00000170476" "MZB1" "D2IYS0; hsa:51237; Q7Z6N2; Q8WU39; Q96RL5; Q9P0T3" "" "" "0" "0" "0.994" "1.050" "0.849" "0.983" "0.978" "0.867" "1.001" "0.941" "0.649" "665.1" "660.8" "698.2" "564.6" "653.8" "650.7" "576.7" "666.0" "625.9" "431.4" "" "" "" "" "" "" "" "" "" "" "352.2" "366.4" "399.8" "260.0" "353.7" "362.0" "339.4" "363.5" "351.1" "431.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1708640290626267049" "False" "High" "IsMasterProtein" "P37108" "Signal recognition particle 14 kDa protein OS=Homo sapiens OX=9606 GN=SRP14 PE=1 SV=2" "0.000" "False" "24.418" "37" "4" "9" "4" "136" "14.6" "10.04" "33.73" "4" "other biological processes" "non-structural extracellular;cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02290" "6727" "ENSG00000140319" "SRP14" "B5BUF5; hsa:6727; P37108; Q6B0K5; Q96Q14" "" "Neutrophil degranulation; SRP-dependent cotranslational protein targeting to membrane" "2" "0" "1.048" "1.142" "0.997" "0.962" "0.967" "0.976" "1.107" "1.033" "0.581" "785.3" "822.6" "896.9" "782.9" "755.6" "759.4" "766.7" "869.6" "811.0" "456.1" "" "" "" "" "" "" "" "" "" "" "415.8" "456.1" "513.6" "360.6" "408.8" "422.4" "451.3" "474.7" "455.0" "456.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "562361449972294003" "False" "High" "IsMasterProtein" "O00425" "Insulin-like growth factor 2 mRNA-binding protein 3 OS=Homo sapiens OX=9606 GN=IGF2BP3 PE=1 SV=2" "0.000" "False" "24.368" "11" "5" "6" "5" "579" "63.7" "8.87" "21.05" "5" "protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00076" "10643" "ENSG00000136231" "IGF2BP3" "A0A4Z5; hsa:10643; O00425; Q63HM0; Q6MZZ2; Q86VB1" "" "Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA" "1" "0" "1.477" "1.025" "1.325" "1.251" "1.235" "1.129" "0.490" "1.234" "6.317" "177.1" "261.6" "181.6" "234.7" "221.5" "218.6" "200.0" "86.7" "218.5" "1118.6" "" "" "" "" "" "" "" "" "" "" "93.8" "145.0" "104.0" "108.1" "119.9" "121.6" "117.7" "47.3" "122.6" "1118.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3364566389234349396" "False" "High" "IsMasterProtein" "Q04727" "Transducin-like enhancer protein 4 OS=Homo sapiens OX=9606 GN=TLE4 PE=1 SV=3" "0.000" "False" "24.321" "6" "5" "6" "5" "773" "83.7" "7.50" "18.60" "5" "cell-cell signaling;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf03920" "7091" "ENSG00000106829" "TLE4" "F8W6T6; hsa:7091; Q04727; Q3ZCS1; Q5T1Y2; Q6PCB3; Q9BZ07; Q9BZ08; Q9BZ09; Q9NSL3; Q9ULF9" "" "Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; NOTCH1 Intracellular Domain Regulates Transcription; Repression of WNT target genes" "4" "0" "0.998" "1.003" "0.890" "0.943" "0.976" "0.930" "1.003" "0.976" "0.714" "830.2" "828.8" "832.4" "738.9" "782.7" "809.9" "771.8" "832.6" "810.6" "592.8" "" "" "" "" "" "" "" "" "" "" "439.6" "459.5" "476.7" "340.3" "423.5" "450.5" "454.2" "454.5" "454.7" "592.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-61842363996650095" "False" "High" "IsMasterProtein" "P19623" "Spermidine synthase OS=Homo sapiens OX=9606 GN=SRM PE=1 SV=1" "0.000" "False" "24.281" "23" "6" "11" "6" "302" "33.8" "5.49" "27.99" "6" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf01564, Pf17284" "6723" "ENSG00000116649" "SRM" "B1AKP9; hsa:6723; P19623; Q15511" "Methionine de novo and salvage pathway; Amino acid metabolism" "Metabolism of polyamines" "3" "0" "0.975" "0.955" "0.952" "1.015" "0.986" "0.838" "0.848" "0.962" "0.795" "827.6" "807.0" "790.3" "787.8" "839.7" "815.8" "693.2" "701.7" "796.0" "658.2" "" "" "" "" "" "" "" "" "" "" "438.2" "447.4" "452.6" "362.8" "454.3" "453.8" "408.0" "383.0" "446.5" "658.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-700726988884900620" "False" "High" "IsMasterProtein" "Q9BQ61" "Telomerase RNA component interacting RNase OS=Homo sapiens OX=9606 GN=TRIR PE=1 SV=1" "0.000" "False" "24.262" "21" "4" "6" "4" "176" "18.4" "9.44" "20.60" "4" "RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "" "79002" "ENSG00000123144" "TRIR" "hsa:79002; Q9BQ61" "" "" "0" "0" "1.038" "1.063" "1.008" "1.183" "1.015" "1.008" "1.162" "1.088" "0.399" "916.9" "951.9" "974.6" "924.4" "1084.8" "930.6" "923.9" "1065.5" "997.8" "365.5" "" "" "" "" "" "" "" "" "" "" "485.5" "527.8" "558.1" "425.7" "586.9" "517.7" "543.7" "581.6" "559.8" "365.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2192359693732382121" "False" "High" "IsMasterProtein" "O95433" "Activator of 90 kDa heat shock protein ATPase homolog 1 OS=Homo sapiens OX=9606 GN=AHSA1 PE=1 SV=1" "0.000" "False" "24.246" "14" "5" "8" "5" "338" "38.3" "5.53" "26.74" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi" "other molecular function" "Pf08327, Pf09229" "10598" "ENSG00000100591" "AHSA1" "B2R9L2; B4DUR9; hsa:10598; O95433; Q96IL6; Q9P060" "T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection" "" "1" "0" "0.961" "0.888" "0.922" "0.982" "0.941" "1.001" "0.893" "0.925" "1.146" "718.3" "690.5" "637.7" "662.1" "705.7" "675.5" "719.3" "641.6" "664.7" "822.9" "" "" "" "" "" "" "" "" "" "" "380.3" "382.8" "365.2" "304.9" "381.8" "375.8" "423.3" "350.2" "372.9" "822.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2843591473366045892" "False" "High" "IsMasterProtein" "P62136" "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CA PE=1 SV=1" "0.000" "False" "24.232" "15" "5" "10" "3" "330" "37.5" "6.33" "28.73" "5" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00149, Pf16891" "5499" "ENSG00000172531" "PPP1CA" "A6NNR3; B2R908; hsa:5499; P08129; P20653; P22802; P62136; Q07161" "Sphingolipid pathway; Nicotine effect on dopaminergic neurons; Common pathways underlying drug addiction; Focal adhesion; VEGFA-VEGFR2 signaling; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Netrin-UNC5B signaling pathway; Neuroinflammation and glutamatergic signaling; HDAC6 interactions in the central nervous system" "Triglyceride catabolism; Circadian Clock; Downregulation of TGF-beta receptor signaling; Maturation of hRSV A proteins; DARPP-32 events" "15" "2" "0.946" "1.004" "1.020" "0.984" "1.020" "1.113" "1.077" "1.037" "0.776" "1000.5" "946.9" "1004.4" "1020.6" "984.1" "1021.0" "1113.7" "1077.8" "1037.6" "776.5" "" "" "" "" "" "" "" "" "" "" "529.8" "525.0" "575.2" "470.0" "532.5" "567.9" "655.4" "588.3" "582.1" "776.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5299330729239778052" "False" "High" "IsMasterProtein" "Q6PFW1" "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 OS=Homo sapiens OX=9606 GN=PPIP5K1 PE=1 SV=1" "0.000" "False" "24.220" "4" "5" "6" "1" "1433" "159.4" "5.40" "19.38" "5" "other metabolic processes" "plasma membrane;other membranes;cytosol" "kinase activity;other molecular function" "Pf00328, Pf18086" "9677" "ENSG00000168781" "PPIP5K1" "hsa:9677; O15082; Q5HYF8; Q6PFW1; Q7Z3A7; Q86TE7; Q86UV3; Q86UV4; Q86XW8; Q8IZN0" "" "Synthesis of pyrophosphates in the cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3220209801310809840" "False" "High" "IsMasterProtein" "P60891" "Ribose-phosphate pyrophosphokinase 1 OS=Homo sapiens OX=9606 GN=PRPS1 PE=1 SV=2" "0.000" "False" "24.127" "21" "7" "10" "3" "318" "34.8" "6.98" "23.98" "7" "other metabolic processes;developmental processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf13793, Pf14572" "5631" "ENSG00000147224" "PRPS1" "B1ALA8; B2R6T7; B4DNL6; D3DUX6; hsa:5631; P09329; P60891" "" "5-Phosphoribose 1-diphosphate biosynthesis" "1" "2" "1.032" "0.985" "1.010" "1.045" "0.961" "0.971" "0.965" "0.813" "0.539" "424.6" "438.1" "418.2" "429.0" "443.8" "408.1" "412.2" "409.7" "345.2" "228.8" "" "" "" "" "" "" "" "" "" "" "224.8" "242.9" "239.5" "197.6" "240.1" "227.0" "242.6" "223.6" "193.6" "228.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8500687369034294287" "False" "High" "IsMasterProtein" "P62820" "Ras-related protein Rab-1A OS=Homo sapiens OX=9606 GN=RAB1A PE=1 SV=3" "0.000" "False" "24.126" "30" "7" "17" "2" "205" "22.7" "6.21" "47.15" "7" "cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5861" "ENSG00000138069" "RAB1A" "hsa:5861; P11476; P62820; Q6FIE7; Q96N61; Q9Y3T2" "" "RAB GEFs exchange GTP for GDP on RABs; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; COPII-mediated vesicle transport; RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization" "6" "0" "0.919" "0.962" "0.905" "0.950" "0.923" "0.868" "0.932" "0.833" "0.503" "821.4" "755.0" "790.3" "743.4" "780.0" "758.1" "712.9" "765.8" "684.4" "413.4" "" "" "" "" "" "" "" "" "" "" "434.9" "418.6" "452.6" "342.4" "422.0" "421.7" "419.6" "418.0" "383.9" "413.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1684590373995147366" "False" "High" "IsMasterProtein" "P35237" "Serpin B6 OS=Homo sapiens OX=9606 GN=SERPINB6 PE=1 SV=3" "0.000" "False" "24.118" "16" "5" "7" "4" "376" "42.6" "5.27" "14.59" "5" "stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00079" "5269" "ENSG00000124570" "SERPINB6" "B2RBA8; hsa:5269; P35237; Q59F97; Q5TD06; Q7Z2Y7; Q96J44; Q9UDI7" "Ectoderm differentiation" "Neutrophil degranulation; Dissolution of Fibrin Clot" "3" "0" "1.004" "0.934" "1.060" "1.076" "1.023" "1.054" "1.044" "1.169" "0.601" "189.7" "190.6" "177.2" "201.0" "204.1" "194.1" "200.0" "198.1" "221.9" "113.9" "" "" "" "" "" "" "" "" "" "" "100.5" "105.6" "101.5" "92.6" "110.4" "108.0" "117.7" "108.2" "124.5" "113.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4163681238843766636" "False" "High" "IsMasterProtein" "Q13144" "Translation initiation factor eIF2B subunit epsilon OS=Homo sapiens OX=9606 GN=EIF2B5 PE=1 SV=3" "0.000" "False" "24.112" "5" "3" "4" "3" "721" "80.3" "5.08" "14.39" "3" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf02020" "8893" "ENSG00000145191" "EIF2B5" "hsa:8893; Q13144; Q541Z1; Q96D04" "Translation factors; MicroRNAs in cardiomyocyte hypertrophy; DYRK1A involvement regarding cell proliferation in brain development; Primary ovarian insufficiency" "Recycling of eIF2:GDP" "5" "0" "1.025" "0.984" "0.906" "0.941" "0.991" "0.774" "0.755" "0.805" "0.881" "624.3" "639.7" "614.1" "565.6" "587.4" "618.4" "483.1" "471.1" "502.3" "550.2" "" "" "" "" "" "" "" "" "" "" "330.6" "354.6" "351.7" "260.5" "317.8" "344.0" "284.3" "257.2" "281.8" "550.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8059296943260836861" "False" "High" "IsMasterProtein" "Q15286" "Ras-related protein Rab-35 OS=Homo sapiens OX=9606 GN=RAB35 PE=1 SV=1" "0.000" "False" "24.050" "26" "5" "9" "4" "201" "23.0" "8.29" "22.62" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "11021" "ENSG00000111737" "RAB35" "B2R6E0; B4E390; hsa:11021; Q15286" "" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; TBC/RABGAPs" "3" "0" "0.842" "0.974" "0.937" "0.797" "0.968" "0.846" "0.925" "0.950" "0.634" "575.3" "484.6" "560.1" "539.3" "458.5" "556.9" "487.0" "532.3" "546.8" "364.9" "" "" "" "" "" "" "" "" "" "" "304.6" "268.7" "320.8" "248.4" "248.1" "309.8" "286.6" "290.6" "306.8" "364.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5860856138791644160" "False" "High" "IsMasterProtein" "Q9Y5A9" "YTH domain-containing family protein 2 OS=Homo sapiens OX=9606 GN=YTHDF2 PE=1 SV=2" "0.000" "False" "24.037" "12" "7" "9" "4" "579" "62.3" "8.79" "26.72" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04146" "51441" "ENSG00000198492" "YTHDF2" "A6NKG4; A8K966; B4E1G7; D3DPM8; hsa:51441; Q5VSZ9; Q8TDH0; Q9BUJ5; Q9Y5A9" "" "" "0" "0" "0.912" "1.022" "0.979" "0.946" "1.002" "1.023" "1.227" "1.083" "0.750" "433.1" "395.0" "442.7" "424.0" "409.6" "434.1" "443.1" "531.2" "469.2" "324.6" "" "" "" "" "" "" "" "" "" "" "229.3" "219.0" "253.5" "195.3" "221.6" "241.4" "260.8" "290.0" "263.2" "324.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3450396974392384393" "False" "High" "IsMasterProtein" "Q13112" "Chromatin assembly factor 1 subunit B OS=Homo sapiens OX=9606 GN=CHAF1B PE=1 SV=1" "0.000" "False" "24.016" "13" "7" "9" "7" "559" "61.5" "7.50" "28.45" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf00400, Pf15512" "8208" "ENSG00000159259" "CHAF1B" "hsa:8208; Q13112; Q99548" "" "" "0" "0" "0.967" "1.031" "1.002" "0.956" "1.039" "0.998" "1.075" "1.071" "0.634" "1000.6" "967.4" "1031.3" "1002.4" "957.0" "1039.3" "998.3" "1075.2" "1071.6" "634.8" "" "" "" "" "" "" "" "" "" "" "529.8" "536.4" "590.6" "461.6" "517.8" "578.1" "587.5" "586.9" "601.1" "634.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9217624131527771053" "False" "High" "IsMasterProtein" "O00330" "Pyruvate dehydrogenase protein X component, mitochondrial OS=Homo sapiens OX=9606 GN=PDHX PE=1 SV=3" "0.000" "False" "24.006" "13" "7" "8" "7" "501" "54.1" "8.66" "23.24" "7" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00198, Pf00364, Pf02817" "8050" "ENSG00000110435" "PDHX" "B4DW62; D3DR11; E9PB14; E9PBP7; hsa:8050; O00330; O60221; Q96FV8; Q99783" "Amino acid metabolism" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "5" "0" "0.952" "1.035" "1.006" "0.984" "1.073" "1.004" "0.980" "0.937" "0.513" "685.3" "652.3" "709.2" "689.1" "674.5" "735.1" "688.2" "671.9" "642.4" "351.4" "" "" "" "" "" "" "" "" "" "" "362.9" "361.7" "406.2" "317.4" "364.9" "408.9" "405.0" "366.8" "360.3" "351.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6844923263172623256" "False" "High" "IsMasterProtein" "Q9BXP5" "Serrate RNA effector molecule homolog OS=Homo sapiens OX=9606 GN=SRRT PE=1 SV=1" "0.000" "False" "23.976" "7" "7" "7" "7" "876" "100.6" "5.96" "18.48" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04959, Pf12066" "51593" "ENSG00000087087" "SRRT" "A4D2E5; A4D2E6; A6NK22; B4DJL4; B4DZA6; hsa:51593; O95808; Q32MI4; Q6NT74; Q8TDQ5; Q9BWP6; Q9BXP4; Q9BXP5; Q9Y4S4" "" "mRNA Splicing - Major Pathway; RNA polymerase II transcribes snRNA genes" "2" "0" "1.139" "1.115" "1.291" "0.994" "1.009" "1.138" "0.653" "1.155" "8.377" "251.7" "286.6" "280.5" "324.8" "250.2" "253.9" "286.3" "164.4" "290.7" "2108.4" "" "" "" "" "" "" "" "" "" "" "133.3" "158.9" "160.6" "149.6" "135.4" "141.2" "168.5" "89.7" "163.1" "2108.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9162404171034655345" "False" "High" "IsMasterProtein" "Q9Y223" "Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase OS=Homo sapiens OX=9606 GN=GNE PE=1 SV=1" "0.000" "False" "23.954" "8" "6" "9" "6" "722" "79.2" "6.80" "27.63" "6" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf00480, Pf02350" "10020" "ENSG00000159921" "GNE" "A6PZH2; A6PZH3; A7UNU7; B2R6E1; B7Z372; B7Z428; D3DRP7; F5H499; H0YFA7; hsa:10020; Q0VA94; Q9Y223" "Sialylation" "Sialic acid metabolism; Defective GNE causes sialuria, NK and IBM2" "3" "0" "1.026" "0.993" "1.017" "1.041" "1.054" "1.016" "1.065" "0.999" "0.784" "806.3" "827.3" "800.4" "819.8" "839.5" "849.7" "819.1" "859.1" "805.3" "631.9" "" "" "" "" "" "" "" "" "" "" "426.9" "458.7" "458.4" "377.5" "454.2" "472.6" "482.1" "468.9" "451.8" "631.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4945442823809026460" "False" "High" "IsMasterProtein" "O95861" "3'(2'),5'-bisphosphate nucleotidase 1 OS=Homo sapiens OX=9606 GN=BPNT1 PE=1 SV=1" "0.000" "False" "23.909" "20" "6" "9" "6" "308" "33.4" "5.69" "23.31" "6" "other metabolic processes;developmental processes" "cytosol" "other molecular function" "Pf00459" "10380" "ENSG00000162813" "BPNT1" "A8K7C8; B4DPS5; B4DUS9; D3DTA9; hsa:10380; O95861; Q8WVL5; Q9UGJ3" "" "Cytosolic sulfonation of small molecules" "1" "0" "0.968" "0.988" "0.959" "1.042" "1.026" "1.008" "0.969" "1.008" "0.822" "844.7" "817.4" "834.5" "810.4" "880.5" "866.3" "851.2" "818.4" "851.5" "694.5" "" "" "" "" "" "" "" "" "" "" "447.3" "453.2" "477.9" "373.2" "476.4" "481.9" "500.9" "446.7" "477.7" "694.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "412989267492622894" "False" "High" "IsMasterProtein" "Q12874" "Splicing factor 3A subunit 3 OS=Homo sapiens OX=9606 GN=SF3A3 PE=1 SV=1" "0.000" "False" "23.902" "15" "7" "9" "7" "501" "58.8" "5.38" "19.41" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf11931, Pf12108, Pf13297, Pf16837" "10946" "ENSG00000183431" "SF3A3" "D3DPT5; hsa:10946; Q12874; Q15460; Q5VT87" "Exercise-induced circadian regulation; mRNA processing" "mRNA Splicing - Major Pathway" "3" "0" "0.977" "1.097" "1.009" "1.056" "1.066" "1.039" "1.080" "0.991" "1.705" "373.2" "364.5" "409.2" "376.6" "394.0" "397.8" "387.9" "403.0" "369.7" "636.3" "" "" "" "" "" "" "" "" "" "" "197.6" "202.1" "234.4" "173.4" "213.2" "221.3" "228.3" "220.0" "207.4" "636.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5381164833794741619" "False" "High" "IsMasterProtein" "Q9Y5K6" "CD2-associated protein OS=Homo sapiens OX=9606 GN=CD2AP PE=1 SV=1" "0.000" "False" "23.873" "9" "6" "6" "6" "639" "71.4" "6.40" "20.12" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf07653, Pf14604" "23607" "ENSG00000198087" "CD2AP" "A6NL34; hsa:23607; Q5VYA3; Q9UG97; Q9Y5K6" "Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome; Genes controlling nephrogenesis; GDNF signaling" "Nephrin family interactions" "5" "0" "0.923" "0.990" "1.059" "1.006" "1.035" "1.270" "1.331" "1.261" "1.172" "931.8" "860.3" "922.0" "987.2" "937.5" "964.2" "1183.5" "1239.8" "1174.8" "1091.8" "" "" "" "" "" "" "" "" "" "" "493.4" "477.0" "528.0" "454.6" "507.2" "536.3" "696.5" "676.7" "659.0" "1091.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9199223731198630068" "False" "High" "IsMasterProtein" "Q9UIJ7" "GTP:AMP phosphotransferase AK3, mitochondrial OS=Homo sapiens OX=9606 GN=AK3 PE=1 SV=4" "0.000" "False" "23.868" "33" "8" "11" "8" "227" "25.6" "9.16" "28.06" "8" "other metabolic processes;stress response" "mitochondrion;other cell component" "kinase activity;other molecular function" "Pf00406, Pf05191" "50808" "ENSG00000147853" "AK3" "B4DP58; D3DRI1; E7ET30; hsa:50808; Q5VYW6; Q9H576; Q9HC01; Q9NPB4; Q9UIJ7" "" "Factors involved in megakaryocyte development and platelet production" "1" "0" "1.078" "1.090" "1.118" "1.135" "1.109" "1.112" "1.086" "1.038" "0.643" "757.5" "816.2" "825.8" "847.0" "859.8" "839.7" "842.3" "822.9" "786.6" "487.1" "" "" "" "" "" "" "" "" "" "" "401.1" "452.5" "472.9" "390.1" "465.2" "467.1" "495.7" "449.2" "441.3" "487.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-579275288277334412" "False" "High" "IsMasterProtein" "P46736" "Lys-63-specific deubiquitinase BRCC36 OS=Homo sapiens OX=9606 GN=BRCC3 PE=1 SV=2" "0.000" "False" "23.859" "24" "6" "7" "6" "316" "36.0" "5.92" "17.16" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01398, Pf18110" "79184" "ENSG00000185515" "BRCC3" "A6QRF8; A6QRF9; A8MUX5; A8MWH0; A9Z1Y0; A9Z1Y5; B1B062; B4DQN7; hsa:79184; P46736; Q16107; Q53YX5; Q9BTZ6" "5q35 copy number variation" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs" "6" "0" "1.037" "0.973" "1.077" "1.040" "1.023" "1.083" "0.963" "1.006" "0.783" "393.2" "407.7" "382.7" "423.6" "409.0" "402.4" "426.0" "378.6" "395.7" "307.7" "" "" "" "" "" "" "" "" "" "" "208.2" "226.0" "219.2" "195.1" "221.3" "223.8" "250.7" "206.7" "222.0" "307.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5706954355209209913" "False" "High" "IsMasterProtein" "Q99436" "Proteasome subunit beta type-7 OS=Homo sapiens OX=9606 GN=PSMB7 PE=1 SV=1" "0.000" "False" "23.845" "21" "5" "12" "5" "277" "29.9" "7.68" "32.11" "5" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf12465" "5695" "ENSG00000136930" "PSMB7" "B4E0P1; hsa:5695; Q5TBG6; Q96AG8; Q99436; Q9BWA7" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "ER-Phagosome pathway; Neutrophil degranulation; MAPK6/MAPK4 signaling; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "0.960" "0.931" "0.910" "0.962" "0.941" "1.016" "0.981" "0.976" "0.499" "2024.1" "1942.4" "1885.3" "1842.1" "1948.2" "1904.2" "2056.9" "1986.2" "1976.1" "1010.5" "" "" "" "" "" "" "" "" "" "" "1071.8" "1076.9" "1079.7" "848.3" "1054.0" "1059.2" "1210.5" "1084.2" "1108.6" "1010.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8144155955974209704" "False" "High" "IsMasterProtein" "P16220" "Cyclic AMP-responsive element-binding protein 1 OS=Homo sapiens OX=9606 GN=CREB1 PE=1 SV=3" "0.000" "False" "23.825" "15" "3" "6" "2" "327" "35.1" "5.27" "18.97" "3" "cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf02173" "1385" "ENSG00000118260" "CREB1" "hsa:1385; P16220; P21934; Q6V963; Q9UMA7" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; Energy metabolism; miRNAs involved in DNA damage response; Folate-alcohol and cancer pathway hypotheses; Sterol regulatory element-binding proteins (SREBP) signaling; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling pathway; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; MFAP5-mediated ovarian cancer cell motility and invasiveness; Ovarian infertility; MECP2 and associated Rett syndrome; Transcription factor regulation in adipogenesis; BDNF-TrkB signaling; ERK pathway in Huntington's disease; VEGFA-VEGFR2 signaling; Mitochondrial gene expression; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prion disease pathway; p38 MAPK signaling pathway; NO/cGMP/PKG mediated neuroprotection; White fat cell differentiation; PI3K-Akt signaling pathway; Phosphodiesterases in neuronal function; Acute viral myocarditis; Thermogenesis; EGF/EGFR signaling pathway; G1 to S cell cycle control; Fragile X syndrome; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; Hepatitis B infection; Melanoma; mBDNF and proBDNF regulation of GABA neurotransmission; CAMKK2 pathway; GPR143 in melanocytes and retinal pigment epithelium cells; Galanin receptor pathway; Neuroinflammation and glutamatergic signaling; Vasopressin-regulated water reabsorption; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Rubinstein-Taybi syndrome 1; Smith-Magenis and Potocki-Lupski syndrome copy number variation; Interferon type I signaling pathways; T-cell receptor signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 4/6/7 and NR3C signaling" "ADORA2B mediated anti-inflammatory cytokines production; FCGR3A-mediated IL10 synthesis; HCMV Early Events; AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; NGF-stimulated transcription; Heme signaling; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; MECP2 regulates transcription of neuronal ligands; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; NCAM signaling for neurite out-growth; Regulation of MECP2 expression and activity; Transcriptional regulation of granulopoiesis; CREB phosphorylation; Gastrin-CREB signalling pathway via PKC and MAPK; NOTCH2 intracellular domain regulates transcription; MECP2 regulates neuronal receptors and channels; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of Adenylate Cyclase; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde; PKA-mediated phosphorylation of CREB; CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling; MECP2 regulates transcription factors" "85" "0" "0.949" "0.983" "1.044" "0.973" "1.003" "1.002" "0.860" "0.901" "0.918" "320.8" "304.4" "315.2" "334.9" "312.2" "321.8" "321.4" "276.0" "289.1" "294.5" "" "" "" "" "" "" "" "" "" "" "169.8" "168.7" "180.5" "154.2" "168.9" "179.0" "189.2" "150.7" "162.2" "294.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8197939441703168183" "False" "High" "IsMasterProtein" "Cont_P12763" "Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2" "0.000" "True" "23.818" "16" "5" "9" "5" "359" "38.4" "5.50" "27.21" "5" "stress response;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component" "enzyme regulator activity" "Pf00031" "280988" "ENSBTAG00000000522" "AHSG" "A6QLF7; B0JYN6; bta:280988; P12763" "" "Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "4" "0" "0.988" "0.943" "1.192" "1.612" "1.433" "1.588" "1.593" "1.729" "0.642" "691.7" "683.1" "652.3" "824.4" "1114.9" "991.0" "1098.2" "1101.7" "1195.7" "444.0" "" "" "" "" "" "" "" "" "" "" "366.3" "378.8" "373.6" "379.6" "603.2" "551.2" "646.3" "601.4" "670.7" "444.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5466542288326959120" "False" "High" "IsMasterProtein" "P59998" "Actin-related protein 2/3 complex subunit 4 OS=Homo sapiens OX=9606 GN=ARPC4 PE=1 SV=3" "0.000" "False" "23.811" "27" "5" "13" "5" "168" "19.7" "8.43" "36.26" "5" "cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf05856" "10093" "ENSG00000241553" "ARPC4" "C9JWM7; E7ETI0; F6TTL5; hsa:10093; O15509; P59998; Q6P0W5; Q96QJ3" "Pathogenic Escherichia coli infection" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "6" "0" "0.953" "0.930" "0.997" "1.022" "1.013" "1.065" "0.976" "0.991" "0.556" "750.4" "715.2" "697.6" "748.2" "766.7" "760.2" "799.3" "732.0" "744.0" "417.5" "" "" "" "" "" "" "" "" "" "" "397.3" "396.5" "399.5" "344.6" "414.8" "422.8" "470.4" "399.6" "417.3" "417.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4617078502424805251" "False" "High" "IsMasterProtein" "Q9H857" "5'-nucleotidase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=NT5DC2 PE=1 SV=1" "0.000" "False" "23.802" "12" "7" "9" "7" "520" "60.7" "6.77" "21.56" "7" "" "" "other molecular function" "Pf05761" "64943" "ENSG00000168268" "NT5DC2" "C9JTZ6; E9PAL9; hsa:64943; O95888; Q96C80; Q9H857; Q9H9Z8" "" "" "0" "0" "1.103" "1.086" "1.055" "1.090" "1.098" "1.011" "1.034" "0.925" "0.748" "776.0" "855.6" "843.1" "819.0" "845.9" "852.3" "784.5" "802.7" "718.0" "580.6" "" "" "" "" "" "" "" "" "" "" "410.9" "474.4" "482.9" "377.2" "457.7" "474.1" "461.7" "438.2" "402.8" "580.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3338411764392514561" "False" "High" "IsMasterProtein" "P45954" "Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADSB PE=1 SV=1" "0.000" "False" "23.800" "15" "5" "8" "5" "432" "47.5" "6.99" "24.18" "5" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00441, Pf02770, Pf02771" "36" "ENSG00000196177" "ACADSB" "B4DQ51; hsa:36; P45954; Q5SQN6; Q96CX7" "Valproic acid pathway" "Mitochondrial protein degradation; Branched-chain amino acid catabolism" "3" "0" "0.977" "0.886" "0.958" "0.991" "0.910" "0.900" "0.900" "0.845" "0.645" "446.9" "436.7" "396.1" "428.1" "442.8" "406.7" "402.2" "402.2" "377.6" "288.3" "" "" "" "" "" "" "" "" "" "" "236.7" "242.1" "226.8" "197.2" "239.6" "226.2" "236.7" "219.5" "211.8" "288.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4317219429199659424" "False" "High" "IsMasterProtein" "Q9H6Z4" "Ran-binding protein 3 OS=Homo sapiens OX=9606 GN=RANBP3 PE=1 SV=1" "0.000" "False" "23.796" "15" "7" "14" "7" "567" "60.2" "4.78" "34.56" "7" "transport" "nucleus;other cell component" "other molecular function" "Pf00638" "8498" "ENSG00000031823" "RANBP3" "B2RAT8; hsa:8498; O60405; O75759; O75760; Q9BT47; Q9H6Z4; Q9UG74" "" "" "0" "0" "0.989" "1.022" "1.032" "1.012" "0.984" "1.015" "1.044" "1.004" "0.670" "1144.9" "1132.0" "1169.9" "1182.0" "1158.4" "1126.7" "1161.5" "1194.7" "1149.2" "767.1" "" "" "" "" "" "" "" "" "" "" "606.2" "627.6" "670.0" "544.3" "626.7" "626.7" "683.6" "652.1" "644.7" "767.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7858307060055438950" "False" "High" "IsMasterProtein" "Q9HAB8" "Phosphopantothenate--cysteine ligase OS=Homo sapiens OX=9606 GN=PPCS PE=1 SV=2" "0.000" "False" "23.734" "17" "7" "8" "7" "311" "34.0" "6.71" "24.98" "7" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04127" "79717" "ENSG00000127125" "PPCS" "hsa:79717; Q3KQT2; Q5VVM0; Q9HAB8" "" "Coenzyme A biosynthesis" "1" "0" "1.015" "0.996" "1.106" "1.062" "1.061" "1.059" "0.972" "0.981" "0.720" "532.2" "540.1" "529.9" "588.5" "565.4" "564.5" "563.4" "517.1" "522.1" "383.3" "" "" "" "" "" "" "" "" "" "" "281.8" "299.5" "303.5" "271.0" "305.9" "314.0" "331.6" "282.2" "292.9" "383.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5314781854584049203" "False" "High" "IsMasterProtein" "O75436" "Vacuolar protein sorting-associated protein 26A OS=Homo sapiens OX=9606 GN=VPS26A PE=1 SV=2" "0.000" "False" "23.731" "21" "7" "8" "6" "327" "38.1" "6.57" "23.92" "7" "transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf03643" "9559" "ENSG00000122958" "VPS26A" "A8MZ56; B2RDD3; hsa:9559; O75436; Q8TBH4; Q9H982" "" "WNT ligand biogenesis and trafficking" "1" "1" "1.010" "0.935" "1.033" "1.015" "1.068" "1.010" "0.990" "0.996" "0.654" "1036.1" "1046.4" "968.6" "1070.8" "1051.5" "1106.2" "1046.8" "1025.8" "1031.7" "677.6" "" "" "" "" "" "" "" "" "" "" "548.6" "580.2" "554.7" "493.1" "568.9" "615.3" "616.1" "559.9" "578.8" "677.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5299507636150983864" "False" "High" "IsMasterProtein" "Q9Y697" "Cysteine desulfurase OS=Homo sapiens OX=9606 GN=NFS1 PE=1 SV=3" "0.000" "False" "23.531" "10" "4" "6" "4" "457" "50.2" "8.31" "19.95" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00266" "9054" "ENSG00000244005" "NFS1" "B3KMA5; B4DXK9; E1P5R8; F5GYK5; hsa:9054; Q6P0L8; Q9NTZ5; Q9Y481; Q9Y697" "Iron-sulfur cluster biogenesis" "" "1" "0" "0.972" "0.961" "1.081" "1.074" "0.959" "0.909" "0.966" "0.938" "0.787" "380.9" "370.1" "366.2" "411.9" "408.9" "365.3" "346.4" "367.9" "357.5" "299.9" "" "" "" "" "" "" "" "" "" "" "201.7" "205.2" "209.7" "189.7" "221.2" "203.2" "203.9" "200.8" "200.5" "299.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5620405547330282270" "False" "High" "IsMasterProtein" "Q7Z4V5" "Hepatoma-derived growth factor-related protein 2 OS=Homo sapiens OX=9606 GN=HDGFL2 PE=1 SV=1" "0.000" "False" "23.529" "10" "8" "12" "7" "671" "74.3" "7.49" "32.71" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00855, Pf11467" "84717" "ENSG00000167674" "HDGFL2" "I3L080; K7EQZ6; Q7Z4V5; Q96GI5; Q9BW08" "" "" "0" "0" "0.940" "1.038" "0.967" "1.035" "0.974" "1.132" "1.242" "1.273" "0.468" "704.8" "662.8" "731.7" "681.7" "729.2" "686.5" "797.8" "875.7" "897.0" "329.6" "" "" "" "" "" "" "" "" "" "" "373.2" "367.5" "419.0" "313.9" "394.5" "381.9" "469.5" "478.0" "503.2" "329.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7690147936594120282" "False" "High" "IsMasterProtein" "P08397" "Porphobilinogen deaminase OS=Homo sapiens OX=9606 GN=HMBS PE=1 SV=2" "0.000" "False" "23.523" "18" "7" "7" "7" "361" "39.3" "7.18" "22.85" "7" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01379, Pf03900" "3145" "ENSG00000256269" "HMBS" "A8K2L0; G3V1P4; G5EA58; hsa:3145; P08396; P08397; Q16012" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "Heme biosynthesis" "3" "0" "1.023" "1.066" "1.026" "1.001" "1.109" "1.074" "1.094" "1.056" "0.672" "537.6" "549.9" "572.9" "551.7" "538.1" "596.0" "577.4" "588.4" "567.8" "361.1" "" "" "" "" "" "" "" "" "" "" "284.7" "304.9" "328.1" "254.1" "291.1" "331.5" "339.8" "321.2" "318.5" "361.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7003283534467846840" "False" "High" "IsMasterProtein" "P40937" "Replication factor C subunit 5 OS=Homo sapiens OX=9606 GN=RFC5 PE=1 SV=1" "0.000" "False" "23.492" "16" "5" "8" "5" "340" "38.5" "7.20" "22.10" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004, Pf08542" "5985" "ENSG00000111445" "RFC5" "A8MZ62; B3KSX8; hsa:5985; P40937" "Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "28" "0" "0.986" "1.002" "1.065" "1.040" "1.073" "0.897" "0.889" "0.891" "1.217" "632.8" "624.0" "633.9" "674.0" "658.3" "678.7" "567.6" "562.5" "563.8" "770.4" "" "" "" "" "" "" "" "" "" "" "335.0" "346.0" "363.0" "310.4" "356.2" "377.5" "334.0" "307.0" "316.3" "770.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6148920523022948324" "False" "High" "IsMasterProtein" "P35606" "Coatomer subunit beta' OS=Homo sapiens OX=9606 GN=COPB2 PE=1 SV=2" "0.000" "False" "23.478" "7" "6" "10" "6" "906" "102.4" "5.27" "19.98" "6" "transport" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00400, Pf04053" "9276" "ENSG00000184432" "COPB2" "B4DZI8; hsa:9276; P35606" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "2" "0" "1.002" "1.087" "0.969" "1.002" "1.081" "1.073" "1.028" "1.001" "1.242" "393.1" "393.8" "427.2" "381.1" "394.0" "425.1" "421.7" "404.3" "393.7" "488.2" "" "" "" "" "" "" "" "" "" "" "208.2" "218.3" "244.6" "175.5" "213.2" "236.4" "248.2" "220.7" "220.9" "488.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8133937274084103067" "False" "High" "IsMasterProtein" "P28074" "Proteasome subunit beta type-5 OS=Homo sapiens OX=9606 GN=PSMB5 PE=1 SV=3" "0.000" "False" "23.451" "21" "5" "8" "5" "263" "28.5" "6.92" "24.71" "5" "protein metabolism;other metabolic processes;stress response" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00227" "5693" "ENSG00000100804" "PSMB5" "B2R4N9; B4DUM9; D3DS43; E9PAV2; hsa:5693; P28074; Q16242; Q6PEW2; Q7Z3B5; Q86T01; Q9TNN9" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Asymmetric localization of PCP proteins; Degradation of DVL; ER-Phagosome pathway; Regulation of expression of SLITs and ROBOs; MAPK6/MAPK4 signaling; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "0.975" "0.990" "0.913" "0.970" "0.994" "1.026" "1.026" "0.992" "0.636" "418.3" "407.9" "414.2" "382.0" "405.7" "415.8" "429.3" "429.3" "415.0" "266.1" "" "" "" "" "" "" "" "" "" "" "221.5" "226.1" "237.2" "175.9" "219.5" "231.3" "252.7" "234.3" "232.8" "266.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2495561624923528868" "False" "High" "IsMasterProtein" "Q10567" "AP-1 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP1B1 PE=1 SV=3" "0.000" "False" "23.435" "5" "5" "9" "1" "949" "104.5" "5.06" "24.43" "5" "cell organization and biogenesis;transport;developmental processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf02883, Pf09066" "162" "ENSG00000100280" "AP1B1" "C9JRD1; F8WDL0; hsa:162; P78436; Q10567; Q20WL3; Q86X54" "" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "117262061430317364" "False" "High" "IsMasterProtein" "Q96T88" "E3 ubiquitin-protein ligase UHRF1 OS=Homo sapiens OX=9606 GN=UHRF1 PE=1 SV=1" "0.000" "False" "23.355" "12" "8" "8" "8" "793" "89.8" "7.56" "18.27" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00628, Pf02182, Pf12148" "29128" "ENSG00000276043" "UHRF1" "A0JBR2; A8K024; B2RBA9; Q2HIX7; Q8J022; Q96T88; Q9H6S6; Q9P115; Q9P1U7" "Pathways affected in adenoid cystic carcinoma; Pleural mesothelioma" "Chromatin modifications during the maternal to zygotic transition (MZT); DNA methylation" "4" "0" "1.095" "1.187" "1.407" "1.315" "1.072" "1.460" "1.268" "1.380" "3.625" "182.0" "199.3" "216.1" "256.0" "239.4" "195.1" "265.7" "230.8" "251.3" "659.8" "" "" "" "" "" "" "" "" "" "" "96.4" "110.5" "123.8" "117.9" "129.5" "108.5" "156.4" "126.0" "141.0" "659.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "551881844425109656" "False" "High" "IsMasterProtein" "Q13573" "SNW domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SNW1 PE=1 SV=1" "0.000" "False" "23.347" "12" "6" "7" "6" "536" "61.5" "9.52" "21.84" "6" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "signal transduction activity or receptor binding;other molecular function" "Pf02731" "22938" "ENSG00000100603" "SNW1" "A8K8A9; hsa:22938; Q13483; Q13573; Q32N03; Q5D0D6" "TGF-beta signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; Splicing factor NOVA regulated synaptic proteins; Notch signaling pathway" "mRNA Splicing - Major Pathway; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "16" "0" "1.054" "1.058" "1.106" "1.185" "1.088" "1.108" "1.197" "1.245" "0.730" "314.0" "330.9" "332.1" "347.4" "372.1" "341.6" "347.8" "375.9" "391.0" "229.1" "" "" "" "" "" "" "" "" "" "" "166.3" "183.5" "190.2" "160.0" "201.3" "190.0" "204.7" "205.2" "219.3" "229.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6037717816811945701" "False" "High" "IsMasterProtein" "Q5T8P6" "RNA-binding protein 26 OS=Homo sapiens OX=9606 GN=RBM26 PE=1 SV=3" "0.000" "False" "23.333" "7" "7" "9" "6" "1007" "113.5" "9.16" "22.24" "7" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf01480" "64062" "ENSG00000139746" "RBM26" "B4DZE0; hsa:64062; Q2NKM2; Q2NKQ2; Q5CZH8; Q5T8P5; Q5T8P6; Q5T8P8; Q5U5P5; Q5W0G7; Q8N3H5; Q96K92; Q96SZ3; Q9H2F8; Q9H7F9; Q9P1G7" "" "" "0" "0" "1.324" "1.085" "1.298" "1.268" "1.303" "1.371" "1.205" "1.429" "4.264" "236.0" "312.5" "256.1" "306.4" "299.3" "307.6" "323.7" "284.4" "337.2" "1006.3" "" "" "" "" "" "" "" "" "" "" "125.0" "173.2" "146.7" "141.1" "161.9" "171.1" "190.5" "155.2" "189.2" "1006.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8485182549121438413" "False" "High" "IsMasterProtein" "O14776" "Transcription elongation regulator 1 OS=Homo sapiens OX=9606 GN=TCERG1 PE=1 SV=2" "0.000" "False" "23.315" "6" "7" "8" "7" "1098" "123.8" "8.65" "21.92" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00397, Pf01846" "10915" "ENSG00000113649" "TCERG1" "hsa:10915; O14776; Q2NKN2; Q59EA1" "" "mRNA Splicing - Major Pathway" "1" "0" "1.047" "0.964" "1.043" "1.023" "1.082" "1.133" "0.476" "1.039" "6.266" "315.9" "330.7" "304.5" "329.4" "323.3" "341.8" "357.9" "150.2" "328.2" "1979.4" "" "" "" "" "" "" "" "" "" "" "167.3" "183.3" "174.4" "151.7" "174.9" "190.2" "210.7" "82.0" "184.1" "1979.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3259776130493618651" "False" "High" "IsMasterProtein" "Q6PI48" "Aspartate--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=DARS2 PE=1 SV=1" "0.000" "False" "23.297" "11" "7" "11" "7" "645" "73.5" "8.02" "30.70" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00152, Pf01336, Pf02938" "55157" "ENSG00000117593" "DARS2" "hsa:55157; Q6PI48" "" "Mitochondrial tRNA aminoacylation" "1" "0" "1.055" "1.004" "0.967" "0.981" "0.978" "0.847" "0.939" "0.930" "0.592" "932.4" "983.3" "936.0" "901.6" "914.5" "911.7" "789.8" "875.4" "866.9" "551.8" "" "" "" "" "" "" "" "" "" "" "493.7" "545.2" "536.1" "415.2" "494.8" "507.1" "464.8" "477.8" "486.3" "551.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4476528208765438767" "False" "High" "IsMasterProtein" "Q9Y5S9" "RNA-binding protein 8A OS=Homo sapiens OX=9606 GN=RBM8A PE=1 SV=1" "0.000" "False" "23.293" "32" "6" "14" "6" "174" "19.9" "5.72" "37.00" "6" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "9939" "ENSG00000265241" "RBM8A" "B3KQI9; hsa:9939; Q6FHD1; Q6IQ40; Q9GZX8; Q9NZI4; Q9Y5S9" "" "mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "6" "0" "0.932" "1.043" "1.032" "0.982" "0.922" "0.958" "1.041" "1.077" "0.944" "856.7" "798.6" "893.1" "883.8" "841.2" "790.1" "820.6" "891.4" "922.4" "809.1" "" "" "" "" "" "" "" "" "" "" "453.6" "442.8" "511.5" "407.0" "455.1" "439.5" "482.9" "486.6" "517.4" "809.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3263618484320997085" "False" "High" "IsMasterProtein" "Q9H098" "Protein FAM107B OS=Homo sapiens OX=9606 GN=FAM107B PE=1 SV=1" "0.000" "False" "23.277" "36" "5" "12" "4" "131" "15.5" "8.29" "34.23" "5" "" "" "" "Pf06625" "83641" "ENSG00000065809" "FAM107B" "A8K1P4; D3DRT2; hsa:83641; Q5T9K7; Q5T9K8; Q6ZSI4; Q9H098" "" "" "0" "0" "0.868" "0.938" "1.009" "0.919" "0.934" "0.963" "0.960" "0.892" "0.450" "593.4" "514.8" "556.3" "598.7" "545.1" "554.4" "571.5" "569.6" "529.0" "266.8" "" "" "" "" "" "" "" "" "" "" "314.2" "285.4" "318.6" "275.7" "294.9" "308.4" "336.4" "310.9" "296.8" "266.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8315542899134672596" "False" "High" "IsMasterProtein" "O94804" "Serine/threonine-protein kinase 10 OS=Homo sapiens OX=9606 GN=STK10 PE=1 SV=1" "0.000" "False" "23.202" "8" "8" "9" "8" "968" "112.1" "6.95" "21.07" "8" "cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12474" "6793" "ENSG00000072786" "STK10" "A6ND35; B2R8F5; B3KMY1; hsa:6793; O94804; Q6NSK0; Q9UIW4" "" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Neutrophil degranulation" "4" "0" "1.414" "0.978" "1.339" "1.262" "1.243" "1.518" "0.957" "1.553" "6.047" "203.5" "287.8" "198.9" "272.4" "256.8" "252.8" "309.0" "194.7" "316.1" "1230.5" "" "" "" "" "" "" "" "" "" "" "107.7" "159.5" "113.9" "125.4" "138.9" "140.6" "181.8" "106.3" "177.3" "1230.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2819385337701029723" "False" "High" "IsMasterProtein" "Q9UHB9" "Signal recognition particle subunit SRP68 OS=Homo sapiens OX=9606 GN=SRP68 PE=1 SV=2" "0.000" "False" "23.156" "11" "5" "6" "5" "627" "70.7" "8.56" "13.33" "5" "other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf16969" "6730" "ENSG00000167881" "SRP68" "B3KUU5; B3KWY7; G3V1U4; hsa:6730; Q8NCJ4; Q8WUK2; Q9UHB9" "" "SRP-dependent cotranslational protein targeting to membrane" "1" "0" "0.993" "0.976" "1.225" "1.010" "1.039" "0.973" "0.848" "0.868" "1.940" "234.4" "232.7" "228.7" "287.0" "236.7" "243.5" "228.1" "198.7" "203.5" "454.5" "" "" "" "" "" "" "" "" "" "" "124.1" "129.0" "131.0" "132.2" "128.1" "135.5" "134.2" "108.4" "114.1" "454.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4427751732173954290" "False" "High" "IsMasterProtein" "Q99700" "Ataxin-2 OS=Homo sapiens OX=9606 GN=ATXN2 PE=1 SV=2" "0.000" "False" "23.155" "6" "9" "12" "8" "1313" "140.2" "9.57" "32.06" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity" "Pf06741, Pf07145, Pf14438" "6311" "ENSG00000204842" "ATXN2" "A6NLD4; hsa:6311; Q24JQ7; Q6ZQZ7; Q99493; Q99700" "Parkinson's disease pathway; EGF/EGFR signaling pathway" "" "2" "0" "0.986" "0.990" "0.972" "1.025" "1.021" "0.983" "1.011" "1.043" "0.948" "1112.7" "1097.6" "1101.6" "1081.2" "1140.6" "1135.9" "1094.1" "1125.1" "1160.9" "1055.3" "" "" "" "" "" "" "" "" "" "" "589.2" "608.5" "630.9" "498.0" "617.1" "631.8" "643.9" "614.2" "651.2" "1055.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3137341147702067960" "False" "High" "IsMasterProtein" "P26440" "Isovaleryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=IVD PE=1 SV=2" "0.000" "False" "23.143" "13" "6" "11" "6" "426" "46.6" "8.05" "28.93" "6" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00441, Pf02770, Pf02771" "3712" "ENSG00000128928" "IVD" "B2RCV5; B3KVI7; hsa:3712; J3KR54; P26440; Q53XZ9; Q96AF6" "Valproic acid pathway" "Branched-chain amino acid catabolism" "2" "0" "0.940" "0.900" "0.872" "0.898" "0.934" "0.878" "0.830" "0.840" "0.527" "1055.1" "991.4" "949.8" "919.9" "947.2" "985.8" "926.6" "875.3" "886.4" "556.0" "" "" "" "" "" "" "" "" "" "" "558.7" "549.7" "543.9" "423.6" "512.5" "548.4" "545.3" "477.8" "497.2" "556.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8545908257350266971" "False" "High" "IsMasterProtein" "O15144" "Actin-related protein 2/3 complex subunit 2 OS=Homo sapiens OX=9606 GN=ARPC2 PE=1 SV=1" "0.000" "False" "23.125" "19" "6" "8" "6" "300" "34.3" "7.36" "22.99" "6" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf04045" "10109" "ENSG00000163466" "ARPC2" "hsa:10109; O15144; Q92801; Q9P1D4" "Pathogenic Escherichia coli infection" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "6" "0" "0.924" "1.048" "0.964" "0.867" "0.859" "0.701" "0.975" "0.845" "0.539" "835.4" "771.6" "875.2" "805.3" "724.5" "717.8" "585.9" "814.9" "705.9" "450.3" "" "" "" "" "" "" "" "" "" "" "442.3" "427.8" "501.2" "370.9" "392.0" "399.3" "344.8" "444.8" "396.0" "450.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6020211284576112703" "False" "High" "IsMasterProtein" "Q86UY8" "5'-nucleotidase domain-containing protein 3 OS=Homo sapiens OX=9606 GN=NT5DC3 PE=1 SV=1" "0.000" "False" "23.089" "10" "6" "8" "6" "548" "63.4" "8.31" "23.70" "6" "" "cytosol;other cell component" "other molecular function" "Pf05761" "51559" "ENSG00000111696" "NT5DC3" "hsa:51559; Q86UY8; Q9NUM7; Q9P2T2; Q9P2T3" "" "" "0" "0" "1.019" "0.942" "0.895" "1.009" "1.014" "0.971" "1.000" "0.985" "0.650" "963.8" "981.8" "908.0" "862.4" "972.9" "977.7" "935.7" "964.2" "949.1" "626.3" "" "" "" "" "" "" "" "" "" "" "510.3" "544.3" "520.0" "397.2" "526.4" "543.8" "550.7" "526.3" "532.4" "626.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7181785604482644820" "False" "High" "IsMasterProtein" "Q9NR50" "Translation initiation factor eIF2B subunit gamma OS=Homo sapiens OX=9606 GN=EIF2B3 PE=1 SV=1" "0.000" "False" "23.083" "16" "6" "6" "6" "452" "50.2" "6.47" "18.54" "6" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00483" "8891" "ENSG00000070785" "EIF2B3" "B2RBH8; D3DPZ2; hsa:8891; Q5QP89; Q5QP90; Q8NDB5; Q8WV57; Q9H850; Q9NR50" "Translation factors; Primary ovarian insufficiency" "Recycling of eIF2:GDP" "3" "0" "0.935" "0.942" "0.967" "0.941" "0.928" "0.867" "0.785" "0.817" "0.901" "529.3" "495.0" "498.8" "511.7" "497.9" "491.1" "458.9" "415.3" "432.3" "476.9" "" "" "" "" "" "" "" "" "" "" "280.3" "274.4" "285.6" "235.7" "269.4" "273.2" "270.1" "226.7" "242.5" "476.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3818907558764607522" "False" "High" "IsMasterProtein" "Q8IWD4" "Coiled-coil domain-containing protein 117 OS=Homo sapiens OX=9606 GN=CCDC117 PE=1 SV=1" "0.000" "False" "23.039" "22" "6" "7" "6" "279" "30.5" "5.07" "20.91" "6" "other biological processes" "cytoskeleton;nucleus;other cell component" "" "Pf15810" "150275" "ENSG00000159873" "CCDC117" "A8K0F1; B7Z2V1; B7Z860; hsa:150275; Q6ICA7; Q8IWD4; Q8N278" "" "" "0" "0" "0.910" "0.997" "0.910" "0.980" "0.916" "0.916" "0.954" "0.836" "0.577" "385.4" "350.9" "384.2" "350.8" "377.7" "353.1" "353.2" "367.8" "322.2" "222.6" "" "" "" "" "" "" "" "" "" "" "204.1" "194.5" "220.0" "161.5" "204.3" "196.4" "207.9" "200.8" "180.7" "222.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4234558439794556747" "False" "High" "IsMasterProtein" "Q8N6H7" "ADP-ribosylation factor GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=ARFGAP2 PE=1 SV=1" "0.000" "False" "23.038" "11" "6" "7" "6" "521" "56.7" "7.99" "17.62" "6" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf01412" "84364" "ENSG00000149182" "ARFGAP2" "B4DX29; B7Z9M7; D3DQQ9; hsa:84364; Q3LIF2; Q8N3I1; Q8N6H7; Q96SX7" "IL-18 signaling pathway; 5q35 copy number variation" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; CDC42 GTPase cycle" "5" "0" "1.029" "1.011" "0.996" "1.001" "1.008" "1.051" "0.933" "1.165" "3.309" "404.8" "416.4" "409.1" "403.2" "405.0" "408.0" "425.4" "377.6" "471.5" "1339.4" "" "" "" "" "" "" "" "" "" "" "214.3" "230.9" "234.3" "185.7" "219.1" "227.0" "250.4" "206.1" "264.5" "1339.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7873771796286241695" "False" "High" "IsMasterProtein" "A6NHL2" "Tubulin alpha chain-like 3 OS=Homo sapiens OX=9606 GN=TUBAL3 PE=1 SV=2" "0.000" "False" "22.997" "6" "2" "11" "1" "446" "49.9" "6.05" "38.87" "2" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "79861" "ENSG00000178462" "TUBAL3" "A6NHL2; B4DKL2; hsa:79861; Q4QQJ5; Q9H6Z0" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; Cilium Assembly; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling" "32" "0" "1.121" "0.986" "0.879" "0.757" "0.939" "0.811" "0.810" "0.841" "1.043" "180.0" "201.8" "177.5" "158.3" "136.2" "169.1" "145.9" "145.9" "151.5" "187.8" "" "" "" "" "" "" "" "" "" "" "95.3" "111.9" "101.6" "72.9" "73.7" "94.0" "85.9" "79.6" "85.0" "187.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6467566476375476721" "False" "High" "IsMasterProtein" "Q03154" "Aminoacylase-1 OS=Homo sapiens OX=9606 GN=ACY1 PE=1 SV=1" "0.000" "False" "22.964" "18" "7" "8" "7" "408" "45.9" "6.18" "20.17" "7" "other metabolic processes" "non-structural extracellular;cytosol" "other molecular function" "Pf01546, Pf07687" "95" "ENSG00000243989" "ACY1" "C9J6I6; C9J9D8; C9JWD4; hsa:95; Q03154" "Thyroxine (thyroid hormone) production" "Aflatoxin activation and detoxification; Paracetamol ADME; Defective ACY1 causes encephalopathy" "4" "0" "0.962" "0.997" "0.960" "0.984" "0.975" "1.077" "0.958" "0.876" "0.600" "780.5" "750.5" "777.9" "749.4" "767.9" "760.9" "841.0" "747.6" "683.4" "468.0" "" "" "" "" "" "" "" "" "" "" "413.3" "416.1" "445.5" "345.1" "415.5" "423.2" "495.0" "408.1" "383.4" "468.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "291264612704325176" "False" "High" "IsMasterProtein" "Q13685" "Angio-associated migratory cell protein OS=Homo sapiens OX=9606 GN=AAMP PE=1 SV=2" "0.000" "False" "22.962" "11" "4" "4" "4" "434" "46.7" "4.42" "15.15" "4" "developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00400" "14" "ENSG00000127837" "AAMP" "hsa:14; Q13685; Q8WUJ9; Q96H92" "Nucleotide-binding oligomerization domain (NOD) pathway" "Thromboxane signalling through TP receptor; Signaling by EGFR; NOD1/2 Signaling Pathway; Signaling by VEGF" "5" "0" "1.040" "0.998" "1.045" "1.090" "1.142" "1.079" "1.016" "1.062" "0.792" "512.6" "533.3" "511.5" "535.6" "558.7" "585.5" "553.1" "520.7" "544.5" "405.8" "" "" "" "" "" "" "" "" "" "" "271.4" "295.7" "293.0" "246.7" "302.3" "325.7" "325.5" "284.2" "305.4" "405.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2236542177406705002" "False" "High" "IsMasterProtein" "P52597" "Heterogeneous nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=HNRNPF PE=1 SV=3" "0.000" "False" "22.948" "17" "6" "11" "5" "415" "45.6" "5.58" "31.32" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf08080" "3185" "ENSG00000169813" "HNRNPF" "B3KM84; hsa:3185; P52597; Q5T0N2; Q96AU2" "MECP2 and associated Rett syndrome" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "5" "1" "0.997" "0.988" "1.013" "1.000" "1.039" "1.038" "0.719" "1.030" "4.129" "373.5" "372.3" "369.1" "378.2" "373.5" "388.1" "387.6" "268.6" "384.6" "1542.3" "" "" "" "" "" "" "" "" "" "" "197.8" "206.4" "211.4" "174.2" "202.1" "215.9" "228.1" "146.6" "215.7" "1542.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1068600970013118283" "False" "High" "IsMasterProtein" "Q99584" "Protein S100-A13 OS=Homo sapiens OX=9606 GN=S100A13 PE=1 SV=1" "0.000" "False" "22.936" "48" "5" "10" "5" "98" "11.5" "6.16" "31.84" "5" "transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01023" "6284" "ENSG00000189171" "S100A13" "hsa:6284; Q52PI9; Q6FGF8; Q99584" "" "" "0" "0" "0.958" "1.091" "1.015" "1.025" "0.959" "0.999" "1.066" "1.194" "0.656" "807.7" "773.8" "880.9" "820.1" "827.9" "774.9" "806.9" "860.7" "964.0" "529.6" "" "" "" "" "" "" "" "" "" "" "427.7" "429.0" "504.5" "377.7" "448.0" "431.0" "474.9" "469.8" "540.8" "529.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8697682766688933342" "False" "High" "IsMasterProtein" "Q9GZZ1" "N-alpha-acetyltransferase 50 OS=Homo sapiens OX=9606 GN=NAA50 PE=1 SV=1" "0.000" "False" "22.930" "30" "6" "9" "6" "169" "19.4" "8.81" "23.79" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "80218" "ENSG00000121579" "NAA50" "D3DN74; hsa:80218; Q68DQ1; Q9GZZ1" "Metapathway biotransformation Phase I and II" "" "1" "0" "1.003" "0.985" "1.027" "0.937" "0.981" "0.901" "0.929" "0.948" "0.838" "990.1" "993.3" "975.7" "1017.3" "928.0" "971.0" "892.4" "919.8" "938.8" "830.0" "" "" "" "" "" "" "" "" "" "" "524.3" "550.7" "558.8" "468.5" "502.1" "540.1" "525.2" "502.1" "526.7" "830.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3740771680866674362" "False" "High" "IsMasterProtein" "P62993" "Growth factor receptor-bound protein 2 OS=Homo sapiens OX=9606 GN=GRB2 PE=1 SV=1" "0.000" "False" "22.922" "27" "6" "9" "6" "217" "25.2" "6.32" "27.58" "6" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018" "2885" "ENSG00000177885" "GRB2" "hsa:2885; P29354; P62993; Q14450; Q63057; Q63059" "IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; IL-9 signaling pathway; Pilocytic astrocytoma; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; miRNA regulation of prostate cancer signaling pathways; p38 MAPK signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; Thermogenesis; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; 7q11.23 copy number variation syndrome; 16p11.2 distal deletion syndrome; Modulators of TCR signaling and T cell activation; Kallmann syndrome; Pleural mesothelioma; Congenital generalized lipodystrophy; GDNF signaling; 2q13 copy number variation syndrome; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; 5q35 copy number variation; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "Signaling by ALK fusions and activated point mutants; Signaling by CSF3 (G-CSF); Signaling by FLT3 ITD and TKD mutants; STAT5 activation downstream of FLT3 ITD mutants; Interleukin-15 signaling" "73" "0" "0.952" "0.992" "1.001" "1.035" "0.983" "1.014" "1.025" "0.958" "0.724" "1233.5" "1174.3" "1223.1" "1235.1" "1276.5" "1212.6" "1251.3" "1264.3" "1181.4" "892.6" "" "" "" "" "" "" "" "" "" "" "653.2" "651.1" "700.5" "568.8" "690.6" "674.5" "736.4" "690.1" "662.8" "892.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6459362278607736604" "False" "High" "IsMasterProtein" "Q9HB07" "MYG1 exonuclease OS=Homo sapiens OX=9606 GN=MYG1 PE=1 SV=4" "0.000" "False" "22.906" "14" "4" "6" "4" "376" "42.5" "6.84" "16.90" "4" "other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf03690" "60314" "ENSG00000139637; ENSG00000291835" "MYG1" "hsa:60314; Q86UA3; Q9HB07" "" "" "0" "0" "1.011" "0.966" "1.092" "1.022" "1.103" "1.167" "1.048" "0.987" "0.931" "319.1" "322.5" "308.1" "348.4" "326.1" "351.9" "372.3" "334.3" "315.0" "297.1" "" "" "" "" "" "" "" "" "" "" "169.0" "178.8" "176.5" "160.5" "176.5" "195.7" "219.1" "182.5" "176.7" "297.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2260332764015544813" "False" "High" "IsMasterProtein" "Q9BTW9" "Tubulin-specific chaperone D OS=Homo sapiens OX=9606 GN=TBCD PE=1 SV=2" "0.000" "False" "22.896" "4" "5" "7" "5" "1192" "132.5" "6.19" "23.01" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf12612" "6904" "ENSG00000141556" "TBCD" "hsa:6904; O95458; Q7L8K1; Q8IXP6; Q8NAX0; Q8WYH4; Q96E74; Q9BTW9; Q9UF82; Q9UG46; Q9Y2J3" "" "Post-chaperonin tubulin folding pathway" "1" "0" "1.071" "1.038" "1.147" "1.150" "1.124" "1.076" "0.978" "1.068" "1.659" "664.3" "711.6" "689.6" "761.6" "763.7" "746.4" "714.8" "649.5" "709.5" "1101.7" "" "" "" "" "" "" "" "" "" "" "351.7" "394.5" "394.9" "350.7" "413.2" "415.2" "420.7" "354.5" "398.0" "1101.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6201262043542307507" "False" "High" "IsMasterProtein" "P34896" "Serine hydroxymethyltransferase, cytosolic OS=Homo sapiens OX=9606 GN=SHMT1 PE=1 SV=1" "0.000" "False" "22.888" "15" "6" "6" "5" "483" "53.0" "7.71" "16.61" "6" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00464" "6470" "ENSG00000176974; ENSG00000284320" "SHMT1" "B4DPM9; D3DXD0; hsa:6470; P34896; Q96HY0; Q9UMD1; Q9UMD2" "Glycine metabolism; Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Male infertility; Neuroinflammation and glutamatergic signaling; Spina bifida; Metabolic Epileptic Disorders; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Metabolism of folate and pterines; Carnitine synthesis" "13" "0" "0.998" "1.034" "0.855" "1.025" "1.023" "0.940" "0.907" "0.946" "0.745" "515.2" "514.2" "532.8" "440.3" "528.1" "527.1" "484.4" "467.4" "487.6" "383.7" "" "" "" "" "" "" "" "" "" "" "272.8" "285.1" "305.1" "202.8" "285.7" "293.2" "285.1" "255.1" "273.5" "383.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9091705123101461009" "False" "High" "IsMasterProtein" "P99999" "Cytochrome c OS=Homo sapiens OX=9606 GN=CYCS PE=1 SV=2" "0.000" "False" "22.869" "45" "5" "9" "5" "105" "11.7" "9.57" "18.56" "5" "other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus" "other molecular function" "Pf00034" "54205" "ENSG00000172115" "CYCS" "A4D166; B2R4I1; hsa:54205; P00001; P99999; Q6NUR2; Q6NX69; Q96BV4" "miRNA regulation of DNA damage response; Apoptosis modulation and signaling; Alzheimer's disease and miRNA effects; AGE/RAGE pathway; Parkinson's disease pathway; Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling; Oxidative damage response; NO/cGMP/PKG mediated neuroprotection; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Pleural mesothelioma; Complement system in neuronal development and plasticity; Alzheimer's disease; DNA damage response" "Respiratory electron transport; Detoxification of Reactive Oxygen Species; Transcriptional activation of mitochondrial biogenesis; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Release of apoptotic factors from the mitochondria; Pyroptosis" "36" "0" "0.947" "1.009" "0.853" "1.001" "1.019" "0.954" "1.059" "1.034" "0.401" "744.1" "704.7" "751.1" "634.9" "744.5" "758.5" "709.6" "788.1" "769.2" "298.5" "" "" "" "" "" "" "" "" "" "" "394.0" "390.7" "430.2" "292.4" "402.8" "421.9" "417.6" "430.2" "431.5" "298.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6816817128509432528" "False" "High" "IsMasterProtein" "P10155" "RNA-binding protein RO60 OS=Homo sapiens OX=9606 GN=RO60 PE=1 SV=2" "0.000" "False" "22.867" "12" "8" "12" "8" "538" "60.6" "8.03" "33.92" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05731" "6738" "ENSG00000116747" "RO60" "B2RBB9; hsa:6738; P10155; Q5LJ98; Q5LJ99; Q5LJA0; Q86WL3; Q86WL4; Q92787; Q9H1W6" "" "" "0" "0" "0.908" "0.972" "0.915" "0.943" "0.944" "0.978" "0.902" "0.956" "0.621" "2206.8" "2004.9" "2144.5" "2019.7" "2081.6" "2083.3" "2158.2" "1989.5" "2108.7" "1370.7" "" "" "" "" "" "" "" "" "" "" "1168.5" "1111.6" "1228.2" "930.1" "1126.3" "1158.8" "1270.2" "1086.0" "1182.9" "1370.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7312941423538826307" "False" "High" "IsMasterProtein" "P31350" "Ribonucleoside-diphosphate reductase subunit M2 OS=Homo sapiens OX=9606 GN=RRM2 PE=1 SV=1" "0.000" "False" "22.841" "19" "7" "10" "6" "389" "44.8" "5.38" "30.00" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00268" "6241" "ENSG00000171848" "RRM2" "B2R9B5; hsa:6241; J3KP43; P31350; Q5WRU7" "Fluoropyrimidine activity; Retinoblastoma gene in cancer; Hepatitis C and hepatocellular carcinoma; Pyrimidine metabolism; Orexin receptor pathway" "Transcriptional Regulation by E2F6; Interconversion of nucleotide di- and triphosphates; G1/S-Specific Transcription" "8" "1" "0.997" "0.919" "1.025" "1.044" "1.021" "1.006" "0.991" "0.963" "0.654" "1008.0" "1005.0" "926.8" "1033.4" "1052.3" "1029.0" "1014.2" "999.1" "971.2" "658.9" "" "" "" "" "" "" "" "" "" "" "533.7" "557.2" "530.8" "475.9" "569.4" "572.3" "596.9" "545.3" "544.8" "658.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2645630736488314632" "False" "High" "IsMasterProtein" "P04080" "Cystatin-B OS=Homo sapiens OX=9606 GN=CSTB PE=1 SV=2" "0.000" "False" "22.801" "34" "3" "7" "3" "98" "11.1" "7.56" "24.95" "3" "other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00031" "1476" "ENSG00000160213" "CSTB" "hsa:1476; P04080" "" "Neutrophil degranulation" "1" "0" "0.948" "1.187" "1.084" "1.051" "1.065" "1.046" "1.160" "1.409" "0.532" "746.3" "707.5" "885.9" "809.1" "784.1" "794.9" "780.6" "865.5" "1051.9" "397.3" "" "" "" "" "" "" "" "" "" "" "395.2" "392.3" "507.4" "372.6" "424.2" "442.1" "459.4" "472.4" "590.1" "397.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6048249212605468111" "False" "High" "IsMasterProtein" "P30876" "DNA-directed RNA polymerase II subunit RPB2 OS=Homo sapiens OX=9606 GN=POLR2B PE=1 SV=1" "0.000" "False" "22.785" "6" "7" "7" "7" "1174" "133.8" "6.87" "18.20" "7" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf04566, Pf04567" "5431" "ENSG00000047315" "POLR2B" "A8K1A8; hsa:5431; P30876; Q8IZ61" "Pyrimidine metabolism; Eukaryotic transcription initiation" "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "43" "0" "1.000" "0.968" "0.951" "0.974" "0.941" "1.015" "0.875" "0.946" "1.347" "1642.5" "1642.4" "1590.2" "1561.8" "1599.7" "1545.2" "1666.5" "1437.3" "1553.6" "2213.2" "" "" "" "" "" "" "" "" "" "" "869.7" "910.6" "910.7" "719.3" "865.5" "859.5" "980.8" "784.6" "871.5" "2213.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7953357218888963531" "False" "High" "IsMasterProtein" "Q3KQU3" "MAP7 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MAP7D1 PE=1 SV=1" "0.000" "False" "22.774" "9" "8" "10" "8" "841" "92.8" "10.11" "24.14" "8" "cell organization and biogenesis" "cytoskeleton;other cell component" "" "Pf05672" "55700" "ENSG00000116871" "MAP7D1" "D3DPS4; hsa:55700; Q3KQU3; Q7L8J5; Q8N905; Q8TAK0; Q9HBQ2; Q9NW29; Q9ULN3" "" "" "0" "0" "1.042" "1.003" "0.966" "0.984" "0.961" "0.886" "0.877" "0.945" "0.922" "1116.5" "1163.3" "1119.6" "1078.8" "1098.8" "1072.7" "989.5" "979.7" "1055.5" "1029.3" "" "" "" "" "" "" "" "" "" "" "591.2" "645.0" "641.2" "496.8" "594.5" "596.7" "582.4" "534.7" "592.1" "1029.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4783590985173723979" "False" "High" "IsMasterProtein" "Q96CN7" "Isochorismatase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ISOC1 PE=1 SV=3" "0.000" "False" "22.769" "16" "5" "8" "5" "298" "32.2" "7.39" "19.01" "5" "" "other cytoplasmic organelle;other cell component" "" "Pf00857" "51015" "ENSG00000066583" "ISOC1" "hsa:51015; Q7Z770; Q96CN7" "" "" "0" "0" "1.048" "1.009" "1.142" "0.988" "0.985" "1.026" "1.069" "0.938" "0.527" "452.1" "473.6" "456.3" "516.2" "446.9" "445.5" "464.0" "483.1" "424.2" "238.5" "" "" "" "" "" "" "" "" "" "" "239.4" "262.6" "261.3" "237.7" "241.8" "247.8" "273.1" "263.7" "237.9" "238.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7462216625703255168" "False" "High" "IsMasterProtein" "O43847" "Nardilysin OS=Homo sapiens OX=9606 GN=NRDC PE=1 SV=3" "0.000" "False" "22.754" "5" "6" "8" "6" "1151" "131.6" "4.98" "20.56" "6" "protein metabolism;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00675, Pf05193, Pf16187" "4898" "ENSG00000078618" "NRDC" "A6NI41; hsa:4898; O15241; O15242; O43847; Q5VUL0; Q96HB2; Q9NU57" "" "" "0" "0" "1.114" "1.159" "1.225" "1.305" "1.332" "1.239" "1.214" "1.488" "1.832" "297.0" "330.9" "344.2" "363.8" "387.6" "395.6" "367.9" "360.5" "442.0" "544.1" "" "" "" "" "" "" "" "" "" "" "157.3" "183.4" "197.1" "167.5" "209.7" "220.0" "216.5" "196.8" "247.9" "544.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6101901840121098087" "False" "High" "IsMasterProtein" "P52788" "Spermine synthase OS=Homo sapiens OX=9606 GN=SMS PE=1 SV=2" "0.000" "False" "22.748" "16" "7" "12" "7" "366" "41.2" "5.02" "32.59" "7" "other metabolic processes" "cytosol" "other molecular function" "Pf01564, Pf17284, Pf17950" "6611" "ENSG00000102172" "SMS" "A6NHA7; A6NI34; B2R9M0; hsa:6611; O00544; P52788; Q9UQS1" "Methionine de novo and salvage pathway; Amino acid metabolism" "Metabolism of polyamines" "3" "0" "1.087" "1.031" "1.158" "0.990" "1.073" "1.020" "1.069" "0.928" "0.640" "993.7" "1079.7" "1024.3" "1150.5" "983.8" "1065.8" "1013.2" "1062.6" "922.0" "636.4" "" "" "" "" "" "" "" "" "" "" "526.2" "598.6" "586.6" "529.9" "532.3" "592.8" "596.3" "580.0" "517.2" "636.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3039044237151127382" "False" "High" "IsMasterProtein" "P61163" "Alpha-centractin OS=Homo sapiens OX=9606 GN=ACTR1A PE=1 SV=1" "0.000" "False" "22.726" "15" "5" "5" "5" "376" "42.6" "6.64" "18.63" "5" "transport" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00022" "10121" "ENSG00000138107" "ACTR1A" "B2R6B0; hsa:10121; P42024; P61163" "HDAC6 interactions in the central nervous system" "COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "12" "0" "1.030" "0.992" "0.992" "1.099" "1.164" "1.026" "1.106" "1.086" "0.753" "516.8" "532.1" "512.5" "512.5" "568.0" "601.7" "530.0" "571.7" "561.1" "389.2" "" "" "" "" "" "" "" "" "" "" "273.6" "295.0" "293.5" "236.0" "307.3" "334.7" "311.9" "312.1" "314.8" "389.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7915311945115274700" "False" "High" "IsMasterProtein" "O15212" "Prefoldin subunit 6 OS=Homo sapiens OX=9606 GN=PFDN6 PE=1 SV=1" "0.000" "False" "22.721" "43" "6" "10" "6" "129" "14.6" "8.88" "29.34" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf01920" "10471" "ENSG00000204220; ENSG00000206283; ENSG00000224782; ENSG00000235692; ENSG00000237335" "PFDN6" "hsa:10471; O15212" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "1.002" "1.046" "0.995" "0.859" "0.910" "0.961" "1.028" "1.033" "0.561" "958.6" "960.3" "1002.6" "954.2" "823.7" "872.4" "920.8" "985.6" "990.6" "538.1" "" "" "" "" "" "" "" "" "" "" "507.6" "532.4" "574.2" "439.4" "445.7" "485.3" "541.9" "538.0" "555.7" "538.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4023730213020721894" "False" "High" "IsMasterProtein" "Q9NVX2" "Notchless protein homolog 1 OS=Homo sapiens OX=9606 GN=NLE1 PE=1 SV=4" "0.000" "False" "22.700" "9" "4" "5" "4" "485" "53.3" "7.34" "18.55" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "nucleus" "" "Pf00400, Pf08154" "54475" "ENSG00000073536" "NLE1" "hsa:54475; O60868; Q59GJ8; Q9BU54; Q9NVX2" "17q12 copy number variation syndrome" "" "1" "0" "0.948" "0.944" "1.075" "1.065" "1.100" "1.296" "1.156" "1.067" "0.814" "512.8" "486.1" "484.2" "551.2" "546.1" "564.3" "664.4" "592.9" "547.1" "417.5" "" "" "" "" "" "" "" "" "" "" "271.5" "269.5" "277.3" "253.8" "295.4" "313.9" "391.0" "323.7" "306.9" "417.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2449426517635308859" "False" "High" "IsMasterProtein" "Q9H6F5" "Coiled-coil domain-containing protein 86 OS=Homo sapiens OX=9606 GN=CCDC86 PE=1 SV=1" "0.000" "False" "22.697" "14" "4" "7" "4" "360" "40.2" "10.33" "13.92" "4" "" "nucleus;other cell component" "" "Pf03879" "79080" "ENSG00000110104" "CCDC86" "B4DY99; hsa:79080; Q9H6F5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2222820814571899525" "False" "High" "IsMasterProtein" "Q9UJ70" "N-acetyl-D-glucosamine kinase OS=Homo sapiens OX=9606 GN=NAGK PE=1 SV=4" "0.000" "False" "22.693" "18" "5" "7" "5" "344" "37.4" "6.24" "16.05" "5" "other metabolic processes;stress response;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf01869" "55577" "ENSG00000124357" "NAGK" "B4DLZ5; hsa:55577; Q53HD5; Q6IA84; Q9BS29; Q9BVP0; Q9NV37; Q9UJ70" "" "Synthesis of UDP-N-acetyl-glucosamine" "1" "0" "0.843" "0.949" "0.926" "0.894" "0.932" "0.780" "0.896" "0.800" "0.642" "369.8" "311.9" "351.0" "342.6" "330.4" "344.6" "288.5" "331.5" "296.0" "237.5" "" "" "" "" "" "" "" "" "" "" "195.8" "172.9" "201.0" "157.8" "178.8" "191.7" "169.8" "180.9" "166.0" "237.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3292354779633865334" "False" "High" "IsMasterProtein" "A5YKK6" "CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=2" "0.000" "False" "22.670" "3" "8" "9" "8" "2376" "266.8" "7.11" "20.86" "8" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04054, Pf12842, Pf16415, Pf16417, Pf16418" "23019" "ENSG00000125107" "CNOT1" "A5YKK6; hsa:23019; Q68DX7; Q7Z3K2; Q8IWB8; Q8TB53; Q9BVZ6; Q9UFR8; Q9UI27; Q9Y2L0" "Ciliary landscape" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "4" "0" "1.025" "0.929" "1.091" "1.028" "1.087" "1.121" "0.899" "1.082" "3.248" "682.9" "699.7" "634.4" "745.0" "702.0" "742.1" "765.7" "613.6" "738.8" "2217.9" "" "" "" "" "" "" "" "" "" "" "361.6" "387.9" "363.3" "343.1" "379.8" "412.8" "450.6" "335.0" "414.4" "2217.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5207555211981118816" "False" "High" "IsMasterProtein" "Q08J23" "RNA cytosine C(5)-methyltransferase NSUN2 OS=Homo sapiens OX=9606 GN=NSUN2 PE=1 SV=2" "0.000" "False" "22.616" "9" "6" "8" "6" "767" "86.4" "6.77" "22.10" "6" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01189" "54888" "ENSG00000037474" "NSUN2" "A8K529; B2RNR4; B3KP09; B4DQW2; G3V1R4; hsa:54888; Q08J23; Q9BVN4; Q9H858; Q9NXD9" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.153" "0.985" "1.150" "1.042" "1.094" "1.035" "0.545" "0.992" "6.083" "203.9" "235.2" "200.7" "234.5" "212.5" "223.0" "211.1" "111.2" "202.3" "1240.4" "" "" "" "" "" "" "" "" "" "" "108.0" "130.4" "115.0" "108.0" "115.0" "124.0" "124.3" "60.7" "113.5" "1240.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7375658416039081200" "False" "High" "IsMasterProtein" "Q9GZU8" "PSME3-interacting protein OS=Homo sapiens OX=9606 GN=PSME3IP1 PE=1 SV=1" "0.000" "False" "22.601" "29" "9" "12" "9" "254" "28.9" "5.45" "33.13" "9" "other biological processes" "nucleus;other cell component" "" "Pf10187" "80011" "ENSG00000172775" "PSME3IP1" "hsa:80011; Q9GZU8" "" "" "0" "0" "0.982" "1.046" "0.950" "0.946" "0.908" "0.902" "1.088" "0.978" "0.531" "1918.8" "1884.1" "2007.2" "1822.8" "1815.4" "1742.3" "1730.4" "2087.2" "1876.8" "1019.7" "" "" "" "" "" "" "" "" "" "" "1016.0" "1044.6" "1149.5" "839.5" "982.2" "969.2" "1018.4" "1139.3" "1052.9" "1019.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1166927996766443346" "False" "High" "IsMasterProtein" "P28482" "Mitogen-activated protein kinase 1 OS=Homo sapiens OX=9606 GN=MAPK1 PE=1 SV=3" "0.000" "False" "22.575" "21" "7" "13" "7" "360" "41.4" "6.98" "31.71" "7" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069" "5594" "ENSG00000100030" "MAPK1" "A8CZ64; hsa:5594; P28482" "IL-5 signaling pathway; Osteopontin signaling; Physiological and pathological hypertrophy of the heart; Angiogenesis; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; Heart development; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; Endothelin pathways; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; PDGF pathway; Aryl hydrocarbon receptor pathway; S1P receptor signal transduction; Ebstein-Barr virus LMP1 signaling; Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Bladder cancer; IL-3 signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; TCA cycle nutrient use and invasiveness of ovarian cancer; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; MFAP5-mediated ovarian cancer cell motility and invasiveness; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; IL6 signaling pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; ERK pathway in Huntington's disease; Toll-like receptor signaling related to MyD88; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; miRNA regulation of prostate cancer signaling pathways; Prion disease pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Neovascularization processes; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Bile acids synthesis and enterohepatic circulation ; LTF danger signal response pathway; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Regulatory circuits of the STAT3 signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Regucalcin in proximal tubule epithelial kidney cells; Kisspeptin/kisspeptin receptor system in the ovary; MAP3K1 role in promoting and blocking gonadal determination; CAMKK2 pathway; Disruption of postsynaptic signaling by CNV; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; RAS and bradykinin pathways in COVID-19; Angiotensin II receptor type 1 pathway; Kallmann syndrome; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Sphingolipid metabolism in senescence; Alzheimer's disease; Th17 cell differentiation pathway; GDNF signaling; 2q11.2 copy number variation syndrome; 2q13 copy number variation syndrome; Hippocampal synaptogenesis and neurogenesis; Comprehensive IL-17A signaling; Genetic causes of porto-sinusoidal vascular disease; Acute myeloid leukemia; Female steroid hormones in cardiomyocyte energy metabolism; Cardiomyocyte signaling pathways converging on titin; 8p23.1 copy number variation syndrome; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; Osteoarthritic chondrocyte hypertrophy; NPHP1 deletion syndrome; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; GNAQ pathways in port-wine stain; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Estrogen signaling pathway; Vitamin A and carotenoid metabolism; Toll-like receptor signaling pathway" "Recycling pathway of L1; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCGR3A-mediated phagocytosis; NPAS4 regulates expression of target genes; RHO GTPases Activate WASPs and WAVEs; Regulation of HSF1-mediated heat shock response; Signaling by BRAF and RAF1 fusions; Thrombin signalling through proteinase activated receptors (PARs); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Signaling by NODAL; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Interferon gamma signaling; Oncogene Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Growth hormone receptor signaling; Regulation of the apoptosome activity; Signal transduction by L1; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; NCAM signaling for neurite out-growth; RUNX2 regulates osteoblast differentiation; RSK activation; Estrogen-stimulated signaling through PRKCZ; Spry regulation of FGF signaling; Suppression of apoptosis; MAPK1 (ERK2) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; IFNG signaling activates MAPKs; Golgi Cisternae Pericentriolar Stack Reorganization; Signaling by Activin; Activation of the AP-1 family of transcription factors; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Signal attenuation; Gastrin-CREB signalling pathway via PKC and MAPK; ESR-mediated signaling; Negative feedback regulation of MAPK pathway; Advanced glycosylation endproduct receptor signaling; RHO GTPases Activate NADPH Oxidases; Nuclear events stimulated by ALK signaling in cancer; ERKs are inactivated; Signaling by MAP2K mutants; phospho-PLA2 pathway; Signaling by MAPK mutants" "208" "0" "0.998" "1.004" "1.033" "1.040" "1.057" "1.006" "0.997" "0.945" "0.851" "1646.2" "1643.3" "1652.1" "1701.2" "1711.7" "1739.5" "1656.2" "1641.3" "1555.4" "1401.0" "" "" "" "" "" "" "" "" "" "" "871.7" "911.1" "946.2" "783.4" "926.1" "967.6" "974.7" "895.9" "872.6" "1401.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4004494409327660908" "False" "High" "IsMasterProtein" "P07205" "Phosphoglycerate kinase 2 OS=Homo sapiens OX=9606 GN=PGK2 PE=1 SV=3" "0.000" "False" "22.532" "15" "6" "27" "2" "417" "44.8" "8.54" "59.96" "6" "other metabolic processes;other biological processes" "cytosol;cytoskeleton" "kinase activity;other molecular function" "Pf00162" "5232" "ENSG00000170950" "PGK2" "B2R6Y8; hsa:5232; P07205; Q9H107" "Cori cycle; Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Gluconeogenesis" "6" "0" "1.028" "1.039" "0.920" "1.111" "1.084" "0.950" "0.987" "1.003" "0.600" "1704.7" "1751.6" "1770.8" "1568.4" "1894.6" "1848.7" "1619.2" "1682.2" "1710.0" "1023.1" "" "" "" "" "" "" "" "" "" "" "902.6" "971.1" "1014.1" "722.3" "1025.1" "1028.3" "953.0" "918.3" "959.3" "1023.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3197858597980699967" "False" "High" "IsMasterProtein" "Q9HA64" "Ketosamine-3-kinase OS=Homo sapiens OX=9606 GN=FN3KRP PE=1 SV=2" "0.000" "False" "22.507" "20" "5" "6" "5" "309" "34.4" "7.33" "19.31" "5" "protein metabolism;other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf03881" "79672" "ENSG00000141560" "FN3KRP" "hsa:79672; Q969F4; Q9H0U7; Q9HA64" "" "Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation" "1" "0" "0.912" "0.954" "0.944" "0.996" "0.940" "1.013" "0.996" "0.937" "0.637" "821.5" "749.2" "783.6" "775.6" "818.5" "772.0" "832.6" "818.4" "769.4" "523.4" "" "" "" "" "" "" "" "" "" "" "435.0" "415.4" "448.8" "357.2" "442.9" "429.4" "490.0" "446.7" "431.6" "523.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6258947584785222358" "False" "High" "IsMasterProtein" "P62906" "Large ribosomal subunit protein uL1 OS=Homo sapiens OX=9606 GN=RPL10A PE=1 SV=2" "0.000" "False" "22.503" "29" "6" "21" "6" "217" "24.8" "9.94" "50.04" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf00687" "4736" "ENSG00000198755" "RPL10A" "B2R801; hsa:4736; P52859; P53025; P62906; Q5TZT6; Q8J013" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "1.021" "1.019" "1.103" "1.077" "1.127" "1.111" "1.100" "1.013" "0.671" "1212.5" "1238.1" "1236.2" "1337.7" "1306.4" "1366.2" "1347.7" "1334.0" "1228.5" "813.4" "" "" "" "" "" "" "" "" "" "" "642.0" "686.5" "708.0" "616.1" "706.8" "760.0" "793.1" "728.2" "689.1" "813.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1679721907195940966" "False" "High" "IsMasterProtein" "P50502" "Hsc70-interacting protein OS=Homo sapiens OX=9606 GN=ST13 PE=1 SV=2" "0.000" "False" "22.499" "17" "6" "16" "6" "369" "41.3" "5.27" "36.81" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf17830, Pf18253" "6767" "ENSG00000100380" "ST13" "hsa:6767; O14999; P50502; Q2TU77" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "1.039" "1.050" "1.053" "0.988" "1.014" "1.068" "1.042" "1.043" "1.529" "753.5" "783.1" "791.3" "793.4" "744.6" "764.2" "804.5" "785.1" "786.0" "1152.5" "" "" "" "" "" "" "" "" "" "" "399.0" "434.2" "453.2" "365.4" "402.9" "425.1" "473.5" "428.5" "440.9" "1152.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6322413842474440718" "False" "High" "IsMasterProtein" "Q96IR7" "4-hydroxyphenylpyruvate dioxygenase-like protein OS=Homo sapiens OX=9606 GN=HPDL PE=1 SV=1" "0.000" "False" "22.485" "14" "5" "6" "5" "371" "39.4" "7.03" "18.21" "5" "other metabolic processes" "mitochondrion" "other molecular function" "" "84842" "ENSG00000186603" "HPDL" "B2R9B0; hsa:84842; Q96IR7" "" "" "0" "0" "1.015" "0.987" "1.045" "1.213" "1.474" "1.486" "1.128" "1.465" "0.803" "363.8" "369.2" "359.0" "380.2" "441.3" "536.2" "540.7" "410.3" "533.0" "292.3" "" "" "" "" "" "" "" "" "" "" "192.7" "204.7" "205.6" "175.1" "238.8" "298.3" "318.2" "223.9" "299.0" "292.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9215017324203505863" "False" "High" "IsMasterProtein" "Q6Y7W6" "GRB10-interacting GYF protein 2 OS=Homo sapiens OX=9606 GN=GIGYF2 PE=1 SV=1" "0.000" "False" "22.468" "3" "4" "6" "4" "1299" "150.0" "5.54" "18.00" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02213" "26058" "ENSG00000204120" "GIGYF2" "A6H8W4; B9EG55; E9PBB0; hsa:26058; O75137; Q6Y7W6; Q7Z2Z8; Q7Z3I2; Q96HU4; Q9NV82" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.033" "0.994" "1.212" "1.166" "1.029" "1.845" "1.892" "1.848" "1.609" "277.9" "287.1" "276.3" "336.8" "324.1" "285.9" "512.8" "525.8" "513.5" "447.2" "" "" "" "" "" "" "" "" "" "" "147.2" "159.2" "158.3" "155.1" "175.3" "159.0" "301.8" "287.0" "288.1" "447.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7164252361216930989" "False" "High" "IsMasterProtein" "P27707" "Deoxycytidine kinase OS=Homo sapiens OX=9606 GN=DCK PE=1 SV=1" "0.000" "False" "22.433" "18" "5" "9" "5" "260" "30.5" "5.21" "28.67" "5" "other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf01712" "1633" "ENSG00000156136" "DCK" "B2R8V6; hsa:1633; P27707; Q5TZY7; Q6FI11" "Retinoblastoma gene in cancer; Pyrimidine metabolism" "Pyrimidine salvage; Purine salvage" "4" "0" "0.990" "1.048" "1.155" "0.980" "0.968" "0.910" "1.030" "0.918" "0.610" "494.6" "489.9" "518.5" "571.1" "484.8" "478.9" "450.2" "509.5" "453.9" "302.0" "" "" "" "" "" "" "" "" "" "" "261.9" "271.6" "296.9" "263.0" "262.3" "266.4" "264.9" "278.1" "254.6" "302.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1135638411849566769" "False" "High" "IsMasterProtein" "O76021" "Ribosomal L1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RSL1D1 PE=1 SV=3" "0.000" "False" "22.426" "12" "6" "7" "6" "490" "54.9" "10.13" "22.32" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf00687" "26156" "ENSG00000171490" "RSL1D1" "B4DJ58; D3DUG7; hsa:26156; O76021; Q2M1T7; Q6PL22; Q8IWS7; Q8WUZ1; Q9HDA9; Q9Y3Z9" "" "" "0" "0" "1.139" "0.998" "1.261" "1.061" "1.037" "1.074" "1.086" "1.186" "0.802" "904.8" "1030.3" "903.1" "1141.0" "959.6" "938.5" "971.9" "982.5" "1072.8" "725.4" "" "" "" "" "" "" "" "" "" "" "479.1" "571.2" "517.2" "525.5" "519.2" "522.1" "572.0" "536.3" "601.8" "725.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2127950675318566661" "False" "High" "IsMasterProtein" "Q9UJA5" "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 OS=Homo sapiens OX=9606 GN=TRMT6 PE=1 SV=1" "0.000" "False" "22.423" "13" "8" "9" "8" "497" "55.8" "7.55" "27.60" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf04189" "51605" "ENSG00000089195" "TRMT6" "B4DUV6; hsa:51605; Q76P92; Q9BQV5; Q9UJA5; Q9ULR7; Q9Y2Z8" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.964" "0.981" "0.954" "0.990" "1.000" "1.031" "0.962" "0.997" "0.619" "1468.9" "1415.9" "1440.7" "1401.2" "1453.9" "1468.7" "1514.4" "1412.7" "1464.3" "909.3" "" "" "" "" "" "" "" "" "" "" "777.8" "785.0" "825.1" "645.3" "786.6" "817.0" "891.3" "771.1" "821.4" "909.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-191513720103364216" "False" "High" "IsMasterProtein" "Q8TAA3" "Proteasome subunit alpha-type 8 OS=Homo sapiens OX=9606 GN=PSMA8 PE=1 SV=3" "0.000" "False" "22.408" "13" "3" "7" "1" "256" "28.5" "8.98" "20.24" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "" "Pf00227, Pf10584" "143471" "ENSG00000154611" "PSMA8" "B0YJ75; hsa:143471; Q8IVP4; Q8TA98; Q8TAA2; Q8TAA3" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; UCH proteinases; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway" "54" "0" "1.041" "0.890" "0.872" "1.049" "1.042" "1.092" "0.903" "0.958" "0.776" "194.9" "202.8" "173.4" "169.8" "204.5" "203.1" "212.8" "176.0" "186.7" "151.1" "" "" "" "" "" "" "" "" "" "" "103.2" "112.4" "99.3" "78.2" "110.6" "113.0" "125.2" "96.0" "104.7" "151.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5428916693947129614" "False" "High" "IsMasterProtein" "Q92556" "Engulfment and cell motility protein 1 OS=Homo sapiens OX=9606 GN=ELMO1 PE=1 SV=2" "0.000" "False" "22.400" "10" "8" "9" "8" "727" "83.8" "6.28" "18.41" "8" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf04727, Pf11841, Pf16457" "9844" "ENSG00000155849" "ELMO1" "A4D1X6; hsa:9844; Q29R79; Q6ZTJ0; Q92556; Q96PB0; Q9H0I1" "Chemokine signaling pathway; CCL18 signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; VEGFA-VEGFR2 Pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Nef and signal transduction" "7" "0" "0.907" "1.048" "0.993" "1.060" "1.141" "1.125" "0.602" "1.154" "7.557" "400.0" "362.8" "419.1" "397.2" "424.1" "456.2" "450.1" "240.8" "461.5" "3022.5" "" "" "" "" "" "" "" "" "" "" "211.8" "201.2" "240.0" "182.9" "229.4" "253.8" "264.9" "131.4" "258.9" "3022.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3427598645898203721" "False" "High" "IsMasterProtein" "O14828" "Secretory carrier-associated membrane protein 3 OS=Homo sapiens OX=9606 GN=SCAMP3 PE=1 SV=3" "0.000" "False" "22.388" "13" "3" "3" "3" "347" "38.3" "7.64" "13.88" "3" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04144" "10067" "ENSG00000116521; ENSG00000263290" "SCAMP3" "A9Z1W6; B1AVS6; hsa:10067; O14828; O15128; Q96FR8; Q9BPY0" "" "" "0" "0" "1.068" "0.948" "1.174" "1.041" "1.073" "1.036" "1.039" "0.987" "0.849" "125.5" "134.1" "119.0" "147.4" "130.7" "134.7" "130.1" "130.4" "123.9" "106.5" "" "" "" "" "" "" "" "" "" "" "66.5" "74.4" "68.2" "67.9" "70.7" "74.9" "76.6" "71.2" "69.5" "106.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3247337186477247949" "False" "High" "IsMasterProtein" "Q9UQR1" "Zinc finger protein 148 OS=Homo sapiens OX=9606 GN=ZNF148 PE=1 SV=2" "0.000" "False" "22.385" "9" "5" "5" "5" "794" "88.9" "6.48" "13.45" "5" "stress response;other biological processes" "ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "7707" "ENSG00000163848" "ZNF148" "D3DN27; O00389; O43591; Q58EY5; Q6PJ98; Q9UQR1" "" "" "0" "0" "0.861" "0.871" "1.076" "0.856" "0.885" "0.988" "1.005" "0.893" "0.946" "134.5" "115.9" "117.1" "144.7" "115.2" "119.0" "132.9" "135.2" "120.1" "127.3" "" "" "" "" "" "" "" "" "" "" "71.2" "64.2" "67.1" "66.7" "62.3" "66.2" "78.2" "73.8" "67.3" "127.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2463119363191037669" "False" "High" "IsMasterProtein" "Q66LE6" "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform OS=Homo sapiens OX=9606 GN=PPP2R2D PE=1 SV=1" "0.000" "False" "22.381" "7" "4" "5" "3" "453" "52.0" "6.39" "16.25" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "" "55844" "ENSG00000175470" "PPP2R2D" "A8KAK0; hsa:55844; Q5SQJ2; Q66LE6; Q9P1Y7" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "MASTL Facilitates Mitotic Progression" "3" "0" "0.971" "1.113" "1.177" "1.072" "1.199" "1.170" "1.005" "1.008" "0.785" "216.1" "209.9" "240.5" "254.5" "231.7" "259.1" "252.8" "217.2" "217.9" "169.7" "" "" "" "" "" "" "" "" "" "" "114.4" "116.4" "137.7" "117.2" "125.4" "144.1" "148.8" "118.6" "122.2" "169.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4892989875718200247" "False" "High" "IsMasterProtein" "Q9UL46" "Proteasome activator complex subunit 2 OS=Homo sapiens OX=9606 GN=PSME2 PE=1 SV=4" "0.000" "False" "22.351" "21" "5" "15" "5" "239" "27.4" "5.73" "38.30" "5" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02251, Pf02252" "5721" "ENSG00000100911; ENSG00000284889" "PSME2" "hsa:5721; Q15129; Q9UL46" "Proteasome degradation" "Assembly of the pre-replicative complex; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "61" "0" "1.136" "1.062" "0.977" "0.951" "1.118" "1.216" "1.228" "1.220" "0.723" "1558.3" "1769.8" "1655.1" "1522.6" "1482.3" "1742.8" "1894.2" "1913.2" "1900.6" "1126.4" "" "" "" "" "" "" "" "" "" "" "825.1" "981.2" "947.9" "701.2" "802.0" "969.4" "1114.8" "1044.3" "1066.2" "1126.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6495840506053035661" "False" "High" "IsMasterProtein" "Q9NRV9" "Heme-binding protein 1 OS=Homo sapiens OX=9606 GN=HEBP1 PE=1 SV=1" "0.000" "False" "22.313" "26" "4" "4" "4" "189" "21.1" "5.80" "15.58" "4" "other biological processes" "non-structural extracellular;other cell component" "other molecular function" "Pf04832" "50865" "ENSG00000013583" "HEBP1" "A8K1G2; hsa:50865; Q9NRV9; Q9Y5Z5" "" "G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands" "2" "0" "0.962" "1.057" "0.917" "0.981" "1.025" "0.926" "1.035" "1.080" "0.718" "766.6" "737.6" "810.1" "703.0" "752.1" "785.8" "709.7" "793.1" "828.0" "550.6" "" "" "" "" "" "" "" "" "" "" "405.9" "409.0" "463.9" "323.7" "406.9" "437.1" "417.7" "432.9" "464.5" "550.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5402029241356858044" "False" "High" "IsMasterProtein" "P09936" "Ubiquitin carboxyl-terminal hydrolase isozyme L1 OS=Homo sapiens OX=9606 GN=UCHL1 PE=1 SV=2" "0.000" "False" "22.301" "26" "6" "11" "6" "223" "24.8" "5.48" "32.69" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01088" "7345" "ENSG00000154277" "UCHL1" "hsa:7345; P09936; Q4W5K6; Q71UM0" "Proteasome degradation; Parkinson's disease pathway; Hepatitis C and hepatocellular carcinoma" "UCH proteinases" "4" "0" "1.119" "1.038" "1.075" "1.080" "1.100" "1.096" "1.113" "1.126" "0.774" "1846.2" "2066.6" "1917.2" "1984.0" "1994.3" "2030.2" "2023.3" "2055.0" "2078.2" "1429.1" "" "" "" "" "" "" "" "" "" "" "977.6" "1145.8" "1098.0" "913.7" "1079.0" "1129.3" "1190.8" "1121.7" "1165.8" "1429.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "439747598683617185" "False" "High" "IsMasterProtein" "Q9UI10" "Translation initiation factor eIF2B subunit delta OS=Homo sapiens OX=9606 GN=EIF2B4 PE=1 SV=2" "0.000" "False" "22.275" "11" "5" "7" "5" "523" "57.5" "9.38" "18.30" "5" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01008" "8890" "ENSG00000115211" "EIF2B4" "hsa:8890; Q53RY7; Q5BJF4; Q9BUV9; Q9UBG4; Q9UI10; Q9UIQ9; Q9UJ95" "Translation factors; Primary ovarian insufficiency" "Recycling of eIF2:GDP" "3" "0" "0.986" "0.948" "0.877" "0.966" "1.024" "0.806" "0.796" "0.817" "0.843" "855.9" "843.9" "811.3" "750.9" "826.9" "876.7" "690.0" "680.9" "699.7" "721.6" "" "" "" "" "" "" "" "" "" "" "453.2" "467.9" "464.6" "345.8" "447.4" "487.7" "406.1" "371.7" "392.5" "721.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3348063048302493190" "False" "High" "IsMasterProtein" "P50851" "Lipopolysaccharide-responsive and beige-like anchor protein OS=Homo sapiens OX=9606 GN=LRBA PE=1 SV=4" "0.000" "False" "22.261" "3" "8" "8" "8" "2863" "318.9" "5.60" "18.36" "8" "cell organization and biogenesis;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf02138, Pf06469, Pf13385, Pf14844, Pf15787, Pf20425, Pf20426" "987" "ENSG00000198589" "LRBA" "hsa:987; P50851; Q4W5J4; Q4W5L6; Q8NFQ0; Q9H2U3; Q9H2U4" "" "" "0" "0" "0.990" "0.933" "1.041" "1.094" "0.991" "0.957" "0.915" "0.980" "1.342" "489.6" "484.6" "457.0" "509.9" "535.7" "485.1" "468.7" "448.1" "479.7" "657.2" "" "" "" "" "" "" "" "" "" "" "259.2" "268.7" "261.7" "234.8" "289.8" "269.8" "275.8" "244.6" "269.1" "657.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5190108194104216904" "False" "High" "IsMasterProtein" "O43615" "Mitochondrial import inner membrane translocase subunit TIM44 OS=Homo sapiens OX=9606 GN=TIMM44 PE=1 SV=2" "0.000" "False" "22.249" "12" "6" "7" "6" "452" "51.3" "8.32" "20.19" "6" "transport;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf04280" "10469" "ENSG00000104980" "TIMM44" "A8K0R9; D6W664; hsa:10469; O43615; Q8N193" "" "Mitochondrial protein import" "1" "0" "1.005" "0.991" "0.968" "0.987" "0.995" "0.906" "0.841" "0.942" "1.541" "1014.1" "1019.3" "1005.2" "981.6" "1000.5" "1008.8" "919.2" "852.9" "955.3" "1562.5" "" "" "" "" "" "" "" "" "" "" "537.0" "565.1" "575.7" "452.1" "541.3" "561.1" "541.0" "465.6" "535.9" "1562.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6090359432096684388" "False" "High" "IsMasterProtein" "Q8NCN5" "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial OS=Homo sapiens OX=9606 GN=PDPR PE=1 SV=2" "0.000" "False" "22.236" "7" "6" "6" "6" "879" "99.3" "6.35" "15.99" "6" "" "mitochondrion;other cell component" "other molecular function" "Pf01266, Pf01571, Pf08669, Pf16350" "55066" "ENSG00000090857" "PDPR" "A7E298; A8K8Y7; B3KSE1; Q6AI20; Q6AWC9; Q8NCN5" "" "Regulation of pyruvate dehydrogenase (PDH) complex" "1" "0" "0.987" "0.973" "1.039" "0.962" "0.919" "0.965" "0.938" "0.883" "0.688" "708.8" "699.6" "689.4" "736.7" "682.0" "651.7" "683.9" "665.2" "626.1" "487.8" "" "" "" "" "" "" "" "" "" "" "375.3" "387.9" "394.8" "339.3" "369.0" "362.5" "402.5" "363.1" "351.2" "487.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8198800325193539681" "False" "High" "IsMasterProtein" "P30050" "Large ribosomal subunit protein uL11 OS=Homo sapiens OX=9606 GN=RPL12 PE=1 SV=1" "0.000" "False" "22.228" "42" "6" "10" "6" "165" "17.8" "9.42" "31.39" "6" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00298, Pf03946" "6136" "ENSG00000197958" "RPL12" "hsa:6136; P30050; Q5VVV2; Q6PB27" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.008" "1.067" "1.159" "1.086" "1.088" "1.418" "1.378" "1.386" "0.595" "731.5" "737.6" "780.3" "847.5" "794.2" "796.2" "1037.0" "1008.1" "1014.2" "435.6" "" "" "" "" "" "" "" "" "" "" "387.3" "409.0" "446.9" "390.3" "429.7" "442.9" "610.3" "550.3" "568.9" "435.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1669697587989024487" "False" "High" "IsMasterProtein" "Q96FW1" "Ubiquitin thioesterase OTUB1 OS=Homo sapiens OX=9606 GN=OTUB1 PE=1 SV=2" "0.000" "False" "22.225" "19" "4" "9" "4" "271" "31.3" "4.94" "23.55" "4" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf10275" "55611" "ENSG00000167770" "OTUB1" "hsa:55611; Q32Q78; Q96FW1; Q96II3; Q9NXQ4; Q9P0B8" "" "Ub-specific processing proteases; Ovarian tumor domain proteases" "2" "0" "0.961" "0.933" "1.024" "0.956" "0.973" "1.040" "1.069" "0.978" "0.816" "420.9" "404.7" "392.9" "430.8" "402.5" "409.7" "437.6" "449.9" "411.5" "343.4" "" "" "" "" "" "" "" "" "" "" "222.9" "224.4" "225.0" "198.4" "217.8" "227.9" "257.6" "245.6" "230.8" "343.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4746768512254432328" "False" "High" "IsMasterProtein" "Q9Y4X5" "E3 ubiquitin-protein ligase ARIH1 OS=Homo sapiens OX=9606 GN=ARIH1 PE=1 SV=2" "0.000" "False" "22.210" "9" "5" "6" "5" "557" "64.1" "5.08" "15.89" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00097, Pf01485, Pf19422, Pf21235" "25820" "ENSG00000166233" "ARIH1" "B2R6U3; hsa:25820; O76026; Q9H3T6; Q9UEN0; Q9UP39; Q9Y4X5" "" "PKR-mediated signaling; ISG15 antiviral mechanism; RSV-host interactions" "3" "0" "0.961" "0.980" "0.907" "0.958" "0.988" "0.967" "0.996" "0.992" "0.584" "793.6" "762.4" "777.8" "719.6" "760.3" "783.9" "767.4" "790.4" "787.3" "463.2" "" "" "" "" "" "" "" "" "" "" "420.2" "422.7" "445.4" "331.4" "411.4" "436.0" "451.7" "431.4" "441.6" "463.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5783897718523636057" "False" "High" "IsMasterProtein" "O95602" "DNA-directed RNA polymerase I subunit RPA1 OS=Homo sapiens OX=9606 GN=POLR1A PE=1 SV=2" "0.000" "False" "22.199" "4" "6" "7" "6" "1720" "194.7" "7.03" "15.78" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00623, Pf04983, Pf04997, Pf04998, Pf05000" "25885" "ENSG00000068654" "POLR1A" "B7Z7T0; D6W5M0; hsa:25885; O95602; Q0VG05; Q9UEH0; Q9UFT9" "Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "8" "0" "1.233" "1.197" "1.309" "1.219" "1.081" "1.283" "1.081" "1.053" "3.227" "145.9" "180.0" "174.6" "191.0" "177.8" "157.6" "187.2" "157.7" "153.6" "470.7" "" "" "" "" "" "" "" "" "" "" "77.3" "99.8" "100.0" "88.0" "96.2" "87.7" "110.2" "86.1" "86.2" "470.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3589965409300637784" "False" "High" "IsMasterProtein" "Q14691" "DNA replication complex GINS protein PSF1 OS=Homo sapiens OX=9606 GN=GINS1 PE=1 SV=1" "0.000" "False" "22.171" "28" "5" "9" "5" "196" "23.0" "7.39" "24.15" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes" "nucleus;other cell component" "" "Pf05916" "9837" "ENSG00000101003" "GINS1" "hsa:9837; Q14691; Q9NQE2; Q9NQI7" "" "Unwinding of DNA" "1" "0" "1.100" "1.133" "1.243" "1.136" "1.088" "1.020" "1.030" "1.081" "1.341" "193.7" "213.0" "219.5" "240.6" "220.1" "210.6" "197.5" "199.5" "209.4" "259.6" "" "" "" "" "" "" "" "" "" "" "102.5" "118.1" "125.7" "110.8" "119.1" "117.2" "116.2" "108.9" "117.5" "259.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6449496976955696731" "False" "High" "IsMasterProtein" "Q9UHR5" "SAP30-binding protein OS=Homo sapiens OX=9606 GN=SAP30BP PE=1 SV=1" "0.000" "False" "22.153" "14" "4" "6" "4" "308" "33.9" "4.84" "17.48" "4" "other biological processes" "cytoskeleton;nucleus" "" "Pf07818" "29115" "ENSG00000161526" "SAP30BP" "B3KML7; hsa:29115; Q8N1R5; Q8TDR8; Q96D27; Q9UHR5" "" "NoRC negatively regulates rRNA expression" "1" "0" "1.057" "1.070" "1.073" "1.098" "1.041" "1.129" "1.140" "1.097" "0.627" "279.1" "295.0" "298.8" "299.4" "306.6" "290.6" "315.3" "318.3" "306.3" "175.0" "" "" "" "" "" "" "" "" "" "" "147.8" "163.5" "171.1" "137.9" "165.9" "161.7" "185.6" "173.7" "171.8" "175.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2214301499697937672" "False" "High" "IsMasterProtein" "Q96C86" "m7GpppX diphosphatase OS=Homo sapiens OX=9606 GN=DCPS PE=1 SV=2" "0.000" "False" "22.153" "21" "7" "10" "7" "337" "38.6" "6.38" "27.56" "7" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05652, Pf11969" "28960" "ENSG00000110063" "DCPS" "hsa:28960; Q8NHL8; Q96C86; Q9Y2S5" "" "mRNA decay by 3' to 5' exoribonuclease" "1" "0" "0.938" "1.005" "1.060" "0.992" "0.981" "0.961" "1.086" "0.984" "0.622" "1779.5" "1668.3" "1788.1" "1885.5" "1765.3" "1745.4" "1709.3" "1932.4" "1750.9" "1107.1" "" "" "" "" "" "" "" "" "" "" "942.2" "925.0" "1024.0" "868.4" "955.1" "970.9" "1006.0" "1054.8" "982.2" "1107.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3053469202622973433" "False" "High" "IsMasterProtein" "Q7L591" "Docking protein 3 OS=Homo sapiens OX=9606 GN=DOK3 PE=1 SV=2" "0.000" "False" "22.146" "12" "5" "9" "5" "496" "53.3" "7.77" "26.61" "5" "signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf02174" "79930" "ENSG00000146094" "DOK3" "E9PAT0; H7BXS0; hsa:79930; Q7L591; Q8N864; Q9BQB3; Q9H666" "5q35 copy number variation" "Neutrophil degranulation" "2" "0" "1.096" "1.147" "1.159" "1.158" "1.032" "0.860" "0.985" "0.958" "1.385" "81.5" "89.3" "93.4" "94.4" "94.3" "84.1" "70.1" "80.3" "78.1" "112.9" "" "" "" "" "" "" "" "" "" "" "43.1" "49.5" "53.5" "43.5" "51.0" "46.8" "41.2" "43.8" "43.8" "112.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1870726190365747871" "False" "High" "IsMasterProtein" "P61160" "Actin-related protein 2 OS=Homo sapiens OX=9606 GN=ACTR2 PE=1 SV=1" "0.000" "False" "22.054" "15" "5" "9" "5" "394" "44.7" "6.74" "27.98" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "10097" "ENSG00000138071" "ACTR2" "B2RCP5; D6W5F4; E9PF41; hsa:10097; O15142; P61160; Q96C82" "Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways" "Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; EPHB-mediated forward signaling" "8" "0" "1.009" "1.001" "1.002" "1.028" "1.019" "1.019" "0.970" "1.029" "0.803" "691.5" "697.6" "692.5" "693.1" "710.6" "704.7" "704.9" "670.7" "711.2" "555.3" "" "" "" "" "" "" "" "" "" "" "366.1" "386.8" "396.6" "319.2" "384.5" "392.0" "414.9" "366.1" "399.0" "555.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7073830227573610312" "False" "High" "IsMasterProtein" "Q9NR45" "Sialic acid synthase OS=Homo sapiens OX=9606 GN=NANS PE=1 SV=2" "0.000" "False" "22.053" "16" "5" "7" "5" "359" "40.3" "6.74" "24.28" "5" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf03102, Pf08666" "54187" "ENSG00000095380" "NANS" "B2RE98; Q8WUV9; Q9BWS6; Q9NR45; Q9NVD4" "Sialylation" "Sialic acid metabolism" "2" "0" "0.929" "1.019" "0.977" "1.041" "1.075" "1.057" "1.085" "1.050" "0.741" "502.0" "466.3" "511.4" "490.7" "522.3" "539.6" "530.3" "544.7" "527.0" "372.0" "" "" "" "" "" "" "" "" "" "" "265.8" "258.5" "292.9" "226.0" "282.6" "300.2" "312.1" "297.3" "295.6" "372.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5911471042018297925" "False" "High" "IsMasterProtein" "Q8ND56" "Protein LSM14 homolog A OS=Homo sapiens OX=9606 GN=LSM14A PE=1 SV=3" "0.000" "False" "22.045" "12" "6" "12" "5" "463" "50.5" "9.52" "29.09" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "nucleic acid binding activity" "Pf09532, Pf12701" "26065" "ENSG00000257103; ENSG00000262860" "LSM14A" "B4DTG6; hsa:26065; Q76LX7; Q8ND56; Q96AR3; Q96K73; Q96SN5; Q9UFR3" "" "" "0" "0" "1.143" "1.061" "1.021" "1.050" "1.035" "1.064" "1.077" "0.989" "0.903" "490.9" "561.3" "520.9" "501.0" "515.6" "508.0" "522.4" "528.5" "485.5" "443.5" "" "" "" "" "" "" "" "" "" "" "259.9" "311.2" "298.3" "230.7" "279.0" "282.6" "307.4" "288.5" "272.4" "443.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7029493779746441827" "False" "High" "IsMasterProtein" "Q7L1Q6" "eIF5-mimic protein 2 OS=Homo sapiens OX=9606 GN=BZW1 PE=1 SV=1" "0.000" "False" "22.030" "16" "8" "9" "7" "419" "48.0" "5.92" "22.51" "8" "other biological processes" "other cell component" "" "Pf02020" "9689" "ENSG00000082153" "BZW1" "B4DLZ8; B4DWF7; hsa:9689; Q14281; Q15394; Q7L1Q6; Q9BUY0" "" "" "0" "0" "0.996" "0.973" "1.125" "1.051" "1.112" "1.069" "0.516" "1.007" "7.795" "548.1" "545.8" "533.3" "616.6" "575.9" "609.3" "586.1" "282.8" "551.9" "4272.5" "" "" "" "" "" "" "" "" "" "" "290.2" "302.6" "305.4" "284.0" "311.6" "338.9" "344.9" "154.4" "309.6" "4272.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8097806180956091720" "False" "High" "IsMasterProtein" "Q16576" "Histone-binding protein RBBP7 OS=Homo sapiens OX=9606 GN=RBBP7 PE=1 SV=1" "0.000" "False" "22.029" "18" "7" "18" "5" "425" "47.8" "5.05" "44.51" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12265" "5931" "ENSG00000102054" "RBBP7" "hsa:5931; Q16576; Q5JP00" "Retinoblastoma gene in cancer; Interactome of polycomb repressive complex 2 (PRC2) ; Effect of progerin on genes involved in progeria" "Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Activation of anterior HOX genes in hindbrain development during early embryogenesis; HCMV Early Events; Neddylation; Potential therapeutics for SARS; Deposition of new CENPA-containing nucleosomes at the centromere; Transcriptional Regulation by E2F6; HDACs deacetylate histones; RMTs methylate histone arginines; PKMTs methylate histone lysines; HATs acetylate histones; RNA Polymerase I Transcription Initiation; PRC2 methylates histones and DNA; Defective pyroptosis; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "20" "2" "1.009" "0.985" "0.968" "1.040" "1.047" "1.083" "1.081" "1.021" "0.959" "1483.0" "1496.0" "1460.1" "1436.0" "1542.2" "1553.1" "1606.6" "1603.7" "1514.5" "1421.8" "" "" "" "" "" "" "" "" "" "" "785.2" "829.4" "836.2" "661.3" "834.4" "863.9" "945.5" "875.4" "849.6" "1421.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3968134916858178565" "False" "High" "IsMasterProtein" "P61247" "Small ribosomal subunit protein eS1 OS=Homo sapiens OX=9606 GN=RPS3A PE=1 SV=2" "0.000" "False" "22.018" "19" "6" "7" "6" "264" "29.9" "9.73" "22.72" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01015" "6189" "ENSG00000145425; ENSG00000292158" "RPS3A" "B2R4D4; D3DP05; hsa:6189; P33443; P49241; P61247" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Peptide chain elongation; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.171" "1.104" "1.452" "1.112" "1.108" "1.323" "1.355" "1.359" "1.094" "1132.6" "1326.6" "1250.8" "1644.3" "1259.1" "1255.1" "1498.7" "1534.4" "1539.4" "1238.7" "" "" "" "" "" "" "" "" "" "" "599.7" "735.5" "716.3" "757.3" "681.2" "698.2" "882.0" "837.6" "863.6" "1238.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8551730055028160476" "False" "High" "IsMasterProtein" "P08579" "U2 small nuclear ribonucleoprotein B'' OS=Homo sapiens OX=9606 GN=SNRPB2 PE=1 SV=1" "0.000" "False" "22.013" "26" "6" "16" "4" "225" "25.5" "9.72" "33.92" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6629" "ENSG00000125870" "SNRPB2" "B2R7J3; D3DW21; hsa:6629; P08579; Q9UJD4" "mRNA processing; Ciliary landscape" "mRNA Splicing - Major Pathway" "3" "0" "0.926" "1.040" "0.980" "1.060" "1.086" "0.978" "1.086" "1.105" "0.801" "246.2" "228.1" "256.0" "241.4" "261.1" "267.5" "240.9" "267.4" "272.2" "197.2" "" "" "" "" "" "" "" "" "" "" "130.4" "126.5" "146.6" "111.2" "141.3" "148.8" "141.8" "146.0" "152.7" "197.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3575198767162097907" "False" "High" "IsMasterProtein" "Q9BXV9" "EKC/KEOPS complex subunit GON7 OS=Homo sapiens OX=9606 GN=GON7 PE=1 SV=2" "0.000" "False" "21.996" "53" "3" "3" "3" "100" "10.9" "4.27" "13.74" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf15387" "84520" "ENSG00000170270; ENSG00000275619" "GON7" "Q0D2N1; Q0P6C4; Q3B7W5; Q9BXV9" "" "" "0" "0" "0.948" "1.048" "0.860" "0.913" "0.753" "0.729" "0.859" "0.751" "0.409" "815.4" "772.6" "854.2" "701.5" "744.3" "613.7" "594.7" "700.1" "612.5" "333.5" "" "" "" "" "" "" "" "" "" "" "431.7" "428.4" "489.2" "323.1" "402.7" "341.4" "350.0" "382.2" "343.6" "333.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9100750251972445181" "False" "High" "IsMasterProtein" "Q14C86" "GTPase-activating protein and VPS9 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GAPVD1 PE=1 SV=2" "0.000" "False" "21.986" "4" "6" "8" "6" "1478" "164.9" "5.22" "16.44" "6" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00616, Pf02204, Pf18151" "26130" "ENSG00000165219" "GAPVD1" "A8MYK3; B0QZ62; B0QZ63; B0QZ64; hsa:26130; Q14C76; Q14C86; Q2Q1W1; Q8ND92; Q8WU86; Q96CZ4; Q9NXQ1; Q9P207; Q9Y4N0" "" "RAB GEFs exchange GTP for GDP on RABs; Clathrin-mediated endocytosis" "2" "0" "1.077" "1.139" "1.357" "1.297" "1.183" "1.780" "2.060" "1.904" "2.326" "222.2" "239.3" "253.2" "301.6" "288.2" "263.0" "395.5" "457.8" "423.2" "517.0" "" "" "" "" "" "" "" "" "" "" "117.7" "132.7" "145.0" "138.9" "155.9" "146.3" "232.8" "249.9" "237.4" "517.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7971041458510100973" "False" "High" "IsMasterProtein" "P61201" "COP9 signalosome complex subunit 2 OS=Homo sapiens OX=9606 GN=COPS2 PE=1 SV=1" "0.000" "False" "21.966" "13" "6" "12" "6" "443" "51.6" "5.53" "29.37" "6" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01399" "9318" "ENSG00000166200" "COPS2" "hsa:9318; O88950; P61201; Q15647; Q6FGP4; Q9BY54; Q9R249; Q9UNI2; Q9UNQ5" "Ciliary landscape" "Neddylation; DNA Damage Recognition in GG-NER; Formation of TC-NER Pre-Incision Complex; Cargo recognition for clathrin-mediated endocytosis; RHOBTB1 GTPase cycle" "6" "0" "0.972" "1.050" "1.088" "1.021" "1.067" "1.024" "1.018" "0.934" "0.690" "975.0" "947.7" "1023.6" "1060.7" "995.5" "1040.5" "998.1" "992.2" "911.1" "673.0" "" "" "" "" "" "" "" "" "" "" "516.3" "525.4" "586.2" "488.5" "538.6" "578.8" "587.4" "541.6" "511.1" "673.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "513337833647549896" "False" "High" "IsMasterProtein" "P11717" "Cation-independent mannose-6-phosphate receptor OS=Homo sapiens OX=9606 GN=IGF2R PE=1 SV=3" "0.000" "False" "21.955" "3" "7" "8" "7" "2491" "274.2" "5.94" "22.45" "7" "transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00040, Pf00878" "3482" "ENSG00000197081" "IGF2R" "hsa:3482; P11717; Q7Z7G9; Q96PT5" "TROP2 regulatory signaling" "Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network" "6" "0" "0.966" "1.018" "0.983" "1.039" "1.021" "1.019" "0.986" "0.955" "0.748" "423.8" "409.4" "431.6" "416.7" "440.6" "432.7" "432.0" "418.1" "404.8" "317.2" "" "" "" "" "" "" "" "" "" "" "224.4" "227.0" "247.2" "191.9" "238.4" "240.7" "254.3" "228.2" "227.1" "317.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1585168671336988915" "False" "High" "IsMasterProtein" "Q01433" "AMP deaminase 2 OS=Homo sapiens OX=9606 GN=AMPD2 PE=1 SV=3" "0.000" "False" "21.948" "7" "7" "8" "7" "825" "94.8" "6.55" "23.03" "7" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf19326" "271" "ENSG00000116337" "AMPD2" "A0A5F9UK94; B4DK50; B4DZI5; E9PNG0; hsa:271; Q01433; Q14856; Q14857; Q16686; Q16687; Q16688; Q16729; Q5T693; Q5T695; Q96IA1; Q9UDX8; Q9UDX9; Q9UMU4" "" "Purine salvage" "1" "0" "1.064" "0.977" "1.005" "1.025" "1.002" "0.962" "0.981" "1.011" "0.565" "1113.1" "1184.9" "1087.2" "1118.6" "1141.0" "1115.0" "1070.7" "1091.9" "1124.9" "628.8" "" "" "" "" "" "" "" "" "" "" "589.4" "656.9" "622.6" "515.2" "617.3" "620.2" "630.2" "596.0" "631.1" "628.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8376641896775859350" "False" "High" "IsMasterProtein" "O95104" "SR-related and CTD-associated factor 4 OS=Homo sapiens OX=9606 GN=SCAF4 PE=1 SV=3" "0.000" "False" "21.932" "5" "6" "8" "6" "1147" "125.8" "9.55" "22.62" "6" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076, Pf04818" "57466" "ENSG00000156304" "SCAF4" "C9JLZ0; hsa:57466; O95104; Q0P5W8; Q6P1M5; Q8N3I8; Q9UFM1; Q9ULP8" "" "" "0" "0" "0.989" "1.045" "1.111" "1.118" "1.058" "1.349" "1.216" "1.393" "3.734" "603.6" "596.7" "631.0" "670.7" "674.8" "638.7" "814.5" "734.3" "840.9" "2253.5" "" "" "" "" "" "" "" "" "" "" "319.6" "330.8" "361.4" "308.9" "365.1" "355.3" "479.4" "400.8" "471.7" "2253.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6767865713948388298" "False" "High" "IsMasterProtein" "P49720" "Proteasome subunit beta type-3 OS=Homo sapiens OX=9606 GN=PSMB3 PE=1 SV=2" "0.000" "False" "21.927" "30" "5" "9" "5" "205" "22.9" "6.55" "25.54" "5" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf00227" "5691" "ENSG00000275903; ENSG00000277791" "PSMB3" "hsa:5691; P31147; P49720; Q0P6J7; Q96E27" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of expression of SLITs and ROBOs; The role of GTSE1 in G2/M progression after G2 checkpoint; Orc1 removal from chromatin; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "0.999" "0.973" "0.952" "0.995" "1.008" "1.059" "1.046" "1.042" "0.592" "705.5" "704.7" "686.7" "671.8" "701.9" "711.4" "746.8" "738.2" "735.4" "417.7" "" "" "" "" "" "" "" "" "" "" "373.5" "390.7" "393.3" "309.4" "379.7" "395.7" "439.5" "402.9" "412.5" "417.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4701772359172858038" "False" "High" "IsMasterProtein" "P49790" "Nuclear pore complex protein Nup153 OS=Homo sapiens OX=9606 GN=NUP153 PE=1 SV=2" "0.000" "False" "21.909" "4" "5" "6" "5" "1475" "153.8" "8.73" "14.73" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00641, Pf08604, Pf10599" "9972" "ENSG00000124789" "NUP153" "B4DIK2; E7EPX5; F6QR24; hsa:9972; P49790; Q4LE47; Q5T9I7; Q7Z743" "TGF-beta signaling pathway" "Nuclear import of Rev protein; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; SUMOylation of DNA replication proteins; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "29" "0" "1.035" "1.042" "1.021" "1.205" "1.042" "1.224" "1.421" "1.349" "0.956" "260.1" "269.2" "270.9" "265.4" "313.4" "271.0" "318.2" "369.5" "350.8" "248.6" "" "" "" "" "" "" "" "" "" "" "137.7" "149.3" "155.1" "122.2" "169.6" "150.7" "187.3" "201.7" "196.8" "248.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5808192534094495875" "False" "High" "IsMasterProtein" "Q9HC35" "Echinoderm microtubule-associated protein-like 4 OS=Homo sapiens OX=9606 GN=EML4 PE=1 SV=3" "0.000" "False" "21.907" "6" "5" "6" "5" "981" "108.8" "6.40" "13.30" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf03451" "27436" "ENSG00000143924" "EML4" "A6H8Y6; A6P4T4; A6P4V4; B2RBK3; B2RTW7; B5MCW9; hsa:27436; Q3SWW0; Q53R29; Q53TW8; Q6PJ45; Q9HC35; Q9NV40" "Non-small cell lung cancer" "Signaling by ALK fusions and activated point mutants; EML4 and NUDC in mitotic spindle formation; ALK mutants bind TKIs" "4" "0" "1.025" "1.077" "1.006" "0.965" "0.996" "0.958" "1.042" "1.064" "1.763" "588.6" "603.1" "633.7" "592.0" "567.9" "586.0" "563.6" "613.2" "626.5" "1037.7" "" "" "" "" "" "" "" "" "" "" "311.7" "334.4" "362.9" "272.7" "307.3" "326.0" "331.7" "334.7" "351.4" "1037.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5953183427719841951" "False" "High" "IsMasterProtein" "P18615" "Negative elongation factor E OS=Homo sapiens OX=9606 GN=NELFE PE=1 SV=3" "0.000" "False" "21.881" "13" "4" "5" "4" "380" "43.2" "9.33" "16.44" "4" "other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "7936" "ENSG00000204356; ENSG00000206268; ENSG00000206357; ENSG00000229363; ENSG00000231044; ENSG00000233801" "NELFE" "A2BE08; B4DUN1; B4DYX9; hsa:7936; P18615; Q5JP74; Q5JP75; Q96F56; Q9NPK2" "Initiation of transcription and translation elongation at the HIV-1 LTR; 4p16.3 copy number variation" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "16" "0" "1.080" "1.186" "1.172" "1.247" "1.155" "1.227" "1.229" "1.122" "1.402" "532.4" "574.9" "631.6" "624.2" "664.0" "614.9" "653.2" "654.5" "597.4" "746.5" "" "" "" "" "" "" "" "" "" "" "281.9" "318.8" "361.7" "287.4" "359.2" "342.0" "384.4" "357.2" "335.1" "746.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1130211750852848646" "False" "High" "IsMasterProtein" "Q13404" "Ubiquitin-conjugating enzyme E2 variant 1 OS=Homo sapiens OX=9606 GN=UBE2V1 PE=1 SV=2" "0.000" "False" "21.823" "31" "5" "15" "3" "147" "16.5" "7.93" "43.43" "5" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00179" "387522; 7335" "ENSG00000244687" "UBE2V1" "E1P629; hsa:387522; hsa:7335; Q13403; Q13404; Q13532; Q5TGE0; Q5TGE3; Q96H34; Q9GZT0; Q9GZW1; Q9H4J3; Q9H4J4; Q9UKL1; Q9UM48; Q9UM49; Q9UM50" "IL-1 signaling pathway; Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway" "Downstream TCR signaling; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; CLEC7A (Dectin-1) signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Aggrephagy; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; TAK1-dependent IKK and NF-kappa-B activation ; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; activated TAK1 mediates p38 MAPK activation; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "19" "0" "0.992" "1.048" "0.948" "0.967" "0.976" "1.031" "1.066" "0.950" "0.563" "1074.2" "1066.0" "1125.8" "1018.5" "1038.9" "1048.7" "1107.9" "1144.9" "1020.9" "605.3" "" "" "" "" "" "" "" "" "" "" "568.8" "591.0" "644.7" "469.1" "562.1" "583.3" "652.0" "624.9" "572.7" "605.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8857038607970442570" "False" "High" "IsMasterProtein" "Q16836" "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=HADH PE=1 SV=3" "0.000" "False" "21.810" "18" "7" "16" "7" "314" "34.3" "8.85" "34.91" "7" "other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00725, Pf02737" "3033" "ENSG00000138796" "HADH" "hsa:3033; J3KQ17; O00324; O00397; O00753; Q16836; Q4W5B4" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; Amino acid metabolism; IL-18 signaling pathway; Mitochondrial fatty acid oxidation disorders" "Mitochondrial protein degradation; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA" "12" "0" "0.926" "0.954" "0.940" "0.949" "0.915" "0.822" "0.835" "0.786" "0.498" "3065.7" "2838.3" "2926.2" "2882.6" "2908.2" "2804.0" "2520.8" "2560.5" "2409.7" "1525.6" "" "" "" "" "" "" "" "" "" "" "1623.3" "1573.6" "1675.8" "1327.5" "1573.4" "1559.7" "1483.6" "1397.6" "1351.8" "1525.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5652350861994780505" "False" "High" "IsMasterProtein" "Q13480" "GRB2-associated-binding protein 1 OS=Homo sapiens OX=9606 GN=GAB1 PE=1 SV=2" "0.000" "False" "21.800" "7" "4" "5" "4" "694" "76.6" "5.96" "18.99" "4" "developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00169" "2549" "ENSG00000109458" "GAB1" "A8K152; hsa:2549; Q13480; Q4W5G2; Q6P1W2" "Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Alpha 6 beta 4 signaling pathway; Hepatocyte growth factor receptor signaling; IL6 signaling pathway; BDNF-TrkB signaling; VEGFA-VEGFR2 signaling; Embryonic stem cell pluripotency pathways; MET in type 1 papillary renal cell carcinoma; Ras signaling; EGF/EGFR signaling pathway; Fragile X syndrome; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; GDNF signaling; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; 5q35 copy number variation; ErbB signaling pathway" "RET signaling; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; MET activates RAP1 and RAC1; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); PI3K Cascade; PI3K events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; GAB1 signalosome; Signaling by FGFR1 in disease; PI-3K cascade:FGFR1; PI-3K cascade:FGFR2; Signaling by FGFR2 in disease; PI-3K cascade:FGFR3; PI-3K cascade:FGFR4; Signaling by FGFR3 in disease; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR4 in disease; MET activates PI3K/AKT signaling; MET activates PTPN11; MET receptor recycling; Activated NTRK2 signals through PI3K" "46" "0" "0.862" "0.846" "0.998" "1.088" "0.961" "1.066" "0.868" "0.976" "1.243" "90.6" "78.1" "76.6" "90.4" "98.6" "87.1" "96.6" "78.7" "88.4" "112.6" "" "" "" "" "" "" "" "" "" "" "48.0" "43.3" "43.9" "41.6" "53.3" "48.4" "56.8" "42.9" "49.6" "112.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7727744455345483682" "False" "High" "IsMasterProtein" "Q13868" "Exosome complex component RRP4 OS=Homo sapiens OX=9606 GN=EXOSC2 PE=1 SV=2" "0.000" "False" "21.764" "23" "6" "6" "6" "293" "32.8" "7.50" "14.52" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf14382, Pf15985, Pf21266" "23404" "ENSG00000130713" "EXOSC2" "A3KFL3; A3KFL4; B4DKK6; hsa:23404; Q13868; Q9NUY4" "Ciliary landscape" "ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Major pathway of rRNA processing in the nucleolus and cytosol; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "7" "0" "0.997" "0.954" "1.112" "1.010" "1.004" "1.116" "1.011" "0.942" "0.505" "958.9" "955.9" "914.4" "1066.6" "968.1" "962.4" "1069.9" "969.7" "903.0" "484.3" "" "" "" "" "" "" "" "" "" "" "507.7" "530.0" "523.7" "491.2" "523.8" "535.3" "629.7" "529.3" "506.5" "484.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2794156240078795368" "False" "High" "IsMasterProtein" "Q8NEZ5" "F-box only protein 22 OS=Homo sapiens OX=9606 GN=FBXO22 PE=1 SV=1" "0.000" "False" "21.757" "15" "6" "11" "6" "403" "44.5" "7.03" "24.77" "6" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00646, Pf10442" "26263" "ENSG00000167196" "FBXO22" "hsa:26263; Q0D2P8; Q6PIL5; Q8IXW3; Q8NEZ5; Q9H824; Q9UKC0" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "1.025" "0.930" "1.107" "1.133" "1.024" "1.008" "1.056" "0.971" "0.848" "359.5" "368.4" "334.3" "398.0" "407.1" "368.2" "362.2" "379.6" "348.9" "304.7" "" "" "" "" "" "" "" "" "" "" "190.3" "204.2" "191.4" "183.3" "220.3" "204.8" "213.2" "207.2" "195.7" "304.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6610589870849209696" "False" "High" "IsMasterProtein" "Q9NZ63" "Splicing factor C9orf78 OS=Homo sapiens OX=9606 GN=C9orf78 PE=1 SV=1" "0.000" "False" "21.744" "22" "7" "9" "7" "289" "33.7" "6.74" "23.83" "7" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf07052" "51759" "ENSG00000136819" "C9orf78" "B3KPX8; Q8WVU6; Q9NT39; Q9NZ63" "" "mRNA Splicing - Major Pathway" "1" "0" "1.084" "1.148" "1.085" "1.027" "1.043" "1.120" "1.183" "1.080" "0.583" "1057.2" "1145.6" "1213.6" "1146.9" "1085.8" "1103.0" "1184.3" "1250.4" "1141.5" "616.3" "" "" "" "" "" "" "" "" "" "" "559.8" "635.2" "695.0" "528.2" "587.5" "613.5" "697.0" "682.6" "640.3" "616.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7990537509462567326" "False" "High" "IsMasterProtein" "P16298" "Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PPP3CB PE=1 SV=2" "0.000" "False" "21.707" "10" "5" "10" "1" "524" "59.0" "5.91" "26.02" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00149" "5532" "ENSG00000107758" "PPP3CB" "hsa:5532; P16298; P16299; Q5F2F9; Q8N1F0; Q8N3W4" "Physiological and pathological hypertrophy of the heart; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Amyotrophic lateral sclerosis (ALS); Initiation of transcription and translation elongation at the HIV-1 LTR; MAPK signaling pathway; Wnt signaling; Alzheimer's disease; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "FCERI mediated Ca+2 mobilization; Ca2+ pathway; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT; DARPP-32 events; ROBO receptors bind AKAP5" "16" "0" "1.304" "1.441" "1.432" "1.145" "1.233" "1.331" "1.328" "1.088" "1.132" "43.5" "56.8" "62.8" "62.4" "49.9" "53.7" "58.0" "57.8" "47.4" "49.3" "" "" "" "" "" "" "" "" "" "" "23.1" "31.5" "35.9" "28.7" "27.0" "29.9" "34.1" "31.6" "26.6" "49.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6548479852001098502" "False" "High" "IsMasterProtein" "P10253" "Lysosomal alpha-glucosidase OS=Homo sapiens OX=9606 GN=GAA PE=1 SV=4" "0.000" "False" "21.700" "7" "6" "9" "6" "952" "105.3" "6.00" "26.05" "6" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00088, Pf01055, Pf13802, Pf21365" "2548" "ENSG00000171298; ENSG00000291507" "GAA" "hsa:2548; P10253; Q09GN4; Q14351; Q16302; Q8IWE7" "" "Neutrophil degranulation; Glycogen breakdown (glycogenolysis); Glycogen storage disease type II (GAA)" "3" "0" "1.078" "0.989" "1.096" "1.027" "0.936" "1.055" "1.008" "0.849" "0.557" "600.8" "647.8" "594.4" "658.2" "617.0" "562.5" "633.9" "605.6" "509.9" "334.6" "" "" "" "" "" "" "" "" "" "" "318.1" "359.2" "340.4" "303.1" "333.8" "312.9" "373.1" "330.6" "286.0" "334.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2527179580342077355" "False" "High" "IsMasterProtein" "Q9NUQ9" "CYFIP-related Rac1 interactor B OS=Homo sapiens OX=9606 GN=CYRIB PE=1 SV=1" "0.000" "False" "21.690" "15" "5" "12" "5" "324" "36.7" "6.06" "24.97" "5" "cell organization and biogenesis;other biological processes" "non-structural extracellular;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf07159" "51571" "ENSG00000153310" "CYRIB" "hsa:51571; Q96AZ5; Q9NUQ9; Q9NW21; Q9NZE7" "" "Platelet degranulation" "1" "0" "1.075" "1.063" "0.834" "0.910" "0.957" "1.211" "0.972" "0.975" "0.474" "1879.2" "2020.5" "1998.4" "1567.8" "1710.8" "1798.9" "2276.0" "1826.6" "1832.7" "891.4" "" "" "" "" "" "" "" "" "" "" "995.0" "1120.2" "1144.5" "722.0" "925.6" "1000.6" "1339.5" "997.1" "1028.1" "891.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5285928462194255524" "False" "High" "IsMasterProtein" "Q9H6T3" "RNA polymerase II-associated protein 3 OS=Homo sapiens OX=9606 GN=RPAP3 PE=1 SV=2" "0.000" "False" "21.689" "9" "5" "5" "5" "665" "75.7" "6.84" "15.54" "5" "other biological processes" "cytosol;other cell component" "" "Pf00515, Pf13181, Pf13877" "79657" "ENSG00000005175" "RPAP3" "B4DRW9; hsa:79657; Q6PHR5; Q9H6T3" "" "" "0" "0" "0.995" "0.985" "1.109" "1.167" "1.252" "1.833" "2.005" "1.843" "1.828" "256.8" "255.4" "253.1" "284.8" "299.6" "321.4" "470.6" "514.9" "473.3" "469.4" "" "" "" "" "" "" "" "" "" "" "136.0" "141.6" "144.9" "131.1" "162.1" "178.8" "277.0" "281.0" "265.5" "469.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7222850354556005820" "False" "High" "IsMasterProtein" "P20839" "Inosine-5'-monophosphate dehydrogenase 1 OS=Homo sapiens OX=9606 GN=IMPDH1 PE=1 SV=2" "0.000" "False" "21.667" "10" "6" "14" "4" "514" "55.4" "6.90" "42.30" "6" "other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00478, Pf00571" "3614" "ENSG00000106348" "IMPDH1" "A4D0Z6; A4D0Z7; A6NDW5; A6NNI6; B3KNP7; B3KVM8; B4DE09; C9JV30; hsa:3614; J3KNX8; P20839; Q8N194; Q96NU2" "" "Neutrophil degranulation; Potential therapeutics for SARS; Purine ribonucleoside monophosphate biosynthesis; Azathioprine ADME" "4" "0" "0.947" "0.968" "0.957" "1.024" "1.006" "0.803" "0.789" "0.731" "0.529" "680.3" "644.0" "658.7" "651.3" "696.9" "684.5" "546.2" "536.6" "497.1" "360.2" "" "" "" "" "" "" "" "" "" "" "360.2" "357.1" "377.2" "299.9" "377.1" "380.7" "321.5" "292.9" "278.8" "360.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8378095313839820512" "False" "High" "IsMasterProtein" "P15923" "Transcription factor E2-alpha OS=Homo sapiens OX=9606 GN=TCF3 PE=1 SV=1" "0.000" "False" "21.659" "7" "4" "5" "4" "654" "67.6" "6.47" "13.16" "4" "DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "6929" "ENSG00000071564" "TCF3" "hsa:6929; P15883; P15923; Q14208; Q14635; Q14636; Q2TB39; Q2TB40; Q9UPI9" "Ectoderm differentiation; Ectoderm differentiation; Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; lncRNA in canonical Wnt signaling and colorectal cancer; Neurogenesis regulation in the olfactory epithelium; Sudden infant death syndrome (SIDS) susceptibility pathways" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Myogenesis" "9" "0" "1.028" "1.140" "0.982" "1.165" "1.179" "1.401" "1.663" "1.636" "1.884" "466.6" "479.7" "531.7" "458.2" "543.7" "550.0" "653.9" "775.8" "763.4" "879.0" "" "" "" "" "" "" "" "" "" "" "247.1" "266.0" "304.5" "211.0" "294.2" "305.9" "384.8" "423.5" "428.2" "879.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7968684939462891772" "False" "High" "IsMasterProtein" "O14974" "Protein phosphatase 1 regulatory subunit 12A OS=Homo sapiens OX=9606 GN=PPP1R12A PE=1 SV=1" "0.000" "False" "21.633" "6" "6" "6" "6" "1030" "115.2" "5.40" "16.71" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00023, Pf15898" "4659" "ENSG00000058272" "PPP1R12A" "B4DZ09; F8VWB4; hsa:4659; O14974; Q2NKL4; Q569H0; Q86WU3; Q8NFR6; Q9BYH0" "Focal adhesion; Hippo-Merlin signaling dysregulation; Regulation of actin cytoskeleton" "Regulation of PLK1 Activity at G2/M Transition; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "8" "0" "0.923" "1.025" "1.199" "1.192" "1.080" "1.374" "1.368" "1.428" "1.817" "386.7" "356.9" "396.4" "463.5" "461.0" "417.7" "531.2" "528.9" "552.3" "702.8" "" "" "" "" "" "" "" "" "" "" "204.8" "197.9" "227.0" "213.5" "249.4" "232.4" "312.6" "288.7" "309.8" "702.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4990507016878311040" "False" "High" "IsMasterProtein" "P42126" "Enoyl-CoA delta isomerase 1, mitochondrial OS=Homo sapiens OX=9606 GN=ECI1 PE=1 SV=1" "0.000" "False" "21.620" "13" "4" "8" "4" "302" "32.8" "8.54" "23.40" "4" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00378" "1632" "ENSG00000167969" "ECI1" "A8K512; hsa:1632; P42126; Q13290; Q7Z2L6; Q7Z2L7; Q9BUB8; Q9BW05; Q9UDG6" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; Mitochondrial fatty acid oxidation disorders" "Mitochondrial protein degradation; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" "5" "0" "0.840" "0.904" "0.855" "0.858" "0.917" "0.958" "0.903" "0.933" "0.434" "609.8" "512.3" "551.5" "521.7" "523.5" "559.5" "584.2" "550.7" "569.2" "264.8" "" "" "" "" "" "" "" "" "" "" "322.9" "284.0" "315.8" "240.2" "283.2" "311.2" "343.8" "300.6" "319.3" "264.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1274747088330592999" "False" "High" "IsMasterProtein" "O94973" "AP-2 complex subunit alpha-2 OS=Homo sapiens OX=9606 GN=AP2A2 PE=1 SV=2" "0.000" "False" "21.593" "8" "8" "11" "3" "939" "103.9" "6.96" "27.38" "8" "transport" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf02296, Pf02883" "161" "ENSG00000183020" "AP2A2" "hsa:161; O75403; O94973; Q53ET1; Q96SI8" "Synaptic vesicle pathway; GABA receptor signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Cell lineage map for neuronal differentiation" "Potential therapeutics for SARS; Recycling pathway of L1; MHC class II antigen presentation; Neutrophil degranulation; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "18" "0" "1.101" "1.025" "0.996" "1.054" "1.107" "1.022" "0.977" "0.976" "1.366" "282.8" "311.3" "289.9" "281.7" "298.1" "313.1" "289.1" "276.3" "276.1" "386.2" "" "" "" "" "" "" "" "" "" "" "149.7" "172.6" "166.0" "129.7" "161.3" "174.2" "170.1" "150.8" "154.9" "386.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3867715510256549408" "False" "High" "IsMasterProtein" "P49757" "Protein numb homolog OS=Homo sapiens OX=9606 GN=NUMB PE=1 SV=2" "0.000" "False" "21.553" "9" "6" "6" "6" "651" "70.8" "8.51" "14.57" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00640, Pf06311" "8650" "ENSG00000133961" "NUMB" "B1P2N5; B1P2N6; B1P2N7; B1P2N8; B1P2N9; B4E2B1; hsa:8650; P49757; Q6NUQ7; Q86SY1; Q8WW73; Q9UBG1; Q9UEQ4; Q9UKE8; Q9UKE9; Q9UKF0; Q9UQJ4" "Notch signaling; VEGFA-VEGFR2 signaling; Head and neck squamous cell carcinoma; Neurogenesis regulation in the olfactory epithelium; TROP2 regulatory signaling; Notch signaling pathway" "Recycling pathway of L1; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; Activated NOTCH1 Transmits Signal to the Nucleus" "10" "0" "0.997" "0.958" "1.134" "1.053" "1.122" "1.002" "1.034" "1.052" "0.884" "317.7" "316.6" "304.4" "360.2" "334.5" "356.6" "318.3" "328.4" "334.1" "280.7" "" "" "" "" "" "" "" "" "" "" "168.2" "175.5" "174.3" "165.9" "181.0" "198.4" "187.3" "179.2" "187.4" "280.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1177482447512558462" "False" "High" "IsMasterProtein" "Q9NUV9" "GTPase IMAP family member 4 OS=Homo sapiens OX=9606 GN=GIMAP4 PE=1 SV=1" "0.000" "False" "21.537" "14" "5" "7" "5" "329" "37.5" "7.81" "22.26" "5" "" "cytosol;other cell component" "other molecular function" "Pf04548" "55303" "ENSG00000133574" "GIMAP4" "hsa:55303; Q9NUV9" "" "" "0" "0" "0.958" "0.952" "1.059" "1.170" "0.928" "1.051" "0.938" "0.888" "1.019" "571.8" "548.0" "544.4" "605.5" "668.8" "530.5" "601.0" "536.1" "507.6" "582.8" "" "" "" "" "" "" "" "" "" "" "302.7" "303.8" "311.8" "278.9" "361.9" "295.1" "353.7" "292.6" "284.7" "582.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7841395992400372766" "False" "High" "IsMasterProtein" "Q9NVG8" "TBC1 domain family member 13 OS=Homo sapiens OX=9606 GN=TBC1D13 PE=1 SV=3" "0.000" "False" "21.500" "12" "5" "7" "5" "400" "46.5" "5.24" "20.30" "5" "transport" "other membranes;cytosol" "enzyme regulator activity;other molecular function" "Pf00566" "54662" "ENSG00000107021" "TBC1D13" "A7E2E7; B3KW04; B9EGJ8; hsa:54662; Q5T270; Q5T271; Q9NVG8" "" "TBC/RABGAPs" "1" "0" "0.997" "0.959" "0.967" "1.191" "1.057" "0.996" "1.013" "0.946" "0.934" "397.5" "396.3" "381.2" "384.4" "473.5" "420.3" "396.0" "402.5" "376.0" "371.4" "" "" "" "" "" "" "" "" "" "" "210.5" "219.7" "218.3" "177.0" "256.2" "233.8" "233.1" "219.7" "210.9" "371.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4228584982071455131" "False" "High" "IsMasterProtein" "Q92769" "Histone deacetylase 2 OS=Homo sapiens OX=9606 GN=HDAC2 PE=1 SV=2" "0.000" "False" "21.467" "11" "6" "9" "2" "488" "55.3" "5.91" "20.46" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00850" "3066" "ENSG00000196591" "HDAC2" "B3KRS5; B4DL58; E1P561; hsa:3066; Q5SRI8; Q5SZ86; Q8NEH4; Q92769" "Cell cycle; Neural crest differentiation; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Effect of progerin on genes involved in progeria; Ciliary landscape; 7q11.23 copy number variation syndrome; SARS-CoV-2 innate immunity evasion and cell-specific immune response; TAR syndrome; Notch signaling pathway" "Factors involved in megakaryocyte development and platelet production; Regulation of MECP2 expression and activity; Regulation of TP53 Activity through Acetylation; Potential therapeutics for SARS; SUMOylation of chromatin organization proteins; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Regulation of PTEN gene transcription; RNA Polymerase I Transcription Initiation; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; STAT3 nuclear events downstream of ALK signaling; EGR2 and SOX10-mediated initiation of Schwann cell myelination; MECP2 regulates neuronal receptors and channels" "30" "0" "0.959" "0.957" "0.946" "0.948" "0.998" "0.912" "1.006" "1.065" "1.041" "317.2" "304.2" "303.5" "300.0" "300.9" "316.7" "289.3" "319.2" "337.8" "330.4" "" "" "" "" "" "" "" "" "" "" "168.0" "168.7" "173.8" "138.2" "162.8" "176.2" "170.2" "174.2" "189.5" "330.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1566902771694482530" "False" "High" "IsMasterProtein" "P51153" "Ras-related protein Rab-13 OS=Homo sapiens OX=9606 GN=RAB13 PE=1 SV=1" "0.000" "False" "21.416" "23" "5" "9" "2" "203" "22.8" "9.19" "21.55" "5" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5872" "ENSG00000143545" "RAB13" "A8K6B5; D3DV67; hsa:5872; P51153; Q5U0A6; Q6GPG6; Q96GU4" "Leukocyte-intrinsic Hippo pathway functions" "RAB GEFs exchange GTP for GDP on RABs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAB geranylgeranylation" "4" "0" "0.941" "0.940" "1.001" "0.952" "0.998" "0.934" "0.965" "0.943" "0.784" "384.3" "361.8" "361.4" "384.7" "366.0" "383.5" "359.0" "370.8" "362.6" "301.2" "" "" "" "" "" "" "" "" "" "" "203.5" "200.6" "207.0" "177.2" "198.0" "213.3" "211.3" "202.4" "203.4" "301.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8211975543562738760" "False" "High" "IsMasterProtein" "P13984" "General transcription factor IIF subunit 2 OS=Homo sapiens OX=9606 GN=GTF2F2 PE=1 SV=2" "0.000" "False" "21.407" "22" "7" "10" "7" "249" "28.4" "9.23" "31.09" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf02270, Pf17683" "2963" "ENSG00000188342" "GTF2F2" "A6NNS5; hsa:2963; P13984; Q5W0H3" "Eukaryotic transcription initiation" "TP53 Regulates Transcription of DNA Repair Genes; Estrogen-dependent gene expression; Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM" "33" "0" "0.953" "0.990" "0.840" "0.941" "0.982" "1.012" "1.007" "1.027" "0.707" "1236.1" "1177.4" "1223.8" "1038.7" "1163.6" "1213.4" "1251.0" "1244.3" "1269.2" "873.7" "" "" "" "" "" "" "" "" "" "" "654.5" "652.8" "700.9" "478.4" "629.6" "675.0" "736.3" "679.2" "712.0" "873.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4174205388023222362" "False" "High" "IsMasterProtein" "Q96H20" "Vacuolar-sorting protein SNF8 OS=Homo sapiens OX=9606 GN=SNF8 PE=1 SV=1" "0.000" "False" "21.383" "14" "3" "4" "3" "258" "28.8" "6.65" "13.57" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04157" "11267" "ENSG00000159210" "SNF8" "hsa:11267; Q8IXY3; Q96H20; Q9UN50" "" "HCMV Late Events; Endosomal Sorting Complex Required For Transport (ESCRT)" "2" "0" "0.990" "1.011" "1.096" "0.979" "1.054" "1.030" "0.985" "0.965" "0.902" "389.3" "385.6" "393.8" "426.8" "381.3" "410.5" "401.2" "383.6" "375.9" "351.3" "" "" "" "" "" "" "" "" "" "" "206.2" "213.8" "225.5" "196.6" "206.3" "228.3" "236.1" "209.4" "210.9" "351.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9192930488046834202" "False" "High" "IsMasterProtein" "P25789" "Proteasome subunit alpha type-4 OS=Homo sapiens OX=9606 GN=PSMA4 PE=1 SV=1" "0.000" "False" "21.380" "19" "6" "17" "6" "261" "29.5" "7.72" "46.47" "6" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf00227, Pf10584" "5685" "ENSG00000041357" "PSMA4" "D3DW86; hsa:5685; P25789; Q53XP2; Q567Q5; Q8TBD1" "Proteasome degradation; Alzheimer's disease and miRNA effects; Exercise-induced circadian regulation; Alzheimer's disease" "Degradation of DVL; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "0.916" "0.938" "0.874" "0.891" "0.936" "0.967" "0.952" "0.919" "0.502" "1958.0" "1794.1" "1836.9" "1712.1" "1743.7" "1832.6" "1893.2" "1864.0" "1799.6" "982.9" "" "" "" "" "" "" "" "" "" "" "1036.7" "994.7" "1052.0" "788.5" "943.4" "1019.4" "1114.2" "1017.5" "1009.5" "982.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1839612719642205858" "False" "High" "IsMasterProtein" "P09417" "Dihydropteridine reductase OS=Homo sapiens OX=9606 GN=QDPR PE=1 SV=2" "0.000" "False" "21.374" "25" "4" "8" "4" "244" "25.8" "7.37" "22.23" "4" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00106" "5860" "ENSG00000151552" "QDPR" "A8K158; B3KW71; hsa:5860; P09417; Q53F52; Q9H3M5" "" "Phenylalanine metabolism" "1" "0" "1.038" "1.047" "1.094" "1.200" "1.069" "0.996" "1.039" "1.014" "0.610" "600.8" "623.5" "629.2" "657.4" "720.9" "642.4" "598.4" "624.5" "609.2" "366.4" "" "" "" "" "" "" "" "" "" "" "318.1" "345.7" "360.3" "302.8" "390.0" "357.4" "352.2" "340.9" "341.7" "366.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1785172786280045072" "False" "High" "IsMasterProtein" "P06730" "Eukaryotic translation initiation factor 4E OS=Homo sapiens OX=9606 GN=EIF4E PE=1 SV=2" "0.000" "False" "21.332" "22" "4" "13" "4" "217" "25.1" "6.15" "39.87" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01652" "1977" "ENSG00000151247" "EIF4E" "B7Z6V1; D6RCQ6; hsa:1977; P06730; Q96E95" "Translation factors; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Interleukin-1 (IL-1) structural pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prader-Willi and Angelman syndrome; PI3K-Akt signaling pathway; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Hypertrophy model; Interferon type I signaling pathways" "Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; mTORC1-mediated signalling; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "33" "0" "0.962" "1.034" "0.946" "1.068" "1.067" "0.929" "1.081" "0.963" "0.636" "787.6" "757.8" "814.6" "745.0" "841.5" "840.6" "731.9" "851.8" "758.1" "500.7" "" "" "" "" "" "" "" "" "" "" "417.0" "420.1" "466.5" "343.1" "455.3" "467.6" "430.7" "465.0" "425.3" "500.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4811509789942253503" "False" "High" "IsMasterProtein" "Q7Z6M1" "Rab9 effector protein with kelch motifs OS=Homo sapiens OX=9606 GN=RABEPK PE=1 SV=1" "0.000" "False" "21.311" "12" "4" "6" "4" "372" "40.5" "6.25" "20.19" "4" "transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01344, Pf07646, Pf13415" "10244" "ENSG00000136933" "RABEPK" "A8K403; hsa:10244; O00568; Q69YR2; Q6FHA4; Q6IBG7; Q6P092; Q7Z6M1; Q86Y76; Q9BWB1" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "0.923" "0.967" "1.023" "1.022" "1.096" "0.994" "0.984" "1.031" "0.664" "577.8" "533.2" "558.7" "591.0" "590.4" "633.0" "574.0" "568.7" "595.5" "383.8" "" "" "" "" "" "" "" "" "" "" "305.9" "295.6" "320.0" "272.2" "319.5" "352.1" "337.8" "310.5" "334.0" "383.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8434101151437963191" "False" "High" "IsMasterProtein" "Q7Z2K8" "G protein-regulated inducer of neurite outgrowth 1 OS=Homo sapiens OX=9606 GN=GPRIN1 PE=1 SV=2" "0.000" "False" "21.310" "7" "9" "9" "9" "1008" "102.3" "8.06" "18.93" "9" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf15235" "114787" "ENSG00000169258" "GPRIN1" "C9JM70; hsa:114787; Q7Z2K8; Q8ND74; Q96PZ4" "MECP2 and associated Rett syndrome; 5q35 copy number variation" "MECP2 regulates neuronal receptors and channels" "3" "0" "0.926" "1.014" "0.981" "0.998" "0.889" "0.943" "0.955" "0.923" "0.601" "760.6" "704.5" "770.9" "746.2" "759.2" "676.3" "717.1" "726.3" "702.1" "457.0" "" "" "" "" "" "" "" "" "" "" "402.7" "390.6" "441.5" "343.6" "410.7" "376.2" "422.0" "396.4" "393.9" "457.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1630318732500359632" "False" "High" "IsMasterProtein" "P62280" "Small ribosomal subunit protein uS17 OS=Homo sapiens OX=9606 GN=RPS11 PE=1 SV=3" "0.000" "False" "21.296" "26" "5" "7" "5" "158" "18.4" "10.30" "18.69" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00366, Pf16205" "6205" "ENSG00000142534" "RPS11" "B2R4F5; hsa:6205; P04643; P62280; Q498Y6; Q6IRY0" "VEGFA-VEGFR2 signaling; IL-18 signaling pathway; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "21" "0" "1.080" "1.165" "1.236" "1.238" "1.213" "1.249" "1.318" "1.449" "1.666" "481.1" "519.7" "560.5" "594.5" "595.7" "583.7" "600.9" "634.0" "697.1" "801.5" "" "" "" "" "" "" "" "" "" "" "254.8" "288.1" "321.0" "273.8" "322.3" "324.7" "353.7" "346.1" "391.1" "801.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8302543892740036521" "False" "High" "IsMasterProtein" "P82970" "High mobility group nucleosome-binding domain-containing protein 5 OS=Homo sapiens OX=9606 GN=HMGN5 PE=1 SV=1" "0.000" "False" "21.289" "16" "5" "7" "5" "282" "31.5" "4.55" "23.61" "5" "cell organization and biogenesis;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "79366" "ENSG00000198157" "HMGN5" "hsa:79366; P82970; Q5JSL1" "" "" "0" "0" "0.886" "1.019" "0.964" "0.920" "0.850" "0.969" "0.950" "0.929" "0.451" "2129.3" "1886.4" "2169.3" "2053.1" "1959.7" "1810.6" "2063.7" "2023.9" "1978.0" "961.2" "" "" "" "" "" "" "" "" "" "" "1127.5" "1045.9" "1242.3" "945.5" "1060.3" "1007.1" "1214.6" "1104.7" "1109.6" "961.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4952075756115425488" "False" "High" "IsMasterProtein" "Cont_P34955" "Alpha-1-antiproteinase OS=Bos taurus OX=9913 GN=SERPINA1 PE=1 SV=1" "0.000" "True" "21.282" "14" "7" "10" "7" "416" "46.1" "6.52" "31.15" "7" "" "non-structural extracellular;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00079" "109575576; 280699" "ENSBIXG00000014418; ENSBIXG00005018236; ENSBTAG00000018843" "SERPINA1" "A0A4W2DYT6; A0A6P5DQE7; biu:109575576; bta:280699; P34955; Q3SZS3" "Complement and coagulation cascades; NRF2 pathway" "Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo concentration in the ER; COPII-mediated vesicle transport" "8" "0" "1.036" "1.107" "1.074" "1.313" "1.180" "1.135" "1.505" "1.495" "0.612" "1008.4" "1044.3" "1116.1" "1082.6" "1324.3" "1190.1" "1144.1" "1517.8" "1507.4" "617.1" "" "" "" "" "" "" "" "" "" "" "534.0" "579.0" "639.2" "498.6" "716.5" "662.0" "673.3" "828.5" "845.6" "617.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1583280322088088435" "False" "High" "IsMasterProtein" "Q9NPF4" "tRNA N6-adenosine threonylcarbamoyltransferase OS=Homo sapiens OX=9606 GN=OSGEP PE=1 SV=1" "0.000" "False" "21.241" "21" "6" "8" "6" "335" "36.4" "6.35" "17.27" "6" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00814" "55644" "ENSG00000092094; ENSG00000291794" "OSGEP" "hsa:55644; Q6IAC3; Q9NPF4" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.940" "0.962" "0.982" "0.910" "0.977" "0.944" "0.947" "0.888" "0.622" "629.3" "591.7" "605.1" "617.7" "572.5" "614.9" "594.0" "596.0" "559.0" "391.5" "" "" "" "" "" "" "" "" "" "" "333.2" "328.0" "346.5" "284.5" "309.8" "342.1" "349.6" "325.3" "313.6" "391.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7705673583208632788" "False" "High" "IsMasterProtein" "P04183" "Thymidine kinase, cytosolic OS=Homo sapiens OX=9606 GN=TK1 PE=1 SV=2" "0.000" "False" "21.224" "12" "3" "7" "3" "234" "25.5" "8.51" "23.87" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00265" "7083" "ENSG00000167900" "TK1" "B2RC58; hsa:7083; P04183; Q969V0; Q9UMG9" "Fluoropyrimidine activity; Pyrimidine metabolism" "Pyrimidine salvage; G1/S-Specific Transcription" "4" "0" "1.120" "1.080" "0.998" "0.942" "1.139" "1.110" "1.174" "1.035" "0.593" "152.7" "171.0" "164.9" "152.3" "143.9" "173.9" "169.4" "179.3" "158.0" "90.5" "" "" "" "" "" "" "" "" "" "" "80.9" "94.8" "94.4" "70.2" "77.9" "96.8" "99.7" "97.9" "88.6" "90.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9119616111706856744" "False" "High" "IsMasterProtein" "Q9ULZ3" "Apoptosis-associated speck-like protein containing a CARD OS=Homo sapiens OX=9606 GN=PYCARD PE=1 SV=2" "0.000" "False" "21.223" "19" "4" "4" "4" "195" "21.6" "6.34" "14.35" "4" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00619, Pf02758" "29108" "ENSG00000103490" "PYCARD" "hsa:29108; Q96D12; Q9BSZ5; Q9HBD0; Q9NXJ8; Q9ULZ3" "Nucleotide-binding oligomerization domain (NOD) pathway; Nanomaterial-induced inflammasome activation; TYROBP causal network in microglia; Acute viral myocarditis; Cytosolic DNA-sensing pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Prostaglandin signaling" "Neutrophil degranulation; The AIM2 inflammasome; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; SARS-CoV-1 activates/modulates innate immune responses; CLEC7A/inflammasome pathway" "13" "0" "0.913" "0.922" "0.908" "0.966" "0.966" "0.946" "0.965" "1.003" "0.658" "668.5" "610.0" "616.1" "607.1" "645.8" "645.8" "632.7" "645.3" "670.6" "439.6" "" "" "" "" "" "" "" "" "" "" "354.0" "338.2" "352.9" "279.6" "349.4" "359.2" "372.3" "352.2" "376.2" "439.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4340156669496060526" "False" "High" "IsMasterProtein" "Q9Y3C6" "Peptidyl-prolyl cis-trans isomerase-like 1 OS=Homo sapiens OX=9606 GN=PPIL1 PE=1 SV=1" "0.000" "False" "21.222" "36" "5" "11" "5" "166" "18.2" "7.99" "28.68" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "other molecular function" "Pf00160" "51645" "ENSG00000137168" "PPIL1" "hsa:51645; O15001; Q5TDC9; Q9Y3C6" "" "mRNA Splicing - Major Pathway" "1" "0" "1.021" "0.977" "1.025" "1.066" "0.967" "1.097" "1.092" "1.069" "0.972" "836.9" "854.3" "817.9" "857.5" "892.4" "809.0" "918.0" "913.9" "894.4" "813.8" "" "" "" "" "" "" "" "" "" "" "443.1" "473.6" "468.4" "394.9" "482.8" "450.0" "540.2" "498.8" "501.8" "813.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7944368975479606522" "False" "High" "IsMasterProtein" "O94979" "Protein transport protein Sec31A OS=Homo sapiens OX=9606 GN=SEC31A PE=1 SV=3" "0.000" "False" "21.214" "5" "7" "10" "7" "1220" "132.9" "6.89" "22.01" "7" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf12931" "22872" "ENSG00000138674" "SEC31A" "B4DIW6; B7ZKZ7; B7ZL00; H7C2W3; hsa:22872; O94979; Q17RR5; Q5H9P6; Q5XG74; Q659G7; Q6ZU90; Q7LCX9; Q86TJ0; Q8IZH4; Q9P048; Q9P0A6; Q9UM05; Q9UM06" "Sterol regulatory element-binding proteins (SREBP) signaling" "Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes; Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "6" "0" "1.049" "0.960" "1.201" "1.135" "1.100" "1.232" "0.904" "1.225" "4.977" "294.8" "309.3" "283.1" "354.1" "334.7" "324.2" "363.1" "266.5" "361.0" "1467.1" "" "" "" "" "" "" "" "" "" "" "156.1" "171.5" "162.2" "163.1" "181.1" "180.4" "213.7" "145.5" "202.5" "1467.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6546315403352841289" "False" "High" "IsMasterProtein" "Q9Y2B0" "Protein canopy homolog 2 OS=Homo sapiens OX=9606 GN=CNPY2 PE=1 SV=1" "0.000" "False" "21.182" "25" "4" "7" "4" "182" "20.6" "4.92" "20.13" "4" "other biological processes" "ER/Golgi" "" "Pf11938" "10330" "ENSG00000257727" "CNPY2" "B2R7B9; Q9UHE9; Q9Y2B0" "" "" "0" "0" "1.041" "1.031" "1.008" "0.996" "0.933" "0.954" "1.087" "0.967" "0.608" "1244.1" "1294.8" "1282.1" "1254.1" "1238.7" "1160.3" "1187.2" "1352.3" "1202.7" "756.9" "" "" "" "" "" "" "" "" "" "" "658.7" "717.9" "734.2" "577.5" "670.2" "645.4" "698.7" "738.1" "674.7" "756.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5119731611670534936" "False" "High" "IsMasterProtein" "O60610" "Protein diaphanous homolog 1 OS=Homo sapiens OX=9606 GN=DIAPH1 PE=1 SV=2" "0.000" "False" "21.164" "5" "7" "9" "7" "1272" "141.3" "5.41" "23.41" "7" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf02181, Pf06346, Pf06367, Pf06371" "1729" "ENSG00000131504" "DIAPH1" "A6NF18; B7ZKW2; E9PEZ2; hsa:1729; O60610; Q17RN4; Q59FH8; Q9UC76" "Microtubule cytoskeleton regulation; AGE/RAGE pathway; Focal adhesion; Type 2 papillary renal cell carcinoma; Regulation of actin cytoskeleton; G13 signaling pathway" "RHOC GTPase cycle; RHOA GTPase cycle; RHO GTPases Activate Formins; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; ERBB2 Regulates Cell Motility" "14" "0" "1.036" "1.053" "1.133" "1.067" "1.059" "1.092" "0.700" "1.086" "5.257" "465.6" "482.3" "490.1" "527.6" "496.7" "493.1" "508.2" "325.7" "505.8" "2447.3" "" "" "" "" "" "" "" "" "" "" "246.5" "267.4" "280.7" "243.0" "268.7" "274.3" "299.1" "177.8" "283.7" "2447.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8194850060938304098" "False" "High" "IsMasterProtein" "Q8N5I9" "NOP protein chaperone 1 OS=Homo sapiens OX=9606 GN=NOPCHAP1 PE=1 SV=2" "0.000" "False" "21.157" "24" "5" "5" "5" "185" "20.1" "5.22" "16.83" "5" "cell organization and biogenesis" "nucleus" "other molecular function" "Pf15370" "121053" "ENSG00000151131" "NOPCHAP1" "Q8N5I9" "" "" "0" "0" "1.003" "1.043" "1.034" "0.975" "0.947" "0.994" "1.121" "1.002" "0.728" "1008.2" "1011.0" "1051.9" "1042.8" "983.5" "954.4" "1002.5" "1130.6" "1009.9" "734.5" "" "" "" "" "" "" "" "" "" "" "533.9" "560.5" "602.4" "480.2" "532.1" "530.9" "590.0" "617.2" "566.5" "734.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1188306556528865133" "False" "High" "IsMasterProtein" "Q15691" "Microtubule-associated protein RP/EB family member 1 OS=Homo sapiens OX=9606 GN=MAPRE1 PE=1 SV=3" "0.000" "False" "21.139" "23" "5" "12" "5" "268" "30.0" "5.14" "37.19" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf03271" "22919" "ENSG00000101367" "MAPRE1" "B2R6I7; E1P5M8; hsa:22919; Q15691; Q3KQS8" "Microtubule cytoskeleton regulation; HDAC6 interactions in the central nervous system" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of PLK1 Activity at G2/M Transition; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2" "16" "0" "0.984" "1.056" "0.985" "0.923" "1.069" "0.948" "0.980" "1.006" "1.492" "656.2" "645.5" "692.9" "646.3" "605.5" "701.6" "622.2" "643.2" "659.8" "979.3" "" "" "" "" "" "" "" "" "" "" "347.5" "357.9" "396.8" "297.6" "327.6" "390.3" "366.2" "351.1" "370.1" "979.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4480157126328656163" "False" "High" "IsMasterProtein" "O75937" "DnaJ homolog subfamily C member 8 OS=Homo sapiens OX=9606 GN=DNAJC8 PE=1 SV=2" "0.000" "False" "21.127" "32" "10" "12" "10" "253" "29.8" "9.06" "22.31" "10" "" "cytosol;nucleus;other cell component" "other molecular function" "Pf00226" "22826" "ENSG00000126698" "DNAJC8" "B4DUU4; D3DPM0; hsa:22826; O75937; Q6IBA4; Q8N4Z5; Q9P051; Q9P067" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.757" "0.798" "0.803" "0.758" "0.990" "0.773" "0.785" "0.733" "0.735" "1262.2" "955.0" "1007.3" "1013.8" "956.8" "1249.1" "975.7" "991.2" "925.0" "927.5" "" "" "" "" "" "" "" "" "" "" "668.4" "529.5" "576.9" "466.9" "517.7" "694.8" "574.3" "541.0" "518.9" "927.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7527974897574347786" "False" "High" "IsMasterProtein" "Q16778" "Histone H2B type 2-E OS=Homo sapiens OX=9606 GN=H2BC21 PE=1 SV=3" "0.000" "False" "21.106" "45" "6" "16" "6" "126" "13.9" "10.32" "34.27" "6" "cell organization and biogenesis;stress response" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "8349" "ENSG00000184678" "H2BC21" "A3KMC7; A8K110; hsa:8349; Q16778; Q4KMY1; Q5QNX0; Q9UE88" "" "Amyloid fiber formation; Meiotic synapsis; HCMV Late Events; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HCMV Early Events; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Replacement of protamines by nucleosomes in the male pronucleus" "44" "0" "1.020" "1.066" "1.275" "1.043" "1.166" "0.991" "1.041" "1.412" "1.486" "556.3" "567.6" "593.2" "709.1" "580.2" "648.5" "551.3" "578.9" "785.8" "826.8" "" "" "" "" "" "" "" "" "" "" "294.6" "314.7" "339.7" "326.6" "313.9" "360.7" "324.4" "316.0" "440.8" "826.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6123043622142940735" "False" "High" "IsMasterProtein" "P55145" "Mesencephalic astrocyte-derived neurotrophic factor OS=Homo sapiens OX=9606 GN=MANF PE=1 SV=3" "0.000" "False" "21.104" "24" "5" "6" "5" "182" "20.7" "8.69" "14.44" "5" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf10208, Pf20145" "7873" "ENSG00000145050" "MANF" "hsa:7873; P55145; Q14CX4; Q86U67; Q96IS4" "Orexin receptor pathway" "Platelet degranulation" "2" "0" "0.998" "1.039" "1.034" "0.964" "1.014" "0.955" "1.092" "1.005" "0.563" "316.8" "316.3" "329.3" "327.5" "305.4" "321.4" "302.7" "346.0" "318.5" "178.3" "" "" "" "" "" "" "" "" "" "" "167.8" "175.3" "188.6" "150.8" "165.2" "178.8" "178.1" "188.8" "178.7" "178.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7237194878275625611" "False" "High" "IsMasterProtein" "Q9Y224" "RNA transcription, translation and transport factor protein OS=Homo sapiens OX=9606 GN=RTRAF PE=1 SV=1" "0.000" "False" "21.061" "20" "6" "7" "6" "244" "28.1" "6.65" "18.62" "6" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10036" "51637" "ENSG00000087302" "RTRAF" "hsa:51637; Q9Y224" "" "tRNA processing in the nucleus" "1" "0" "1.004" "1.029" "0.950" "1.106" "1.113" "1.345" "1.348" "1.371" "1.569" "677.6" "680.5" "697.2" "644.0" "749.3" "754.3" "911.5" "913.2" "928.8" "1063.0" "" "" "" "" "" "" "" "" "" "" "358.8" "377.3" "399.3" "296.6" "405.4" "419.6" "536.5" "498.5" "521.0" "1063.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2410269861090895387" "False" "High" "IsMasterProtein" "Q9NZT2" "Opioid growth factor receptor OS=Homo sapiens OX=9606 GN=OGFR PE=1 SV=3" "0.000" "False" "21.050" "9" "5" "5" "5" "677" "73.3" "4.84" "16.93" "5" "other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf04664, Pf04680" "11054" "ENSG00000060491" "OGFR" "hsa:11054; O96029; Q4VXW5; Q96CM2; Q9BQW1; Q9H4H0; Q9H7J5; Q9NZT2; Q9NZT3; Q9NZT4" "" "" "0" "0" "0.930" "0.883" "1.022" "1.076" "0.974" "0.912" "0.607" "0.734" "5.143" "373.0" "347.0" "329.3" "381.1" "401.4" "363.3" "340.2" "226.5" "273.7" "1918.3" "" "" "" "" "" "" "" "" "" "" "197.5" "192.4" "188.6" "175.5" "217.2" "202.1" "200.2" "123.7" "153.5" "1918.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9034564449228548140" "False" "High" "IsMasterProtein" "O75223" "Gamma-glutamylcyclotransferase OS=Homo sapiens OX=9606 GN=GGCT PE=1 SV=1" "0.000" "False" "21.027" "32" "6" "9" "6" "188" "21.0" "5.14" "24.01" "6" "cell organization and biogenesis;signal transduction" "cytosol" "other molecular function" "Pf13772" "79017" "ENSG00000006625" "GGCT" "B2RDN0; B8ZZN4; B8ZZR8; hsa:79017; O75223; Q9BS37" "" "Glutathione synthesis and recycling" "1" "0" "0.965" "0.959" "0.934" "0.772" "0.807" "0.799" "0.951" "0.779" "0.580" "1240.1" "1196.6" "1188.9" "1158.4" "957.5" "1001.0" "990.5" "1179.6" "965.7" "718.9" "" "" "" "" "" "" "" "" "" "" "656.6" "663.4" "680.9" "533.5" "518.0" "556.8" "583.0" "643.9" "541.7" "718.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5479844659917987073" "False" "High" "IsMasterProtein" "Q9NQ48" "Leucine zipper transcription factor-like protein 1 OS=Homo sapiens OX=9606 GN=LZTFL1 PE=1 SV=1" "0.000" "False" "20.981" "20" "6" "6" "6" "299" "34.6" "5.36" "14.62" "6" "other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf15294" "54585" "ENSG00000163818" "LZTFL1" "B3KSI9; B4E0K7; hsa:54585; Q8TC61; Q9NQ48; Q9NQ56" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Ciliopathies; Bardet-Biedl syndrome" "BBSome-mediated cargo-targeting to cilium" "5" "0" "0.875" "0.936" "1.159" "0.893" "0.963" "0.847" "0.872" "0.905" "0.569" "758.7" "663.8" "710.5" "879.6" "677.5" "730.4" "642.4" "661.8" "686.4" "431.9" "" "" "" "" "" "" "" "" "" "" "401.7" "368.0" "406.9" "405.1" "366.5" "406.3" "378.1" "361.3" "385.1" "431.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "410623999248744867" "False" "High" "IsMasterProtein" "Q6PKG0" "La-related protein 1 OS=Homo sapiens OX=9606 GN=LARP1 PE=1 SV=2" "0.000" "False" "20.898" "6" "7" "8" "7" "1096" "123.4" "8.82" "20.20" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf05383, Pf21071" "23367" "ENSG00000155506" "LARP1" "hsa:23367; O94836; Q6PKG0; Q8N4M2; Q8NB73; Q9UFD7" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "4" "0" "1.108" "1.036" "1.130" "0.966" "1.151" "1.469" "1.573" "1.534" "1.032" "376.3" "416.9" "389.7" "425.1" "363.5" "433.1" "552.9" "592.0" "577.2" "388.3" "" "" "" "" "" "" "" "" "" "" "199.2" "231.2" "223.2" "195.8" "196.7" "240.9" "325.4" "323.2" "323.8" "388.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-929965012723082693" "False" "High" "IsMasterProtein" "Q969E4" "Transcription elongation factor A protein-like 3 OS=Homo sapiens OX=9606 GN=TCEAL3 PE=1 SV=1" "0.000" "False" "20.867" "24" "4" "5" "4" "200" "22.5" "4.92" "13.89" "4" "" "nucleus" "" "Pf04538" "85012" "ENSG00000196507" "TCEAL3" "D3DXA4; hsa:85012; Q969E4" "" "" "0" "0" "0.950" "0.974" "0.957" "0.953" "0.814" "0.909" "0.808" "0.768" "0.562" "480.4" "456.5" "467.7" "459.8" "457.9" "391.2" "436.9" "388.3" "368.7" "270.2" "" "" "" "" "" "" "" "" "" "" "254.4" "253.1" "267.9" "211.7" "247.7" "217.6" "257.1" "211.9" "206.9" "270.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5034217840069919209" "False" "High" "IsMasterProtein" "O95721" "Synaptosomal-associated protein 29 OS=Homo sapiens OX=9606 GN=SNAP29 PE=1 SV=1" "0.000" "False" "20.834" "21" "5" "6" "5" "258" "29.0" "5.81" "17.35" "5" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "" "9342" "ENSG00000099940" "SNAP29" "hsa:9342; O95721" "Ciliary landscape; 22q11.2 copy number variation syndrome" "Intra-Golgi traffic; Neutrophil degranulation" "4" "0" "1.163" "1.186" "0.974" "1.060" "1.099" "0.948" "1.038" "1.089" "1.007" "336.9" "391.9" "399.5" "328.1" "357.2" "370.1" "319.3" "349.8" "366.9" "339.3" "" "" "" "" "" "" "" "" "" "" "178.4" "217.3" "228.8" "151.1" "193.3" "205.9" "187.9" "190.9" "205.8" "339.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4528933939237155494" "False" "High" "IsMasterProtein" "P25490" "Transcriptional repressor protein YY1 OS=Homo sapiens OX=9606 GN=YY1 PE=1 SV=2" "0.000" "False" "20.798" "13" "5" "5" "5" "414" "44.7" "6.25" "15.10" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "7528" "ENSG00000100811" "YY1" "hsa:7528; P25490; Q14935" "Sterol regulatory element-binding proteins (SREBP) signaling; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Pleural mesothelioma" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; UCH proteinases; DNA Damage Recognition in GG-NER; TFAP2 (AP-2) family regulates transcription of growth factors and their receptors" "8" "0" "0.974" "0.998" "1.048" "1.114" "1.018" "1.063" "0.962" "1.140" "2.107" "638.8" "622.4" "637.6" "669.4" "711.6" "650.0" "679.2" "614.8" "728.3" "1345.6" "" "" "" "" "" "" "" "" "" "" "338.2" "345.1" "365.2" "308.3" "385.0" "361.6" "399.7" "335.6" "408.6" "1345.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2088552440920446999" "False" "High" "IsMasterProtein" "Q9Y570" "Protein phosphatase methylesterase 1 OS=Homo sapiens OX=9606 GN=PPME1 PE=1 SV=3" "0.000" "False" "20.779" "13" "5" "6" "5" "386" "42.3" "5.97" "14.30" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf12697" "51400" "ENSG00000214517" "PPME1" "B3KMU6; B5MEE7; hsa:51400; J3QT22; Q8WYG8; Q9NVT5; Q9UI18; Q9Y570" "" "Cyclin A/B1/B2 associated events during G2/M transition" "1" "0" "0.956" "0.938" "0.928" "0.920" "0.983" "0.977" "0.946" "0.914" "0.709" "685.5" "655.5" "643.1" "636.1" "630.7" "674.1" "669.6" "648.8" "626.6" "485.9" "" "" "" "" "" "" "" "" "" "" "363.0" "363.4" "368.3" "293.0" "341.3" "374.9" "394.1" "354.2" "351.5" "485.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3689472973843486022" "False" "High" "IsMasterProtein" "O00505" "Importin subunit alpha-4 OS=Homo sapiens OX=9606 GN=KPNA3 PE=1 SV=2" "0.000" "False" "20.701" "12" "6" "8" "4" "521" "57.8" "4.94" "19.73" "6" "cell organization and biogenesis;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3839" "ENSG00000102753" "KPNA3" "hsa:3839; O00191; O00505; O43195; Q5JVM9; Q8IYQ9; Q96AA7" "" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways" "2" "2" "1.028" "0.975" "1.050" "1.008" "1.022" "1.135" "0.921" "1.076" "1.874" "775.7" "797.4" "756.3" "814.8" "782.1" "792.8" "880.1" "714.8" "834.3" "1453.6" "" "" "" "" "" "" "" "" "" "" "410.7" "442.1" "433.2" "375.2" "423.1" "441.0" "518.0" "390.2" "468.0" "1453.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3125031583536319160" "False" "High" "IsMasterProtein" "P05204" "Non-histone chromosomal protein HMG-17 OS=Homo sapiens OX=9606 GN=HMGN2 PE=1 SV=3" "0.000" "False" "20.694" "29" "3" "11" "3" "90" "9.4" "9.99" "31.09" "3" "cell organization and biogenesis;stress response;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "3151" "ENSG00000198830" "HMGN2" "hsa:3151; P05204; Q0VGD5; Q6FGI5; Q96C64" "" "" "0" "0" "0.845" "1.143" "1.105" "0.602" "0.769" "0.725" "0.943" "0.739" "0.355" "2375.0" "2007.8" "2715.1" "2624.4" "1429.9" "1825.9" "1721.2" "2240.6" "1756.1" "842.6" "" "" "" "" "" "" "" "" "" "" "1257.6" "1113.2" "1554.9" "1208.6" "773.6" "1015.7" "1013.0" "1223.1" "985.1" "842.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5818593354028515611" "False" "High" "IsMasterProtein" "P56524" "Histone deacetylase 4 OS=Homo sapiens OX=9606 GN=HDAC4 PE=1 SV=3" "0.000" "False" "20.692" "6" "7" "8" "7" "1084" "119.0" "6.96" "20.60" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00850, Pf12203" "9759" "ENSG00000068024" "HDAC4" "E9PGB9; F5GX36; hsa:9759; P56524; Q86YH7; Q9UND6" "MicroRNAs in cardiomyocyte hypertrophy; Genes targeted by miRNAs in adipocytes; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; Endochondral ossification; Endochondral ossification with skeletal dysplasias; CAMKK2 pathway; 2q37 copy number variation syndrome" "SUMOylation of chromatin organization proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; SUMOylation of intracellular receptors; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX3 regulates p14-ARF; RUNX2 regulates chondrocyte maturation" "20" "0" "0.906" "0.896" "0.970" "0.973" "1.022" "0.971" "0.877" "1.076" "0.616" "403.2" "365.2" "361.3" "391.0" "392.1" "412.2" "391.7" "353.5" "433.8" "248.2" "" "" "" "" "" "" "" "" "" "" "213.5" "202.5" "206.9" "180.1" "212.2" "229.3" "230.5" "192.9" "243.3" "248.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5761790178817742854" "False" "High" "IsMasterProtein" "Q96P70" "Importin-9 OS=Homo sapiens OX=9606 GN=IPO9 PE=1 SV=3" "0.000" "False" "20.685" "4" "5" "10" "5" "1041" "115.9" "4.81" "29.12" "5" "transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03810" "55705" "ENSG00000198700" "IPO9" "B1ASV5; hsa:55705; Q8N1Y1; Q8N3I2; Q8NCG9; Q96P70; Q96SU6; Q9NW01; Q9P0A8; Q9ULM8" "" "" "0" "0" "1.079" "0.986" "1.054" "1.026" "1.060" "1.586" "1.336" "1.476" "2.261" "326.3" "352.0" "321.6" "344.1" "334.6" "345.9" "517.5" "435.8" "481.8" "737.9" "" "" "" "" "" "" "" "" "" "" "172.8" "195.2" "184.2" "158.5" "181.1" "192.4" "304.6" "237.9" "270.3" "737.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7075703887839209806" "False" "High" "IsMasterProtein" "Q14CX7" "N-alpha-acetyltransferase 25, NatB auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA25 PE=1 SV=1" "0.000" "False" "20.662" "6" "7" "8" "7" "972" "112.2" "6.64" "19.75" "7" "" "cytosol;ER/Golgi;other cell component" "" "Pf09797" "80018" "ENSG00000111300" "NAA25" "A0JLU7; hsa:80018; Q14CX7; Q6MZH1; Q7Z4N6; Q9H911" "" "" "0" "0" "0.999" "0.959" "0.962" "0.965" "0.982" "0.933" "0.986" "0.911" "0.635" "1598.0" "1596.4" "1533.0" "1537.3" "1542.2" "1569.6" "1491.4" "1575.1" "1455.9" "1014.3" "" "" "" "" "" "" "" "" "" "" "846.2" "885.1" "877.9" "708.0" "834.4" "873.1" "877.7" "859.8" "816.7" "1014.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2638301692080516805" "False" "High" "IsMasterProtein" "O95817" "BAG family molecular chaperone regulator 3 OS=Homo sapiens OX=9606 GN=BAG3 PE=1 SV=3" "0.000" "False" "20.660" "10" "6" "9" "6" "575" "61.6" "6.95" "21.75" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00397, Pf02179" "9531" "ENSG00000151929" "BAG3" "A8K5L8; hsa:9531; O95817; Q3B763; Q9NT20; Q9P120" "Cell interactions of the pancreatic cancer microenvironment" "Regulation of HSF1-mediated heat shock response" "2" "0" "0.983" "0.964" "1.016" "0.966" "0.998" "0.954" "1.039" "1.022" "0.535" "827.4" "813.5" "797.4" "840.7" "799.0" "825.7" "789.5" "859.4" "845.4" "442.4" "" "" "" "" "" "" "" "" "" "" "438.1" "451.0" "456.7" "387.2" "432.3" "459.3" "464.7" "469.1" "474.3" "442.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9120785921578449656" "False" "High" "IsMasterProtein" "A0A0B4J2D5" "Putative glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial OS=Homo sapiens OX=9606 GN=GATD3B PE=5 SV=1" "0.000" "False" "20.584" "22" "6" "15" "6" "268" "28.1" "8.27" "35.13" "6" "" "mitochondrion" "" "" "8209" "" "GATD3B" "A0A0B4J2D5; A6NFJ6; A6NJY7; hsa:8209; O00650; O00660; O15011; O15012; P30042; P55346; P78474; Q92505; Q92507" "Gastric cancer network 1" "" "1" "0" "1.074" "1.078" "1.032" "1.021" "1.078" "1.026" "1.121" "1.058" "0.544" "1259.1" "1351.9" "1357.2" "1299.1" "1285.0" "1357.2" "1291.4" "1411.1" "1332.3" "685.0" "" "" "" "" "" "" "" "" "" "" "666.7" "749.5" "777.3" "598.3" "695.3" "754.9" "760.0" "770.3" "747.4" "685.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6802113826893248650" "False" "High" "IsMasterProtein" "P07108" "Acyl-CoA-binding protein OS=Homo sapiens OX=9606 GN=DBI PE=1 SV=2" "0.000" "False" "20.578" "23" "1" "6" "1" "87" "10.0" "6.57" "15.46" "1" "other metabolic processes;other biological processes" "ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00887" "1622" "ENSG00000155368" "DBI" "B8ZWD2; B8ZWD6; B8ZWD7; hsa:1622; P07108; P08869; Q4VWZ6; Q53SQ7; Q6IB48; Q9UCI8" "Sterol regulatory element-binding proteins (SREBP) signaling; PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Fatty acid transporters" "Mitochondrial Fatty Acid Beta-Oxidation" "6" "0" "0.919" "1.006" "1.028" "0.958" "0.935" "1.008" "0.975" "0.812" "0.486" "857.1" "787.3" "862.3" "881.4" "820.8" "801.0" "864.3" "835.7" "695.8" "416.3" "" "" "" "" "" "" "" "" "" "" "453.8" "436.5" "493.8" "405.9" "444.1" "445.5" "508.7" "456.2" "390.3" "416.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2020319621841403457" "False" "High" "IsMasterProtein" "P07741" "Adenine phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=APRT PE=1 SV=2" "0.000" "False" "20.567" "37" "7" "15" "7" "180" "19.6" "6.02" "34.89" "7" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00156" "353" "ENSG00000198931" "APRT" "G5E9J2; hsa:353; P07741; Q3KP55; Q68DF9" "" "Neutrophil degranulation; Purine salvage; Defective APRT disrupts adenine salvage" "3" "0" "1.120" "1.063" "0.911" "0.947" "0.984" "1.277" "0.973" "0.952" "0.630" "1293.2" "1447.8" "1374.3" "1178.3" "1224.1" "1272.2" "1650.9" "1257.9" "1230.7" "814.1" "" "" "" "" "" "" "" "" "" "" "684.7" "802.7" "787.1" "542.7" "662.3" "707.6" "971.6" "686.6" "690.4" "814.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7337665348008384774" "False" "High" "IsMasterProtein" "O60701" "UDP-glucose 6-dehydrogenase OS=Homo sapiens OX=9606 GN=UGDH PE=1 SV=1" "0.000" "False" "20.553" "11" "4" "4" "4" "494" "55.0" "7.12" "14.69" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;nucleus" "other molecular function" "Pf00984, Pf03720, Pf03721" "7358" "ENSG00000109814" "UGDH" "B3KUU2; B4DN25; hsa:7358; O60589; O60701" "UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "Formation of the active cofactor, UDP-glucuronate" "3" "0" "1.000" "0.954" "0.885" "1.065" "1.021" "0.875" "0.871" "0.899" "0.700" "782.7" "782.7" "747.0" "692.5" "833.5" "799.3" "685.1" "681.5" "703.5" "548.1" "" "" "" "" "" "" "" "" "" "" "414.5" "433.9" "427.8" "318.9" "450.9" "444.6" "403.2" "372.0" "394.7" "548.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "272489793728892869" "False" "High" "IsMasterProtein" "Q14696" "LRP chaperone MESD OS=Homo sapiens OX=9606 GN=MESD PE=1 SV=2" "0.000" "False" "20.512" "24" "6" "9" "6" "234" "26.1" "7.78" "22.66" "6" "cell-cell signaling;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf10185" "23184" "ENSG00000117899" "MESD" "B4DW84; D3DW96; hsa:23184; Q14696; Q969U1" "" "" "0" "0" "0.936" "1.028" "0.980" "0.936" "0.952" "0.949" "0.949" "0.912" "0.611" "1620.7" "1516.6" "1666.2" "1588.1" "1517.7" "1542.8" "1537.4" "1538.8" "1477.7" "989.7" "" "" "" "" "" "" "" "" "" "" "858.2" "840.9" "954.2" "731.4" "821.2" "858.2" "904.8" "840.0" "828.9" "989.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3565723958770546681" "False" "High" "IsMasterProtein" "Q08378" "Golgin subfamily A member 3 OS=Homo sapiens OX=9606 GN=GOLGA3 PE=1 SV=2" "0.000" "False" "20.473" "5" "7" "7" "7" "1498" "167.3" "5.44" "19.05" "7" "" "other membranes;cytosol;ER/Golgi;nucleus" "" "" "2802" "ENSG00000090615" "GOLGA3" "A5PKX6; hsa:2802; O43241; Q08378; Q6P9C7; Q86XW3; Q8TDA9; Q8WZA3" "" "RND2 GTPase cycle" "1" "0" "1.118" "1.035" "1.042" "0.999" "0.998" "1.030" "0.990" "0.996" "1.162" "718.4" "803.4" "743.9" "748.3" "717.4" "717.1" "739.8" "711.6" "715.8" "834.9" "" "" "" "" "" "" "" "" "" "" "380.4" "445.4" "426.0" "344.6" "388.1" "398.9" "435.4" "388.4" "401.6" "834.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7016247097338811422" "False" "High" "IsMasterProtein" "Q9NW64" "Pre-mRNA-splicing factor RBM22 OS=Homo sapiens OX=9606 GN=RBM22 PE=1 SV=1" "0.000" "False" "20.437" "11" "5" "6" "5" "420" "46.9" "8.54" "14.12" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf21369" "55696" "ENSG00000086589" "RBM22" "A6NDM5; B4DLI9; hsa:55696; O95607; Q9NW64" "" "mRNA Splicing - Major Pathway" "1" "0" "1.073" "1.015" "1.062" "1.127" "1.166" "1.200" "1.189" "1.234" "1.914" "398.8" "428.0" "404.6" "423.6" "449.5" "465.0" "478.4" "474.0" "491.9" "763.2" "" "" "" "" "" "" "" "" "" "" "211.1" "237.3" "231.7" "195.1" "243.2" "258.7" "281.5" "258.8" "275.9" "763.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3397920079809031089" "False" "High" "IsMasterProtein" "Q7Z5R6" "Amyloid beta A4 precursor protein-binding family B member 1-interacting protein OS=Homo sapiens OX=9606 GN=APBB1IP PE=1 SV=1" "0.000" "False" "20.433" "9" "6" "10" "6" "666" "73.1" "5.59" "28.12" "6" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "" "Pf00169, Pf00788" "54518" "ENSG00000077420" "APBB1IP" "hsa:54518; Q7Z5R6; Q8IWS8; Q8IYL7; Q8IZZ7" "TYROBP causal network in microglia" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins" "11" "0" "1.000" "0.937" "0.884" "0.987" "1.043" "0.907" "1.023" "0.998" "0.939" "1233.5" "1233.0" "1155.3" "1090.0" "1217.4" "1286.1" "1119.1" "1261.3" "1231.1" "1158.8" "" "" "" "" "" "" "" "" "" "" "653.1" "683.6" "661.6" "502.0" "658.7" "715.4" "658.6" "688.5" "690.6" "1158.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4697106387219567458" "False" "High" "IsMasterProtein" "Q6P2E9" "Enhancer of mRNA-decapping protein 4 OS=Homo sapiens OX=9606 GN=EDC4 PE=1 SV=1" "0.000" "False" "20.420" "5" "7" "7" "7" "1401" "151.6" "5.86" "18.60" "7" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf16529, Pf21289" "23644" "ENSG00000038358" "EDC4" "A6NGM1; A8K4T4; hsa:23644; Q13025; Q13826; Q6P2E9; Q6ZR12; Q7Z6H7" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "0.969" "0.931" "1.150" "1.002" "0.978" "1.068" "1.032" "1.030" "2.446" "598.2" "579.6" "556.9" "687.6" "599.5" "584.8" "638.8" "617.4" "616.4" "1463.2" "" "" "" "" "" "" "" "" "" "" "316.7" "321.4" "318.9" "316.7" "324.3" "325.3" "376.0" "337.0" "345.8" "1463.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8802670806529502835" "False" "High" "IsMasterProtein" "Q6NYC8" "Phostensin OS=Homo sapiens OX=9606 GN=PPP1R18 PE=1 SV=1" "0.000" "False" "20.392" "11" "7" "9" "7" "613" "67.9" "5.40" "21.59" "7" "" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf13914, Pf13916" "170954" "ENSG00000146112; ENSG00000206485; ENSG00000225060; ENSG00000229998; ENSG00000230341; ENSG00000234000" "PPP1R18" "A2AB01; A2AIB8; A4UBI6; A6NCB7; A8MSS7; B7ZCV7; hsa:170954; Q68CK8; Q6NYC8; Q6ZTV1; Q6ZUJ6; Q8NDQ4; Q8TF52; Q9BRL9" "TYROBP causal network in microglia" "" "1" "0" "1.079" "1.030" "1.126" "1.160" "1.151" "1.417" "1.493" "1.408" "0.637" "721.4" "778.4" "743.3" "812.2" "836.9" "830.2" "1022.2" "1077.1" "1016.0" "459.8" "" "" "" "" "" "" "" "" "" "" "382.0" "431.6" "425.7" "374.0" "452.8" "461.8" "601.6" "588.0" "569.9" "459.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9216601272429108085" "False" "High" "IsMasterProtein" "Q96GX9" "Methylthioribulose-1-phosphate dehydratase OS=Homo sapiens OX=9606 GN=APIP PE=1 SV=1" "0.000" "False" "20.391" "20" "4" "4" "4" "242" "27.1" "7.12" "10.52" "4" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00596" "51074" "ENSG00000149089" "APIP" "A8K9D3; hsa:51074; Q6PJX6; Q8WVU2; Q96GX9; Q96HK2; Q9Y318" "Methionine de novo and salvage pathway" "Regulation of the apoptosome activity; Methionine salvage pathway" "4" "0" "0.980" "1.212" "0.719" "0.886" "1.066" "0.984" "0.939" "1.158" "0.562" "33.1" "32.5" "40.1" "23.8" "29.3" "35.3" "32.6" "31.1" "38.3" "18.6" "" "" "" "" "" "" "" "" "" "" "17.5" "18.0" "23.0" "11.0" "15.9" "19.6" "19.2" "17.0" "21.5" "18.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4905591351439676835" "False" "High" "IsMasterProtein" "P50995" "Annexin A11 OS=Homo sapiens OX=9606 GN=ANXA11 PE=1 SV=1" "0.000" "False" "20.388" "11" "6" "7" "6" "505" "54.4" "7.65" "19.71" "6" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00191" "311" "ENSG00000122359" "ANXA11" "B4DVE7; hsa:311; P50995" "" "" "0" "0" "1.213" "1.179" "1.175" "1.232" "1.306" "1.234" "0.956" "1.203" "4.972" "236.8" "287.4" "279.1" "278.3" "291.7" "309.3" "292.3" "226.3" "284.9" "1177.4" "" "" "" "" "" "" "" "" "" "" "125.4" "159.3" "159.9" "128.2" "157.8" "172.0" "172.0" "123.5" "159.8" "1177.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1845786618234347704" "False" "High" "IsMasterProtein" "P55263" "Adenosine kinase OS=Homo sapiens OX=9606 GN=ADK PE=1 SV=2" "0.000" "False" "20.387" "18" "7" "10" "7" "362" "40.5" "6.70" "30.06" "7" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus" "kinase activity;other molecular function" "Pf00294" "132" "ENSG00000156110" "ADK" "B7Z783; B7Z800; hsa:132; O00741; O00742; P55263; Q16710; Q5JQ10; Q5JQ11; Q9BTN2" "Methionine metabolism leading to sulfur amino acids and related disorders" "Ribavirin ADME; Purine salvage" "3" "0" "0.947" "0.984" "0.933" "0.980" "1.048" "0.972" "1.011" "0.976" "0.544" "1520.6" "1440.0" "1495.7" "1419.2" "1489.6" "1593.5" "1478.1" "1537.7" "1483.4" "827.1" "" "" "" "" "" "" "" "" "" "" "805.1" "798.4" "856.6" "653.6" "806.0" "886.4" "869.9" "839.3" "832.2" "827.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5966605329502245695" "False" "High" "IsMasterProtein" "P10599" "Thioredoxin OS=Homo sapiens OX=9606 GN=TXN PE=1 SV=3" "0.000" "False" "20.379" "30" "3" "19" "3" "105" "11.7" "4.92" "54.83" "3" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00085" "7295" "ENSG00000136810" "TXN" "B1ALW1; hsa:7295; O60744; P10599; Q53X69; Q96KI3; Q9UDG5" "Selenium micronutrient network; Folic acid network; Selenium micronutrient network ; Folic acid network; Selenium micronutrient network; TNF-alpha signaling pathway; Complement system; Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling; TAR syndrome" "Detoxification of Reactive Oxygen Species; Oxidative Stress Induced Senescence; TP53 Regulates Metabolic Genes; Interconversion of nucleotide di- and triphosphates; NFE2L2 regulating anti-oxidant/detoxification enzymes; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Regulation of FOXO transcriptional activity by acetylation; Protein repair" "20" "0" "0.954" "1.017" "0.966" "0.967" "0.907" "0.919" "0.993" "0.885" "0.547" "1617.0" "1543.0" "1644.8" "1562.7" "1563.2" "1467.1" "1485.2" "1605.2" "1431.5" "884.4" "" "" "" "" "" "" "" "" "" "" "856.2" "855.5" "942.0" "719.7" "845.8" "816.1" "874.1" "876.2" "803.0" "884.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7333180136300150104" "False" "High" "IsMasterProtein" "Q96S44" "EKC/KEOPS complex subunit TP53RK OS=Homo sapiens OX=9606 GN=TP53RK PE=1 SV=2" "0.000" "False" "20.370" "23" "5" "6" "5" "253" "28.1" "9.54" "21.79" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf06293" "112858" "ENSG00000172315" "TP53RK" "B3KU44; hsa:112858; Q3T977; Q5JZ01; Q6NZ60; Q96FM7; Q96S44; Q9NQE6" "" "tRNA modification in the nucleus and cytosol; Regulation of TP53 Activity through Phosphorylation" "2" "0" "0.985" "0.993" "0.899" "0.984" "0.999" "0.925" "1.000" "0.961" "0.577" "1161.8" "1144.5" "1153.4" "1044.6" "1143.3" "1161.1" "1074.1" "1161.2" "1116.8" "669.9" "" "" "" "" "" "" "" "" "" "" "615.2" "634.5" "660.5" "481.1" "618.5" "645.8" "632.1" "633.9" "626.5" "669.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5035986382802710418" "False" "High" "IsMasterProtein" "Q9NUB1" "Acetyl-coenzyme A synthetase 2-like, mitochondrial OS=Homo sapiens OX=9606 GN=ACSS1 PE=1 SV=2" "0.000" "False" "20.349" "8" "6" "8" "6" "689" "74.8" "7.11" "24.82" "6" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00501, Pf13193, Pf16177" "84532" "ENSG00000154930" "ACSS1" "B3KXL2; B4DJZ3; D3DW48; F5H6F4; F8W7Y1; hsa:84532; Q5TF42; Q8IV99; Q8N234; Q96JI1; Q96JX6; Q9NU28; Q9NUB1" "Sterol regulatory element-binding proteins (SREBP) signaling; Amino acid metabolism; Statin inhibition of cholesterol production; Familial hyperlipidemia type 4" "Ethanol oxidation" "5" "0" "1.001" "0.995" "0.988" "1.062" "1.115" "0.947" "1.001" "0.949" "0.850" "840.8" "841.8" "836.5" "830.8" "892.7" "937.2" "796.4" "841.7" "797.8" "715.1" "" "" "" "" "" "" "" "" "" "" "445.2" "466.7" "479.1" "382.6" "483.0" "521.3" "468.7" "459.5" "447.5" "715.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8295272483259113664" "False" "High" "IsMasterProtein" "Q9Y333" "U6 snRNA-associated Sm-like protein LSm2 OS=Homo sapiens OX=9606 GN=LSM2 PE=1 SV=1" "0.000" "False" "20.321" "47" "4" "11" "4" "95" "10.8" "6.52" "33.67" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "57819" "ENSG00000172850; ENSG00000204392; ENSG00000224979; ENSG00000225998; ENSG00000231502; ENSG00000236826" "LSM2" "hsa:57819; Q6FGG1; Q9Y333" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "3" "0" "1.002" "0.998" "1.003" "0.943" "1.059" "1.147" "1.067" "1.139" "0.574" "853.6" "855.3" "852.3" "855.9" "804.9" "903.7" "979.1" "910.4" "972.1" "489.9" "" "" "" "" "" "" "" "" "" "" "452.0" "474.2" "488.1" "394.2" "435.5" "502.7" "576.3" "496.9" "545.3" "489.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3428754804967895147" "False" "High" "IsMasterProtein" "O95989" "Diphosphoinositol polyphosphate phosphohydrolase 1 OS=Homo sapiens OX=9606 GN=NUDT3 PE=1 SV=1" "0.000" "False" "20.288" "30" "4" "8" "4" "172" "19.5" "6.34" "22.10" "4" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00293" "11165" "ENSG00000272325" "NUDT3" "B2R8N4; hsa:11165; O95989" "" "Synthesis of pyrophosphates in the cytosol" "1" "0" "0.916" "0.937" "0.929" "0.948" "0.950" "0.917" "1.020" "0.917" "0.568" "532.3" "487.4" "498.8" "494.6" "504.8" "505.7" "488.3" "542.8" "488.2" "302.5" "" "" "" "" "" "" "" "" "" "" "281.9" "270.2" "285.7" "227.8" "273.1" "281.3" "287.4" "296.3" "273.9" "302.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3291285492636401918" "False" "High" "IsMasterProtein" "Q9H974" "Queuine tRNA-ribosyltransferase accessory subunit 2 OS=Homo sapiens OX=9606 GN=QTRT2 PE=1 SV=1" "0.000" "False" "20.246" "14" "4" "4" "4" "415" "46.7" "6.81" "12.35" "4" "RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf01702" "79691" "ENSG00000151576" "QTRT2" "A6NGE9; B7Z472; B7Z5R2; hsa:79691; J3KR78; Q6IA59; Q9H974" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.961" "1.022" "1.010" "1.044" "1.040" "0.954" "0.967" "0.984" "0.805" "449.1" "431.4" "458.9" "453.7" "469.0" "467.0" "428.4" "434.4" "441.8" "361.6" "" "" "" "" "" "" "" "" "" "" "237.8" "239.2" "262.8" "208.9" "253.8" "259.8" "252.1" "237.1" "247.8" "361.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2244898098371361519" "False" "High" "IsMasterProtein" "Q86VS8" "Protein Hook homolog 3 OS=Homo sapiens OX=9606 GN=HOOK3 PE=1 SV=2" "0.000" "False" "20.227" "8" "7" "9" "7" "718" "83.1" "5.17" "22.00" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf05622, Pf19047" "84376" "ENSG00000168172" "HOOK3" "D3DSY8; hsa:84376; Q86VS8; Q8NBH0; Q9BY13" "" "" "0" "0" "1.148" "1.001" "1.201" "1.073" "1.090" "1.066" "0.946" "1.035" "1.561" "181.9" "208.8" "182.1" "218.4" "195.2" "198.2" "193.8" "172.1" "188.2" "283.9" "" "" "" "" "" "" "" "" "" "" "96.3" "115.8" "104.3" "100.6" "105.6" "110.2" "114.1" "94.0" "105.6" "283.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9134021061211319467" "False" "High" "IsMasterProtein" "Q9HA77" "Probable cysteine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=CARS2 PE=1 SV=1" "0.000" "False" "20.206" "7" "4" "5" "4" "564" "62.2" "8.34" "18.79" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01406" "79587" "ENSG00000134905" "CARS2" "hsa:79587; Q8NI84; Q96IV4; Q9HA77" "" "Mitochondrial tRNA aminoacylation" "1" "0" "0.937" "0.937" "0.885" "0.955" "1.035" "0.883" "0.982" "0.984" "0.519" "1022.8" "958.8" "958.3" "905.3" "977.2" "1058.5" "902.9" "1004.5" "1006.1" "531.3" "" "" "" "" "" "" "" "" "" "" "541.6" "531.6" "548.8" "416.9" "528.7" "588.8" "531.4" "548.3" "564.4" "531.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7481599324901596636" "False" "High" "IsMasterProtein" "O75391" "Sperm-associated antigen 7 OS=Homo sapiens OX=9606 GN=SPAG7 PE=1 SV=2" "0.000" "False" "20.178" "20" "3" "3" "3" "227" "26.0" "7.91" "13.75" "3" "" "nucleus" "nucleic acid binding activity" "Pf01424" "9552" "ENSG00000091640" "SPAG7" "hsa:9552; O75391; Q96EU5" "" "" "0" "0" "0.928" "1.077" "1.025" "1.069" "0.963" "0.945" "1.088" "1.055" "0.559" "355.3" "329.6" "382.6" "364.1" "379.7" "342.1" "335.8" "386.7" "374.7" "198.7" "" "" "" "" "" "" "" "" "" "" "188.1" "182.7" "219.1" "167.7" "205.4" "190.3" "197.6" "211.1" "210.2" "198.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-15854148761745197" "False" "High" "IsMasterProtein" "Q6IN85" "Serine/threonine-protein phosphatase 4 regulatory subunit 3A OS=Homo sapiens OX=9606 GN=PPP4R3A PE=1 SV=1" "0.000" "False" "20.159" "8" "6" "8" "4" "833" "95.3" "4.94" "15.77" "6" "stress response" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf04802" "55671" "ENSG00000100796" "PPP4R3A" "hsa:55671; Q69YK6; Q6IN85; Q86U23; Q86YI7; Q8IVG1; Q9H3F1; Q9H7U8; Q9NV01; Q9NWP1" "16p11.2 proximal deletion syndrome" "" "1" "1" "1.020" "1.029" "1.147" "1.044" "1.064" "1.038" "1.008" "1.051" "1.274" "469.1" "478.4" "482.7" "537.9" "489.6" "499.0" "486.7" "472.8" "493.0" "597.4" "" "" "" "" "" "" "" "" "" "" "248.4" "265.2" "276.5" "247.7" "264.9" "277.5" "286.4" "258.1" "276.5" "597.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8625862126903742140" "False" "High" "IsMasterProtein" "P48556" "26S proteasome non-ATPase regulatory subunit 8 OS=Homo sapiens OX=9606 GN=PSMD8 PE=1 SV=2" "0.000" "False" "20.152" "16" "7" "8" "7" "350" "39.6" "9.70" "23.96" "7" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf10075" "5714" "ENSG00000099341" "PSMD8" "B4DX18; hsa:5714; P48556; Q6P1L7" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "1.012" "0.991" "0.973" "1.013" "1.061" "0.973" "0.933" "0.897" "0.650" "1245.3" "1259.9" "1234.4" "1211.2" "1260.9" "1321.8" "1212.0" "1161.4" "1116.9" "809.2" "" "" "" "" "" "" "" "" "" "" "659.4" "698.5" "707.0" "557.8" "682.2" "735.2" "713.3" "634.0" "626.5" "809.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7697340015663074004" "False" "High" "IsMasterProtein" "P56211" "cAMP-regulated phosphoprotein 19 OS=Homo sapiens OX=9606 GN=ARPP19 PE=1 SV=2" "0.000" "False" "20.151" "33" "3" "14" "2" "112" "12.3" "9.09" "41.18" "3" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf04667" "10776" "ENSG00000128989" "ARPP19" "B2R497; hsa:10776; P56211; Q6IAM2; Q86TA6; Q9UD70" "" "MASTL Facilitates Mitotic Progression" "1" "0" "1.016" "1.182" "1.016" "1.119" "0.904" "1.079" "0.969" "0.746" "0.571" "71.8" "73.0" "84.9" "73.0" "80.4" "64.9" "77.5" "69.6" "53.6" "41.0" "" "" "" "" "" "" "" "" "" "" "38.0" "40.5" "48.6" "33.6" "43.5" "36.1" "45.6" "38.0" "30.1" "41.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5077095867447308247" "False" "High" "IsMasterProtein" "Q9BY77" "Polymerase delta-interacting protein 3 OS=Homo sapiens OX=9606 GN=POLDIP3 PE=1 SV=2" "0.000" "False" "20.133" "14" "5" "7" "5" "421" "46.1" "9.99" "21.36" "5" "other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "84271" "ENSG00000100227" "POLDIP3" "A8K6F8; A8K6V9; hsa:84271; Q009A7; Q5H972; Q6PGN6; Q7Z6Z0; Q9BY77; Q9NSP5; Q9NSP6" "" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "3" "0" "0.995" "0.953" "0.985" "0.977" "0.965" "0.953" "0.888" "0.971" "0.656" "291.4" "290.1" "277.6" "286.9" "284.6" "281.2" "277.8" "258.8" "283.0" "191.3" "" "" "" "" "" "" "" "" "" "" "154.3" "160.9" "159.0" "132.1" "154.0" "156.4" "163.5" "141.3" "158.7" "191.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5981355964815445657" "False" "High" "IsMasterProtein" "P35611" "Alpha-adducin OS=Homo sapiens OX=9606 GN=ADD1 PE=1 SV=2" "0.000" "False" "20.108" "5" "4" "5" "4" "737" "80.9" "5.83" "17.51" "4" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00596" "118" "ENSG00000087274" "ADD1" "A2A3N8; A2A3P0; B4DI79; D3DVR3; D3DVR4; D3DVR5; hsa:118; P35611; Q13734; Q14729; Q16156; Q86XM2; Q9UJB6" "" "XBP1(S) activates chaperone genes; Caspase-mediated cleavage of cytoskeletal proteins; Miscellaneous transport and binding events" "3" "0" "0.968" "0.981" "0.960" "0.971" "0.985" "0.965" "1.055" "1.014" "0.557" "1155.1" "1117.8" "1133.0" "1109.1" "1121.4" "1137.8" "1114.7" "1218.2" "1171.1" "643.0" "" "" "" "" "" "" "" "" "" "" "611.6" "619.7" "648.9" "510.8" "606.7" "632.9" "656.0" "665.0" "657.0" "643.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7811403610276720073" "False" "High" "IsMasterProtein" "Q99543" "DnaJ homolog subfamily C member 2 OS=Homo sapiens OX=9606 GN=DNAJC2 PE=1 SV=4" "0.000" "False" "20.102" "9" "6" "6" "6" "621" "72.0" "8.70" "17.39" "6" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "translation activity;other molecular function" "Pf00226, Pf00249, Pf16717" "27000" "ENSG00000105821" "DNAJC2" "A4VCI0; hsa:27000; Q99543; Q9BVX1" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "0.970" "0.956" "1.128" "0.996" "0.899" "1.143" "0.761" "1.029" "3.730" "243.0" "235.7" "232.3" "274.2" "242.0" "218.5" "277.7" "184.9" "250.0" "906.6" "" "" "" "" "" "" "" "" "" "" "128.7" "130.7" "133.1" "126.3" "130.9" "121.6" "163.5" "100.9" "140.3" "906.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8740518017781001578" "False" "High" "IsMasterProtein" "Q8WW12" "PEST proteolytic signal-containing nuclear protein OS=Homo sapiens OX=9606 GN=PCNP PE=1 SV=2" "0.000" "False" "20.073" "26" "4" "6" "4" "178" "18.9" "7.49" "18.11" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "nucleus" "" "Pf15473" "57092" "ENSG00000081154" "PCNP" "B2RBE7; D3DN52; hsa:57092; Q53GF3; Q6AI44; Q8WW12; Q96CU3; Q9NS81" "" "" "0" "0" "0.955" "1.061" "0.958" "0.964" "0.922" "0.939" "1.125" "1.067" "0.449" "933.2" "890.9" "989.8" "894.2" "899.7" "859.9" "876.4" "1050.1" "995.8" "419.2" "" "" "" "" "" "" "" "" "" "" "494.1" "493.9" "566.8" "411.8" "486.7" "478.3" "515.8" "573.2" "558.6" "419.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4682343242687865588" "False" "High" "IsMasterProtein" "O43818" "U3 small nucleolar RNA-interacting protein 2 OS=Homo sapiens OX=9606 GN=RRP9 PE=1 SV=1" "0.000" "False" "20.069" "11" "6" "9" "6" "475" "51.8" "7.85" "26.71" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00400" "9136" "ENSG00000114767" "RRP9" "B2R996; hsa:9136; O43818; Q8IZ30" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "0.999" "1.005" "1.017" "1.093" "1.023" "1.183" "1.084" "1.095" "0.485" "694.0" "693.6" "697.3" "705.6" "758.2" "710.1" "820.6" "752.4" "759.9" "336.8" "" "" "" "" "" "" "" "" "" "" "367.5" "384.5" "399.3" "324.9" "410.2" "395.0" "483.0" "410.7" "426.3" "336.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7478524853152137733" "False" "High" "IsMasterProtein" "P43487" "Ran-specific GTPase-activating protein OS=Homo sapiens OX=9606 GN=RANBP1 PE=1 SV=1" "0.000" "False" "20.055" "22" "5" "12" "5" "201" "23.3" "5.29" "33.73" "5" "transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00638" "5902" "ENSG00000099901" "RANBP1" "hsa:5902; P43487; Q53EY3" "22q11.2 copy number variation syndrome" "Rev-mediated nuclear export of HIV RNA" "2" "0" "0.908" "1.028" "0.977" "0.856" "0.816" "0.892" "0.887" "0.813" "0.779" "1860.7" "1688.9" "1913.4" "1817.0" "1592.6" "1518.6" "1660.6" "1650.2" "1513.2" "1449.0" "" "" "" "" "" "" "" "" "" "" "985.2" "936.4" "1095.8" "836.8" "861.7" "844.7" "977.3" "900.8" "848.9" "1449.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-476306151852591039" "False" "High" "IsMasterProtein" "Q15102" "Platelet-activating factor acetylhydrolase IB subunit alpha1 OS=Homo sapiens OX=9606 GN=PAFAH1B3 PE=1 SV=1" "0.000" "False" "20.033" "25" "6" "13" "6" "231" "25.7" "6.84" "34.13" "6" "other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13472" "5050" "ENSG00000079462" "PAFAH1B3" "hsa:5050; Q15102; Q53X88" "PAFAH1B1 copy number variation" "COPI-independent Golgi-to-ER retrograde traffic" "2" "0" "1.044" "0.966" "1.173" "1.067" "1.031" "0.989" "0.978" "0.943" "1.465" "485.2" "506.7" "469.0" "569.2" "517.5" "500.2" "479.9" "474.3" "457.5" "711.0" "" "" "" "" "" "" "" "" "" "" "256.9" "280.9" "268.6" "262.1" "280.0" "278.2" "282.4" "258.9" "256.6" "711.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2591568921065242388" "False" "High" "IsMasterProtein" "Q8NB90" "ATPase family gene 2 protein homolog A OS=Homo sapiens OX=9606 GN=AFG2A PE=1 SV=3" "0.000" "False" "20.017" "6" "4" "4" "4" "893" "97.8" "5.66" "13.95" "4" "developmental processes;other biological processes" "cytoskeleton;mitochondrion;other cell component" "other molecular function" "Pf00004, Pf17862" "166378" "ENSG00000145375" "AFG2A" "C9JT97; hsa:166378; Q86XW1; Q8NB90; Q8NI20; Q8TDL7" "" "" "0" "0" "0.996" "1.063" "0.931" "0.824" "1.093" "1.041" "0.819" "1.046" "0.686" "54.4" "54.2" "57.8" "50.6" "44.8" "59.4" "56.6" "44.6" "56.9" "37.3" "" "" "" "" "" "" "" "" "" "" "28.8" "30.0" "33.1" "23.3" "24.2" "33.1" "33.3" "24.3" "31.9" "37.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1084161266970488512" "False" "High" "IsMasterProtein" "Q04206" "Transcription factor p65 OS=Homo sapiens OX=9606 GN=RELA PE=1 SV=2" "0.000" "False" "19.981" "9" "5" "6" "5" "551" "60.2" "5.68" "18.34" "5" "cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "5970" "ENSG00000173039" "RELA" "hsa:5970; Q04206; Q6GTV1; Q6SLK1" "Androgen receptor signaling pathway; Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Aryl hydrocarbon receptor pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Selenium metabolism and selenoproteins; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; VEGFA-VEGFR2 signaling; ApoE and miR-146 in inflammation and atherosclerosis; Chemokine signaling pathway; IL-4 signaling pathway; NO/cGMP/PKG mediated neuroprotection; Fibrin complement receptor 3 signaling pathway; PI3K/AKT/mTOR - vitamin D3 signaling; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Nonalcoholic fatty liver disease; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; CAMKK2 pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Neuroinflammation; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; Opioid receptor pathways; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; Osteoarthritic chondrocyte hypertrophy; 15q11q13 copy number variation; T-cell receptor signaling pathway; Toll-like receptor signaling pathway" "Senescence-Associated Secretory Phenotype (SASP); FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Dectin-1 mediated noncanonical NF-kB signaling; Transcriptional regulation of white adipocyte differentiation; Transcriptional Regulation by VENTX; PKMTs methylate histone lysines; RIP-mediated NFkB activation via ZBP1; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; SARS-CoV-1 activates/modulates innate immune responses; Regulation of NFE2L2 gene expression; CD209 (DC-SIGN) signaling; Interleukin-1 processing; CLEC7A/inflammasome pathway; Regulated proteolysis of p75NTR; SUMOylation of immune response proteins; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "101" "0" "1.021" "1.047" "1.120" "1.071" "1.000" "1.060" "0.750" "1.056" "4.114" "670.3" "684.6" "701.6" "750.7" "717.7" "670.5" "710.6" "502.8" "708.0" "2757.5" "" "" "" "" "" "" "" "" "" "" "354.9" "379.6" "401.8" "345.7" "388.3" "372.9" "418.2" "274.5" "397.2" "2757.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8217852517475646555" "False" "High" "IsMasterProtein" "Q9H3U1" "Protein unc-45 homolog A OS=Homo sapiens OX=9606 GN=UNC45A PE=1 SV=1" "0.000" "False" "19.974" "6" "5" "6" "5" "944" "103.0" "6.07" "10.19" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf11701, Pf13181" "55898" "ENSG00000140553" "UNC45A" "A8K6F7; hsa:55898; Q7L3Y6; Q9H3U1; Q9H3U8; Q9NSE8; Q9NSE9" "" "" "0" "0" "1.064" "1.008" "0.959" "1.017" "0.944" "1.041" "0.421" "0.922" "5.768" "161.9" "172.4" "163.2" "155.2" "164.8" "152.8" "168.6" "68.2" "149.4" "934.1" "" "" "" "" "" "" "" "" "" "" "85.8" "95.6" "93.4" "71.5" "89.1" "85.0" "99.2" "37.2" "83.8" "934.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3688625229951110619" "False" "High" "IsMasterProtein" "Cont_P02538" "Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3" "0.000" "True" "19.930" "8" "6" "8" "1" "564" "60.0" "8.00" "23.22" "6" "cell organization and biogenesis;stress response;other biological processes" "cytosol;cytoskeleton" "bone, tooth or skin structural activity;cytoskeletal activity" "Pf00038, Pf16208" "3853" "ENSG00000205420" "KRT6A" "A0A0S2Z428; A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4" "Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes" "Formation of the cornified envelope" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8333902830713908614" "False" "High" "IsMasterProtein" "P05388" "Large ribosomal subunit protein uL10 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1" "0.000" "False" "19.895" "20" "5" "9" "5" "317" "34.3" "5.97" "22.71" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00428, Pf00466, Pf17777" "6175" "ENSG00000089157" "RPLP0" "hsa:6175; P05388; Q3B7A4; Q9BVK4" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "1.055" "1.112" "1.089" "1.122" "1.125" "1.329" "1.376" "1.236" "0.662" "256.9" "270.9" "285.7" "279.6" "288.2" "288.9" "341.4" "353.4" "317.4" "170.0" "" "" "" "" "" "" "" "" "" "" "136.0" "150.2" "163.6" "128.8" "155.9" "160.7" "200.9" "192.9" "178.1" "170.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1732426368668540463" "False" "High" "IsMasterProtein" "Q8N9N8" "Probable RNA-binding protein EIF1AD OS=Homo sapiens OX=9606 GN=EIF1AD PE=1 SV=1" "0.000" "False" "19.889" "29" "3" "3" "3" "165" "19.0" "5.21" "11.80" "3" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01176" "84285" "ENSG00000175376" "EIF1AD" "B2R4N5; hsa:84285; Q8N9N8; Q9BSC1" "" "" "0" "0" "1.047" "0.970" "1.072" "0.898" "1.040" "1.098" "0.887" "0.912" "0.700" "139.9" "146.5" "135.6" "150.0" "125.6" "145.4" "153.6" "124.1" "127.6" "97.9" "" "" "" "" "" "" "" "" "" "" "74.1" "81.2" "77.7" "69.1" "67.9" "80.9" "90.4" "67.7" "71.6" "97.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2765155610572928931" "False" "High" "IsMasterProtein" "Q8IZ73" "Pseudouridylate synthase RPUSD2 OS=Homo sapiens OX=9606 GN=RPUSD2 PE=1 SV=2" "0.000" "False" "19.867" "8" "4" "4" "4" "545" "61.3" "7.17" "11.81" "4" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf00849" "27079" "ENSG00000166133" "RPUSD2" "B4DDD1; hsa:27079; Q7L989; Q8IZ73; Q92939; Q96IA7; Q96N50" "" "" "0" "0" "0.974" "0.973" "0.916" "1.009" "1.025" "1.036" "0.896" "0.989" "0.679" "375.8" "365.9" "365.7" "344.1" "379.2" "385.2" "389.4" "336.8" "371.6" "255.3" "" "" "" "" "" "" "" "" "" "" "199.0" "202.9" "209.4" "158.5" "205.1" "214.2" "229.2" "183.8" "208.4" "255.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2064398730154585057" "False" "High" "IsMasterProtein" "Q15061" "WD repeat-containing protein 43 OS=Homo sapiens OX=9606 GN=WDR43 PE=1 SV=3" "0.000" "False" "19.831" "7" "5" "8" "5" "677" "74.8" "5.57" "25.75" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf04003" "23160" "ENSG00000163811" "WDR43" "hsa:23160; Q15061; Q15395; Q92577" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.064" "1.056" "1.011" "0.992" "0.911" "0.975" "1.104" "1.035" "0.287" "1673.6" "1780.0" "1767.1" "1691.8" "1660.2" "1525.2" "1631.3" "1847.1" "1731.9" "480.2" "" "" "" "" "" "" "" "" "" "" "886.2" "986.9" "1012.0" "779.1" "898.2" "848.4" "960.1" "1008.3" "971.6" "480.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1199984255511246690" "False" "High" "IsMasterProtein" "P85037" "Forkhead box protein K1 OS=Homo sapiens OX=9606 GN=FOXK1 PE=1 SV=1" "0.000" "False" "19.819" "13" "9" "12" "9" "733" "75.4" "9.32" "27.36" "9" "other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250, Pf00498" "221937" "ENSG00000164916" "FOXK1" "hsa:221937; P85037" "" "UCH proteinases" "1" "0" "1.062" "1.003" "1.089" "1.034" "1.028" "0.961" "0.848" "0.903" "1.732" "1049.7" "1114.8" "1052.8" "1143.7" "1085.2" "1079.1" "1009.2" "889.8" "948.3" "1817.7" "" "" "" "" "" "" "" "" "" "" "555.8" "618.1" "602.9" "526.7" "587.1" "600.3" "594.0" "485.7" "532.0" "1817.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8285905538601848760" "False" "High" "IsMasterProtein" "Q9H0E9" "Bromodomain-containing protein 8 OS=Homo sapiens OX=9606 GN=BRD8 PE=1 SV=2" "0.000" "False" "19.810" "5" "7" "8" "7" "1235" "135.3" "4.60" "19.38" "7" "cell organization and biogenesis;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00439" "10902" "ENSG00000112983" "BRD8" "hsa:10902; O43178; Q15355; Q58AB0; Q59GN0; Q969M9; Q9H0E9" "" "HATs acetylate histones" "1" "0" "0.957" "0.987" "1.055" "0.987" "0.965" "1.155" "1.078" "1.114" "1.025" "394.3" "377.5" "389.1" "416.2" "389.3" "380.5" "455.4" "425.2" "439.3" "404.3" "" "" "" "" "" "" "" "" "" "" "208.8" "209.3" "222.8" "191.7" "210.6" "211.7" "268.0" "232.1" "246.4" "404.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1468233501590493710" "False" "High" "IsMasterProtein" "O60832" "H/ACA ribonucleoprotein complex subunit DKC1 OS=Homo sapiens OX=9606 GN=DKC1 PE=1 SV=3" "0.000" "False" "19.794" "13" "6" "7" "6" "514" "57.6" "9.42" "21.20" "6" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01472, Pf01509, Pf08068, Pf16198" "1736" "ENSG00000130826" "DKC1" "F5BSB3; hsa:1736; O43845; O60832; Q96G67; Q9Y505" "" "rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase" "2" "0" "0.906" "0.928" "1.170" "1.010" "1.024" "1.759" "1.856" "1.622" "0.684" "657.5" "595.7" "610.2" "768.9" "664.0" "673.3" "1156.7" "1220.5" "1066.4" "449.6" "" "" "" "" "" "" "" "" "" "" "348.1" "330.3" "349.5" "354.1" "359.3" "374.5" "680.8" "666.2" "598.2" "449.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "906200433272310872" "False" "High" "IsMasterProtein" "Q8NBS9" "Thioredoxin domain-containing protein 5 OS=Homo sapiens OX=9606 GN=TXNDC5 PE=1 SV=2" "0.000" "False" "19.760" "11" "5" "10" "5" "432" "47.6" "5.97" "20.68" "5" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00085" "81567" "ENSG00000239264" "TXNDC5" "B2RDM2; hsa:81567; Q5TCQ0; Q8NBS9; Q8ND33; Q8TCT2; Q9BVH9" "VEGFA-VEGFR2 signaling" "Neutrophil degranulation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis" "4" "0" "0.963" "0.907" "0.822" "0.893" "0.918" "0.903" "1.020" "1.061" "0.611" "855.2" "823.2" "775.8" "702.8" "764.1" "785.1" "772.3" "872.5" "907.4" "522.7" "" "" "" "" "" "" "" "" "" "" "452.8" "456.4" "444.3" "323.7" "413.4" "436.7" "454.5" "476.2" "509.1" "522.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5104868076877432039" "False" "High" "IsMasterProtein" "Q9HC38" "Glyoxalase domain-containing protein 4 OS=Homo sapiens OX=9606 GN=GLOD4 PE=1 SV=1" "0.000" "False" "19.719" "13" "4" "8" "4" "313" "34.8" "5.60" "23.86" "4" "" "mitochondrion" "" "Pf21207, Pf21701" "51031" "ENSG00000167699" "GLOD4" "D3DTG9; D3DTH1; hsa:51031; Q96B89; Q9H3J8; Q9HC37; Q9HC38; Q9NVN1" "" "" "0" "0" "1.027" "1.043" "1.097" "1.041" "1.079" "1.084" "0.941" "0.944" "1.546" "395.3" "406.1" "412.4" "433.8" "411.5" "426.4" "428.4" "372.2" "373.3" "611.3" "" "" "" "" "" "" "" "" "" "" "209.3" "225.2" "236.2" "199.8" "222.6" "237.2" "252.1" "203.2" "209.4" "611.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4088167174397650062" "False" "High" "IsMasterProtein" "Q9BV20" "Methylthioribose-1-phosphate isomerase OS=Homo sapiens OX=9606 GN=MRI1 PE=1 SV=1" "0.000" "False" "19.658" "12" "5" "9" "5" "369" "39.1" "6.30" "22.84" "5" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01008" "84245" "ENSG00000037757" "MRI1" "hsa:84245; Q8NDC9; Q9BV20" "Methionine de novo and salvage pathway" "Methionine salvage pathway" "2" "0" "1.003" "0.991" "1.005" "0.982" "0.988" "0.982" "0.974" "0.925" "0.617" "1144.6" "1147.9" "1133.8" "1150.8" "1123.8" "1131.2" "1124.2" "1114.5" "1059.0" "706.1" "" "" "" "" "" "" "" "" "" "" "606.1" "636.4" "649.3" "530.0" "608.0" "629.2" "661.6" "608.3" "594.1" "706.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7162742285351111146" "False" "High" "IsMasterProtein" "Q13330" "Metastasis-associated protein MTA1 OS=Homo sapiens OX=9606 GN=MTA1 PE=1 SV=2" "0.000" "False" "19.639" "7" "5" "9" "4" "715" "80.7" "9.26" "23.27" "5" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf00320, Pf01426, Pf01448, Pf17226" "9112" "ENSG00000182979" "MTA1" "A5PLK4; hsa:9112; Q13330; Q86SW2; Q8NFI8; Q96GI8" "Effect of progerin on genes involved in progeria; TAR syndrome" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; SUMOylation of transcription factors" "8" "0" "1.009" "1.026" "1.196" "1.169" "1.120" "1.252" "1.287" "1.318" "0.861" "126.4" "127.5" "129.8" "151.2" "147.8" "141.6" "158.3" "162.8" "166.7" "108.9" "" "" "" "" "" "" "" "" "" "" "66.9" "70.7" "74.3" "69.6" "79.9" "78.8" "93.2" "88.8" "93.5" "108.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4027474892696141167" "False" "High" "IsMasterProtein" "Q9BZI7" "Regulator of nonsense transcripts 3B OS=Homo sapiens OX=9606 GN=UPF3B PE=1 SV=1" "0.000" "False" "19.594" "12" "5" "5" "5" "483" "57.7" "9.48" "15.01" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf03467" "65109" "ENSG00000125351" "UPF3B" "D3DWI3; D3DWI4; hsa:65109; Q0VAK8; Q9BZI7; Q9H1J0" "" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing" "6" "0" "1.008" "1.155" "1.107" "1.014" "1.040" "1.017" "1.075" "1.076" "1.164" "551.3" "555.6" "636.9" "610.3" "559.2" "573.5" "560.6" "592.7" "593.1" "641.8" "" "" "" "" "" "" "" "" "" "" "291.9" "308.1" "364.7" "281.1" "302.5" "319.0" "329.9" "323.5" "332.7" "641.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3546401136209877532" "False" "High" "IsMasterProtein" "O75821" "Eukaryotic translation initiation factor 3 subunit G OS=Homo sapiens OX=9606 GN=EIF3G PE=1 SV=2" "0.000" "False" "19.585" "14" "4" "7" "4" "320" "35.6" "6.13" "21.36" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00076, Pf12353" "8666" "ENSG00000130811" "EIF3G" "hsa:8666; O14801; O75821; Q969U5" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "0" "1.071" "0.948" "1.105" "1.063" "0.963" "1.270" "1.256" "1.223" "1.115" "721.4" "772.5" "683.6" "796.8" "766.6" "694.5" "916.5" "905.8" "882.1" "804.6" "" "" "" "" "" "" "" "" "" "" "382.0" "428.3" "391.5" "367.0" "414.8" "386.3" "539.4" "494.4" "494.8" "804.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2170038667873591835" "False" "High" "IsMasterProtein" "O15027" "Protein transport protein Sec16A OS=Homo sapiens OX=9606 GN=SEC16A PE=1 SV=4" "0.000" "False" "19.581" "3" "6" "7" "6" "2357" "251.7" "5.80" "18.50" "6" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "" "Pf12931, Pf12932" "9919" "ENSG00000148396" "SEC16A" "A1YCA4; hsa:9919; J3KNL6; O15027; Q4G0D7; Q5SXP0; Q5SXP1; Q8N347; Q96HP1" "" "COPII-mediated vesicle transport" "1" "0" "0.981" "1.001" "1.088" "1.073" "1.030" "1.348" "1.426" "1.296" "1.741" "479.8" "470.7" "480.4" "521.9" "514.7" "494.4" "646.5" "684.2" "621.6" "835.4" "" "" "" "" "" "" "" "" "" "" "254.0" "261.0" "275.1" "240.4" "278.5" "275.0" "380.5" "373.5" "348.7" "835.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7462981975688921114" "False" "High" "IsMasterProtein" "Q7Z2T5" "TRMT1-like protein OS=Homo sapiens OX=9606 GN=TRMT1L PE=1 SV=2" "0.000" "False" "19.566" "7" "5" "5" "5" "733" "81.7" "7.88" "14.09" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf02005" "81627" "ENSG00000121486" "TRMT1L" "hsa:81627; Q5TEN0; Q6ZMX0; Q7Z2T5; Q8IWH5; Q8NC68; Q9BZQ1" "" "" "0" "0" "1.034" "0.983" "1.242" "0.951" "0.957" "0.861" "0.788" "0.780" "1.539" "362.4" "374.7" "356.1" "450.0" "344.5" "346.6" "312.1" "285.5" "282.7" "557.6" "" "" "" "" "" "" "" "" "" "" "191.9" "207.7" "203.9" "207.2" "186.4" "192.8" "183.7" "155.9" "158.6" "557.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8165870367093882655" "False" "High" "IsMasterProtein" "Q86TI2" "Dipeptidyl peptidase 9 OS=Homo sapiens OX=9606 GN=DPP9 PE=1 SV=3" "0.000" "False" "19.555" "7" "6" "7" "6" "863" "98.2" "6.46" "16.68" "6" "protein metabolism;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00326, Pf00930, Pf19520" "91039" "ENSG00000142002" "DPP9" "hsa:91039; O75273; O75868; Q1ZZB8; Q6AI37; Q6UAL0; Q6ZMT2; Q6ZNJ5; Q86TI2; Q8N2J7; Q8N3F5; Q8WXD8; Q96NT8; Q9BVR3" "Lung fibrosis" "" "1" "0" "1.027" "0.906" "1.013" "1.087" "1.128" "0.951" "0.923" "0.894" "1.318" "317.6" "326.1" "287.9" "321.9" "345.4" "358.4" "302.1" "293.1" "284.1" "418.7" "" "" "" "" "" "" "" "" "" "" "168.2" "180.8" "164.9" "148.2" "186.9" "199.4" "177.8" "160.0" "159.4" "418.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2304396321486536577" "False" "High" "IsMasterProtein" "Q8IXQ4" "GPALPP motifs-containing protein 1 OS=Homo sapiens OX=9606 GN=GPALPP1 PE=1 SV=1" "0.000" "False" "19.550" "18" "6" "6" "6" "340" "38.1" "5.41" "16.68" "6" "" "" "" "Pf12572" "55425" "ENSG00000133114" "GPALPP1" "A8K8X8; hsa:55425; Q05BX8; Q05D87; Q5T3Z3; Q5T3Z5; Q8IXQ4; Q9C0F9; Q9H2R0; Q9P0W6" "" "" "0" "0" "0.942" "0.987" "1.084" "0.901" "0.876" "0.911" "1.068" "0.979" "0.371" "663.7" "625.2" "655.1" "719.6" "598.0" "581.2" "604.5" "708.5" "649.9" "246.1" "" "" "" "" "" "" "" "" "" "" "351.4" "346.6" "375.2" "331.4" "323.6" "323.3" "355.7" "386.8" "364.6" "246.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5702774175857427246" "False" "High" "IsMasterProtein" "Q02078" "Myocyte-specific enhancer factor 2A OS=Homo sapiens OX=9606 GN=MEF2A PE=1 SV=1" "0.000" "False" "19.537" "16" "6" "6" "4" "507" "54.8" "7.91" "15.54" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319, Pf12347" "4205" "ENSG00000068305" "MEF2A" "B4DFQ7; F6XG23; hsa:4205; O43814; Q02078; Q14223; Q14224; Q59GX4; Q7Z6C9; Q96D14" "Energy metabolism; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac hypertrophic response; TGF-beta signaling pathway; EGF/EGFR signaling pathway; IL-18 signaling pathway; 2q37 copy number variation syndrome" "Myogenesis; ERK/MAPK targets" "13" "0" "1.134" "0.998" "1.382" "1.189" "1.372" "1.209" "1.411" "1.409" "0.989" "153.5" "174.1" "153.2" "212.2" "182.5" "210.6" "185.6" "216.6" "216.4" "151.9" "" "" "" "" "" "" "" "" "" "" "81.3" "96.5" "87.8" "97.7" "98.7" "117.1" "109.2" "118.2" "121.4" "151.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "875070389354990237" "False" "High" "IsMasterProtein" "O00273" "DNA fragmentation factor subunit alpha OS=Homo sapiens OX=9606 GN=DFFA PE=1 SV=1" "0.000" "False" "19.511" "15" "5" "6" "5" "331" "36.5" "4.79" "17.84" "5" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02017, Pf09033" "1676" "ENSG00000160049" "DFFA" "hsa:1676; O00273; Q5T6G5; Q5T6G6; Q96I97; Q9Y6C6" "Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis" "Apoptosis induced DNA fragmentation" "4" "0" "1.066" "1.082" "1.177" "1.047" "1.019" "1.237" "1.250" "1.217" "0.740" "576.0" "613.9" "623.3" "677.6" "602.9" "587.1" "712.7" "719.9" "701.2" "426.4" "" "" "" "" "" "" "" "" "" "" "305.0" "340.4" "356.9" "312.1" "326.2" "326.6" "419.4" "392.9" "393.4" "426.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6066576864868279087" "False" "High" "IsMasterProtein" "Q9Y263" "Phospholipase A-2-activating protein OS=Homo sapiens OX=9606 GN=PLAA PE=1 SV=2" "0.000" "False" "19.509" "10" "7" "7" "7" "795" "87.1" "6.37" "16.79" "7" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf08324, Pf09070" "9373" "ENSG00000137055" "PLAA" "hsa:9373; Q53EU5; Q5VY33; Q9NUL8; Q9NVE9; Q9UF53; Q9Y263; Q9Y5L1" "" "" "0" "0" "1.264" "1.148" "1.299" "1.207" "1.278" "1.404" "1.046" "1.297" "5.712" "171.8" "217.1" "197.2" "223.1" "207.4" "219.4" "241.2" "179.7" "222.8" "981.1" "" "" "" "" "" "" "" "" "" "" "90.9" "120.4" "112.9" "102.8" "112.2" "122.1" "141.9" "98.1" "125.0" "981.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6137891794897938593" "False" "High" "IsMasterProtein" "Q8NEF9" "Serum response factor-binding protein 1 OS=Homo sapiens OX=9606 GN=SRFBP1 PE=1 SV=1" "0.000" "False" "19.505" "17" "7" "7" "7" "429" "48.6" "9.58" "14.56" "7" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf09073" "153443" "ENSG00000151304" "SRFBP1" "hsa:153443; Q5QFI2; Q8NEF9; Q96AH4; Q96DK2" "" "" "0" "0" "1.037" "1.014" "0.964" "1.020" "0.948" "0.882" "0.992" "1.033" "0.782" "397.1" "411.9" "402.5" "382.9" "405.0" "376.5" "350.1" "393.8" "410.2" "310.7" "" "" "" "" "" "" "" "" "" "" "210.3" "228.4" "230.5" "176.4" "219.1" "209.4" "206.0" "215.0" "230.1" "310.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7607180034342260294" "False" "High" "IsMasterProtein" "Q6P179" "Endoplasmic reticulum aminopeptidase 2 OS=Homo sapiens OX=9606 GN=ERAP2 PE=1 SV=2" "0.000" "False" "19.488" "6" "7" "11" "7" "960" "110.4" "6.71" "23.11" "7" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf01433, Pf11838, Pf17900" "64167" "ENSG00000164308" "ERAP2" "hsa:64167; Q6P179; Q7Z5K1; Q8TD32; Q8WVJ4; Q9HBX2" "" "Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "1" "0" "1.024" "1.014" "0.962" "1.066" "1.020" "1.061" "1.118" "0.959" "0.608" "528.7" "541.1" "535.9" "508.8" "563.6" "539.4" "561.0" "591.3" "507.1" "321.4" "" "" "" "" "" "" "" "" "" "" "279.9" "300.0" "306.9" "234.3" "304.9" "300.0" "330.2" "322.7" "284.5" "321.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3574208382527803870" "False" "High" "IsMasterProtein" "Q9Y2X7" "ARF GTPase-activating protein GIT1 OS=Homo sapiens OX=9606 GN=GIT1 PE=1 SV=2" "0.000" "False" "19.476" "7" "6" "7" "4" "761" "84.3" "6.80" "21.30" "6" "transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf01412, Pf08518, Pf12205, Pf12796, Pf16559" "28964" "ENSG00000108262" "GIT1" "B4DGU9; B4DSV3; hsa:28964; Q86SS0; Q9BRJ4; Q9Y2X7" "CAMKK2 pathway; Regulation of actin cytoskeleton" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; CDC42 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Ephrin signaling; Activation of RAC1 downstream of NMDARs" "12" "1" "1.018" "1.048" "1.181" "1.156" "1.150" "1.598" "1.384" "1.635" "3.993" "435.5" "443.2" "456.4" "514.2" "503.3" "500.7" "696.0" "602.5" "712.1" "1738.9" "" "" "" "" "" "" "" "" "" "" "230.6" "245.7" "261.4" "236.8" "272.3" "278.5" "409.6" "328.9" "399.4" "1738.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3353134017530951509" "False" "High" "IsMasterProtein" "Q9Y5K5" "Ubiquitin carboxyl-terminal hydrolase isozyme L5 OS=Homo sapiens OX=9606 GN=UCHL5 PE=1 SV=3" "0.000" "False" "19.424" "15" "5" "7" "5" "329" "37.6" "5.33" "17.29" "5" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01088, Pf18031" "51377" "ENSG00000116750" "UCHL5" "hsa:51377; Q5LJA6; Q5LJA7; Q8TBS4; Q96BJ9; Q9H1W5; Q9P0I3; Q9UQN2; Q9Y5K5" "TGF-beta signaling pathway" "UCH proteinases; Downregulation of TGF-beta receptor signaling" "3" "0" "1.063" "1.117" "1.217" "1.160" "1.102" "1.137" "0.676" "1.186" "5.429" "383.3" "407.5" "428.2" "466.6" "444.6" "422.4" "436.0" "259.0" "454.7" "2081.2" "" "" "" "" "" "" "" "" "" "" "203.0" "225.9" "245.2" "214.9" "240.6" "235.0" "256.6" "141.4" "255.1" "2081.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3391234540397172253" "False" "High" "IsMasterProtein" "Q9H2U1" "ATP-dependent DNA/RNA helicase DHX36 OS=Homo sapiens OX=9606 GN=DHX36 PE=1 SV=2" "0.000" "False" "19.417" "5" "4" "4" "4" "1008" "114.7" "7.68" "8.94" "4" "cell organization and biogenesis;RNA metabolism OR transcription;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "170506" "ENSG00000174953" "DHX36" "B2RB00; hsa:170506; Q70JU3; Q8IYE5; Q9H2U1; Q9P240" "VEGFA-VEGFR2 signaling" "DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "2" "0" "0.974" "0.971" "0.820" "1.088" "1.044" "0.915" "0.862" "0.960" "0.982" "209.6" "204.3" "203.5" "171.9" "228.1" "218.8" "191.8" "180.7" "201.2" "205.8" "" "" "" "" "" "" "" "" "" "" "111.0" "113.2" "116.5" "79.2" "123.4" "121.7" "112.9" "98.7" "112.9" "205.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6667619497174905717" "False" "High" "IsMasterProtein" "Q96MW1" "Coiled-coil domain-containing protein 43 OS=Homo sapiens OX=9606 GN=CCDC43 PE=1 SV=2" "0.000" "False" "19.408" "19" "4" "7" "4" "224" "25.2" "4.92" "22.62" "4" "" "cytosol" "" "" "124808" "ENSG00000180329" "CCDC43" "C9JVK9; hsa:124808; Q96MW1" "" "" "0" "0" "1.084" "1.020" "1.021" "1.054" "0.842" "0.982" "1.063" "0.978" "0.830" "634.6" "687.8" "647.3" "647.8" "669.0" "534.6" "623.5" "674.6" "620.7" "526.8" "" "" "" "" "" "" "" "" "" "" "336.0" "381.4" "370.7" "298.3" "361.9" "297.4" "367.0" "368.2" "348.2" "526.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5840066189523461680" "False" "High" "IsMasterProtein" "P22694" "cAMP-dependent protein kinase catalytic subunit beta OS=Homo sapiens OX=9606 GN=PRKACB PE=1 SV=2" "0.000" "False" "19.406" "14" "4" "5" "2" "351" "40.6" "8.78" "15.89" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5567" "ENSG00000142875" "PRKACB" "B1APG4; B4DKB0; B4E2Q1; hsa:5567; P22694; Q14VH1; Q59GC0; Q5BNE9; Q5BNF0; Q5BNF1; Q5BNF2; Q5BNF3; Q5CZ92; Q5T1K3; Q7Z3M1; Q8IYR5; Q8IZQ0; Q96B09" "AMP-activated protein kinase signaling; Dopamine metabolism; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; G protein signaling pathways; MAPK signaling pathway; Cannabinoid receptor signaling; Chemokine signaling pathway; Lipid metabolism pathway; Ras signaling; Hedgehog signaling pathway; Thermogenesis; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; GPR143 in melanocytes and retinal pigment epithelium cells; Vasopressin-regulated water reabsorption; Cardiomyocyte signaling pathways converging on titin; Calcium regulation in cardiac cells; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "FCGR3A-mediated IL10 synthesis; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Triglyceride catabolism; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; RET signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; CD209 (DC-SIGN) signaling; Rap1 signalling; HDL assembly; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase; ROBO receptors bind AKAP5; PKA-mediated phosphorylation of key metabolic factors" "47" "0" "1.153" "0.944" "1.111" "1.029" "1.126" "1.243" "1.054" "1.118" "1.582" "115.3" "133.0" "108.8" "128.1" "118.6" "129.8" "143.3" "121.5" "128.9" "182.4" "" "" "" "" "" "" "" "" "" "" "61.0" "73.7" "62.3" "59.0" "64.2" "72.2" "84.3" "66.3" "72.3" "182.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-397251386471415027" "False" "High" "IsMasterProtein" "Q9Y3X0" "Coiled-coil domain-containing protein 9 OS=Homo sapiens OX=9606 GN=CCDC9 PE=1 SV=1" "0.000" "False" "19.404" "10" "5" "5" "5" "531" "59.7" "5.40" "15.52" "5" "" "nucleus" "nucleic acid binding activity" "Pf15266" "26093" "ENSG00000105321" "CCDC9" "hsa:26093; Q9Y3X0" "IL-18 signaling pathway" "" "1" "0" "1.028" "0.894" "0.937" "0.950" "0.889" "0.978" "0.873" "0.831" "0.671" "502.6" "516.9" "449.4" "471.2" "477.5" "446.9" "491.4" "438.8" "417.8" "337.4" "" "" "" "" "" "" "" "" "" "" "266.2" "286.6" "257.3" "217.0" "258.3" "248.6" "289.2" "239.5" "234.4" "337.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-824304309308168891" "False" "High" "IsMasterProtein" "Q14005" "Pro-interleukin-16 OS=Homo sapiens OX=9606 GN=IL16 PE=1 SV=4" "0.000" "False" "19.404" "6" "6" "6" "6" "1332" "141.7" "8.06" "14.80" "6" "signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding" "Pf00595" "3603" "ENSG00000172349" "IL16" "A6NM20; A8MU65; B5TY35; B9EGR6; H3BVH5; hsa:3603; Q14005; Q16435; Q6VVE6; Q6ZMQ7; Q9UP18" "" "Other interleukin signaling" "1" "0" "0.954" "0.831" "0.929" "0.837" "0.866" "1.215" "0.943" "0.929" "0.923" "196.2" "187.1" "163.0" "182.2" "164.2" "169.9" "238.4" "185.0" "182.3" "181.1" "" "" "" "" "" "" "" "" "" "" "103.9" "103.7" "93.3" "83.9" "88.8" "94.5" "140.3" "101.0" "102.2" "181.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7827642572833014462" "False" "High" "IsMasterProtein" "P14649" "Myosin light chain 6B OS=Homo sapiens OX=9606 GN=MYL6B PE=1 SV=1" "0.000" "False" "19.394" "28" "6" "6" "5" "208" "22.8" "5.73" "16.67" "6" "other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "" "140465" "ENSG00000196465" "MYL6B" "hsa:140465; P14649" "Ciliary landscape" "Smooth Muscle Contraction" "2" "1" "1.032" "1.017" "1.097" "1.038" "0.997" "1.033" "1.036" "0.927" "0.703" "564.2" "582.4" "573.5" "618.9" "585.4" "562.7" "582.6" "584.7" "522.8" "396.4" "" "" "" "" "" "" "" "" "" "" "298.7" "322.9" "328.4" "285.0" "316.7" "313.0" "342.9" "319.2" "293.3" "396.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5625477449042213507" "False" "High" "IsMasterProtein" "P04179" "Superoxide dismutase [Mn], mitochondrial OS=Homo sapiens OX=9606 GN=SOD2 PE=1 SV=3" "0.000" "False" "19.393" "17" "4" "10" "4" "222" "24.7" "8.25" "32.91" "4" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00081, Pf02777" "6648" "ENSG00000291237" "SOD2" "B2R7R1; B3KUK2; B4DL20; B4E3K9; E1P5A9; P04179; P78434; Q16792; Q5TCM1; Q96EE6; Q9P2Z3" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; VEGFA-VEGFR2 signaling; Oxidative stress response" "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Detoxification of Reactive Oxygen Species; Transcriptional activation of mitochondrial biogenesis; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "10" "0" "1.022" "1.041" "1.005" "1.074" "1.054" "0.966" "1.082" "0.972" "0.624" "607.7" "620.8" "633.0" "610.6" "652.6" "640.4" "587.2" "657.3" "590.5" "379.4" "" "" "" "" "" "" "" "" "" "" "321.8" "344.2" "362.5" "281.2" "353.1" "356.2" "345.6" "358.8" "331.2" "379.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5341813448089902722" "False" "High" "IsMasterProtein" "P16885" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 OS=Homo sapiens OX=9606 GN=PLCG2 PE=1 SV=4" "0.000" "False" "19.388" "6" "7" "7" "7" "1265" "147.8" "6.64" "14.56" "7" "cell-cell signaling;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00017, Pf00018, Pf00168, Pf00387, Pf00388, Pf16457" "5336" "ENSG00000197943" "PLCG2" "D3DUL3; hsa:5336; P16885; Q3ZTS2; Q59H45; Q969T5" "Leptin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; Microglia pathogen phagocytosis pathway; GPR40 pathway; Ras signaling; Non-small cell lung cancer; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; EGFR tyrosine kinase inhibitor resistance; GDNF signaling; 2q13 copy number variation syndrome; ErbB signaling pathway" "Role of phospholipids in phagocytosis; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Generation of second messenger molecules; CLEC7A (Dectin-1) signaling; Toll Like Receptor 4 (TLR4) Cascade; GPVI-mediated activation cascade; DAP12 signaling; Synthesis of IP3 and IP4 in the cytosol; Signaling by CSF1 (M-CSF) in myeloid cells; Erythropoietin activates Phospholipase C gamma (PLCG); Dectin-2 family" "30" "0" "1.044" "1.040" "1.087" "1.082" "1.041" "0.981" "0.611" "0.976" "6.136" "312.6" "326.4" "325.1" "339.9" "338.3" "325.3" "306.5" "191.1" "304.9" "1917.9" "" "" "" "" "" "" "" "" "" "" "165.5" "180.9" "186.2" "156.5" "183.0" "180.9" "180.4" "104.3" "171.1" "1917.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8029242028913948624" "False" "High" "IsMasterProtein" "Q92614" "Unconventional myosin-XVIIIa OS=Homo sapiens OX=9606 GN=MYO18A PE=1 SV=3" "0.000" "False" "19.384" "3" "7" "7" "7" "2054" "233.0" "6.30" "17.61" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00063, Pf00595, Pf01576" "399687" "ENSG00000196535" "MYO18A" "hsa:399687; Q5H9U3; Q5QD01; Q5W9F9; Q5W9G1; Q8IXP8; Q92614" "" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; Signaling by FLT3 fusion proteins" "3" "0" "1.021" "1.054" "1.220" "1.109" "1.044" "1.252" "0.922" "1.183" "4.100" "324.4" "331.2" "341.9" "395.8" "359.8" "338.6" "406.0" "299.0" "383.7" "1330.0" "" "" "" "" "" "" "" "" "" "" "171.8" "183.6" "195.8" "182.3" "194.7" "188.3" "238.9" "163.2" "215.2" "1330.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1314773965349869651" "False" "High" "IsMasterProtein" "Q9BRP8" "Partner of Y14 and mago OS=Homo sapiens OX=9606 GN=PYM1 PE=1 SV=1" "0.000" "False" "19.346" "28" "4" "5" "4" "204" "22.6" "9.45" "15.46" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity" "Pf09282" "84305" "ENSG00000170473" "PYM1" "B6ZDM5; hsa:84305; Q8IXJ8; Q8N8E7; Q9BRP8" "TAR syndrome" "" "1" "0" "1.012" "1.139" "0.914" "0.954" "0.980" "0.802" "0.713" "0.711" "0.494" "318.3" "322.1" "362.6" "291.0" "303.7" "312.0" "255.2" "226.8" "226.3" "157.2" "" "" "" "" "" "" "" "" "" "" "168.5" "178.6" "207.7" "134.0" "164.3" "173.5" "150.2" "123.8" "126.9" "157.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3196663768808374141" "False" "High" "IsMasterProtein" "Q9UBP6" "tRNA (guanine-N(7)-)-methyltransferase OS=Homo sapiens OX=9606 GN=METTL1 PE=1 SV=1" "0.000" "False" "19.289" "12" "3" "9" "3" "276" "31.5" "7.64" "28.17" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02390" "4234" "ENSG00000037897" "METTL1" "B2RBX1; H7BXF2; hsa:4234; Q14105; Q53FS9; Q9UBP6" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.868" "0.907" "0.922" "0.852" "0.922" "0.865" "0.746" "1.158" "0.672" "91.7" "79.6" "83.2" "84.6" "78.2" "84.5" "79.3" "68.4" "106.2" "61.6" "" "" "" "" "" "" "" "" "" "" "48.6" "44.1" "47.6" "38.9" "42.3" "47.0" "46.7" "37.4" "59.6" "61.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7415542887713691593" "False" "High" "IsMasterProtein" "Q01469" "Fatty acid-binding protein 5 OS=Homo sapiens OX=9606 GN=FABP5 PE=1 SV=3" "0.000" "False" "19.286" "27" "5" "10" "5" "135" "15.2" "7.01" "22.75" "5" "other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00061" "2171" "ENSG00000164687" "FABP5" "B2R4K0; hsa:2171; Q01469" "PPAR signaling pathway; Fatty acid transporters" "Neutrophil degranulation; Triglyceride catabolism; Signaling by Retinoic Acid" "5" "0" "0.965" "1.114" "0.954" "0.921" "0.971" "0.906" "1.052" "0.917" "0.485" "1196.3" "1154.5" "1333.0" "1140.7" "1102.1" "1161.9" "1084.2" "1258.9" "1096.8" "579.9" "" "" "" "" "" "" "" "" "" "" "633.4" "640.1" "763.4" "525.4" "596.3" "646.3" "638.1" "687.2" "615.3" "579.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4473457085686512926" "False" "High" "IsMasterProtein" "Q16186" "Proteasomal ubiquitin receptor ADRM1 OS=Homo sapiens OX=9606 GN=ADRM1 PE=1 SV=2" "0.000" "False" "19.279" "13" "6" "11" "6" "407" "42.1" "5.07" "32.81" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04683, Pf16550" "11047" "ENSG00000130706" "ADRM1" "A0PKB1; hsa:11047; Q16186; Q96FJ7; Q9H1P2" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "Ub-specific processing proteases; UCH proteinases" "4" "0" "1.052" "0.946" "1.079" "1.016" "1.023" "0.921" "0.989" "0.914" "1.012" "1194.0" "1255.7" "1128.9" "1288.0" "1213.1" "1221.4" "1100.2" "1180.9" "1090.8" "1207.8" "" "" "" "" "" "" "" "" "" "" "632.2" "696.2" "646.5" "593.2" "656.3" "679.4" "647.5" "644.6" "611.9" "1207.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2260293505055803748" "False" "High" "IsMasterProtein" "Q5JSZ5" "Protein PRRC2B OS=Homo sapiens OX=9606 GN=PRRC2B PE=1 SV=2" "0.000" "False" "19.273" "3" "8" "8" "8" "2229" "242.8" "8.34" "15.76" "8" "other biological processes" "" "" "Pf07001" "84726" "ENSG00000288701" "PRRC2B" "hsa:84726; O60270; Q5JSZ5; Q5JSZ7; Q66VZ2; Q68CR0; Q96EI9; Q9H683" "" "" "0" "0" "0.967" "0.960" "1.157" "1.140" "1.028" "1.288" "1.335" "1.270" "0.618" "410.8" "397.4" "394.4" "475.1" "468.4" "422.4" "529.0" "548.6" "521.6" "254.0" "" "" "" "" "" "" "" "" "" "" "217.5" "220.3" "225.9" "218.8" "253.4" "234.9" "311.3" "299.5" "292.6" "254.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6978047849896927875" "False" "High" "IsMasterProtein" "O15234" "Protein CASC3 OS=Homo sapiens OX=9606 GN=CASC3 PE=1 SV=2" "0.000" "False" "19.262" "4" "3" "5" "3" "703" "76.2" "6.48" "15.53" "3" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09405" "22794" "ENSG00000108349" "CASC3" "A8K8R0; O15234" "" "Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "6" "0" "0.896" "1.114" "1.034" "1.020" "0.815" "0.818" "0.901" "0.898" "0.766" "231.4" "207.4" "257.8" "239.2" "235.9" "188.5" "189.2" "208.4" "207.9" "177.2" "" "" "" "" "" "" "" "" "" "" "122.5" "115.0" "147.6" "110.2" "127.7" "104.9" "111.4" "113.8" "116.6" "177.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8881976693439910842" "False" "High" "IsMasterProtein" "P40306" "Proteasome subunit beta type-10 OS=Homo sapiens OX=9606 GN=PSMB10 PE=1 SV=1" "0.000" "False" "19.226" "14" "4" "8" "4" "273" "28.9" "7.81" "20.87" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf12465" "5699" "ENSG00000205220" "PSMB10" "B2R5J4; hsa:5699; P40306; Q5U098" "Proteasome degradation" "Degradation of beta-catenin by the destruction complex; Separation of Sister Chromatids; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "60" "0" "0.971" "0.993" "0.902" "0.902" "0.973" "1.069" "0.962" "0.905" "0.501" "888.2" "862.7" "881.7" "801.3" "800.7" "864.1" "949.8" "854.5" "804.2" "445.1" "" "" "" "" "" "" "" "" "" "" "470.3" "478.3" "505.0" "369.0" "433.2" "480.7" "559.0" "466.4" "451.2" "445.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5032092853006601019" "False" "High" "IsMasterProtein" "Q13303" "Voltage-gated potassium channel subunit beta-2 OS=Homo sapiens OX=9606 GN=KCNAB2 PE=1 SV=2" "0.000" "False" "19.221" "14" "7" "9" "7" "367" "41.0" "9.00" "23.61" "7" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "transporter activity;other molecular function" "Pf00248" "8514" "ENSG00000069424" "KCNAB2" "A0AVM9; A8K1A4; B0AZR7; hsa:8514; O43659; Q13303; Q2YD85; Q5TG82; Q5TG83; Q6ZNE4; Q99411" "Metapathway biotransformation Phase I and II" "Neutrophil degranulation; Voltage gated Potassium channels" "3" "0" "0.990" "1.015" "1.006" "1.035" "1.021" "1.060" "1.041" "0.959" "0.655" "786.9" "779.0" "798.6" "791.3" "814.5" "803.0" "834.0" "819.4" "754.2" "515.3" "" "" "" "" "" "" "" "" "" "" "416.6" "431.9" "457.3" "364.4" "440.6" "446.7" "490.9" "447.3" "423.1" "515.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-597243898993742241" "False" "High" "IsMasterProtein" "P17096" "High mobility group protein HMG-I/HMG-Y OS=Homo sapiens OX=9606 GN=HMGA1 PE=1 SV=3" "0.000" "False" "19.216" "37" "5" "11" "5" "107" "11.7" "10.32" "29.62" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "" "3159" "ENSG00000137309" "HMGA1" "hsa:3159; P10910; P17096; Q5T6U9; Q9UKB0" "Adipogenesis; Pre-implantation embryo; Male infertility; 7q11.23 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Orexin receptor pathway" "Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "13" "0" "1.017" "1.037" "1.199" "1.055" "1.006" "1.091" "1.011" "0.973" "0.493" "560.5" "570.0" "581.0" "671.9" "591.4" "563.6" "611.8" "566.9" "545.3" "276.3" "" "" "" "" "" "" "" "" "" "" "296.8" "316.0" "332.7" "309.4" "320.0" "313.5" "360.0" "309.5" "305.9" "276.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7463755477932393031" "False" "High" "IsMasterProtein" "Q9H4M9" "EH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=EHD1 PE=1 SV=2" "0.000" "False" "19.213" "12" "6" "7" "6" "534" "60.6" "6.83" "15.89" "6" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00350, Pf12763, Pf16880, Pf18150" "10938" "ENSG00000110047" "EHD1" "hsa:10938; O14611; Q2M3Q4; Q9H4M9; Q9UNR3" "Insulin signaling" "Factors involved in megakaryocyte development and platelet production" "2" "0" "1.008" "0.962" "1.042" "1.125" "1.114" "0.952" "0.823" "0.852" "0.806" "377.5" "380.4" "363.4" "393.3" "424.8" "420.5" "359.4" "310.7" "321.5" "304.4" "" "" "" "" "" "" "" "" "" "" "199.9" "210.9" "208.1" "181.1" "229.8" "233.9" "211.5" "169.6" "180.4" "304.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-105519067553436175" "False" "High" "IsMasterProtein" "Q04323" "UBX domain-containing protein 1 OS=Homo sapiens OX=9606 GN=UBXN1 PE=1 SV=2" "0.000" "False" "19.209" "16" "2" "2" "2" "297" "33.3" "5.25" "8.24" "2" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00627, Pf00789" "51035" "ENSG00000162191" "UBXN1" "hsa:51035; Q04323; Q9BV93; Q9BVV5" "" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "2" "0" "1.215" "0.952" "1.404" "1.245" "1.200" "1.134" "1.181" "1.070" "1.275" "36.1" "43.9" "34.4" "50.7" "45.0" "43.3" "41.0" "42.7" "38.7" "46.0" "" "" "" "" "" "" "" "" "" "" "19.1" "24.3" "19.7" "23.3" "24.3" "24.1" "24.1" "23.3" "21.7" "46.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1997849162023251854" "False" "High" "IsMasterProtein" "P63208" "S-phase kinase-associated protein 1 OS=Homo sapiens OX=9606 GN=SKP1 PE=1 SV=2" "0.000" "False" "19.191" "28" "4" "4" "4" "163" "18.6" "4.54" "12.43" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01466, Pf03931" "6500" "ENSG00000113558" "SKP1" "D3DQ97; D3DQ98; hsa:6500; P34991; P63208; Q8TAY2" "Cell cycle; TNF-alpha signaling pathway; TGF-beta signaling pathway; Breast cancer pathway; Small cell lung cancer; Notch signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Regulation of RUNX2 expression and activity; Circadian Clock; Antigen processing: Ubiquitination & Proteasome degradation; SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Neddylation; Regulation of PLK1 Activity at G2/M Transition; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Cyclin D associated events in G1; Regulation of BACH1 activity; MAP3K8 (TPL2)-dependent MAPK1/3 activation; NOTCH1 Intracellular Domain Regulates Transcription; Prolactin receptor signaling; Iron uptake and transport; Nuclear events stimulated by ALK signaling in cancer; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling" "39" "0" "1.133" "1.218" "1.181" "1.048" "0.859" "1.053" "1.277" "1.073" "0.519" "173.6" "196.7" "211.5" "205.0" "182.0" "149.1" "182.7" "221.6" "186.3" "90.0" "" "" "" "" "" "" "" "" "" "" "91.9" "109.0" "121.1" "94.4" "98.5" "82.9" "107.6" "121.0" "104.5" "90.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4002844298631346291" "False" "High" "IsMasterProtein" "Q53H47" "Histone-lysine N-methyltransferase SETMAR OS=Homo sapiens OX=9606 GN=SETMAR PE=1 SV=2" "0.000" "False" "19.183" "9" "6" "7" "6" "684" "78.0" "7.14" "15.64" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00856, Pf01359, Pf05033, Pf17906" "6419" "ENSG00000170364" "SETMAR" "B4DY74; E7EN68; hsa:6419; Q13579; Q1G668; Q53H47; Q96F41" "Histone modifications" "" "1" "0" "1.077" "0.954" "1.069" "1.172" "1.045" "1.120" "0.996" "1.236" "0.946" "460.2" "495.4" "439.2" "491.8" "539.2" "480.8" "515.3" "458.3" "568.6" "435.2" "" "" "" "" "" "" "" "" "" "" "243.7" "274.7" "251.5" "226.5" "291.7" "267.4" "303.2" "250.2" "319.0" "435.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3557205944014884156" "False" "High" "IsMasterProtein" "P20339" "Ras-related protein Rab-5A OS=Homo sapiens OX=9606 GN=RAB5A PE=1 SV=2" "0.000" "False" "19.172" "21" "4" "5" "2" "215" "23.6" "8.15" "13.79" "4" "cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5868" "ENSG00000144566" "RAB5A" "B4DJA5; hsa:5868; P20339; Q6FI44" "Amyotrophic lateral sclerosis (ALS); VEGFA-VEGFR2 signaling; Ebola virus infection in host; Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway; 16p11.2 distal deletion syndrome; Vasopressin-regulated water reabsorption" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Respiratory syncytial virus (RSV) attachment and entry; Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; Factors involved in megakaryocyte development and platelet production; Prevention of phagosomal-lysosomal fusion; TBC/RABGAPs" "16" "0" "1.131" "0.987" "1.214" "1.097" "1.156" "1.183" "1.166" "1.014" "0.624" "131.8" "149.2" "130.1" "160.1" "144.6" "152.4" "156.0" "153.8" "133.7" "82.3" "" "" "" "" "" "" "" "" "" "" "69.8" "82.7" "74.5" "73.7" "78.2" "84.7" "91.8" "83.9" "75.0" "82.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8307908846177998742" "False" "High" "IsMasterProtein" "P20248" "Cyclin-A2 OS=Homo sapiens OX=9606 GN=CCNA2 PE=1 SV=2" "0.000" "False" "19.160" "13" "6" "11" "6" "432" "48.5" "6.54" "28.04" "6" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00134, Pf02984, Pf16500" "890" "ENSG00000145386" "CCNA2" "A8K7B6; hsa:890; P20248; Q2M3U6; Q4W5P4; Q6LER8" "AMP-activated protein kinase signaling; Cell cycle; Retinoblastoma gene in cancer; Photodynamic therapy-induced AP-1 survival signaling; IL-18 signaling pathway; Acute myeloid leukemia; NF1 copy number variation syndrome" "Senescence-Associated Secretory Phenotype (SASP); TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; Regulation of TP53 Degradation; SCF(Skp2)-mediated degradation of p27/p21; Regulation of TP53 Activity through Phosphorylation; G2 Phase; Telomere Extension By Telomerase; Regulation of APC/C activators between G1/S and early anaphase; Processing of DNA double-strand break ends; DNA Damage/Telomere Stress Induced Senescence; p53-Dependent G1 DNA Damage Response; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes" "27" "0" "1.006" "0.959" "1.062" "1.076" "1.092" "0.995" "1.021" "1.023" "0.676" "534.2" "537.5" "512.2" "567.2" "574.6" "583.4" "531.7" "545.7" "546.3" "360.9" "" "" "" "" "" "" "" "" "" "" "282.9" "298.0" "293.4" "261.2" "310.9" "324.5" "312.9" "297.9" "306.5" "360.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5625236690753071245" "False" "High" "IsMasterProtein" "P22061" "Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Homo sapiens OX=9606 GN=PCMT1 PE=1 SV=4" "0.000" "False" "19.154" "21" "5" "6" "5" "227" "24.6" "7.21" "18.36" "5" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01135" "5110" "ENSG00000120265" "PCMT1" "A8K109; hsa:5110; J3KP72; P22061; Q14661; Q16556; Q5VYC1; Q5VYC2; Q93061; Q96II9; Q99625; Q9BQV7; Q9BQV8; Q9NP03" "Primary ovarian insufficiency" "Protein repair" "2" "0" "1.029" "1.083" "0.945" "1.044" "1.073" "1.000" "1.031" "1.038" "0.641" "509.7" "524.4" "552.0" "481.6" "532.4" "547.1" "509.6" "525.5" "529.2" "326.5" "" "" "" "" "" "" "" "" "" "" "269.9" "290.7" "316.1" "221.8" "288.0" "304.3" "299.9" "286.9" "296.9" "326.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9134922039646345365" "False" "High" "IsMasterProtein" "Q8NBF2" "NHL repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=NHLRC2 PE=1 SV=1" "0.000" "False" "19.150" "7" "6" "8" "6" "726" "79.4" "5.55" "24.68" "6" "" "non-structural extracellular;cytosol;other cell component" "" "Pf01436, Pf13905" "374354" "ENSG00000196865" "NHLRC2" "hsa:374354; Q8N1H1; Q8N5A6; Q8NBF2" "" "Platelet degranulation" "1" "0" "1.096" "0.985" "0.993" "0.942" "1.029" "0.918" "0.814" "0.873" "1.117" "504.1" "552.4" "496.7" "500.4" "474.8" "518.9" "462.9" "410.2" "440.1" "563.2" "" "" "" "" "" "" "" "" "" "" "266.9" "306.3" "284.5" "230.4" "256.9" "288.6" "272.4" "223.9" "246.9" "563.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5959854138225624200" "False" "High" "IsMasterProtein" "Q7Z6E9" "E3 ubiquitin-protein ligase RBBP6 OS=Homo sapiens OX=9606 GN=RBBP6 PE=1 SV=1" "0.000" "False" "19.138" "4" "7" "7" "7" "1792" "201.4" "9.64" "19.13" "7" "protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf04564, Pf08783, Pf13696" "5930" "ENSG00000122257" "RBBP6" "Q147T5; Q15290; Q6DKH4; Q6P4C2; Q6YNC9; Q7Z6E8; Q7Z6E9; Q8N0V2; Q96PH3; Q9H3I8; Q9H5M5; Q9NPX4" "" "RHOBTB1 GTPase cycle; Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "0.998" "1.010" "1.204" "1.238" "1.169" "1.780" "1.867" "1.824" "0.823" "568.5" "567.1" "574.3" "684.2" "703.9" "664.5" "1011.6" "1061.4" "1036.6" "467.8" "" "" "" "" "" "" "" "" "" "" "301.0" "314.4" "328.9" "315.1" "380.8" "369.6" "595.4" "579.3" "581.5" "467.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4497117085705849008" "False" "High" "IsMasterProtein" "Q9UHY1" "Nuclear receptor-binding protein OS=Homo sapiens OX=9606 GN=NRBP1 PE=1 SV=1" "0.000" "False" "19.134" "9" "3" "4" "3" "535" "59.8" "5.08" "13.65" "3" "transport" "other membranes;nucleus;other cell component" "kinase activity;other molecular function" "Pf07714" "29959" "ENSG00000115216" "NRBP1" "B3KV40; D6W558; hsa:29959; Q53FZ5; Q96SU3; Q9UHY1" "" "Nuclear Receptor transcription pathway" "1" "0" "1.559" "1.108" "1.209" "2.041" "1.742" "1.376" "1.253" "1.255" "1.236" "31.7" "49.4" "35.1" "38.3" "64.7" "55.2" "43.6" "39.7" "39.8" "39.2" "" "" "" "" "" "" "" "" "" "" "16.8" "27.4" "20.1" "17.6" "35.0" "30.7" "25.7" "21.7" "22.3" "39.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3533447776593040930" "False" "High" "IsMasterProtein" "P26599" "Polypyrimidine tract-binding protein 1 OS=Homo sapiens OX=9606 GN=PTBP1 PE=1 SV=2" "0.000" "False" "19.133" "12" "8" "14" "5" "557" "59.6" "9.16" "32.32" "8" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "5725" "ENSG00000011304" "PTBP1" "hsa:5725; P26599; Q9BUQ0" "mir-124 predicted interactions with cell cycle and differentiation ; mRNA processing" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "5" "2" "0.956" "0.978" "1.070" "0.952" "0.980" "0.933" "0.574" "0.948" "5.336" "428.0" "409.2" "418.8" "458.1" "407.6" "419.4" "399.4" "245.9" "405.9" "2283.9" "" "" "" "" "" "" "" "" "" "" "226.6" "226.9" "239.8" "211.0" "220.5" "233.3" "235.1" "134.2" "227.7" "2283.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2580326738670543746" "False" "High" "IsMasterProtein" "O60341" "Lysine-specific histone demethylase 1A OS=Homo sapiens OX=9606 GN=KDM1A PE=1 SV=2" "0.000" "False" "19.114" "10" "7" "7" "7" "852" "92.8" "6.52" "17.81" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01593, Pf04433" "23028" "ENSG00000004487" "KDM1A" "A8MWP9; hsa:23028; O60341; Q5TH94; Q5TH95; Q86VT7; Q8IXK4; Q8NDP6; Q8TAZ3; Q96AW4" "Androgen receptor signaling pathway; Effect of progerin on genes involved in progeria; Thermogenesis; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects; Neurogenesis regulation in the olfactory epithelium" "Estrogen-dependent gene expression; Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3" "14" "0" "1.002" "0.941" "0.866" "1.047" "1.065" "0.982" "0.894" "1.091" "2.704" "244.8" "245.3" "230.3" "211.8" "256.2" "260.6" "240.5" "218.8" "267.0" "661.8" "" "" "" "" "" "" "" "" "" "" "129.6" "136.0" "131.9" "97.6" "138.6" "144.9" "141.5" "119.4" "149.8" "661.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3959098677357932626" "False" "High" "IsMasterProtein" "O43747" "AP-1 complex subunit gamma-1 OS=Homo sapiens OX=9606 GN=AP1G1 PE=1 SV=5" "0.000" "False" "19.112" "7" "7" "10" "6" "822" "91.3" "6.80" "26.96" "7" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf01602, Pf02883" "164" "ENSG00000166747" "AP1G1" "hsa:164; O43747; O75709; O75842; Q9UG09; Q9Y3U4" "" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "4" "0" "1.007" "0.944" "0.951" "1.041" "1.013" "1.342" "1.272" "1.508" "3.178" "483.7" "487.0" "456.8" "460.1" "503.4" "489.9" "649.2" "615.4" "729.3" "1537.2" "" "" "" "" "" "" "" "" "" "" "256.1" "270.0" "261.6" "211.9" "272.4" "272.5" "382.0" "335.9" "409.1" "1537.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9060406091306601688" "False" "High" "IsMasterProtein" "Q8N806" "Putative E3 ubiquitin-protein ligase UBR7 OS=Homo sapiens OX=9606 GN=UBR7 PE=1 SV=2" "0.000" "False" "19.105" "10" "4" "5" "4" "425" "48.0" "4.81" "15.69" "4" "protein metabolism;other metabolic processes" "" "other molecular function" "Pf02207" "55148" "ENSG00000012963; ENSG00000278787" "UBR7" "Q86U21; Q86UA9; Q8N806; Q96BY0; Q9NVV6" "" "" "0" "0" "0.967" "1.044" "1.038" "0.951" "1.051" "1.024" "1.029" "1.104" "1.202" "478.2" "462.5" "499.4" "496.6" "454.6" "502.5" "489.5" "491.9" "528.1" "575.0" "" "" "" "" "" "" "" "" "" "" "253.2" "256.4" "286.0" "228.7" "246.0" "279.5" "288.1" "268.5" "296.2" "575.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2601253202356678168" "False" "High" "IsMasterProtein" "P31937" "3-hydroxyisobutyrate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=HIBADH PE=1 SV=2" "0.000" "False" "19.094" "9" "2" "5" "2" "336" "35.3" "8.13" "16.62" "2" "other metabolic processes" "mitochondrion" "other molecular function" "Pf03446, Pf14833" "11112" "ENSG00000106049" "HIBADH" "hsa:11112; P31937; Q546Z2; Q9UDN3" "Amino acid metabolism" "Branched-chain amino acid catabolism" "2" "0" "1.004" "1.107" "0.994" "1.120" "1.103" "1.079" "1.106" "1.044" "0.553" "370.7" "372.2" "410.3" "368.4" "415.3" "408.9" "399.9" "410.1" "386.9" "205.1" "" "" "" "" "" "" "" "" "" "" "196.3" "206.4" "235.0" "169.6" "224.7" "227.5" "235.4" "223.9" "217.1" "205.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8117558468974038429" "False" "High" "IsMasterProtein" "Q96Q11" "CCA tRNA nucleotidyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=TRNT1 PE=1 SV=2" "0.000" "False" "19.066" "10" "5" "7" "5" "434" "50.1" "8.10" "22.73" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf01743, Pf12627" "51095" "ENSG00000072756" "TRNT1" "A8K2Z6; B7WP13; C9JKA2; hsa:51095; Q8ND57; Q96Q11; Q9BS97; Q9Y362" "" "tRNA processing in the nucleus; tRNA processing in the mitochondrion" "2" "0" "0.987" "0.939" "1.050" "1.079" "1.137" "1.055" "0.909" "1.030" "1.417" "760.2" "750.6" "713.9" "798.2" "820.3" "864.4" "802.3" "691.0" "783.2" "1077.4" "" "" "" "" "" "" "" "" "" "" "402.5" "416.2" "408.8" "367.6" "443.8" "480.8" "472.2" "377.2" "439.4" "1077.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4636367879172640363" "False" "High" "IsMasterProtein" "P24666" "Low molecular weight phosphotyrosine protein phosphatase OS=Homo sapiens OX=9606 GN=ACP1 PE=1 SV=3" "0.000" "False" "19.064" "25" "3" "4" "3" "158" "18.0" "6.74" "14.42" "3" "" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01451" "52" "ENSG00000143727" "ACP1" "A8K1L9; B5MCC7; hsa:52; P24666; P24667; Q16035; Q16036; Q16725; Q3KQX8; Q53RU0" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.090" "0.911" "1.222" "1.036" "1.011" "1.045" "0.840" "0.894" "3.001" "253.4" "276.3" "230.9" "309.6" "262.5" "256.1" "264.6" "212.8" "226.6" "760.2" "" "" "" "" "" "" "" "" "" "" "134.2" "153.2" "132.2" "142.6" "142.0" "142.4" "155.8" "116.1" "127.1" "760.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3312961601966625911" "False" "High" "IsMasterProtein" "Q96EY8" "Corrinoid adenosyltransferase MMAB OS=Homo sapiens OX=9606 GN=MMAB PE=1 SV=1" "0.000" "False" "19.056" "18" "4" "7" "4" "250" "27.4" "8.60" "22.34" "4" "other metabolic processes" "mitochondrion" "other molecular function" "Pf01923" "326625" "ENSG00000139428" "MMAB" "C5HU05; hsa:326625; Q96EY8; Q9BSH0" "Vitamin B12 metabolism" "Cobalamin (Cbl) metabolism; Defective MMAB causes MMA, cblB type" "3" "0" "1.084" "1.099" "1.031" "1.058" "1.180" "1.059" "1.157" "1.167" "0.867" "583.5" "632.2" "641.1" "601.8" "617.5" "688.6" "618.1" "675.4" "681.1" "505.9" "" "" "" "" "" "" "" "" "" "" "308.9" "350.5" "367.2" "277.2" "334.1" "383.0" "363.8" "368.6" "382.1" "505.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5697914900789617779" "False" "High" "IsMasterProtein" "Q7RTV0" "PHD finger-like domain-containing protein 5A OS=Homo sapiens OX=9606 GN=PHF5A PE=1 SV=1" "0.000" "False" "19.027" "34" "4" "8" "4" "110" "12.4" "8.41" "20.09" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03660" "84844" "ENSG00000100410" "PHF5A" "hsa:84844; Q7RTV0; Q9UH06" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.989" "1.163" "0.973" "1.064" "0.996" "0.967" "1.166" "1.064" "0.449" "693.8" "686.4" "806.8" "675.2" "738.3" "691.0" "671.1" "808.8" "738.5" "311.2" "" "" "" "" "" "" "" "" "" "" "367.3" "380.5" "462.1" "311.0" "399.5" "384.4" "395.0" "441.5" "414.3" "311.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "654081652263858131" "False" "High" "IsMasterProtein" "Q12905" "Interleukin enhancer-binding factor 2 OS=Homo sapiens OX=9606 GN=ILF2 PE=1 SV=2" "0.000" "False" "19.010" "18" "5" "11" "5" "390" "43.0" "5.26" "18.33" "5" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf07528, Pf20965" "3608" "ENSG00000143621" "ILF2" "A6NDB0; B2R8G7; hsa:3608; Q12905; Q5SR10; Q5SR11; Q7L7R3; Q9BWD4; Q9P1N0" "B cell receptor signaling pathway" "Neutrophil degranulation; PKR-mediated signaling" "3" "0" "1.082" "0.986" "1.227" "1.203" "1.143" "1.073" "1.010" "1.113" "0.705" "188.2" "203.7" "185.6" "230.9" "226.4" "215.1" "202.0" "190.1" "209.4" "132.7" "" "" "" "" "" "" "" "" "" "" "99.6" "112.9" "106.3" "106.4" "122.5" "119.7" "118.9" "103.7" "117.5" "132.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6449077897622524501" "False" "High" "IsMasterProtein" "O95551" "Tyrosyl-DNA phosphodiesterase 2 OS=Homo sapiens OX=9606 GN=TDP2 PE=1 SV=1" "0.000" "False" "18.980" "13" "4" "6" "4" "362" "40.9" "5.10" "16.99" "4" "DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03372, Pf14555" "51567" "ENSG00000111802" "TDP2" "B4DKL8; B4DQ95; O95551; Q2TBE2; Q5JYM0; Q7Z6U5; Q9NUK5; Q9NYY9" "Oxidative damage response" "Nonhomologous End-Joining (NHEJ)" "2" "0" "1.202" "1.050" "1.169" "1.323" "1.247" "1.480" "1.251" "1.253" "1.636" "132.0" "158.6" "138.6" "154.3" "174.6" "164.6" "195.4" "165.1" "165.4" "215.9" "" "" "" "" "" "" "" "" "" "" "69.9" "87.9" "79.4" "71.0" "94.5" "91.5" "115.0" "90.1" "92.8" "215.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6442873191784740439" "False" "High" "IsMasterProtein" "Q9BXW7" "Haloacid dehalogenase-like hydrolase domain-containing 5 OS=Homo sapiens OX=9606 GN=HDHD5 PE=1 SV=1" "0.000" "False" "18.957" "16" "5" "5" "5" "423" "46.3" "8.13" "12.57" "5" "other metabolic processes" "mitochondrion" "" "Pf13344" "27440" "ENSG00000069998" "HDHD5" "B2RCK5; Q9BXW7; Q9BXW8; Q9NWA8; Q9NX41" "" "" "0" "0" "1.214" "1.105" "1.484" "1.162" "1.232" "1.204" "0.854" "1.037" "2.292" "128.8" "156.4" "142.4" "191.2" "149.8" "158.7" "155.1" "110.0" "133.6" "295.4" "" "" "" "" "" "" "" "" "" "" "68.2" "86.7" "81.5" "88.0" "81.0" "88.3" "91.3" "60.0" "74.9" "295.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1018884242771776576" "False" "High" "IsMasterProtein" "P30048" "Thioredoxin-dependent peroxide reductase, mitochondrial OS=Homo sapiens OX=9606 GN=PRDX3 PE=1 SV=3" "0.000" "False" "18.944" "14" "4" "20" "4" "256" "27.7" "7.78" "50.46" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00578, Pf10417" "10935" "ENSG00000165672" "PRDX3" "B2R7Z0; D3DRC9; E9PH29; hsa:10935; P30048; P35690; Q0D2H1; Q13776; Q5T5V2; Q96HK4" "Selenium micronutrient network" "Detoxification of Reactive Oxygen Species" "2" "0" "0.960" "0.994" "0.877" "1.006" "0.994" "0.961" "0.983" "0.896" "0.422" "867.3" "832.9" "861.8" "760.6" "872.2" "862.4" "833.4" "852.4" "777.0" "366.2" "" "" "" "" "" "" "" "" "" "" "459.3" "461.8" "493.5" "350.3" "471.9" "479.7" "490.5" "465.3" "435.9" "366.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3028893805167112372" "False" "High" "IsMasterProtein" "O75351" "Vacuolar protein sorting-associated protein 4B OS=Homo sapiens OX=9606 GN=VPS4B PE=1 SV=2" "0.000" "False" "18.936" "13" "6" "8" "6" "444" "49.3" "7.23" "16.86" "6" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00004, Pf04212, Pf09336, Pf17862" "9525" "ENSG00000119541" "VPS4B" "hsa:9525; O75351; Q69HW4; Q9GZS7" "" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)" "2" "0" "1.216" "1.094" "1.240" "1.246" "1.221" "1.269" "1.016" "1.071" "1.128" "301.2" "366.3" "329.7" "373.5" "375.3" "367.9" "382.2" "306.0" "322.5" "339.7" "" "" "" "" "" "" "" "" "" "" "159.5" "203.1" "188.8" "172.0" "203.0" "204.6" "224.9" "167.0" "180.9" "339.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6049594169438393906" "False" "High" "IsMasterProtein" "Q52LJ0" "Protein FAM98B OS=Homo sapiens OX=9606 GN=FAM98B PE=1 SV=2" "0.000" "False" "18.929" "12" "4" "6" "4" "433" "45.5" "8.69" "14.37" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10239" "283742" "ENSG00000171262" "FAM98B" "A8MUW5; hsa:283742; Q52LJ0; Q8N935" "" "tRNA processing in the nucleus" "1" "0" "0.805" "1.013" "0.838" "0.885" "1.015" "1.051" "1.086" "0.838" "0.680" "42.5" "34.2" "43.0" "35.6" "37.6" "43.1" "44.6" "46.1" "35.6" "28.9" "" "" "" "" "" "" "" "" "" "" "22.5" "19.0" "24.6" "16.4" "20.3" "24.0" "26.3" "25.2" "20.0" "28.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8926098929249154387" "False" "High" "IsMasterProtein" "Q9NR28" "Diablo IAP-binding mitochondrial protein OS=Homo sapiens OX=9606 GN=DIABLO PE=1 SV=1" "0.000" "False" "18.920" "24" "6" "12" "6" "239" "27.1" "5.90" "27.72" "6" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion" "" "Pf09057" "56616" "ENSG00000184047" "DIABLO" "B2RDQ0; hsa:56616; Q6W3F3; Q96LV0; Q9BT11; Q9HAV6; Q9NR28" "Apoptosis modulation and signaling; TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Apoptosis; Complement system in neuronal development and plasticity" "Regulation of the apoptosome activity; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Release of apoptotic factors from the mitochondria" "10" "0" "1.097" "1.080" "0.957" "1.000" "0.944" "0.879" "1.030" "1.045" "0.512" "877.3" "962.3" "947.3" "839.4" "877.7" "827.9" "771.0" "903.7" "916.7" "449.1" "" "" "" "" "" "" "" "" "" "" "464.5" "533.5" "542.5" "386.6" "474.9" "460.5" "453.7" "493.3" "514.2" "449.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5439043522832827691" "False" "High" "IsMasterProtein" "Q8WZA0" "Protein LZIC OS=Homo sapiens OX=9606 GN=LZIC PE=1 SV=1" "0.000" "False" "18.909" "25" "5" "6" "5" "190" "21.5" "4.94" "16.62" "5" "other biological processes" "" "other molecular function" "Pf06384" "84328" "ENSG00000162441" "LZIC" "B2R6F0; B4E2N0; hsa:84328; Q8WZA0; Q96IU1" "" "" "0" "0" "1.137" "1.093" "0.923" "0.996" "0.999" "0.954" "1.305" "1.232" "0.527" "350.2" "398.2" "382.7" "323.1" "348.9" "349.7" "334.0" "456.8" "431.3" "184.6" "" "" "" "" "" "" "" "" "" "" "185.4" "220.8" "219.2" "148.8" "188.8" "194.5" "196.5" "249.4" "241.9" "184.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6945972540220555835" "False" "High" "IsMasterProtein" "Q96ST3" "Paired amphipathic helix protein Sin3a OS=Homo sapiens OX=9606 GN=SIN3A PE=1 SV=2" "0.000" "False" "18.905" "5" "5" "5" "5" "1273" "145.1" "7.25" "12.46" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02671, Pf08295, Pf16879" "25942" "ENSG00000169375" "SIN3A" "B2RNS5; Q8N8N4; Q8NC83; Q8WV18; Q96L98; Q96ST3; Q9UFQ1" "Androgen receptor signaling pathway; Retinoblastoma gene in cancer; MECP2 and associated Rett syndrome; TGF-beta signaling pathway; Transcription co-factors SKI and SKIL protein partners; Hedgehog signaling pathway; 15q11q13 copy number variation" "Cytoprotection by HMOX1; Factors involved in megakaryocyte development and platelet production; NoRC negatively regulates rRNA expression; STAT3 nuclear events downstream of ALK signaling; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; SUMOylation of transcription cofactors; MECP2 regulates transcription of neuronal ligands; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Regulation of lipid metabolism by PPARalpha; Regulation of MECP2 expression and activity; MECP2 regulates neuronal receptors and channels; Loss of MECP2 binding ability to 5mC-DNA" "19" "0" "1.008" "1.053" "1.136" "1.174" "1.168" "1.462" "1.264" "1.314" "2.378" "250.8" "252.7" "264.1" "285.0" "294.5" "293.0" "366.7" "317.1" "329.5" "596.6" "" "" "" "" "" "" "" "" "" "" "132.8" "140.1" "151.2" "131.2" "159.3" "163.0" "215.8" "173.1" "184.8" "596.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6706450895826488783" "False" "High" "IsMasterProtein" "Q9H9Q2" "COP9 signalosome complex subunit 7b OS=Homo sapiens OX=9606 GN=COPS7B PE=1 SV=1" "0.000" "False" "18.888" "16" "3" "4" "3" "264" "29.6" "6.15" "14.66" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01399, Pf18392" "64708" "ENSG00000144524" "COPS7B" "hsa:64708; Q53S22; Q5BJG3; Q9H7V6; Q9H9Q2" "Ciliary landscape" "Neddylation; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER; Cargo recognition for clathrin-mediated endocytosis" "5" "0" "1.025" "1.058" "1.026" "1.109" "1.053" "1.033" "1.033" "1.062" "0.748" "362.6" "371.7" "383.5" "372.0" "402.0" "381.8" "374.6" "374.6" "385.0" "271.1" "" "" "" "" "" "" "" "" "" "" "192.0" "206.1" "219.6" "171.3" "217.5" "212.4" "220.5" "204.5" "216.0" "271.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7018160903413407228" "False" "High" "IsMasterProtein" "Q9BW85" "Splicing factor YJU2 OS=Homo sapiens OX=9606 GN=YJU2 PE=1 SV=1" "0.000" "False" "18.876" "15" "4" "5" "3" "323" "37.1" "5.92" "17.85" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf04502" "55702" "ENSG00000105248" "YJU2" "hsa:55702; O75270; Q9BW85; Q9H862; Q9NW16" "" "mRNA Splicing - Major Pathway" "1" "1" "0.986" "1.136" "1.039" "0.954" "1.039" "0.991" "1.175" "1.091" "1.306" "594.0" "585.8" "674.8" "617.4" "566.9" "617.4" "588.5" "698.1" "647.9" "775.7" "" "" "" "" "" "" "" "" "" "" "314.5" "324.8" "386.5" "284.3" "306.7" "343.4" "346.3" "381.1" "363.4" "775.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3583580330514197896" "False" "High" "IsMasterProtein" "P55809" "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=OXCT1 PE=1 SV=1" "0.000" "False" "18.870" "12" "6" "8" "6" "520" "56.1" "7.46" "21.86" "6" "other metabolic processes" "mitochondrion" "other molecular function" "Pf01144" "5019" "ENSG00000083720" "OXCT1" "B2R5V2; B7Z528; hsa:5019; P55809" "" "Mitochondrial protein degradation; Utilization of Ketone Bodies" "2" "0" "0.912" "0.868" "0.901" "0.916" "0.911" "0.881" "0.852" "0.852" "0.887" "261.2" "238.3" "226.6" "235.4" "239.3" "237.9" "230.1" "222.7" "222.7" "231.8" "" "" "" "" "" "" "" "" "" "" "138.3" "132.1" "129.8" "108.4" "129.5" "132.3" "135.4" "121.5" "124.9" "231.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5102173735616793815" "False" "High" "IsMasterProtein" "Q9BWH6" "RNA polymerase II-associated protein 1 OS=Homo sapiens OX=9606 GN=RPAP1 PE=1 SV=3" "0.000" "False" "18.863" "3" "3" "4" "3" "1393" "152.7" "6.38" "11.66" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08620, Pf08621" "26015" "ENSG00000103932" "RPAP1" "hsa:26015; Q9BWH6; Q9H9I2; Q9NSQ5; Q9P2E4; Q9UFS7" "" "" "0" "0" "1.178" "1.251" "1.257" "1.181" "1.167" "1.170" "0.919" "1.092" "1.479" "96.5" "113.7" "120.7" "121.4" "114.0" "112.6" "112.9" "88.7" "105.4" "142.7" "" "" "" "" "" "" "" "" "" "" "51.1" "63.0" "69.1" "55.9" "61.7" "62.6" "66.5" "48.4" "59.2" "142.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "208143562843118343" "False" "High" "IsMasterProtein" "Q8NFH5" "Nucleoporin NUP35 OS=Homo sapiens OX=9606 GN=NUP35 PE=1 SV=1" "0.000" "False" "18.796" "16" "4" "4" "4" "326" "34.8" "9.09" "11.21" "4" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05172" "129401" "ENSG00000163002" "NUP35" "B4DP57; B4DYB4; hsa:129401; Q4ZFZ9; Q53S95; Q8NFH5; Q8TDJ1" "" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; HCMV Early Events; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation" "29" "0" "1.064" "0.983" "1.235" "1.228" "1.095" "1.112" "1.204" "1.200" "0.734" "346.0" "368.1" "340.1" "427.3" "425.0" "378.7" "384.7" "416.4" "415.1" "253.8" "" "" "" "" "" "" "" "" "" "" "183.2" "204.1" "194.8" "196.8" "229.9" "210.7" "226.4" "227.3" "232.9" "253.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2621085061721332365" "False" "High" "IsMasterProtein" "P48382" "DNA-binding protein RFX5 OS=Homo sapiens OX=9606 GN=RFX5 PE=1 SV=1" "0.000" "False" "18.760" "13" "7" "8" "7" "616" "65.3" "9.29" "17.40" "7" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02257, Pf14621, Pf18326" "5993" "ENSG00000143390" "RFX5" "B7Z848; D3DV19; E9PFU4; hsa:5993; P48382; Q5VWC3" "Prion disease pathway; IL-18 signaling pathway" "" "2" "0" "0.984" "0.991" "1.110" "1.011" "1.024" "0.963" "0.977" "1.017" "1.057" "501.3" "493.5" "496.7" "556.4" "506.6" "513.3" "483.0" "489.9" "509.6" "530.0" "" "" "" "" "" "" "" "" "" "" "265.4" "273.6" "284.4" "256.2" "274.1" "285.5" "284.2" "267.4" "285.9" "530.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4173136633731686100" "False" "High" "IsMasterProtein" "P29590" "Protein PML OS=Homo sapiens OX=9606 GN=PML PE=1 SV=3" "0.000" "False" "18.749" "7" "6" "7" "6" "882" "97.5" "6.21" "18.20" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097, Pf00643, Pf12126" "5371" "ENSG00000140464" "PML" "E9PBR7; hsa:5371; P29590; P29591; P29592; P29593; Q00755; Q15959; Q59FP9; Q8WUA0; Q96S41; Q9BPW2; Q9BWP7; Q9BZX6; Q9BZX7; Q9BZX8; Q9BZX9; Q9BZY0; Q9BZY2; Q9BZY3" "miRNA regulation of DNA damage response; Wnt/beta-catenin signaling pathway in leukemia; TGF-beta signaling pathway; p53 transcriptional gene network; Acute myeloid leukemia; DNA damage response" "Interferon gamma signaling; HCMV Early Events; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Regulation of TP53 Activity through Acetylation; Regulation of PTEN localization; Regulation of RUNX1 Expression and Activity" "13" "0" "0.976" "0.995" "1.058" "1.143" "1.039" "1.128" "1.152" "1.181" "1.681" "573.7" "559.8" "571.1" "606.7" "655.6" "596.1" "647.2" "660.9" "677.6" "964.1" "" "" "" "" "" "" "" "" "" "" "303.7" "310.4" "327.1" "279.4" "354.7" "331.6" "380.9" "360.8" "380.1" "964.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6490484038664760531" "False" "High" "IsMasterProtein" "Q13283" "Ras GTPase-activating protein-binding protein 1 OS=Homo sapiens OX=9606 GN=G3BP1 PE=1 SV=1" "0.000" "False" "18.733" "10" "4" "12" "4" "466" "52.1" "5.52" "32.57" "4" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00076, Pf02136" "10146" "ENSG00000145907" "G3BP1" "hsa:10146; Q13283; Q5HYE9" "7q11.23 distal copy number variation; HDAC6 interactions in the central nervous system" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "3" "0" "1.050" "1.009" "1.057" "1.042" "0.981" "1.060" "1.099" "1.043" "0.798" "1417.8" "1488.1" "1429.9" "1498.7" "1476.8" "1391.0" "1502.8" "1557.7" "1478.6" "1130.7" "" "" "" "" "" "" "" "" "" "" "750.7" "825.1" "818.9" "690.2" "799.0" "773.7" "884.5" "850.3" "829.5" "1130.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-797188196996991140" "False" "High" "IsMasterProtein" "P15170" "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A OS=Homo sapiens OX=9606 GN=GSPT1 PE=1 SV=1" "0.000" "False" "18.731" "11" "7" "14" "7" "499" "55.7" "5.62" "36.77" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "2935" "ENSG00000103342" "GSPT1" "hsa:2935; J3KQG6; P15170; Q96GF2" "" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "4" "0" "0.952" "0.933" "0.971" "1.030" "0.971" "1.025" "0.964" "1.007" "0.620" "1255.8" "1195.5" "1171.6" "1219.2" "1293.8" "1219.5" "1287.0" "1210.1" "1264.2" "778.5" "" "" "" "" "" "" "" "" "" "" "664.9" "662.8" "671.0" "561.5" "700.0" "678.4" "757.4" "660.5" "709.2" "778.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4154359228263867930" "False" "High" "IsMasterProtein" "P46781" "Small ribosomal subunit protein uS4 OS=Homo sapiens OX=9606 GN=RPS9 PE=1 SV=3" "0.000" "False" "18.728" "12" "3" "4" "3" "194" "22.6" "10.65" "14.01" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00163, Pf01479" "6203" "ENSG00000170889; ENSG00000274005; ENSG00000274626; ENSG00000274646; ENSG00000274950; ENSG00000275323; ENSG00000277079; ENSG00000277359; ENSG00000278081; ENSG00000278270" "RPS9" "A9C4C1; hsa:6203; P46781; Q4QRK7; Q9BVZ0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "20" "0" "1.078" "1.211" "1.241" "1.191" "1.078" "1.156" "1.355" "1.193" "1.289" "132.6" "142.9" "160.7" "164.6" "158.0" "143.0" "153.4" "179.7" "158.3" "171.0" "" "" "" "" "" "" "" "" "" "" "70.2" "79.3" "92.0" "75.8" "85.5" "79.5" "90.3" "98.1" "88.8" "171.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4786951349264090061" "False" "High" "IsMasterProtein" "Q9P2I0" "Cleavage and polyadenylation specificity factor subunit 2 OS=Homo sapiens OX=9606 GN=CPSF2 PE=1 SV=2" "0.000" "False" "18.720" "11" "7" "8" "7" "782" "88.4" "5.11" "16.30" "7" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf07521, Pf10996, Pf13299, Pf16661" "53981" "ENSG00000165934" "CPSF2" "B3KME1; hsa:53981; Q6NSJ1; Q9H3W7; Q9P2I0" "mRNA processing" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "6" "0" "0.967" "0.986" "1.098" "1.129" "1.107" "1.223" "0.989" "1.192" "3.274" "582.1" "562.7" "573.9" "639.0" "657.5" "644.6" "711.9" "575.9" "693.7" "1905.6" "" "" "" "" "" "" "" "" "" "" "308.2" "312.0" "328.7" "294.3" "355.7" "358.6" "419.0" "314.4" "389.2" "1905.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1817111684576735415" "False" "High" "IsMasterProtein" "O15511" "Actin-related protein 2/3 complex subunit 5 OS=Homo sapiens OX=9606 GN=ARPC5 PE=1 SV=3" "0.000" "False" "18.703" "26" "4" "6" "4" "151" "16.3" "5.67" "18.96" "4" "cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf04699" "10092" "ENSG00000162704" "ARPC5" "A6NEC4; hsa:10092; O15511; Q6PG42" "Pathogenic Escherichia coli infection; Regulation of actin cytoskeleton" "Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; EPHB-mediated forward signaling" "8" "0" "1.133" "1.145" "1.139" "1.057" "0.953" "1.101" "1.241" "1.160" "0.662" "790.3" "895.7" "904.6" "900.0" "835.3" "753.3" "869.8" "980.7" "917.1" "523.1" "" "" "" "" "" "" "" "" "" "" "418.5" "496.6" "518.1" "414.5" "451.9" "419.0" "511.9" "535.3" "514.4" "523.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8547587141624532923" "False" "High" "IsMasterProtein" "Q9UKV8" "Protein argonaute-2 OS=Homo sapiens OX=9606 GN=AGO2 PE=1 SV=3" "0.000" "False" "18.691" "7" "6" "9" "4" "859" "97.1" "9.19" "23.52" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02170, Pf02171, Pf08699, Pf16486, Pf16487, Pf16488" "27161" "ENSG00000123908" "AGO2" "Q8TCZ5; Q8WV58; Q96ID1; Q9UKV8" "exRNA mechanism of action and biogenesis; Fragile X syndrome; Male infertility; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "Transcriptional regulation by small RNAs; MAPK6/MAPK4 signaling; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Regulation of RUNX1 Expression and Activity; Small interfering RNA (siRNA) biogenesis; M-decay: degradation of maternal mRNAs by maternally stored factors; TP53 Regulates Metabolic Genes; Ca2+ pathway; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; MicroRNA (miRNA) biogenesis; Nuclear events stimulated by ALK signaling in cancer; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "24" "1" "0.972" "0.995" "0.998" "0.975" "1.011" "1.043" "1.052" "0.981" "0.775" "866.2" "841.8" "861.9" "864.5" "844.9" "875.7" "903.6" "911.0" "849.9" "671.7" "" "" "" "" "" "" "" "" "" "" "458.7" "466.7" "493.6" "398.1" "457.1" "487.1" "531.8" "497.3" "476.8" "671.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7032726270839277036" "False" "High" "IsMasterProtein" "P27144" "Adenylate kinase 4, mitochondrial OS=Homo sapiens OX=9606 GN=AK4 PE=1 SV=1" "0.000" "False" "18.689" "23" "5" "7" "5" "223" "25.3" "8.40" "22.03" "5" "other metabolic processes;stress response;other biological processes" "mitochondrion;other cell component" "kinase activity;other molecular function" "Pf00406, Pf05191" "205" "ENSG00000162433" "AK4" "B2R927; D3DQ62; hsa:205; P27144; Q6IBH4; Q6NXQ5; Q8IUU9" "CCL18 signaling pathway" "Interconversion of nucleotide di- and triphosphates" "2" "0" "0.969" "1.006" "1.001" "0.986" "0.955" "0.875" "0.890" "0.865" "0.592" "1227.3" "1188.7" "1234.0" "1228.7" "1210.6" "1172.2" "1073.8" "1092.1" "1061.3" "726.0" "" "" "" "" "" "" "" "" "" "" "649.8" "659.0" "706.7" "565.9" "655.0" "652.0" "631.9" "596.1" "595.4" "726.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1819125433981479748" "False" "High" "IsMasterProtein" "Q15404" "Ras suppressor protein 1 OS=Homo sapiens OX=9606 GN=RSU1 PE=1 SV=3" "0.000" "False" "18.688" "22" "7" "11" "7" "277" "31.5" "8.65" "23.87" "7" "signal transduction;other biological processes" "cytosol;other cell component" "" "Pf13855" "6251" "ENSG00000148484" "RSU1" "A8KA46; D3DRU3; hsa:6251; Q15404; Q6FI17" "" "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "1" "0" "1.046" "1.095" "1.279" "1.169" "1.124" "1.112" "1.052" "1.071" "1.291" "418.6" "438.0" "458.4" "535.3" "489.2" "470.6" "465.5" "440.2" "448.6" "540.5" "" "" "" "" "" "" "" "" "" "" "221.7" "242.9" "262.5" "246.5" "264.7" "261.8" "273.9" "240.3" "251.6" "540.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "777273144622755670" "False" "High" "IsMasterProtein" "P51649" "Succinate-semialdehyde dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH5A1 PE=1 SV=2" "0.000" "False" "18.682" "9" "5" "6" "5" "535" "57.2" "8.28" "17.89" "5" "cell-cell signaling;other metabolic processes;developmental processes" "mitochondrion;other cell component" "other molecular function" "Pf00171" "7915" "ENSG00000112294" "ALDH5A1" "B2RD26; G5E949; hsa:7915; P51649; Q546H9; Q8N3W6" "Fragile X syndrome" "Degradation of GABA" "2" "0" "0.925" "0.924" "1.067" "1.004" "1.065" "0.994" "1.016" "0.889" "0.574" "462.4" "427.6" "427.2" "493.3" "464.4" "492.6" "459.6" "469.7" "411.2" "265.2" "" "" "" "" "" "" "" "" "" "" "244.8" "237.1" "244.6" "227.2" "251.2" "274.0" "270.5" "256.4" "230.7" "265.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3208600518816650541" "False" "High" "IsMasterProtein" "Q96IU4" "Putative protein-lysine deacylase ABHD14B OS=Homo sapiens OX=9606 GN=ABHD14B PE=1 SV=1" "0.000" "False" "18.681" "19" "4" "8" "4" "210" "22.3" "6.40" "23.06" "4" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12697" "84836" "ENSG00000114779" "ABHD14B" "hsa:84836; Q86VK8; Q8N8W5; Q96IU4" "" "Cytosolic sulfonation of small molecules" "1" "0" "1.016" "0.976" "0.902" "1.039" "1.029" "0.937" "1.030" "1.024" "0.818" "785.1" "797.5" "766.1" "707.9" "815.9" "807.8" "735.4" "808.9" "804.3" "642.3" "" "" "" "" "" "" "" "" "" "" "415.7" "442.2" "438.7" "326.0" "441.4" "449.3" "432.8" "441.5" "451.2" "642.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7326537803977903766" "False" "High" "IsMasterProtein" "P02786" "Transferrin receptor protein 1 OS=Homo sapiens OX=9606 GN=TFRC PE=1 SV=2" "0.000" "False" "18.671" "7" "4" "6" "4" "760" "84.8" "6.61" "17.66" "4" "stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf02225, Pf04253, Pf04389" "7037" "ENSG00000072274" "TFRC" "D3DXB0; hsa:7037; P02786; Q1HE24; Q59G55; Q9UCN0; Q9UCU5; Q9UDF9; Q9UK21" "Iron metabolism in placenta; Ferroptosis; 3q29 copy number variation syndrome; Iron metabolism disorders" "RHOC GTPase cycle; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; Golgi Associated Vesicle Biogenesis; RND1 GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; Transferrin endocytosis and recycling; RHOH GTPase cycle" "21" "0" "1.155" "1.205" "1.149" "1.134" "1.288" "1.197" "1.258" "1.086" "0.847" "260.1" "300.4" "313.4" "298.8" "294.9" "335.0" "311.3" "327.1" "282.4" "220.3" "" "" "" "" "" "" "" "" "" "" "137.7" "166.5" "179.5" "137.6" "159.6" "186.4" "183.2" "178.5" "158.4" "220.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5564362200897381814" "False" "High" "IsMasterProtein" "Q9P2N5" "RNA-binding protein 27 OS=Homo sapiens OX=9606 GN=RBM27 PE=1 SV=2" "0.000" "False" "18.649" "5" "6" "6" "5" "1060" "118.6" "9.19" "15.39" "6" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00076, Pf00642, Pf01480" "54439" "ENSG00000091009" "RBM27" "hsa:54439; Q8IYW9; Q9P2N5" "" "" "0" "0" "0.896" "0.965" "0.961" "0.971" "0.949" "1.178" "1.051" "1.051" "1.350" "275.3" "246.6" "265.6" "264.7" "267.4" "261.4" "324.4" "289.3" "289.5" "371.6" "" "" "" "" "" "" "" "" "" "" "145.8" "136.7" "152.1" "121.9" "144.7" "145.4" "190.9" "157.9" "162.4" "371.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1687384969150092260" "False" "High" "IsMasterProtein" "Q96B97" "SH3 domain-containing kinase-binding protein 1 OS=Homo sapiens OX=9606 GN=SH3KBP1 PE=1 SV=2" "0.000" "False" "18.643" "11" "6" "7" "6" "665" "73.1" "6.62" "16.54" "6" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf14604" "30011" "ENSG00000147010" "SH3KBP1" "B7Z1D5; hsa:30011; Q5JPT4; Q5JPT5; Q8IWX6; Q8IX98; Q96B97; Q96RN4; Q9NYR0" "EGF/EGFR signaling pathway" "Potential therapeutics for SARS; Cargo recognition for clathrin-mediated endocytosis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Reelin signalling pathway" "9" "0" "1.036" "0.934" "1.334" "1.144" "1.138" "1.334" "1.299" "1.209" "1.819" "192.0" "198.8" "179.2" "256.0" "219.6" "218.5" "256.1" "249.3" "232.2" "349.2" "" "" "" "" "" "" "" "" "" "" "101.6" "110.2" "102.6" "117.9" "118.8" "121.5" "150.7" "136.1" "130.2" "349.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8162183631045646946" "False" "High" "IsMasterProtein" "Q01085" "Nucleolysin TIAR OS=Homo sapiens OX=9606 GN=TIAL1 PE=1 SV=1" "0.000" "False" "18.595" "11" "4" "5" "3" "375" "41.6" "7.74" "14.39" "4" "cell cycle OR cell proliferation;stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "7073" "ENSG00000151923" "TIAL1" "A8K3T0; A8K4L9; hsa:7073; Q01085" "" "FGFR2 alternative splicing" "1" "1" "1.003" "1.054" "0.999" "0.892" "0.959" "0.908" "1.056" "0.899" "0.733" "1057.3" "1060.1" "1114.7" "1056.3" "942.6" "1014.1" "959.9" "1116.9" "950.7" "774.7" "" "" "" "" "" "" "" "" "" "" "559.8" "587.8" "638.4" "486.5" "510.0" "564.1" "564.9" "609.7" "533.3" "774.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3953719107085229180" "False" "High" "IsMasterProtein" "Q9Y6K9" "NF-kappa-B essential modulator OS=Homo sapiens OX=9606 GN=IKBKG PE=1 SV=2" "0.000" "False" "18.591" "12" "6" "6" "6" "419" "48.2" "5.71" "17.35" "6" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf11577, Pf16516, Pf18414" "8517" "ENSG00000269335" "IKBKG" "hsa:8517; Q7LBY6; Q7Z7F1; Q9Y6K9" "Nucleotide-binding oligomerization domain (NOD) pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; ATM signaling in development and disease ; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Hepatitis B infection; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Network map of SARS-CoV-2 signaling pathway; Acute myeloid leukemia; T-cell receptor signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway" "CLEC7A (Dectin-1) signaling; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Ub-specific processing proteases; SARS-CoV-2 activates/modulates innate and adaptive immune responses; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; activated TAK1 mediates p38 MAPK activation; Ovarian tumor domain proteases; PKR-mediated signaling; RIP-mediated NFkB activation via ZBP1; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; SUMOylation of immune response proteins" "76" "0" "1.087" "1.108" "1.133" "1.090" "1.001" "1.139" "1.112" "1.131" "1.149" "898.4" "976.7" "995.5" "1017.6" "979.6" "899.2" "1023.5" "998.8" "1015.7" "1032.5" "" "" "" "" "" "" "" "" "" "" "475.7" "541.5" "570.1" "468.6" "530.0" "500.2" "602.3" "545.2" "569.8" "1032.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1738440604026587204" "False" "High" "IsMasterProtein" "P60510" "Serine/threonine-protein phosphatase 4 catalytic subunit OS=Homo sapiens OX=9606 GN=PPP4C PE=1 SV=1" "0.000" "False" "18.589" "8" "2" "4" "2" "307" "35.1" "5.06" "13.30" "2" "DNA metabolism;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00149" "5531" "ENSG00000149923" "PPP4C" "hsa:5531; P33172; P60510" "16p11.2 proximal deletion syndrome" "Processing of DNA double-strand break ends" "2" "0" "0.864" "0.886" "0.952" "0.974" "0.873" "1.000" "0.951" "0.924" "0.589" "523.4" "452.0" "463.9" "498.3" "510.0" "457.1" "523.5" "497.5" "483.4" "308.5" "" "" "" "" "" "" "" "" "" "" "277.2" "250.6" "265.7" "229.5" "275.9" "254.2" "308.1" "271.6" "271.2" "308.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1319936172901890664" "False" "High" "IsMasterProtein" "P45973" "Chromobox protein homolog 5 OS=Homo sapiens OX=9606 GN=CBX5 PE=1 SV=1" "0.000" "False" "18.580" "23" "4" "5" "4" "191" "22.2" "5.86" "10.22" "4" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00385, Pf01393" "23468" "ENSG00000094916" "CBX5" "B2R8T9; hsa:23468; P45973" "Effect of progerin on genes involved in progeria; 22q11.2 copy number variation syndrome" "SUMOylation of chromatin organization proteins; Transcriptional Regulation by E2F6; Factors involved in megakaryocyte development and platelet production" "5" "0" "0.939" "1.117" "1.113" "1.048" "1.114" "1.086" "1.141" "1.066" "1.299" "418.2" "392.6" "466.9" "465.5" "438.2" "465.9" "454.1" "477.4" "445.8" "543.5" "" "" "" "" "" "" "" "" "" "" "221.4" "217.7" "267.4" "214.4" "237.1" "259.2" "267.3" "260.6" "250.1" "543.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3668723528538727638" "False" "High" "IsMasterProtein" "Q9UDT6" "CAP-Gly domain-containing linker protein 2 OS=Homo sapiens OX=9606 GN=CLIP2 PE=1 SV=1" "0.000" "False" "18.575" "5" "6" "7" "3" "1046" "115.8" "6.73" "20.27" "6" "cell organization and biogenesis" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf01302" "7461" "ENSG00000106665" "CLIP2" "hsa:7461; O14527; O43611; Q9UDT6" "7q11.23 copy number variation syndrome" "" "1" "0" "1.031" "1.051" "0.987" "1.060" "1.023" "1.150" "0.974" "1.031" "1.225" "624.8" "644.4" "656.5" "616.7" "662.5" "639.5" "718.6" "608.5" "644.2" "765.1" "" "" "" "" "" "" "" "" "" "" "330.8" "357.3" "376.0" "284.0" "358.5" "355.7" "422.9" "332.2" "361.4" "765.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6132827760965537069" "False" "High" "IsMasterProtein" "Q7Z3D6" "D-glutamate cyclase, mitochondrial OS=Homo sapiens OX=9606 GN=DGLUCY PE=1 SV=2" "0.000" "False" "18.574" "8" "5" "6" "5" "616" "66.4" "6.79" "16.08" "5" "other metabolic processes" "mitochondrion" "other molecular function" "Pf07286, Pf14336" "80017" "ENSG00000133943" "DGLUCY" "B3KUI7; hsa:80017; Q7Z3D6; Q86SW3; Q86SX8; Q86SX9; Q86T08; Q86TV5; Q96GW5; Q9H7G0; Q9H8Y9; Q9H9W6" "" "" "0" "0" "0.985" "0.954" "1.054" "1.040" "0.999" "1.022" "0.903" "0.929" "0.729" "508.4" "501.0" "485.0" "535.6" "528.7" "508.1" "519.4" "459.3" "472.2" "370.5" "" "" "" "" "" "" "" "" "" "" "269.2" "277.8" "277.8" "246.7" "286.0" "282.6" "305.7" "250.7" "264.9" "370.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7031077161766424227" "False" "High" "IsMasterProtein" "Q4V328" "GRIP1-associated protein 1 OS=Homo sapiens OX=9606 GN=GRIPAP1 PE=1 SV=2" "0.000" "False" "18.565" "7" "6" "7" "6" "841" "95.9" "5.11" "12.53" "6" "transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "" "56850" "ENSG00000068400; ENSG00000292219" "GRIPAP1" "A6NL78; hsa:56850; Q3MJ75; Q4V327; Q4V328; Q4V330; Q5HYG1; Q6N046; Q96DH8; Q9NQ43; Q9ULQ3" "" "" "0" "0" "1.133" "1.019" "1.239" "1.148" "1.110" "1.577" "1.456" "1.458" "1.270" "249.5" "282.6" "254.3" "309.0" "286.4" "276.8" "393.4" "363.2" "363.8" "316.7" "" "" "" "" "" "" "" "" "" "" "132.1" "156.7" "145.6" "142.3" "155.0" "154.0" "231.5" "198.3" "204.1" "316.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3527140061799616806" "False" "High" "IsMasterProtein" "Q9BW19" "Kinesin-like protein KIFC1 OS=Homo sapiens OX=9606 GN=KIFC1 PE=1 SV=2" "0.000" "False" "18.563" "9" "5" "5" "5" "673" "73.7" "8.98" "13.68" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cytoplasmic organelle" "cytoskeletal activity;other molecular function" "Pf00225" "3833" "ENSG00000204197; ENSG00000233450; ENSG00000237649" "KIFC1" "hsa:3833; O60887; Q14834; Q4KMP0; Q5SU09; Q6GMS7; Q6P4A5; Q9BW19; Q9UQP7" "" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "2" "0" "0.982" "1.059" "1.258" "1.138" "1.181" "1.060" "0.876" "1.001" "4.018" "95.7" "94.0" "101.4" "120.4" "109.0" "113.0" "101.5" "83.8" "95.8" "384.6" "" "" "" "" "" "" "" "" "" "" "50.7" "52.1" "58.1" "55.5" "59.0" "62.9" "59.7" "45.8" "53.7" "384.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4061147392346931585" "False" "High" "IsMasterProtein" "P61006" "Ras-related protein Rab-8A OS=Homo sapiens OX=9606 GN=RAB8A PE=1 SV=1" "0.000" "False" "18.556" "20" "5" "13" "2" "207" "23.7" "9.07" "33.97" "5" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "4218" "ENSG00000167461" "RAB8A" "B4DEK7; hsa:4218; P24407; P61006; Q6FHV5" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape; Joubert syndrome" "RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Anchoring of the basal body to the plasma membrane; VxPx cargo-targeting to cilium; TBC/RABGAPs" "10" "1" "1.003" "0.989" "0.923" "0.982" "1.063" "0.890" "0.996" "1.010" "0.620" "1379.5" "1384.1" "1364.8" "1273.1" "1355.3" "1466.4" "1227.8" "1374.5" "1393.7" "855.1" "" "" "" "" "" "" "" "" "" "" "730.4" "767.4" "781.6" "586.3" "733.2" "815.7" "722.6" "750.3" "781.9" "855.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4002494153914850513" "False" "High" "IsMasterProtein" "P51665" "26S proteasome non-ATPase regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PSMD7 PE=1 SV=2" "0.000" "False" "18.540" "13" "4" "8" "4" "324" "37.0" "6.77" "21.47" "4" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01398, Pf13012" "5713" "ENSG00000103035" "PSMD7" "D3DWS9; hsa:5713; P51665; Q6PKI2; Q96E97" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "Neutrophil degranulation; Regulation of expression of SLITs and ROBOs; Orc1 removal from chromatin; Assembly of the pre-replicative complex; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "65" "0" "0.952" "0.983" "1.184" "1.015" "1.093" "0.979" "1.010" "0.975" "0.990" "550.0" "523.4" "540.5" "651.4" "558.2" "601.0" "538.2" "555.3" "536.4" "544.4" "" "" "" "" "" "" "" "" "" "" "291.2" "290.2" "309.5" "300.0" "302.0" "334.3" "316.8" "303.1" "300.9" "544.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "350297391460659300" "False" "High" "IsMasterProtein" "Q96CT7" "Coiled-coil domain-containing protein 124 OS=Homo sapiens OX=9606 GN=CCDC124 PE=1 SV=1" "0.000" "False" "18.538" "19" "5" "7" "5" "223" "25.8" "9.54" "21.47" "5" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf06244" "115098" "ENSG00000007080" "CCDC124" "hsa:115098; Q96CT7" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.089" "1.102" "1.469" "1.242" "1.235" "1.586" "1.539" "1.556" "0.517" "785.7" "855.8" "866.1" "1154.3" "975.9" "970.3" "1245.8" "1209.0" "1222.3" "405.8" "" "" "" "" "" "" "" "" "" "" "416.0" "474.5" "496.0" "531.6" "528.0" "539.7" "733.2" "659.9" "685.7" "405.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4440624783436864340" "False" "High" "IsMasterProtein" "P01911" "HLA class II histocompatibility antigen, DRB1 beta chain OS=Homo sapiens OX=9606 GN=HLA-DRB1 PE=1 SV=2" "0.000" "False" "18.518" "23" "6" "6" "4" "266" "29.9" "7.74" "15.62" "6" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00969, Pf07654" "3123" "ENSG00000196126" "HLA-DRB1" "A0MWF2; A0N0W1; A2ICT1; A2TGX3; A4F5N0; A4ZXA5; A4ZXA6; A4ZY86; A5H000; A5HKN8; A7DZP9; A7LA26; A7UHG2; A7X5B1; A7X5B7; A7X5E0; A7X5E6; A7X5H8; A7X5J4; A7X5K7; A8K098; A8YQE9; A9JPG0; B0BK85; B0LUZ6; B0UYW1; B1GWE7; B2CR03; B2LVF9; B2NJ29; B2ZCY1; B3VTP8; B3VTQ3; B5A8Y2; B5A8Y3; B5B8U0; B5B9V5; B5B9V6; B5LZ25; B5QSK8; B6VCX2; B6VEL9; B7UDB2; B9VRA4; B9X248; C0LAB5; hsa:3123; O02876; O02930; O19585; O19717; O19718; O19739; O19788; O46699; O46793; O46872; O62869; O62889; O77969; O78047; O78210; O98212; P01911; P01912; P01914; P04229; P13758; P13759; P13760; P13761; P20039; P79545; Q06662; Q0PGR5; Q0PQ39; Q14280; Q14QT2; Q155F7; Q19AF2; Q19K86; Q1AP33; Q1G0Z9; Q1JRP3; Q1KLJ6; Q27PR6; Q27PR7; Q29673; Q29720; Q29722; Q29734; Q29770; Q29771; Q29772; Q29790; Q29792; Q29800; Q29806; Q29833; Q29874; Q29875; Q29886; Q29968; Q29974; Q29975; Q2A120; Q2HZE5; Q2L9H4; Q2LE76; Q2MF40; Q2MJA6; Q2MZ92; Q2VQU1; Q2YHQ2; Q30006; Q30108; Q30112; Q30115; Q30116; Q30117; Q30120; Q30134; Q30142; Q30145; Q30149; Q30159; Q30166; Q30167; Q30200; Q307W5; Q31636; Q32MY7; Q3HUP9; Q3KTM1; Q3LA84; Q3LA87; Q3LA88; Q3LA89; Q3LA90; Q3LA91; Q3LA92; Q3LA93; Q3LA94; Q3LA95; Q3LA96; Q3LA97; Q3LA98; Q3LA99; Q3LAA0; Q3LAA1; Q3LAA2; Q3MQ60; Q3T919; Q4PRC3; Q4PRC5; Q4VZY7; Q53IG1; Q56FN9; Q56FP1; Q56FP2; Q56FP3; Q58F52; Q5BM92; Q5EER6; Q5K3W2; Q5NDB9; Q5U9W6; Q5UBA2; Q5UT58; Q5W3L4; Q5Y7A7; Q5Y7B0; Q5Y7B9; Q5Y7E9; Q5Y7G0; Q683P7; Q6REE2; Q6T865; Q6U387; Q701T1; Q70GL2; Q70Q85; Q768U2; Q768U4; Q7M2H4; Q7YNY9; Q7YP03; Q7YP04; Q7YQ26; Q7YQA3; Q7YQA5; Q860D8; Q860D9; Q860E5; Q860H8; Q860S0; Q860Z3; Q861G6; Q861H0; Q861H4; Q861H5; Q861H7; Q861H8; Q8HWQ6; Q8MH59; Q8MH60; Q8WLU3; Q8WMA0; Q95348; Q95383; Q95389; Q95461; Q95HK1; Q95HL0; Q95HL1; Q95IE3; Q95IG2; Q95IT6; Q96HZ9; Q9BCL7; Q9BCP0; Q9BCP1; Q9BCP2; Q9BCP5; Q9BD21; Q9BD33; Q9BD40; Q9GIK5; Q9GIL5; Q9GIL6; Q9GIP3; Q9GIX8; Q9GIX9; Q9GIY0; Q9GIY1; Q9GIY2; Q9GIY3; Q9GIY4; Q9GJ25; Q9GJ56; Q9GJ57; Q9GJ58; Q9GJ60; Q9GJF8; Q9GJF9; Q9GJG0; Q9MXZ0; Q9MXZ5; Q9MY13; Q9MY45; Q9MY56; Q9MYF5; Q9TPB6; Q9TPW1; Q9TPW3; Q9TPW9; Q9TPX4; Q9TQ37; Q9TQ91; Q9TQE0; Q9UBY1; Q9UIM9; Q9UIN0; Q9XRX1; Q9XRY4; Q9XRY5; Q9Y453; Q9Y4H7" "Allograft rejection; Vitamin D receptor pathway; Ebola virus infection in host; Cancer immunotherapy by PD-1 blockade; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Genes associated with the development of rheumatoid arthritis; Network map of SARS-CoV-2 signaling pathway; Cell interactions of the pancreatic cancer microenvironment; Cytokines and inflammatory response; Primary ovarian insufficiency" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "17" "2" "1.040" "1.132" "0.968" "1.003" "1.084" "0.975" "1.140" "0.953" "0.518" "1005.2" "1045.4" "1138.0" "973.2" "1008.4" "1089.5" "979.5" "1146.0" "958.4" "521.2" "" "" "" "" "" "" "" "" "" "" "532.2" "579.6" "651.7" "448.2" "545.6" "606.0" "576.5" "625.5" "537.6" "521.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7112262159952005485" "False" "High" "IsMasterProtein" "Q5T440" "Putative transferase CAF17, mitochondrial OS=Homo sapiens OX=9606 GN=IBA57 PE=1 SV=1" "0.000" "False" "18.506" "12" "4" "4" "4" "356" "38.1" "9.83" "14.45" "4" "cell organization and biogenesis;other metabolic processes" "mitochondrion" "other molecular function" "" "200205" "ENSG00000181873" "IBA57" "hsa:200205; Q5T440" "" "" "0" "0" "1.034" "0.997" "1.061" "1.109" "1.001" "0.997" "1.060" "0.912" "0.755" "361.1" "373.3" "359.9" "383.0" "400.3" "361.6" "360.2" "382.9" "329.3" "272.7" "" "" "" "" "" "" "" "" "" "" "191.2" "207.0" "206.1" "176.4" "216.6" "201.1" "212.0" "209.0" "184.7" "272.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "59184659773015562" "False" "High" "IsMasterProtein" "Q969H8" "Myeloid-derived growth factor OS=Homo sapiens OX=9606 GN=MYDGF PE=1 SV=1" "0.000" "False" "18.493" "22" "5" "10" "5" "173" "18.8" "6.68" "15.00" "5" "developmental processes;other biological processes" "non-structural extracellular;ER/Golgi" "" "Pf10572" "56005" "ENSG00000074842" "MYDGF" "D6W628; hsa:56005; O75256; O75272; Q969H8; Q9BTK7; Q9NP69" "" "XBP1(S) activates chaperone genes" "1" "0" "1.006" "0.924" "0.968" "1.090" "1.033" "0.929" "1.077" "0.919" "0.633" "268.3" "270.0" "247.9" "259.7" "292.3" "277.1" "249.2" "288.9" "246.4" "169.7" "" "" "" "" "" "" "" "" "" "" "142.0" "149.7" "142.0" "119.6" "158.2" "154.1" "146.7" "157.7" "138.2" "169.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1307074189875800146" "False" "High" "IsMasterProtein" "O14732" "Inositol monophosphatase 2 OS=Homo sapiens OX=9606 GN=IMPA2 PE=1 SV=1" "0.000" "False" "18.446" "16" "5" "5" "5" "288" "31.3" "6.61" "13.41" "5" "other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00459" "3613" "ENSG00000141401" "IMPA2" "B0YJ29; hsa:3613; O14732; Q9UJT3" "" "Synthesis of IP2, IP, and Ins in the cytosol" "1" "0" "1.017" "0.984" "1.024" "1.021" "0.980" "1.014" "0.978" "1.040" "0.567" "264.9" "269.3" "260.7" "271.2" "270.4" "259.5" "268.6" "259.0" "275.6" "150.1" "" "" "" "" "" "" "" "" "" "" "140.3" "149.3" "149.3" "124.9" "146.3" "144.4" "158.1" "141.4" "154.6" "150.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4576818443980197018" "False" "High" "IsMasterProtein" "P52292" "Importin subunit alpha-1 OS=Homo sapiens OX=9606 GN=KPNA2 PE=1 SV=1" "0.000" "False" "18.431" "9" "4" "7" "4" "529" "57.8" "5.40" "22.54" "4" "DNA metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3838" "ENSG00000182481" "KPNA2" "B9EJD6; hsa:3838; P52292; Q53YE3; Q6NVW7; Q9BRU5" "" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Estrogen-dependent gene expression; SARS-CoV-1 activates/modulates innate immune responses; Sensing of DNA Double Strand Breaks; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde" "8" "0" "1.407" "1.080" "1.213" "1.711" "0.998" "1.272" "1.085" "1.554" "1.695" "32.1" "45.2" "34.7" "39.0" "54.9" "32.0" "40.8" "34.8" "49.9" "54.4" "" "" "" "" "" "" "" "" "" "" "17.0" "25.0" "19.9" "17.9" "29.7" "17.8" "24.0" "19.0" "28.0" "54.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1302469806401564563" "False" "High" "IsMasterProtein" "P49748" "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADVL PE=1 SV=1" "0.000" "False" "18.406" "9" "6" "8" "6" "655" "70.3" "8.75" "21.07" "6" "other metabolic processes;stress response;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00441, Pf02770, Pf02771, Pf21343" "37" "ENSG00000072778" "ACADVL" "B4DEB6; F5H2A9; hsa:37; O76056; P49748; Q8WUL0" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation" "XBP1(S) activates chaperone genes; Beta oxidation of palmitoyl-CoA to myristoyl-CoA" "4" "0" "1.093" "1.012" "1.138" "1.094" "1.099" "1.068" "1.088" "1.031" "0.668" "712.5" "778.5" "720.8" "810.8" "779.4" "782.9" "760.8" "774.9" "734.7" "475.8" "" "" "" "" "" "" "" "" "" "" "377.3" "431.6" "412.8" "373.4" "421.7" "435.5" "447.7" "423.0" "412.1" "475.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8470194220236547975" "False" "High" "IsMasterProtein" "Q5TBB1" "Ribonuclease H2 subunit B OS=Homo sapiens OX=9606 GN=RNASEH2B PE=1 SV=1" "0.000" "False" "18.403" "18" "5" "6" "5" "312" "35.1" "9.13" "14.57" "5" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf09468, Pf17745" "79621" "ENSG00000136104" "RNASEH2B" "G3XAJ1; hsa:79621; Q05DR2; Q5TBB1; Q6PK48; Q9HAF7" "" "" "0" "0" "1.052" "1.004" "1.003" "0.991" "1.054" "0.833" "0.298" "0.856" "6.864" "270.2" "284.2" "271.2" "270.9" "267.9" "284.8" "225.0" "80.6" "231.2" "1854.4" "" "" "" "" "" "" "" "" "" "" "143.1" "157.6" "155.3" "124.8" "144.9" "158.4" "132.4" "44.0" "129.7" "1854.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-997186877852076993" "False" "High" "IsMasterProtein" "Q9NYL9" "Tropomodulin-3 OS=Homo sapiens OX=9606 GN=TMOD3 PE=1 SV=1" "0.000" "False" "18.392" "13" "5" "5" "5" "352" "39.6" "5.19" "14.17" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton" "cytoskeletal activity" "Pf03250" "29766" "ENSG00000138594" "TMOD3" "B2R6G7; hsa:29766; Q9NT43; Q9NYL9; Q9NZR0" "VEGFA-VEGFR2 signaling" "RND3 GTPase cycle; Striated Muscle Contraction; RHOBTB2 GTPase cycle" "4" "0" "0.967" "1.062" "0.961" "1.058" "0.990" "1.031" "0.805" "1.196" "4.681" "245.4" "237.2" "260.7" "235.9" "259.7" "243.0" "253.0" "197.6" "293.6" "1149.0" "" "" "" "" "" "" "" "" "" "" "130.0" "131.5" "149.3" "108.7" "140.5" "135.2" "148.9" "107.9" "164.7" "1149.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "240711896831941506" "False" "High" "IsMasterProtein" "P23396" "Small ribosomal subunit protein uS3 OS=Homo sapiens OX=9606 GN=RPS3 PE=1 SV=2" "0.000" "False" "18.391" "26" "7" "9" "7" "243" "26.7" "9.66" "23.32" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00189, Pf07650" "6188" "ENSG00000149273" "RPS3" "B2R7N5; hsa:6188; J3KN86; P23396; Q498B5; Q8NI95" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.242" "1.250" "1.414" "1.343" "1.388" "1.500" "1.292" "1.568" "2.215" "477.4" "592.8" "596.8" "674.9" "641.3" "662.6" "716.0" "616.7" "748.6" "1057.2" "" "" "" "" "" "" "" "" "" "" "252.8" "328.6" "341.8" "310.8" "347.0" "368.6" "421.4" "336.6" "419.9" "1057.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8542796064985296864" "False" "High" "IsMasterProtein" "Q969Y2" "tRNA modification GTPase GTPBP3, mitochondrial OS=Homo sapiens OX=9606 GN=GTPBP3 PE=1 SV=2" "0.000" "False" "18.372" "10" "5" "6" "5" "492" "52.0" "6.48" "16.34" "5" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf01926, Pf10396, Pf12631" "84705" "ENSG00000130299" "GTPBP3" "A6NFH1; A6NIG5; A6NKR4; A8K7B4; B7Z4V8; hsa:84705; Q8TCY6; Q8WUW9; Q969G4; Q969Y2; Q9BX61" "" "tRNA modification in the mitochondrion" "1" "0" "0.883" "0.819" "1.097" "0.955" "0.907" "0.980" "0.906" "0.819" "0.565" "185.9" "164.2" "152.3" "203.8" "177.6" "168.6" "182.2" "168.4" "152.2" "105.0" "" "" "" "" "" "" "" "" "" "" "98.4" "91.0" "87.2" "93.9" "96.1" "93.8" "107.2" "91.9" "85.4" "105.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4921032794514216116" "False" "High" "IsMasterProtein" "Q8WXX5" "DnaJ homolog subfamily C member 9 OS=Homo sapiens OX=9606 GN=DNAJC9 PE=1 SV=1" "0.000" "False" "18.370" "19" "4" "7" "4" "260" "29.9" "5.73" "23.22" "4" "cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00226" "23234" "ENSG00000213551" "DNAJC9" "B2RMW6; hsa:23234; Q8WXX5" "" "" "0" "0" "1.024" "0.910" "0.939" "0.883" "0.866" "1.145" "1.132" "1.203" "1.238" "332.0" "340.1" "302.2" "311.6" "293.3" "287.5" "380.2" "375.9" "399.4" "410.8" "" "" "" "" "" "" "" "" "" "" "175.8" "188.6" "173.1" "143.5" "158.7" "159.9" "223.7" "205.2" "224.1" "410.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1008427851520544832" "False" "High" "IsMasterProtein" "Q4KMP7" "TBC1 domain family member 10B OS=Homo sapiens OX=9606 GN=TBC1D10B PE=1 SV=3" "0.000" "False" "18.346" "6" "4" "5" "4" "808" "87.1" "9.19" "14.80" "4" "transport;other biological processes" "plasma membrane;other membranes;cytosol" "enzyme regulator activity" "Pf00566" "26000" "ENSG00000169221" "TBC1D10B" "B9A6L0; hsa:26000; Q4KMP7; Q6IN54; Q6P530; Q71RG7; Q86VC5; Q9H8Z2; Q9NUN6; Q9UFP2" "" "TBC/RABGAPs" "1" "0" "1.056" "1.104" "1.211" "0.975" "1.063" "1.053" "1.077" "0.960" "0.856" "165.2" "174.4" "182.3" "200.0" "161.0" "175.5" "173.9" "177.9" "158.6" "141.4" "" "" "" "" "" "" "" "" "" "" "87.5" "96.7" "104.4" "92.1" "87.1" "97.6" "102.3" "97.1" "88.9" "141.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5539470002617871814" "False" "High" "IsMasterProtein" "Q9P2R7" "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLA2 PE=1 SV=3" "0.000" "False" "18.346" "9" "4" "4" "4" "463" "50.3" "7.42" "12.31" "4" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00549, Pf08442" "8803" "ENSG00000136143" "SUCLA2" "B2RDE7; hsa:8803; O95194; Q5T9Q4; Q5T9Q6; Q9NV21; Q9NVP7; Q9P2R7" "" "Citric acid cycle (TCA cycle)" "1" "0" "0.994" "0.973" "1.036" "1.071" "1.041" "0.938" "0.846" "0.894" "2.679" "259.3" "257.8" "252.3" "268.7" "277.7" "269.9" "243.3" "219.3" "231.8" "694.8" "" "" "" "" "" "" "" "" "" "" "137.3" "142.9" "144.5" "123.7" "150.3" "150.1" "143.2" "119.7" "130.1" "694.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7053379414769105992" "False" "High" "IsMasterProtein" "Q92905" "COP9 signalosome complex subunit 5 OS=Homo sapiens OX=9606 GN=COPS5 PE=1 SV=4" "0.000" "False" "18.302" "17" "5" "5" "5" "334" "37.6" "6.54" "14.96" "5" "protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01398, Pf18323" "10987" "ENSG00000121022" "COPS5" "hsa:10987; O15386; Q6AW95; Q86WQ4; Q92905; Q9BQ17" "TGF-beta signaling pathway" "Formation of TC-NER Pre-Incision Complex; Cargo recognition for clathrin-mediated endocytosis; Neddylation; DNA Damage Recognition in GG-NER" "5" "0" "1.017" "0.988" "1.117" "1.038" "1.014" "1.093" "1.021" "0.927" "0.679" "334.3" "340.0" "330.2" "373.6" "347.1" "339.0" "365.6" "341.3" "310.0" "226.9" "" "" "" "" "" "" "" "" "" "" "177.0" "188.5" "189.1" "172.0" "187.8" "188.6" "215.2" "186.3" "173.9" "226.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1585562482268553685" "False" "High" "IsMasterProtein" "O15372" "Eukaryotic translation initiation factor 3 subunit H OS=Homo sapiens OX=9606 GN=EIF3H PE=1 SV=1" "0.000" "False" "18.289" "11" "3" "4" "3" "352" "39.9" "6.54" "14.84" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01398, Pf19445" "8667" "ENSG00000147677" "EIF3H" "hsa:8667; O15372" "Translation factors; VEGFA-VEGFR2 signaling; Measles virus infection; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "10" "0" "1.043" "0.941" "1.002" "1.074" "0.985" "1.049" "0.990" "1.121" "1.518" "562.7" "586.7" "529.7" "564.0" "604.4" "554.0" "590.5" "557.2" "630.7" "854.2" "" "" "" "" "" "" "" "" "" "" "297.9" "325.3" "303.3" "259.7" "327.0" "308.1" "347.5" "304.1" "353.8" "854.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6856624260157841827" "False" "High" "IsMasterProtein" "O60256" "Phosphoribosyl pyrophosphate synthase-associated protein 2 OS=Homo sapiens OX=9606 GN=PRPSAP2 PE=1 SV=1" "0.000" "False" "18.284" "13" "5" "9" "4" "369" "40.9" "7.44" "23.30" "5" "other metabolic processes;developmental processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf13793, Pf14572" "5636" "ENSG00000141127" "PRPSAP2" "B4E1M8; B4E329; B7ZKZ1; E7EMY2; hsa:5636; O60256; Q6IAS2" "" "" "0" "1" "0.924" "0.925" "0.957" "0.898" "0.964" "0.902" "0.941" "0.842" "0.460" "1128.9" "1043.0" "1044.0" "1080.9" "1014.1" "1088.4" "1018.6" "1062.2" "950.8" "519.2" "" "" "" "" "" "" "" "" "" "" "597.8" "578.3" "597.9" "497.8" "548.7" "605.4" "599.5" "579.8" "533.4" "519.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6259860464076082435" "False" "High" "IsMasterProtein" "Q9NR31" "Small COPII coat GTPase SAR1A OS=Homo sapiens OX=9606 GN=SAR1A PE=1 SV=1" "0.000" "False" "18.205" "20" "4" "7" "4" "198" "22.4" "6.68" "20.12" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf00025" "56681" "ENSG00000079332" "SAR1A" "B4DQ19; hsa:56681; Q9NR31" "Sterol regulatory element-binding proteins (SREBP) signaling" "" "1" "0" "0.957" "0.860" "0.861" "0.937" "0.896" "0.917" "0.813" "0.916" "0.999" "698.0" "668.0" "600.2" "601.3" "653.9" "625.6" "640.4" "567.6" "639.7" "697.5" "" "" "" "" "" "" "" "" "" "" "369.6" "370.4" "343.7" "276.9" "353.8" "348.0" "376.9" "309.8" "358.9" "697.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7235259727744776076" "False" "High" "IsMasterProtein" "Q7Z4W1" "L-xylulose reductase OS=Homo sapiens OX=9606 GN=DCXR PE=1 SV=2" "0.000" "False" "18.203" "16" "4" "6" "4" "244" "25.9" "8.10" "20.97" "4" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf13561" "51181" "ENSG00000169738" "DCXR" "hsa:51181; Q7Z4W1; Q9BTZ3; Q9UHY9" "" "Formation of xylulose-5-phosphate; Essential pentosuria" "2" "0" "1.114" "1.289" "1.196" "1.238" "1.164" "1.229" "1.189" "1.180" "0.662" "170.8" "190.2" "220.1" "204.3" "211.5" "198.7" "210.0" "203.0" "201.5" "113.0" "" "" "" "" "" "" "" "" "" "" "90.4" "105.5" "126.1" "94.1" "114.4" "110.6" "123.6" "110.8" "113.0" "113.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2771631356277906494" "False" "High" "IsMasterProtein" "Q01650" "Large neutral amino acids transporter small subunit 1 OS=Homo sapiens OX=9606 GN=SLC7A5 PE=1 SV=2" "0.000" "False" "18.181" "6" "2" "3" "2" "507" "55.0" "7.72" "10.88" "2" "stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf13520" "8140" "ENSG00000103257" "SLC7A5" "hsa:8140; Q01650; Q8IV97; Q9UBN8; Q9UP15; Q9UQC0" "Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; mRNA, protein, and metabolite inducation pathway by cyclosporin A; Pleural mesothelioma" "Tryptophan catabolism; Basigin interactions; Amino acid transport across the plasma membrane" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7689745804882425318" "False" "High" "IsMasterProtein" "Q6XQN6" "Nicotinate phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=NAPRT PE=1 SV=2" "0.000" "False" "18.145" "9" "5" "5" "5" "538" "57.5" "5.68" "14.82" "5" "other metabolic processes;stress response" "non-structural extracellular;cytosol;other cytoplasmic organelle" "other molecular function" "Pf17767, Pf17956" "93100" "ENSG00000147813; ENSG00000278488" "NAPRT" "A7BFI3; hsa:93100; Q6PJL1; Q6XQN4; Q6XQN5; Q6XQN6; Q8N5E8; Q9BRG0" "NAD+ biosynthetic pathways" "Neutrophil degranulation; Nicotinamide salvaging" "3" "0" "1.006" "1.058" "0.976" "1.029" "1.132" "1.010" "1.031" "1.044" "0.642" "477.2" "479.9" "504.7" "465.8" "491.2" "540.4" "481.9" "492.0" "498.2" "306.2" "" "" "" "" "" "" "" "" "" "" "252.7" "266.0" "289.1" "214.5" "265.7" "300.6" "283.6" "268.5" "279.5" "306.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-34001002036977343" "False" "High" "IsMasterProtein" "O76003" "Glutaredoxin-3 OS=Homo sapiens OX=9606 GN=GLRX3 PE=1 SV=2" "0.000" "False" "18.111" "13" "4" "6" "4" "335" "37.4" "5.39" "17.18" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00085, Pf00462" "10539" "ENSG00000108010" "GLRX3" "B3KMP7; B3KMQ5; D3DRG2; hsa:10539; O76003; Q5JV01; Q96CE0; Q9P1B0; Q9P1B1" "" "Iron uptake and transport" "1" "0" "0.972" "0.953" "1.170" "1.178" "1.233" "1.129" "0.552" "1.363" "5.592" "49.6" "48.2" "47.3" "58.0" "58.4" "61.1" "56.0" "27.4" "67.6" "277.2" "" "" "" "" "" "" "" "" "" "" "26.2" "26.7" "27.1" "26.7" "31.6" "34.0" "32.9" "14.9" "37.9" "277.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1948435004993003441" "False" "High" "IsMasterProtein" "P52594" "Arf-GAP domain and FG repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=AGFG1 PE=1 SV=2" "0.000" "False" "18.088" "8" "4" "5" "4" "562" "58.2" "8.63" "16.94" "4" "cell organization and biogenesis;other metabolic processes;transport" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01412" "3267" "ENSG00000173744" "AGFG1" "B3KUL1; E9PHX7; hsa:3267; P52594; Q15277; Q4VAS0; Q4VAS1; Q4VAS3; Q53QT8; Q53R11" "" "Cargo recognition for clathrin-mediated endocytosis" "2" "0" "1.014" "1.079" "1.014" "1.082" "1.159" "1.169" "1.122" "1.216" "0.896" "139.9" "141.8" "151.0" "141.8" "151.3" "162.1" "163.5" "156.9" "170.1" "125.4" "" "" "" "" "" "" "" "" "" "" "74.1" "78.6" "86.5" "65.3" "81.9" "90.2" "96.2" "85.7" "95.4" "125.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6835034816184829460" "False" "High" "IsMasterProtein" "Q13363" "C-terminal-binding protein 1 OS=Homo sapiens OX=9606 GN=CTBP1 PE=1 SV=2" "0.000" "False" "18.070" "13" "7" "8" "3" "440" "47.5" "6.77" "20.73" "7" "protein metabolism;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00389, Pf02826" "1487" "ENSG00000159692" "CTBP1" "Q13363; Q4W5N3; Q7Z2Q5" "Notch signaling; Ectoderm differentiation; Ectoderm differentiation; Wnt signaling pathway; Pathways affected in adenoid cystic carcinoma; Wnt signaling pathway and pluripotency; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma" "SUMOylation of transcription cofactors; Deactivation of the beta-catenin transactivating complex; Repression of WNT target genes; Signaling by TCF7L2 mutants" "14" "3" "1.013" "1.030" "0.986" "1.017" "0.988" "0.932" "0.906" "0.894" "0.701" "1291.4" "1307.7" "1330.2" "1273.1" "1312.7" "1276.0" "1203.4" "1170.4" "1154.4" "905.3" "" "" "" "" "" "" "" "" "" "" "683.8" "725.0" "761.8" "586.3" "710.2" "709.8" "708.2" "638.9" "647.6" "905.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8252267867784187079" "False" "High" "IsMasterProtein" "Q86YP4" "Transcriptional repressor p66-alpha OS=Homo sapiens OX=9606 GN=GATAD2A PE=1 SV=1" "0.000" "False" "18.039" "11" "6" "6" "6" "633" "68.0" "9.94" "14.37" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00320, Pf16563" "54815" "ENSG00000167491" "GATAD2A" "B5MC40; hsa:54815; Q7L3J2; Q86YP4; Q96F28; Q9NPU2; Q9NXS1" "" "Regulation of PTEN gene transcription; Potential therapeutics for SARS; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "6" "0" "1.000" "1.028" "1.254" "1.184" "1.016" "1.127" "1.143" "1.130" "2.055" "217.1" "217.1" "223.2" "272.3" "257.0" "220.6" "244.7" "248.2" "245.2" "446.1" "" "" "" "" "" "" "" "" "" "" "115.0" "120.4" "127.8" "125.4" "139.1" "122.7" "144.0" "135.5" "137.6" "446.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7302016058410828571" "False" "High" "IsMasterProtein" "O75940" "Survival of motor neuron-related-splicing factor 30 OS=Homo sapiens OX=9606 GN=SMNDC1 PE=1 SV=1" "0.000" "False" "18.029" "9" "2" "4" "2" "238" "26.7" "7.24" "13.21" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf06003" "10285" "ENSG00000119953" "SMNDC1" "B2RA27; D3DRB1; hsa:10285; O75940; Q5T3K6" "" "mRNA Splicing - Major Pathway" "1" "0" "1.044" "1.052" "1.080" "1.044" "0.926" "1.022" "1.158" "1.046" "0.503" "338.3" "353.1" "355.8" "365.3" "353.4" "313.3" "345.8" "391.8" "354.0" "170.2" "" "" "" "" "" "" "" "" "" "" "179.2" "195.8" "203.8" "168.2" "191.2" "174.2" "203.5" "213.8" "198.6" "170.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4307491490075501206" "False" "High" "IsMasterProtein" "P32322" "Pyrroline-5-carboxylate reductase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PYCR1 PE=1 SV=2" "0.000" "False" "18.027" "15" "4" "5" "4" "319" "33.3" "7.61" "13.14" "4" "other metabolic processes;stress response;other biological processes" "mitochondrion" "other molecular function" "Pf03807, Pf14748" "5831" "ENSG00000183010" "PYCR1" "A6NFM2; B4DMU0; hsa:5831; P32322; Q6FHI4; Q96DI6; Q9HBQ4" "Amino acid metabolism; Metabolic reprogramming in colon cancer" "Glutamate and glutamine metabolism" "3" "0" "1.134" "0.991" "1.093" "1.090" "0.981" "1.081" "1.135" "0.901" "0.558" "276.4" "313.5" "274.1" "302.1" "301.3" "271.2" "298.9" "313.7" "249.0" "154.1" "" "" "" "" "" "" "" "" "" "" "146.4" "173.8" "157.0" "139.1" "163.0" "150.9" "175.9" "171.3" "139.7" "154.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2874885037648560876" "False" "High" "IsMasterProtein" "O60869" "Endothelial differentiation-related factor 1 OS=Homo sapiens OX=9606 GN=EDF1 PE=1 SV=1" "0.000" "False" "18.013" "31" "6" "10" "6" "148" "16.4" "9.95" "29.93" "6" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01381, Pf08523" "8721" "ENSG00000107223" "EDF1" "hsa:8721; O60869; Q5T5T2; Q9UIM1" "" "" "0" "0" "0.878" "0.981" "0.879" "0.854" "0.814" "0.886" "0.875" "0.857" "0.425" "959.3" "841.8" "941.5" "843.3" "819.1" "781.3" "849.7" "839.3" "822.3" "407.9" "" "" "" "" "" "" "" "" "" "" "508.0" "466.7" "539.2" "388.3" "443.2" "434.6" "500.1" "458.1" "461.3" "407.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6282846472165231546" "False" "High" "IsMasterProtein" "Q9P289" "Serine/threonine-protein kinase 26 OS=Homo sapiens OX=9606 GN=STK26 PE=1 SV=2" "0.000" "False" "18.007" "9" "3" "4" "1" "416" "46.5" "5.29" "9.56" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf20929" "51765" "ENSG00000134602" "STK26" "B2RAU2; hsa:51765; Q3ZB77; Q8NC04; Q9BXC3; Q9BXC4; Q9P289" "" "Apoptotic cleavage of cellular proteins" "1" "0" "1.133" "0.988" "1.188" "1.148" "1.156" "1.094" "1.185" "1.111" "1.563" "121.6" "137.8" "120.1" "144.4" "139.6" "140.6" "133.0" "144.1" "135.2" "190.1" "" "" "" "" "" "" "" "" "" "" "64.4" "76.4" "68.8" "66.5" "75.6" "78.2" "78.3" "78.7" "75.8" "190.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9020069583805455300" "False" "High" "IsMasterProtein" "O60234" "Glia maturation factor gamma OS=Homo sapiens OX=9606 GN=GMFG PE=1 SV=1" "0.000" "False" "18.005" "32" "5" "7" "4" "142" "16.8" "5.26" "18.98" "5" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00241" "9535" "ENSG00000130755; ENSG00000291873" "GMFG" "hsa:9535; O60234; Q6IB37" "" "Neutrophil degranulation" "1" "1" "1.107" "1.104" "1.302" "1.285" "1.290" "1.382" "1.362" "1.555" "0.950" "338.0" "374.3" "373.1" "440.0" "434.4" "435.8" "467.2" "460.3" "525.5" "320.9" "" "" "" "" "" "" "" "" "" "" "179.0" "207.5" "213.7" "202.6" "235.0" "242.4" "274.9" "251.3" "294.8" "320.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-296072814185556824" "False" "High" "IsMasterProtein" "Q9BUI4" "DNA-directed RNA polymerase III subunit RPC3 OS=Homo sapiens OX=9606 GN=POLR3C PE=1 SV=1" "0.000" "False" "18.002" "10" "6" "6" "6" "534" "60.6" "7.31" "15.46" "6" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05645, Pf08221, Pf20912" "10623" "ENSG00000186141" "POLR3C" "hsa:10623; O15317; Q9BUI4; Q9Y3R6" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; TAR syndrome" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "10" "0" "1.143" "1.157" "1.185" "1.193" "1.056" "1.169" "1.059" "1.058" "1.644" "243.0" "277.7" "281.1" "288.1" "290.0" "256.6" "284.1" "257.3" "257.1" "399.5" "" "" "" "" "" "" "" "" "" "" "128.7" "154.0" "161.0" "132.7" "156.9" "142.7" "167.2" "140.5" "144.2" "399.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7819708601940239359" "False" "High" "IsMasterProtein" "P51946" "Cyclin-H OS=Homo sapiens OX=9606 GN=CCNH PE=1 SV=1" "0.000" "False" "17.992" "12" "4" "4" "4" "323" "37.6" "7.15" "13.86" "4" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "enzyme regulator activity" "Pf00134, Pf16899" "902" "ENSG00000134480" "CCNH" "hsa:902; P51946; Q53X72; Q8TBL9" "Cell cycle; Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "39" "0" "1.105" "0.881" "0.989" "1.063" "1.027" "1.060" "0.962" "1.059" "0.927" "658.6" "728.0" "580.5" "651.5" "699.9" "676.6" "698.2" "633.7" "697.4" "610.5" "" "" "" "" "" "" "" "" "" "" "348.7" "403.6" "332.4" "300.0" "378.7" "376.3" "410.9" "345.9" "391.2" "610.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4128551820349889228" "False" "High" "IsMasterProtein" "P51531" "Probable global transcription activator SNF2L2 OS=Homo sapiens OX=9606 GN=SMARCA2 PE=1 SV=2" "0.000" "False" "17.991" "3" "5" "6" "1" "1590" "181.2" "7.20" "13.39" "5" "cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00439, Pf07529, Pf07533, Pf08880, Pf14619" "6595" "ENSG00000080503" "SMARCA2" "B1ALG3; B1ALG4; D3DRH4; D3DRH5; hsa:6595; P51531" "Retinoblastoma gene in cancer; Pathways affected in adenoid cystic carcinoma; VEGFA-VEGFR2 signaling; Rett syndrome; Thermogenesis; Kleefstra syndrome" "RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "8" "0" "1.030" "0.925" "1.163" "1.036" "0.995" "1.323" "1.385" "1.472" "1.530" "223.4" "230.0" "206.5" "259.7" "231.5" "222.2" "295.4" "309.3" "328.7" "341.8" "" "" "" "" "" "" "" "" "" "" "118.3" "127.5" "118.3" "119.6" "125.2" "123.6" "173.9" "168.9" "184.4" "341.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2957461368778197343" "False" "High" "IsMasterProtein" "Q96I51" "RCC1-like G exchanging factor-like protein OS=Homo sapiens OX=9606 GN=RCC1L PE=1 SV=3" "0.000" "False" "17.978" "12" "4" "4" "4" "464" "49.9" "8.29" "11.18" "4" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00415, Pf13540" "81554" "ENSG00000274523" "RCC1L" "D3DXK0; F5GX55; F5H6C7; hsa:81554; Q548B1; Q8IW88; Q8N572; Q96I51; Q9H0G7" "" "" "0" "0" "1.257" "1.342" "1.776" "1.134" "1.246" "0.987" "1.366" "1.123" "0.950" "222.6" "279.8" "298.7" "395.2" "252.5" "277.4" "219.7" "303.9" "250.0" "211.5" "" "" "" "" "" "" "" "" "" "" "117.8" "155.1" "171.1" "182.0" "136.6" "154.3" "129.3" "165.9" "140.3" "211.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4078763853778873139" "False" "High" "IsMasterProtein" "O95816" "BAG family molecular chaperone regulator 2 OS=Homo sapiens OX=9606 GN=BAG2 PE=1 SV=1" "0.000" "False" "17.975" "23" "6" "8" "6" "211" "23.8" "6.70" "22.65" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "" "9532" "ENSG00000112208" "BAG2" "B4DXE2; hsa:9532; O95816; Q08AS9; Q6FID0" "Pleural mesothelioma" "Regulation of HSF1-mediated heat shock response" "2" "0" "1.134" "1.115" "1.350" "1.230" "1.286" "1.377" "1.448" "1.420" "1.896" "416.9" "472.7" "464.7" "562.7" "512.7" "536.1" "573.9" "603.7" "591.8" "790.6" "" "" "" "" "" "" "" "" "" "" "220.7" "262.1" "266.1" "259.1" "277.4" "298.2" "337.8" "329.6" "332.0" "790.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4632135778776149030" "False" "High" "IsMasterProtein" "P18085" "ADP-ribosylation factor 4 OS=Homo sapiens OX=9606 GN=ARF4 PE=1 SV=3" "0.000" "False" "17.973" "20" "3" "4" "2" "180" "20.5" "7.14" "8.62" "3" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00025" "378" "ENSG00000168374" "ARF4" "B2R7J7; hsa:378; P18085; P21371" "VEGFA-VEGFR2 signaling" "COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; VxPx cargo-targeting to cilium" "4" "0" "0.967" "0.956" "1.039" "1.069" "1.021" "1.049" "0.945" "0.971" "0.886" "231.2" "223.5" "221.0" "240.3" "247.0" "236.0" "242.6" "218.5" "224.4" "204.7" "" "" "" "" "" "" "" "" "" "" "122.4" "123.9" "126.6" "110.7" "133.7" "131.3" "142.8" "119.3" "125.9" "204.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8889177674351520658" "False" "High" "IsMasterProtein" "Q8ND24" "RING finger protein 214 OS=Homo sapiens OX=9606 GN=RNF214 PE=1 SV=2" "0.000" "False" "17.961" "8" "6" "8" "5" "703" "77.6" "6.95" "17.73" "6" "" "" "other molecular function" "" "257160" "ENSG00000167257" "RNF214" "B2RUW0; B4DTD1; hsa:257160; Q8ND24" "" "" "0" "0" "1.120" "1.003" "1.184" "1.136" "1.064" "1.223" "1.222" "1.208" "2.353" "257.1" "287.9" "257.9" "304.4" "292.0" "273.5" "314.4" "314.1" "310.5" "604.9" "" "" "" "" "" "" "" "" "" "" "136.1" "159.6" "147.7" "140.2" "158.0" "152.1" "185.0" "171.4" "174.2" "604.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "916743004623214960" "False" "High" "IsMasterProtein" "P62266" "Small ribosomal subunit protein uS12 OS=Homo sapiens OX=9606 GN=RPS23 PE=1 SV=3" "0.000" "False" "17.925" "21" "3" "4" "3" "143" "15.8" "10.49" "13.80" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00164" "6228" "ENSG00000186468" "RPS23" "hsa:6228; P39028; P62266; Q6IB08" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Formation of the ternary complex, and subsequently, the 43S complex; Response of EIF2AK4 (GCN2) to amino acid deficiency; Protein hydroxylation; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "20" "0" "1.029" "1.258" "1.040" "1.048" "1.130" "1.673" "0.966" "1.357" "1.332" "43.7" "45.0" "55.0" "45.5" "45.8" "49.5" "73.2" "42.3" "59.4" "58.3" "" "" "" "" "" "" "" "" "" "" "23.2" "24.9" "31.5" "21.0" "24.8" "27.5" "43.1" "23.1" "33.3" "58.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1393255483118757770" "False" "High" "IsMasterProtein" "Q9H2U2" "Inorganic pyrophosphatase 2, mitochondrial OS=Homo sapiens OX=9606 GN=PPA2 PE=1 SV=2" "0.000" "False" "17.909" "12" "5" "13" "4" "334" "37.9" "7.39" "30.88" "5" "other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00719" "27068" "ENSG00000138777" "PPA2" "B4DLP7; F8WDN9; hsa:27068; I6L9B6; Q4W5E9; Q6PG51; Q8TBW0; Q96E55; Q9H0T0; Q9H2U2; Q9NX37; Q9P033; Q9ULX0" "" "Mitochondrial tRNA aminoacylation; Pyrophosphate hydrolysis" "2" "0" "0.987" "1.024" "0.966" "0.976" "1.044" "0.999" "0.994" "0.952" "0.544" "1245.2" "1229.6" "1275.5" "1203.2" "1215.2" "1299.9" "1243.4" "1238.0" "1185.4" "677.2" "" "" "" "" "" "" "" "" "" "" "659.3" "681.7" "730.5" "554.1" "657.5" "723.1" "731.8" "675.8" "665.0" "677.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3530209516211162637" "False" "High" "IsMasterProtein" "Q5JRA6" "Transport and Golgi organization protein 1 homolog OS=Homo sapiens OX=9606 GN=MIA3 PE=1 SV=1" "0.000" "False" "17.907" "3" "5" "5" "5" "1907" "213.6" "4.84" "12.08" "5" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf07653" "375056" "ENSG00000154305" "MIA3" "A8K2S0; A8MT05; A8MT13; B7Z430; hsa:375056; Q14083; Q3S4X3; Q5JRA5; Q5JRA6; Q5JRB0; Q5JRB1; Q5JRB2; Q6UVY8; Q86Y60; Q8N8M5; Q92580" "Type I collagen synthesis in the context of osteogenesis imperfecta" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo concentration in the ER" "4" "0" "1.062" "1.059" "1.108" "1.166" "1.144" "1.513" "1.518" "1.464" "0.977" "750.8" "797.2" "795.4" "832.3" "875.7" "858.9" "1136.3" "1139.9" "1099.3" "733.4" "" "" "" "" "" "" "" "" "" "" "397.6" "442.0" "455.5" "383.3" "473.8" "477.7" "668.8" "622.2" "616.7" "733.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6910881260683280979" "False" "High" "IsMasterProtein" "Q9UEE9" "Craniofacial development protein 1 OS=Homo sapiens OX=9606 GN=CFDP1 PE=1 SV=1" "0.000" "False" "17.904" "16" "5" "8" "5" "299" "33.6" "4.81" "20.59" "5" "cell adhesion;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf07572" "10428" "ENSG00000153774" "CFDP1" "hsa:10428; O00393; O00404; Q9UEE9; Q9UEF0; Q9UEF1; Q9UEF8" "" "" "0" "0" "0.937" "1.018" "0.997" "0.946" "0.916" "0.945" "0.914" "0.893" "0.555" "929.6" "871.4" "945.8" "926.7" "879.6" "851.2" "878.8" "849.6" "829.8" "516.3" "" "" "" "" "" "" "" "" "" "" "492.2" "483.1" "541.7" "426.8" "475.9" "473.5" "517.2" "463.8" "465.5" "516.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "609844474726423505" "False" "High" "IsMasterProtein" "P63279" "SUMO-conjugating enzyme UBC9 OS=Homo sapiens OX=9606 GN=UBE2I PE=1 SV=1" "0.000" "False" "17.893" "20" "3" "5" "3" "158" "18.0" "8.66" "12.72" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7329" "ENSG00000103275" "UBE2I" "D3DU69; P50550; P63279; Q15698; Q59GX1; Q86VB3" "Androgen receptor signaling pathway; TGF-beta signaling pathway; TAR syndrome" "Formation of Incision Complex in GG-NER; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Meiotic synapsis; PKR-mediated signaling; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; Processing of DNA double-strand break ends; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; Postmitotic nuclear pore complex (NPC) reformation; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; SUMOylation of nuclear envelope proteins; Maturation of nucleoprotein; SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "27" "0" "0.934" "1.082" "0.973" "1.010" "1.093" "1.010" "1.104" "1.128" "0.941" "284.0" "265.2" "307.4" "276.4" "286.9" "310.2" "286.8" "313.6" "320.3" "267.1" "" "" "" "" "" "" "" "" "" "" "150.4" "147.0" "176.0" "127.3" "155.2" "172.6" "168.8" "171.2" "179.7" "267.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7512060777885112035" "False" "High" "IsMasterProtein" "P63244" "Small ribosomal subunit protein RACK1 OS=Homo sapiens OX=9606 GN=RACK1 PE=1 SV=3" "0.000" "False" "17.859" "14" "5" "10" "5" "317" "35.1" "7.69" "25.98" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;cytosol;mitochondrion;translational apparatus;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;translation activity;other molecular function" "Pf00400" "10399" "ENSG00000204628" "RACK1" "B3KTJ0; D3DWS0; hsa:10399; P25388; P63244; P99049; Q53HU2; Q5J8M6; Q5VLR4; Q6FH47" "Androgen receptor signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; VEGFA-VEGFR2 signaling; Measles virus infection; Angiotensin II receptor type 1 pathway; TROP2 regulatory signaling; Interferon type I signaling pathways" "Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-mediated ceramide production" "10" "0" "1.112" "1.105" "1.185" "1.356" "1.295" "1.471" "1.388" "1.384" "1.169" "922.9" "1026.3" "1020.2" "1094.1" "1251.8" "1195.6" "1357.2" "1280.9" "1277.4" "1078.5" "" "" "" "" "" "" "" "" "" "" "488.7" "569.0" "584.3" "503.8" "677.3" "665.1" "798.8" "699.2" "716.6" "1078.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5394846730023349610" "False" "High" "IsMasterProtein" "P55081" "Microfibrillar-associated protein 1 OS=Homo sapiens OX=9606 GN=MFAP1 PE=1 SV=2" "0.000" "False" "17.848" "15" "6" "6" "6" "439" "51.9" "4.98" "15.83" "6" "RNA metabolism OR transcription;other metabolic processes" "extracellular matrix;cytoskeleton;nucleus" "" "Pf06991" "4236" "ENSG00000140259" "MFAP1" "hsa:4236; P55081; Q86TG6" "Canonical and non-canonical Notch signaling; Ciliary landscape" "mRNA Splicing - Major Pathway" "3" "0" "0.943" "1.031" "0.980" "0.907" "0.882" "0.858" "0.900" "0.892" "0.354" "1355.8" "1279.0" "1397.2" "1328.7" "1229.8" "1195.5" "1162.6" "1219.6" "1210.0" "480.0" "" "" "" "" "" "" "" "" "" "" "717.9" "709.1" "800.2" "611.9" "665.4" "665.0" "684.2" "665.7" "678.8" "480.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5062141414675458558" "False" "High" "IsMasterProtein" "Q9P0L0" "Vesicle-associated membrane protein-associated protein A OS=Homo sapiens OX=9606 GN=VAPA PE=1 SV=3" "0.000" "False" "17.825" "14" "3" "6" "2" "249" "27.9" "8.62" "17.33" "3" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00635" "9218" "ENSG00000101558" "VAPA" "A6NDZ0; D3DUI3; hsa:9218; O75453; Q5U0E7; Q9P0L0; Q9UBZ2" "Exercise-induced circadian regulation; Cholesterol metabolism" "Neutrophil degranulation; Sphingolipid de novo biosynthesis; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "5" "1" "0.910" "0.898" "1.095" "0.940" "0.944" "1.148" "1.297" "1.291" "0.618" "132.4" "120.4" "118.9" "145.0" "124.4" "124.9" "152.0" "171.6" "170.8" "81.8" "" "" "" "" "" "" "" "" "" "" "70.1" "66.8" "68.1" "66.8" "67.3" "69.5" "89.5" "93.7" "95.8" "81.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9037349892504840241" "False" "High" "IsMasterProtein" "O00764" "Pyridoxal kinase OS=Homo sapiens OX=9606 GN=PDXK PE=1 SV=1" "0.000" "False" "17.824" "15" "5" "11" "5" "312" "35.1" "6.13" "24.36" "5" "other metabolic processes" "non-structural extracellular;nucleus;other cell component" "kinase activity;other molecular function" "Pf08543" "8566" "ENSG00000160209" "PDXK" "O00764; Q7Z2Y0; Q9BS02" "" "Neutrophil degranulation; Vitamin B6 activation to pyridoxal phosphate" "2" "0" "0.974" "0.975" "1.015" "0.985" "0.993" "1.124" "0.995" "0.866" "0.634" "598.6" "583.2" "583.9" "607.8" "589.5" "594.6" "672.6" "595.8" "518.6" "379.5" "" "" "" "" "" "" "" "" "" "" "317.0" "323.3" "334.4" "279.9" "319.0" "330.8" "395.9" "325.2" "290.9" "379.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7171410217774938332" "False" "High" "IsMasterProtein" "Q96T51" "RUN and FYVE domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RUFY1 PE=1 SV=2" "0.000" "False" "17.763" "9" "7" "7" "7" "708" "79.8" "5.74" "19.17" "7" "transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363, Pf02759" "80230" "ENSG00000176783; ENSG00000284260" "RUFY1" "hsa:80230; Q59FF3; Q71S93; Q96T51; Q9H6I3" "" "Synthesis of PIPs at the plasma membrane" "1" "0" "0.988" "1.034" "1.105" "1.080" "1.035" "1.332" "1.222" "1.314" "2.481" "735.3" "726.2" "760.5" "812.6" "794.3" "761.0" "979.3" "898.8" "966.3" "1824.5" "" "" "" "" "" "" "" "" "" "" "389.3" "402.6" "435.6" "374.2" "429.8" "423.3" "576.3" "490.6" "542.1" "1824.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8993945663539599820" "False" "High" "IsMasterProtein" "P61026" "Ras-related protein Rab-10 OS=Homo sapiens OX=9606 GN=RAB10 PE=1 SV=1" "0.000" "False" "17.747" "23" "6" "11" "4" "200" "22.5" "8.38" "26.06" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "10890" "ENSG00000084733" "RAB10" "D6W538; hsa:10890; O88386; P61026; Q6IA52; Q9D7X6; Q9H0T3" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; Neutrophil degranulation; RAB geranylgeranylation" "5" "0" "0.989" "0.974" "0.982" "1.046" "1.035" "1.010" "1.030" "0.972" "0.656" "509.1" "503.4" "496.1" "499.9" "532.4" "526.8" "514.3" "524.5" "495.0" "333.9" "" "" "" "" "" "" "" "" "" "" "269.6" "279.1" "284.1" "230.2" "288.1" "293.0" "302.7" "286.3" "277.7" "333.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3246938043361698856" "False" "High" "IsMasterProtein" "O94842" "TOX high mobility group box family member 4 OS=Homo sapiens OX=9606 GN=TOX4 PE=1 SV=1" "0.000" "False" "17.674" "6" "4" "5" "4" "621" "66.2" "5.06" "14.44" "4" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00505" "9878" "ENSG00000092203" "TOX4" "B4DPY8; B4DSM0; E7EV69; hsa:9878; O94842" "" "" "0" "0" "1.007" "1.054" "1.063" "1.069" "1.034" "1.079" "1.146" "1.144" "1.063" "744.5" "749.5" "785.0" "791.3" "795.8" "770.1" "803.6" "853.2" "851.5" "791.7" "" "" "" "" "" "" "" "" "" "" "394.2" "415.5" "449.6" "364.4" "430.5" "428.4" "472.9" "465.7" "477.6" "791.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2494116660910275017" "False" "High" "IsMasterProtein" "Q9H814" "Phosphorylated adapter RNA export protein OS=Homo sapiens OX=9606 GN=PHAX PE=1 SV=1" "0.000" "False" "17.670" "13" "5" "6" "5" "394" "44.4" "5.40" "17.18" "5" "transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10258" "51808" "ENSG00000164902" "PHAX" "hsa:51808; Q9H814; Q9H8W1" "" "RNA polymerase II transcribes snRNA genes; snRNP Assembly" "2" "0" "0.963" "0.965" "1.099" "0.970" "0.958" "1.119" "1.101" "1.083" "1.150" "420.5" "405.0" "405.6" "461.9" "407.9" "402.9" "470.6" "462.8" "455.3" "483.4" "" "" "" "" "" "" "" "" "" "" "222.6" "224.6" "232.3" "212.7" "220.7" "224.1" "276.9" "252.6" "255.4" "483.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3741204735065001472" "False" "High" "IsMasterProtein" "Q8WXF1" "Paraspeckle component 1 OS=Homo sapiens OX=9606 GN=PSPC1 PE=1 SV=1" "0.000" "False" "17.665" "11" "6" "8" "5" "523" "58.7" "6.67" "20.17" "6" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf08075" "55269" "ENSG00000121390" "PSPC1" "hsa:55269; Q5JTQ3; Q8NCZ9; Q8WXE8; Q8WXF1; Q9NV36" "" "" "0" "0" "1.083" "1.120" "1.122" "1.123" "1.196" "1.112" "1.157" "1.241" "2.544" "200.3" "217.0" "224.3" "224.7" "224.9" "239.6" "222.7" "231.7" "248.5" "509.4" "" "" "" "" "" "" "" "" "" "" "106.0" "120.3" "128.4" "103.5" "121.7" "133.3" "131.0" "126.5" "139.4" "509.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8670958433918101160" "False" "High" "IsMasterProtein" "P26373" "Large ribosomal subunit protein eL13 OS=Homo sapiens OX=9606 GN=RPL13 PE=1 SV=4" "0.000" "False" "17.651" "17" "4" "4" "4" "211" "24.2" "11.65" "14.47" "4" "protein metabolism;other metabolic processes;developmental processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01294" "6137" "ENSG00000167526" "RPL13" "B4DLX3; F5H1S2; hsa:6137; P26373; Q3KQT8; Q567Q8; Q9BPX0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.066" "1.065" "1.351" "1.068" "1.171" "1.115" "1.114" "1.136" "0.683" "683.1" "728.3" "727.2" "923.0" "729.3" "800.2" "761.8" "760.8" "776.0" "466.3" "" "" "" "" "" "" "" "" "" "" "361.7" "403.8" "416.5" "425.1" "394.6" "445.1" "448.3" "415.3" "435.3" "466.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3607998631011874723" "False" "High" "IsMasterProtein" "Q9UBQ7" "Glyoxylate reductase/hydroxypyruvate reductase OS=Homo sapiens OX=9606 GN=GRHPR PE=1 SV=1" "0.000" "False" "17.641" "8" "3" "8" "3" "328" "35.6" "7.39" "28.17" "3" "other metabolic processes" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00389, Pf02826" "9380" "ENSG00000137106" "GRHPR" "hsa:9380; Q5T945; Q9H3E9; Q9H636; Q9UBQ7; Q9UKX1" "" "Glyoxylate metabolism and glycine degradation" "1" "0" "1.002" "1.002" "1.028" "0.946" "1.130" "0.939" "0.959" "0.928" "0.684" "419.0" "419.7" "420.0" "430.8" "396.3" "473.4" "393.5" "401.7" "389.0" "286.6" "" "" "" "" "" "" "" "" "" "" "221.9" "232.7" "240.5" "198.4" "214.4" "263.3" "231.6" "219.3" "218.2" "286.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8650406954565681421" "False" "High" "IsMasterProtein" "P48426" "Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha OS=Homo sapiens OX=9606 GN=PIP4K2A PE=1 SV=2" "0.000" "False" "17.638" "11" "4" "5" "3" "406" "46.2" "6.99" "11.05" "4" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf01504" "5305" "ENSG00000150867" "PIP4K2A" "B0YJ66; B4DGX2; D3DRV1; hsa:5305; P48426; P53807; Q5VUX3" "Regulation of actin cytoskeleton; G13 signaling pathway" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus" "6" "0" "1.027" "1.134" "1.024" "1.035" "0.931" "0.960" "0.798" "0.963" "0.963" "102.1" "104.9" "115.8" "104.6" "105.7" "95.1" "98.0" "81.5" "98.4" "98.4" "" "" "" "" "" "" "" "" "" "" "54.1" "58.1" "66.3" "48.1" "57.2" "52.9" "57.7" "44.5" "55.2" "98.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8732346175470674622" "False" "High" "IsMasterProtein" "Q86UP2" "Kinectin OS=Homo sapiens OX=9606 GN=KTN1 PE=1 SV=1" "0.000" "False" "17.542" "5" "8" "11" "7" "1357" "156.2" "5.64" "25.86" "8" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi" "cytoskeletal activity" "Pf05104" "3895" "ENSG00000126777" "KTN1" "B4DZ88; hsa:3895; Q13999; Q14707; Q15387; Q17RZ5; Q5GGW3; Q86UP2; Q86W57" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RND2 GTPase cycle; RHOG GTPase cycle; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; RND3 GTPase cycle; RHO GTPases activate KTN1" "11" "0" "0.876" "0.916" "0.918" "1.025" "0.951" "1.160" "1.196" "1.447" "1.339" "260.3" "227.9" "238.5" "238.9" "266.6" "247.4" "301.9" "311.4" "376.7" "348.6" "" "" "" "" "" "" "" "" "" "" "137.8" "126.3" "136.6" "110.0" "144.3" "137.6" "177.7" "170.0" "211.3" "348.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2739049111137792080" "False" "High" "IsMasterProtein" "P13861" "cAMP-dependent protein kinase type II-alpha regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR2A PE=1 SV=2" "0.000" "False" "17.534" "14" "4" "4" "4" "404" "45.5" "5.07" "11.36" "4" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf02197" "5576" "ENSG00000114302" "PRKAR2A" "hsa:5576; P13861; Q16823; Q9BUB1" "Myometrial relaxation and contraction pathways; G protein signaling pathways; TGF-beta signaling pathway; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; GDNF signaling; Calcium regulation in cardiac cells; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "Factors involved in megakaryocyte development and platelet production; FCGR3A-mediated IL10 synthesis; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Hedgehog 'off' state; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase; ROBO receptors bind AKAP5" "22" "0" "1.021" "1.068" "1.199" "0.907" "1.079" "1.093" "0.877" "0.830" "1.164" "34.9" "35.6" "37.3" "41.9" "31.7" "37.7" "38.2" "30.6" "29.0" "40.6" "" "" "" "" "" "" "" "" "" "" "18.5" "19.8" "21.4" "19.3" "17.1" "21.0" "22.5" "16.7" "16.3" "40.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7515792609303095651" "False" "High" "IsMasterProtein" "P61204" "ADP-ribosylation factor 3 OS=Homo sapiens OX=9606 GN=ARF3 PE=1 SV=2" "0.000" "False" "17.534" "24" "4" "11" "2" "181" "20.6" "7.43" "22.40" "4" "transport" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00025" "377" "ENSG00000134287" "ARF3" "A8K6G8; B7ZB63; hsa:377; P16587; P61204" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Synthesis of PIPs at the Golgi membrane" "3" "0" "0.955" "0.954" "0.971" "1.088" "0.998" "1.155" "1.043" "0.991" "0.578" "677.8" "647.1" "646.5" "658.0" "737.3" "676.4" "783.0" "707.0" "671.6" "392.1" "" "" "" "" "" "" "" "" "" "" "358.9" "358.8" "370.2" "303.0" "398.9" "376.2" "460.8" "385.9" "376.7" "392.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "306109377846906281" "False" "High" "IsMasterProtein" "P49247" "Ribose-5-phosphate isomerase OS=Homo sapiens OX=9606 GN=RPIA PE=1 SV=3" "0.000" "False" "17.513" "21" "5" "8" "5" "311" "33.2" "8.54" "18.59" "5" "other metabolic processes" "cytosol" "other molecular function" "Pf06026" "22934" "ENSG00000153574" "RPIA" "hsa:22934; P49247; Q541P9; Q96BJ6" "Pentose phosphate metabolism; Metabolic reprogramming in colon cancer; Pentose phosphate pathway in senescent cells" "Pentose phosphate pathway; RPIA deficiency: failed conversion of R5P to RU5P; RPIA deficiency: failed conversion of RU5P to R5P" "6" "0" "1.019" "0.916" "0.948" "0.977" "0.936" "1.062" "0.956" "0.959" "0.602" "426.5" "434.7" "390.5" "404.4" "416.6" "399.2" "453.1" "407.6" "409.2" "256.8" "" "" "" "" "" "" "" "" "" "" "225.8" "241.0" "223.7" "186.3" "225.4" "222.0" "266.7" "222.5" "229.5" "256.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6735907081845110604" "False" "High" "IsMasterProtein" "Q9Y2L1" "Exosome complex exonuclease RRP44 OS=Homo sapiens OX=9606 GN=DIS3 PE=1 SV=2" "0.000" "False" "17.489" "6" "5" "7" "5" "958" "108.9" "7.14" "20.13" "5" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00773, Pf13638, Pf17215, Pf17216, Pf17849" "22894" "ENSG00000083520" "DIS3" "A6NI21; B2RBL2; hsa:22894; Q5W0P7; Q5W0P8; Q658Z7; Q7Z481; Q8WWI2; Q9UG36; Q9Y2L1" "" "ATF4 activates genes in response to endoplasmic reticulum stress; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Major pathway of rRNA processing in the nucleolus and cytosol; KSRP (KHSRP) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3251544276452061183" "False" "High" "IsMasterProtein" "P26368" "Splicing factor U2AF 65 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF2 PE=1 SV=4" "0.000" "False" "17.474" "10" "5" "6" "5" "475" "53.5" "9.09" "14.62" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "11338" "ENSG00000063244" "U2AF2" "hsa:11338; P26368; Q96HC5" "mRNA processing; Warburg effect modulated by deubiquitinating enzymes and their substrates" "Protein hydroxylation; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway" "7" "0" "1.014" "1.041" "0.984" "1.045" "1.111" "1.268" "1.253" "1.322" "0.901" "834.4" "846.0" "868.3" "820.7" "872.0" "927.3" "1058.4" "1045.9" "1103.4" "752.2" "" "" "" "" "" "" "" "" "" "" "441.8" "469.0" "497.3" "378.0" "471.8" "515.8" "622.9" "570.9" "619.0" "752.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6575601821171362980" "False" "High" "IsMasterProtein" "P39019" "Small ribosomal subunit protein eS19 OS=Homo sapiens OX=9606 GN=RPS19 PE=1 SV=2" "0.000" "False" "17.466" "25" "4" "5" "4" "145" "16.1" "10.32" "14.18" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01090" "6223" "ENSG00000105372" "RPS19" "hsa:6223; P39019" "Complement system; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "20" "0" "0.998" "1.005" "1.212" "1.104" "1.072" "1.362" "1.429" "1.930" "0.886" "1043.9" "1041.5" "1048.7" "1265.0" "1152.3" "1119.3" "1421.8" "1491.9" "2015.1" "924.9" "" "" "" "" "" "" "" "" "" "" "552.8" "577.4" "600.6" "582.6" "623.5" "622.6" "836.8" "814.4" "1130.4" "924.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-507762156530799771" "False" "High" "IsMasterProtein" "O43670" "BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=1" "0.000" "False" "17.462" "7" "3" "11" "3" "478" "50.7" "9.10" "28.82" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "" "7756" "ENSG00000010244" "ZNF207" "A8K6Y6; E1P660; E1P661; E1P662; hsa:7756; O43670; Q53XS9; Q96HW5; Q9BUQ7" "" "" "0" "0" "1.018" "0.978" "1.144" "1.025" "1.115" "1.077" "1.098" "1.071" "0.570" "489.4" "498.1" "478.6" "559.8" "501.5" "545.9" "526.9" "537.3" "524.0" "279.0" "" "" "" "" "" "" "" "" "" "" "259.2" "276.2" "274.1" "257.8" "271.3" "303.7" "310.1" "293.3" "294.0" "279.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6701833234650983688" "False" "High" "IsMasterProtein" "O43865" "S-adenosylhomocysteine hydrolase-like protein 1 OS=Homo sapiens OX=9606 GN=AHCYL1 PE=1 SV=2" "0.000" "False" "17.457" "8" "4" "11" "2" "530" "58.9" "6.89" "34.62" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00670, Pf05221" "10768" "ENSG00000168710" "AHCYL1" "B4E168; hsa:10768; O43865; Q2TAJ6; Q502W8; Q5VSM0; Q6P171; Q96PK4; Q9UG84" "Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways" "Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; Regulation of insulin secretion; VEGFR2 mediated cell proliferation; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation" "12" "0" "0.964" "1.011" "1.074" "1.007" "0.965" "0.922" "0.862" "0.870" "0.786" "349.2" "336.6" "353.1" "375.1" "351.6" "336.8" "322.1" "301.1" "303.6" "274.6" "" "" "" "" "" "" "" "" "" "" "184.9" "186.6" "202.2" "172.8" "190.2" "187.4" "189.5" "164.4" "170.3" "274.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9008482199911470815" "False" "High" "IsMasterProtein" "O43516" "WAS/WASL-interacting protein family member 1 OS=Homo sapiens OX=9606 GN=WIPF1 PE=1 SV=3" "0.000" "False" "17.441" "8" "3" "6" "3" "503" "51.2" "11.47" "21.31" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf02205" "7456" "ENSG00000115935" "WIPF1" "B8ZZM1; D3DPE4; hsa:7456; O43516; Q15220; Q53TA9; Q6MZU9; Q9BU37; Q9UNP1" "" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs" "5" "0" "1.028" "1.083" "1.121" "1.089" "0.978" "1.045" "1.082" "1.086" "0.616" "599.0" "616.1" "648.7" "671.7" "652.6" "586.1" "626.1" "648.0" "650.6" "369.1" "" "" "" "" "" "" "" "" "" "" "317.2" "341.6" "371.5" "309.3" "353.1" "326.0" "368.5" "353.7" "365.0" "369.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-780269141344007222" "False" "High" "IsMasterProtein" "P15814" "Immunoglobulin lambda-like polypeptide 1 OS=Homo sapiens OX=9606 GN=IGLL1 PE=1 SV=1" "0.000" "False" "17.431" "17" "3" "4" "3" "213" "22.9" "10.07" "12.88" "3" "other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf07654" "3543" "ENSG00000128322" "IGLL1" "hsa:3543; P15814; Q0P681" "Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway" "Cell surface interactions at the vascular wall" "3" "0" "1.018" "1.016" "0.981" "0.924" "0.941" "0.944" "0.769" "0.917" "2.690" "669.6" "681.8" "680.1" "657.2" "618.4" "630.2" "631.9" "514.7" "614.2" "1801.0" "" "" "" "" "" "" "" "" "" "" "354.6" "378.0" "389.5" "302.7" "334.6" "350.6" "371.9" "280.9" "344.5" "1801.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7392710609967527407" "False" "High" "IsMasterProtein" "Q96BH1" "E3 ubiquitin-protein ligase RNF25 OS=Homo sapiens OX=9606 GN=RNF25 PE=1 SV=1" "0.000" "False" "17.426" "13" "5" "6" "5" "459" "51.2" "6.54" "14.81" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus" "other molecular function" "Pf05773, Pf13639" "64320" "ENSG00000163481" "RNF25" "A8K0D6; hsa:64320; Q53HQ5; Q96BH1; Q9H874" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.032" "1.061" "1.064" "1.005" "0.994" "0.988" "1.016" "1.084" "0.816" "384.6" "396.9" "408.0" "409.3" "386.4" "382.2" "380.1" "390.8" "416.9" "313.7" "" "" "" "" "" "" "" "" "" "" "203.6" "220.0" "233.7" "188.5" "209.1" "212.6" "223.7" "213.3" "233.9" "313.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1310996743308863221" "False" "High" "IsMasterProtein" "Q9Y3A5" "Ribosome maturation protein SBDS OS=Homo sapiens OX=9606 GN=SBDS PE=1 SV=4" "0.000" "False" "17.422" "17" "5" "7" "5" "250" "28.7" "8.75" "16.47" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;translation activity;nucleic acid binding activity" "Pf01172, Pf09377, Pf20268" "51119" "ENSG00000126524" "SBDS" "A8K0P4; Q96FX0; Q9NV53; Q9Y3A5" "Genetic causes of porto-sinusoidal vascular disease" "" "1" "0" "1.003" "1.035" "1.141" "1.214" "1.169" "1.124" "1.048" "1.114" "1.759" "205.5" "206.1" "212.7" "234.5" "249.4" "240.3" "230.9" "215.4" "229.0" "361.4" "" "" "" "" "" "" "" "" "" "" "108.8" "114.3" "121.8" "108.0" "135.0" "133.7" "135.9" "117.6" "128.5" "361.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3208052669097016746" "False" "High" "IsMasterProtein" "P51608" "Methyl-CpG-binding protein 2 OS=Homo sapiens OX=9606 GN=MECP2 PE=1 SV=1" "0.000" "False" "17.414" "9" "4" "5" "4" "486" "52.4" "9.95" "14.03" "4" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01429" "4204" "ENSG00000169057" "MECP2" "hsa:4204; O15233; P51608; Q6QHH9; Q7Z384" "Ectoderm differentiation; MECP2 and associated Rett syndrome; Lung fibrosis; Rett syndrome; Transcription co-factors SKI and SKIL protein partners; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Neurogenesis regulation in the olfactory epithelium; ADHD and autism (ASD) linked metabolic pathways and SNP; Sudden infant death syndrome (SIDS) susceptibility pathways" "" "10" "0" "1.017" "1.022" "1.003" "1.014" "0.939" "0.905" "1.009" "0.996" "0.692" "340.8" "346.5" "348.1" "341.9" "345.6" "319.9" "308.4" "343.7" "339.5" "235.7" "" "" "" "" "" "" "" "" "" "" "180.4" "192.1" "199.4" "157.5" "187.0" "178.0" "181.5" "187.6" "190.4" "235.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4267228453861492918" "False" "High" "IsMasterProtein" "Q8IVM0" "Coiled-coil domain-containing protein 50 OS=Homo sapiens OX=9606 GN=CCDC50 PE=1 SV=1" "0.000" "False" "17.414" "14" "4" "5" "4" "306" "35.8" "6.65" "14.95" "4" "other biological processes" "cytosol;other cell component" "other molecular function" "Pf15295" "152137" "ENSG00000152492" "CCDC50" "hsa:152137; Q86VH7; Q8IVM0" "" "" "0" "0" "1.000" "0.997" "1.068" "1.031" "0.986" "1.062" "1.042" "0.947" "0.448" "505.8" "505.8" "504.0" "540.4" "521.4" "498.5" "536.9" "527.1" "479.0" "226.6" "" "" "" "" "" "" "" "" "" "" "267.8" "280.4" "288.7" "248.9" "282.1" "277.3" "316.0" "287.7" "268.7" "226.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5100210059596347713" "False" "High" "IsMasterProtein" "P04899" "Guanine nucleotide-binding protein G(i) subunit alpha-2 OS=Homo sapiens OX=9606 GN=GNAI2 PE=1 SV=3" "0.000" "False" "17.406" "10" "3" "5" "2" "355" "40.4" "5.54" "14.87" "3" "cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00503" "2771" "ENSG00000114353" "GNAI2" "B3KTZ0; B4DYA0; B4E2X5; hsa:2771; P04899; Q6B6N3; Q8IZ71" "Thyroid stimulating hormone (TSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; S1P receptor signal transduction; Complement system; G protein signaling pathways; Chemokine signaling pathway; Hippo signaling regulation pathways; Purinergic signaling; Opioid receptor pathways; Calcium regulation in cardiac cells; 5q35 copy number variation; Serotonin HTR1 group and FOS pathway" "G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Adrenaline,noradrenaline inhibits insulin secretion" "22" "0" "1.017" "0.968" "0.974" "1.032" "1.145" "1.150" "1.053" "1.149" "1.314" "216.6" "220.2" "209.7" "210.9" "223.6" "248.0" "249.1" "228.1" "249.0" "284.7" "" "" "" "" "" "" "" "" "" "" "114.7" "122.1" "120.1" "97.1" "121.0" "137.9" "146.6" "124.5" "139.7" "284.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2491921153129945541" "False" "High" "IsMasterProtein" "Q9UHV9" "Prefoldin subunit 2 OS=Homo sapiens OX=9606 GN=PFDN2 PE=1 SV=1" "0.000" "False" "17.401" "32" "5" "5" "5" "154" "16.6" "6.58" "13.24" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01920" "5202" "ENSG00000143256" "PFDN2" "hsa:5202; Q9P0P7; Q9UHV9; Q9UN05" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "0.958" "1.102" "1.262" "0.863" "0.937" "1.015" "0.943" "0.948" "0.709" "565.5" "541.5" "622.9" "713.5" "487.9" "529.9" "574.0" "533.4" "536.2" "401.2" "" "" "" "" "" "" "" "" "" "" "299.4" "300.2" "356.7" "328.6" "264.0" "294.7" "337.8" "291.2" "300.8" "401.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7131720843867798084" "False" "High" "IsMasterProtein" "Q9BT09" "Protein canopy homolog 3 OS=Homo sapiens OX=9606 GN=CNPY3 PE=1 SV=1" "0.000" "False" "17.383" "18" "5" "6" "5" "278" "30.7" "5.49" "20.15" "5" "stress response" "ER/Golgi" "signal transduction activity or receptor binding" "Pf11938" "10695" "ENSG00000137161" "CNPY3" "hsa:10695; O15412; Q0P6I2; Q8NF54; Q8WTU8; Q9BT09; Q9P0F2" "" "Trafficking and processing of endosomal TLR" "1" "0" "0.984" "1.102" "0.969" "0.982" "0.921" "0.974" "1.061" "1.070" "0.663" "753.6" "741.5" "830.5" "730.3" "740.2" "694.2" "734.0" "799.6" "805.9" "499.3" "" "" "" "" "" "" "" "" "" "" "399.0" "411.1" "475.6" "336.3" "400.5" "386.2" "432.0" "436.5" "452.1" "499.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8677465183251509063" "False" "High" "IsMasterProtein" "Q9NX55" "Huntingtin-interacting protein K OS=Homo sapiens OX=9606 GN=HYPK PE=1 SV=3" "0.000" "False" "17.357" "41" "5" "9" "5" "121" "13.6" "4.82" "18.84" "5" "protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf19026" "25764" "ENSG00000242028" "HYPK" "C9JKJ0; hsa:25764; O75408; Q8WUW8; Q9NX55; Q9P024" "" "" "0" "0" "0.980" "1.029" "0.924" "1.029" "0.875" "0.872" "1.040" "0.971" "0.429" "766.4" "750.7" "788.3" "708.0" "788.9" "670.4" "668.3" "797.4" "744.6" "328.6" "" "" "" "" "" "" "" "" "" "" "405.8" "416.2" "451.4" "326.1" "426.8" "372.9" "393.3" "435.3" "417.7" "328.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4457645785715096452" "False" "High" "IsMasterProtein" "Q9BS26" "Endoplasmic reticulum resident protein 44 OS=Homo sapiens OX=9606 GN=ERP44 PE=1 SV=1" "0.000" "False" "17.346" "13" "5" "6" "4" "406" "46.9" "5.26" "14.47" "5" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00085, Pf13848" "23071" "ENSG00000023318" "ERP44" "hsa:23071; O60319; Q4VXC1; Q5VWZ7; Q6UW14; Q8WX67; Q9BS26" "" "Neutrophil degranulation" "1" "0" "0.809" "0.702" "1.014" "0.880" "0.878" "0.999" "0.861" "0.960" "0.911" "67.6" "54.7" "47.4" "68.6" "59.5" "59.4" "67.6" "58.2" "64.9" "61.6" "" "" "" "" "" "" "" "" "" "" "35.8" "30.3" "27.2" "31.6" "32.2" "33.0" "39.8" "31.8" "36.4" "61.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4143955501491186019" "False" "High" "IsMasterProtein" "P55084" "Trifunctional enzyme subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=HADHB PE=1 SV=3" "0.000" "False" "17.342" "9" "5" "6" "4" "474" "51.3" "9.41" "16.06" "5" "other metabolic processes;other biological processes" "other membranes;mitochondrion;ER/Golgi" "nucleic acid binding activity;other molecular function" "Pf00108, Pf02803" "3032" "ENSG00000138029" "HADHB" "B2RB16; B4E2W0; hsa:3032; O14969; P55084; Q53TA6; Q96C77; Q9H3F5; Q9T2V8" "Fatty acid beta-oxidation; Valproic acid pathway; Female steroid hormones in cardiomyocyte energy metabolism; Sudden infant death syndrome (SIDS) susceptibility pathways" "Acyl chain remodeling of CL; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA" "12" "0" "0.966" "0.995" "1.192" "0.953" "0.980" "1.033" "0.642" "0.964" "5.188" "322.3" "311.2" "320.6" "384.2" "307.1" "315.9" "333.0" "207.0" "310.8" "1672.2" "" "" "" "" "" "" "" "" "" "" "170.7" "172.6" "183.6" "176.9" "166.1" "175.7" "196.0" "113.0" "174.3" "1672.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7801299591553380074" "False" "High" "IsMasterProtein" "P52298" "Nuclear cap-binding protein subunit 2 OS=Homo sapiens OX=9606 GN=NCBP2 PE=1 SV=1" "0.000" "False" "17.333" "22" "4" "6" "4" "156" "18.0" "8.21" "15.96" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "22916" "ENSG00000114503" "NCBP2" "B2RE91; B4DMK7; E9PAR5; hsa:22916; P52298; Q14924; Q2TS50" "mRNA processing; 3q29 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; snRNP Assembly; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Polymerase II Pre-transcription Events; mRNA Capping; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM; Processing of Intronless Pre-mRNAs; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "29" "0" "1.058" "0.991" "1.008" "0.935" "0.989" "0.878" "1.061" "0.924" "0.703" "1259.6" "1332.4" "1248.4" "1270.0" "1177.5" "1245.9" "1105.5" "1336.8" "1164.4" "885.8" "" "" "" "" "" "" "" "" "" "" "666.9" "738.7" "714.9" "584.9" "637.1" "693.0" "650.6" "729.7" "653.2" "885.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1852571755298916304" "False" "High" "IsMasterProtein" "Q9UKX7" "Nuclear pore complex protein Nup50 OS=Homo sapiens OX=9606 GN=NUP50 PE=1 SV=2" "0.000" "False" "17.289" "13" "6" "9" "6" "468" "50.1" "7.06" "14.95" "6" "transport" "other membranes;nucleus" "" "Pf00638, Pf08911" "10762" "ENSG00000093000" "NUP50" "B1AHA4; B2RB15; hsa:10762; O75644; Q8N6V5; Q9NPM9; Q9NPR6; Q9P1K5; Q9UKX7" "" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Regulation of HSF1-mediated heat shock response; ISG15 antiviral mechanism; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus" "28" "0" "0.919" "0.964" "0.894" "0.937" "0.899" "0.921" "0.965" "0.969" "0.633" "488.0" "448.3" "470.5" "436.2" "457.3" "438.9" "449.4" "470.8" "472.7" "308.8" "" "" "" "" "" "" "" "" "" "" "258.4" "248.5" "269.5" "200.9" "247.4" "244.2" "264.5" "257.0" "265.2" "308.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6708028902102911891" "False" "High" "IsMasterProtein" "P21281" "V-type proton ATPase subunit B, brain isoform OS=Homo sapiens OX=9606 GN=ATP6V1B2 PE=1 SV=3" "0.000" "False" "17.258" "9" "5" "8" "5" "511" "56.5" "5.81" "20.72" "5" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00006, Pf02874" "526" "ENSG00000147416" "ATP6V1B2" "B2R5Z3; D3DSQ5; hsa:526; P21281; Q14544; Q15859; Q96IR0" "" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "5" "0" "0.951" "0.938" "0.997" "1.010" "0.930" "0.967" "1.034" "0.978" "0.801" "991.6" "943.1" "930.6" "988.7" "1002.0" "922.4" "958.9" "1025.6" "969.9" "793.9" "" "" "" "" "" "" "" "" "" "" "525.1" "522.9" "532.9" "455.3" "542.1" "513.1" "564.3" "559.8" "544.1" "793.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3200179838073860903" "False" "High" "IsMasterProtein" "O76031" "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial OS=Homo sapiens OX=9606 GN=CLPX PE=1 SV=2" "0.000" "False" "17.241" "8" "5" "5" "5" "633" "69.2" "7.58" "13.44" "5" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf07724, Pf10431" "10845" "ENSG00000166855" "CLPX" "A1L428; A8K8F1; B9EGI8; hsa:10845; O76031; Q9H4D9" "" "Mitochondrial protein degradation" "1" "0" "1.052" "1.006" "1.022" "1.129" "1.062" "0.999" "1.005" "0.993" "0.887" "509.6" "536.0" "512.6" "520.6" "575.3" "541.2" "509.1" "512.2" "506.0" "451.9" "" "" "" "" "" "" "" "" "" "" "269.8" "297.2" "293.6" "239.8" "311.3" "301.0" "299.6" "279.6" "283.8" "451.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5155444033397587021" "False" "High" "IsMasterProtein" "Q06265" "Exosome complex component RRP45 OS=Homo sapiens OX=9606 GN=EXOSC9 PE=1 SV=3" "0.000" "False" "17.236" "10" "5" "5" "5" "439" "48.9" "5.29" "15.22" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "5393" "ENSG00000123737" "EXOSC9" "hsa:5393; Q06265; Q12883; Q4W5P5; Q86Y41; Q86Y48" "Ciliary landscape" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "7" "0" "1.072" "0.970" "1.046" "1.067" "1.025" "1.095" "1.127" "0.988" "0.519" "531.2" "569.5" "515.2" "555.9" "566.6" "544.4" "581.7" "598.7" "525.0" "275.5" "" "" "" "" "" "" "" "" "" "" "281.3" "315.7" "295.1" "256.0" "306.6" "302.8" "342.3" "326.8" "294.5" "275.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7082716862048425116" "False" "High" "IsMasterProtein" "Q9BPX3" "Condensin complex subunit 3 OS=Homo sapiens OX=9606 GN=NCAPG PE=1 SV=1" "0.000" "False" "17.204" "4" "4" "4" "4" "1015" "114.3" "5.59" "12.65" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "" "Pf12719" "64151" "ENSG00000109805" "NCAPG" "hsa:64151; Q3MJE0; Q96SV9; Q9BPX3; Q9BUR3; Q9BVY1; Q9H914; Q9H9Z6; Q9HBI9" "" "Condensation of Prometaphase Chromosomes" "1" "0" "1.000" "0.898" "1.045" "0.900" "1.024" "0.951" "0.241" "0.862" "9.381" "234.1" "234.1" "210.1" "244.5" "210.6" "239.8" "222.5" "56.4" "201.7" "2196.0" "" "" "" "" "" "" "" "" "" "" "123.9" "129.8" "120.3" "112.6" "113.9" "133.4" "131.0" "30.8" "113.1" "2196.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7964397888877464485" "False" "High" "IsMasterProtein" "P50897" "Palmitoyl-protein thioesterase 1 OS=Homo sapiens OX=9606 GN=PPT1 PE=1 SV=1" "0.000" "False" "17.203" "14" "3" "4" "3" "306" "34.2" "6.52" "12.91" "3" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02089" "5538" "ENSG00000131238" "PPT1" "B4DY24; hsa:5538; P50897; Q6FGQ4" "" "Fatty acyl-CoA biosynthesis" "1" "0" "1.091" "1.241" "1.312" "1.274" "1.076" "1.233" "1.213" "1.101" "0.812" "105.0" "114.5" "130.3" "137.7" "133.7" "112.9" "129.4" "127.4" "115.6" "85.2" "" "" "" "" "" "" "" "" "" "" "55.6" "63.5" "74.6" "63.4" "72.3" "62.8" "76.2" "69.5" "64.8" "85.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8148433569690540229" "False" "High" "IsMasterProtein" "Q96C36" "Pyrroline-5-carboxylate reductase 2 OS=Homo sapiens OX=9606 GN=PYCR2 PE=1 SV=1" "0.000" "False" "17.197" "18" "5" "10" "5" "320" "33.6" "7.77" "15.76" "5" "other metabolic processes;stress response" "mitochondrion" "other molecular function" "Pf03807, Pf14748" "29920" "ENSG00000143811" "PYCR2" "A8K798; hsa:29920; Q7Z515; Q96C36; Q9Y5J4" "Metabolic reprogramming in colon cancer" "Glutamate and glutamine metabolism" "2" "0" "1.044" "1.064" "1.081" "1.030" "1.078" "1.000" "1.005" "1.019" "0.734" "569.9" "594.9" "606.5" "616.0" "586.9" "614.5" "570.1" "572.9" "581.0" "418.1" "" "" "" "" "" "" "" "" "" "" "301.8" "329.8" "347.3" "283.7" "317.5" "341.8" "335.5" "312.7" "326.0" "418.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5527327330749920032" "False" "High" "IsMasterProtein" "P61019" "Ras-related protein Rab-2A OS=Homo sapiens OX=9606 GN=RAB2A PE=1 SV=1" "0.000" "False" "17.165" "16" "3" "4" "3" "212" "23.5" "6.54" "14.90" "3" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00071" "5862" "ENSG00000104388" "RAB2A" "B2R5W8; B4DMQ5; hsa:5862; P08886; P61019" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape" "RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization" "4" "0" "0.967" "0.995" "1.005" "0.969" "1.037" "0.998" "1.061" "0.973" "0.516" "389.3" "376.5" "387.2" "391.3" "377.4" "403.8" "388.5" "413.1" "378.8" "200.9" "" "" "" "" "" "" "" "" "" "" "206.1" "208.8" "221.8" "180.2" "204.2" "224.6" "228.6" "225.5" "212.5" "200.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6953685933096655099" "False" "High" "IsMasterProtein" "Q8N465" "D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=D2HGDH PE=1 SV=3" "0.000" "False" "17.165" "9" "6" "8" "6" "521" "56.4" "7.99" "23.58" "6" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf01565, Pf02913" "728294" "ENSG00000180902" "D2HGDH" "B4E3L6; E7ENP2; hsa:728294; Q6IQ24; Q8N465; Q8N5Q8" "2q37 copy number variation syndrome" "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate" "2" "0" "1.016" "0.992" "0.959" "1.109" "1.031" "1.067" "1.027" "1.013" "0.709" "668.5" "679.3" "663.3" "641.1" "741.5" "689.5" "713.6" "686.7" "676.8" "474.1" "" "" "" "" "" "" "" "" "" "" "354.0" "376.6" "379.9" "295.2" "401.2" "383.5" "420.0" "374.8" "379.7" "474.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7482655995969634953" "False" "High" "IsMasterProtein" "Q9Y237" "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 OS=Homo sapiens OX=9606 GN=PIN4 PE=1 SV=1" "0.000" "False" "17.146" "26" "3" "6" "3" "131" "13.8" "9.77" "17.34" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13616" "5303" "ENSG00000102309" "PIN4" "A8E0G6; B3KXM0; F5H1P5; hsa:5303; Q0D2H3; Q3MHV0; Q52M21; Q5HYW6; Q6IRW4; Q9Y237" "" "" "0" "0" "0.974" "0.990" "0.907" "0.835" "0.828" "0.802" "0.871" "0.759" "0.505" "739.1" "720.2" "732.0" "670.2" "617.0" "611.8" "592.7" "644.1" "561.0" "373.5" "" "" "" "" "" "" "" "" "" "" "391.4" "399.3" "419.2" "308.7" "333.8" "340.3" "348.8" "351.6" "314.7" "373.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1468795769571451317" "False" "High" "IsMasterProtein" "Cont_P06868" "Plasminogen OS=Bos taurus OX=9913 GN=PLG PE=1 SV=2" "0.000" "True" "17.121" "7" "6" "6" "6" "812" "91.2" "7.50" "13.73" "6" "protein metabolism;stress response;other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding;other molecular function" "Pf00024, Pf00051, Pf00089" "280897" "" "PLG" "bta:280897; P06868; Q28162" "" "" "0" "0" "1.040" "0.930" "0.933" "1.095" "1.082" "0.899" "1.036" "1.026" "0.728" "687.0" "714.6" "638.6" "640.9" "752.1" "743.0" "617.9" "711.7" "705.0" "500.0" "" "" "" "" "" "" "" "" "" "" "363.7" "396.2" "365.7" "295.2" "406.9" "413.3" "363.6" "388.5" "395.5" "500.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "124053754926249858" "False" "High" "IsMasterProtein" "Q9UBF2" "Coatomer subunit gamma-2 OS=Homo sapiens OX=9606 GN=COPG2 PE=1 SV=1" "0.000" "False" "17.104" "5" "5" "5" "5" "871" "97.6" "5.81" "15.02" "5" "transport" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01602, Pf08752, Pf16381" "26958" "ENSG00000158623" "COPG2" "A6NH74; hsa:26958; Q2NLA0; Q54AC3; Q8WVW8; Q9UBF2" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "2" "0" "1.020" "0.980" "0.932" "1.025" "1.053" "1.058" "0.981" "1.005" "1.079" "870.3" "887.9" "852.6" "811.2" "892.4" "916.6" "920.6" "854.2" "874.9" "938.9" "" "" "" "" "" "" "" "" "" "" "460.8" "492.3" "488.3" "373.6" "482.8" "509.9" "541.8" "466.3" "490.8" "938.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5777002652342293914" "False" "High" "IsMasterProtein" "Q9H307" "Pinin OS=Homo sapiens OX=9606 GN=PNN PE=1 SV=5" "0.000" "False" "17.078" "9" "7" "7" "7" "717" "81.6" "7.14" "13.38" "7" "cell adhesion;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04696, Pf04697" "5411" "ENSG00000100941" "PNN" "B4DZX8; hsa:5411; O60899; Q53EM7; Q6P5X4; Q7KYL1; Q99738; Q9H307; Q9UHZ9; Q9UQR9" "" "mRNA Splicing - Major Pathway" "1" "0" "1.169" "1.077" "1.114" "1.113" "1.061" "1.215" "1.219" "1.272" "0.835" "506.1" "591.6" "545.3" "563.8" "563.5" "537.0" "615.0" "617.1" "643.6" "422.4" "" "" "" "" "" "" "" "" "" "" "268.0" "328.0" "312.3" "259.7" "304.9" "298.7" "362.0" "336.8" "361.1" "422.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "647250025127974157" "False" "High" "IsMasterProtein" "Q15004" "PCNA-associated factor OS=Homo sapiens OX=9606 GN=PCLAF PE=1 SV=1" "0.000" "False" "17.078" "41" "4" "8" "4" "111" "12.0" "9.83" "23.61" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15715" "9768" "ENSG00000166803" "PCLAF" "A6NNU5; A8K3Y3; G9G694; G9G696; hsa:9768; Q15004" "" "Termination of translesion DNA synthesis" "1" "0" "1.002" "1.127" "0.976" "0.903" "0.877" "0.863" "0.924" "0.806" "0.390" "628.7" "629.9" "708.8" "613.6" "567.9" "551.2" "542.9" "580.8" "506.8" "245.3" "" "" "" "" "" "" "" "" "" "" "332.9" "349.2" "405.9" "282.6" "307.3" "306.6" "319.5" "317.1" "284.3" "245.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1107540500627023376" "False" "High" "IsMasterProtein" "Q96EE3" "Nucleoporin SEH1 OS=Homo sapiens OX=9606 GN=SEH1L PE=1 SV=3" "0.000" "False" "17.057" "12" "5" "5" "5" "360" "39.6" "8.09" "14.30" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "81929" "ENSG00000085415" "SEH1L" "A8K5B1; hsa:81929; Q8NFU6; Q96EE3; Q96MH3; Q9C069" "" "Amino acids regulate mTORC1" "1" "0" "1.016" "0.955" "0.983" "0.995" "1.012" "1.086" "1.024" "1.057" "0.943" "639.6" "650.0" "610.5" "628.9" "636.3" "647.3" "694.6" "654.8" "676.2" "603.3" "" "" "" "" "" "" "" "" "" "" "338.6" "360.4" "349.6" "289.6" "344.3" "360.0" "408.8" "357.4" "379.3" "603.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2106198041571123129" "False" "High" "IsMasterProtein" "Q9UMS4" "Pre-mRNA-processing factor 19 OS=Homo sapiens OX=9606 GN=PRPF19 PE=1 SV=1" "0.000" "False" "17.045" "13" "7" "12" "7" "504" "55.1" "6.61" "29.55" "7" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400, Pf04564, Pf08606" "27339" "ENSG00000110107" "PRPF19" "Q9UMS4" "" "mRNA Splicing - Major Pathway; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of TC-NER Pre-Incision Complex" "5" "0" "0.927" "0.922" "0.962" "0.964" "1.178" "1.095" "1.008" "1.071" "0.483" "1300.4" "1205.3" "1199.3" "1251.5" "1253.6" "1532.3" "1423.9" "1310.9" "1392.5" "628.3" "" "" "" "" "" "" "" "" "" "" "688.6" "668.3" "686.8" "576.4" "678.2" "852.4" "838.0" "715.6" "781.1" "628.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5188184621199488866" "False" "High" "IsMasterProtein" "Q9GZT3" "SRA stem-loop-interacting RNA-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=SLIRP PE=1 SV=1" "0.000" "False" "17.014" "39" "4" "7" "4" "109" "12.3" "10.24" "21.56" "4" "other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "" "Pf00076" "81892" "ENSG00000119705" "SLIRP" "hsa:81892; J3KMY7; Q9GZT3" "" "Mitochondrial RNA degradation" "1" "0" "0.975" "1.009" "0.968" "0.977" "0.935" "0.896" "0.859" "0.905" "1.394" "572.4" "558.0" "577.7" "554.3" "559.3" "535.3" "512.7" "491.8" "518.2" "797.8" "" "" "" "" "" "" "" "" "" "" "303.1" "309.4" "330.8" "255.3" "302.6" "297.8" "301.7" "268.4" "290.7" "797.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3716051439609727834" "False" "High" "IsMasterProtein" "Q9NW82" "WD repeat-containing protein 70 OS=Homo sapiens OX=9606 GN=WDR70 PE=1 SV=1" "0.000" "False" "16.991" "10" "6" "6" "6" "654" "73.2" "6.33" "14.58" "6" "" "nucleus;other cell component" "other molecular function" "Pf00400" "55100" "ENSG00000082068" "WDR70" "hsa:55100; Q9H053; Q9NW82" "" "mRNA Splicing - Major Pathway" "1" "0" "1.127" "0.968" "1.214" "1.187" "1.151" "0.982" "1.145" "1.073" "0.833" "258.1" "291.0" "249.8" "313.4" "306.5" "297.1" "253.5" "295.5" "277.0" "214.9" "" "" "" "" "" "" "" "" "" "" "136.7" "161.3" "143.1" "144.3" "165.8" "165.2" "149.2" "161.3" "155.4" "214.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4107495286689168051" "False" "High" "IsMasterProtein" "P42566" "Epidermal growth factor receptor substrate 15 OS=Homo sapiens OX=9606 GN=EPS15 PE=1 SV=2" "0.000" "False" "16.978" "7" "7" "7" "7" "896" "98.6" "4.64" "14.65" "7" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "" "2060" "ENSG00000085832" "EPS15" "B2R8J7; D3DPJ2; hsa:2060; P42566; Q5SRH4" "VEGFA-VEGFR2 signaling; Ebola virus infection in host; EGF/EGFR signaling pathway" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "8" "0" "0.996" "0.920" "0.984" "1.034" "1.094" "1.136" "1.161" "1.342" "1.723" "527.5" "525.5" "485.5" "519.2" "545.5" "576.8" "599.3" "612.2" "707.7" "908.8" "" "" "" "" "" "" "" "" "" "" "279.3" "291.4" "278.1" "239.1" "295.1" "320.9" "352.7" "334.2" "397.0" "908.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5853825877774435955" "False" "High" "IsMasterProtein" "Q96HQ2" "CDKN2AIP N-terminal-like protein OS=Homo sapiens OX=9606 GN=CDKN2AIPNL PE=1 SV=1" "0.000" "False" "16.955" "37" "3" "3" "3" "116" "13.2" "5.00" "10.90" "3" "" "" "" "Pf11952" "91368" "ENSG00000237190" "CDKN2AIPNL" "hsa:91368; Q8WVE3; Q96HQ2" "" "" "0" "0" "1.021" "0.984" "1.018" "1.011" "1.014" "1.041" "1.029" "1.039" "0.778" "409.9" "418.7" "403.5" "417.3" "414.3" "415.8" "426.9" "421.7" "425.8" "319.0" "" "" "" "" "" "" "" "" "" "" "217.1" "232.1" "231.1" "192.2" "224.1" "231.3" "251.3" "230.2" "238.9" "319.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8766016140567224551" "False" "High" "IsMasterProtein" "Q08380" "Galectin-3-binding protein OS=Homo sapiens OX=9606 GN=LGALS3BP PE=1 SV=1" "0.000" "False" "16.930" "9" "5" "8" "5" "585" "65.3" "5.27" "20.59" "5" "cell adhesion;stress response;transport;signal transduction" "non-structural extracellular;other membranes;other cell component" "other molecular function" "Pf00530, Pf07707" "3959" "ENSG00000108679" "LGALS3BP" "hsa:3959; Q08380; Q7M4S0; Q9UCH8; Q9UCH9; Q9UCI0" "Network map of SARS-CoV-2 signaling pathway; 11p11.2 copy number variation syndrome" "Platelet degranulation" "3" "0" "0.994" "0.921" "0.987" "0.932" "0.810" "0.929" "0.926" "0.828" "0.422" "286.5" "284.7" "263.7" "282.9" "266.9" "232.2" "266.3" "265.4" "237.2" "121.0" "" "" "" "" "" "" "" "" "" "" "151.7" "157.9" "151.0" "130.3" "144.4" "129.1" "156.7" "144.9" "133.0" "121.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1178646061152564690" "False" "High" "IsMasterProtein" "P40938" "Replication factor C subunit 3 OS=Homo sapiens OX=9606 GN=RFC3 PE=1 SV=2" "0.000" "False" "16.927" "12" "4" "5" "4" "356" "40.5" "8.34" "13.79" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13177" "5983" "ENSG00000133119" "RFC3" "C9JU95; hsa:5983; O15252; P40938; Q5W0E8" "Gastric cancer network 2; Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching" "28" "0" "1.323" "1.361" "1.186" "1.223" "1.224" "1.067" "1.228" "1.114" "2.007" "33.5" "44.3" "45.6" "39.8" "41.0" "41.0" "35.8" "41.2" "37.3" "67.3" "" "" "" "" "" "" "" "" "" "" "17.7" "24.6" "26.1" "18.3" "22.2" "22.8" "21.1" "22.5" "20.9" "67.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6934522081491213014" "False" "High" "IsMasterProtein" "P11908" "Ribose-phosphate pyrophosphokinase 2 OS=Homo sapiens OX=9606 GN=PRPS2 PE=1 SV=2" "0.000" "False" "16.901" "18" "6" "8" "2" "318" "34.7" "6.61" "19.05" "6" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf13793, Pf14572" "5634" "ENSG00000101911" "PRPS2" "hsa:5634; P11908; Q0VDH9; Q0VDI0; Q15245; Q2TAK7" "" "5-Phosphoribose 1-diphosphate biosynthesis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-765021547925747573" "False" "High" "IsMasterProtein" "P49366" "Deoxyhypusine synthase OS=Homo sapiens OX=9606 GN=DHPS PE=1 SV=1" "0.000" "False" "16.895" "11" "3" "3" "3" "369" "40.9" "5.36" "11.11" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf01916" "1725" "ENSG00000095059" "DHPS" "A8K688; hsa:1725; M0R1I5; P49366; Q13184; Q13276; Q9UDG0" "" "Hypusine synthesis from eIF5A-lysine" "1" "0" "0.949" "0.980" "0.906" "0.942" "0.907" "1.033" "1.009" "0.953" "0.473" "629.8" "597.4" "617.2" "570.8" "593.2" "571.4" "650.9" "635.6" "600.5" "298.1" "" "" "" "" "" "" "" "" "" "" "333.5" "331.2" "353.5" "262.9" "320.9" "317.8" "383.0" "347.0" "336.9" "298.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5055182102876441761" "False" "High" "IsMasterProtein" "Q9BRT9" "DNA replication complex GINS protein SLD5 OS=Homo sapiens OX=9606 GN=GINS4 PE=1 SV=1" "0.000" "False" "16.882" "19" "4" "7" "4" "223" "26.0" "4.98" "15.69" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes" "nucleus;other cell component" "" "Pf05916, Pf16922" "84296" "ENSG00000147536" "GINS4" "B2R8H5; D3DSY0; hsa:84296; Q8N648; Q9BRT9" "" "Unwinding of DNA" "1" "0" "1.017" "1.096" "0.953" "1.079" "1.060" "0.937" "1.028" "0.999" "1.130" "477.4" "485.4" "523.0" "454.8" "515.2" "506.2" "447.3" "490.9" "477.1" "539.6" "" "" "" "" "" "" "" "" "" "" "252.8" "269.1" "299.5" "209.4" "278.7" "281.6" "263.2" "268.0" "267.6" "539.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "175169128914004892" "False" "High" "IsMasterProtein" "Q30154" "HLA class II histocompatibility antigen, DR beta 5 chain OS=Homo sapiens OX=9606 GN=HLA-DRB5 PE=1 SV=1" "0.000" "False" "16.877" "18" "4" "5" "2" "266" "30.0" "6.93" "12.46" "4" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00969, Pf07654" "3127" "ENSG00000198502" "HLA-DRB5" "B2RBV6; C7C4X3; hsa:3127; O00157; O00283; O46700; Q29703; Q29787; Q29788; Q30126; Q30150; Q30154; Q30199; Q6SJR2; Q7M2H9; Q8HWS7; Q8WLR5; Q9MY54; Q9XRX6" "Allograft rejection; Ebola virus infection in host; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway" "Interferon gamma signaling; Downstream TCR signaling; MHC class II antigen presentation; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling" "11" "0" "1.023" "1.001" "0.952" "1.036" "1.095" "1.059" "1.125" "0.882" "0.647" "349.4" "357.5" "349.8" "332.8" "362.1" "382.5" "370.0" "393.1" "308.2" "225.9" "" "" "" "" "" "" "" "" "" "" "185.0" "198.2" "200.4" "153.3" "195.9" "212.8" "217.8" "214.6" "172.9" "225.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7969393992682693722" "False" "High" "IsMasterProtein" "Q9NUJ1" "Palmitoyl-protein thioesterase ABHD10, mitochondrial OS=Homo sapiens OX=9606 GN=ABHD10 PE=1 SV=1" "0.000" "False" "16.846" "12" "3" "4" "3" "306" "33.9" "8.57" "11.67" "3" "protein metabolism;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00561" "55347" "ENSG00000144827" "ABHD10" "B7Z6A8; C9IZX5; D3DN63; hsa:55347; Q8TCF9; Q9NUJ1" "" "Glucuronidation" "1" "0" "1.002" "0.890" "1.019" "0.965" "1.078" "1.011" "0.998" "0.974" "0.531" "524.5" "525.5" "467.0" "534.2" "506.0" "565.6" "530.3" "523.4" "510.7" "278.6" "" "" "" "" "" "" "" "" "" "" "277.7" "291.3" "267.4" "246.0" "273.8" "314.6" "312.1" "285.7" "286.5" "278.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5604354164667528726" "False" "High" "IsMasterProtein" "Q13769" "THO complex subunit 5 homolog OS=Homo sapiens OX=9606 GN=THOC5 PE=1 SV=2" "0.000" "False" "16.831" "6" "4" "6" "4" "683" "78.5" "6.87" "18.35" "4" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf09766" "8563" "ENSG00000100296" "THOC5" "hsa:8563; O60839; Q13769; Q9UPZ5" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Signaling by CSF1 (M-CSF) in myeloid cells" "4" "0" "0.987" "0.984" "1.019" "1.036" "1.074" "1.097" "1.001" "1.142" "1.800" "444.5" "438.9" "437.5" "452.8" "460.3" "477.5" "487.6" "444.8" "507.5" "800.0" "" "" "" "" "" "" "" "" "" "" "235.4" "243.3" "250.6" "208.5" "249.1" "265.6" "287.0" "242.8" "284.7" "800.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8650097818779685703" "False" "High" "IsMasterProtein" "P62857" "Small ribosomal subunit protein eS28 OS=Homo sapiens OX=9606 GN=RPS28 PE=1 SV=1" "0.000" "False" "16.824" "52" "4" "16" "4" "69" "7.8" "10.70" "24.08" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01200" "6234" "ENSG00000233927" "RPS28" "hsa:6234; P25112; P62857" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "19" "0" "1.092" "1.116" "1.286" "1.114" "0.997" "1.390" "1.314" "1.138" "0.489" "507.7" "554.3" "566.8" "653.1" "565.8" "506.2" "705.6" "667.3" "577.8" "248.3" "" "" "" "" "" "" "" "" "" "" "268.8" "307.3" "324.6" "300.8" "306.1" "281.6" "415.3" "364.3" "324.2" "248.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3710113209643881705" "False" "High" "IsMasterProtein" "O75794" "Translation initiation factor eIF2 assembly protein OS=Homo sapiens OX=9606 GN=CDC123 PE=1 SV=1" "0.000" "False" "16.817" "11" "3" "4" "3" "336" "39.1" "4.81" "9.34" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other cell component" "" "Pf07065" "8872" "ENSG00000151465" "CDC123" "A8JZZ7; hsa:8872; O75794; Q14107; Q5T0L4; Q5T0L5; Q5T0L7; Q5T0L8; Q5T0L9" "" "" "0" "0" "1.064" "1.083" "1.064" "1.204" "1.364" "1.093" "0.910" "1.107" "0.895" "108.4" "115.3" "117.4" "115.3" "130.5" "147.8" "118.4" "98.6" "120.0" "97.0" "" "" "" "" "" "" "" "" "" "" "57.4" "63.9" "67.2" "53.1" "70.6" "82.2" "69.7" "53.8" "67.3" "97.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4830366311257218609" "False" "High" "IsMasterProtein" "P48147" "Prolyl endopeptidase OS=Homo sapiens OX=9606 GN=PREP PE=1 SV=2" "0.000" "False" "16.806" "7" "6" "7" "6" "710" "80.6" "5.86" "18.26" "6" "protein metabolism" "cytosol;nucleus;other cell component" "other molecular function" "Pf00326, Pf02897" "5550" "ENSG00000085377" "PREP" "hsa:5550; P48147; Q8N6D4" "" "" "0" "0" "0.991" "0.910" "1.059" "1.020" "0.954" "1.047" "0.786" "0.965" "3.485" "449.7" "445.6" "409.0" "476.1" "458.6" "428.8" "471.0" "353.5" "433.9" "1567.2" "" "" "" "" "" "" "" "" "" "" "238.1" "247.0" "234.2" "219.3" "248.1" "238.5" "277.2" "193.0" "243.4" "1567.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6421392599925785436" "False" "High" "IsMasterProtein" "Q9HD15" "Steroid receptor RNA activator 1 OS=Homo sapiens OX=9606 GN=SRA1 PE=1 SV=2" "0.000" "False" "16.803" "15" "3" "5" "3" "224" "24.4" "7.50" "17.25" "3" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07304" "10011" "ENSG00000213523" "SRA1" "hsa:10011; Q6NVU9; Q8IXM1; Q9HD13; Q9HD14; Q9HD15" "" "" "0" "0" "1.045" "1.116" "1.072" "0.970" "0.977" "1.022" "1.131" "0.968" "0.686" "406.4" "424.6" "453.4" "435.5" "394.2" "397.2" "415.3" "459.5" "393.5" "278.8" "" "" "" "" "" "" "" "" "" "" "215.2" "235.4" "259.6" "200.6" "213.3" "220.9" "244.4" "250.8" "220.8" "278.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8303897606251246511" "False" "High" "IsMasterProtein" "Q96HW7" "Integrator complex subunit 4 OS=Homo sapiens OX=9606 GN=INTS4 PE=1 SV=2" "0.000" "False" "16.797" "7" "6" "8" "6" "963" "108.1" "6.44" "19.58" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf13646, Pf20168" "92105" "ENSG00000149262" "INTS4" "hsa:92105; Q2YD62; Q6PJG4; Q7Z4E7; Q96G32; Q96GA1; Q96HW7; Q9BRC0" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "1.000" "1.070" "1.010" "1.012" "1.048" "0.947" "1.005" "0.994" "0.674" "783.5" "783.2" "838.3" "791.5" "792.6" "821.2" "742.1" "787.4" "778.4" "527.8" "" "" "" "" "" "" "" "" "" "" "414.9" "434.2" "480.1" "364.5" "428.8" "456.8" "436.8" "429.8" "436.7" "527.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8285089334394207834" "False" "High" "IsMasterProtein" "Q12959" "Disks large homolog 1 OS=Homo sapiens OX=9606 GN=DLG1 PE=1 SV=2" "0.000" "False" "16.777" "6" "5" "5" "5" "904" "100.4" "5.76" "14.93" "5" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00018, Pf00595, Pf00625, Pf09058, Pf10600, Pf10608" "1739" "ENSG00000075711" "DLG1" "A5YKK7; B4DGU1; B4DGZ8; B7ZMM0; B9EIQ5; D3DXB8; D3DXB9; E7EWL7; E9PG21; hsa:1739; Q12958; Q12959" "Brain-derived neurotrophic factor (BDNF) signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Disruption of postsynaptic signaling by CNV; 3q29 copy number variation syndrome; Cell lineage map for neuronal differentiation" "Assembly and cell surface presentation of NMDA receptors; RAF/MAP kinase cascade; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Synaptic adhesion-like molecules; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; NrCAM interactions; Activation of Ca-permeable Kainate Receptor" "15" "0" "1.023" "1.017" "1.161" "0.975" "0.969" "1.080" "0.975" "0.934" "1.237" "205.1" "209.7" "208.6" "238.1" "199.9" "198.6" "221.4" "200.0" "191.6" "253.7" "" "" "" "" "" "" "" "" "" "" "108.6" "116.3" "119.5" "109.6" "108.1" "110.5" "130.3" "109.2" "107.5" "253.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6920554993800994285" "False" "High" "IsMasterProtein" "Q02880" "DNA topoisomerase 2-beta OS=Homo sapiens OX=9606 GN=TOP2B PE=1 SV=3" "0.000" "False" "16.762" "4" "5" "6" "3" "1626" "183.2" "8.00" "11.75" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00204, Pf00521, Pf01751, Pf02518, Pf08070, Pf16898" "7155" "ENSG00000077097" "TOP2B" "hsa:7155; Q02880; Q13600; Q9UMG8; Q9UQP8" "" "SUMOylation of DNA replication proteins" "1" "1" "1.030" "0.997" "0.943" "1.015" "0.976" "0.956" "0.886" "0.961" "1.318" "253.6" "261.2" "253.0" "239.2" "257.4" "247.7" "242.5" "224.6" "243.9" "334.4" "" "" "" "" "" "" "" "" "" "" "134.3" "144.8" "144.9" "110.2" "139.2" "137.8" "142.7" "122.6" "136.8" "334.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7212838211136634633" "False" "High" "IsMasterProtein" "Q9NYY8" "FAST kinase domain-containing protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=FASTKD2 PE=1 SV=1" "0.000" "False" "16.755" "7" "4" "5" "4" "710" "81.4" "8.05" "15.06" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "nucleic acid binding activity" "Pf06743, Pf08368, Pf08373" "22868" "ENSG00000118246" "FASTKD2" "hsa:22868; Q9NVX6; Q9NYY8; Q9Y2H7" "" "FASTK family proteins regulate processing and stability of mitochondrial RNAs" "1" "0" "1.097" "1.209" "1.217" "1.173" "1.183" "1.142" "0.994" "1.023" "1.412" "197.1" "216.1" "238.3" "239.9" "231.2" "233.2" "225.1" "195.9" "201.5" "278.3" "" "" "" "" "" "" "" "" "" "" "104.3" "119.8" "136.4" "110.5" "125.1" "129.7" "132.5" "106.9" "113.1" "278.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2438255133986472284" "False" "High" "IsMasterProtein" "Q9H8H0" "Nucleolar protein 11 OS=Homo sapiens OX=9606 GN=NOL11 PE=1 SV=1" "0.000" "False" "16.747" "6" "4" "7" "4" "719" "81.1" "6.07" "18.53" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf08168, Pf20998" "25926" "ENSG00000130935" "NOL11" "B7Z5V9; hsa:25926; Q7L5S1; Q9H8H0; Q9UG18" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.073" "1.100" "1.064" "1.061" "1.041" "1.105" "1.106" "1.157" "0.535" "757.0" "811.9" "832.8" "805.1" "802.8" "788.2" "836.4" "836.9" "875.8" "404.7" "" "" "" "" "" "" "" "" "" "" "400.8" "450.2" "476.9" "370.8" "434.4" "438.4" "492.2" "456.8" "491.3" "404.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5749593247568362596" "False" "High" "IsMasterProtein" "Q9NYV4" "Cyclin-dependent kinase 12 OS=Homo sapiens OX=9606 GN=CDK12 PE=1 SV=2" "0.000" "False" "16.718" "3" "5" "8" "4" "1490" "164.1" "9.44" "20.99" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "51755" "ENSG00000167258" "CDK12" "A7E2B2; B4DYX4; B9EIQ6; hsa:51755; O94978; Q9NYV4" "17q12 copy number variation syndrome" "TP53 Regulates Transcription of DNA Repair Genes" "2" "0" "0.987" "0.987" "1.023" "1.018" "0.921" "0.918" "1.091" "1.073" "0.674" "431.5" "425.7" "426.0" "441.3" "439.2" "397.5" "396.0" "470.6" "463.2" "290.7" "" "" "" "" "" "" "" "" "" "" "228.5" "236.0" "244.0" "203.3" "237.6" "221.1" "233.1" "256.9" "259.8" "290.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2652497111054879184" "False" "High" "IsMasterProtein" "Q96HE7" "ERO1-like protein alpha OS=Homo sapiens OX=9606 GN=ERO1A PE=1 SV=2" "0.000" "False" "16.715" "9" "4" "5" "4" "468" "54.4" "5.68" "15.49" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf04137" "30001" "ENSG00000197930" "ERO1A" "A8K9X4; A8MYW1; hsa:30001; Q7LD45; Q96HE7; Q9P1Q9; Q9UKV6" "" "Detoxification of Reactive Oxygen Species" "1" "0" "1.008" "0.912" "1.014" "0.932" "1.008" "0.940" "0.902" "0.934" "0.721" "725.5" "731.1" "661.5" "736.0" "676.0" "731.1" "681.8" "654.3" "677.5" "523.3" "" "" "" "" "" "" "" "" "" "" "384.2" "405.3" "378.8" "339.0" "365.8" "406.7" "401.2" "357.1" "380.1" "523.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6072091565905259276" "False" "High" "IsMasterProtein" "P42574" "Caspase-3 OS=Homo sapiens OX=9606 GN=CASP3 PE=1 SV=2" "0.000" "False" "16.701" "13" "3" "5" "2" "277" "31.6" "6.54" "15.13" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00656" "836" "ENSG00000164305" "CASP3" "A8K5M2; D3DP53; hsa:836; P42574; Q96AN1; Q96KP2" "miRNA regulation of DNA damage response; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; AGE/RAGE pathway; Allograft rejection; Corticotropin-releasing hormone signaling pathway; Parkinson's disease pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Copper homeostasis; Hepatitis C and hepatocellular carcinoma; MAPK signaling pathway; Apoptosis modulation by HSP70; ERK pathway in Huntington's disease; Oxidative damage response; miRNA regulation of p53 pathway in prostate cancer; Prion disease pathway; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; MTHFR deficiency; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; Peroxiredoxin 2 induced ovarian failure; Complement system in neuronal development and plasticity; Orexin receptor pathway; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Urotensin-II-mediated signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; IL-26 signaling pathways; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response" "Caspase-mediated cleavage of cytoskeletal proteins; Degradation of the extracellular matrix; Apoptosis induced DNA fragmentation; Signaling by Hippo; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Caspase activation via Dependence Receptors in the absence of ligand; Pyroptosis; NADE modulates death signalling; Other interleukin signaling; Apoptotic cleavage of cell adhesion proteins; Stimulation of the cell death response by PAK-2p34" "60" "0" "0.986" "0.913" "1.084" "1.047" "0.931" "0.898" "0.831" "0.887" "0.543" "224.3" "221.2" "204.7" "243.2" "234.7" "208.8" "201.3" "186.5" "199.0" "121.8" "" "" "" "" "" "" "" "" "" "" "118.8" "122.7" "117.2" "112.0" "127.0" "116.1" "118.5" "101.8" "111.6" "121.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6787199481091963945" "False" "High" "IsMasterProtein" "P04053" "DNA nucleotidylexotransferase OS=Homo sapiens OX=9606 GN=DNTT PE=1 SV=3" "0.000" "False" "16.697" "6" "3" "5" "3" "509" "58.5" "8.43" "14.54" "3" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00533, Pf01909, Pf10391, Pf14716, Pf14791" "1791" "ENSG00000107447" "DNTT" "hsa:1791; P04053; Q53FH1; Q5W103; Q96E50" "" "" "0" "0" "1.028" "0.933" "1.262" "1.219" "0.982" "1.354" "0.749" "1.261" "6.873" "103.4" "106.3" "96.4" "130.5" "126.0" "101.5" "139.9" "77.4" "130.3" "710.3" "" "" "" "" "" "" "" "" "" "" "54.7" "58.9" "55.2" "60.1" "68.2" "56.4" "82.3" "42.2" "73.1" "710.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2325443013124673649" "False" "High" "IsMasterProtein" "Q6NXE6" "Armadillo repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=ARMC6 PE=1 SV=2" "0.000" "False" "16.693" "7" "4" "5" "4" "501" "54.1" "6.24" "10.53" "4" "other biological processes" "cytosol" "" "Pf00514" "93436" "ENSG00000105676" "ARMC6" "B4DI98; hsa:93436; O94999; Q6NXE6; Q9BTH5" "" "" "0" "0" "0.999" "1.019" "1.247" "1.177" "1.118" "1.265" "0.778" "1.195" "6.444" "357.8" "357.6" "364.7" "446.3" "421.3" "400.2" "452.5" "278.5" "427.4" "2305.9" "" "" "" "" "" "" "" "" "" "" "189.5" "198.3" "208.8" "205.5" "227.9" "222.6" "266.3" "152.0" "239.8" "2305.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6933649257231024003" "False" "High" "IsMasterProtein" "P16930" "Fumarylacetoacetase OS=Homo sapiens OX=9606 GN=FAH PE=1 SV=2" "0.000" "False" "16.689" "7" "3" "4" "3" "419" "46.3" "6.95" "10.43" "3" "other metabolic processes" "cytosol" "other molecular function" "Pf01557, Pf09298" "2184" "ENSG00000103876" "FAH" "B2R9X1; D3DW95; hsa:2184; P16930; Q53XA7" "Amino acid metabolism" "Tyrosine catabolism" "2" "0" "1.158" "0.829" "1.028" "1.115" "0.957" "1.142" "0.879" "0.970" "0.607" "117.8" "136.5" "97.7" "121.1" "131.4" "112.8" "134.6" "103.5" "114.3" "71.6" "" "" "" "" "" "" "" "" "" "" "62.4" "75.7" "56.0" "55.8" "71.1" "62.7" "79.2" "56.5" "64.1" "71.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-10968856719763814" "False" "High" "IsMasterProtein" "P62081" "Small ribosomal subunit protein eS7 OS=Homo sapiens OX=9606 GN=RPS7 PE=1 SV=1" "0.000" "False" "16.682" "22" "5" "6" "5" "194" "22.1" "10.10" "18.82" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01251" "6201" "ENSG00000171863" "RPS7" "hsa:6201; P23821; P24818; P62081; Q57Z92; Q6IPH1" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery; rRNA modification in the nucleus and cytosol" "20" "0" "1.087" "1.089" "1.113" "1.211" "1.216" "1.421" "1.554" "1.566" "1.071" "590.7" "642.1" "643.0" "657.2" "715.4" "718.4" "839.4" "918.2" "925.2" "632.5" "" "" "" "" "" "" "" "" "" "" "312.8" "356.0" "368.3" "302.7" "387.1" "399.6" "494.0" "501.2" "519.0" "632.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8706245126759521959" "False" "High" "IsMasterProtein" "Q9BRP4" "Proteasomal ATPase-associated factor 1 OS=Homo sapiens OX=9606 GN=PAAF1 PE=1 SV=2" "0.000" "False" "16.663" "10" "4" "5" "4" "392" "42.2" "6.32" "14.54" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf00400" "80227" "ENSG00000175575" "PAAF1" "A6NDR5; B4DPB0; B7ZAS9; hsa:80227; Q4G165; Q53HS9; Q7Z500; Q8TBU6; Q9BRP4; Q9HAB6" "" "" "0" "0" "0.997" "1.011" "1.063" "1.044" "1.079" "1.007" "0.929" "0.999" "1.020" "382.5" "381.5" "386.7" "406.5" "399.2" "412.6" "385.1" "355.4" "382.0" "390.0" "" "" "" "" "" "" "" "" "" "" "202.5" "211.5" "221.4" "187.2" "216.0" "229.5" "226.7" "194.0" "214.3" "390.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6567734872650185245" "False" "High" "IsMasterProtein" "C9JLW8" "Mapk-regulated corepressor-interacting protein 1 OS=Homo sapiens OX=9606 GN=MCRIP1 PE=1 SV=1" "0.000" "False" "16.654" "36" "3" "7" "3" "97" "10.9" "9.41" "23.98" "3" "other biological processes" "nucleus;other cell component" "" "Pf14799" "348262" "ENSG00000225663; ENSG00000288213" "MCRIP1" "C9JLW8; hsa:348262; Q6ZUL0" "" "" "0" "0" "0.973" "1.054" "1.068" "0.980" "0.868" "1.001" "0.929" "0.953" "0.573" "241.8" "235.3" "255.0" "258.3" "237.0" "209.9" "242.1" "224.7" "230.4" "138.5" "" "" "" "" "" "" "" "" "" "" "128.0" "130.4" "146.0" "118.9" "128.2" "116.7" "142.5" "122.7" "129.3" "138.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3531814392904203237" "False" "High" "IsMasterProtein" "P09884" "DNA polymerase alpha catalytic subunit OS=Homo sapiens OX=9606 GN=POLA1 PE=1 SV=2" "0.000" "False" "16.650" "4" "5" "6" "5" "1462" "165.8" "5.85" "14.58" "5" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00136, Pf03104, Pf08996, Pf12254" "5422" "ENSG00000101868" "POLA1" "hsa:5422; P09884; Q86UQ7" "Retinoblastoma gene in cancer; Pyrimidine metabolism; DNA replication" "Activation of the pre-replicative complex; Defective pyroptosis; G1/S-Specific Transcription; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; DNA replication initiation; Polymerase switching; Removal of the Flap Intermediate" "13" "0" "0.891" "0.933" "1.142" "1.128" "1.147" "1.769" "1.667" "1.757" "4.504" "258.1" "230.1" "241.0" "294.9" "291.1" "296.1" "456.7" "430.2" "453.5" "1162.8" "" "" "" "" "" "" "" "" "" "" "136.7" "127.5" "138.0" "135.8" "157.5" "164.7" "268.8" "234.8" "254.4" "1162.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-309007205683403427" "False" "High" "IsMasterProtein" "Q8IWS0" "PHD finger protein 6 OS=Homo sapiens OX=9606 GN=PHF6 PE=1 SV=1" "0.000" "False" "16.634" "13" "4" "6" "4" "365" "41.3" "8.68" "11.38" "4" "developmental processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf13771" "84295" "ENSG00000156531" "PHF6" "A8K230; B4E0G4; D3DTG3; E9PC97; hsa:84295; Q5JRC7; Q5JRC8; Q8IWS0; Q96JK3; Q9BRU0" "Mesodermal commitment pathway" "" "1" "0" "0.952" "1.091" "0.988" "1.050" "1.091" "1.043" "1.009" "1.113" "2.278" "333.1" "317.0" "363.4" "329.0" "349.6" "363.5" "347.5" "336.0" "370.6" "758.7" "" "" "" "" "" "" "" "" "" "" "176.4" "175.7" "208.1" "151.5" "189.1" "202.2" "204.5" "183.4" "207.9" "758.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5348588292702008792" "False" "High" "IsMasterProtein" "O94888" "UBX domain-containing protein 7 OS=Homo sapiens OX=9606 GN=UBXN7 PE=1 SV=2" "0.000" "False" "16.623" "11" "6" "8" "6" "489" "54.8" "5.16" "22.54" "6" "protein metabolism;other metabolic processes" "other membranes;cytosol;ER/Golgi;nucleus" "other molecular function" "Pf00789, Pf13899, Pf14555" "26043" "ENSG00000163960" "UBXN7" "D3DXB3; hsa:26043; O94888; Q6ZP77; Q86X20; Q8N327" "3q29 copy number variation syndrome" "Neddylation; KEAP1-NFE2L2 pathway" "3" "0" "1.066" "1.109" "1.076" "1.107" "1.150" "1.161" "1.160" "1.191" "0.927" "853.4" "909.6" "946.6" "918.4" "944.7" "981.8" "991.0" "989.9" "1016.4" "790.8" "" "" "" "" "" "" "" "" "" "" "451.9" "504.3" "542.1" "423.0" "511.1" "546.1" "583.2" "540.3" "570.2" "790.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9137773696009286865" "False" "High" "IsMasterProtein" "P58546" "Myotrophin OS=Homo sapiens OX=9606 GN=MTPN PE=1 SV=2" "0.000" "False" "16.612" "29" "3" "5" "3" "118" "12.9" "5.52" "16.25" "3" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf12796" "136319" "ENSG00000105887" "MTPN" "hsa:136319; P58546" "" "" "0" "0" "0.957" "1.046" "1.174" "0.907" "0.958" "1.048" "1.162" "1.010" "1.423" "689.5" "660.0" "721.5" "809.4" "625.4" "660.8" "722.4" "801.6" "696.1" "981.5" "" "" "" "" "" "" "" "" "" "" "365.1" "365.9" "413.2" "372.8" "338.4" "367.6" "425.2" "437.5" "390.5" "981.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4517606527837170781" "False" "High" "IsMasterProtein" "Q9Y5P6" "Mannose-1-phosphate guanyltransferase beta OS=Homo sapiens OX=9606 GN=GMPPB PE=1 SV=2" "0.000" "False" "16.593" "15" "4" "5" "4" "360" "39.8" "6.61" "14.44" "4" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00132, Pf00483" "29925" "ENSG00000173540" "GMPPB" "A8K6N5; hsa:29925; Q9H7U3; Q9Y5P6" "N-glycan biosynthesis" "Synthesis of GDP-mannose" "2" "0" "1.383" "1.152" "1.203" "1.112" "1.122" "1.234" "1.179" "1.121" "0.638" "412.4" "570.3" "475.0" "496.0" "458.4" "462.8" "509.1" "486.3" "462.5" "263.2" "" "" "" "" "" "" "" "" "" "" "218.4" "316.2" "272.0" "228.4" "248.0" "257.4" "299.6" "265.4" "259.4" "263.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "978357741075337008" "False" "High" "IsMasterProtein" "Q6UN15" "Pre-mRNA 3'-end-processing factor FIP1 OS=Homo sapiens OX=9606 GN=FIP1L1 PE=1 SV=1" "0.000" "False" "16.586" "8" "4" "6" "4" "594" "66.5" "5.59" "14.62" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "" "Pf05182" "81608" "ENSG00000145216" "FIP1L1" "B4DIR3; G3XAD6; hsa:81608; Q0VGE0; Q499Y4; Q49AU3; Q6UN15; Q7Z608; Q8WVN3; Q96F80; Q9H077" "" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins" "6" "0" "1.057" "1.035" "0.945" "1.215" "1.127" "1.620" "1.820" "1.735" "1.297" "282.4" "298.4" "292.1" "266.8" "343.2" "318.1" "457.5" "513.8" "489.7" "366.2" "" "" "" "" "" "" "" "" "" "" "149.5" "165.4" "167.3" "122.9" "185.7" "176.9" "269.2" "280.5" "274.7" "366.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4048246386295190521" "False" "High" "IsMasterProtein" "Q9Y6E0" "Serine/threonine-protein kinase 24 OS=Homo sapiens OX=9606 GN=STK24 PE=1 SV=1" "0.000" "False" "16.566" "9" "4" "4" "3" "443" "49.3" "5.69" "12.73" "4" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf20929" "8428" "ENSG00000102572" "STK24" "hsa:8428; O14840; Q5JV92; Q9Y6E0" "" "Apoptotic cleavage of cellular proteins" "2" "1" "0.971" "1.026" "0.948" "1.118" "1.134" "0.895" "0.941" "1.013" "0.778" "847.9" "823.3" "869.8" "804.2" "947.8" "961.9" "758.5" "797.5" "859.3" "659.6" "" "" "" "" "" "" "" "" "" "" "449.0" "456.5" "498.1" "370.4" "512.8" "535.1" "446.4" "435.3" "482.1" "659.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5490413544944086937" "False" "High" "IsMasterProtein" "Q9BPX5" "Actin-related protein 2/3 complex subunit 5-like protein OS=Homo sapiens OX=9606 GN=ARPC5L PE=1 SV=1" "0.000" "False" "16.563" "32" "5" "7" "5" "153" "16.9" "6.60" "19.05" "5" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf04699" "81873" "ENSG00000136950" "ARPC5L" "hsa:81873; Q7Z523; Q9BPX5" "Pathogenic Escherichia coli infection; VEGFA-VEGFR2 signaling" "" "2" "0" "0.979" "1.030" "0.898" "0.830" "0.890" "0.858" "0.932" "0.977" "0.528" "1385.7" "1356.1" "1428.0" "1244.0" "1149.7" "1232.9" "1188.4" "1290.8" "1354.0" "731.5" "" "" "" "" "" "" "" "" "" "" "733.7" "751.9" "817.8" "572.9" "622.0" "685.8" "699.4" "704.6" "759.5" "731.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5379927886480691395" "False" "High" "IsMasterProtein" "O95456" "Proteasome assembly chaperone 1 OS=Homo sapiens OX=9606 GN=PSMG1 PE=1 SV=1" "0.000" "False" "16.521" "16" "4" "5" "4" "288" "32.8" "7.17" "15.67" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf16094" "8624" "ENSG00000183527" "PSMG1" "B5BUN2; hsa:8624; O95456; Q6FHA3; Q6FHD3; Q6S713" "" "" "0" "0" "1.213" "0.970" "1.151" "1.097" "1.006" "1.062" "1.005" "0.991" "0.576" "283.3" "343.8" "274.7" "326.2" "310.9" "284.9" "300.9" "284.8" "280.8" "163.3" "" "" "" "" "" "" "" "" "" "" "150.0" "190.6" "157.3" "150.2" "168.2" "158.5" "177.1" "155.5" "157.5" "163.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4678408440687391789" "False" "High" "IsMasterProtein" "Q9UFW8" "CGG triplet repeat-binding protein 1 OS=Homo sapiens OX=9606 GN=CGGBP1 PE=1 SV=2" "0.000" "False" "16.499" "25" "4" "5" "4" "167" "18.8" "8.95" "15.23" "4" "cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "8545" "ENSG00000163320" "CGGBP1" "D3DU38; hsa:8545; O15183; Q9UFW8" "" "" "0" "0" "1.103" "1.098" "1.146" "1.033" "1.011" "1.035" "1.143" "1.017" "0.825" "531.4" "586.4" "583.7" "609.2" "548.8" "537.0" "549.7" "607.4" "540.2" "438.6" "" "" "" "" "" "" "" "" "" "" "281.4" "325.1" "334.3" "280.5" "296.9" "298.7" "323.5" "331.5" "303.0" "438.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3715797868298302435" "False" "High" "IsMasterProtein" "Q5ST30" "Valine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=VARS2 PE=1 SV=2" "0.000" "False" "16.485" "5" "5" "5" "5" "1063" "118.4" "7.02" "12.33" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00133, Pf08264" "57176" "ENSG00000137411; ENSG00000223494" "VARS2" "A2ABL7; B4DET4; B4E3P5; F5GXJ0; F5H323; hsa:57176; Q2M2A0; Q59FI1; Q5SQ96; Q5SS98; Q5ST30; Q6DKJ5; Q6ZV24; Q96GN2; Q96H77; Q96Q02; Q9H6R2; Q9UFH7" "" "Mitochondrial tRNA aminoacylation" "1" "0" "1.000" "1.049" "1.078" "1.132" "1.094" "0.953" "0.914" "1.040" "0.891" "656.4" "656.7" "688.9" "707.5" "743.1" "718.4" "625.8" "600.1" "682.7" "584.6" "" "" "" "" "" "" "" "" "" "" "347.6" "364.1" "394.5" "325.8" "402.0" "399.6" "368.3" "327.6" "383.0" "584.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "727638957837399757" "False" "High" "IsMasterProtein" "O15014" "Zinc finger protein 609 OS=Homo sapiens OX=9606 GN=ZNF609 PE=1 SV=2" "0.000" "False" "16.482" "3" "4" "5" "4" "1411" "151.1" "8.03" "12.57" "4" "other biological processes" "nucleus" "other molecular function" "" "23060" "ENSG00000180357" "ZNF609" "hsa:23060; O15014; Q0D2I2" "" "" "0" "0" "0.966" "0.966" "1.245" "1.165" "1.179" "1.469" "1.421" "1.558" "1.667" "151.5" "146.4" "146.3" "188.6" "176.6" "178.6" "222.6" "215.3" "236.0" "252.6" "" "" "" "" "" "" "" "" "" "" "80.2" "81.2" "83.8" "86.9" "95.5" "99.3" "131.0" "117.5" "132.4" "252.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3464884523288308990" "False" "High" "IsMasterProtein" "Q12972" "Nuclear inhibitor of protein phosphatase 1 OS=Homo sapiens OX=9606 GN=PPP1R8 PE=1 SV=2" "0.000" "False" "16.430" "9" "3" "3" "3" "351" "38.5" "7.37" "9.36" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00498" "5511" "ENSG00000117751" "PPP1R8" "hsa:5511; Q12972; Q5TEJ2; Q5TEJ4; Q5TIF2; Q6PKF6; Q9UBH1; Q9UBZ0" "" "mRNA Splicing - Major Pathway" "1" "0" "0.822" "0.973" "1.224" "0.950" "0.966" "1.448" "1.399" "1.371" "1.134" "136.9" "112.6" "133.2" "167.6" "130.1" "132.2" "198.2" "191.5" "187.7" "155.2" "" "" "" "" "" "" "" "" "" "" "72.5" "62.4" "76.3" "77.2" "70.4" "73.5" "116.6" "104.5" "105.3" "155.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8978349436204480078" "False" "High" "IsMasterProtein" "Q13148" "TAR DNA-binding protein 43 OS=Homo sapiens OX=9606 GN=TARDBP PE=1 SV=1" "0.000" "False" "16.378" "10" "4" "4" "4" "414" "44.7" "6.19" "12.29" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf18694, Pf20910" "23435" "ENSG00000120948" "TARDBP" "A4GUK4; A4GUK5; A4GUK6; B2R629; B4DJ45; E2PU12; hsa:23435; Q13148; Q53H27; Q6FI92; Q96DJ0" "MECP2 and associated Rett syndrome; HDAC6 interactions in the central nervous system" "" "2" "0" "1.013" "0.893" "0.882" "0.970" "1.009" "1.058" "0.282" "0.960" "10.835" "333.3" "337.5" "297.8" "294.0" "323.3" "336.3" "352.5" "93.9" "319.8" "3611.5" "" "" "" "" "" "" "" "" "" "" "176.5" "187.1" "170.5" "135.4" "174.9" "187.1" "207.5" "51.3" "179.4" "3611.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3104846382151978420" "False" "High" "IsMasterProtein" "Q9UKY7" "Protein CDV3 homolog OS=Homo sapiens OX=9606 GN=CDV3 PE=1 SV=1" "0.000" "False" "16.369" "17" "4" "7" "4" "258" "27.3" "6.40" "20.30" "4" "" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf15359" "55573" "ENSG00000091527" "CDV3" "B3KUC2; hsa:55573; Q96IP9; Q9UKY7" "" "" "0" "0" "1.015" "1.053" "1.116" "0.742" "0.879" "0.755" "1.122" "0.769" "0.458" "1374.7" "1394.6" "1447.2" "1533.9" "1019.5" "1208.2" "1037.8" "1542.4" "1057.6" "629.0" "" "" "" "" "" "" "" "" "" "" "727.9" "773.2" "828.8" "706.4" "551.6" "672.0" "610.8" "841.9" "593.3" "629.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3306595998206250770" "False" "High" "IsMasterProtein" "P62753" "Small ribosomal subunit protein eS6 OS=Homo sapiens OX=9606 GN=RPS6 PE=1 SV=1" "0.000" "False" "16.361" "14" "4" "6" "4" "249" "28.7" "10.84" "17.96" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01092" "6194" "ENSG00000137154" "RPS6" "hsa:6194; P08227; P10660; P62753; Q4VBY7; Q8N6Z7" "IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Hereditary leiomyomatosis and renal cell carcinoma pathway; Thermogenesis; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; IL-2 signaling pathway; Pleural mesothelioma; 2q37 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways" "SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SARS-CoV-2 modulates host translation machinery; Protein hydroxylation; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; mTORC1-mediated signalling; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nuclear events stimulated by ALK signaling in cancer; SARS-CoV-1 modulates host translation machinery" "49" "0" "1.072" "1.151" "1.421" "0.954" "0.993" "1.035" "1.267" "1.150" "1.854" "362.0" "388.0" "416.8" "514.4" "345.5" "359.5" "374.8" "458.6" "416.2" "671.4" "" "" "" "" "" "" "" "" "" "" "191.7" "215.1" "238.7" "236.9" "186.9" "200.0" "220.6" "250.4" "233.5" "671.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "721169718826189063" "False" "High" "IsMasterProtein" "Q8IX12" "Cell division cycle and apoptosis regulator protein 1 OS=Homo sapiens OX=9606 GN=CCAR1 PE=1 SV=2" "0.000" "False" "16.349" "5" "7" "8" "6" "1150" "132.7" "5.76" "19.45" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf14443, Pf14444, Pf19256, Pf19257" "55749" "ENSG00000060339" "CCAR1" "A0JLT7; A1L4P7; A8K9D4; B4DNP8; B4DRK8; hsa:55749; Q32NE3; Q5EBM3; Q5VUP6; Q6PIZ0; Q6X935; Q8IX12; Q9H8N4; Q9NVA7; Q9NVQ0; Q9NWM6" "" "mRNA Splicing - Major Pathway" "1" "1" "1.056" "1.001" "1.069" "1.026" "1.006" "0.949" "0.939" "1.003" "1.552" "501.1" "529.1" "501.5" "535.9" "514.2" "504.3" "475.4" "470.8" "502.6" "777.6" "" "" "" "" "" "" "" "" "" "" "265.3" "293.3" "287.2" "246.8" "278.2" "280.5" "279.8" "257.0" "282.0" "777.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3310116821494939621" "False" "High" "IsMasterProtein" "O00584" "Ribonuclease T2 OS=Homo sapiens OX=9606 GN=RNASET2 PE=1 SV=2" "0.000" "False" "16.346" "12" "3" "7" "3" "256" "29.5" "7.08" "16.35" "3" "RNA metabolism OR transcription;other metabolic processes;stress response" "non-structural extracellular;mitochondrion;ER/Golgi;other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf00445" "8635" "ENSG00000026297" "RNASET2" "B2RDA7; E1P5C3; hsa:8635; O00584; Q5T8Q0; Q8TCU2; Q9BZ46; Q9BZ47" "" "Neutrophil degranulation" "1" "0" "0.909" "1.077" "0.911" "0.890" "0.918" "0.899" "0.941" "0.925" "0.461" "406.7" "369.8" "437.9" "370.5" "361.9" "373.5" "365.7" "382.6" "376.2" "187.4" "" "" "" "" "" "" "" "" "" "" "215.3" "205.0" "250.8" "170.6" "195.8" "207.7" "215.2" "208.8" "211.0" "187.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "621637110793391590" "False" "High" "IsMasterProtein" "Q9BV79" "Enoyl-[acyl-carrier-protein] reductase, mitochondrial OS=Homo sapiens OX=9606 GN=MECR PE=1 SV=2" "0.000" "False" "16.340" "12" "5" "6" "5" "373" "40.4" "8.76" "17.88" "5" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00107, Pf08240" "51102" "ENSG00000116353" "MECR" "B3KT72; Q5SYU0; Q5SYU1; Q5SYU2; Q6IBU9; Q9BV79; Q9Y373" "Fatty acid biosynthesis; Mitochondrial fatty acid synthesis pathway" "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA" "3" "0" "1.060" "0.986" "1.032" "1.059" "1.069" "0.956" "0.942" "0.943" "0.598" "941.3" "997.6" "928.3" "971.3" "996.6" "1006.2" "900.0" "887.1" "887.9" "562.8" "" "" "" "" "" "" "" "" "" "" "498.4" "553.1" "531.6" "447.3" "539.2" "559.7" "529.7" "484.2" "498.1" "562.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8778470671322458913" "False" "High" "IsMasterProtein" "Q71UI9" "Histone H2A.V OS=Homo sapiens OX=9606 GN=H2AZ2 PE=1 SV=3" "0.000" "False" "16.319" "20" "3" "11" "1" "128" "13.5" "10.58" "25.53" "3" "cell organization and biogenesis" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125, Pf16211" "94239" "ENSG00000105968" "H2AZ2" "A6NFA8; A6NKY0; A6NN01; A8MQC5; hsa:94239; Q59GV8; Q6PK98; Q71UI9" "FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma" "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Transcriptional regulation by small RNAs; RUNX1 regulates transcription of genes involved in differentiation of HSCs; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Condensation of Prophase Chromosomes; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Meiotic synapsis; Deposition of new CENPA-containing nucleosomes at the centromere; RMTs methylate histone arginines; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; DNA Damage/Telomere Stress Induced Senescence" "35" "0" "1.048" "1.098" "1.421" "1.066" "1.103" "1.289" "0.816" "1.248" "4.360" "161.1" "168.9" "177.0" "229.0" "171.7" "177.7" "207.8" "131.4" "201.0" "702.5" "" "" "" "" "" "" "" "" "" "" "85.3" "93.6" "101.4" "105.5" "92.9" "98.8" "122.3" "71.7" "112.8" "702.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4622690060897357887" "False" "High" "IsMasterProtein" "Q9UII2" "ATPase inhibitor, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5IF1 PE=1 SV=1" "0.000" "False" "16.310" "25" "4" "13" "4" "106" "12.2" "9.35" "33.50" "4" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf04568" "93974" "ENSG00000130770; ENSG00000285390" "ATP5IF1" "hsa:93974; Q5JXL8; Q6IAQ7; Q9BSL9; Q9UII2" "Electron transport chain: OXPHOS system in mitochondria" "" "1" "0" "0.975" "1.032" "0.955" "0.992" "0.915" "0.960" "0.978" "0.912" "0.572" "943.0" "919.4" "972.9" "901.0" "935.3" "862.5" "905.6" "922.7" "860.4" "539.7" "" "" "" "" "" "" "" "" "" "" "499.3" "509.7" "557.2" "415.0" "506.0" "479.7" "533.0" "503.7" "482.6" "539.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7175242905837588229" "False" "High" "IsMasterProtein" "O95747" "Serine/threonine-protein kinase OSR1 OS=Homo sapiens OX=9606 GN=OXSR1 PE=1 SV=1" "0.000" "False" "16.298" "8" "4" "6" "4" "527" "58.0" "6.43" "17.36" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12202" "9943" "ENSG00000172939" "OXSR1" "hsa:9943; O95747; Q3LR53; Q7Z501; Q9UPQ1" "" "" "0" "0" "1.011" "1.008" "1.052" "1.067" "1.156" "0.979" "0.602" "0.989" "4.659" "237.6" "240.2" "239.5" "250.0" "253.4" "274.7" "232.5" "143.1" "235.0" "1106.8" "" "" "" "" "" "" "" "" "" "" "125.8" "133.2" "137.1" "115.1" "137.1" "152.8" "136.8" "78.1" "131.8" "1106.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4037115124737055274" "False" "High" "IsMasterProtein" "P04439" "HLA class I histocompatibility antigen, A alpha chain OS=Homo sapiens OX=9606 GN=HLA-A PE=1 SV=2" "0.000" "False" "16.294" "18" "5" "7" "4" "365" "40.8" "6.00" "19.25" "5" "stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00129, Pf06623, Pf07654" "3105" "ENSG00000206503" "HLA-A" "B1PKZ3; hsa:3105; O02939; O02954; O02955; O02963; O19509; O19546; O19598; O19605; O19606; O19619; O19647; O19673; O19687; O19695; O19756; O19794; O19795; O43906; O43907; O46874; O62921; O62924; O77937; O77938; O77964; O78073; O78171; O98009; O98010; O98011; O98137; P01891; P01892; P04439; P05534; P06338; P10313; P10314; P10315; P10316; P13746; P16188; P16189; P16190; P18462; P30443; P30444; P30445; P30446; P30447; P30448; P30449; P30450; P30451; P30452; P30453; P30454; P30455; P30456; P30457; P30458; P30459; P30512; P30514; P79505; P79562; P79563; Q09160; Q29680; Q29747; Q29835; Q29837; Q29838; Q29899; Q29908; Q29909; Q29910; Q30208; Q31623; Q5S3G1; Q65A82; Q8MHM1; Q8MHN9; Q95352; Q95355; Q95362; Q95377; Q95380; Q95IZ5; Q9BCN0; Q9BD15; Q9BD19; Q9GJE6; Q9GJE7; Q9GJE8; Q9MW42; Q9MY89; Q9MYA3; Q9MYA5; Q9MYC4; Q9MYE6; Q9MYE9; Q9MYG4; Q9MYG5; Q9MYI5; Q9TP25; Q9TPQ3; Q9TPR8; Q9TPX8; Q9TPX9; Q9TPY0; Q9TQ24; Q9TQE8; Q9TQE9; Q9TQF1; Q9TQF5; Q9TQF8; Q9TQF9; Q9TQG0; Q9TQG5; Q9TQG7; Q9TQH5; Q9TQI3; Q9TQK5; Q9TQM6; Q9TQN5; Q9TQP5; Q9TQP6; Q9TQP7; Q9UIN1; Q9UIN2; Q9UIP7; Q9UQU3; Q9UQU6; Q9UQU7" "Proteasome degradation; Allograft rejection; Ebola virus infection in host; Cancer immunotherapy by PD-1 blockade; TAR syndrome" "E3 ubiquitin ligases ubiquitinate target proteins; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ER-Phagosome pathway; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interferon gamma signaling; Interferon alpha/beta signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Nef mediated downregulation of MHC class I complex cell surface expression; Endosomal/Vacuolar pathway" "14" "1" "1.024" "1.066" "0.987" "1.052" "1.100" "1.009" "1.095" "1.050" "0.469" "968.3" "991.7" "1032.4" "955.4" "1019.1" "1065.6" "977.4" "1060.3" "1016.4" "454.4" "" "" "" "" "" "" "" "" "" "" "512.7" "549.8" "591.2" "440.0" "551.4" "592.7" "575.2" "578.8" "570.2" "454.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2383613337026514959" "False" "High" "IsMasterProtein" "Q93052" "Lipoma-preferred partner OS=Homo sapiens OX=9606 GN=LPP PE=1 SV=1" "0.000" "False" "16.282" "7" "3" "4" "3" "612" "65.7" "7.37" "10.16" "3" "cell adhesion" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00412" "4026" "ENSG00000145012" "LPP" "A1L4L6; D3DNV6; hsa:4026; Q8NFX5; Q93052" "MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement" "" "1" "0" "1.011" "1.158" "1.219" "1.133" "1.151" "1.071" "1.114" "0.935" "0.762" "191.9" "194.0" "222.2" "233.8" "217.3" "220.8" "205.4" "213.8" "179.5" "146.1" "" "" "" "" "" "" "" "" "" "" "101.6" "107.5" "127.3" "107.7" "117.6" "122.8" "120.9" "116.7" "100.7" "146.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7331213768411445402" "False" "High" "IsMasterProtein" "O95777" "U6 snRNA-associated Sm-like protein LSm8 OS=Homo sapiens OX=9606 GN=LSM8 PE=1 SV=3" "0.000" "False" "16.267" "36" "3" "7" "3" "96" "10.4" "4.48" "16.55" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "51691" "ENSG00000128534" "LSM8" "hsa:51691; O95777" "" "mRNA Splicing - Major Pathway" "1" "0" "1.057" "0.971" "1.041" "0.990" "0.980" "1.067" "0.967" "0.999" "0.682" "311.0" "328.6" "301.9" "323.9" "307.8" "304.8" "331.8" "300.8" "310.8" "212.2" "" "" "" "" "" "" "" "" "" "" "164.7" "182.2" "172.9" "149.2" "166.5" "169.6" "195.2" "164.2" "174.3" "212.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3792046426100688845" "False" "High" "IsMasterProtein" "O43395" "U4/U6 small nuclear ribonucleoprotein Prp3 OS=Homo sapiens OX=9606 GN=PRPF3 PE=1 SV=2" "0.000" "False" "16.244" "7" "6" "7" "6" "683" "77.5" "9.50" "17.32" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01480, Pf06544, Pf08572" "9129" "ENSG00000117360" "PRPF3" "B4DSY9; hsa:9129; O43395; O43446; Q5VT54" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.017" "1.026" "1.138" "1.003" "1.121" "1.155" "0.818" "1.155" "3.610" "340.4" "346.2" "349.3" "387.4" "341.3" "381.5" "393.2" "278.3" "393.0" "1228.6" "" "" "" "" "" "" "" "" "" "" "180.2" "192.0" "200.0" "178.4" "184.7" "212.2" "231.4" "151.9" "220.5" "1228.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2190744193783032342" "False" "High" "IsMasterProtein" "Q92619" "Rho GTPase-activating protein 45 OS=Homo sapiens OX=9606 GN=ARHGAP45 PE=1 SV=2" "0.000" "False" "16.218" "4" "5" "5" "5" "1136" "124.5" "6.10" "14.78" "5" "signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00620" "23526" "ENSG00000180448" "ARHGAP45" "B4DTS4; F6QP70; hsa:23526; Q6P189; Q7LE26; Q86WS1; Q8HX84; Q92619; Q9GJN9; Q9GJP0; Q9GJP1; Q9MY24" "" "Neutrophil degranulation; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle" "4" "0" "1.095" "1.108" "1.047" "1.086" "1.138" "1.000" "0.925" "1.069" "1.795" "674.7" "738.8" "747.6" "706.6" "732.4" "767.5" "674.8" "624.0" "721.4" "1211.4" "" "" "" "" "" "" "" "" "" "" "357.2" "409.6" "428.1" "325.4" "396.3" "426.9" "397.1" "340.6" "404.7" "1211.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7662049170687489427" "False" "High" "IsMasterProtein" "Q9Y376" "Calcium-binding protein 39 OS=Homo sapiens OX=9606 GN=CAB39 PE=1 SV=1" "0.000" "False" "16.213" "15" "6" "6" "6" "341" "39.8" "6.89" "16.12" "6" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf08569" "51719" "ENSG00000135932" "CAB39" "A8K8L7; hsa:51719; Q9Y376" "AMP-activated protein kinase signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias" "Neutrophil degranulation; Energy dependent regulation of mTOR by LKB1-AMPK" "6" "0" "0.921" "0.968" "0.876" "0.895" "0.964" "0.843" "0.955" "0.864" "0.446" "1441.6" "1327.7" "1395.0" "1263.5" "1290.4" "1389.2" "1215.4" "1376.3" "1244.9" "643.2" "" "" "" "" "" "" "" "" "" "" "763.4" "736.1" "798.9" "581.9" "698.2" "772.8" "715.3" "751.3" "698.3" "643.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9194587147899025830" "False" "High" "IsMasterProtein" "P30613" "Pyruvate kinase PKLR OS=Homo sapiens OX=9606 GN=PKLR PE=1 SV=2" "0.000" "False" "16.191" "4" "3" "13" "1" "574" "61.8" "7.74" "39.51" "3" "other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00224, Pf02887" "5313" "ENSG00000143627; ENSG00000262785" "PKLR" "hsa:5313; O75758; P11973; P30613" "Clear cell renal cell carcinoma pathways; Nonalcoholic fatty liver disease; 7q11.23 copy number variation syndrome; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "" "5" "0" "1.257" "1.108" "1.183" "1.103" "1.113" "1.042" "1.097" "1.142" "0.911" "125.0" "157.1" "138.6" "147.9" "137.9" "139.1" "130.2" "137.2" "142.8" "113.9" "" "" "" "" "" "" "" "" "" "" "66.2" "87.1" "79.4" "68.1" "74.6" "77.4" "76.6" "74.9" "80.1" "113.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5457086219515973345" "False" "High" "IsMasterProtein" "P61086" "Ubiquitin-conjugating enzyme E2 K OS=Homo sapiens OX=9606 GN=UBE2K PE=1 SV=3" "0.000" "False" "16.186" "25" "5" "6" "5" "200" "22.4" "5.44" "11.01" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179, Pf00627" "3093" "ENSG00000078140" "UBE2K" "A6NJC1; A8K5Y9; B2RDF8; C9JGP1; hsa:3093; O54806; P27924; P61086; Q16721; Q9CVV9; Q9Y2D3" "" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Negative regulators of DDX58/IFIH1 signaling" "3" "0" "1.008" "1.057" "1.108" "1.109" "1.210" "1.046" "0.968" "1.245" "0.989" "334.1" "336.7" "353.3" "370.1" "370.6" "404.2" "349.4" "323.3" "415.9" "330.3" "" "" "" "" "" "" "" "" "" "" "176.9" "186.7" "202.3" "170.5" "200.5" "224.9" "205.6" "176.5" "233.3" "330.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5017693853216972141" "False" "High" "IsMasterProtein" "Q969S3" "Cytoplasmic 60S subunit biogenesis factor ZNF622 OS=Homo sapiens OX=9606 GN=ZNF622 PE=1 SV=1" "0.000" "False" "16.185" "12" "5" "6" "5" "477" "54.2" "6.15" "17.67" "5" "signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf12171, Pf12756" "90441" "ENSG00000173545" "ZNF622" "hsa:90441; Q969S3" "" "" "0" "0" "0.965" "0.967" "1.109" "1.164" "1.106" "1.716" "1.580" "1.554" "1.035" "326.6" "315.3" "315.9" "362.2" "380.2" "361.1" "560.4" "515.9" "507.4" "338.1" "" "" "" "" "" "" "" "" "" "" "172.9" "174.8" "180.9" "166.8" "205.7" "200.8" "329.8" "281.6" "284.6" "338.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8831328934271129534" "False" "High" "IsMasterProtein" "Q92733" "Proline-rich protein PRCC OS=Homo sapiens OX=9606 GN=PRCC PE=1 SV=1" "0.000" "False" "16.177" "8" "4" "5" "4" "491" "52.4" "5.10" "17.36" "4" "cell cycle OR cell proliferation;other biological processes" "nucleus" "" "Pf10253" "5546" "ENSG00000143294" "PRCC" "A8K1F7; hsa:5546; O00665; O00724; Q5SZ06; Q92733" "MET in type 1 papillary renal cell carcinoma; Type 2 papillary renal cell carcinoma; IL-18 signaling pathway" "mRNA Splicing - Major Pathway" "4" "0" "0.998" "1.051" "0.968" "1.037" "1.141" "0.963" "1.082" "1.075" "0.805" "501.9" "500.7" "527.3" "485.6" "520.5" "572.7" "483.2" "542.9" "539.5" "404.3" "" "" "" "" "" "" "" "" "" "" "265.8" "277.6" "302.0" "223.7" "281.6" "318.6" "284.4" "296.4" "302.6" "404.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4621514541592481866" "False" "High" "IsMasterProtein" "O75376" "Nuclear receptor corepressor 1 OS=Homo sapiens OX=9606 GN=NCOR1 PE=1 SV=2" "0.000" "False" "16.176" "3" "6" "6" "5" "2440" "270.0" "7.11" "11.26" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf15784" "9611" "ENSG00000141027" "NCOR1" "B3DLF8; E9PGV6; hsa:9611; O75376; Q86YY0; Q9UPV5; Q9UQ18" "Androgen receptor signaling pathway; Adipogenesis; Ovarian infertility; MECP2 and associated Rett syndrome; Pathways affected in adenoid cystic carcinoma; Rett syndrome; 22q11.2 copy number variation syndrome; Notch signaling pathway" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Nuclear signaling by ERBB4; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NR1D1 (REV-ERBA) represses gene expression; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis" "30" "1" "0.956" "1.012" "1.036" "1.015" "0.994" "1.173" "1.188" "1.240" "1.459" "567.4" "542.6" "574.1" "588.0" "575.9" "564.1" "665.4" "674.2" "703.4" "827.8" "" "" "" "" "" "" "" "" "" "" "300.4" "300.8" "328.8" "270.8" "311.6" "313.8" "391.6" "368.0" "394.6" "827.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4135876604710417259" "False" "High" "IsMasterProtein" "P49593" "Protein phosphatase 1F OS=Homo sapiens OX=9606 GN=PPM1F PE=1 SV=3" "0.000" "False" "16.173" "9" "4" "5" "4" "454" "49.8" "5.10" "15.60" "4" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00481" "9647" "ENSG00000100034" "PPM1F" "A8K6G3; B7Z2C3; hsa:9647; P49593; Q96PM2" "" "Negative regulation of NMDA receptor-mediated neuronal transmission" "1" "0" "1.035" "0.980" "1.086" "1.022" "1.007" "1.048" "0.944" "0.866" "0.974" "280.7" "290.5" "275.2" "304.7" "286.9" "282.5" "294.3" "264.8" "242.9" "273.4" "" "" "" "" "" "" "" "" "" "" "148.6" "161.1" "157.6" "140.3" "155.2" "157.2" "173.2" "144.6" "136.3" "273.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "295082137940750650" "False" "High" "IsMasterProtein" "O43633" "Charged multivesicular body protein 2a OS=Homo sapiens OX=9606 GN=CHMP2A PE=1 SV=1" "0.000" "False" "16.167" "13" "2" "4" "2" "222" "25.1" "5.97" "10.91" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "27243" "ENSG00000130724" "CHMP2A" "B2R4W6; hsa:27243; O43633; Q3ZTT0" "" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Lysosome Vesicle Biogenesis; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "10" "0" "1.065" "1.034" "1.094" "1.051" "1.064" "1.031" "1.125" "1.005" "0.631" "283.0" "301.3" "292.5" "309.6" "297.5" "301.0" "291.8" "318.3" "284.5" "178.5" "" "" "" "" "" "" "" "" "" "" "149.8" "167.1" "167.5" "142.6" "160.9" "167.4" "171.7" "173.8" "159.6" "178.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3366486650245995426" "False" "High" "IsMasterProtein" "P10515" "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLAT PE=1 SV=3" "0.000" "False" "16.156" "7" "6" "9" "6" "647" "69.0" "7.84" "24.14" "6" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00198, Pf00364, Pf02817" "1737" "ENSG00000150768" "DLAT" "hsa:1737; P10515; Q16783; Q53EP3" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "8" "0" "0.960" "1.004" "0.975" "0.957" "0.987" "0.964" "1.032" "0.975" "0.420" "1113.1" "1068.8" "1117.3" "1085.1" "1065.2" "1098.3" "1073.0" "1148.6" "1085.8" "467.7" "" "" "" "" "" "" "" "" "" "" "589.4" "592.6" "639.9" "499.7" "576.3" "610.9" "631.5" "627.0" "609.1" "467.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5687850324260335343" "False" "High" "IsMasterProtein" "Q16875" "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 OS=Homo sapiens OX=9606 GN=PFKFB3 PE=1 SV=1" "0.000" "False" "16.147" "11" "6" "8" "6" "520" "59.6" "8.21" "14.02" "6" "other metabolic processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00300, Pf01591" "5209" "ENSG00000170525" "PFKFB3" "B7Z955; hsa:5209; O43622; O75902; Q16875; Q5VX15; Q5VX18; Q5VX19" "AMP-activated protein kinase signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism" "3" "0" "1.024" "0.930" "1.081" "1.060" "1.065" "1.007" "1.008" "0.943" "0.717" "552.8" "566.2" "514.0" "597.6" "585.7" "588.8" "556.4" "557.3" "521.4" "396.5" "" "" "" "" "" "" "" "" "" "" "292.7" "313.9" "294.4" "275.2" "316.9" "327.5" "327.5" "304.2" "292.5" "396.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4258123771778816743" "False" "High" "IsMasterProtein" "P55265" "Double-stranded RNA-specific adenosine deaminase OS=Homo sapiens OX=9606 GN=ADAR PE=1 SV=4" "0.000" "False" "16.135" "4" "5" "7" "5" "1226" "136.0" "8.65" "16.73" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf02137, Pf02295" "103" "ENSG00000160710" "ADAR" "B1AQQ9; B1AQR0; D3DV76; hsa:103; O15223; O43859; O43860; P55265; Q9BYM3; Q9BYM4" "Measles virus infection; Cytosolic DNA-sensing pathway" "Interferon alpha/beta signaling; PKR-mediated signaling; C6 deamination of adenosine; Formation of editosomes by ADAR proteins" "6" "0" "0.850" "0.997" "1.054" "0.937" "0.966" "0.986" "0.739" "0.992" "3.696" "452.0" "384.1" "450.8" "476.3" "423.4" "436.6" "445.6" "334.1" "448.4" "1670.7" "" "" "" "" "" "" "" "" "" "" "239.3" "213.0" "258.2" "219.4" "229.1" "242.9" "262.3" "182.4" "251.5" "1670.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7123841880797263349" "False" "High" "IsMasterProtein" "P09382" "Galectin-1 OS=Homo sapiens OX=9606 GN=LGALS1 PE=1 SV=2" "0.000" "False" "16.119" "28" "4" "6" "4" "135" "14.7" "5.50" "15.85" "4" "cell adhesion;other biological processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00337" "3956" "ENSG00000100097" "LGALS1" "B2R5E8; hsa:3956; P09382; Q9UDK5" "Immune infiltration in pancreatic cancer" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "3" "0" "0.905" "0.972" "0.928" "0.937" "0.963" "0.974" "1.079" "1.001" "0.479" "864.5" "782.1" "840.7" "802.6" "810.0" "832.8" "841.7" "932.7" "865.3" "414.1" "" "" "" "" "" "" "" "" "" "" "457.8" "433.6" "481.5" "369.6" "438.2" "463.3" "495.4" "509.1" "485.4" "414.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7169835918379755143" "False" "High" "IsMasterProtein" "P39687" "Acidic leucine-rich nuclear phosphoprotein 32 family member A OS=Homo sapiens OX=9606 GN=ANP32A PE=1 SV=1" "0.000" "False" "16.114" "16" "6" "12" "4" "249" "28.6" "4.09" "22.27" "6" "transport;signal transduction;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf14580" "8125" "ENSG00000140350" "ANP32A" "B2R6T4; hsa:8125; P39687; Q53FK4; Q5J8L8; Q7M4N6" "IL-18 signaling pathway" "HuR (ELAVL1) binds and stabilizes mRNA" "2" "1" "1.070" "1.156" "1.062" "1.087" "1.024" "1.071" "1.090" "1.137" "0.936" "947.0" "1013.6" "1094.3" "1005.3" "1029.2" "969.6" "1014.5" "1032.1" "1076.8" "886.0" "" "" "" "" "" "" "" "" "" "" "501.5" "562.0" "626.7" "463.0" "556.8" "539.4" "597.1" "563.4" "604.1" "886.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2516150800733119915" "False" "High" "IsMasterProtein" "P55011" "Solute carrier family 12 member 2 OS=Homo sapiens OX=9606 GN=SLC12A2 PE=1 SV=1" "0.000" "False" "16.112" "5" "4" "5" "4" "1212" "131.4" "6.40" "10.50" "4" "cell-cell signaling;cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity;other molecular function" "Pf00324, Pf03522, Pf08403" "6558" "ENSG00000064651" "SLC12A2" "hsa:6558; P55011; Q8N713; Q8WWH7" "Polycystic kidney disease pathway" "Cation-coupled Chloride cotransporters" "2" "0" "0.964" "0.972" "1.067" "1.020" "0.907" "1.075" "1.028" "0.960" "0.533" "365.0" "351.7" "354.9" "389.6" "372.5" "331.1" "392.3" "375.2" "350.6" "194.5" "" "" "" "" "" "" "" "" "" "" "193.3" "195.0" "203.2" "179.4" "201.5" "184.2" "230.9" "204.8" "196.7" "194.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3113703590403153606" "False" "High" "IsMasterProtein" "Q96EP5" "DAZ-associated protein 1 OS=Homo sapiens OX=9606 GN=DAZAP1 PE=1 SV=1" "0.000" "False" "16.110" "9" "3" "7" "3" "407" "43.4" "8.56" "22.75" "3" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "26528" "ENSG00000071626" "DAZAP1" "hsa:26528; Q96EP5; Q96MJ3; Q9NRR9" "" "" "0" "0" "1.209" "1.350" "1.404" "1.265" "1.105" "1.036" "1.117" "1.067" "0.664" "66.4" "80.3" "89.6" "93.3" "84.0" "73.4" "68.8" "74.2" "70.8" "44.1" "" "" "" "" "" "" "" "" "" "" "35.2" "44.5" "51.3" "43.0" "45.5" "40.8" "40.5" "40.5" "39.7" "44.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5049018417817342026" "False" "High" "IsMasterProtein" "P09497" "Clathrin light chain B OS=Homo sapiens OX=9606 GN=CLTB PE=1 SV=1" "0.000" "False" "16.102" "15" "4" "7" "4" "229" "25.2" "4.64" "24.21" "4" "transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01086" "1212" "ENSG00000175416" "CLTB" "hsa:1212; P09497; Q53Y37; Q6FHW1" "Ebola virus infection in host; Fragile X syndrome; 5q35 copy number variation" "Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Formation of annular gap junctions" "11" "0" "0.993" "1.014" "0.996" "0.908" "0.923" "0.871" "0.909" "0.864" "0.507" "1204.8" "1196.5" "1222.1" "1200.5" "1094.4" "1111.8" "1049.8" "1094.9" "1040.5" "610.3" "" "" "" "" "" "" "" "" "" "" "637.9" "663.4" "699.9" "552.9" "592.1" "618.4" "617.9" "597.7" "583.7" "610.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1941852327752543049" "False" "High" "IsMasterProtein" "Q93009" "Ubiquitin carboxyl-terminal hydrolase 7 OS=Homo sapiens OX=9606 GN=USP7 PE=1 SV=2" "0.000" "False" "16.095" "5" "7" "7" "7" "1102" "128.2" "5.55" "17.43" "7" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf00917, Pf12436, Pf14533" "7874" "ENSG00000187555" "USP7" "A6NMY8; B7Z815; H0Y3G8; hsa:7874; Q93009" "Nucleotide excision repair in xeroderma pigmentosum ; Warburg effect modulated by deubiquitinating enzymes and their substrates" "Ub-specific processing proteases; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Regulation of TP53 Degradation; Formation of TC-NER Pre-Incision Complex; Regulation of PTEN localization" "10" "0" "0.972" "0.943" "0.981" "1.272" "1.029" "1.005" "0.370" "1.054" "8.004" "336.3" "326.9" "317.1" "329.9" "427.7" "346.0" "338.0" "124.3" "354.4" "2691.9" "" "" "" "" "" "" "" "" "" "" "178.1" "181.3" "181.6" "151.9" "231.4" "192.5" "198.9" "67.8" "198.8" "2691.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1176718520801112015" "False" "High" "IsMasterProtein" "P11441" "Ubiquitin-like protein 4A OS=Homo sapiens OX=9606 GN=UBL4A PE=1 SV=1" "0.000" "False" "16.093" "17" "3" "4" "3" "157" "17.8" "8.66" "12.08" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00240, Pf17840" "8266" "ENSG00000102178" "UBL4A" "hsa:8266; P11441; Q5HY80" "" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "1" "0" "1.056" "0.948" "1.155" "1.122" "1.214" "1.653" "1.655" "1.679" "1.499" "143.1" "151.1" "135.6" "165.3" "160.5" "173.7" "236.5" "236.8" "240.2" "214.5" "" "" "" "" "" "" "" "" "" "" "75.8" "83.8" "77.7" "76.1" "86.9" "96.6" "139.2" "129.3" "134.7" "214.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3931502688338012469" "False" "High" "IsMasterProtein" "P35249" "Replication factor C subunit 4 OS=Homo sapiens OX=9606 GN=RFC4 PE=1 SV=2" "0.000" "False" "16.092" "9" "3" "4" "3" "363" "39.7" "8.02" "14.18" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004, Pf08542" "5984" "ENSG00000163918" "RFC4" "B4DM41; D3DNV2; hsa:5984; P35249; Q6FHX7" "Gastric cancer network 2; Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Activation of ATR in response to replication stress; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "28" "0" "1.050" "1.030" "1.106" "1.140" "1.065" "0.903" "0.925" "0.998" "1.120" "507.3" "532.7" "522.5" "560.9" "578.3" "540.2" "458.0" "469.1" "506.3" "568.4" "" "" "" "" "" "" "" "" "" "" "268.6" "295.3" "299.3" "258.3" "312.9" "300.5" "269.6" "256.1" "284.0" "568.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-558081350695480590" "False" "High" "IsMasterProtein" "O43172" "U4/U6 small nuclear ribonucleoprotein Prp4 OS=Homo sapiens OX=9606 GN=PRPF4 PE=1 SV=2" "0.000" "False" "16.091" "7" "3" "4" "3" "522" "58.4" "7.42" "14.07" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00400, Pf08799" "9128" "ENSG00000136875" "PRPF4" "hsa:9128; O43172; O43445; O43864; Q5T1M8; Q96DG2; Q96IK4" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.972" "1.010" "1.048" "1.025" "1.102" "1.116" "0.871" "1.181" "3.365" "374.7" "364.4" "378.5" "392.6" "384.0" "413.0" "418.2" "326.4" "442.4" "1260.8" "" "" "" "" "" "" "" "" "" "" "198.4" "202.0" "216.8" "180.8" "207.7" "229.8" "246.1" "178.2" "248.2" "1260.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7862445690525938863" "False" "High" "IsMasterProtein" "P32455" "Guanylate-binding protein 1 OS=Homo sapiens OX=9606 GN=GBP1 PE=1 SV=2" "0.000" "False" "16.060" "9" "6" "8" "6" "592" "67.9" "6.32" "18.50" "6" "cell organization and biogenesis;stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf02263, Pf02841" "2633" "ENSG00000117228" "GBP1" "D3DT26; hsa:2633; P32455; Q5T8M1" "Type II interferon signaling" "Interferon gamma signaling" "2" "0" "1.071" "0.968" "0.970" "1.028" "1.075" "0.999" "0.897" "1.013" "2.885" "265.9" "284.8" "257.4" "258.0" "273.5" "286.0" "265.5" "238.5" "269.2" "767.2" "" "" "" "" "" "" "" "" "" "" "140.8" "157.9" "147.4" "118.8" "148.0" "159.1" "156.3" "130.2" "151.0" "767.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5370481134034691073" "False" "High" "IsMasterProtein" "P22307" "Sterol carrier protein 2 OS=Homo sapiens OX=9606 GN=SCP2 PE=1 SV=2" "0.000" "False" "16.057" "7" "4" "5" "4" "547" "59.0" "6.89" "14.12" "4" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf00108, Pf02036, Pf02803" "6342" "ENSG00000116171" "SCP2" "A6NM69; B4DGJ9; B4DHP6; C9JC79; D3DQ37; E1B6W5; F2Z3J1; hsa:6342; P22307; Q15432; Q16622; Q5VVZ1; Q6NXF4; Q99430" "PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Mitochondrial fatty acid oxidation disorders; DNA damage response (only ATM dependent)" "TYSND1 cleaves peroxisomal proteins; alpha-linolenic acid (ALA) metabolism" "10" "0" "1.019" "1.102" "0.865" "1.004" "0.951" "0.870" "1.071" "1.009" "0.471" "868.5" "884.9" "957.1" "751.0" "871.8" "825.8" "755.7" "930.0" "876.6" "409.5" "" "" "" "" "" "" "" "" "" "" "459.9" "490.6" "548.1" "345.9" "471.7" "459.4" "444.8" "507.6" "491.8" "409.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6087199310060456450" "False" "High" "IsMasterProtein" "Q9UI30" "Multifunctional methyltransferase subunit TRM112-like protein OS=Homo sapiens OX=9606 GN=TRMT112 PE=1 SV=1" "0.000" "False" "16.033" "17" "2" "4" "2" "125" "14.2" "5.26" "14.27" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03966" "51504" "ENSG00000173113" "TRMT112" "B2R539; hsa:51504; J3KNG5; Q3MHC7; Q8N2Z4; Q9UI30" "" "Eukaryotic Translation Termination; rRNA modification in the nucleus and cytosol; tRNA modification in the nucleus and cytosol; Methylation" "4" "0" "1.161" "1.111" "1.147" "1.063" "1.042" "1.043" "1.095" "0.974" "0.710" "481.2" "558.8" "534.5" "552.0" "511.4" "501.3" "501.8" "527.0" "468.7" "341.5" "" "" "" "" "" "" "" "" "" "" "254.8" "309.8" "306.1" "254.2" "276.7" "278.9" "295.3" "287.7" "262.9" "341.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1414945439185658993" "False" "High" "IsMasterProtein" "P84090" "Enhancer of rudimentary homolog OS=Homo sapiens OX=9606 GN=ERH PE=1 SV=1" "0.000" "False" "16.028" "34" "3" "5" "3" "104" "12.3" "5.92" "10.17" "3" "cell cycle OR cell proliferation;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01133" "2079" "ENSG00000100632" "ERH" "B2R5H2; hsa:2079; P70659; P84090; Q14259" "" "" "0" "0" "0.964" "1.179" "1.106" "0.930" "1.035" "1.106" "1.217" "1.105" "0.480" "863.7" "832.6" "1018.2" "955.3" "803.7" "894.0" "955.5" "1051.2" "954.4" "414.2" "" "" "" "" "" "" "" "" "" "" "457.3" "461.6" "583.1" "440.0" "434.8" "497.3" "562.4" "573.8" "535.4" "414.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4570733689934674061" "False" "High" "IsMasterProtein" "P61106" "Ras-related protein Rab-14 OS=Homo sapiens OX=9606 GN=RAB14 PE=1 SV=4" "0.000" "False" "16.027" "24" "5" "6" "5" "215" "23.9" "6.21" "18.17" "5" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "51552" "ENSG00000119396" "RAB14" "B3KR31; hsa:51552; P35287; P61106; Q5JVD4; Q6Q7K5; Q969L0; Q9UI11" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape" "RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Neutrophil degranulation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Synthesis of PIPs at the plasma membrane" "7" "0" "0.955" "0.899" "0.921" "0.926" "1.022" "0.987" "0.971" "0.916" "0.602" "1414.4" "1350.8" "1271.0" "1302.7" "1309.4" "1445.0" "1396.3" "1372.9" "1295.5" "851.1" "" "" "" "" "" "" "" "" "" "" "748.9" "748.9" "727.9" "599.9" "708.4" "803.8" "821.8" "749.4" "726.8" "851.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2243304084648640018" "False" "High" "IsMasterProtein" "P49585" "Choline-phosphate cytidylyltransferase A OS=Homo sapiens OX=9606 GN=PCYT1A PE=1 SV=2" "0.000" "False" "16.017" "21" "7" "8" "7" "367" "41.7" "7.25" "13.52" "7" "other metabolic processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01467" "5130" "ENSG00000161217" "PCYT1A" "A9LYK9; D3DXB1; hsa:5130; P49585; Q86Y88" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids; 3q29 copy number variation syndrome; Acetylcholine synthesis" "Synthesis of PC" "7" "0" "0.974" "0.964" "1.152" "1.090" "1.058" "1.114" "0.981" "0.999" "1.235" "384.1" "374.3" "370.4" "442.4" "418.8" "406.6" "427.8" "376.9" "383.9" "474.3" "" "" "" "" "" "" "" "" "" "" "203.4" "207.5" "212.1" "203.7" "226.6" "226.1" "251.8" "205.7" "215.3" "474.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "212659989141045460" "False" "High" "IsMasterProtein" "P78356" "Phosphatidylinositol 5-phosphate 4-kinase type-2 beta OS=Homo sapiens OX=9606 GN=PIP4K2B PE=1 SV=1" "0.000" "False" "16.011" "14" "5" "6" "4" "416" "47.3" "7.33" "16.48" "5" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle" "kinase activity;other molecular function" "Pf01504" "8396" "ENSG00000276293; ENSG00000277292" "PIP4K2B" "hsa:8396; P78356; Q5U0E8; Q8TBP2" "Regulation of actin cytoskeleton; 17q12 copy number variation syndrome" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus" "6" "1" "1.024" "1.030" "0.938" "1.055" "1.131" "1.021" "0.951" "1.044" "1.237" "342.0" "350.1" "352.3" "320.8" "360.7" "386.7" "349.0" "325.2" "357.2" "423.1" "" "" "" "" "" "" "" "" "" "" "181.1" "194.1" "201.7" "147.7" "195.1" "215.1" "205.4" "177.5" "200.4" "423.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "456544607600152383" "False" "High" "IsMasterProtein" "Q9UJY5" "ADP-ribosylation factor-binding protein GGA1 OS=Homo sapiens OX=9606 GN=GGA1 PE=1 SV=1" "0.000" "False" "15.962" "6" "5" "5" "5" "639" "70.3" "5.29" "14.28" "5" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf02883, Pf03127, Pf18308" "26088" "ENSG00000100083" "GGA1" "A8K3D3; B0QYR7; hsa:26088; Q5R3N1; Q5TG07; Q6IC75; Q86YA9; Q8NCS6; Q9BW94; Q9UG00; Q9UGW0; Q9UGW1; Q9UJY5" "" "Amyloid fiber formation; TBC/RABGAPs" "2" "0" "1.080" "1.087" "1.127" "1.048" "1.008" "1.059" "1.130" "1.058" "1.232" "758.6" "819.0" "824.4" "855.1" "795.2" "764.6" "803.6" "857.2" "802.4" "934.3" "" "" "" "" "" "" "" "" "" "" "401.7" "454.1" "472.1" "393.8" "430.3" "425.3" "472.9" "467.9" "450.1" "934.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5999519850232784779" "False" "High" "IsMasterProtein" "Q9Y3L3" "SH3 domain-binding protein 1 OS=Homo sapiens OX=9606 GN=SH3BP1 PE=1 SV=3" "0.000" "False" "15.956" "4" "3" "4" "3" "701" "75.7" "6.77" "13.41" "3" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00620, Pf03114" "23616" "ENSG00000100092" "SH3BP1" "hsa:23616; Q5R3N0; Q6IBZ2; Q6ZVL9; Q96HQ5; Q9NSQ9; Q9Y3L3" "" "RAC1 GTPase cycle" "1" "0" "0.974" "0.822" "0.906" "0.929" "0.909" "0.736" "0.717" "0.793" "0.821" "290.9" "283.2" "239.2" "263.5" "270.2" "264.3" "214.1" "208.6" "230.6" "239.0" "" "" "" "" "" "" "" "" "" "" "154.0" "157.0" "137.0" "121.4" "146.2" "147.0" "126.0" "113.9" "129.4" "239.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-938207872866175487" "False" "High" "IsMasterProtein" "Q00534" "Cyclin-dependent kinase 6 OS=Homo sapiens OX=9606 GN=CDK6 PE=1 SV=1" "0.000" "False" "15.951" "13" "4" "7" "3" "326" "36.9" "6.46" "16.88" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1021" "ENSG00000105810" "CDK6" "A4D1G0; hsa:1021; Q00534" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Metastatic brain tumor; Glioblastoma signaling pathways; Retinoblastoma gene in cancer; Wnt signaling pathway; PI3K-Akt signaling pathway; Tumor suppressor activity of SMARCB1; Non-small cell lung cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Influence of laminopathies on Wnt signaling; DYRK1A involvement regarding cell proliferation in brain development; DNA damage response" "Oxidative Stress Induced Senescence; Oncogene Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Drug-mediated inhibition of CDK4/CDK6 activity; Regulation of RUNX1 Expression and Activity" "30" "0" "0.936" "0.914" "1.035" "0.913" "1.048" "0.919" "0.835" "0.896" "1.651" "168.6" "157.8" "154.1" "174.5" "153.9" "176.8" "155.0" "140.7" "151.1" "278.4" "" "" "" "" "" "" "" "" "" "" "89.3" "87.5" "88.3" "80.4" "83.3" "98.3" "91.2" "76.8" "84.8" "278.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-381937601164646059" "False" "High" "IsMasterProtein" "Q15257" "Serine/threonine-protein phosphatase 2A activator OS=Homo sapiens OX=9606 GN=PTPA PE=1 SV=3" "0.000" "False" "15.949" "16" "6" "11" "6" "358" "40.6" "5.94" "23.20" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf03095" "5524" "ENSG00000119383" "PTPA" "A2A347; A9IZU4; B4DXM4; hsa:5524; Q15257; Q15258; Q53GZ3; Q5TZQ2; Q9BUK1; Q9NNZ7; Q9NNZ8; Q9NNZ9" "Interleukin-11 signaling pathway; Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; Wnt signaling pathway and pluripotency; Netrin-UNC5B signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "" "7" "0" "0.951" "1.052" "0.919" "0.889" "0.966" "0.829" "1.008" "0.932" "0.571" "1079.7" "1026.6" "1135.9" "992.6" "959.4" "1042.6" "895.6" "1088.3" "1005.9" "616.7" "" "" "" "" "" "" "" "" "" "" "571.7" "569.2" "650.5" "457.1" "519.1" "579.9" "527.1" "594.1" "564.3" "616.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5921429182500705176" "False" "High" "IsMasterProtein" "O43765" "Small glutamine-rich tetratricopeptide repeat-containing protein alpha OS=Homo sapiens OX=9606 GN=SGTA PE=1 SV=1" "0.000" "False" "15.923" "14" "4" "7" "4" "313" "34.0" "4.87" "17.25" "4" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00515, Pf13181, Pf16546" "6449" "ENSG00000104969" "SGTA" "D6W610; hsa:6449; O43765; Q6FIA9; Q9BTZ9" "" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "1" "0" "1.037" "0.995" "0.959" "0.968" "0.992" "0.980" "1.006" "1.241" "1.588" "368.1" "381.7" "366.2" "353.2" "356.3" "365.2" "360.8" "370.2" "456.7" "584.4" "" "" "" "" "" "" "" "" "" "" "194.9" "211.7" "209.7" "162.7" "192.8" "203.1" "212.4" "202.1" "256.2" "584.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4844902181037291409" "False" "High" "IsMasterProtein" "P62314" "Small nuclear ribonucleoprotein Sm D1 OS=Homo sapiens OX=9606 GN=SNRPD1 PE=1 SV=1" "0.000" "False" "15.908" "11" "2" "6" "2" "119" "13.3" "11.56" "31.36" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf01423" "6632" "ENSG00000167088" "SNRPD1" "B5BTZ1; hsa:6632; P13641; P62314" "mRNA processing" "mRNA Splicing - Major Pathway; snRNP Assembly; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway" "5" "0" "1.115" "1.079" "1.289" "1.109" "1.117" "1.257" "1.168" "1.240" "0.775" "715.0" "796.9" "771.6" "921.5" "793.1" "798.6" "898.7" "835.0" "886.8" "553.9" "" "" "" "" "" "" "" "" "" "" "378.6" "441.8" "441.9" "424.4" "429.1" "444.2" "528.9" "455.8" "497.5" "553.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7815504497160521648" "False" "High" "IsMasterProtein" "Q01826" "DNA-binding protein SATB1 OS=Homo sapiens OX=9606 GN=SATB1 PE=1 SV=1" "0.000" "False" "15.906" "8" "7" "9" "7" "763" "85.9" "6.54" "18.57" "7" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf02376, Pf16534, Pf16557" "6304" "ENSG00000182568" "SATB1" "B3KXF1; C9JTR6; hsa:6304; Q01826; Q59EQ0" "Vitamin D receptor pathway" "SUMOylation of chromatin organization proteins; Apoptotic cleavage of cellular proteins" "3" "0" "1.025" "1.055" "1.255" "1.186" "1.166" "1.867" "1.814" "1.967" "3.764" "656.6" "672.9" "692.4" "823.8" "778.9" "765.8" "1226.0" "1191.1" "1291.5" "2471.6" "" "" "" "" "" "" "" "" "" "" "347.7" "373.1" "396.6" "379.4" "421.4" "425.9" "721.5" "650.2" "724.5" "2471.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-163153293796965969" "False" "High" "IsMasterProtein" "Q9NWB6" "Arginine and glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=ARGLU1 PE=1 SV=1" "0.000" "False" "15.889" "19" "7" "8" "7" "273" "33.2" "10.35" "22.17" "7" "" "cytosol;mitochondrion;nucleus" "" "Pf15346" "55082" "ENSG00000134884" "ARGLU1" "B4E0Y3; hsa:55082; Q5T257; Q6IQ34; Q9NWB6" "" "" "0" "0" "1.078" "1.028" "1.037" "1.005" "0.928" "1.033" "1.011" "1.066" "0.794" "880.2" "949.1" "905.0" "912.7" "885.0" "816.9" "909.6" "889.4" "938.3" "699.0" "" "" "" "" "" "" "" "" "" "" "466.0" "526.2" "518.3" "420.3" "478.8" "454.4" "535.3" "485.5" "526.4" "699.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "837370257864581378" "False" "High" "IsMasterProtein" "Q01415" "N-acetylgalactosamine kinase OS=Homo sapiens OX=9606 GN=GALK2 PE=1 SV=1" "0.000" "False" "15.889" "9" "5" "6" "5" "458" "50.3" "6.61" "13.97" "5" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf00288, Pf08544, Pf10509" "2585" "ENSG00000156958" "GALK2" "hsa:2585; Q01415; Q7Z4Q4" "" "" "0" "0" "1.019" "1.011" "1.030" "1.051" "1.051" "1.068" "0.958" "1.014" "0.645" "591.4" "602.7" "597.7" "608.9" "621.4" "621.6" "631.6" "566.4" "599.5" "381.7" "" "" "" "" "" "" "" "" "" "" "313.1" "334.1" "342.3" "280.4" "336.2" "345.7" "371.7" "309.2" "336.3" "381.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1038572201038202760" "False" "High" "IsMasterProtein" "P05114" "Non-histone chromosomal protein HMG-14 OS=Homo sapiens OX=9606 GN=HMGN1 PE=1 SV=3" "0.000" "False" "15.881" "40" "4" "11" "4" "100" "10.7" "9.60" "33.34" "4" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "3150" "ENSG00000205581" "HMGN1" "hsa:3150; P05114; Q3KQR8" "ATM signaling in development and disease ; p38 MAPK signaling pathway; Pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "8" "0" "0.937" "1.024" "0.947" "0.979" "0.881" "0.993" "0.932" "0.954" "0.447" "996.4" "933.8" "1020.2" "943.2" "975.5" "878.3" "989.6" "928.1" "950.3" "445.6" "" "" "" "" "" "" "" "" "" "" "527.6" "517.7" "584.2" "434.4" "527.8" "488.5" "582.4" "506.6" "533.1" "445.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8109670193418590883" "False" "High" "IsMasterProtein" "O14641" "Segment polarity protein dishevelled homolog DVL-2 OS=Homo sapiens OX=9606 GN=DVL2 PE=1 SV=1" "0.000" "False" "15.876" "6" "4" "5" "3" "736" "78.9" "6.02" "13.62" "4" "cell-cell signaling;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00595, Pf00610, Pf00778, Pf02377, Pf12316" "1856" "ENSG00000004975" "DVL2" "D3DTN3; hsa:1856; O14641; Q53XM0" "Alzheimer's disease and miRNA effects; Neural crest differentiation; Notch signaling; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Type 2 papillary renal cell carcinoma; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)" "Asymmetric localization of PCP proteins; Degradation of DVL; RHO GTPases Activate Formins; Cargo recognition for clathrin-mediated endocytosis; WNT mediated activation of DVL; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by DVL-interacting proteins; WNT5:FZD7-mediated leishmania damping; Signaling by Hippo; WNT5A-dependent internalization of FZD4" "29" "0" "0.978" "1.205" "1.219" "1.172" "1.261" "2.101" "1.751" "1.943" "6.784" "126.7" "123.9" "152.7" "154.5" "148.5" "159.8" "266.3" "221.9" "246.2" "859.8" "" "" "" "" "" "" "" "" "" "" "67.1" "68.7" "87.4" "71.2" "80.4" "88.9" "156.7" "121.1" "138.1" "859.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7407446589588264140" "False" "High" "IsMasterProtein" "O94763" "Unconventional prefoldin RPB5 interactor 1 OS=Homo sapiens OX=9606 GN=URI1 PE=1 SV=3" "0.000" "False" "15.870" "14" "6" "6" "6" "535" "59.8" "5.05" "15.40" "6" "other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02996" "8725" "ENSG00000105176" "URI1" "A8K805; H7BY42; hsa:8725; O94763; Q8TC23; Q9UNU3" "" "" "0" "0" "0.862" "1.046" "1.012" "0.954" "0.892" "1.095" "1.132" "1.043" "0.828" "272.4" "234.8" "285.0" "275.7" "259.7" "243.0" "298.1" "308.4" "284.0" "225.5" "" "" "" "" "" "" "" "" "" "" "144.2" "130.2" "163.2" "127.0" "140.5" "135.1" "175.5" "168.4" "159.3" "225.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-630716066930521994" "False" "High" "IsMasterProtein" "P55957" "BH3-interacting domain death agonist OS=Homo sapiens OX=9606 GN=BID PE=1 SV=1" "0.000" "False" "15.861" "17" "3" "8" "3" "195" "22.0" "5.44" "22.44" "3" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf06393" "637" "ENSG00000015475" "BID" "hsa:637; P55957; Q549M7; Q71T04; Q7Z4M9; Q8IY86" "miRNA regulation of DNA damage response; TP53 network; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced HIF-1 survival signaling; Apoptosis modulation by HSP70; Regulation of apoptosis by parathyroid hormone-related protein; miRNA regulation of p53 pathway in prostate cancer; Non-small cell lung cancer; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; Unfolded protein response; Complement system in neuronal development and plasticity; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; DNA damage response" "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; Activation, myristolyation of BID and translocation to mitochondria; Activation of BAD and translocation to mitochondria ; Activation and oligomerization of BAK protein; Activation, translocation and oligomerization of BAX" "30" "0" "1.155" "1.163" "1.077" "0.991" "0.952" "0.845" "1.026" "0.990" "0.624" "279.1" "322.3" "324.7" "300.5" "276.5" "265.6" "235.9" "286.3" "276.3" "174.1" "" "" "" "" "" "" "" "" "" "" "147.8" "178.7" "186.0" "138.4" "149.6" "147.7" "138.8" "156.3" "155.0" "174.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1214418954468839603" "False" "High" "IsMasterProtein" "Q96C01" "Protein FAM136A OS=Homo sapiens OX=9606 GN=FAM136A PE=1 SV=1" "0.000" "False" "15.857" "29" "4" "6" "4" "138" "15.6" "7.61" "17.45" "4" "" "other cell component" "" "Pf05811" "84908" "ENSG00000035141" "FAM136A" "hsa:84908; Q96C01; Q96SS3" "" "" "0" "0" "0.945" "1.024" "0.822" "0.875" "0.835" "0.772" "0.786" "0.904" "0.914" "489.4" "462.6" "501.1" "402.5" "428.3" "408.5" "377.7" "384.6" "442.4" "447.2" "" "" "" "" "" "" "" "" "" "" "259.1" "256.5" "287.0" "185.4" "231.7" "227.2" "222.3" "209.9" "248.2" "447.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8339310688111388996" "False" "High" "IsMasterProtein" "Q9HCE5" "N6-adenosine-methyltransferase non-catalytic subunit OS=Homo sapiens OX=9606 GN=METTL14 PE=1 SV=2" "0.000" "False" "15.831" "8" "4" "4" "4" "456" "52.1" "6.21" "12.03" "4" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05063" "57721" "ENSG00000145388" "METTL14" "A6NIG1; hsa:57721; Q969V2; Q9HCE5" "1p36 copy number variation syndrome" "Processing of Capped Intron-Containing Pre-mRNA" "2" "0" "0.973" "0.884" "1.121" "1.047" "0.961" "1.154" "0.956" "0.939" "0.682" "261.3" "254.3" "231.1" "292.9" "273.6" "251.1" "301.6" "249.8" "245.4" "178.1" "" "" "" "" "" "" "" "" "" "" "138.4" "141.0" "132.3" "134.9" "148.0" "139.7" "177.5" "136.4" "137.6" "178.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "614531152509290275" "False" "High" "IsMasterProtein" "Q9BRD0" "BUD13 homolog OS=Homo sapiens OX=9606 GN=BUD13 PE=1 SV=1" "0.000" "False" "15.826" "5" "3" "4" "3" "619" "70.5" "9.86" "11.59" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf09736" "84811" "ENSG00000137656" "BUD13" "A8K0S0; hsa:84811; Q96LS7; Q9BRD0" "" "mRNA Splicing - Major Pathway" "1" "0" "0.935" "0.939" "1.119" "1.092" "1.029" "1.289" "1.320" "1.294" "0.793" "262.3" "245.3" "246.4" "293.5" "286.5" "269.8" "338.0" "346.2" "339.4" "208.1" "" "" "" "" "" "" "" "" "" "" "138.9" "136.0" "141.1" "135.2" "155.0" "150.1" "198.9" "189.0" "190.4" "208.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "568464796837822948" "False" "High" "IsMasterProtein" "O43823" "A-kinase anchor protein 8 OS=Homo sapiens OX=9606 GN=AKAP8 PE=1 SV=1" "0.000" "False" "15.821" "4" "3" "4" "3" "692" "76.1" "5.15" "13.29" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04988" "10270" "ENSG00000105127" "AKAP8" "hsa:10270; O43823" "G protein signaling pathways" "" "1" "0" "0.877" "0.869" "1.154" "0.901" "1.019" "1.402" "1.145" "1.124" "2.697" "147.2" "129.1" "128.0" "169.8" "132.6" "150.0" "206.4" "168.6" "165.5" "397.1" "" "" "" "" "" "" "" "" "" "" "78.0" "71.6" "73.3" "78.2" "71.8" "83.5" "121.5" "92.0" "92.9" "397.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8361684917289872737" "False" "High" "IsMasterProtein" "Q9BSW2" "EF-hand calcium-binding domain-containing protein 4B OS=Homo sapiens OX=9606 GN=CRACR2A PE=1 SV=2" "0.000" "False" "15.799" "9" "7" "7" "7" "731" "83.1" "5.24" "17.39" "7" "transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00071, Pf13499" "84766" "ENSG00000130038" "CRACR2A" "B4E1X0; B9EK63; hsa:84766; Q9BSW2" "Vitamin D receptor pathway" "Neutrophil degranulation" "2" "0" "1.119" "1.141" "1.247" "1.223" "1.117" "1.340" "1.292" "1.176" "1.061" "183.6" "205.5" "209.4" "229.0" "224.5" "205.1" "246.1" "237.3" "215.9" "194.8" "" "" "" "" "" "" "" "" "" "" "97.2" "113.9" "119.9" "105.5" "121.5" "114.1" "144.9" "129.5" "121.1" "194.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4971008711368622204" "False" "High" "IsMasterProtein" "Q9BVW5" "TIMELESS-interacting protein OS=Homo sapiens OX=9606 GN=TIPIN PE=1 SV=2" "0.000" "False" "15.796" "13" "4" "5" "4" "301" "34.5" "4.82" "16.09" "4" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf07962" "54962" "ENSG00000075131" "TIPIN" "B2CW64; hsa:54962; Q9BVW5; Q9NWZ6" "" "Processing of DNA double-strand break ends" "1" "0" "1.127" "1.163" "1.063" "1.063" "1.150" "1.127" "1.265" "1.335" "1.875" "419.6" "472.8" "488.1" "446.3" "446.2" "482.5" "473.1" "530.8" "560.4" "786.9" "" "" "" "" "" "" "" "" "" "" "222.2" "262.1" "279.5" "205.5" "241.4" "268.4" "278.4" "289.7" "314.4" "786.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2901873737565675382" "False" "High" "IsMasterProtein" "O95825" "Quinone oxidoreductase-like protein 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=2" "0.000" "False" "15.772" "9" "3" "5" "3" "349" "38.7" "5.78" "9.62" "3" "other metabolic processes" "" "other molecular function" "" "9946" "ENSG00000205758" "CRYZL1" "B2RDX1; B3KQ77; hsa:9946; O95825; Q96DY0; Q9NVY7" "" "" "0" "0" "1.045" "1.064" "1.145" "1.216" "1.128" "1.230" "1.204" "1.050" "0.592" "171.2" "179.0" "182.3" "196.0" "208.2" "193.2" "210.6" "206.1" "179.8" "101.3" "" "" "" "" "" "" "" "" "" "" "90.7" "99.2" "104.4" "90.3" "112.6" "107.5" "124.0" "112.5" "100.9" "101.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "152076562272560972" "False" "High" "IsMasterProtein" "Q13409" "Cytoplasmic dynein 1 intermediate chain 2 OS=Homo sapiens OX=9606 GN=DYNC1I2 PE=1 SV=3" "0.000" "False" "15.757" "8" "5" "9" "5" "638" "71.4" "5.20" "18.67" "5" "transport;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf11540" "1781" "ENSG00000077380; ENSG00000292102" "DYNC1I2" "B7ZA04; D3DPD4; D3DPD5; D3DPD6; hsa:1781; Q13409; Q32LY9; Q53S84; Q5BJF8; Q7Z4X1; Q96NG7; Q96S87; Q9BXZ5; Q9NT58" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption; HDAC6 interactions in the central nervous system" "HCMV Early Events; Separation of Sister Chromatids; Aggrephagy; Regulation of PLK1 Activity at G2/M Transition; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "23" "0" "1.031" "0.992" "1.027" "1.062" "0.976" "0.907" "0.946" "0.895" "0.695" "702.7" "724.7" "697.4" "721.9" "746.5" "685.9" "637.5" "664.5" "628.7" "488.2" "" "" "" "" "" "" "" "" "" "" "372.1" "401.8" "399.4" "332.4" "403.9" "381.5" "375.2" "362.7" "352.7" "488.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4686891910023409545" "False" "High" "IsMasterProtein" "P62140" "Serine/threonine-protein phosphatase PP1-beta catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CB PE=1 SV=3" "0.000" "False" "15.755" "13" "4" "7" "2" "327" "37.2" "6.19" "16.46" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00149, Pf16891" "5500" "ENSG00000213639" "PPP1CB" "B2R5V4; D6W565; hsa:5500; P37140; P62140; Q5U087; Q6FG45" "Common pathways underlying drug addiction; Focal adhesion; Hippo-Merlin signaling dysregulation; 22q11.2 copy number variation syndrome; Airway smooth muscle cell contraction; Neuroinflammation and glutamatergic signaling; G13 signaling pathway" "RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; Triglyceride catabolism; Regulation of PLK1 Activity at G2/M Transition; Circadian Clock; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; RHO GTPases activate PAKs; Downregulation of TGF-beta receptor signaling; Maturation of hRSV A proteins" "19" "0" "0.950" "0.976" "1.017" "0.995" "1.012" "1.109" "0.980" "1.050" "0.915" "330.3" "313.6" "322.2" "336.0" "328.7" "334.4" "366.3" "323.7" "346.7" "302.3" "" "" "" "" "" "" "" "" "" "" "174.9" "173.9" "184.5" "154.7" "177.9" "186.0" "215.6" "176.7" "194.5" "302.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2928934229844812076" "False" "High" "IsMasterProtein" "Q8TCD5" "5'(3')-deoxyribonucleotidase, cytosolic type OS=Homo sapiens OX=9606 GN=NT5C PE=1 SV=2" "0.000" "False" "15.753" "21" "5" "5" "5" "201" "23.4" "6.64" "14.64" "5" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06941" "30833" "ENSG00000125458" "NT5C" "hsa:30833; Q8TCD5; Q96HS6; Q9NP82" "Pyrimidine metabolism" "Purine catabolism; Pyrimidine catabolism" "3" "0" "0.918" "1.175" "1.160" "1.023" "1.036" "1.032" "0.910" "0.879" "0.536" "378.2" "347.3" "444.5" "438.5" "386.8" "391.8" "390.4" "344.1" "332.6" "202.9" "" "" "" "" "" "" "" "" "" "" "200.2" "192.6" "254.6" "201.9" "209.3" "217.9" "229.8" "187.8" "186.6" "202.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1837878793854205649" "False" "High" "IsMasterProtein" "Q9BVL2" "Nucleoporin p58/p45 OS=Homo sapiens OX=9606 GN=NUP58 PE=1 SV=1" "0.000" "False" "15.733" "8" "5" "5" "5" "599" "60.9" "9.33" "16.36" "5" "transport;other biological processes" "other membranes;nucleus" "other molecular function" "Pf15967" "9818" "ENSG00000139496" "NUP58" "A6NI12; B4DZJ1; hsa:9818; O43160; Q5JRG2; Q5JRG5; Q9BVL2" "" "" "0" "0" "1.079" "1.080" "1.035" "1.091" "1.102" "1.104" "1.134" "1.126" "1.018" "479.2" "517.1" "517.7" "496.0" "523.0" "528.1" "528.9" "543.4" "539.7" "487.6" "" "" "" "" "" "" "" "" "" "" "253.7" "286.7" "296.5" "228.4" "283.0" "293.8" "311.2" "296.6" "302.8" "487.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "784332711560809760" "False" "High" "IsMasterProtein" "P62072" "Mitochondrial import inner membrane translocase subunit Tim10 OS=Homo sapiens OX=9606 GN=TIMM10 PE=1 SV=1" "0.000" "False" "15.723" "53" "5" "7" "5" "90" "10.3" "6.29" "19.47" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf02953" "26519" "ENSG00000134809" "TIMM10" "A8K136; hsa:26519; P62072; Q9WV99; Q9WVA0; Q9Y5J8" "" "Mitochondrial protein degradation; Mitochondrial protein import" "2" "0" "0.963" "1.132" "1.269" "0.794" "0.889" "0.903" "1.068" "0.842" "0.510" "339.1" "326.4" "383.9" "430.3" "269.1" "301.6" "306.4" "362.4" "285.5" "172.8" "" "" "" "" "" "" "" "" "" "" "179.6" "181.0" "219.9" "198.2" "145.6" "167.8" "180.3" "197.8" "160.2" "172.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4697370261215889932" "False" "High" "IsMasterProtein" "O43583" "Density-regulated protein OS=Homo sapiens OX=9606 GN=DENR PE=1 SV=2" "0.000" "False" "15.714" "17" "3" "6" "3" "198" "22.1" "5.30" "18.11" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "" "nucleic acid binding activity" "Pf01253, Pf21023" "8562" "ENSG00000139726" "DENR" "hsa:8562; O43583; Q9H3U6; Q9UKZ0" "" "" "0" "0" "1.020" "1.050" "1.022" "1.016" "1.072" "1.053" "0.966" "0.966" "0.641" "169.0" "172.4" "177.4" "172.7" "171.7" "181.1" "177.9" "163.3" "163.1" "108.3" "" "" "" "" "" "" "" "" "" "" "89.5" "95.6" "101.6" "79.6" "92.9" "100.7" "104.7" "89.1" "91.5" "108.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3853404113387134869" "False" "High" "IsMasterProtein" "Q9UK59" "Lariat debranching enzyme OS=Homo sapiens OX=9606 GN=DBR1 PE=1 SV=2" "0.000" "False" "15.682" "8" "4" "5" "4" "544" "61.5" "5.47" "11.60" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00149, Pf05011" "51163" "ENSG00000138231" "DBR1" "hsa:51163; Q96GH0; Q9NXQ6; Q9UK59" "" "" "0" "0" "1.068" "1.026" "1.065" "1.052" "1.087" "0.964" "1.008" "0.957" "0.726" "133.7" "142.8" "137.1" "142.4" "140.7" "145.3" "128.8" "134.7" "127.9" "97.0" "" "" "" "" "" "" "" "" "" "" "70.8" "79.2" "78.5" "65.6" "76.1" "80.8" "75.8" "73.5" "71.8" "97.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2934429115890705699" "False" "High" "IsMasterProtein" "P49821" "NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFV1 PE=1 SV=4" "0.000" "False" "15.678" "10" "5" "6" "5" "464" "50.8" "8.21" "10.67" "5" "other metabolic processes;transport" "other membranes;cytosol;mitochondrion" "transporter activity;other molecular function" "Pf01512, Pf10589" "4723" "ENSG00000167792" "NDUFV1" "hsa:4723; O60924; O60940; P49821; Q16104; Q6IBR3; Q96BF8; Q96HS7" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; HDAC6 interactions in the central nervous system; Oxidative phosphorylation" "Mitochondrial protein degradation; Complex I biogenesis" "7" "0" "1.057" "0.764" "0.887" "1.028" "0.960" "0.867" "0.938" "0.799" "0.433" "71.2" "75.3" "54.4" "63.2" "73.2" "68.4" "61.8" "66.8" "56.9" "30.9" "" "" "" "" "" "" "" "" "" "" "37.7" "41.7" "31.1" "29.1" "39.6" "38.0" "36.4" "36.5" "31.9" "30.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1208867046530031718" "False" "High" "IsMasterProtein" "P47813" "Eukaryotic translation initiation factor 1A, X-chromosomal OS=Homo sapiens OX=9606 GN=EIF1AX PE=1 SV=2" "0.000" "False" "15.662" "28" "5" "7" "5" "144" "16.5" "5.24" "18.19" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf01176" "1964" "ENSG00000173674" "EIF1AX" "B2R5U5; hsa:1964; P47813; Q0VGC2; Q5JPS5; Q5JPS6" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition" "8" "0" "1.039" "1.161" "1.248" "0.797" "0.843" "0.833" "1.184" "0.861" "0.581" "1136.7" "1180.5" "1319.2" "1419.0" "905.5" "958.6" "946.7" "1345.7" "978.8" "660.8" "" "" "" "" "" "" "" "" "" "" "601.9" "654.5" "755.5" "653.5" "489.9" "533.2" "557.2" "734.6" "549.1" "660.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3944775931209301438" "False" "High" "IsMasterProtein" "P60660" "Myosin light polypeptide 6 OS=Homo sapiens OX=9606 GN=MYL6 PE=1 SV=2" "0.000" "False" "15.653" "30" "4" "6" "3" "151" "16.9" "4.65" "17.06" "4" "other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "" "4637" "ENSG00000092841" "MYL6" "hsa:4637; P16475; P24572; P24573; P60660; Q12790; Q561V9; Q6IAZ0; Q6IPY5" "Ciliary landscape" "RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "8" "0" "0.950" "1.017" "0.943" "0.982" "0.928" "0.966" "0.921" "0.896" "0.776" "487.1" "462.6" "495.4" "459.3" "478.1" "452.1" "470.7" "448.8" "436.5" "378.1" "" "" "" "" "" "" "" "" "" "" "257.9" "256.5" "283.7" "211.5" "258.6" "251.5" "277.0" "245.0" "244.9" "378.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4257366520332167042" "False" "High" "IsMasterProtein" "Q13422" "DNA-binding protein Ikaros OS=Homo sapiens OX=9606 GN=IKZF1 PE=1 SV=1" "0.000" "False" "15.645" "12" "6" "9" "6" "519" "57.5" "6.58" "21.40" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "10320" "ENSG00000185811" "IKZF1" "A4D260; B4E0Z1; D3DVM5; hsa:10320; O00598; Q13422; Q53XL2; Q69BM4; Q8WVA3" "Hematopoietic stem cell differentiation; Development of pulmonary dendritic cells and macrophage subsets" "" "2" "0" "1.047" "1.041" "1.493" "1.204" "1.110" "1.260" "1.267" "1.098" "0.894" "317.9" "332.7" "330.9" "474.5" "382.6" "352.7" "400.4" "402.6" "348.9" "284.2" "" "" "" "" "" "" "" "" "" "" "168.3" "184.5" "189.5" "218.5" "207.0" "196.2" "235.6" "219.8" "195.7" "284.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8133999276561542569" "False" "High" "IsMasterProtein" "Q86X55" "Histone-arginine methyltransferase CARM1 OS=Homo sapiens OX=9606 GN=CARM1 PE=1 SV=3" "0.000" "False" "15.626" "7" "5" "8" "5" "608" "65.8" "6.73" "20.76" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06325, Pf11531" "10498" "ENSG00000142453" "CARM1" "A6NN38; hsa:10498; Q86X55" "Androgen receptor signaling pathway; Nitric oxide metabolism in cystic fibrosis" "Estrogen-dependent gene expression; Heme signaling; Transcriptional activation of mitochondrial biogenesis; RMTs methylate histone arginines; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; RORA activates gene expression" "15" "0" "0.971" "0.930" "0.927" "0.937" "0.991" "0.964" "1.031" "0.988" "0.506" "1038.6" "1009.0" "966.1" "962.4" "973.1" "1029.2" "1001.5" "1070.8" "1026.4" "525.3" "" "" "" "" "" "" "" "" "" "" "549.9" "559.4" "553.3" "443.2" "526.5" "572.5" "589.4" "584.5" "575.8" "525.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1607467674154274672" "False" "High" "IsMasterProtein" "Q8N4Q1" "Mitochondrial intermembrane space import and assembly protein 40 OS=Homo sapiens OX=9606 GN=CHCHD4 PE=1 SV=1" "0.000" "False" "15.618" "13" "1" "2" "1" "142" "16.0" "4.31" "10.35" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "mitochondrion" "other molecular function" "Pf06747" "131474" "ENSG00000163528" "CHCHD4" "A8K3Z9; hsa:131474; Q8N4Q1; Q96AI2; Q96MY6" "" "Mitochondrial protein import" "1" "0" "0.936" "1.052" "0.902" "0.979" "1.003" "0.873" "0.916" "0.920" "0.556" "570.9" "534.6" "600.8" "514.8" "559.0" "572.9" "498.1" "523.0" "525.1" "317.2" "" "" "" "" "" "" "" "" "" "" "302.3" "296.4" "344.1" "237.1" "302.5" "318.7" "293.2" "285.5" "294.5" "317.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8135385361793162553" "False" "High" "IsMasterProtein" "Q9BQA1" "Methylosome protein WDR77 OS=Homo sapiens OX=9606 GN=WDR77 PE=1 SV=1" "0.000" "False" "15.591" "8" "2" "5" "2" "342" "36.7" "5.17" "15.03" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400" "79084" "ENSG00000116455" "WDR77" "B3KMW6; B4DP38; hsa:79084; Q3LID2; Q53FU2; Q6JZZ5; Q96GK4; Q9BQA1; Q9BWY3" "" "RMTs methylate histone arginines; snRNP Assembly" "2" "0" "1.109" "1.120" "1.223" "1.095" "1.214" "1.239" "1.119" "1.018" "0.768" "101.7" "112.8" "114.0" "124.4" "111.4" "123.5" "126.0" "113.8" "103.6" "78.1" "" "" "" "" "" "" "" "" "" "" "53.9" "62.5" "65.3" "57.3" "60.3" "68.7" "74.2" "62.1" "58.1" "78.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5309458315612800198" "False" "High" "IsMasterProtein" "O00178" "GTP-binding protein 1 OS=Homo sapiens OX=9606 GN=GTPBP1 PE=1 SV=3" "0.000" "False" "15.562" "10" "5" "5" "5" "669" "72.4" "8.34" "13.65" "5" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03144" "9567" "ENSG00000100226" "GTPBP1" "hsa:9567; O00178; Q6IC67" "" "" "0" "0" "1.131" "1.099" "1.283" "0.979" "0.987" "0.989" "0.949" "0.929" "0.983" "190.9" "215.9" "209.8" "245.0" "186.8" "188.5" "188.8" "181.2" "177.3" "187.7" "" "" "" "" "" "" "" "" "" "" "101.1" "119.7" "120.1" "112.8" "101.1" "104.8" "111.1" "98.9" "99.5" "187.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6789229082663828317" "False" "High" "IsMasterProtein" "Q6ZUJ8" "Phosphoinositide 3-kinase adapter protein 1 OS=Homo sapiens OX=9606 GN=PIK3AP1 PE=1 SV=2" "0.000" "False" "15.561" "5" "3" "4" "3" "805" "90.3" "5.40" "6.88" "3" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "signal transduction activity or receptor binding;other molecular function" "Pf14545, Pf18567" "118788" "ENSG00000155629" "PIK3AP1" "hsa:118788; Q5TB56; Q5VXJ9; Q6ZUJ8; Q8N6J6; Q8NAC8" "B cell receptor signaling pathway; PI3K-Akt signaling pathway" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer" "6" "0" "1.127" "1.091" "1.050" "1.119" "0.940" "1.158" "0.834" "1.039" "4.274" "53.4" "60.2" "58.2" "56.0" "59.8" "50.2" "61.8" "44.5" "55.4" "228.2" "" "" "" "" "" "" "" "" "" "" "28.3" "33.4" "33.4" "25.8" "32.3" "27.9" "36.4" "24.3" "31.1" "228.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6364343737777032179" "False" "High" "IsMasterProtein" "P08754" "Guanine nucleotide-binding protein G(i) subunit alpha-3 OS=Homo sapiens OX=9606 GN=GNAI3 PE=1 SV=3" "0.000" "False" "15.554" "10" "3" "4" "2" "354" "40.5" "5.69" "12.12" "3" "cell cycle OR cell proliferation;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00503" "2773" "ENSG00000065135" "GNAI3" "hsa:2773; P08754; P17539; Q5TZX1" "Thyroid stimulating hormone (TSH) signaling pathway; S1P receptor signal transduction; Complement system; G protein signaling pathways; Chemokine signaling pathway; Hippo signaling regulation pathways; Purinergic signaling; Calcium regulation in cardiac cells; 5q35 copy number variation; Serotonin HTR1 group and FOS pathway" "G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production" "18" "0" "1.103" "1.169" "1.222" "1.102" "1.071" "1.178" "1.094" "0.925" "0.763" "258.9" "285.6" "302.7" "316.3" "285.3" "277.2" "304.9" "283.1" "239.4" "197.5" "" "" "" "" "" "" "" "" "" "" "137.1" "158.4" "173.4" "145.7" "154.4" "154.2" "179.4" "154.6" "134.3" "197.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4570551838394526128" "False" "High" "IsMasterProtein" "Q86VN1" "Vacuolar protein-sorting-associated protein 36 OS=Homo sapiens OX=9606 GN=VPS36 PE=1 SV=1" "0.000" "False" "15.533" "11" "5" "5" "5" "386" "43.8" "7.20" "14.38" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf04157, Pf11605" "51028" "ENSG00000136100" "VPS36" "A8K125; hsa:51028; Q3ZCV7; Q5H9S1; Q5VXB6; Q86VN1; Q9H8Z5; Q9Y3E3" "Network map of SARS-CoV-2 signaling pathway" "Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events" "3" "0" "1.008" "0.983" "1.001" "1.067" "0.983" "1.011" "1.053" "0.811" "1.022" "429.5" "432.7" "422.2" "429.8" "458.3" "422.1" "434.2" "452.1" "348.2" "438.8" "" "" "" "" "" "" "" "" "" "" "227.4" "239.9" "241.8" "197.9" "248.0" "234.8" "255.5" "246.8" "195.3" "438.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7181464862980127615" "False" "High" "IsMasterProtein" "Q13630" "GDP-L-fucose synthase OS=Homo sapiens OX=9606 GN=GFUS PE=1 SV=1" "0.000" "False" "15.530" "13" "3" "3" "3" "321" "35.9" "6.60" "12.97" "3" "cell adhesion;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf01370" "7264" "ENSG00000104522; ENSG00000278243" "GFUS" "B2R8Y7; D3DWK5; hsa:7264; Q13630; Q567Q9; Q9UDG7" "" "GDP-fucose biosynthesis" "1" "0" "1.169" "1.016" "0.999" "1.154" "1.274" "1.078" "1.114" "1.036" "0.952" "82.7" "96.7" "84.0" "82.6" "95.5" "105.4" "89.1" "92.1" "85.7" "78.7" "" "" "" "" "" "" "" "" "" "" "43.8" "53.6" "48.1" "38.0" "51.6" "58.6" "52.4" "50.3" "48.1" "78.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8751597953454221886" "False" "High" "IsMasterProtein" "P09496" "Clathrin light chain A OS=Homo sapiens OX=9606 GN=CLTA PE=1 SV=1" "0.000" "False" "15.526" "16" "5" "10" "5" "248" "27.1" "4.51" "32.78" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01086" "1211" "ENSG00000122705" "CLTA" "A8K4W3; B4DIN1; F5H6N3; hsa:1211; P09496; Q2XPN5; Q53XZ1" "Synaptic vesicle pathway; Ebola virus infection in host; Fragile X syndrome" "Recycling pathway of L1; MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; Entry of Influenza Virion into Host Cell via Endocytosis; Formation of annular gap junctions" "17" "0" "0.920" "0.970" "0.875" "0.950" "0.868" "0.911" "0.890" "0.858" "0.494" "745.8" "685.8" "723.1" "652.3" "708.3" "647.0" "679.1" "663.5" "639.9" "368.2" "" "" "" "" "" "" "" "" "" "" "394.9" "380.2" "414.1" "300.4" "383.2" "359.9" "399.7" "362.2" "358.9" "368.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9010932242184779008" "False" "High" "IsMasterProtein" "P10644" "cAMP-dependent protein kinase type I-alpha regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR1A PE=1 SV=1" "0.000" "False" "15.525" "11" "4" "6" "2" "381" "43.0" "5.35" "17.64" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf02197" "5573" "ENSG00000108946" "PRKAR1A" "hsa:5573; K7ER48; P10644; Q567S7" "Mesodermal commitment pathway; Myometrial relaxation and contraction pathways; Mesodermal commitment pathway; G protein signaling pathways; Cannabinoid receptor signaling; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Cardiomyocyte signaling pathways converging on titin; Calcium regulation in cardiac cells; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; FCGR3A-mediated IL10 synthesis; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Hedgehog 'off' state; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase" "27" "2" "1.061" "1.025" "1.141" "1.242" "1.171" "1.207" "1.005" "1.200" "2.156" "483.2" "512.7" "495.3" "551.2" "600.2" "565.7" "583.1" "485.5" "580.1" "1041.7" "" "" "" "" "" "" "" "" "" "" "255.9" "284.2" "283.7" "253.8" "324.7" "314.7" "343.2" "265.0" "325.4" "1041.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9082551203190853772" "False" "High" "IsMasterProtein" "Q16777" "Histone H2A type 2-C OS=Homo sapiens OX=9606 GN=H2AC20 PE=1 SV=4" "0.000" "False" "15.510" "33" "4" "9" "2" "129" "14.0" "10.90" "22.04" "4" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125, Pf16211" "8338" "ENSG00000184260" "H2AC20" "hsa:8338; Q16777; Q6DRA7; Q8IUE5" "" "UCH proteinases; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of the beta-catenin:TCF transactivating complex; RMTs methylate histone arginines; RNA Polymerase I Promoter Escape; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Amyloid fiber formation; Meiotic synapsis; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Oxidative Stress Induced Senescence; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Metalloprotease DUBs; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; Chromatin modifications during the maternal to zygotic transition (MZT); Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis" "42" "1" "1.026" "1.001" "1.427" "0.988" "1.103" "0.976" "0.848" "0.986" "1.644" "403.2" "413.5" "403.5" "575.3" "398.3" "444.7" "393.4" "342.0" "397.7" "663.0" "" "" "" "" "" "" "" "" "" "" "213.5" "229.3" "231.1" "264.9" "215.5" "247.4" "231.5" "186.7" "223.1" "663.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7722253779426460975" "False" "High" "IsMasterProtein" "O00571" "ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=3" "0.000" "False" "15.506" "7" "5" "6" "4" "662" "73.2" "7.18" "13.69" "5" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1654" "ENSG00000215301" "DDX3X" "A8K538; B4E3E8; hsa:1654; O00571; O15536" "Novel intracellular components of RIG-I-like receptor pathway; Hepatitis B infection" "Neutrophil degranulation" "3" "0" "0.958" "1.014" "1.382" "1.436" "1.200" "2.118" "2.080" "2.035" "2.938" "201.8" "193.3" "204.6" "278.8" "289.7" "242.2" "427.2" "419.6" "410.5" "592.9" "" "" "" "" "" "" "" "" "" "" "106.8" "107.2" "117.2" "128.4" "156.7" "134.7" "251.4" "229.1" "230.3" "592.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7310593134022698633" "False" "High" "IsMasterProtein" "P57081" "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 OS=Homo sapiens OX=9606 GN=WDR4 PE=1 SV=2" "0.000" "False" "15.504" "7" "3" "5" "3" "412" "45.5" "7.11" "12.15" "3" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf00400" "10785" "ENSG00000160193" "WDR4" "A8KA58; B2RCA3; B4DNQ7; D3DSK3; hsa:10785; P57081; Q9BVM5; Q9HCR3" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.049" "1.080" "0.999" "1.123" "1.123" "1.014" "1.083" "1.140" "0.696" "484.8" "508.6" "523.6" "484.2" "544.4" "544.4" "491.9" "525.2" "552.6" "337.7" "" "" "" "" "" "" "" "" "" "" "256.7" "282.0" "299.9" "223.0" "294.5" "302.8" "289.5" "286.7" "310.0" "337.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4204109305997435954" "False" "High" "IsMasterProtein" "Q07960" "Rho GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=ARHGAP1 PE=1 SV=1" "0.000" "False" "15.482" "8" "4" "4" "4" "439" "50.4" "6.29" "11.60" "4" "transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00620, Pf13716" "392" "ENSG00000175220" "ARHGAP1" "D3DQQ6; hsa:392; Q07960" "" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOC GTPase cycle; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle" "13" "0" "1.008" "0.934" "0.937" "1.019" "0.947" "1.016" "0.942" "0.966" "1.427" "569.2" "573.5" "531.4" "533.1" "579.9" "539.3" "578.3" "536.0" "549.7" "812.0" "" "" "" "" "" "" "" "" "" "" "301.4" "318.0" "304.3" "245.5" "313.7" "300.0" "340.3" "292.6" "308.4" "812.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8297311667808919408" "False" "High" "IsMasterProtein" "Q14651" "Plastin-1 OS=Homo sapiens OX=9606 GN=PLS1 PE=1 SV=2" "0.000" "False" "15.454" "5" "3" "5" "1" "629" "70.2" "5.41" "11.64" "3" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00036, Pf00307, Pf13405" "5357" "ENSG00000120756" "PLS1" "A8K2Q1; D3DNG3; hsa:5357; Q14651; Q8NEG6" "" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "2" "0" "1.161" "0.896" "1.309" "1.061" "0.968" "1.250" "0.921" "0.928" "0.997" "92.3" "107.1" "82.7" "120.9" "98.0" "89.3" "115.4" "85.0" "85.6" "92.0" "" "" "" "" "" "" "" "" "" "" "48.9" "59.4" "47.4" "55.7" "53.0" "49.7" "67.9" "46.4" "48.0" "92.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "769140260772308897" "False" "High" "IsMasterProtein" "P07910" "Heterogeneous nuclear ribonucleoproteins C1/C2 OS=Homo sapiens OX=9606 GN=HNRNPC PE=1 SV=4" "0.000" "False" "15.446" "12" "4" "4" "4" "306" "33.7" "5.08" "12.32" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "3183" "ENSG00000092199" "HNRNPC" "D3DS19; D3DS22; hsa:3183; P07910; P22628; Q53EX2; Q59FD3; Q5FWE8; Q86SF8; Q86U45; Q96HK7; Q96HM4; Q96IY5; Q9BTS3" "mRNA processing" "SUMOylation of RNA binding proteins; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "6" "0" "0.994" "1.103" "1.121" "0.999" "1.070" "0.934" "0.620" "1.061" "4.558" "445.5" "442.6" "491.3" "499.5" "445.3" "476.6" "416.3" "276.0" "472.7" "2030.5" "" "" "" "" "" "" "" "" "" "" "235.9" "245.4" "281.4" "230.0" "240.9" "265.1" "245.0" "150.7" "265.2" "2030.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-204711257539491149" "False" "High" "IsMasterProtein" "O96017" "Serine/threonine-protein kinase Chk2 OS=Homo sapiens OX=9606 GN=CHEK2 PE=1 SV=1" "0.000" "False" "15.416" "6" "4" "5" "4" "543" "60.9" "5.91" "16.39" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00498" "11200" "ENSG00000183765" "CHEK2" "A8K3Y9; B7ZBF3; B7ZBF4; B7ZBF5; hsa:11200; O96017; Q6QA03; Q6QA04; Q6QA05; Q6QA06; Q6QA07; Q6QA08; Q6QA10; Q6QA11; Q6QA12; Q6QA13; Q9HBS5; Q9HCQ8; Q9UGF0; Q9UGF1" "miRNA regulation of DNA damage response; Cell cycle; ATM signaling in development and disease ; miRNA regulation of p53 pathway in prostate cancer; DNA damage response" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Regulation of TP53 Activity through Methylation; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Stabilization of p53" "13" "0" "1.002" "0.885" "1.035" "1.040" "1.039" "1.172" "1.051" "1.111" "0.984" "1253.3" "1255.7" "1108.7" "1296.9" "1303.9" "1302.4" "1469.4" "1317.0" "1392.7" "1233.8" "" "" "" "" "" "" "" "" "" "" "663.6" "696.2" "635.0" "597.2" "705.5" "724.5" "864.8" "718.9" "781.3" "1233.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4925362542189153162" "False" "High" "IsMasterProtein" "Q92854" "Semaphorin-4D OS=Homo sapiens OX=9606 GN=SEMA4D PE=1 SV=1" "0.000" "False" "15.409" "5" "5" "5" "5" "862" "96.1" "7.96" "13.39" "5" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00047, Pf01403, Pf01437" "10507" "ENSG00000187764" "SEMA4D" "B2RPM6; hsa:10507; Q7Z5S4; Q8N8B0; Q92854" "Clock-controlled autophagy in bone metabolism" "Sema4D induced cell migration and growth-cone collapse; Other semaphorin interactions; Sema4D mediated inhibition of cell attachment and migration" "4" "0" "0.914" "0.956" "0.886" "0.952" "0.952" "0.842" "0.767" "0.858" "0.682" "430.8" "393.9" "412.0" "381.6" "410.1" "410.1" "362.9" "330.4" "369.7" "293.7" "" "" "" "" "" "" "" "" "" "" "228.1" "218.4" "236.0" "175.7" "221.9" "228.1" "213.6" "180.3" "207.4" "293.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6685402705848511390" "False" "High" "IsMasterProtein" "Q92820" "Gamma-glutamyl hydrolase OS=Homo sapiens OX=9606 GN=GGH PE=1 SV=2" "0.000" "False" "15.394" "12" "4" "6" "4" "318" "35.9" "7.11" "15.01" "4" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00117, Pf07722" "8836" "ENSG00000137563" "GGH" "hsa:8836; Q92820" "Fluoropyrimidine activity" "Neutrophil degranulation" "2" "0" "0.996" "1.045" "0.909" "0.853" "0.891" "0.799" "1.001" "0.925" "0.508" "933.2" "929.4" "975.3" "848.5" "795.8" "831.1" "745.3" "933.8" "863.3" "474.0" "" "" "" "" "" "" "" "" "" "" "494.1" "515.3" "558.6" "390.8" "430.6" "462.3" "438.6" "509.7" "484.3" "474.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7644336301377244123" "False" "High" "IsMasterProtein" "Q8IZ83" "Aldehyde dehydrogenase family 16 member A1 OS=Homo sapiens OX=9606 GN=ALDH16A1 PE=1 SV=2" "0.000" "False" "15.346" "7" "5" "9" "5" "802" "85.1" "6.79" "23.54" "5" "" "" "other molecular function" "Pf00171" "126133" "ENSG00000161618" "ALDH16A1" "B4DLQ1; C9JBH6; hsa:126133; Q86YF0; Q8IYL4; Q8IZ83; Q8TEI8" "" "" "0" "0" "0.994" "1.003" "1.045" "1.059" "0.982" "0.959" "1.059" "0.976" "0.615" "998.6" "992.4" "1001.5" "1043.4" "1057.3" "980.7" "957.8" "1057.5" "974.2" "614.1" "" "" "" "" "" "" "" "" "" "" "528.8" "550.2" "573.5" "480.5" "572.0" "545.5" "563.7" "577.3" "546.5" "614.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3973865475325375053" "False" "High" "IsMasterProtein" "P15374" "Ubiquitin carboxyl-terminal hydrolase isozyme L3 OS=Homo sapiens OX=9606 GN=UCHL3 PE=1 SV=1" "0.000" "False" "15.341" "13" "3" "8" "3" "230" "26.2" "4.92" "19.38" "3" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01088" "7347" "ENSG00000118939" "UCHL3" "B2R970; hsa:7347; P15374; Q5TBK8; Q6IBE9" "Proteasome degradation" "UCH proteinases; Neddylation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "4" "0" "1.110" "1.083" "0.969" "1.030" "1.103" "0.993" "1.191" "1.081" "1.021" "535.1" "593.8" "579.5" "518.6" "551.1" "590.0" "531.2" "637.1" "578.3" "546.6" "" "" "" "" "" "" "" "" "" "" "283.3" "329.2" "331.9" "238.8" "298.2" "328.2" "312.6" "347.8" "324.4" "546.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-437633753378296153" "False" "High" "IsMasterProtein" "Q9UKI8" "Serine/threonine-protein kinase tousled-like 1 OS=Homo sapiens OX=9606 GN=TLK1 PE=1 SV=2" "0.000" "False" "15.310" "6" "5" "6" "2" "766" "86.6" "8.72" "18.71" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "nucleus" "kinase activity;other molecular function" "Pf00069" "9874" "ENSG00000198586" "TLK1" "B3KR15; B4DX87; hsa:9874; Q14150; Q8N591; Q9NYH2; Q9UKI8; Q9Y4F6" "miRNA regulation of DNA damage response; Pathways affected in adenoid cystic carcinoma; DNA damage response" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4493401864324206702" "False" "High" "IsMasterProtein" "Q53S33" "BolA-like protein 3 OS=Homo sapiens OX=9606 GN=BOLA3 PE=1 SV=1" "0.000" "False" "15.305" "39" "4" "5" "4" "107" "12.1" "9.64" "13.26" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus" "" "Pf01722" "388962" "ENSG00000163170" "BOLA3" "G3XAB0; hsa:388962; Q53S33" "" "" "0" "0" "0.999" "1.013" "1.020" "0.995" "0.979" "1.011" "1.024" "0.941" "0.556" "824.7" "823.6" "835.6" "841.4" "820.7" "807.5" "834.2" "844.9" "775.8" "458.8" "" "" "" "" "" "" "" "" "" "" "436.7" "456.6" "478.6" "387.5" "444.0" "449.2" "491.0" "461.2" "435.2" "458.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4853611610042411436" "False" "High" "IsMasterProtein" "Q04760" "Lactoylglutathione lyase OS=Homo sapiens OX=9606 GN=GLO1 PE=1 SV=4" "0.000" "False" "15.297" "18" "5" "12" "5" "184" "20.8" "5.31" "24.46" "5" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00903" "2739" "ENSG00000124767" "GLO1" "B2R6P7; B4DDV0; hsa:2739; P78375; Q04760; Q59EL0; Q5TZW3; Q96FC0; Q96J41" "" "Pyruvate metabolism" "1" "0" "1.232" "1.073" "1.022" "1.118" "0.993" "1.034" "1.057" "1.138" "0.612" "732.9" "903.0" "786.5" "748.9" "819.6" "727.8" "757.8" "774.9" "834.3" "448.3" "" "" "" "" "" "" "" "" "" "" "388.1" "500.7" "450.4" "344.9" "443.4" "404.8" "446.0" "423.0" "468.0" "448.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6644865826182156559" "False" "High" "IsMasterProtein" "Q6DKJ4" "Nucleoredoxin OS=Homo sapiens OX=9606 GN=NXN PE=1 SV=2" "0.000" "False" "15.247" "9" "3" "3" "3" "435" "48.4" "4.97" "10.48" "3" "cell-cell signaling;developmental processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf13848, Pf13905" "64359" "ENSG00000167693" "NXN" "B4DXQ0; D3DTH2; hsa:64359; Q3SWW6; Q6DKJ4; Q6P3U6; Q7L4C6; Q9H9Q1" "" "" "0" "0" "0.925" "1.194" "1.253" "1.189" "1.123" "1.086" "1.103" "1.090" "0.831" "80.5" "74.5" "96.1" "100.9" "95.7" "90.3" "87.4" "88.8" "87.7" "66.8" "" "" "" "" "" "" "" "" "" "" "42.6" "41.3" "55.0" "46.5" "51.8" "50.2" "51.4" "48.5" "49.2" "66.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "380147253527428052" "False" "High" "IsMasterProtein" "Q9NRR5" "Ubiquilin-4 OS=Homo sapiens OX=9606 GN=UBQLN4 PE=1 SV=2" "0.000" "False" "15.239" "7" "3" "5" "3" "601" "63.8" "5.22" "11.87" "3" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf00627" "56893" "ENSG00000160803" "UBQLN4" "A6ND44; B2RAY7; hsa:56893; Q5VYA0; Q5VYA1; Q9BR98; Q9NRR5; Q9UHX4" "" "" "0" "0" "1.046" "1.155" "1.454" "1.100" "1.182" "1.174" "1.194" "1.017" "0.775" "141.1" "147.6" "163.0" "205.2" "155.1" "166.7" "165.6" "168.5" "143.5" "109.4" "" "" "" "" "" "" "" "" "" "" "74.7" "81.8" "93.4" "94.5" "83.9" "92.7" "97.5" "92.0" "80.5" "109.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4801504579459921117" "False" "High" "IsMasterProtein" "Q8IXQ3" "Uncharacterized protein C9orf40 OS=Homo sapiens OX=9606 GN=C9orf40 PE=1 SV=1" "0.000" "False" "15.219" "18" "3" "5" "3" "194" "21.1" "5.01" "14.66" "3" "" "" "" "Pf15017" "55071" "ENSG00000135045" "C9orf40" "hsa:55071; Q8IXQ3; Q9NWD3" "" "" "0" "0" "0.905" "0.895" "0.822" "0.814" "0.852" "0.720" "0.750" "0.728" "0.529" "678.8" "614.0" "607.3" "557.7" "552.4" "578.5" "488.7" "509.1" "494.4" "359.1" "" "" "" "" "" "" "" "" "" "" "359.4" "340.4" "347.8" "256.9" "298.9" "321.8" "287.6" "277.9" "277.4" "359.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1721823371863977969" "False" "High" "IsMasterProtein" "Q92973" "Transportin-1 OS=Homo sapiens OX=9606 GN=TNPO1 PE=1 SV=2" "0.000" "False" "15.191" "4" "3" "3" "2" "898" "102.3" "4.98" "12.45" "3" "transport" "cytosol;nucleus;other cell component" "other molecular function" "Pf02985, Pf03810, Pf13513" "3842" "ENSG00000083312" "TNPO1" "B4DVC6; hsa:3842; Q92957; Q92973; Q92975" "22q11.2 copy number variation syndrome" "Postmitotic nuclear pore complex (NPC) reformation; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Intraflagellar transport" "4" "0" "0.962" "1.011" "0.969" "1.007" "0.968" "0.865" "0.459" "0.812" "5.552" "254.1" "244.3" "256.9" "246.3" "256.0" "245.9" "219.7" "116.6" "206.3" "1410.5" "" "" "" "" "" "" "" "" "" "" "134.5" "135.4" "147.1" "113.4" "138.5" "136.8" "129.3" "63.6" "115.7" "1410.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4686593457953999194" "False" "High" "IsMasterProtein" "P45985" "Dual specificity mitogen-activated protein kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP2K4 PE=1 SV=1" "0.000" "False" "15.173" "10" "4" "5" "4" "399" "44.3" "8.07" "12.27" "4" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6416" "ENSG00000065559" "MAP2K4" "B2R7N7; B3KYB2; D3DTS5; hsa:6416; P45985; Q5U0B8; Q6FHX4; Q6P9H2; Q6PIE6" "MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; Glioblastoma signaling pathways; TNF-alpha signaling pathway; PDGF pathway; Apoptosis; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Fas ligand pathway and stress induction of heat shock proteins; Photodynamic therapy-induced AP-1 survival signaling; IL6 signaling pathway; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Oxidative damage response; PDGFR-beta pathway; Wnt signaling pathway and pluripotency; p38 MAPK signaling pathway; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; GNAQ pathways in port-wine stain; ErbB signaling pathway; Toll-like receptor signaling pathway" "Oxidative Stress Induced Senescence; FCERI mediated MAPK activation; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Uptake and function of anthrax toxins; MAP3K8 (TPL2)-dependent MAPK1/3 activation" "35" "0" "0.970" "1.061" "0.977" "1.017" "1.018" "0.872" "0.891" "0.863" "0.791" "425.3" "412.4" "451.0" "415.3" "432.5" "433.0" "370.6" "378.8" "366.9" "336.3" "" "" "" "" "" "" "" "" "" "" "225.2" "228.6" "258.3" "191.2" "234.0" "240.8" "218.1" "206.8" "205.8" "336.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "280272277997118017" "False" "High" "IsMasterProtein" "Q9Y316" "Protein MEMO1 OS=Homo sapiens OX=9606 GN=MEMO1 PE=1 SV=1" "0.000" "False" "15.160" "12" "4" "4" "4" "297" "33.7" "7.14" "14.16" "4" "other biological processes" "" "" "Pf01875" "51072" "ENSG00000162959" "MEMO1" "B4DLS0; D6W575; hsa:51072; Q5R2V8; Q5R2V9; Q6NSL5; Q9Y316" "" "ERBB2 Regulates Cell Motility" "1" "0" "0.917" "0.951" "0.876" "0.906" "1.004" "0.953" "1.000" "0.922" "0.664" "747.6" "685.8" "711.1" "655.1" "677.5" "750.6" "712.6" "747.3" "689.5" "496.1" "" "" "" "" "" "" "" "" "" "" "395.9" "380.2" "407.2" "301.7" "366.6" "417.5" "419.4" "407.9" "386.8" "496.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1721155162359169472" "False" "High" "IsMasterProtein" "Q9UBQ0" "Vacuolar protein sorting-associated protein 29 OS=Homo sapiens OX=9606 GN=VPS29 PE=1 SV=1" "0.000" "False" "15.144" "21" "4" "8" "4" "182" "20.5" "6.79" "22.26" "4" "transport" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf12850" "51699" "ENSG00000111237" "VPS29" "hsa:51699; Q502Y5; Q6FIF8; Q6IAH3; Q9H0W0; Q9NRP1; Q9NRU7; Q9UBQ0" "" "WNT ligand biogenesis and trafficking" "1" "0" "0.935" "1.042" "0.726" "0.872" "0.987" "0.914" "0.993" "0.998" "0.485" "572.3" "535.1" "596.6" "415.4" "498.8" "564.7" "523.0" "568.1" "571.5" "277.8" "" "" "" "" "" "" "" "" "" "" "303.1" "296.7" "341.7" "191.3" "269.9" "314.1" "307.8" "310.1" "320.6" "277.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-728646887416176304" "False" "High" "IsMasterProtein" "Q8IYL3" "UPF0688 protein C1orf174 OS=Homo sapiens OX=9606 GN=C1orf174 PE=1 SV=2" "0.000" "False" "15.138" "11" "2" "2" "2" "243" "26.0" "6.90" "8.41" "2" "" "nucleus" "" "Pf15772" "339448" "ENSG00000198912" "C1orf174" "A8K0C8; A8MUG9; hsa:339448; Q5SR20; Q6NX36; Q8IYL3" "" "" "0" "0" "0.920" "1.042" "1.024" "1.101" "1.059" "1.069" "1.154" "1.143" "0.571" "416.6" "383.3" "434.2" "426.6" "458.7" "441.0" "445.6" "480.7" "476.2" "238.0" "" "" "" "" "" "" "" "" "" "" "220.6" "212.5" "248.7" "196.5" "248.1" "245.3" "262.2" "262.4" "267.1" "238.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2093622572460603588" "False" "High" "IsMasterProtein" "Q8NBF6" "Late secretory pathway protein AVL9 homolog OS=Homo sapiens OX=9606 GN=AVL9 PE=1 SV=1" "0.000" "False" "15.135" "6" "3" "3" "3" "648" "71.9" "6.21" "9.17" "3" "other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf09794" "23080" "ENSG00000105778" "AVL9" "hsa:23080; Q8NBF6; Q92573" "" "" "0" "0" "0.993" "0.960" "1.024" "0.997" "1.015" "1.026" "1.008" "0.871" "0.777" "307.3" "305.2" "295.1" "314.8" "306.5" "311.9" "315.4" "309.8" "267.8" "238.9" "" "" "" "" "" "" "" "" "" "" "162.7" "169.2" "169.0" "145.0" "165.8" "173.5" "185.6" "169.1" "150.2" "238.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "699961986535192658" "False" "High" "IsMasterProtein" "P84095" "Rho-related GTP-binding protein RhoG OS=Homo sapiens OX=9606 GN=RHOG PE=1 SV=1" "0.000" "False" "15.117" "24" "4" "4" "3" "191" "21.3" "8.12" "12.37" "4" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00071" "391" "ENSG00000177105" "RHOG" "hsa:391; P35238; P84095; Q8NI04" "Brain-derived neurotrophic factor (BDNF) signaling pathway" "Neutrophil degranulation; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; RHOG GTPase cycle; RHO GTPases activate KTN1" "8" "0" "1.016" "0.927" "1.009" "0.983" "0.997" "0.934" "0.880" "0.916" "1.243" "454.9" "462.3" "421.6" "458.9" "447.0" "453.4" "425.1" "400.3" "416.6" "565.5" "" "" "" "" "" "" "" "" "" "" "240.9" "256.3" "241.4" "211.3" "241.8" "252.2" "250.2" "218.5" "233.7" "565.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5757828644476711483" "False" "High" "IsMasterProtein" "Q9NXR1" "Nuclear distribution protein nudE homolog 1 OS=Homo sapiens OX=9606 GN=NDE1 PE=1 SV=3" "0.000" "False" "15.104" "10" "4" "4" "4" "335" "37.7" "5.15" "13.57" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf04880" "54820" "ENSG00000072864; ENSG00000275911" "NDE1" "hsa:54820; Q49AQ2; Q9NXR1" "" "Separation of Sister Chromatids; RHO GTPases Activate Formins; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "13" "0" "1.090" "1.154" "1.046" "1.035" "1.044" "1.102" "1.169" "1.166" "0.875" "600.6" "654.6" "692.8" "628.3" "621.7" "627.0" "661.9" "702.2" "700.2" "525.4" "" "" "" "" "" "" "" "" "" "" "318.0" "362.9" "396.8" "289.3" "336.4" "348.8" "389.6" "383.3" "392.8" "525.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6159664741780628895" "False" "High" "IsMasterProtein" "Q9P2K3" "REST corepressor 3 OS=Homo sapiens OX=9606 GN=RCOR3 PE=1 SV=2" "0.000" "False" "15.104" "8" "4" "4" "4" "495" "55.5" "8.27" "11.62" "4" "other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00249, Pf01448, Pf20878" "55758" "ENSG00000117625" "RCOR3" "B3KYA2; B4DYY7; hsa:55758; Q5VT47; Q7L9I5; Q8N5U3; Q9NV83; Q9P2K3" "" "" "0" "0" "0.923" "0.903" "0.907" "0.941" "0.965" "0.988" "0.862" "0.953" "1.339" "302.4" "279.2" "273.0" "274.3" "284.7" "291.9" "298.7" "260.7" "288.0" "404.9" "" "" "" "" "" "" "" "" "" "" "160.1" "154.8" "156.3" "126.3" "154.0" "162.3" "175.8" "142.3" "161.6" "404.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3175822401937946454" "False" "High" "IsMasterProtein" "Q15942" "Zyxin OS=Homo sapiens OX=9606 GN=ZYX PE=1 SV=1" "0.000" "False" "15.096" "8" "4" "6" "4" "572" "61.2" "6.67" "21.30" "4" "cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00412" "7791" "ENSG00000159840; ENSG00000285443" "ZYX" "A4D2G6; B4DQX7; hsa:7791; Q15942; Q6I9S4" "Integrin-mediated cell adhesion; Focal adhesion" "" "2" "0" "1.032" "0.971" "0.988" "0.929" "0.932" "0.908" "1.000" "1.061" "0.510" "284.3" "293.5" "276.0" "280.9" "264.0" "265.0" "258.0" "284.2" "301.6" "145.0" "" "" "" "" "" "" "" "" "" "" "150.5" "162.7" "158.0" "129.4" "142.8" "147.4" "151.8" "155.1" "169.2" "145.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5740436620154947735" "False" "High" "IsMasterProtein" "Q9BX68" "Adenosine 5'-monophosphoramidase HINT2 OS=Homo sapiens OX=9606 GN=HINT2 PE=1 SV=1" "0.000" "False" "15.095" "20" "3" "3" "3" "163" "17.2" "9.16" "11.16" "3" "other metabolic processes;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf01230" "84681" "ENSG00000137133" "HINT2" "hsa:84681; Q5TCW3; Q9BX68" "" "RHOD GTPase cycle" "1" "0" "1.046" "1.056" "0.936" "0.969" "0.960" "0.937" "1.040" "1.001" "0.759" "460.8" "482.1" "486.5" "431.2" "446.3" "442.3" "431.6" "479.3" "461.4" "349.9" "" "" "" "" "" "" "" "" "" "" "244.0" "267.3" "278.6" "198.6" "241.5" "246.0" "254.0" "261.6" "258.8" "349.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5912307548831863099" "False" "High" "IsMasterProtein" "P25398" "Small ribosomal subunit protein eS12 OS=Homo sapiens OX=9606 GN=RPS12 PE=1 SV=3" "0.000" "False" "15.088" "27" "3" "5" "3" "132" "14.5" "7.21" "14.40" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01248" "6206" "ENSG00000112306" "RPS12" "hsa:6206; P25398; Q76M58" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.107" "1.072" "1.156" "1.006" "1.114" "1.198" "1.438" "1.335" "0.637" "206.6" "228.8" "221.5" "238.8" "207.9" "230.1" "247.5" "297.1" "275.9" "131.6" "" "" "" "" "" "" "" "" "" "" "109.4" "126.8" "126.8" "110.0" "112.5" "128.0" "145.6" "162.1" "154.8" "131.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1377000983824553191" "False" "High" "IsMasterProtein" "Q8N5N7" "Large ribosomal subunit protein mL50 OS=Homo sapiens OX=9606 GN=MRPL50 PE=1 SV=2" "0.000" "False" "15.084" "15" "2" "3" "2" "158" "18.3" "7.88" "9.76" "2" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "" "Pf10501" "54534" "ENSG00000136897" "MRPL50" "B7Z358; hsa:54534; Q5T7E0; Q8N5N7; Q9NX15" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.985" "0.899" "0.932" "0.993" "0.979" "0.816" "0.852" "0.971" "0.932" "186.7" "184.0" "167.8" "174.1" "185.4" "182.8" "152.4" "159.1" "181.3" "174.0" "" "" "" "" "" "" "" "" "" "" "98.9" "102.0" "96.1" "80.2" "100.3" "101.7" "89.7" "86.8" "101.7" "174.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2614245215378921803" "False" "High" "IsMasterProtein" "Q9UBU8" "Mortality factor 4-like protein 1 OS=Homo sapiens OX=9606 GN=MORF4L1 PE=1 SV=2" "0.000" "False" "15.072" "12" "3" "3" "2" "362" "41.4" "9.28" "8.58" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05712, Pf11717" "10933" "ENSG00000185787" "MORF4L1" "B4DKN6; B7Z6R1; D3DW88; hsa:10933; O95899; Q5QTS1; Q6NVX8; Q86YT7; Q9HBP6; Q9NSW5; Q9UBU8" "Pathways affected in adenoid cystic carcinoma" "HATs acetylate histones" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1992212741193317441" "False" "High" "IsMasterProtein" "Q13247" "Serine/arginine-rich splicing factor 6 OS=Homo sapiens OX=9606 GN=SRSF6 PE=1 SV=2" "0.000" "False" "15.063" "13" "5" "9" "4" "344" "39.6" "11.43" "21.30" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076" "6431" "ENSG00000124193" "SRSF6" "B7Z6J3; E1P5W6; hsa:6431; Q13244; Q13245; Q13247; Q96J06; Q9UJB8; Q9Y3N7" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "7" "0" "0.994" "0.972" "1.545" "1.065" "0.999" "1.122" "0.956" "0.918" "1.092" "341.0" "339.0" "331.3" "526.7" "363.2" "340.7" "382.7" "326.0" "313.0" "372.4" "" "" "" "" "" "" "" "" "" "" "180.5" "187.9" "189.7" "242.5" "196.5" "189.5" "225.2" "177.9" "175.6" "372.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5153140893326454359" "False" "High" "IsMasterProtein" "Q99496" "E3 ubiquitin-protein ligase RING2 OS=Homo sapiens OX=9606 GN=RNF2 PE=1 SV=1" "0.000" "False" "15.053" "14" "5" "5" "5" "336" "37.6" "6.84" "12.63" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13923, Pf16207" "6045" "ENSG00000121481" "RNF2" "B2RBS7; B3KRH1; Q5TEN1; Q5TEN2; Q99496" "FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Pleural mesothelioma" "SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Oxidative Stress Induced Senescence; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6" "11" "0" "1.127" "1.086" "1.162" "1.312" "1.124" "1.542" "1.664" "1.525" "1.211" "403.4" "454.8" "438.2" "468.7" "529.2" "453.5" "622.2" "671.1" "615.3" "488.5" "" "" "" "" "" "" "" "" "" "" "213.6" "252.2" "251.0" "215.8" "286.3" "252.2" "366.2" "366.3" "345.1" "488.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9147063981897791280" "False" "High" "IsMasterProtein" "P04632" "Calpain small subunit 1 OS=Homo sapiens OX=9606 GN=CAPNS1 PE=1 SV=1" "0.000" "False" "15.051" "10" "2" "3" "2" "268" "28.3" "5.20" "8.72" "2" "protein metabolism;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "" "826" "ENSG00000126247" "CAPNS1" "A8K0P1; hsa:826; P04632; Q8WTX3; Q96EW0" "Integrin-mediated cell adhesion" "Formation of the cornified envelope; Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "4" "0" "0.962" "1.088" "1.117" "1.066" "0.980" "1.157" "1.040" "0.873" "0.766" "216.4" "208.3" "235.3" "241.7" "230.7" "212.1" "250.4" "225.2" "189.0" "165.8" "" "" "" "" "" "" "" "" "" "" "114.6" "115.5" "134.8" "111.3" "124.8" "118.0" "147.4" "122.9" "106.0" "165.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-867231523467416798" "False" "High" "IsMasterProtein" "Q6K0P9" "Pyrin and HIN domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PYHIN1 PE=1 SV=1" "0.000" "False" "15.042" "11" "5" "7" "3" "492" "55.0" "9.80" "19.27" "5" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02758, Pf02760" "149628" "ENSG00000163564" "PYHIN1" "hsa:149628; Q5T3W6; Q6K0P6; Q6K0P7; Q6K0P8; Q6K0P9; Q8WW65" "" "" "0" "0" "1.383" "1.005" "1.000" "0.933" "1.129" "1.181" "0.558" "1.007" "5.502" "19.7" "27.2" "19.8" "19.7" "18.3" "22.2" "23.2" "11.0" "19.8" "108.2" "" "" "" "" "" "" "" "" "" "" "10.4" "15.1" "11.3" "9.1" "9.9" "12.4" "13.7" "6.0" "11.1" "108.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3137976061761612537" "False" "High" "IsMasterProtein" "Q16512" "Serine/threonine-protein kinase N1 OS=Homo sapiens OX=9606 GN=PKN1 PE=1 SV=2" "0.000" "False" "15.041" "6" "6" "6" "6" "942" "103.9" "6.37" "9.59" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433, Pf02185" "5585" "ENSG00000123143" "PKN1" "A8K7W5; B2R9R4; B3KVN3; hsa:5585; Q15143; Q16512; Q504U4; Q8IUV5; Q9UD44" "Apoptosis-related network due to altered Notch3 in ovarian cancer; PI3K-Akt signaling pathway; IL-18 signaling pathway; G13 signaling pathway" "RHOA GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; RHOC GTPase cycle" "10" "0" "0.985" "0.996" "0.993" "0.888" "0.912" "0.994" "0.975" "0.969" "1.319" "313.9" "309.3" "312.7" "311.6" "278.6" "286.3" "312.0" "306.0" "304.1" "414.0" "" "" "" "" "" "" "" "" "" "" "166.2" "171.5" "179.1" "143.5" "150.7" "159.3" "183.6" "167.1" "170.6" "414.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6302134313779443403" "False" "High" "IsMasterProtein" "Q96ER3" "Protein SAAL1 OS=Homo sapiens OX=9606 GN=SAAL1 PE=1 SV=2" "0.000" "False" "15.031" "8" "4" "4" "4" "474" "53.5" "4.50" "10.74" "4" "other biological processes" "nucleus" "" "" "113174" "ENSG00000166788" "SAAL1" "A6NH05; hsa:113174; Q96ER3" "" "" "0" "0" "1.029" "1.041" "1.016" "1.050" "1.197" "1.219" "1.217" "1.341" "1.295" "525.6" "540.9" "547.2" "534.1" "552.0" "629.2" "640.6" "639.4" "704.8" "680.4" "" "" "" "" "" "" "" "" "" "" "278.3" "299.9" "313.4" "246.0" "298.6" "350.0" "377.0" "349.0" "395.4" "680.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4459435427997336669" "False" "High" "IsMasterProtein" "O60231" "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 OS=Homo sapiens OX=9606 GN=DHX16 PE=1 SV=2" "0.000" "False" "15.027" "5" "6" "6" "6" "1041" "119.2" "6.80" "15.94" "6" "RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "8449" "ENSG00000204560; ENSG00000206486; ENSG00000226171; ENSG00000231377; ENSG00000233049; ENSG00000233418; ENSG00000233561" "DHX16" "hsa:8449; O60231; O60322; Q5JP45; Q969X7; Q96QC1" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.944" "1.023" "1.137" "1.119" "1.048" "1.170" "1.122" "1.298" "2.182" "313.3" "295.8" "320.5" "356.0" "350.6" "328.3" "366.6" "351.6" "406.8" "683.5" "" "" "" "" "" "" "" "" "" "" "165.9" "164.0" "183.5" "164.0" "189.7" "182.6" "215.8" "191.9" "228.2" "683.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "545176652009721876" "False" "High" "IsMasterProtein" "Q9P013" "Spliceosome-associated protein CWC15 homolog OS=Homo sapiens OX=9606 GN=CWC15 PE=1 SV=2" "0.000" "False" "15.023" "17" "4" "4" "4" "229" "26.6" "5.71" "10.21" "4" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf04889" "51503" "ENSG00000150316" "CWC15" "B2RC17; hsa:51503; Q05BV9; Q05DM1; Q9P013; Q9UI29" "" "mRNA Splicing - Major Pathway" "1" "0" "0.907" "0.988" "0.949" "0.959" "0.893" "1.079" "1.041" "1.037" "0.323" "774.1" "702.5" "765.2" "734.8" "742.7" "691.2" "835.0" "805.6" "802.8" "249.7" "" "" "" "" "" "" "" "" "" "" "409.9" "389.5" "438.2" "338.4" "401.8" "384.5" "491.4" "439.7" "450.3" "249.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-580559568770530829" "False" "High" "IsMasterProtein" "Q14135" "Transcription cofactor vestigial-like protein 4 OS=Homo sapiens OX=9606 GN=VGLL4 PE=1 SV=4" "0.000" "False" "14.974" "22" "4" "4" "4" "290" "30.9" "8.22" "6.29" "4" "other biological processes" "nucleus" "other molecular function" "Pf15245" "9686" "ENSG00000144560" "VGLL4" "B4DTS7; hsa:9686; J3KN68; Q14135; Q7L5V0; Q9BQ78" "Hippo-Merlin signaling dysregulation; Pleural mesothelioma" "" "2" "0" "1.040" "1.131" "1.054" "1.099" "1.040" "0.899" "1.085" "0.951" "0.572" "294.3" "305.9" "332.9" "310.1" "323.3" "305.9" "264.4" "319.3" "279.9" "168.3" "" "" "" "" "" "" "" "" "" "" "155.8" "169.6" "190.6" "142.8" "174.9" "170.2" "155.6" "174.3" "157.0" "168.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1811724669038293962" "False" "High" "IsMasterProtein" "Q96RP9" "Elongation factor G, mitochondrial OS=Homo sapiens OX=9606 GN=GFM1 PE=1 SV=2" "0.000" "False" "14.961" "6" "5" "6" "5" "751" "83.4" "7.01" "14.76" "5" "protein metabolism;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" "85476" "ENSG00000168827" "GFM1" "A6NCI9; B2RCB9; B3KRW1; hsa:85476; Q6GTN2; Q96RP9; Q96T39" "" "Mitochondrial translation elongation" "1" "0" "0.915" "0.875" "0.821" "0.906" "0.995" "0.804" "0.595" "0.809" "3.293" "440.1" "402.9" "385.3" "361.1" "398.8" "438.0" "354.0" "262.0" "356.2" "1449.5" "" "" "" "" "" "" "" "" "" "" "233.0" "223.4" "220.7" "166.3" "215.8" "243.7" "208.3" "143.0" "199.8" "1449.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "247879969936268411" "False" "High" "IsMasterProtein" "O94992" "Protein HEXIM1 OS=Homo sapiens OX=9606 GN=HEXIM1 PE=1 SV=1" "0.000" "False" "14.944" "13" "5" "7" "5" "359" "40.6" "4.89" "21.58" "5" "stress response;developmental processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf15313" "10614" "ENSG00000186834" "HEXIM1" "B2R8Y5; hsa:10614; O94992" "Initiation of transcription and translation elongation at the HIV-1 LTR" "" "1" "0" "1.019" "1.009" "0.994" "0.977" "0.958" "1.048" "1.043" "1.028" "0.635" "849.5" "865.5" "857.4" "844.5" "829.6" "814.2" "890.5" "886.1" "873.5" "539.6" "" "" "" "" "" "" "" "" "" "" "449.8" "479.9" "491.0" "388.9" "448.9" "452.9" "524.1" "483.7" "490.0" "539.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5446146544739154360" "False" "High" "IsMasterProtein" "Q15654" "Thyroid receptor-interacting protein 6 OS=Homo sapiens OX=9606 GN=TRIP6 PE=1 SV=3" "0.000" "False" "14.926" "10" "5" "5" "5" "476" "50.3" "7.37" "13.15" "5" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00412" "7205" "ENSG00000087077" "TRIP6" "A4D2E7; F2ZC07; F2ZC08; hsa:7205; O15170; O15275; Q15654; Q9BTB2; Q9BUE5; Q9BXP3; Q9UNT4" "" "" "0" "0" "1.002" "0.906" "0.819" "0.935" "0.901" "1.071" "1.189" "1.117" "0.834" "210.0" "210.5" "190.2" "172.1" "196.3" "189.2" "224.9" "249.8" "234.5" "175.1" "" "" "" "" "" "" "" "" "" "" "111.2" "116.7" "108.9" "79.3" "106.2" "105.2" "132.4" "136.3" "131.6" "175.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-116543853618974429" "False" "High" "IsMasterProtein" "P20338" "Ras-related protein Rab-4A OS=Homo sapiens OX=9606 GN=RAB4A PE=1 SV=3" "0.000" "False" "14.916" "21" "4" "4" "4" "218" "24.4" "6.07" "9.89" "4" "transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5867" "ENSG00000168118" "RAB4A" "hsa:5867; P20338; Q5T7P7; Q9BQ44" "VEGFA-VEGFR2 signaling; Insulin signaling; Intracellular trafficking proteins involved in CMT neuropathy; 16p11.2 distal deletion syndrome" "TBC/RABGAPs; RAB geranylgeranylation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Synthesis of PIPs at the plasma membrane; MET receptor recycling" "9" "0" "1.321" "0.993" "1.109" "1.261" "1.160" "1.085" "1.000" "0.998" "0.778" "598.3" "790.1" "594.1" "663.6" "754.5" "693.9" "649.3" "598.2" "596.9" "465.4" "" "" "" "" "" "" "" "" "" "" "316.8" "438.0" "340.2" "305.6" "408.2" "386.0" "382.1" "326.5" "334.9" "465.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5412542927183305238" "False" "High" "IsMasterProtein" "P17535" "Transcription factor JunD OS=Homo sapiens OX=9606 GN=JUND PE=1 SV=3" "0.000" "False" "14.883" "10" "4" "4" "3" "347" "35.2" "7.37" "13.52" "4" "other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf03957" "3727" "ENSG00000130522" "JUND" "hsa:3727; P17535; Q53EK9" "Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; TGF-beta signaling pathway; MAPK signaling pathway; EGF/EGFR signaling pathway; Angiotensin II receptor type 1 pathway; Hypertrophy model; 10q11.21q11.23 copy number variation syndrome; Osteoarthritic chondrocyte hypertrophy" "NGF-stimulated transcription; Estrogen-dependent gene expression" "14" "1" "0.933" "1.069" "1.076" "0.960" "0.943" "0.979" "1.103" "1.081" "0.749" "802.1" "748.8" "857.8" "863.3" "770.1" "756.5" "785.6" "884.8" "867.3" "600.6" "" "" "" "" "" "" "" "" "" "" "424.7" "415.1" "491.2" "397.6" "416.6" "420.8" "462.4" "483.0" "486.5" "600.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7972522835468462088" "False" "High" "IsMasterProtein" "O43432" "Eukaryotic translation initiation factor 4 gamma 3 OS=Homo sapiens OX=9606 GN=EIF4G3 PE=1 SV=2" "0.000" "False" "14.877" "3" "4" "5" "2" "1585" "176.5" "5.38" "9.43" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf02020, Pf02847, Pf02854" "8672" "ENSG00000075151" "EIF4G3" "B9EGQ7; hsa:8672; O43432; Q15597; Q504Z1; Q5SWC3; Q8NEN1" "Translation factors; Translation inhibitors in chronically activated PDGFRA cells" "ISG15 antiviral mechanism" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3497794903438612376" "False" "High" "IsMasterProtein" "Q92541" "RNA polymerase-associated protein RTF1 homolog OS=Homo sapiens OX=9606 GN=RTF1 PE=1 SV=4" "0.000" "False" "14.876" "8" "6" "9" "6" "710" "80.3" "8.15" "21.85" "6" "cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus" "nucleic acid binding activity" "Pf03126" "23168" "ENSG00000137815" "RTF1" "hsa:23168; Q92541; Q96BX6" "Endoderm differentiation" "E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "5" "0" "0.977" "1.036" "1.023" "1.063" "1.091" "0.968" "0.902" "0.966" "1.370" "835.5" "816.0" "865.9" "854.3" "888.5" "911.2" "808.6" "753.2" "807.2" "1144.4" "" "" "" "" "" "" "" "" "" "" "442.4" "452.4" "495.9" "393.4" "480.7" "506.9" "475.9" "411.2" "452.8" "1144.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7480340352347879805" "False" "High" "IsMasterProtein" "Q99459" "Cell division cycle 5-like protein OS=Homo sapiens OX=9606 GN=CDC5L PE=1 SV=2" "0.000" "False" "14.869" "5" "4" "4" "4" "802" "92.2" "8.18" "10.39" "4" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11831, Pf13921" "988" "ENSG00000096401" "CDC5L" "hsa:988; Q76N46; Q99459; Q99974" "" "mRNA Splicing - Major Pathway" "1" "0" "1.073" "1.003" "1.185" "1.148" "1.084" "1.909" "1.761" "1.710" "2.131" "134.1" "143.9" "134.4" "158.8" "153.9" "145.3" "255.9" "236.1" "229.2" "285.7" "" "" "" "" "" "" "" "" "" "" "71.0" "79.8" "77.0" "73.2" "83.3" "80.8" "150.6" "128.9" "128.6" "285.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7722178459817833286" "False" "High" "IsMasterProtein" "P61970" "Nuclear transport factor 2 OS=Homo sapiens OX=9606 GN=NUTF2 PE=1 SV=1" "0.000" "False" "14.861" "30" "3" "9" "3" "127" "14.5" "5.38" "22.54" "3" "transport;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf02136" "10204" "ENSG00000102898" "NUTF2" "B2R4G7; hsa:10204; P13662; P61970; Q6IB67" "" "" "0" "0" "0.963" "0.997" "0.947" "1.113" "1.085" "0.993" "1.116" "1.170" "0.597" "560.1" "539.1" "558.6" "530.4" "623.5" "607.7" "556.4" "625.1" "655.1" "334.6" "" "" "" "" "" "" "" "" "" "" "296.6" "298.9" "319.9" "244.3" "337.3" "338.0" "327.4" "341.2" "367.5" "334.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5200719085873833637" "False" "High" "IsMasterProtein" "Q8NFW8" "N-acylneuraminate cytidylyltransferase OS=Homo sapiens OX=9606 GN=CMAS PE=1 SV=2" "0.000" "False" "14.855" "11" "4" "5" "4" "434" "48.3" "7.93" "14.01" "4" "other metabolic processes" "nucleus" "other molecular function" "Pf02348" "55907" "ENSG00000111726" "CMAS" "hsa:55907; Q8NFW8; Q96AX5; Q9NQZ0" "Sialylation" "Sialic acid metabolism" "2" "0" "0.988" "0.910" "1.042" "1.135" "1.063" "0.940" "0.927" "0.951" "1.718" "229.6" "226.8" "209.0" "239.1" "260.7" "244.1" "215.9" "212.8" "218.3" "394.5" "" "" "" "" "" "" "" "" "" "" "121.6" "125.7" "119.7" "110.1" "141.0" "135.8" "127.1" "116.1" "122.5" "394.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1040458896990308382" "False" "High" "IsMasterProtein" "Q9Y5J7" "Mitochondrial import inner membrane translocase subunit Tim9 OS=Homo sapiens OX=9606 GN=TIMM9 PE=1 SV=1" "0.000" "False" "14.843" "35" "3" "5" "3" "89" "10.4" "7.21" "16.49" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf02953" "26520" "ENSG00000100575" "TIMM9" "B2R584; hsa:26520; Q9Y5J7" "" "Mitochondrial protein degradation; Mitochondrial protein import" "2" "0" "0.936" "1.010" "0.826" "0.941" "0.982" "0.884" "1.053" "0.975" "0.370" "1021.5" "956.1" "1031.6" "844.1" "961.6" "1003.3" "902.6" "1076.1" "996.3" "377.6" "" "" "" "" "" "" "" "" "" "" "540.9" "530.1" "590.8" "388.7" "520.3" "558.1" "531.2" "587.4" "558.9" "377.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6174880606405183757" "False" "High" "IsMasterProtein" "P56545" "C-terminal-binding protein 2 OS=Homo sapiens OX=9606 GN=CTBP2 PE=1 SV=1" "0.000" "False" "14.841" "11" "6" "7" "2" "445" "48.9" "6.95" "18.87" "6" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00389, Pf02826" "1488" "ENSG00000175029" "CTBP2" "A8K2X5; D3DRF5; hsa:1488; O43449; P56545; Q5SQP7; Q69YI3; Q86SV0; Q8IY44; Q9H2T8" "Neural crest differentiation; Notch signaling; Mesodermal commitment pathway; Wnt signaling pathway and pluripotency; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Pleural mesothelioma" "Repression of WNT target genes; Signaling by TCF7L2 mutants" "11" "0" "1.073" "0.978" "1.010" "0.885" "0.944" "0.924" "0.941" "0.935" "0.775" "212.5" "228.1" "207.9" "214.7" "188.1" "200.7" "196.5" "199.9" "198.8" "164.8" "" "" "" "" "" "" "" "" "" "" "112.5" "126.4" "119.1" "98.9" "101.8" "111.6" "115.6" "109.1" "111.5" "164.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1416539979039474058" "False" "High" "IsMasterProtein" "Q99426" "Tubulin-folding cofactor B OS=Homo sapiens OX=9606 GN=TBCB PE=1 SV=2" "0.000" "False" "14.838" "18" "5" "6" "5" "244" "27.3" "5.15" "17.59" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf01302, Pf14560" "1155" "ENSG00000105254" "TBCB" "hsa:1155; O00111; O00674; O14728; Q6FGY5; Q99426" "" "Post-chaperonin tubulin folding pathway" "1" "0" "1.017" "0.974" "1.047" "0.897" "0.942" "0.940" "0.823" "0.949" "2.690" "361.5" "367.5" "352.0" "378.4" "324.3" "340.5" "339.8" "297.7" "343.0" "972.5" "" "" "" "" "" "" "" "" "" "" "191.4" "203.7" "201.6" "174.3" "175.5" "189.4" "200.0" "162.5" "192.4" "972.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1318153562653389017" "False" "High" "IsMasterProtein" "O43837" "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3B PE=1 SV=2" "0.000" "False" "14.827" "12" "5" "7" "5" "385" "42.2" "8.46" "17.36" "5" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00180" "3420" "ENSG00000101365" "IDH3B" "B2RDR1; D3DVX2; D3DVX3; hsa:3420; O43837; O95106; Q5JXS8; Q9NQ06; Q9NQ07; Q9NUZ0; Q9UEX0; Q9UG99" "TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle)" "2" "0" "0.973" "0.914" "0.921" "0.959" "0.882" "0.908" "0.787" "0.875" "1.024" "338.5" "329.4" "309.5" "311.7" "324.6" "298.6" "307.5" "266.4" "296.3" "346.7" "" "" "" "" "" "" "" "" "" "" "179.2" "182.6" "177.2" "143.5" "175.6" "166.1" "181.0" "145.4" "166.2" "346.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4718319405373936898" "False" "High" "IsMasterProtein" "Q5TA45" "Integrator complex subunit 11 OS=Homo sapiens OX=9606 GN=INTS11 PE=1 SV=2" "0.000" "False" "14.802" "7" "4" "4" "4" "600" "67.6" "8.06" "12.74" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07521, Pf10996, Pf16661, Pf21386" "54973" "ENSG00000127054" "INTS11" "A8K5S2; B3KPR3; B4DM87; G3V1S5; hsa:54973; Q5TA45; Q5TA46; Q5TA48; Q5TA52; Q5TA53; Q5TA54; Q7L3D7; Q96HY1; Q9BW36; Q9H0F9; Q9H8R5; Q9HAA6; Q9NWX9" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "0.954" "1.080" "1.120" "1.229" "1.073" "1.050" "1.081" "1.093" "1.007" "175.4" "167.3" "189.4" "196.4" "215.6" "188.2" "184.2" "189.5" "191.7" "176.7" "" "" "" "" "" "" "" "" "" "" "92.9" "92.8" "108.4" "90.5" "116.6" "104.7" "108.4" "103.5" "107.5" "176.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3824226989303919527" "False" "High" "IsMasterProtein" "Q68EM7" "Rho GTPase-activating protein 17 OS=Homo sapiens OX=9606 GN=ARHGAP17 PE=1 SV=1" "0.000" "False" "14.792" "5" "5" "5" "5" "881" "95.4" "7.62" "13.39" "5" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00620, Pf03114" "55114" "ENSG00000140750; ENSG00000288353" "ARHGAP17" "A8K6M6; hsa:55114; Q68EM7; Q6ZUS4; Q7Z2F2; Q8NDG2; Q96KS2; Q96KS3; Q96SS8; Q9BVF6; Q9H8U5; Q9NW54" "" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle" "6" "0" "0.963" "1.066" "1.033" "1.009" "1.140" "1.053" "0.416" "1.062" "8.940" "196.1" "188.8" "208.9" "202.5" "197.8" "223.6" "206.5" "81.6" "208.2" "1752.7" "" "" "" "" "" "" "" "" "" "" "103.8" "104.7" "119.6" "93.2" "107.0" "124.4" "121.5" "44.5" "116.8" "1752.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2297110738803864325" "False" "High" "IsMasterProtein" "P30044" "Peroxiredoxin-5, mitochondrial OS=Homo sapiens OX=9606 GN=PRDX5 PE=1 SV=4" "0.000" "False" "14.767" "17" "3" "6" "3" "214" "22.1" "8.70" "18.95" "3" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf08534" "25824" "ENSG00000126432" "PRDX5" "A6NC19; A6NG06; B7ZLJ4; B7ZVW3; hsa:25824; P30044; Q14CK0; Q6IAF2; Q9UBU5; Q9UJU4; Q9UKX4" "Selenium micronutrient network" "" "1" "0" "1.131" "0.992" "1.193" "1.091" "1.079" "1.150" "0.948" "0.894" "0.682" "168.1" "190.1" "166.7" "200.4" "183.3" "181.3" "193.3" "159.3" "150.2" "114.7" "" "" "" "" "" "" "" "" "" "" "89.0" "105.4" "95.5" "92.3" "99.2" "100.8" "113.8" "86.9" "84.3" "114.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1581896134396951467" "False" "High" "IsMasterProtein" "P49006" "MARCKS-related protein OS=Homo sapiens OX=9606 GN=MARCKSL1 PE=1 SV=2" "0.000" "False" "14.756" "18" "3" "9" "3" "195" "19.5" "4.67" "22.74" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf02063" "65108" "ENSG00000175130" "MARCKSL1" "D3DPQ0; hsa:65108; P49006; Q5TEE6; Q6NXS5" "" "" "0" "0" "1.035" "1.045" "1.042" "0.919" "0.886" "0.983" "0.901" "0.935" "0.653" "144.1" "149.2" "150.6" "150.2" "132.4" "127.7" "141.6" "129.8" "134.8" "94.1" "" "" "" "" "" "" "" "" "" "" "76.3" "82.7" "86.2" "69.2" "71.6" "71.0" "83.4" "70.9" "75.6" "94.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3455107625301328378" "False" "High" "IsMasterProtein" "Q86TX2" "Acyl-coenzyme A thioesterase 1 OS=Homo sapiens OX=9606 GN=ACOT1 PE=1 SV=1" "0.000" "False" "14.751" "10" "4" "6" "4" "421" "46.2" "7.34" "14.39" "4" "other metabolic processes" "cytosol" "other molecular function" "Pf04775, Pf08840" "641371" "ENSG00000184227" "ACOT1" "A1L173; hsa:641371; Q3I5F9; Q86TX2" "" "Mitochondrial Fatty Acid Beta-Oxidation" "1" "0" "1.073" "0.964" "1.180" "1.008" "1.044" "1.138" "1.029" "1.086" "1.191" "227.8" "244.5" "219.5" "268.8" "229.7" "237.9" "259.2" "234.4" "247.4" "271.4" "" "" "" "" "" "" "" "" "" "" "120.6" "135.5" "125.7" "123.8" "124.3" "132.3" "152.6" "128.0" "138.8" "271.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7890686096526149286" "False" "High" "IsMasterProtein" "Q13347" "Eukaryotic translation initiation factor 3 subunit I OS=Homo sapiens OX=9606 GN=EIF3I PE=1 SV=1" "0.000" "False" "14.733" "10" "3" "5" "3" "325" "36.5" "5.64" "15.22" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00400, Pf12894" "8668" "ENSG00000084623" "EIF3I" "hsa:8668; Q13347" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "0" "1.567" "1.085" "1.442" "1.420" "1.275" "1.288" "1.044" "1.032" "1.450" "53.4" "83.7" "57.9" "77.0" "75.8" "68.1" "68.7" "55.7" "55.1" "77.4" "" "" "" "" "" "" "" "" "" "" "28.3" "46.4" "33.2" "35.5" "41.0" "37.9" "40.5" "30.4" "30.9" "77.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "896567990825277729" "False" "High" "IsMasterProtein" "O94925" "Glutaminase kidney isoform, mitochondrial OS=Homo sapiens OX=9606 GN=GLS PE=1 SV=1" "0.000" "False" "14.731" "5" "2" "2" "2" "669" "73.4" "7.77" "8.58" "2" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf04960, Pf12796, Pf17959" "2744" "ENSG00000115419" "GLS" "hsa:2744; O94925; Q9UL05; Q9UL06; Q9UL07; Q9UN40" "Amino acid metabolism; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells; Cell lineage map for neuronal differentiation" "Glutamate Neurotransmitter Release Cycle; TP53 Regulates Metabolic Genes; Glutamate and glutamine metabolism" "8" "0" "1.063" "1.164" "1.113" "1.249" "1.139" "1.079" "1.037" "0.912" "1.371" "199.1" "211.6" "231.7" "221.6" "248.7" "226.8" "214.8" "206.4" "181.6" "273.0" "" "" "" "" "" "" "" "" "" "" "105.4" "117.3" "132.7" "102.1" "134.6" "126.2" "126.4" "112.7" "101.9" "273.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3266332044031462775" "False" "High" "IsMasterProtein" "O43324" "Eukaryotic translation elongation factor 1 epsilon-1 OS=Homo sapiens OX=9606 GN=EEF1E1 PE=1 SV=1" "0.000" "False" "14.715" "17" "3" "5" "3" "174" "19.8" "8.54" "14.97" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00043" "9521" "ENSG00000124802" "EEF1E1" "C9JLK5; hsa:9521; O43324; Q5THS2" "" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "2" "0" "0.964" "1.027" "1.070" "1.029" "1.091" "0.932" "0.740" "1.342" "4.595" "382.4" "368.8" "392.8" "409.1" "393.5" "417.1" "356.4" "282.9" "513.4" "1757.2" "" "" "" "" "" "" "" "" "" "" "202.5" "204.5" "224.9" "188.4" "212.9" "232.0" "209.7" "154.4" "288.0" "1757.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7090269578477503572" "False" "High" "IsMasterProtein" "P29353" "SHC-transforming protein 1 OS=Homo sapiens OX=9606 GN=SHC1 PE=1 SV=4" "0.000" "False" "14.711" "7" "4" "4" "4" "583" "62.8" "6.44" "12.43" "4" "cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00640" "6464" "ENSG00000160691" "SHC1" "B5BU19; D3DV78; hsa:6464; O15290; P29353; Q5T180; Q5T183; Q5T184; Q5T185; Q5T186; Q8N4K5; Q96CL1" "IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL6 signaling pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; p38 MAPK signaling pathway; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; EGF/EGFR signaling pathway; Fragile X syndrome; Gastrin signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Pleural mesothelioma; GDNF signaling; Macrophage-stimulating protein (MSP) signaling network map; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; RET signaling; Interleukin receptor SHC signaling; RAF/MAP kinase cascade; Tie2 Signaling; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; Signaling by CSF3 (G-CSF); XBP1(S) activates chaperone genes; SHC1 events in EGFR signaling; Signaling by CSF1 (M-CSF) in myeloid cells; Integrin signaling; Erythropoietin activates RAS; Signalling to RAS; Signal attenuation; Interleukin-2 signaling; Interleukin-15 signaling" "65" "0" "1.174" "1.050" "1.114" "1.123" "1.007" "1.065" "1.102" "0.999" "0.825" "445.5" "522.9" "467.6" "496.2" "500.4" "448.4" "474.6" "490.9" "445.2" "367.7" "" "" "" "" "" "" "" "" "" "" "235.9" "289.9" "267.8" "228.5" "270.7" "249.4" "279.3" "268.0" "249.7" "367.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "506200805167063951" "False" "High" "IsMasterProtein" "P42229" "Signal transducer and activator of transcription 5A OS=Homo sapiens OX=9606 GN=STAT5A PE=1 SV=1" "0.000" "False" "14.663" "6" "5" "6" "5" "794" "90.6" "6.39" "14.50" "5" "other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf21354" "6776" "ENSG00000126561" "STAT5A" "hsa:6776; P42229; Q1KLZ6" "IL-5 signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mammary gland development pathway - Puberty (Stage 2 of 4); Hematopoietic stem cell differentiation; IL-3 signaling pathway; Kit receptor signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Physico-chemical features and toxicity-associated pathways; TYROBP causal network in microglia; IL-4 signaling pathway; PDGFR-beta pathway; White fat cell differentiation; Non-small cell lung cancer; EGF/EGFR signaling pathway; Measles virus infection; Hepatitis B infection; IL-2 signaling pathway; 3q29 copy number variation syndrome; FOXP3 in COVID-19; Th17 cell differentiation pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2; Acute myeloid leukemia; JAK-STAT signaling in the regulation of beta cells; EPO receptor signaling; Interferon type I signaling pathways; ErbB signaling pathway" "Signaling by cytosolic FGFR1 fusion mutants; Interleukin-3, Interleukin-5 and GM-CSF signaling; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Growth hormone receptor signaling; Nuclear signaling by ERBB4; Signaling by Leptin; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Prolactin receptor signaling; Interleukin-20 family signaling; Erythropoietin activates STAT5; Signaling by FLT3 fusion proteins; Interleukin-2 signaling; Nuclear events stimulated by ALK signaling in cancer; STAT5 activation downstream of FLT3 ITD mutants; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling; STAT5 Activation" "54" "0" "1.048" "0.980" "1.218" "1.029" "0.979" "1.064" "0.818" "1.048" "4.323" "162.5" "170.4" "159.3" "197.9" "167.2" "159.1" "172.8" "133.0" "170.3" "702.5" "" "" "" "" "" "" "" "" "" "" "86.0" "94.5" "91.2" "91.1" "90.5" "88.5" "101.7" "72.6" "95.6" "702.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5658103532290025162" "False" "High" "IsMasterProtein" "P49770" "Translation initiation factor eIF2B subunit beta OS=Homo sapiens OX=9606 GN=EIF2B2 PE=1 SV=3" "0.000" "False" "14.660" "15" "5" "5" "5" "351" "39.0" "6.16" "11.40" "5" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01008" "8892" "ENSG00000119718" "EIF2B2" "hsa:8892; O43201; P49770" "Translation factors; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Rett syndrome; Primary ovarian insufficiency" "Recycling of eIF2:GDP" "5" "0" "1.072" "0.996" "0.997" "1.024" "1.032" "0.954" "0.935" "0.976" "0.828" "789.3" "846.3" "786.0" "786.9" "808.5" "814.5" "752.7" "737.7" "770.5" "653.6" "" "" "" "" "" "" "" "" "" "" "417.9" "469.2" "450.1" "362.4" "437.4" "453.1" "443.0" "402.7" "432.3" "653.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1799847195195984928" "False" "High" "IsMasterProtein" "Q5VYK3" "Proteasome adapter and scaffold protein ECM29 OS=Homo sapiens OX=9606 GN=ECPAS PE=1 SV=2" "0.000" "False" "14.659" "2" "4" "5" "4" "1845" "204.2" "7.12" "15.66" "4" "cell organization and biogenesis" "cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf12755, Pf13001" "23392" "ENSG00000136813" "ECPAS" "A0A804HJA4; B3KXF2; O15074; Q5VYK3; Q8WU82" "" "" "0" "0" "1.124" "1.149" "1.541" "1.052" "1.040" "1.039" "0.881" "0.906" "5.574" "78.3" "88.0" "89.9" "120.6" "82.3" "81.4" "81.3" "69.0" "70.9" "436.2" "" "" "" "" "" "" "" "" "" "" "41.4" "48.8" "51.5" "55.6" "44.5" "45.3" "47.8" "37.6" "39.8" "436.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5779519367271372583" "False" "High" "IsMasterProtein" "Q15645" "Pachytene checkpoint protein 2 homolog OS=Homo sapiens OX=9606 GN=TRIP13 PE=1 SV=2" "0.000" "False" "14.657" "6" "3" "5" "3" "432" "48.5" "6.09" "14.11" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00004" "9319" "ENSG00000071539" "TRIP13" "C9K0T3; D3DTC0; hsa:9319; O15324; Q15645" "Male infertility" "" "1" "0" "1.022" "1.025" "1.022" "1.092" "1.063" "0.920" "0.902" "0.922" "0.967" "519.4" "530.7" "532.3" "530.6" "567.1" "552.3" "477.8" "468.7" "479.0" "502.2" "" "" "" "" "" "" "" "" "" "" "275.0" "294.3" "304.8" "244.4" "306.8" "307.2" "281.2" "255.8" "268.7" "502.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2799145337949175211" "False" "High" "IsMasterProtein" "O15294" "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Homo sapiens OX=9606 GN=OGT PE=1 SV=3" "0.000" "False" "14.652" "5" "5" "6" "5" "1046" "116.9" "6.70" "15.71" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00515, Pf13181, Pf13414, Pf13424, Pf13844" "8473" "ENSG00000147162" "OGT" "hsa:8473; O15294; Q7Z3K0; Q8WWM8; Q96CC1; Q9UG57" "Ectoderm differentiation; Ectoderm differentiation; Pleural mesothelioma" "UCH proteinases; Formation of WDR5-containing histone-modifying complexes; Regulation of necroptotic cell death; HATs acetylate histones" "8" "0" "1.018" "0.995" "1.078" "0.968" "1.063" "1.016" "0.775" "0.992" "2.224" "532.3" "541.8" "529.7" "574.0" "515.3" "565.9" "541.0" "412.4" "527.8" "1183.9" "" "" "" "" "" "" "" "" "" "" "281.9" "300.4" "303.3" "264.3" "278.8" "314.8" "318.4" "225.1" "296.1" "1183.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3758284595644048114" "False" "High" "IsMasterProtein" "P78345" "Ribonuclease P protein subunit p38 OS=Homo sapiens OX=9606 GN=RPP38 PE=1 SV=2" "0.000" "False" "14.601" "14" "3" "5" "3" "283" "31.8" "9.92" "13.82" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01248" "10557" "ENSG00000152464" "RPP38" "B3KPY0; D3DRT8; hsa:10557; P78345; Q53F71; Q8NHS8" "Sphingolipid metabolism in senescence" "Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus" "3" "0" "1.034" "0.824" "1.618" "1.400" "1.068" "1.329" "1.079" "0.875" "0.916" "21.2" "21.9" "17.4" "34.3" "29.7" "22.6" "28.1" "22.9" "18.5" "19.4" "" "" "" "" "" "" "" "" "" "" "11.2" "12.1" "10.0" "15.8" "16.0" "12.6" "16.6" "12.5" "10.4" "19.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5987314834012537405" "False" "High" "IsMasterProtein" "O60888" "Protein CutA OS=Homo sapiens OX=9606 GN=CUTA PE=1 SV=2" "0.000" "False" "14.599" "15" "2" "6" "2" "179" "19.1" "5.50" "18.78" "2" "other biological processes" "other membranes" "other molecular function" "Pf03091" "51596" "ENSG00000112514; ENSG00000226492" "CUTA" "A2AB26; A2BEL4; hsa:51596; O60888; Q3B784; Q5JXM9; Q5SU05; Q9NYQ9" "" "" "0" "0" "1.084" "0.985" "1.119" "1.083" "1.055" "1.120" "1.015" "0.975" "0.727" "222.1" "240.7" "218.8" "248.6" "240.4" "234.3" "248.7" "225.3" "216.6" "161.5" "" "" "" "" "" "" "" "" "" "" "117.6" "133.4" "125.3" "114.5" "130.1" "130.3" "146.4" "123.0" "121.5" "161.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8372926252788997109" "False" "High" "IsMasterProtein" "Q5JTZ9" "Alanine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=AARS2 PE=1 SV=1" "0.000" "False" "14.591" "5" "4" "4" "4" "985" "107.3" "6.27" "8.73" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf01411, Pf07973" "57505" "ENSG00000124608" "AARS2" "A2RRN5; hsa:57505; Q5JTZ9; Q8N198; Q96D02; Q9ULF0" "Primary ovarian insufficiency" "Mitochondrial tRNA aminoacylation" "2" "0" "0.699" "0.689" "0.834" "0.780" "0.887" "0.651" "0.714" "0.604" "1.170" "118.2" "82.7" "81.4" "98.7" "92.2" "104.9" "77.0" "84.5" "71.5" "138.3" "" "" "" "" "" "" "" "" "" "" "62.6" "45.8" "46.6" "45.4" "49.9" "58.4" "45.3" "46.1" "40.1" "138.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5982176321518383" "False" "High" "IsMasterProtein" "Q92572" "AP-3 complex subunit sigma-1 OS=Homo sapiens OX=9606 GN=AP3S1 PE=1 SV=1" "0.000" "False" "14.574" "23" "4" "4" "4" "193" "21.7" "5.39" "8.83" "4" "cell organization and biogenesis;transport;signal transduction" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01217" "1176" "ENSG00000177879" "AP3S1" "hsa:1176; O00647; O00676; O00721; O00727; Q53XL4; Q6ICQ2; Q92572" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "1.220" "1.114" "0.975" "1.316" "0.925" "0.976" "0.849" "1.193" "2.469" "42.3" "51.7" "47.2" "41.3" "55.7" "39.2" "41.3" "35.9" "50.5" "104.6" "" "" "" "" "" "" "" "" "" "" "22.4" "28.6" "27.0" "19.0" "30.2" "21.8" "24.3" "19.6" "28.3" "104.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4527223765443096832" "False" "High" "IsMasterProtein" "O95785" "Protein Wiz OS=Homo sapiens OX=9606 GN=WIZ PE=1 SV=2" "0.000" "False" "14.563" "2" "4" "4" "4" "1651" "178.6" "6.86" "9.18" "4" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "58525" "ENSG00000011451" "WIZ" "B3KVH1; B7ZM82; hsa:58525; M0QY21; O95785; Q4G0E0; Q6P6B0; Q6ZN24; Q7LDY6; Q7LDZ1; Q96IG5; Q96SQ6; Q9BUR8; Q9NPT1" "" "" "0" "0" "1.322" "1.144" "1.233" "1.264" "1.109" "1.259" "1.213" "1.203" "1.269" "250.0" "330.6" "286.1" "308.3" "316.0" "277.3" "314.8" "303.4" "300.8" "317.2" "" "" "" "" "" "" "" "" "" "" "132.4" "183.3" "163.9" "142.0" "171.0" "154.2" "185.3" "165.6" "168.8" "317.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4243643898250283401" "False" "High" "IsMasterProtein" "Q9UI08" "Ena/VASP-like protein OS=Homo sapiens OX=9606 GN=EVL PE=1 SV=2" "0.000" "False" "14.552" "16" "6" "7" "5" "416" "44.6" "8.84" "14.71" "6" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00568, Pf08776" "51466" "ENSG00000196405" "EVL" "A8K105; B7Z3I5; hsa:51466; O95884; Q7Z522; Q8TBV1; Q9UF25; Q9UI08; Q9UIC2" "" "RHO GTPases Activate Formins; Generation of second messenger molecules; Signaling by ROBO receptors" "3" "0" "1.014" "1.002" "1.118" "1.111" "1.060" "1.097" "1.067" "1.203" "1.068" "271.5" "275.2" "272.0" "303.6" "301.5" "287.6" "297.8" "289.7" "326.5" "289.9" "" "" "" "" "" "" "" "" "" "" "143.7" "152.6" "155.7" "139.8" "163.1" "160.0" "175.3" "158.1" "183.2" "289.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2375435199137725135" "False" "High" "IsMasterProtein" "Q96MH2" "Protein HEXIM2 OS=Homo sapiens OX=9606 GN=HEXIM2 PE=1 SV=1" "0.000" "False" "14.521" "12" "4" "4" "4" "286" "32.4" "6.55" "12.55" "4" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf15313" "124790" "ENSG00000168517" "HEXIM2" "D3DX66; hsa:124790; Q96MH2" "" "" "0" "0" "0.954" "1.013" "1.062" "1.011" "0.973" "1.027" "1.083" "1.008" "0.582" "520.3" "496.3" "527.2" "552.7" "526.1" "506.1" "534.3" "563.5" "524.4" "302.9" "" "" "" "" "" "" "" "" "" "" "275.5" "275.1" "301.9" "254.5" "284.6" "281.5" "314.5" "307.6" "294.2" "302.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2887572586952269824" "False" "High" "IsMasterProtein" "Q9HCE1" "Helicase MOV-10 OS=Homo sapiens OX=9606 GN=MOV10 PE=1 SV=2" "0.000" "False" "14.505" "4" "5" "5" "5" "1003" "113.6" "8.82" "11.10" "5" "stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13086, Pf13087, Pf21632, Pf21633, Pf21634, Pf21635" "4343" "ENSG00000155363" "MOV10" "hsa:4343; Q5JR03; Q8TEF0; Q9BSY3; Q9BUJ9; Q9HCE1" "VEGFA-VEGFR2 signaling" "TP53 Regulates Metabolic Genes; MAPK6/MAPK4 signaling; Oxidative Stress Induced Senescence; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ca2+ pathway; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Nuclear events stimulated by ALK signaling in cancer; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "19" "0" "1.026" "0.994" "1.053" "1.051" "0.991" "0.978" "0.894" "0.927" "0.963" "444.1" "455.5" "441.5" "467.6" "466.8" "440.2" "434.4" "397.2" "411.5" "427.8" "" "" "" "" "" "" "" "" "" "" "235.2" "252.5" "252.8" "215.4" "252.6" "244.8" "255.7" "216.8" "230.9" "427.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6604733771635373365" "False" "High" "IsMasterProtein" "P84085" "ADP-ribosylation factor 5 OS=Homo sapiens OX=9606 GN=ARF5 PE=1 SV=2" "0.000" "False" "14.497" "21" "4" "7" "2" "180" "20.5" "6.79" "13.08" "4" "transport" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00025" "381" "ENSG00000004059" "ARF5" "hsa:381; P26437; P84085" "2q37 copy number variation syndrome" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "3" "1" "1.018" "0.924" "1.029" "0.989" "0.971" "0.978" "0.929" "0.944" "0.626" "488.8" "497.8" "451.9" "502.8" "483.5" "474.6" "478.2" "453.9" "461.6" "305.9" "" "" "" "" "" "" "" "" "" "" "258.8" "276.0" "258.8" "231.6" "261.6" "264.0" "281.4" "247.8" "259.0" "305.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2632668230264232030" "False" "High" "IsMasterProtein" "P61024" "Cyclin-dependent kinases regulatory subunit 1 OS=Homo sapiens OX=9606 GN=CKS1B PE=1 SV=1" "0.000" "False" "14.495" "28" "4" "6" "3" "79" "9.7" "8.94" "15.48" "4" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01111" "1163" "ENSG00000173207" "CKS1B" "hsa:1163; P33551; P61024" "Small cell lung cancer" "SCF(Skp2)-mediated degradation of p27/p21; Cyclin D associated events in G1" "3" "1" "0.927" "1.070" "0.901" "0.990" "1.028" "0.956" "0.981" "1.019" "0.930" "577.8" "535.6" "618.4" "520.6" "571.9" "593.8" "552.6" "566.9" "588.6" "537.3" "" "" "" "" "" "" "" "" "" "" "305.9" "296.9" "354.2" "239.7" "309.4" "330.3" "325.2" "309.4" "330.2" "537.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2904127799800100027" "False" "High" "IsMasterProtein" "Q8IYS1" "Xaa-Arg dipeptidase OS=Homo sapiens OX=9606 GN=PM20D2 PE=1 SV=2" "0.000" "False" "14.490" "9" "4" "5" "4" "436" "47.7" "5.85" "12.08" "4" "protein metabolism;other biological processes" "nucleus" "other molecular function" "Pf01546, Pf07687" "135293" "ENSG00000146281" "PM20D2" "B4DYJ2; hsa:135293; Q5T7J9; Q6MZV2; Q86XD9; Q8IYS1" "" "" "0" "0" "1.010" "0.971" "0.854" "1.058" "1.054" "1.124" "0.976" "1.074" "1.071" "131.4" "132.8" "127.6" "112.3" "139.0" "138.6" "147.8" "128.3" "141.1" "140.8" "" "" "" "" "" "" "" "" "" "" "69.6" "73.6" "73.1" "51.7" "75.2" "77.1" "87.0" "70.0" "79.2" "140.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5978569898189539548" "False" "High" "IsMasterProtein" "O75694" "Nuclear pore complex protein Nup155 OS=Homo sapiens OX=9606 GN=NUP155 PE=1 SV=1" "0.000" "False" "14.469" "3" "4" "4" "4" "1391" "155.1" "6.16" "12.13" "4" "cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf08801" "9631" "ENSG00000113569" "NUP155" "hsa:9631; O75694; Q9UBE9; Q9UFL5" "" "ISG15 antiviral mechanism; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "29" "0" "1.142" "1.131" "0.982" "0.919" "1.037" "0.964" "1.011" "0.985" "1.067" "324.5" "370.5" "367.1" "318.7" "298.3" "336.5" "312.9" "328.1" "319.6" "346.2" "" "" "" "" "" "" "" "" "" "" "171.8" "205.4" "210.2" "146.8" "161.4" "187.2" "184.2" "179.1" "179.3" "346.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2546736599525709996" "False" "High" "IsMasterProtein" "Q8N1G2" "Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 OS=Homo sapiens OX=9606 GN=CMTR1 PE=1 SV=1" "0.000" "False" "14.462" "5" "4" "6" "4" "835" "95.3" "7.05" "8.64" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01585, Pf01728" "23070" "ENSG00000137200" "CMTR1" "A8K949; hsa:23070; Q14670; Q8N1G2; Q96FJ9" "" "" "0" "0" "1.089" "0.976" "1.091" "1.253" "1.114" "1.203" "0.981" "1.518" "1.685" "379.5" "413.2" "370.4" "413.9" "475.4" "422.9" "456.5" "372.4" "576.0" "639.5" "" "" "" "" "" "" "" "" "" "" "200.9" "229.1" "212.1" "190.6" "257.2" "235.2" "268.7" "203.3" "323.1" "639.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8218333417811039911" "False" "High" "IsMasterProtein" "Q9H299" "SH3 domain-binding glutamic acid-rich-like protein 3 OS=Homo sapiens OX=9606 GN=SH3BGRL3 PE=1 SV=1" "0.000" "False" "14.461" "47" "4" "14" "4" "93" "10.4" "4.93" "42.75" "4" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf04908" "83442" "ENSG00000142669" "SH3BGRL3" "hsa:83442; Q5T122; Q9H299" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.998" "1.012" "0.933" "1.064" "0.912" "0.955" "0.975" "0.974" "0.530" "1782.3" "1778.2" "1803.4" "1663.7" "1897.2" "1625.3" "1701.9" "1738.2" "1735.7" "945.3" "" "" "" "" "" "" "" "" "" "" "943.7" "985.9" "1032.8" "766.2" "1026.4" "904.1" "1001.6" "948.8" "973.7" "945.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1377635877244790923" "False" "High" "IsMasterProtein" "P36873" "Serine/threonine-protein phosphatase PP1-gamma catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CC PE=1 SV=1" "0.000" "False" "14.449" "9" "3" "5" "2" "323" "37.0" "6.54" "14.83" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00149, Pf16891" "5501" "ENSG00000186298" "PPP1CC" "hsa:5501; P36873" "Common pathways underlying drug addiction; Focal adhesion; Hippo-Merlin signaling dysregulation; Neuroinflammation and glutamatergic signaling" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Triglyceride catabolism; Circadian Clock; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Downregulation of TGF-beta receptor signaling; Maturation of hRSV A proteins" "17" "0" "1.030" "0.985" "1.040" "1.071" "0.986" "1.206" "1.046" "1.009" "0.732" "512.3" "527.9" "504.7" "533.0" "549.0" "505.2" "618.0" "536.0" "516.7" "375.1" "" "" "" "" "" "" "" "" "" "" "271.3" "292.7" "289.0" "245.5" "297.0" "281.0" "363.7" "292.6" "289.9" "375.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1749149961980637251" "False" "High" "IsMasterProtein" "P27361" "Mitogen-activated protein kinase 3 OS=Homo sapiens OX=9606 GN=MAPK3 PE=1 SV=4" "0.000" "False" "14.422" "11" "5" "6" "5" "379" "43.1" "6.74" "15.90" "5" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069" "5595" "ENSG00000102882" "MAPK3" "A8CZ58; B0LPG3; hsa:5595; P27361; Q8NHX1" "IL-5 signaling pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; PDGF pathway; Polycystic kidney disease pathway; S1P receptor signal transduction; Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; IL-3 signaling pathway; TCA cycle nutrient use and invasiveness of ovarian cancer; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; MFAP5-mediated ovarian cancer cell motility and invasiveness; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; Hypothesized pathways in pathogenesis of cardiovascular disease; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; BMP signaling in eyelid development; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; Prion disease pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Neovascularization processes; Non-genomic actions of 1,25 dihydroxyvitamin D3; Bile acids synthesis and enterohepatic circulation ; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Regulatory circuits of the STAT3 signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; TGF-beta receptor signaling in skeletal dysplasias; Kisspeptin/kisspeptin receptor system in the ovary; CAMKK2 pathway; Disruption of postsynaptic signaling by CNV; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; 7q11.23 copy number variation syndrome; 16p11.2 proximal deletion syndrome; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; 2q11.2 copy number variation syndrome; Comprehensive IL-17A signaling; Genetic causes of porto-sinusoidal vascular disease; Acute myeloid leukemia; 8p23.1 copy number variation syndrome; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; Osteoarthritic chondrocyte hypertrophy; NPHP1 deletion syndrome; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; GNAQ pathways in port-wine stain; TGF-beta receptor signaling; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling; Toll-like receptor signaling pathway" "Oxidative Stress Induced Senescence; Oncogene Induced Senescence; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Regulation of PTEN gene transcription; ISG15 antiviral mechanism; Signal transduction by L1; Suppression of apoptosis; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCGR3A-mediated phagocytosis; NPAS4 regulates expression of target genes; RHO GTPases Activate WASPs and WAVEs; Regulation of HSF1-mediated heat shock response; Signaling by BRAF and RAF1 fusions; Thrombin signalling through proteinase activated receptors (PARs); Signaling by NODAL; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Interferon gamma signaling; Senescence-Associated Secretory Phenotype (SASP); Growth hormone receptor signaling; Regulation of the apoptosome activity; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; NCAM signaling for neurite out-growth; Downregulation of SMAD2/3:SMAD4 transcriptional activity; RUNX2 regulates osteoblast differentiation; RSK activation; Spry regulation of FGF signaling; MAPK3 (ERK1) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; IFNG signaling activates MAPKs; RNA Polymerase I Promoter Opening; Signaling by Activin; Activation of the AP-1 family of transcription factors; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Signal attenuation; Gastrin-CREB signalling pathway via PKC and MAPK; ESR-mediated signaling; Negative feedback regulation of MAPK pathway; Advanced glycosylation endproduct receptor signaling; RHO GTPases Activate NADPH Oxidases; Nuclear events stimulated by ALK signaling in cancer; ERKs are inactivated; Signaling by MAP2K mutants" "178" "0" "0.918" "0.973" "0.858" "0.914" "1.016" "0.852" "0.755" "0.771" "1.021" "298.7" "274.1" "290.8" "256.4" "272.9" "303.5" "254.5" "225.7" "230.2" "305.1" "" "" "" "" "" "" "" "" "" "" "158.2" "152.0" "166.5" "118.1" "147.7" "168.8" "149.8" "123.2" "129.1" "305.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1150602487247342071" "False" "High" "IsMasterProtein" "Q92890" "Ubiquitin recognition factor in ER-associated degradation protein 1 OS=Homo sapiens OX=9606 GN=UFD1 PE=1 SV=3" "0.000" "False" "14.397" "8" "4" "5" "4" "307" "34.5" "6.70" "16.44" "4" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf03152" "7353" "ENSG00000070010" "UFD1" "A8MW31; hsa:7353; Q92890; Q9Y5N0" "22q11.2 copy number variation syndrome" "Ub-specific processing proteases; Neddylation; KEAP1-NFE2L2 pathway; Translesion Synthesis by POLH" "5" "0" "1.031" "1.182" "0.972" "1.090" "1.016" "1.070" "1.083" "1.134" "0.606" "485.4" "500.5" "573.7" "471.9" "529.2" "493.2" "519.5" "525.9" "550.7" "294.0" "" "" "" "" "" "" "" "" "" "" "257.0" "277.5" "328.6" "217.3" "286.3" "274.3" "305.8" "287.1" "308.9" "294.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5945011317712517661" "False" "High" "IsMasterProtein" "P25787" "Proteasome subunit alpha type-2 OS=Homo sapiens OX=9606 GN=PSMA2 PE=1 SV=2" "0.000" "False" "14.393" "14" "3" "5" "3" "234" "25.9" "7.43" "14.46" "3" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00227, Pf10584" "5683" "ENSG00000106588" "PSMA2" "hsa:5683; P25787; Q6ICS6; Q9BU45" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; Downstream TCR signaling; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "0.760" "0.895" "0.967" "0.723" "0.953" "0.866" "1.080" "0.844" "0.431" "169.6" "128.9" "151.7" "164.0" "122.6" "161.7" "146.9" "183.3" "143.1" "73.1" "" "" "" "" "" "" "" "" "" "" "89.8" "71.5" "86.9" "75.5" "66.3" "89.9" "86.4" "100.0" "80.3" "73.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5089087001200962096" "False" "High" "IsMasterProtein" "Q12802" "A-kinase anchor protein 13 OS=Homo sapiens OX=9606 GN=AKAP13 PE=1 SV=2" "0.000" "False" "14.373" "1" "4" "4" "4" "2813" "307.4" "5.24" "11.68" "4" "developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00621, Pf10522" "11214" "ENSG00000170776" "AKAP13" "hsa:11214; Q12802; Q14572; Q59FP6; Q86W90; Q8WXQ6; Q96JP6; Q96P79; Q9Y5T0; Q9Y5T6" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; G protein signaling pathways" "RHOC GTPase cycle; RHOA GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOB GTPase cycle" "8" "0" "0.931" "0.954" "1.140" "1.081" "1.072" "1.211" "1.284" "1.425" "0.876" "399.0" "371.6" "380.7" "455.0" "431.2" "427.7" "483.3" "512.3" "568.6" "349.4" "" "" "" "" "" "" "" "" "" "" "211.3" "206.0" "218.0" "209.6" "233.3" "237.9" "284.4" "279.6" "319.0" "349.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5723353511819689268" "False" "High" "IsMasterProtein" "Q92947" "Glutaryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=GCDH PE=1 SV=1" "0.000" "False" "14.342" "9" "4" "5" "4" "438" "48.1" "8.06" "10.61" "4" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00441, Pf02770, Pf02771" "2639" "ENSG00000105607" "GCDH" "A8K2Z2; O14719; Q92947" "Fatty acid beta-oxidation; Tryptophan metabolism" "Lysine catabolism" "3" "0" "1.036" "1.058" "1.036" "0.875" "0.864" "0.802" "0.886" "0.836" "0.684" "362.6" "375.6" "383.7" "375.8" "317.2" "313.5" "290.7" "321.2" "303.2" "248.1" "" "" "" "" "" "" "" "" "" "" "192.0" "208.3" "219.7" "173.0" "171.6" "174.4" "171.1" "175.3" "170.1" "248.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5643527966773386320" "False" "High" "IsMasterProtein" "Q8IWZ8" "SURP and G-patch domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SUGP1 PE=1 SV=2" "0.000" "False" "14.326" "7" "3" "3" "3" "645" "72.4" "7.61" "9.44" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf01585, Pf01805" "57794" "ENSG00000105705" "SUGP1" "hsa:57794; O60378; Q6P3X9; Q8IWZ8; Q8TCQ4; Q8WWT4; Q8WWT5; Q9NTG3" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.109" "0.834" "1.010" "0.919" "0.930" "1.342" "1.021" "1.075" "1.335" "31.3" "34.7" "26.1" "31.6" "28.7" "29.1" "42.0" "31.9" "33.6" "41.7" "" "" "" "" "" "" "" "" "" "" "16.6" "19.2" "14.9" "14.6" "15.6" "16.2" "24.7" "17.4" "18.9" "41.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1080022240978719765" "False" "High" "IsMasterProtein" "P49721" "Proteasome subunit beta type-2 OS=Homo sapiens OX=9606 GN=PSMB2 PE=1 SV=1" "0.000" "False" "14.322" "16" "3" "7" "3" "201" "22.8" "7.02" "19.95" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00227" "5690" "ENSG00000126067" "PSMB2" "D3DPS0; hsa:5690; P31145; P49721; Q9BWZ9" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "0.956" "0.932" "0.955" "0.975" "1.033" "1.081" "1.072" "0.894" "0.629" "874.3" "835.6" "814.9" "834.6" "852.0" "903.1" "945.2" "937.3" "782.0" "549.5" "" "" "" "" "" "" "" "" "" "" "462.9" "463.3" "466.7" "384.4" "461.0" "502.4" "556.3" "511.6" "438.7" "549.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8833094404749326966" "False" "High" "IsMasterProtein" "Q9Y285" "Phenylalanine--tRNA ligase alpha subunit OS=Homo sapiens OX=9606 GN=FARSA PE=1 SV=3" "0.000" "False" "14.320" "8" "3" "4" "3" "508" "57.5" "7.80" "5.66" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01409, Pf18552, Pf18553, Pf18554" "2193" "ENSG00000179115" "FARSA" "B4E363; hsa:2193; Q9NSD8; Q9Y285; Q9Y4W8" "" "Cytosolic tRNA aminoacylation" "1" "0" "1.024" "0.852" "1.133" "1.181" "1.079" "0.947" "0.506" "0.804" "4.953" "137.7" "141.1" "117.3" "156.0" "162.7" "148.7" "130.4" "69.7" "110.8" "682.1" "" "" "" "" "" "" "" "" "" "" "72.9" "78.2" "67.2" "71.9" "88.0" "82.7" "76.8" "38.0" "62.1" "682.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2821733550000515702" "False" "High" "IsMasterProtein" "Q9NX46" "ADP-ribosylhydrolase ARH3 OS=Homo sapiens OX=9606 GN=ADPRS PE=1 SV=1" "0.000" "False" "14.311" "15" "4" "5" "4" "363" "38.9" "5.07" "6.97" "4" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf03747" "54936" "ENSG00000116863" "ADPRS" "hsa:54936; Q53G94; Q6IAB8; Q9BY47; Q9NX46" "" "POLB-Dependent Long Patch Base Excision Repair" "1" "0" "1.050" "0.973" "0.956" "1.087" "0.982" "0.735" "0.854" "0.904" "0.961" "131.0" "137.6" "127.5" "125.3" "142.4" "128.7" "96.2" "111.9" "118.4" "125.9" "" "" "" "" "" "" "" "" "" "" "69.4" "76.3" "73.0" "57.7" "77.0" "71.6" "56.6" "61.1" "66.4" "125.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6816418598839755867" "False" "High" "IsMasterProtein" "Q9NXC5" "GATOR2 complex protein MIOS OS=Homo sapiens OX=9606 GN=MIOS PE=1 SV=2" "0.000" "False" "14.306" "6" "4" "4" "4" "875" "98.5" "6.73" "8.59" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf17034, Pf21719, Pf21720" "54468" "ENSG00000164654" "MIOS" "B2RTV6; hsa:54468; O75216; Q7L551; Q9H092; Q9NXC5" "" "Amino acids regulate mTORC1" "1" "0" "1.011" "0.925" "1.027" "1.160" "0.961" "1.065" "0.959" "0.963" "0.790" "153.8" "155.6" "142.3" "158.0" "178.4" "147.9" "163.9" "147.5" "148.1" "121.5" "" "" "" "" "" "" "" "" "" "" "81.5" "86.2" "81.5" "72.7" "96.5" "82.2" "96.4" "80.5" "83.1" "121.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7973813700341614243" "False" "High" "IsMasterProtein" "Q96SB4" "SRSF protein kinase 1 OS=Homo sapiens OX=9606 GN=SRPK1 PE=1 SV=2" "0.000" "False" "14.297" "9" "6" "7" "6" "655" "74.3" "6.16" "14.85" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6732" "ENSG00000096063" "SRPK1" "B4DS61; hsa:6732; Q12890; Q5R364; Q5R365; Q8IY12; Q96SB4" "VEGFA-VEGFR2 signaling; mRNA processing" "Replacement of protamines by nucleosomes in the male pronucleus; Maturation of nucleoprotein" "4" "0" "1.015" "1.028" "1.051" "1.103" "1.140" "1.064" "0.966" "1.070" "1.681" "634.8" "644.5" "652.6" "667.4" "700.1" "723.9" "675.2" "612.9" "679.1" "1067.1" "" "" "" "" "" "" "" "" "" "" "336.1" "357.3" "373.7" "307.4" "378.8" "402.7" "397.4" "334.5" "381.0" "1067.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7525494529212049263" "False" "High" "IsMasterProtein" "O43149" "Zinc finger ZZ-type and EF-hand domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZZEF1 PE=1 SV=6" "0.000" "False" "14.286" "2" "5" "5" "5" "2961" "330.9" "5.95" "13.56" "5" "cell organization and biogenesis" "" "other molecular function" "Pf00569, Pf03256" "23140" "ENSG00000074755" "ZZEF1" "A7MBM5; hsa:23140; O43149; Q6NXG0; Q6ZRA1; Q6ZSF4; Q9NVB9" "" "" "0" "0" "0.982" "0.973" "0.987" "1.006" "1.021" "1.011" "0.980" "0.999" "1.186" "602.6" "591.6" "586.2" "594.7" "606.2" "615.5" "609.5" "590.3" "601.9" "714.5" "" "" "" "" "" "" "" "" "" "" "319.1" "328.0" "335.7" "273.9" "328.0" "342.4" "358.7" "322.2" "337.6" "714.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3098195104215073585" "False" "High" "IsMasterProtein" "P23919" "Thymidylate kinase OS=Homo sapiens OX=9606 GN=DTYMK PE=1 SV=4" "0.000" "False" "14.280" "16" "4" "9" "4" "212" "23.8" "8.27" "23.40" "4" "other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf02223" "1841" "ENSG00000168393" "DTYMK" "B7ZW70; hsa:1841; P23919; Q6FGX1; Q9BUX4" "Pyrimidine metabolism; 2q37 copy number variation syndrome" "Interconversion of nucleotide di- and triphosphates" "3" "0" "0.973" "1.017" "0.892" "0.977" "1.005" "0.833" "0.947" "0.892" "0.563" "514.4" "500.3" "523.2" "458.6" "502.4" "517.1" "428.3" "486.9" "459.0" "289.6" "" "" "" "" "" "" "" "" "" "" "272.4" "277.4" "299.7" "211.2" "271.8" "287.6" "252.1" "265.8" "257.5" "289.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4886602285452216196" "False" "High" "IsMasterProtein" "Q92696" "Geranylgeranyl transferase type-2 subunit alpha OS=Homo sapiens OX=9606 GN=RABGGTA PE=1 SV=2" "0.000" "False" "14.273" "9" "6" "6" "6" "567" "65.0" "5.67" "14.88" "6" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00560, Pf01239, Pf07711" "5875" "ENSG00000100949; ENSG00000285193" "RABGGTA" "A8K5N2; D3DS69; hsa:5875; Q92696" "" "RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "2" "0" "1.117" "1.074" "1.086" "1.047" "1.071" "1.029" "1.073" "0.977" "0.680" "207.7" "232.0" "223.0" "225.6" "217.4" "222.4" "213.7" "222.9" "202.9" "141.3" "" "" "" "" "" "" "" "" "" "" "110.0" "128.6" "127.7" "103.9" "117.6" "123.7" "125.8" "121.7" "113.8" "141.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8013273140133158732" "False" "High" "IsMasterProtein" "Q9H3P7" "Golgi resident protein GCP60 OS=Homo sapiens OX=9606 GN=ACBD3 PE=1 SV=4" "0.000" "False" "14.259" "9" "5" "5" "5" "528" "60.6" "5.06" "12.25" "5" "other metabolic processes" "other membranes;mitochondrion;ER/Golgi" "other molecular function" "Pf00887, Pf13897" "64746" "ENSG00000182827" "ACBD3" "B2RB29; hsa:64746; Q5VTJ0; Q6P9F1; Q8IZC5; Q8N4D6; Q9H3P7; Q9H6U3" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "1.077" "1.068" "1.070" "1.147" "1.148" "1.388" "1.371" "1.462" "2.185" "360.6" "388.5" "385.0" "386.0" "413.8" "414.0" "500.6" "494.4" "527.2" "787.9" "" "" "" "" "" "" "" "" "" "" "190.9" "215.4" "220.5" "177.8" "223.9" "230.3" "294.6" "269.9" "295.8" "787.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7748454017014718970" "False" "High" "IsMasterProtein" "Q9Y5Y0" "Heme transporter FLVCR1 OS=Homo sapiens OX=9606 GN=FLVCR1 PE=1 SV=1" "0.000" "False" "14.252" "6" "2" "2" "2" "555" "59.8" "5.97" "8.36" "2" "other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;mitochondrion" "transporter activity;other molecular function" "" "28982" "ENSG00000162769" "FLVCR1" "hsa:28982; Q1HE16; Q86XY9; Q9NVR9; Q9Y5Y0" "" "" "0" "0" "1.046" "1.146" "1.074" "0.956" "0.937" "0.945" "0.902" "0.810" "0.614" "147.1" "153.9" "168.6" "158.1" "140.7" "137.8" "139.0" "132.6" "119.2" "90.3" "" "" "" "" "" "" "" "" "" "" "77.9" "85.3" "96.6" "72.8" "76.1" "76.7" "81.8" "72.4" "66.9" "90.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6175620915795625691" "False" "High" "IsMasterProtein" "Q13151" "Heterogeneous nuclear ribonucleoprotein A0 OS=Homo sapiens OX=9606 GN=HNRNPA0 PE=1 SV=1" "0.000" "False" "14.237" "16" "5" "17" "4" "305" "30.8" "9.29" "34.36" "5" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "10949" "ENSG00000177733" "HNRNPA0" "hsa:10949; Q13151; Q6IB18" "" "" "0" "0" "1.001" "1.153" "1.183" "1.211" "1.039" "2.367" "2.082" "2.228" "6.283" "177.8" "177.9" "204.9" "210.4" "215.3" "184.8" "420.8" "370.1" "396.1" "1117.1" "" "" "" "" "" "" "" "" "" "" "94.1" "98.6" "117.4" "96.9" "116.5" "102.8" "247.7" "202.0" "222.2" "1117.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5444198170657218689" "False" "High" "IsMasterProtein" "O14508" "Suppressor of cytokine signaling 2 OS=Homo sapiens OX=9606 GN=SOCS2 PE=1 SV=1" "0.000" "False" "14.225" "17" "4" "4" "4" "198" "22.2" "8.69" "14.29" "4" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf07525" "8835" "ENSG00000120833" "SOCS2" "A8K3D1; hsa:8835; O14508; O14542; O95102; Q9UKS5" "Leptin signaling pathway; Prolactin signaling pathway; Ectoderm differentiation; Leptin-insulin signaling overlap; JAK-STAT signaling in the regulation of beta cells" "Neddylation; Interleukin-7 signaling; Negative regulation of FLT3; Growth hormone receptor signaling" "9" "0" "1.017" "0.957" "0.948" "1.024" "1.056" "1.025" "1.016" "1.042" "0.698" "1373.8" "1397.0" "1314.7" "1302.6" "1406.4" "1450.2" "1408.2" "1395.6" "1431.0" "958.5" "" "" "" "" "" "" "" "" "" "" "727.4" "774.5" "752.9" "599.9" "760.9" "806.7" "828.8" "761.8" "802.7" "958.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3988284594388072596" "False" "High" "IsMasterProtein" "Q92974" "Rho guanine nucleotide exchange factor 2 OS=Homo sapiens OX=9606 GN=ARHGEF2 PE=1 SV=4" "0.000" "False" "14.219" "4" "4" "4" "4" "986" "111.5" "7.27" "13.74" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00621, Pf17838" "9181" "ENSG00000116584" "ARHGEF2" "D3DVA6; hsa:9181; O75142; Q15079; Q5VY92; Q8TDA3; Q8WUG4; Q92974; Q9H023" "Pathogenic Escherichia coli infection" "RHOA GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOB GTPase cycle" "5" "0" "1.050" "0.991" "1.384" "1.184" "1.201" "1.530" "1.353" "1.682" "4.777" "125.9" "132.2" "124.8" "174.2" "149.0" "151.2" "192.6" "170.3" "211.7" "601.3" "" "" "" "" "" "" "" "" "" "" "66.7" "73.3" "71.5" "80.2" "80.6" "84.1" "113.4" "93.0" "118.8" "601.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3187719389386559931" "False" "High" "IsMasterProtein" "Q9Y2V2" "Calcium-regulated heat-stable protein 1 OS=Homo sapiens OX=9606 GN=CARHSP1 PE=1 SV=2" "0.000" "False" "14.205" "24" "3" "5" "3" "147" "15.9" "8.21" "9.77" "3" "signal transduction;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00313" "23589" "ENSG00000153048" "CARHSP1" "B2R4C3; D3DUF5; hsa:23589; Q2YDX5; Q9BQ53; Q9Y2V2" "" "" "0" "0" "0.969" "0.930" "1.004" "0.894" "0.865" "1.079" "0.887" "0.897" "0.830" "64.2" "62.2" "59.7" "64.5" "57.4" "55.5" "69.3" "57.0" "57.6" "53.3" "" "" "" "" "" "" "" "" "" "" "34.0" "34.5" "34.2" "29.7" "31.0" "30.9" "40.8" "31.1" "32.3" "53.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1014508030414011044" "False" "High" "IsMasterProtein" "P62899" "Large ribosomal subunit protein eL31 OS=Homo sapiens OX=9606 GN=RPL31 PE=1 SV=1" "0.000" "False" "14.159" "28" "4" "5" "4" "125" "14.5" "10.54" "12.06" "4" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01198" "6160" "ENSG00000071082" "RPL31" "B7Z4K2; D3DVJ4; hsa:6160; P12947; P62899; Q53SQ5; Q6IRZ0; Q6LBJ6" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.104" "1.137" "1.515" "1.227" "1.310" "1.335" "1.176" "1.296" "0.837" "214.2" "236.6" "243.6" "324.6" "262.9" "280.6" "285.9" "251.9" "277.6" "179.3" "" "" "" "" "" "" "" "" "" "" "113.4" "131.2" "139.5" "149.5" "142.2" "156.1" "168.3" "137.5" "155.7" "179.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5216931438576770944" "False" "High" "IsMasterProtein" "Q9UK76" "Jupiter microtubule associated homolog 1 OS=Homo sapiens OX=9606 GN=JPT1 PE=1 SV=3" "0.000" "False" "14.149" "20" "3" "5" "3" "154" "16.0" "5.60" "9.98" "3" "" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf17054" "51155" "ENSG00000189159" "JPT1" "B2R6K3; hsa:51155; Q53FG7; Q7Z2D2; Q7Z2F0; Q9UK76" "" "" "0" "0" "1.105" "1.012" "0.907" "0.969" "0.898" "0.895" "1.008" "0.941" "0.471" "223.4" "246.7" "226.0" "202.5" "216.5" "200.6" "200.0" "225.2" "210.3" "105.1" "" "" "" "" "" "" "" "" "" "" "118.3" "136.8" "129.4" "93.3" "117.1" "111.6" "117.7" "122.9" "118.0" "105.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4299442073717893558" "False" "High" "IsMasterProtein" "Q9Y6A4" "Cilia- and flagella-associated protein 20 OS=Homo sapiens OX=9606 GN=CFAP20 PE=1 SV=1" "0.000" "False" "14.142" "21" "4" "4" "4" "193" "22.8" "9.76" "11.48" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "" "Pf05018" "29105" "ENSG00000070761" "CFAP20" "hsa:29105; Q9Y6A4" "" "" "0" "0" "1.178" "0.992" "1.105" "1.168" "1.292" "1.325" "1.055" "1.387" "2.090" "296.6" "349.5" "294.3" "327.8" "346.3" "383.1" "392.9" "312.9" "411.4" "620.0" "" "" "" "" "" "" "" "" "" "" "157.1" "193.8" "168.6" "150.9" "187.4" "213.1" "231.2" "170.8" "230.8" "620.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1641780535886565556" "False" "High" "IsMasterProtein" "Q7L1T6" "Cytochrome b5 reductase 4 OS=Homo sapiens OX=9606 GN=CYB5R4 PE=1 SV=1" "0.000" "False" "14.136" "9" "4" "4" "4" "521" "59.4" "7.72" "12.38" "4" "cell-cell signaling;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00173, Pf00175, Pf00970, Pf04969" "51167" "ENSG00000065615" "CYB5R4" "B1AEM2; hsa:51167; Q5TGI9; Q7L1T6; Q9NUE4; Q9UHI9" "Oxidation by cytochrome P450" "Erythrocytes take up carbon dioxide and release oxygen" "2" "0" "1.112" "1.002" "0.923" "1.022" "1.084" "0.770" "0.689" "0.735" "0.879" "229.0" "254.8" "229.4" "211.5" "234.0" "248.4" "176.3" "157.8" "168.3" "201.2" "" "" "" "" "" "" "" "" "" "" "121.3" "141.3" "131.4" "97.4" "126.6" "138.1" "103.8" "86.1" "94.4" "201.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8735053905858643513" "False" "High" "IsMasterProtein" "Q16401" "26S proteasome non-ATPase regulatory subunit 5 OS=Homo sapiens OX=9606 GN=PSMD5 PE=1 SV=3" "0.000" "False" "14.119" "9" "5" "7" "5" "504" "56.2" "5.48" "18.71" "5" "cell organization and biogenesis" "cytosol;nucleus;other cell component" "" "Pf10508" "5711" "ENSG00000095261" "PSMD5" "B4DZM8; hsa:5711; Q15045; Q16401; Q4VXG8" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of expression of SLITs and ROBOs; ER-Phagosome pathway; Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "61" "0" "1.114" "1.068" "1.377" "1.415" "1.207" "1.092" "1.161" "0.979" "1.266" "57.2" "63.7" "61.1" "78.7" "81.0" "69.0" "62.4" "66.4" "56.0" "72.4" "" "" "" "" "" "" "" "" "" "" "30.3" "35.3" "35.0" "36.3" "43.8" "38.4" "36.7" "36.2" "31.4" "72.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "783704005019212775" "False" "High" "IsMasterProtein" "Q8IZ21" "Phosphatase and actin regulator 4 OS=Homo sapiens OX=9606 GN=PHACTR4 PE=1 SV=1" "0.000" "False" "14.113" "6" "4" "4" "4" "702" "78.2" "6.62" "10.19" "4" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf02755" "65979" "ENSG00000204138" "PHACTR4" "A2APK6; B9ZVW0; D3DPM3; hsa:65979; Q68DD4; Q6NUN6; Q8IZ21; Q8N384; Q9H395; Q9H6X0; Q9H8W6" "" "" "0" "0" "0.934" "1.003" "1.059" "1.013" "0.916" "0.930" "0.939" "0.915" "0.576" "454.9" "425.0" "456.2" "481.7" "460.8" "416.9" "422.9" "427.1" "416.4" "262.1" "" "" "" "" "" "" "" "" "" "" "240.9" "235.6" "261.3" "221.8" "249.3" "231.9" "248.9" "233.2" "233.6" "262.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7001709167677346758" "False" "High" "IsMasterProtein" "Q9Y305" "Acyl-coenzyme A thioesterase 9, mitochondrial OS=Homo sapiens OX=9606 GN=ACOT9 PE=1 SV=2" "0.000" "False" "14.107" "10" "5" "5" "5" "439" "49.9" "8.60" "12.15" "5" "other metabolic processes" "mitochondrion" "other molecular function" "" "23597" "ENSG00000123130" "ACOT9" "B3KNC9; B7ZM94; hsa:23597; Q9Y305" "VEGFA-VEGFR2 signaling" "Mitochondrial Fatty Acid Beta-Oxidation" "2" "0" "1.064" "1.031" "1.025" "0.992" "1.078" "0.886" "0.876" "0.822" "0.622" "329.7" "350.7" "339.8" "337.9" "327.0" "355.5" "292.0" "288.7" "271.1" "205.1" "" "" "" "" "" "" "" "" "" "" "174.6" "194.5" "194.6" "155.6" "176.9" "197.7" "171.9" "157.6" "152.1" "205.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3785691322693480288" "False" "High" "IsMasterProtein" "O95834" "Echinoderm microtubule-associated protein-like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=1" "0.000" "False" "14.105" "7" "5" "5" "5" "649" "70.6" "6.32" "14.86" "5" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf03451" "24139" "ENSG00000125746" "EML2" "B7Z3I2; B7Z3Q9; hsa:24139; K7ERL7; O95834; Q59EN8; Q8N5A2; Q9UG50" "" "" "0" "0" "1.027" "0.964" "1.036" "0.979" "0.990" "0.990" "0.932" "0.963" "0.697" "320.1" "328.6" "308.7" "331.6" "313.5" "317.0" "316.7" "298.2" "308.2" "223.0" "" "" "" "" "" "" "" "" "" "" "169.5" "182.2" "176.8" "152.7" "169.6" "176.3" "186.4" "162.8" "172.9" "223.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2222501069186758979" "False" "High" "IsMasterProtein" "Q86W42" "THO complex subunit 6 homolog OS=Homo sapiens OX=9606 GN=THOC6 PE=1 SV=1" "0.000" "False" "14.064" "7" "2" "3" "2" "341" "37.5" "7.43" "9.38" "2" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00400" "79228" "ENSG00000131652" "THOC6" "B2RA85; hsa:79228; Q86W42; Q8NBR1; Q9BTV9" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "0.984" "1.000" "1.149" "1.068" "1.038" "1.173" "0.937" "0.986" "0.791" "266.3" "262.1" "266.3" "305.8" "284.4" "276.5" "312.4" "249.5" "262.7" "210.6" "" "" "" "" "" "" "" "" "" "" "141.0" "145.3" "152.5" "140.8" "153.9" "153.8" "183.9" "136.2" "147.3" "210.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4989435524198560061" "False" "High" "IsMasterProtein" "P48506" "Glutamate--cysteine ligase catalytic subunit OS=Homo sapiens OX=9606 GN=GCLC PE=1 SV=2" "0.000" "False" "14.053" "7" "4" "5" "3" "637" "72.7" "6.09" "11.48" "4" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf03074" "2729" "ENSG00000001084" "GCLC" "hsa:2729; P48506; Q14399" "Glutathione metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Aryl hydrocarbon receptor pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; One-carbon metabolism and related pathways; Oxidative stress response; Ferroptosis; NRF2-ARE regulation; Vitamin D-sensitive calcium signaling in depression; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway" "Glutathione synthesis and recycling; NFE2L2 regulating anti-oxidant/detoxification enzymes; Defective GCLC causes HAGGSD" "17" "0" "1.125" "0.972" "1.127" "1.051" "1.016" "0.974" "0.784" "0.937" "1.025" "320.7" "360.7" "311.7" "361.4" "336.9" "325.9" "312.5" "251.6" "300.6" "328.8" "" "" "" "" "" "" "" "" "" "" "169.8" "200.0" "178.5" "166.4" "182.3" "181.3" "183.9" "137.3" "168.6" "328.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4044629129436372468" "False" "High" "IsMasterProtein" "Q14160" "Protein scribble homolog OS=Homo sapiens OX=9606 GN=SCRIB PE=1 SV=5" "0.000" "False" "14.045" "2" "4" "6" "4" "1630" "174.8" "5.07" "18.34" "4" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00560, Pf00595, Pf13855" "23513" "ENSG00000180900; ENSG00000274287" "SCRIB" "hsa:23513; Q14160; Q6P496; Q7Z5D1; Q8WWV8; Q96C69; Q96GG1" "Thyroid stimulating hormone (TSH) signaling pathway; Complement system in neuronal development and plasticity" "CDC42 GTPase cycle; RHOQ GTPase cycle; Asymmetric localization of PCP proteins; RND2 GTPase cycle; RHOJ GTPase cycle; RND3 GTPase cycle" "8" "0" "1.070" "1.083" "1.200" "1.125" "1.080" "1.709" "1.654" "1.580" "1.700" "200.9" "214.9" "217.6" "241.0" "226.0" "217.0" "343.2" "332.2" "317.3" "341.6" "" "" "" "" "" "" "" "" "" "" "106.4" "119.1" "124.6" "111.0" "122.3" "120.7" "202.0" "181.3" "178.0" "341.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3553931004733427798" "False" "High" "IsMasterProtein" "P62306" "Small nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=SNRPF PE=1 SV=1" "0.000" "False" "14.041" "24" "3" "8" "3" "86" "9.7" "4.67" "19.92" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "6636" "ENSG00000139343" "SNRPF" "A2VCR2; B2R498; hsa:6636; P62306; Q15356; Q6IBQ1; Q6P4I0" "mRNA processing" "snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "8" "0" "0.911" "0.950" "1.065" "1.005" "1.000" "1.048" "1.248" "1.020" "0.683" "148.1" "134.9" "140.7" "157.8" "148.8" "148.1" "155.2" "184.8" "151.1" "101.1" "" "" "" "" "" "" "" "" "" "" "78.4" "74.8" "80.6" "72.7" "80.5" "82.4" "91.4" "100.9" "84.8" "101.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6162368025994279371" "False" "High" "IsMasterProtein" "Q13395" "Probable methyltransferase TARBP1 OS=Homo sapiens OX=9606 GN=TARBP1 PE=1 SV=1" "0.000" "False" "14.032" "3" "5" "8" "5" "1621" "181.6" "7.05" "18.70" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00588" "6894" "ENSG00000059588" "TARBP1" "hsa:6894; Q13395; Q9H581" "" "" "0" "0" "0.971" "0.944" "1.224" "0.976" "0.995" "1.050" "0.880" "0.839" "0.662" "634.3" "615.8" "599.0" "776.4" "619.1" "631.4" "666.1" "558.1" "532.5" "420.2" "" "" "" "" "" "" "" "" "" "" "335.9" "341.4" "343.0" "357.6" "335.0" "351.2" "392.0" "304.7" "298.7" "420.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4793391525152750587" "False" "High" "IsMasterProtein" "P61020" "Ras-related protein Rab-5B OS=Homo sapiens OX=9606 GN=RAB5B PE=1 SV=1" "0.000" "False" "13.997" "15" "3" "4" "1" "215" "23.7" "8.13" "11.30" "3" "cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5869" "ENSG00000111540" "RAB5B" "A8K982; B4DKD7; hsa:5869; P35239; P35277; P61020; Q6PIK9; Q86TH0; Q8IXL2" "Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Vasopressin-regulated water reabsorption" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Respiratory syncytial virus (RSV) attachment and entry; Clathrin-mediated endocytosis; TBC/RABGAPs" "9" "0" "1.010" "1.068" "1.078" "1.347" "1.254" "1.166" "1.268" "1.224" "0.663" "61.6" "62.2" "65.8" "66.4" "83.0" "77.2" "71.8" "78.1" "75.4" "40.9" "" "" "" "" "" "" "" "" "" "" "32.6" "34.5" "37.7" "30.6" "44.9" "43.0" "42.3" "42.7" "42.3" "40.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8894400129343683729" "False" "High" "IsMasterProtein" "Q9BUH6" "Protein PAXX OS=Homo sapiens OX=9606 GN=PAXX PE=1 SV=2" "0.000" "False" "13.991" "14" "3" "4" "3" "204" "21.6" "5.48" "12.03" "3" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf15384" "286257" "ENSG00000148362" "PAXX" "hsa:286257; Q8IY19; Q9BUH6" "" "" "0" "0" "1.035" "1.034" "1.124" "1.065" "1.048" "1.107" "1.043" "1.049" "0.600" "529.6" "548.4" "547.4" "595.0" "564.2" "555.2" "586.2" "552.2" "555.7" "317.6" "" "" "" "" "" "" "" "" "" "" "280.4" "304.0" "313.5" "274.0" "305.3" "308.8" "345.0" "301.4" "311.7" "317.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4154792399073788951" "False" "High" "IsMasterProtein" "Q13541" "Eukaryotic translation initiation factor 4E-binding protein 1 OS=Homo sapiens OX=9606 GN=EIF4EBP1 PE=1 SV=3" "0.000" "False" "13.967" "32" "2" "6" "2" "118" "12.6" "5.48" "18.23" "2" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05456" "1978" "ENSG00000187840" "EIF4EBP1" "B2R502; D3DSW8; hsa:1978; Q13541; Q6IBN3" "Translation factors; AMP-activated protein kinase signaling; Target of rapamycin signaling; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Androgen receptor network in prostate cancer; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; RAC1/PAK1/p38/MMP2 pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Hypertrophy model; Acute myeloid leukemia; Interferon type I signaling pathways; ErbB signaling pathway" "mTORC1-mediated signalling; Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S" "32" "0" "1.086" "0.977" "1.010" "1.029" "0.987" "0.933" "0.914" "0.933" "0.494" "284.0" "308.3" "277.4" "286.9" "292.1" "280.3" "264.8" "259.6" "264.9" "140.3" "" "" "" "" "" "" "" "" "" "" "150.4" "170.9" "158.9" "132.1" "158.0" "155.9" "155.9" "141.7" "148.6" "140.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7211345083341158849" "False" "High" "IsMasterProtein" "Q15382" "GTP-binding protein Rheb OS=Homo sapiens OX=9606 GN=RHEB PE=1 SV=1" "0.000" "False" "13.960" "22" "5" "6" "5" "184" "20.5" "5.92" "14.51" "5" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00071" "6009" "ENSG00000106615" "RHEB" "B3KWN6; D3DX13; hsa:6009; Q15382; Q53Y56; Q99444" "Target of rapamycin signaling; Follicle stimulating hormone (FSH) signaling pathway; Polycystic kidney disease pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Joubert syndrome; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway" "mTORC1-mediated signalling; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "26" "0" "0.970" "0.976" "0.931" "0.937" "1.001" "0.841" "0.909" "0.915" "0.544" "1285.0" "1245.9" "1254.4" "1195.9" "1204.2" "1286.6" "1081.2" "1168.0" "1176.4" "698.6" "" "" "" "" "" "" "" "" "" "" "680.4" "690.7" "718.4" "550.8" "651.5" "715.7" "636.3" "637.6" "659.9" "698.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8682459872602538883" "False" "High" "IsMasterProtein" "Q8N108" "Mesoderm induction early response protein 1 OS=Homo sapiens OX=9606 GN=MIER1 PE=1 SV=2" "0.000" "False" "13.954" "6" "3" "3" "3" "512" "57.9" "4.42" "8.50" "3" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf01448, Pf19426" "57708" "ENSG00000198160" "MIER1" "C9JFD4; hsa:57708; Q08AE0; Q32NC4; Q5T104; Q5TAD1; Q5TAD2; Q5TAD4; Q5TAD5; Q6AHY8; Q86TB4; Q8N108; Q8N156; Q8N161; Q8NC37; Q8NES4; Q8NES5; Q8NES6; Q8WWG2; Q9HCG2" "" "" "0" "0" "1.583" "1.734" "1.959" "1.502" "1.458" "1.706" "1.692" "1.360" "1.145" "35.1" "55.6" "60.8" "68.8" "52.7" "51.2" "59.9" "59.4" "47.7" "40.2" "" "" "" "" "" "" "" "" "" "" "18.6" "30.8" "34.8" "31.7" "28.5" "28.5" "35.2" "32.4" "26.8" "40.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3037731205086659877" "False" "High" "IsMasterProtein" "P09234" "U1 small nuclear ribonucleoprotein C OS=Homo sapiens OX=9606 GN=SNRPC PE=1 SV=1" "0.000" "False" "13.912" "13" "2" "5" "2" "159" "17.4" "9.67" "13.70" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06220" "6631" "ENSG00000124562" "SNRPC" "hsa:6631; P09234; Q5TAL3" "" "mRNA Splicing - Major Pathway" "1" "0" "1.029" "1.175" "1.127" "1.017" "1.100" "1.168" "1.224" "1.169" "0.514" "224.8" "231.3" "264.1" "253.3" "228.5" "247.2" "262.4" "275.2" "262.7" "115.5" "" "" "" "" "" "" "" "" "" "" "119.0" "128.3" "151.2" "116.6" "123.6" "137.5" "154.4" "150.2" "147.4" "115.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7625852785660981987" "False" "High" "IsMasterProtein" "Q15126" "Phosphomevalonate kinase OS=Homo sapiens OX=9606 GN=PMVK PE=1 SV=3" "0.000" "False" "13.907" "21" "4" "4" "4" "192" "22.0" "5.73" "11.81" "4" "other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle" "kinase activity;other molecular function" "Pf04275" "10654" "ENSG00000163344" "PMVK" "Q15126; Q5TZW9" "Cholesterol biosynthesis pathway; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "8" "0" "0.988" "0.956" "1.055" "1.172" "1.106" "1.017" "0.374" "1.004" "7.232" "182.6" "180.5" "174.6" "192.6" "214.1" "201.9" "185.7" "68.3" "183.4" "1320.7" "" "" "" "" "" "" "" "" "" "" "96.7" "100.1" "100.0" "88.7" "115.8" "112.3" "109.3" "37.3" "102.9" "1320.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1595519607435168922" "False" "High" "IsMasterProtein" "P31942" "Heterogeneous nuclear ribonucleoprotein H3 OS=Homo sapiens OX=9606 GN=HNRNPH3 PE=1 SV=2" "0.000" "False" "13.903" "9" "3" "5" "3" "346" "36.9" "6.87" "13.38" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00076" "3189" "ENSG00000096746" "HNRNPH3" "A8K682; B3KRE1; hsa:3189; P31942; Q9BSX1; Q9NP53; Q9NP96; Q9NPA7; Q9NPI4; Q9UFU4; Q9Y4J5" "" "" "0" "0" "0.959" "0.919" "1.119" "1.016" "0.931" "1.312" "1.290" "1.373" "3.314" "47.8" "45.8" "43.9" "53.4" "48.5" "44.5" "62.7" "61.6" "65.6" "158.3" "" "" "" "" "" "" "" "" "" "" "25.3" "25.4" "25.1" "24.6" "26.3" "24.7" "36.9" "33.6" "36.8" "158.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5233814876495562801" "False" "High" "IsMasterProtein" "P00966" "Argininosuccinate synthase OS=Homo sapiens OX=9606 GN=ASS1 PE=1 SV=2" "0.000" "False" "13.874" "12" "6" "9" "6" "412" "46.5" "8.02" "21.67" "6" "other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00764, Pf20979" "445" "ENSG00000130707" "ASS1" "hsa:445; P00966; Q6LDL2; Q86UZ0; Q96GT4" "Alanine and aspartate metabolism; Amino acid metabolism" "Urea cycle" "3" "0" "0.979" "0.975" "0.965" "1.022" "1.058" "0.891" "0.932" "0.875" "0.687" "1693.5" "1657.2" "1651.9" "1634.5" "1730.1" "1790.8" "1508.2" "1579.1" "1481.8" "1163.2" "" "" "" "" "" "" "" "" "" "" "896.7" "918.8" "946.0" "752.7" "936.0" "996.2" "887.6" "862.0" "831.2" "1163.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5616510837335031809" "False" "High" "IsMasterProtein" "P15586" "N-acetylglucosamine-6-sulfatase OS=Homo sapiens OX=9606 GN=GNS PE=1 SV=3" "0.000" "False" "13.853" "5" "2" "5" "2" "552" "62.0" "8.31" "11.84" "2" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00884" "2799" "ENSG00000135677" "GNS" "B4DYH8; hsa:2799; P15586; Q53F05" "Glycosaminoglycan degradation" "Neutrophil degranulation; Lysosome Vesicle Biogenesis; Keratan sulfate degradation; MPS IIID - Sanfilippo syndrome D" "5" "0" "1.164" "1.035" "0.942" "0.982" "1.023" "0.895" "1.084" "1.051" "0.505" "272.9" "317.7" "282.4" "257.0" "268.1" "279.2" "244.1" "295.9" "286.8" "137.8" "" "" "" "" "" "" "" "" "" "" "144.5" "176.2" "161.7" "118.4" "145.0" "155.3" "143.7" "161.5" "160.9" "137.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2633610480889665575" "False" "High" "IsMasterProtein" "O75608" "Acyl-protein thioesterase 1 OS=Homo sapiens OX=9606 GN=LYPLA1 PE=1 SV=1" "0.000" "False" "13.840" "15" "4" "8" "4" "230" "24.7" "6.77" "25.86" "4" "protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02230" "10434" "ENSG00000120992" "LYPLA1" "hsa:10434; O43202; O75608; Q9UQF9" "" "RAS processing; eNOS activation" "2" "0" "0.944" "0.931" "0.949" "1.004" "0.987" "1.004" "1.011" "0.969" "0.459" "2151.6" "2031.9" "2002.2" "2041.4" "2159.3" "2123.1" "2160.4" "2176.0" "2084.8" "987.6" "" "" "" "" "" "" "" "" "" "" "1139.3" "1126.6" "1146.7" "940.1" "1168.2" "1181.0" "1271.5" "1187.8" "1169.5" "987.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7926750901402698685" "False" "High" "IsMasterProtein" "Q9UKG1" "DCC-interacting protein 13-alpha OS=Homo sapiens OX=9606 GN=APPL1 PE=1 SV=1" "0.000" "False" "13.822" "6" "3" "3" "3" "709" "79.6" "5.41" "8.95" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00640, Pf16746" "26060" "ENSG00000157500" "APPL1" "hsa:26060; Q9P2B9; Q9UKG1" "Follicle stimulating hormone (FSH) signaling pathway; Chromosomal and microsatellite instability in colorectal cancer" "Caspase activation via Dependence Receptors in the absence of ligand" "3" "0" "1.397" "1.045" "1.538" "1.522" "1.103" "1.375" "1.356" "1.226" "1.307" "43.7" "61.1" "45.7" "67.3" "66.6" "48.3" "60.2" "59.3" "53.6" "57.2" "" "" "" "" "" "" "" "" "" "" "23.2" "33.9" "26.2" "31.0" "36.0" "26.8" "35.4" "32.4" "30.1" "57.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8386790215885090291" "False" "High" "IsMasterProtein" "Q8N3X1" "Formin-binding protein 4 OS=Homo sapiens OX=9606 GN=FNBP4 PE=1 SV=3" "0.000" "False" "13.778" "3" "3" "5" "3" "1017" "110.2" "4.74" "13.93" "3" "" "nucleus" "" "Pf00397" "23360" "ENSG00000109920; ENSG00000285182" "FNBP4" "hsa:23360; Q8N3X1; Q9H985; Q9NT81; Q9Y2L7" "" "" "0" "0" "0.978" "1.183" "1.043" "1.417" "1.075" "1.208" "1.091" "1.516" "0.523" "30.9" "30.2" "36.6" "32.2" "43.8" "33.2" "37.3" "33.7" "46.9" "16.2" "" "" "" "" "" "" "" "" "" "" "16.4" "16.8" "20.9" "14.8" "23.7" "18.5" "22.0" "18.4" "26.3" "16.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2260804329009372873" "False" "High" "IsMasterProtein" "Q13045" "Protein flightless-1 homolog OS=Homo sapiens OX=9606 GN=FLII PE=1 SV=2" "0.000" "False" "13.777" "4" "7" "8" "7" "1269" "144.7" "6.05" "15.53" "7" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00560, Pf00626, Pf12799, Pf13855" "2314" "ENSG00000177731; ENSG00000284571" "FLII" "B4DIL0; F5H407; hsa:2314; J3QLG3; Q13045" "VEGFA-VEGFR2 signaling; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "" "2" "0" "0.957" "0.954" "0.871" "0.971" "0.969" "0.806" "0.569" "0.861" "3.885" "376.3" "360.0" "358.8" "327.9" "365.4" "364.6" "303.4" "214.2" "324.1" "1462.0" "" "" "" "" "" "" "" "" "" "" "199.3" "199.6" "205.5" "151.0" "197.7" "202.8" "178.6" "116.9" "181.8" "1462.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6709781459489319409" "False" "High" "IsMasterProtein" "Q9UHN1" "DNA polymerase subunit gamma-2 OS=Homo sapiens OX=9606 GN=POLG2 PE=1 SV=1" "0.000" "False" "13.771" "8" "3" "4" "3" "485" "54.9" "8.35" "13.66" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "mitochondrion;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf03129" "11232" "ENSG00000256525" "POLG2" "hsa:11232; O00419; Q0IJ81; Q96GW2; Q9UHN1; Q9UK35; Q9UK94" "" "Transcriptional activation of mitochondrial biogenesis" "1" "0" "1.217" "1.130" "1.273" "1.213" "1.156" "1.244" "1.141" "1.127" "0.683" "158.9" "193.4" "179.6" "202.4" "192.8" "183.8" "197.7" "181.4" "179.1" "108.6" "" "" "" "" "" "" "" "" "" "" "84.2" "107.2" "102.9" "93.2" "104.3" "102.2" "116.3" "99.0" "100.5" "108.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5853240527723212968" "False" "High" "IsMasterProtein" "Q9H7Z7" "Prostaglandin E synthase 2 OS=Homo sapiens OX=9606 GN=PTGES2 PE=1 SV=1" "0.000" "False" "13.767" "9" "4" "4" "4" "377" "41.9" "9.16" "10.66" "4" "other metabolic processes;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf13410, Pf13417" "80142" "ENSG00000148334" "PTGES2" "hsa:80142; Q53EW9; Q5SYV6; Q96GI0; Q96GL2; Q9H7Z7" "Relationship between inflammation, COX-2 and EGFR; Omega-6-fatty acids in senescence" "Neutrophil degranulation; Synthesis of Prostaglandins (PG) and Thromboxanes (TX)" "4" "0" "0.955" "0.964" "0.863" "0.921" "0.958" "0.796" "0.825" "0.852" "0.781" "1032.4" "985.4" "995.0" "890.7" "950.6" "988.8" "821.5" "851.9" "880.0" "806.7" "" "" "" "" "" "" "" "" "" "" "546.6" "546.3" "569.8" "410.2" "514.3" "550.0" "483.5" "465.0" "493.7" "806.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3065352799485715425" "False" "High" "IsMasterProtein" "Q9P0P0" "E3 ubiquitin-protein ligase RNF181 OS=Homo sapiens OX=9606 GN=RNF181 PE=1 SV=1" "0.000" "False" "13.763" "25" "4" "5" "4" "153" "17.9" "5.06" "14.41" "4" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf13639" "51255" "ENSG00000168894" "RNF181" "hsa:51255; Q53H81; Q9P0P0" "" "E3 ubiquitin ligases ubiquitinate target proteins" "1" "0" "0.947" "0.976" "0.912" "0.978" "0.929" "0.834" "0.982" "1.024" "0.560" "696.2" "659.3" "679.8" "634.9" "681.1" "646.9" "580.3" "683.9" "712.7" "390.0" "" "" "" "" "" "" "" "" "" "" "368.6" "365.6" "389.3" "292.4" "368.5" "359.9" "341.5" "373.3" "399.8" "390.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3980746601808787358" "False" "High" "IsMasterProtein" "Q9P1U1" "Actin-related protein 3B OS=Homo sapiens OX=9606 GN=ACTR3B PE=1 SV=1" "0.000" "False" "13.760" "9" "4" "12" "1" "418" "47.6" "5.88" "29.01" "4" "" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "57180" "ENSG00000133627" "ACTR3B" "A8MTG1; B4DFW4; hsa:57180; Q7Z526; Q96BT2; Q9P1U1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7500811780682688662" "False" "High" "IsMasterProtein" "Q8N8S7" "Protein enabled homolog OS=Homo sapiens OX=9606 GN=ENAH PE=1 SV=2" "0.000" "False" "13.744" "7" "5" "10" "4" "591" "66.5" "6.93" "23.60" "5" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00568, Pf08776" "55740" "ENSG00000154380" "ENAH" "D0PQI2; hsa:55740; Q502W5; Q5T5M7; Q5VTQ9; Q5VTR0; Q8N8S7; Q9NVF3; Q9UFB8" "Regulation of actin cytoskeleton" "Generation of second messenger molecules; Signaling by ROBO receptors" "3" "0" "2.067" "1.028" "1.349" "1.198" "1.189" "1.277" "1.108" "1.457" "0.969" "195.1" "403.4" "200.6" "263.3" "233.8" "232.1" "249.2" "216.1" "284.3" "189.1" "" "" "" "" "" "" "" "" "" "" "103.3" "223.7" "114.9" "121.3" "126.5" "129.1" "146.7" "118.0" "159.5" "189.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8984223167418137130" "False" "High" "IsMasterProtein" "P62633" "CCHC-type zinc finger nucleic acid binding protein OS=Homo sapiens OX=9606 GN=CNBP PE=1 SV=1" "0.000" "False" "13.729" "25" "5" "5" "5" "177" "19.5" "7.71" "14.62" "5" "DNA metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;other cell component" "nucleic acid binding activity;other molecular function" "Pf00098" "7555" "ENSG00000169714" "CNBP" "A8K7V4; B2RAV9; B4DP17; D3DNB9; D3DNC0; D3DNC1; E9PDR7; hsa:7555; P20694; P62633; Q4JGY0; Q4JGY1; Q5QJR0; Q5U0E9; Q6PJI7; Q96NV3" "" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "1" "0" "1.027" "1.029" "0.985" "1.042" "0.926" "1.043" "0.877" "0.923" "0.562" "626.9" "643.8" "645.3" "617.2" "653.4" "580.5" "653.8" "549.7" "578.4" "352.5" "" "" "" "" "" "" "" "" "" "" "332.0" "356.9" "369.6" "284.3" "353.5" "322.9" "384.8" "300.0" "324.5" "352.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2825408205880823904" "False" "High" "IsMasterProtein" "P14635" "G2/mitotic-specific cyclin-B1 OS=Homo sapiens OX=9606 GN=CCNB1 PE=1 SV=1" "0.000" "False" "13.722" "7" "3" "3" "3" "433" "48.3" "7.47" "11.02" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00134, Pf02984" "891" "ENSG00000134057" "CCNB1" "A8K066; hsa:891; P14635; Q5TZP9" "AMP-activated protein kinase signaling; miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATM signaling pathway; G1 to S cell cycle control; GDNF signaling; IL-19 signaling pathway; DNA damage response" "The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; APC/C:Cdc20 mediated degradation of Cyclin B; Phosphorylation of the APC/C; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Cyclin A/B1/B2 associated events during G2/M transition; Transcriptional regulation by RUNX2; MASTL Facilitates Mitotic Progression; E2F-enabled inhibition of pre-replication complex formation; Golgi Cisternae Pericentriolar Stack Reorganization; Condensation of Prophase Chromosomes; Initiation of Nuclear Envelope (NE) Reformation; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint; Depolymerization of the Nuclear Lamina; Nuclear events stimulated by ALK signaling in cancer; Phosphorylation of Emi1" "33" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4733081690105890722" "False" "High" "IsMasterProtein" "Q9UKN8" "General transcription factor 3C polypeptide 4 OS=Homo sapiens OX=9606 GN=GTF3C4 PE=1 SV=2" "0.000" "False" "13.711" "5" "5" "6" "5" "822" "91.9" "6.65" "13.82" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf12657, Pf12660, Pf19336" "9329" "ENSG00000125484" "GTF3C4" "hsa:9329; Q5VZJ7; Q9UKN8" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "3" "0" "0.948" "0.956" "0.949" "1.051" "1.005" "1.130" "1.008" "1.039" "1.390" "611.7" "580.0" "584.5" "580.2" "643.1" "614.7" "691.2" "616.3" "635.5" "850.2" "" "" "" "" "" "" "" "" "" "" "323.9" "321.6" "334.7" "267.2" "347.9" "341.9" "406.8" "336.4" "356.5" "850.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4570011154676120481" "False" "High" "IsMasterProtein" "Q9NRF9" "DNA polymerase epsilon subunit 3 OS=Homo sapiens OX=9606 GN=POLE3 PE=1 SV=1" "0.000" "False" "13.707" "27" "3" "4" "3" "147" "16.8" "4.74" "11.52" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "54107" "ENSG00000148229" "POLE3" "hsa:54107; Q5W0U1; Q8N758; Q8NCE5; Q9NR32; Q9NRF9" "Pyrimidine metabolism; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Activation of the pre-replicative complex; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Gap-filling DNA repair synthesis and ligation in GG-NER; PCNA-Dependent Long Patch Base Excision Repair; DNA replication initiation" "16" "0" "1.055" "1.170" "0.930" "1.064" "1.014" "0.949" "1.200" "1.145" "0.955" "564.9" "595.8" "660.9" "525.1" "601.2" "572.6" "536.3" "677.8" "647.0" "539.4" "" "" "" "" "" "" "" "" "" "" "299.1" "330.3" "378.5" "241.8" "325.3" "318.5" "315.6" "370.0" "362.9" "539.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5615919369887998349" "False" "High" "IsMasterProtein" "P49903" "Selenide, water dikinase 1 OS=Homo sapiens OX=9606 GN=SEPHS1 PE=1 SV=2" "0.000" "False" "13.689" "15" "5" "7" "4" "392" "42.9" "5.97" "12.48" "5" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;nucleus;other cell component" "kinase activity;other molecular function" "Pf00586, Pf02769" "22929" "ENSG00000086475" "SEPHS1" "B4DWK0; D3DRS9; D6PSQ9; hsa:22929; P49903; Q5T5U8; Q5T5U9; Q9BVT4" "" "" "0" "1" "0.956" "0.999" "1.257" "1.008" "1.020" "1.047" "1.002" "1.005" "0.585" "317.5" "303.5" "317.1" "399.1" "320.1" "324.0" "332.6" "318.1" "319.1" "185.9" "" "" "" "" "" "" "" "" "" "" "168.1" "168.3" "181.6" "183.8" "173.2" "180.2" "195.7" "173.6" "179.0" "185.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1511141278890819027" "False" "High" "IsMasterProtein" "O14802" "DNA-directed RNA polymerase III subunit RPC1 OS=Homo sapiens OX=9606 GN=POLR3A PE=1 SV=2" "0.000" "False" "13.668" "3" "5" "5" "5" "1390" "155.5" "8.48" "10.63" "5" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00623, Pf04983, Pf04997, Pf04998, Pf05000" "11128" "ENSG00000148606" "POLR3A" "hsa:11128; O14802; Q8IW34; Q8TCW5" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "9" "0" "1.079" "1.042" "1.187" "1.049" "0.928" "1.114" "0.873" "1.084" "3.109" "275.9" "297.6" "287.5" "327.4" "289.3" "255.9" "307.4" "241.0" "299.2" "857.6" "" "" "" "" "" "" "" "" "" "" "146.1" "165.0" "164.7" "150.8" "156.5" "142.4" "180.9" "131.5" "167.8" "857.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1860975273197737865" "False" "High" "IsMasterProtein" "P19784" "Casein kinase II subunit alpha' OS=Homo sapiens OX=9606 GN=CSNK2A2 PE=1 SV=1" "0.000" "False" "13.667" "13" "3" "3" "3" "350" "41.2" "8.56" "10.17" "3" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1459" "ENSG00000070770" "CSNK2A2" "hsa:1459; P19784" "Alzheimer's disease and miRNA effects; Allograft rejection; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Measles virus infection; Pleural mesothelioma; Alzheimer's disease; HDAC6 interactions in the central nervous system" "Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of TP53 Activity through Phosphorylation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Maturation of hRSV A proteins; Receptor Mediated Mitophagy; Condensation of Prometaphase Chromosomes; Synthesis of PC" "21" "0" "0.717" "0.796" "1.073" "0.624" "0.869" "1.039" "0.774" "0.764" "0.998" "37.7" "27.0" "30.0" "40.5" "23.5" "32.8" "39.2" "29.2" "28.8" "37.6" "" "" "" "" "" "" "" "" "" "" "20.0" "15.0" "17.2" "18.7" "12.7" "18.2" "23.1" "15.9" "16.2" "37.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7179197342339518209" "False" "High" "IsMasterProtein" "P52907" "F-actin-capping protein subunit alpha-1 OS=Homo sapiens OX=9606 GN=CAPZA1 PE=1 SV=3" "0.000" "False" "13.666" "14" "3" "3" "2" "286" "32.9" "5.69" "8.88" "3" "cell organization and biogenesis" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01267" "829" "ENSG00000116489" "CAPZA1" "hsa:829; P52907; Q53FQ6; Q6FHD5" "" "MHC class II antigen presentation; COPI-mediated anterograde transport; Sensory processing of sound by inner hair cells of the cochlea; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Factors involved in megakaryocyte development and platelet production; Advanced glycosylation endproduct receptor signaling" "8" "0" "1.136" "1.022" "1.191" "1.309" "1.096" "1.224" "1.187" "1.363" "0.856" "34.9" "39.7" "35.7" "41.6" "45.7" "38.3" "42.7" "41.5" "47.6" "29.9" "" "" "" "" "" "" "" "" "" "" "18.5" "22.0" "20.4" "19.1" "24.7" "21.3" "25.1" "22.6" "26.7" "29.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-917272071926626278" "False" "High" "IsMasterProtein" "Q99797" "Mitochondrial intermediate peptidase OS=Homo sapiens OX=9606 GN=MIPEP PE=1 SV=2" "0.000" "False" "13.666" "7" "6" "8" "5" "713" "80.6" "7.05" "12.72" "6" "protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf01432" "4285" "ENSG00000027001" "MIPEP" "hsa:4285; Q5JV15; Q5T9Q9; Q96G65; Q99797" "13q12.12 copy number variation" "" "1" "0" "1.043" "1.097" "0.884" "1.028" "1.215" "1.057" "1.019" "1.011" "1.259" "58.8" "61.3" "64.5" "52.0" "60.4" "71.5" "62.2" "59.9" "59.4" "74.0" "" "" "" "" "" "" "" "" "" "" "31.1" "34.0" "36.9" "24.0" "32.7" "39.8" "36.6" "32.7" "33.3" "74.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8321925279742634811" "False" "High" "IsMasterProtein" "Q9Y6Y8" "SEC23-interacting protein OS=Homo sapiens OX=9606 GN=SEC23IP PE=1 SV=1" "0.000" "False" "13.657" "6" "6" "6" "6" "1000" "111.0" "5.54" "12.59" "6" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00536, Pf02825, Pf02862" "11196" "ENSG00000107651" "SEC23IP" "D3DRD2; hsa:11196; Q8IXH5; Q9BUK5; Q9Y6Y8" "" "COPII-mediated vesicle transport" "1" "0" "1.035" "1.017" "1.045" "0.996" "0.993" "0.968" "0.831" "0.915" "2.114" "496.3" "513.6" "504.7" "518.8" "494.4" "492.9" "480.6" "412.4" "454.3" "1049.4" "" "" "" "" "" "" "" "" "" "" "262.8" "284.7" "289.0" "238.9" "267.5" "274.1" "282.8" "225.1" "254.9" "1049.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5669236386910036788" "False" "High" "IsMasterProtein" "P46783" "Small ribosomal subunit protein eS10 OS=Homo sapiens OX=9606 GN=RPS10 PE=1 SV=1" "0.000" "False" "13.630" "29" "5" "7" "5" "165" "18.9" "10.15" "9.71" "5" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf03501" "6204" "ENSG00000124614" "RPS10" "B2R4E3; hsa:6204; P46783; Q5TZC0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.009" "1.061" "1.192" "1.146" "1.300" "1.325" "1.222" "1.517" "1.435" "384.7" "388.2" "408.3" "458.7" "440.9" "500.0" "509.8" "470.1" "583.6" "551.9" "" "" "" "" "" "" "" "" "" "" "203.7" "215.2" "233.8" "211.2" "238.6" "278.1" "300.0" "256.6" "327.4" "551.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1901322686263979467" "False" "High" "IsMasterProtein" "Q32P44" "Echinoderm microtubule-associated protein-like 3 OS=Homo sapiens OX=9606 GN=EML3 PE=1 SV=1" "0.000" "False" "13.627" "4" "3" "3" "3" "896" "95.1" "7.12" "9.83" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf03451" "256364" "ENSG00000149499" "EML3" "hsa:256364; Q32P44; Q6ZQW7; Q8NA55" "" "" "0" "0" "1.046" "1.080" "0.804" "0.960" "1.024" "1.003" "1.004" "1.040" "1.707" "175.2" "183.2" "189.1" "140.8" "168.2" "179.4" "175.7" "175.9" "182.3" "299.0" "" "" "" "" "" "" "" "" "" "" "92.8" "101.6" "108.3" "64.8" "91.0" "99.8" "103.4" "96.0" "102.2" "299.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1688448728000248200" "False" "High" "IsMasterProtein" "Q9BZH6" "WD repeat-containing protein 11 OS=Homo sapiens OX=9606 GN=WDR11 PE=1 SV=1" "0.000" "False" "13.618" "5" "6" "8" "6" "1224" "136.6" "6.92" "15.05" "6" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "" "" "55717" "ENSG00000120008" "WDR11" "hsa:55717; Q5VWA1; Q9BZH6; Q9P2J6" "" "RHOH GTPase cycle" "1" "0" "0.996" "0.995" "1.041" "0.996" "1.213" "1.087" "0.921" "1.119" "0.848" "693.5" "691.0" "690.0" "722.0" "690.9" "841.5" "753.9" "638.5" "776.2" "588.4" "" "" "" "" "" "" "" "" "" "" "367.2" "383.1" "395.1" "332.5" "373.8" "468.1" "443.7" "348.5" "435.4" "588.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6043879365308815932" "False" "High" "IsMasterProtein" "O75818" "Ribonuclease P protein subunit p40 OS=Homo sapiens OX=9606 GN=RPP40 PE=1 SV=3" "0.000" "False" "13.601" "12" "4" "4" "4" "363" "41.8" "6.67" "11.12" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08584" "10799" "ENSG00000124787" "RPP40" "hsa:10799; O75818; Q5VX97; Q8WVK8" "" "tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol" "2" "0" "1.150" "1.166" "1.106" "1.050" "1.046" "1.082" "1.065" "1.032" "0.758" "132.0" "151.8" "154.0" "146.0" "138.6" "138.1" "142.9" "140.6" "136.3" "100.1" "" "" "" "" "" "" "" "" "" "" "69.9" "84.2" "88.2" "67.2" "75.0" "76.8" "84.1" "76.7" "76.5" "100.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6342427626710048975" "False" "High" "IsMasterProtein" "Q96SW2" "Protein cereblon OS=Homo sapiens OX=9606 GN=CRBN PE=1 SV=1" "0.000" "False" "13.586" "9" "3" "4" "3" "442" "50.5" "5.63" "8.84" "3" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf02190, Pf03226" "51185" "ENSG00000113851" "CRBN" "B2R6H4; C9IZA9; C9JAH6; hsa:51185; Q6AI62; Q6NVZ0; Q96SW2; Q9UHW4" "" "Potential therapeutics for SARS" "1" "0" "0.991" "0.927" "1.176" "1.065" "0.984" "1.131" "1.003" "0.875" "0.607" "167.1" "165.5" "154.8" "196.5" "177.9" "164.3" "188.9" "167.5" "146.2" "101.5" "" "" "" "" "" "" "" "" "" "" "88.5" "91.7" "88.7" "90.5" "96.2" "91.4" "111.2" "91.4" "82.0" "101.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "779708130048871486" "False" "High" "IsMasterProtein" "O43464" "Serine protease HTRA2, mitochondrial OS=Homo sapiens OX=9606 GN=HTRA2 PE=1 SV=2" "0.000" "False" "13.575" "5" "2" "3" "2" "458" "48.8" "10.07" "11.97" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf13365, Pf17820" "27429" "ENSG00000115317" "HTRA2" "hsa:27429; O43464; Q9HBZ4; Q9P0Y3; Q9P0Y4" "Apoptosis modulation and signaling; Parkinson's disease pathway; Nanomaterial induced apoptosis; Ciliary landscape; Complement system in neuronal development and plasticity" "Mitochondrial protein degradation" "6" "0" "1.031" "0.976" "0.918" "0.943" "1.065" "0.840" "0.803" "0.931" "0.593" "333.7" "344.1" "325.6" "306.3" "314.8" "355.4" "280.4" "268.0" "310.6" "198.0" "" "" "" "" "" "" "" "" "" "" "176.7" "190.8" "186.5" "141.0" "170.3" "197.7" "165.0" "146.3" "174.2" "198.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3647234260862617095" "False" "High" "IsMasterProtein" "Q8TEA8" "D-aminoacyl-tRNA deacylase 1 OS=Homo sapiens OX=9606 GN=DTD1 PE=1 SV=2" "0.000" "False" "13.554" "15" "3" "3" "3" "209" "23.4" "8.24" "9.39" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02580" "92675" "ENSG00000125821" "DTD1" "A8K5X5; D3DW37; hsa:92675; Q496D1; Q5W184; Q8TEA8; Q8WXU8; Q9BW67; Q9H464; Q9H474" "" "" "0" "0" "1.010" "1.130" "1.225" "1.180" "1.130" "1.178" "1.137" "1.062" "0.730" "145.1" "146.5" "164.0" "177.8" "171.2" "163.9" "170.9" "164.9" "154.1" "105.9" "" "" "" "" "" "" "" "" "" "" "76.8" "81.2" "93.9" "81.9" "92.6" "91.2" "100.6" "90.0" "86.4" "105.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1822975009015350041" "False" "High" "IsMasterProtein" "P60228" "Eukaryotic translation initiation factor 3 subunit E OS=Homo sapiens OX=9606 GN=EIF3E PE=1 SV=1" "0.000" "False" "13.540" "10" "4" "4" "4" "445" "52.2" "6.04" "10.13" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf01399, Pf09440, Pf21357" "3646" "ENSG00000104408" "EIF3E" "hsa:3646; O43902; P60228; Q64058; Q64059; Q64252; Q6FG33; Q8WVK4" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "0" "1.013" "1.160" "1.181" "1.154" "1.151" "1.194" "0.953" "1.155" "1.915" "179.6" "181.9" "208.4" "212.2" "207.3" "206.8" "214.4" "171.2" "207.5" "344.0" "" "" "" "" "" "" "" "" "" "" "95.1" "100.8" "119.4" "97.7" "112.1" "115.0" "126.2" "93.5" "116.4" "344.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7881341601402710105" "False" "High" "IsMasterProtein" "Q8IYQ7" "Threonine synthase-like 1 OS=Homo sapiens OX=9606 GN=THNSL1 PE=1 SV=2" "0.000" "False" "13.537" "6" "4" "4" "4" "743" "83.0" "7.12" "7.87" "4" "" "other cell component" "" "Pf01202, Pf14821" "79896" "ENSG00000185875" "THNSL1" "B3KWL1; D3DRV3; hsa:79896; Q5VV21; Q8IYQ7" "" "" "0" "0" "0.964" "0.963" "1.038" "0.994" "0.911" "1.012" "1.003" "0.859" "0.669" "233.0" "224.6" "224.3" "241.8" "231.5" "212.2" "235.7" "233.6" "200.2" "155.9" "" "" "" "" "" "" "" "" "" "" "123.4" "124.5" "128.4" "111.4" "125.3" "118.0" "138.7" "127.5" "112.3" "155.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5869827592286108947" "False" "High" "IsMasterProtein" "Q9UPQ9" "Trinucleotide repeat-containing gene 6B protein OS=Homo sapiens OX=9606 GN=TNRC6B PE=1 SV=4" "0.000" "False" "13.537" "2" "2" "2" "2" "1833" "193.9" "6.76" "7.87" "2" "other biological processes" "cytosol;nucleus;other cell component" "" "Pf10427, Pf16608" "23112" "ENSG00000100354" "TNRC6B" "B0QY73; B0QY78; B4DGC0; hsa:23112; Q5TH52; Q8TBX2; Q9UPQ9" "" "Oxidative Stress Induced Senescence; MAPK6/MAPK4 signaling; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Ca2+ pathway; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "18" "0" "0.978" "0.971" "1.025" "1.090" "0.986" "1.309" "1.315" "1.307" "0.971" "133.5" "130.5" "129.5" "136.8" "145.5" "131.6" "174.7" "175.5" "174.5" "129.6" "" "" "" "" "" "" "" "" "" "" "70.7" "72.4" "74.2" "63.0" "78.7" "73.2" "102.8" "95.8" "97.9" "129.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7629254407620291846" "False" "High" "IsMasterProtein" "Q15428" "Splicing factor 3A subunit 2 OS=Homo sapiens OX=9606 GN=SF3A2 PE=1 SV=2" "0.000" "False" "13.534" "9" "4" "6" "4" "464" "49.2" "9.64" "10.83" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf12874, Pf16835" "8175" "ENSG00000104897" "SF3A2" "B2RBU1; D6W605; hsa:8175; O75245; Q15428" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.976" "0.945" "1.108" "0.957" "0.951" "0.983" "1.024" "0.879" "1.506" "205.3" "200.2" "193.9" "227.5" "196.4" "195.2" "201.8" "210.3" "180.3" "309.2" "" "" "" "" "" "" "" "" "" "" "108.7" "111.0" "111.0" "104.8" "106.2" "108.6" "118.8" "114.8" "101.2" "309.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3957617844882623254" "False" "High" "IsMasterProtein" "Q7Z3B4" "Nucleoporin p54 OS=Homo sapiens OX=9606 GN=NUP54 PE=1 SV=2" "0.000" "False" "13.532" "6" "3" "5" "3" "507" "55.4" "7.02" "17.12" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;nucleus" "other molecular function" "Pf13874, Pf18437" "53371" "ENSG00000138750" "NUP54" "B2RCK7; B4DT35; hsa:53371; Q7Z3B4; Q96EA7; Q9NVL5; Q9P0I1" "" "Regulation of HSF1-mediated heat shock response; snRNP Assembly; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation" "29" "0" "1.005" "0.956" "0.926" "1.081" "0.952" "0.915" "0.982" "1.002" "1.380" "376.0" "378.0" "359.6" "348.2" "406.6" "358.1" "344.2" "369.4" "376.9" "519.0" "" "" "" "" "" "" "" "" "" "" "199.1" "209.6" "205.9" "160.4" "220.0" "199.2" "202.5" "201.6" "211.4" "519.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1363881983208351205" "False" "High" "IsMasterProtein" "Q15438" "Cytohesin-1 OS=Homo sapiens OX=9606 GN=CYTH1 PE=1 SV=1" "0.000" "False" "13.531" "12" "4" "4" "4" "398" "46.4" "5.54" "11.47" "4" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf01369" "9267" "ENSG00000108669" "CYTH1" "A6NFW7; B7Z1T4; hsa:9267; Q15438; Q9P123; Q9P124" "2q37 copy number variation syndrome" "Intra-Golgi traffic" "2" "0" "1.068" "0.914" "1.138" "1.024" "1.069" "1.059" "0.870" "1.000" "1.000" "385.5" "411.9" "352.3" "438.9" "394.6" "412.0" "408.1" "335.6" "385.6" "385.4" "" "" "" "" "" "" "" "" "" "" "204.1" "228.3" "201.7" "202.1" "213.5" "229.2" "240.2" "183.2" "216.3" "385.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4014732936272449079" "False" "High" "IsMasterProtein" "Q53EL6" "Programmed cell death protein 4 OS=Homo sapiens OX=9606 GN=PDCD4 PE=1 SV=2" "0.000" "False" "13.524" "5" "2" "2" "2" "469" "51.7" "5.21" "8.03" "2" "developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf02847" "27250" "ENSG00000150593" "PDCD4" "B2RCV4; B5ME91; hsa:27250; O15501; Q53EL6; Q5VZS6; Q6PJI5; Q8TAR5; Q99834" "Translation inhibitors in chronically activated PDGFRA cells; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "4" "0" "0.942" "0.945" "0.936" "0.954" "0.960" "0.955" "0.850" "0.773" "1.689" "166.3" "156.6" "157.1" "155.7" "158.7" "159.6" "158.8" "141.4" "128.6" "280.8" "" "" "" "" "" "" "" "" "" "" "88.0" "86.8" "90.0" "71.7" "85.9" "88.8" "93.5" "77.2" "72.1" "280.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4830311805247258078" "False" "High" "IsMasterProtein" "Q9NPD3" "Exosome complex component RRP41 OS=Homo sapiens OX=9606 GN=EXOSC4 PE=1 SV=3" "0.000" "False" "13.521" "12" "3" "4" "3" "245" "26.4" "6.52" "13.21" "3" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "54512" "ENSG00000178896" "EXOSC4" "hsa:54512; Q9NPD3" "Ciliary landscape" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "7" "0" "1.033" "1.106" "0.973" "0.975" "0.968" "1.088" "1.139" "1.011" "0.463" "151.3" "156.3" "167.3" "147.3" "147.5" "146.4" "164.7" "172.4" "153.0" "70.0" "" "" "" "" "" "" "" "" "" "" "80.1" "86.6" "95.8" "67.8" "79.8" "81.4" "96.9" "94.1" "85.8" "70.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6380773280211833227" "False" "High" "IsMasterProtein" "Q9Y508" "E3 ubiquitin-protein ligase RNF114 OS=Homo sapiens OX=9606 GN=RNF114 PE=1 SV=1" "0.000" "False" "13.520" "16" "4" "6" "4" "228" "25.7" "7.25" "13.90" "4" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf05605, Pf13445, Pf18574" "55905" "ENSG00000124226" "RNF114" "B2RDQ9; B4DWY5; E1P627; hsa:55905; Q6N0B0; Q9Y508" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.944" "1.026" "0.990" "0.964" "0.929" "0.855" "1.040" "0.887" "0.565" "357.2" "337.3" "366.7" "353.6" "344.4" "332.0" "305.6" "371.7" "317.0" "201.9" "" "" "" "" "" "" "" "" "" "" "189.2" "187.0" "210.0" "162.8" "186.4" "184.7" "179.9" "202.9" "177.8" "201.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3984777124948273039" "False" "High" "IsMasterProtein" "O94903" "Pyridoxal phosphate homeostasis protein OS=Homo sapiens OX=9606 GN=PLPBP PE=1 SV=1" "0.000" "False" "13.518" "12" "4" "9" "4" "275" "30.3" "7.50" "25.00" "4" "" "cytosol;other cell component" "other molecular function" "Pf01168" "11212" "ENSG00000147471" "PLPBP" "O94903; Q6FI94" "" "" "0" "0" "1.055" "1.063" "1.059" "1.050" "1.136" "1.111" "0.881" "1.009" "3.702" "299.0" "315.6" "317.7" "316.6" "314.0" "339.7" "332.1" "263.4" "301.6" "1107.0" "" "" "" "" "" "" "" "" "" "" "158.3" "175.0" "182.0" "145.8" "169.9" "189.0" "195.4" "143.8" "169.2" "1107.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2309568012740462624" "False" "High" "IsMasterProtein" "Q02750" "Dual specificity mitogen-activated protein kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP2K1 PE=1 SV=2" "0.000" "False" "13.509" "7" "3" "5" "3" "393" "43.4" "6.62" "16.21" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "5604" "ENSG00000169032" "MAP2K1" "hsa:5604; Q02750" "IL-5 signaling pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; Endothelin pathways; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Aryl hydrocarbon receptor pathway; Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; IL6 signaling pathway; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PDGFR-beta pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ethanol metabolism production of ROS by CYP2E1; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; GNAQ pathways in port-wine stain; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling; Toll-like receptor signaling pathway" "Signaling by BRAF and RAF1 fusions; Uptake and function of anthrax toxins; Signal transduction by L1; RAF activation; MAP3K8 (TPL2)-dependent MAPK1/3 activation; MAPK3 (ERK1) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Negative feedback regulation of MAPK pathway; Signaling by MAP2K mutants" "102" "0" "0.976" "1.064" "1.075" "1.033" "1.066" "0.930" "1.041" "0.923" "0.676" "603.7" "589.2" "642.0" "648.8" "623.8" "643.4" "561.7" "628.7" "557.1" "407.9" "" "" "" "" "" "" "" "" "" "" "319.6" "326.6" "367.7" "298.8" "337.5" "357.9" "330.6" "343.2" "312.5" "407.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8479423548841098522" "False" "High" "IsMasterProtein" "P21283" "V-type proton ATPase subunit C 1 OS=Homo sapiens OX=9606 GN=ATP6V1C1 PE=1 SV=4" "0.000" "False" "13.480" "11" "5" "6" "5" "382" "43.9" "7.46" "15.43" "5" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity" "Pf03223" "528" "ENSG00000155097" "ATP6V1C1" "hsa:528; P21283" "Proximal tubule transport" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "6" "0" "1.055" "1.002" "1.115" "1.084" "1.090" "1.112" "1.051" "1.038" "2.105" "446.1" "470.6" "447.0" "497.2" "483.8" "486.4" "495.9" "468.7" "463.3" "938.9" "" "" "" "" "" "" "" "" "" "" "236.2" "260.9" "256.0" "229.0" "261.7" "270.5" "291.9" "255.8" "259.9" "938.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-849081801659546262" "False" "High" "IsMasterProtein" "P30533" "Alpha-2-macroglobulin receptor-associated protein OS=Homo sapiens OX=9606 GN=LRPAP1 PE=1 SV=1" "0.000" "False" "13.463" "14" "6" "8" "6" "357" "41.4" "8.78" "21.42" "6" "transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf06400, Pf06401" "4043" "ENSG00000163956" "LRPAP1" "D3DVR9; hsa:4043; P30533; Q2M310; Q53HQ3; Q53HS6" "Cholesterol metabolism" "" "1" "0" "1.044" "1.110" "1.065" "1.014" "0.972" "1.093" "1.147" "1.045" "0.601" "683.5" "713.8" "758.8" "728.0" "693.2" "664.7" "746.8" "784.2" "714.0" "411.0" "" "" "" "" "" "" "" "" "" "" "361.9" "395.7" "434.5" "335.3" "375.1" "369.7" "439.5" "428.0" "400.6" "411.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2413702222549115072" "False" "High" "IsMasterProtein" "P13693" "Translationally-controlled tumor protein OS=Homo sapiens OX=9606 GN=TPT1 PE=1 SV=1" "0.000" "False" "13.451" "18" "4" "12" "4" "172" "19.6" "4.93" "28.02" "4" "transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00838" "7178" "ENSG00000133112" "TPT1" "B2R7E5; hsa:7178; P13693; Q6YLS2; Q7Z4J4; Q8TBK7; Q96EE2; Q9UC70" "" "" "0" "0" "1.030" "1.110" "1.024" "1.067" "1.071" "0.997" "1.219" "1.319" "0.776" "1240.4" "1277.4" "1377.1" "1270.5" "1323.9" "1328.9" "1237.0" "1511.5" "1636.3" "962.3" "" "" "" "" "" "" "" "" "" "" "656.8" "708.2" "788.7" "585.1" "716.3" "739.2" "728.0" "825.1" "917.9" "962.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8724268624419382152" "False" "High" "IsMasterProtein" "P50213" "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3A PE=1 SV=1" "0.000" "False" "13.429" "9" "4" "5" "4" "366" "39.6" "6.92" "15.08" "4" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00180" "3419" "ENSG00000166411" "IDH3A" "D3DW83; hsa:3419; P50213; Q9H3X0" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Metabolic reprogramming in colon cancer; TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "5" "0" "0.938" "0.818" "0.715" "0.791" "0.873" "0.717" "0.749" "0.865" "0.523" "492.7" "462.2" "402.9" "352.1" "389.7" "430.1" "353.5" "368.9" "426.0" "257.9" "" "" "" "" "" "" "" "" "" "" "260.9" "256.3" "230.7" "162.1" "210.9" "239.2" "208.1" "201.4" "239.0" "257.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8529586358305545684" "False" "High" "IsMasterProtein" "P04181" "Ornithine aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=OAT PE=1 SV=1" "0.000" "False" "13.417" "9" "4" "4" "4" "439" "48.5" "7.03" "9.93" "4" "other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00202" "4942" "ENSG00000065154" "OAT" "D3DRF0; hsa:4942; P04181; Q16068; Q16069; Q68CS0; Q6IAV9; Q9UD03" "Amino acid metabolism; 22q11.2 copy number variation syndrome; Creatine pathway" "Glutamate and glutamine metabolism" "4" "0" "1.035" "1.005" "1.084" "0.932" "0.924" "0.988" "0.964" "0.883" "0.797" "257.9" "266.8" "259.3" "279.5" "240.5" "238.4" "254.8" "248.5" "227.6" "205.6" "" "" "" "" "" "" "" "" "" "" "136.5" "147.9" "148.5" "128.7" "130.1" "132.6" "149.9" "135.7" "127.7" "205.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8561031833154832659" "False" "High" "IsMasterProtein" "O15379" "Histone deacetylase 3 OS=Homo sapiens OX=9606 GN=HDAC3 PE=1 SV=2" "0.000" "False" "13.414" "8" "4" "5" "3" "428" "48.8" "5.16" "15.05" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00850" "8841" "ENSG00000171720" "HDAC3" "D3DQE1; hsa:8841; O15379; O43268; Q9UEI5; Q9UEV0" "Neural crest differentiation; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Transcription co-factors SKI and SKIL protein partners; 22q11.2 copy number variation syndrome; IL-18 signaling pathway; 7q11.23 copy number variation syndrome; 16p11.2 proximal deletion syndrome" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Regulation of PTEN gene transcription; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Cytoprotection by HMOX1; Association of TriC/CCT with target proteins during biosynthesis; NR1D1 (REV-ERBA) represses gene expression; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX2 regulates osteoblast differentiation; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; STAT3 nuclear events downstream of ALK signaling" "31" "0" "1.046" "0.949" "1.140" "1.196" "1.056" "1.275" "1.255" "1.303" "1.420" "498.1" "521.0" "472.8" "568.0" "595.7" "525.8" "635.0" "625.2" "649.1" "707.4" "" "" "" "" "" "" "" "" "" "" "263.7" "288.9" "270.8" "261.6" "322.3" "292.5" "373.7" "341.3" "364.1" "707.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3128972635678329678" "False" "High" "IsMasterProtein" "Q9BUT1" "Dehydrogenase/reductase SDR family member 6 OS=Homo sapiens OX=9606 GN=BDH2 PE=1 SV=2" "0.000" "False" "13.397" "12" "3" "4" "3" "245" "26.7" "7.65" "11.47" "3" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13561" "56898" "ENSG00000164039" "BDH2" "A8K295; B4DUF6; hsa:56898; Q503A0; Q6IA46; Q6UWD3; Q9BUT1; Q9H8S8; Q9NRX8" "" "Synthesis of Ketone Bodies" "1" "0" "1.080" "1.074" "1.050" "1.269" "1.058" "1.194" "0.904" "0.748" "1.178" "83.5" "90.1" "89.7" "87.6" "106.0" "88.4" "99.6" "75.4" "62.5" "98.4" "" "" "" "" "" "" "" "" "" "" "44.2" "50.0" "51.3" "40.4" "57.3" "49.1" "58.6" "41.2" "35.0" "98.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1948602544583202968" "False" "High" "IsMasterProtein" "Q13042" "Cell division cycle protein 16 homolog OS=Homo sapiens OX=9606 GN=CDC16 PE=1 SV=2" "0.000" "False" "13.393" "6" "4" "4" "4" "620" "71.6" "5.85" "9.41" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf12895, Pf13424" "8881" "ENSG00000130177" "CDC16" "A2A365; hsa:8881; Q13042; Q5T8C8; Q7Z651; Q96AE6; Q9Y564" "Cell cycle" "Antigen processing: Ubiquitination & Proteasome degradation; Senescence-Associated Secretory Phenotype (SASP); APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "1.063" "1.215" "1.202" "1.202" "1.206" "1.109" "0.955" "1.053" "1.515" "95.1" "101.1" "115.6" "114.4" "114.3" "114.8" "105.5" "90.8" "100.2" "144.1" "" "" "" "" "" "" "" "" "" "" "50.4" "56.1" "66.2" "52.7" "61.8" "63.8" "62.1" "49.6" "56.2" "144.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2238397026184103268" "False" "High" "IsMasterProtein" "Q9ULU4" "MYND-type zinc finger-containing chromatin reader ZMYND8 OS=Homo sapiens OX=9606 GN=ZMYND8 PE=1 SV=2" "0.000" "False" "13.384" "4" "3" "4" "3" "1186" "131.6" "7.20" "9.03" "3" "cell organization and biogenesis;DNA metabolism;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00439, Pf00628, Pf00855, Pf12064" "23613" "ENSG00000101040" "ZMYND8" "B3KVL2; B7Z2A8; B7Z3E0; B7Z680; B7ZM62; E1P5U5; F5H0X3; H7C0U2; hsa:23613; J3KPU3; Q13517; Q2HXV1; Q2HXV2; Q2HXV3; Q2HXV4; Q2HXV7; Q2HXV8; Q2HXV9; Q2HXW0; Q2HXW1; Q2HXW2; Q4JJ94; Q4JJ95; Q5TH09; Q5TH11; Q6MZM1; Q8WXC5; Q9H1F3; Q9H1F4; Q9H1F5; Q9H1L8; Q9H1L9; Q9H2G5; Q9NYN3; Q9UIX6; Q9ULU4" "" "" "0" "0" "0.963" "0.886" "1.275" "1.210" "1.125" "2.502" "2.756" "2.783" "1.922" "80.9" "77.9" "71.7" "103.1" "97.8" "91.0" "202.3" "222.9" "225.1" "155.4" "" "" "" "" "" "" "" "" "" "" "42.8" "43.2" "41.1" "47.5" "52.9" "50.6" "119.1" "121.7" "126.3" "155.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7165899401853608207" "False" "High" "IsMasterProtein" "P04424" "Argininosuccinate lyase OS=Homo sapiens OX=9606 GN=ASL PE=1 SV=4" "0.000" "False" "13.374" "8" "4" "4" "4" "464" "51.6" "6.48" "8.83" "4" "other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00206, Pf14698" "435" "ENSG00000126522" "ASL" "E7EMI0; E9PE48; hsa:435; P04424; Q6LDS5; Q96HS2" "Alanine and aspartate metabolism" "Urea cycle" "2" "0" "0.976" "0.979" "0.982" "0.985" "1.059" "0.959" "1.042" "0.993" "0.751" "736.1" "718.5" "720.9" "722.8" "725.4" "779.8" "705.9" "767.4" "730.9" "552.8" "" "" "" "" "" "" "" "" "" "" "389.8" "398.4" "412.9" "332.9" "392.4" "433.8" "415.5" "418.9" "410.0" "552.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5067244968494119358" "False" "High" "IsMasterProtein" "O75496" "Geminin OS=Homo sapiens OX=9606 GN=GMNN PE=1 SV=1" "0.000" "False" "13.358" "15" "3" "3" "3" "209" "23.6" "4.96" "10.77" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07412" "51053" "ENSG00000112312" "GMNN" "B3KMM8; hsa:51053; O75496; Q9H1Z1" "DNA replication; DYRK1A involvement regarding cell proliferation in brain development" "Assembly of the pre-replicative complex; Activation of the pre-replicative complex; Switching of origins to a post-replicative state" "5" "0" "1.082" "1.101" "0.855" "1.112" "1.010" "0.849" "0.998" "1.106" "0.547" "478.4" "517.6" "526.8" "409.1" "532.0" "483.1" "406.4" "477.3" "529.3" "261.5" "" "" "" "" "" "" "" "" "" "" "253.3" "287.0" "301.7" "188.4" "287.8" "268.7" "239.2" "260.5" "296.9" "261.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1141422113329583141" "False" "High" "IsMasterProtein" "Q04446" "1,4-alpha-glucan-branching enzyme OS=Homo sapiens OX=9606 GN=GBE1 PE=1 SV=3" "0.000" "False" "13.335" "6" "5" "6" "5" "702" "80.4" "6.32" "17.39" "5" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00128, Pf02806, Pf02922" "2632" "ENSG00000114480" "GBE1" "B3KWV3; hsa:2632; Q04446; Q96EN0" "Glycogen synthesis and degradation; Disorders of galactose metabolism" "Glycogen synthesis; Glycogen storage disease type IV (GBE1)" "4" "0" "1.057" "0.993" "1.055" "0.993" "1.065" "1.086" "0.699" "1.037" "3.932" "404.1" "427.3" "401.4" "426.4" "401.1" "430.3" "438.9" "282.6" "418.9" "1589.0" "" "" "" "" "" "" "" "" "" "" "214.0" "236.9" "229.9" "196.4" "217.0" "239.3" "258.3" "154.2" "235.0" "1589.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4208729749156870383" "False" "High" "IsMasterProtein" "O60678" "Protein arginine N-methyltransferase 3 OS=Homo sapiens OX=9606 GN=PRMT3 PE=1 SV=4" "0.000" "False" "13.310" "6" "3" "3" "3" "531" "59.9" "5.35" "9.14" "3" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity;other molecular function" "Pf06325, Pf21137, Pf21336" "10196" "ENSG00000185238" "PRMT3" "A0A0A0MSN7; B4DUC7; hsa:10196; O60678" "Nitric oxide metabolism in cystic fibrosis" "RMTs methylate histone arginines; Protein methylation" "3" "0" "0.984" "0.977" "1.187" "1.105" "1.026" "1.076" "0.927" "0.952" "1.520" "292.2" "287.5" "285.6" "346.9" "322.8" "299.7" "314.5" "270.7" "278.0" "444.1" "" "" "" "" "" "" "" "" "" "" "154.7" "159.4" "163.6" "159.8" "174.6" "166.7" "185.1" "147.8" "156.0" "444.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-329240465840991374" "False" "High" "IsMasterProtein" "Q6GMV3" "Putative peptidyl-tRNA hydrolase PTRHD1 OS=Homo sapiens OX=9606 GN=PTRHD1 PE=1 SV=1" "0.000" "False" "13.289" "25" "3" "4" "3" "140" "15.8" "9.10" "14.71" "3" "" "" "other molecular function" "Pf01981" "391356" "ENSG00000184924" "PTRHD1" "Q6GMV3" "" "" "0" "0" "0.923" "1.006" "0.860" "0.896" "0.920" "0.879" "1.045" "0.895" "0.448" "470.5" "434.2" "473.2" "404.8" "421.8" "432.8" "413.6" "491.9" "421.2" "210.5" "" "" "" "" "" "" "" "" "" "" "249.1" "240.7" "271.0" "186.4" "228.2" "240.8" "243.4" "268.5" "236.3" "210.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8127348192762311520" "False" "High" "IsMasterProtein" "Q96HN2" "Adenosylhomocysteinase 3 OS=Homo sapiens OX=9606 GN=AHCYL2 PE=1 SV=1" "0.000" "False" "13.278" "6" "4" "8" "2" "611" "66.7" "7.36" "24.33" "4" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00670, Pf05221" "23382" "ENSG00000158467" "AHCYL2" "B4DIZ5; D9N155; hsa:23382; O94917; Q96HN2" "One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Spina bifida" "Bicarbonate transporters" "4" "1" "1.045" "1.050" "0.987" "1.023" "1.065" "0.897" "1.042" "0.972" "0.668" "357.8" "373.8" "375.7" "353.2" "366.0" "380.9" "321.1" "372.8" "347.6" "239.1" "" "" "" "" "" "" "" "" "" "" "189.5" "207.2" "215.2" "162.6" "198.0" "211.9" "189.0" "203.5" "195.0" "239.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-823041984393634953" "False" "High" "IsMasterProtein" "P25774" "Cathepsin S OS=Homo sapiens OX=9606 GN=CTSS PE=1 SV=3" "0.000" "False" "13.263" "9" "3" "4" "3" "331" "37.5" "8.34" "13.09" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00112, Pf08246" "1520" "ENSG00000163131" "CTSS" "B4DWC9; D3DV05; hsa:1520; P25774; Q5T5I0; Q6FHS5; Q9BUG3" "" "MHC class II antigen presentation; Neutrophil degranulation; Degradation of the extracellular matrix; Assembly of collagen fibrils and other multimeric structures; Trafficking and processing of endosomal TLR; Endosomal/Vacuolar pathway" "6" "0" "0.917" "1.008" "0.872" "0.976" "0.921" "0.895" "0.965" "0.833" "0.556" "1135.7" "1041.4" "1144.5" "990.0" "1108.8" "1046.1" "1016.2" "1095.6" "945.9" "631.8" "" "" "" "" "" "" "" "" "" "" "601.3" "577.4" "655.5" "455.9" "599.9" "581.9" "598.1" "598.0" "530.6" "631.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2244987817245821138" "False" "High" "IsMasterProtein" "Q14004" "Cyclin-dependent kinase 13 OS=Homo sapiens OX=9606 GN=CDK13 PE=1 SV=2" "0.000" "False" "13.238" "2" "3" "5" "2" "1512" "164.8" "9.69" "15.09" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "8621" "ENSG00000065883" "CDK13" "hsa:8621; Q14004; Q53G78; Q6DKQ9; Q75MH4; Q75MH5; Q96JN4; Q9H4A0; Q9H4A1; Q9UDR4" "" "Neutrophil degranulation; TP53 Regulates Transcription of DNA Repair Genes" "2" "0" "1.023" "1.079" "1.191" "1.222" "1.110" "1.185" "1.104" "1.252" "1.056" "167.4" "171.2" "180.6" "199.3" "204.5" "185.8" "198.4" "184.8" "209.6" "176.7" "" "" "" "" "" "" "" "" "" "" "88.6" "94.9" "103.4" "91.8" "110.7" "103.3" "116.7" "100.9" "117.6" "176.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7558389581764573434" "False" "High" "IsMasterProtein" "P18858" "DNA ligase 1 OS=Homo sapiens OX=9606 GN=LIG1 PE=1 SV=1" "0.000" "False" "13.234" "5" "5" "5" "5" "919" "101.7" "5.62" "9.42" "5" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01068, Pf04675, Pf04679" "3978" "ENSG00000105486" "LIG1" "B2RAI8; B4DTU4; hsa:3978; P18858; Q2TB12; Q32P23" "Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Gap-filling DNA repair synthesis and ligation in TC-NER; Early Phase of HIV Life Cycle; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Processive synthesis on the lagging strand; Gap-filling DNA repair synthesis and ligation in GG-NER; Processive synthesis on the C-strand of the telomere; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "14" "0" "0.934" "1.010" "0.928" "0.885" "0.884" "0.929" "0.698" "0.902" "3.262" "253.1" "236.3" "255.6" "234.9" "224.1" "223.7" "235.1" "176.7" "228.2" "825.5" "" "" "" "" "" "" "" "" "" "" "134.0" "131.0" "146.4" "108.2" "121.2" "124.4" "138.3" "96.5" "128.0" "825.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5604147819280005923" "False" "High" "IsMasterProtein" "P50613" "Cyclin-dependent kinase 7 OS=Homo sapiens OX=9606 GN=CDK7 PE=1 SV=1" "0.000" "False" "13.202" "6" "2" "4" "2" "346" "39.0" "8.47" "8.54" "2" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1022" "ENSG00000134058; ENSG00000277273" "CDK7" "hsa:1022; P50613; Q9BS60; Q9UE19" "MicroRNAs in cardiomyocyte hypertrophy; Cell cycle; Cardiac hypertrophic response; Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum" "NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "43" "0" "0.947" "1.010" "1.001" "1.025" "1.125" "0.983" "1.156" "1.079" "1.036" "274.7" "260.2" "277.6" "275.1" "281.6" "309.0" "270.0" "317.6" "296.4" "284.5" "" "" "" "" "" "" "" "" "" "" "145.5" "144.2" "159.0" "126.7" "152.4" "171.9" "158.9" "173.4" "166.3" "284.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1761258682097812184" "False" "High" "IsMasterProtein" "Q9NS86" "LanC-like protein 2 OS=Homo sapiens OX=9606 GN=LANCL2 PE=1 SV=1" "0.000" "False" "13.195" "6" "3" "3" "3" "450" "50.8" "7.43" "8.22" "3" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf05147" "55915" "ENSG00000132434" "LANCL2" "B2R8D4; hsa:55915; Q6NSL4; Q8TCQ3; Q9BSR1; Q9NS86" "" "" "0" "0" "1.095" "1.001" "1.046" "1.081" "0.992" "0.994" "1.063" "1.101" "0.773" "302.6" "331.3" "302.9" "316.4" "327.0" "300.3" "300.8" "321.6" "333.3" "233.9" "" "" "" "" "" "" "" "" "" "" "160.2" "183.7" "173.5" "145.7" "176.9" "167.0" "177.0" "175.5" "187.0" "233.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3819481250379265452" "False" "High" "IsMasterProtein" "Q5JWF2" "Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas OS=Homo sapiens OX=9606 GN=GNAS PE=1 SV=2" "0.000" "False" "13.191" "3" "4" "5" "3" "1037" "111.0" "5.03" "12.90" "4" "cell adhesion;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00503" "2778" "ENSG00000087460" "GNAS" "A2A2S3; E1P5G3; O75684; O75685; Q5JW67; Q5JWF1; Q5JWF2; Q9NY42" "Thyroid stimulating hormone (TSH) signaling pathway; Endothelin pathways; Corticotropin-releasing hormone signaling pathway; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; G protein signaling pathways; Thermogenesis; Hippo signaling regulation pathways; Purinergic signaling; GPR143 in melanocytes and retinal pigment epithelium cells; Vasopressin-regulated water reabsorption; Prostaglandin and leukotriene metabolism in senescence ; Primary ovarian insufficiency; Prostaglandin and leukotriene metabolism in senescence ; Calcium regulation in cardiac cells; Estrogen signaling pathway; Serotonin receptor 4/6/7 and NR3C signaling" "G alpha (i) signalling events; G alpha (z) signalling events; G alpha (s) signalling events; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Prostacyclin signalling through prostacyclin receptor; Glucagon-type ligand receptors; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation in glucagon signalling; Hedgehog 'off' state" "29" "0" "0.942" "1.055" "0.961" "0.616" "0.715" "0.543" "0.684" "0.535" "0.771" "39.6" "37.3" "41.8" "38.1" "24.4" "28.3" "21.5" "27.1" "21.2" "30.5" "" "" "" "" "" "" "" "" "" "" "21.0" "20.7" "23.9" "17.5" "13.2" "15.7" "12.7" "14.8" "11.9" "30.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "316205606070741097" "False" "High" "IsMasterProtein" "Q5JTD0" "Tight junction-associated protein 1 OS=Homo sapiens OX=9606 GN=TJAP1 PE=1 SV=1" "0.000" "False" "13.189" "8" "4" "4" "4" "557" "61.8" "5.97" "10.64" "4" "cell organization and biogenesis" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf15453" "93643" "ENSG00000137221" "TJAP1" "hsa:93643; Q05BH9; Q5JTD0; Q5JTD1; Q5JWW1; Q68DB2; Q6P2P3; Q9H7V7" "" "" "0" "0" "1.026" "0.991" "1.110" "1.060" "0.982" "1.090" "1.063" "0.928" "1.084" "177.2" "181.9" "175.7" "196.7" "187.8" "174.0" "193.2" "188.4" "164.4" "192.2" "" "" "" "" "" "" "" "" "" "" "93.8" "100.9" "100.6" "90.6" "101.6" "96.8" "113.7" "102.8" "92.2" "192.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4378027519318782833" "False" "High" "IsMasterProtein" "Q9H425" "Uncharacterized protein C1orf198 OS=Homo sapiens OX=9606 GN=C1orf198 PE=1 SV=1" "0.000" "False" "13.186" "10" "3" "3" "3" "327" "36.3" "5.72" "7.78" "3" "" "cytosol" "" "Pf15797" "84886" "ENSG00000119280" "C1orf198" "A8K8R8; B3KTW1; G5EA08; hsa:84886; Q9H425" "" "" "0" "0" "1.000" "1.012" "0.982" "1.091" "1.030" "0.949" "1.018" "1.051" "0.916" "369.4" "369.6" "374.0" "362.9" "402.9" "380.4" "350.6" "376.2" "388.4" "338.4" "" "" "" "" "" "" "" "" "" "" "195.6" "204.9" "214.2" "167.1" "218.0" "211.6" "206.3" "205.3" "217.9" "338.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9165342661713370894" "False" "High" "IsMasterProtein" "Q969U7" "Proteasome assembly chaperone 2 OS=Homo sapiens OX=9606 GN=PSMG2 PE=1 SV=1" "0.000" "False" "13.178" "16" "6" "10" "6" "264" "29.4" "6.98" "15.54" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf09754" "56984" "ENSG00000128789" "PSMG2" "B0YJB3; hsa:56984; Q6IAH4; Q969U7; Q9NRV1; V9GYH7" "" "" "0" "0" "1.091" "0.937" "0.987" "1.027" "1.117" "0.983" "1.087" "1.016" "0.613" "416.3" "454.2" "390.2" "410.8" "427.6" "465.1" "409.1" "452.3" "422.9" "255.3" "" "" "" "" "" "" "" "" "" "" "220.4" "251.8" "223.5" "189.2" "231.4" "258.7" "240.8" "246.9" "237.3" "255.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6108137657648573585" "False" "High" "IsMasterProtein" "O95571" "Persulfide dioxygenase ETHE1, mitochondrial OS=Homo sapiens OX=9606 GN=ETHE1 PE=1 SV=2" "0.000" "False" "13.175" "9" "2" "5" "2" "254" "27.9" "6.83" "13.32" "2" "other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00753" "23474" "ENSG00000105755" "ETHE1" "hsa:23474; O95571; Q96HR0; Q9H001" "" "Sulfide oxidation to sulfate" "1" "0" "1.190" "1.046" "1.240" "1.145" "1.071" "1.198" "1.093" "1.041" "0.654" "201.5" "239.8" "210.8" "249.8" "230.7" "215.8" "241.3" "220.2" "209.7" "131.7" "" "" "" "" "" "" "" "" "" "" "106.7" "132.9" "120.7" "115.0" "124.8" "120.0" "142.0" "120.2" "117.6" "131.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5230612763215460817" "False" "High" "IsMasterProtein" "Q99829" "Copine-1 OS=Homo sapiens OX=9606 GN=CPNE1 PE=1 SV=1" "0.000" "False" "13.161" "9" "6" "11" "6" "537" "59.0" "5.83" "26.90" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf07002" "8904" "ENSG00000214078" "CPNE1" "E1P5Q4; hsa:8904; Q6IBL3; Q99829; Q9H243; Q9NTZ7" "" "Neutrophil degranulation; Glycerophospholipid biosynthesis" "2" "0" "0.966" "0.985" "1.006" "1.057" "1.047" "1.004" "0.922" "0.942" "0.968" "1420.7" "1372.2" "1399.9" "1428.7" "1502.4" "1487.3" "1426.0" "1310.1" "1338.2" "1374.7" "" "" "" "" "" "" "" "" "" "" "752.3" "760.8" "801.7" "658.0" "812.9" "827.3" "839.3" "715.1" "750.7" "1374.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6026735558710273601" "False" "High" "IsMasterProtein" "P36507" "Dual specificity mitogen-activated protein kinase kinase 2 OS=Homo sapiens OX=9606 GN=MAP2K2 PE=1 SV=1" "0.000" "False" "13.156" "9" "4" "5" "4" "400" "44.4" "6.55" "13.98" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "5605" "ENSG00000126934" "MAP2K2" "hsa:5605; P36507" "IL-5 signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Amyotrophic lateral sclerosis (ALS); Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Bladder cancer; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; IL6 signaling pathway; Pathways affected in adenoid cystic carcinoma; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ethanol metabolism production of ROS by CYP2E1; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Kallmann syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; GNAQ pathways in port-wine stain; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling; Toll-like receptor signaling pathway" "Signaling by BRAF and RAF1 fusions; Uptake and function of anthrax toxins; Signal transduction by L1; RAF activation; MAPK1 (ERK2) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Negative feedback regulation of MAPK pathway; Signaling by MAP2K mutants" "88" "0" "1.018" "0.927" "0.942" "0.977" "0.946" "0.898" "0.929" "1.037" "0.729" "259.9" "264.6" "240.9" "244.8" "253.9" "245.7" "233.4" "241.4" "269.6" "189.5" "" "" "" "" "" "" "" "" "" "" "137.6" "146.7" "138.0" "112.7" "137.4" "136.7" "137.4" "131.8" "151.2" "189.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "997292728151378108" "False" "High" "IsMasterProtein" "P32519" "ETS-related transcription factor Elf-1 OS=Homo sapiens OX=9606 GN=ELF1 PE=1 SV=2" "0.000" "False" "13.112" "6" "3" "3" "3" "619" "67.5" "5.21" "9.67" "3" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf12310" "1997" "ENSG00000120690" "ELF1" "B4E2I5; E9PDQ9; hsa:1997; P32519; Q8N6F6; Q9UDE1" "" "RUNX1 regulates transcription of genes involved in interleukin signaling; RUNX1 regulates transcription of genes involved in BCR signaling" "2" "0" "0.854" "0.826" "0.835" "0.953" "0.831" "0.972" "0.651" "0.800" "3.997" "172.9" "147.6" "142.8" "144.4" "164.8" "143.6" "168.0" "112.5" "138.2" "691.1" "" "" "" "" "" "" "" "" "" "" "91.5" "81.9" "81.8" "66.5" "89.1" "79.9" "98.9" "61.4" "77.5" "691.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "562653879591220854" "False" "High" "IsMasterProtein" "P09488" "Glutathione S-transferase Mu 1 OS=Homo sapiens OX=9606 GN=GSTM1 PE=1 SV=3" "0.000" "False" "13.105" "15" "3" "6" "1" "218" "25.7" "6.70" "14.41" "3" "other metabolic processes;stress response" "cytosol;other cell component" "other molecular function" "Pf00043, Pf02798" "2944" "ENSG00000134184" "GSTM1" "hsa:2944; P09488; Q5GHG0; Q6FH88; Q8TC98; Q9UC96" "Glutathione metabolism; Nuclear receptors meta-pathway; NRF2 pathway; Benzene metabolism; Estrogen metabolism; Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II" "Paracetamol ADME; Glutathione conjugation; Azathioprine ADME" "10" "2" "1.000" "0.963" "0.918" "0.974" "1.095" "0.859" "0.780" "0.862" "1.590" "274.0" "273.9" "263.9" "251.5" "267.0" "300.2" "235.3" "213.7" "236.3" "435.8" "" "" "" "" "" "" "" "" "" "" "145.1" "151.9" "151.1" "115.8" "144.5" "167.0" "138.5" "116.6" "132.6" "435.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6326411103029325143" "False" "High" "IsMasterProtein" "P53602" "Diphosphomevalonate decarboxylase OS=Homo sapiens OX=9606 GN=MVD PE=1 SV=1" "0.000" "False" "13.064" "9" "4" "5" "4" "400" "43.4" "7.23" "13.94" "4" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00288, Pf18376" "4597" "ENSG00000167508" "MVD" "P53602; Q53Y65" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Mevalonate pathway; Aspirin and miRNAs; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis; Synthesis of Dolichyl-phosphate" "11" "0" "0.960" "0.914" "1.180" "1.057" "1.120" "1.099" "1.017" "0.971" "0.831" "248.3" "238.3" "227.1" "292.9" "262.4" "278.1" "273.0" "252.6" "241.2" "206.4" "" "" "" "" "" "" "" "" "" "" "131.5" "132.1" "130.0" "134.9" "142.0" "154.7" "160.7" "137.9" "135.3" "206.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4838480320139969571" "False" "High" "IsMasterProtein" "Q13951" "Core-binding factor subunit beta OS=Homo sapiens OX=9606 GN=CBFB PE=1 SV=2" "0.000" "False" "13.059" "13" "2" "4" "2" "182" "21.5" "6.60" "14.65" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf02312" "865" "ENSG00000067955" "CBFB" "A8K347; hsa:865; Q13124; Q13951; Q9HCT2" "Dual hijack model of Vif in HIV infection; Hijack of ubiquitination by SARS-CoV-2" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of RUNX3 expression and activity; RUNX2 regulates osteoblast differentiation; Transcriptional regulation of granulopoiesis; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Estrogen-dependent gene expression; RUNX1 regulates expression of components of tight junctions; RUNX1 regulates transcription of genes involved in differentiation of keratinocytes; RUNX1 regulates estrogen receptor mediated transcription; RUNX1 regulates transcription of genes involved in WNT signaling; RUNX2 regulates genes involved in cell migration; RUNX3 regulates p14-ARF; RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs); RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; RUNX1 regulates transcription of genes involved in interleukin signaling; RUNX2 regulates chondrocyte maturation; RUNX3 Regulates Immune Response and Cell Migration; Regulation of RUNX1 Expression and Activity; RUNX2 regulates genes involved in differentiation of myeloid cells; RUNX1 regulates transcription of genes involved in BCR signaling; RUNX3 regulates RUNX1-mediated transcription" "27" "0" "1.013" "0.946" "1.058" "0.980" "0.952" "1.032" "0.942" "0.986" "1.871" "374.7" "379.5" "354.6" "396.5" "367.0" "356.7" "386.5" "353.1" "369.2" "701.0" "" "" "" "" "" "" "" "" "" "" "198.4" "210.4" "203.1" "182.6" "198.6" "198.4" "227.5" "192.7" "207.1" "701.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1056370544189754053" "False" "High" "IsMasterProtein" "P28065" "Proteasome subunit beta type-9 OS=Homo sapiens OX=9606 GN=PSMB9 PE=1 SV=2" "0.000" "False" "13.056" "16" "4" "7" "4" "219" "23.3" "5.03" "20.67" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227" "5698" "ENSG00000239836; ENSG00000240065; ENSG00000240118; ENSG00000240508; ENSG00000242711; ENSG00000243067; ENSG00000243594; ENSG00000243958" "PSMB9" "B0V0T1; hsa:5698; P28065; Q16523; Q5JNW4" "Proteasome degradation; Type II interferon signaling" "Separation of Sister Chromatids; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Downstream TCR signaling; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "61" "0" "1.006" "0.933" "1.029" "0.991" "1.016" "1.114" "1.029" "1.051" "0.589" "826.9" "832.3" "771.5" "850.8" "819.3" "840.0" "921.2" "851.1" "868.8" "486.9" "" "" "" "" "" "" "" "" "" "" "437.8" "461.4" "441.9" "391.8" "443.3" "467.2" "542.2" "464.6" "487.4" "486.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1054037842820128470" "False" "High" "IsMasterProtein" "Q9BXK1" "Krueppel-like factor 16 OS=Homo sapiens OX=9606 GN=KLF16 PE=1 SV=1" "0.000" "False" "13.055" "10" "1" "1" "1" "252" "25.4" "9.88" "6.79" "1" "signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "83855" "ENSG00000129911" "KLF16" "hsa:83855; Q9BXK1" "" "" "0" "0" "0.959" "1.252" "1.212" "0.937" "1.196" "1.172" "1.258" "1.067" "1.774" "20.1" "19.2" "25.1" "24.3" "18.8" "24.0" "23.5" "25.2" "21.4" "35.6" "" "" "" "" "" "" "" "" "" "" "10.6" "10.7" "14.4" "11.2" "10.2" "13.3" "13.8" "13.8" "12.0" "35.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8489357358395881882" "False" "High" "IsMasterProtein" "Q86SX6" "Glutaredoxin-related protein 5, mitochondrial OS=Homo sapiens OX=9606 GN=GLRX5 PE=1 SV=2" "0.000" "False" "13.051" "16" "2" "4" "2" "157" "16.6" "6.79" "11.99" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00462" "51218" "ENSG00000182512" "GLRX5" "hsa:51218; Q0X088; Q3YML0; Q86SX6; Q86WY3; Q8IZ54" "Iron-sulfur cluster biogenesis" "Mitochondrial iron-sulfur cluster biogenesis" "2" "0" "1.129" "1.108" "1.496" "1.224" "1.052" "1.261" "1.118" "1.021" "0.856" "220.7" "249.2" "244.5" "330.1" "270.2" "232.1" "278.3" "246.7" "225.3" "189.0" "" "" "" "" "" "" "" "" "" "" "116.8" "138.2" "140.0" "152.0" "146.2" "129.1" "163.8" "134.7" "126.4" "189.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5585916410181359903" "False" "High" "IsMasterProtein" "Q6IQ49" "Splicing regulator SDE2 OS=Homo sapiens OX=9606 GN=SDE2 PE=1 SV=1" "0.000" "False" "13.043" "11" "4" "4" "4" "451" "49.7" "6.05" "11.39" "4" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf13019, Pf13297" "163859" "ENSG00000143751" "SDE2" "A8K4P3; hsa:163859; Q5TD36; Q6IQ49; Q6ZS26; Q8NAG7" "" "mRNA Splicing - Major Pathway" "1" "0" "1.139" "1.154" "1.229" "1.286" "1.142" "1.284" "1.325" "1.108" "0.914" "97.1" "110.6" "112.1" "119.4" "124.9" "110.9" "124.7" "128.7" "107.6" "88.8" "" "" "" "" "" "" "" "" "" "" "51.4" "61.3" "64.2" "55.0" "67.6" "61.7" "73.4" "70.2" "60.4" "88.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6076185631256904569" "False" "High" "IsMasterProtein" "Q9P016" "Thymocyte nuclear protein 1 OS=Homo sapiens OX=9606 GN=THYN1 PE=1 SV=1" "0.000" "False" "13.028" "15" "4" "6" "4" "225" "25.7" "9.25" "15.33" "4" "" "" "" "Pf01878" "29087" "ENSG00000151500" "THYN1" "hsa:29087; Q567Q2; Q9H3L4; Q9HC20; Q9P016" "" "" "0" "0" "0.921" "0.985" "0.872" "0.900" "0.951" "0.880" "0.835" "0.860" "0.847" "732.8" "675.0" "721.9" "639.1" "659.6" "697.3" "645.0" "612.3" "630.0" "620.9" "" "" "" "" "" "" "" "" "" "" "388.0" "374.2" "413.4" "294.3" "356.9" "387.8" "379.6" "334.2" "353.4" "620.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4655798141038654615" "False" "High" "IsMasterProtein" "Q8N6N3" "UPF0690 protein C1orf52 OS=Homo sapiens OX=9606 GN=C1orf52 PE=1 SV=1" "0.000" "False" "13.026" "21" "4" "4" "4" "182" "20.6" "5.21" "12.04" "4" "" "nucleus" "" "Pf15559" "148423" "ENSG00000162642" "C1orf52" "B3KX89; hsa:148423; Q8N6N3; Q8TDK5; Q8TDK6" "" "" "0" "0" "0.916" "0.985" "0.968" "0.893" "0.812" "0.843" "0.945" "0.846" "0.500" "711.8" "651.7" "701.2" "688.7" "635.6" "577.8" "600.3" "672.9" "602.0" "355.7" "" "" "" "" "" "" "" "" "" "" "376.9" "361.3" "401.6" "317.2" "343.9" "321.4" "353.3" "367.3" "337.7" "355.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8196142567442196869" "False" "High" "IsMasterProtein" "P20645" "Cation-dependent mannose-6-phosphate receptor OS=Homo sapiens OX=9606 GN=M6PR PE=1 SV=1" "0.000" "False" "13.016" "13" "2" "2" "2" "277" "31.0" "5.83" "7.71" "2" "transport" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02157" "4074" "ENSG00000003056" "M6PR" "A8K528; D3DUV5; hsa:4074; P20645" "" "Glycosphingolipid catabolism; Retrograde transport at the Trans-Golgi-Network; Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis" "5" "0" "1.090" "0.858" "1.181" "1.107" "1.004" "1.091" "0.983" "1.106" "1.010" "154.3" "168.1" "132.5" "182.2" "170.8" "155.0" "168.4" "151.6" "170.7" "155.9" "" "" "" "" "" "" "" "" "" "" "81.7" "93.2" "75.9" "83.9" "92.4" "86.2" "99.1" "82.8" "95.7" "155.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9201428938326541883" "False" "High" "IsMasterProtein" "Q15291" "Retinoblastoma-binding protein 5 OS=Homo sapiens OX=9606 GN=RBBP5 PE=1 SV=2" "0.000" "False" "13.014" "6" "3" "4" "3" "538" "59.1" "5.10" "7.53" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00400" "5929" "ENSG00000117222" "RBBP5" "A8K272; hsa:5929; Q15291; Q7Z6D8; Q8NDZ7" "Kleefstra syndrome" "Neddylation; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Formation of WDR5-containing histone-modifying complexes; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "8" "0" "1.067" "0.939" "1.031" "1.075" "1.048" "1.047" "0.956" "1.155" "0.963" "165.2" "176.2" "155.1" "170.3" "177.6" "173.1" "172.9" "158.0" "190.8" "159.1" "" "" "" "" "" "" "" "" "" "" "87.5" "97.7" "88.8" "78.4" "96.1" "96.3" "101.7" "86.2" "107.1" "159.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "217416082876923675" "False" "High" "IsMasterProtein" "O75410" "Transforming acidic coiled-coil-containing protein 1 OS=Homo sapiens OX=9606 GN=TACC1 PE=1 SV=2" "0.000" "False" "13.011" "4" "3" "3" "3" "805" "87.7" "4.88" "9.66" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05010" "6867" "ENSG00000147526" "TACC1" "B2RBD9; B4E302; D3DSX6; hsa:6867; O75410; Q6Y687; Q86YG7; Q8IUJ2; Q8IUJ3; Q8IUJ4; Q8IZG2; Q8NEY7; Q9UPP9" "" "" "0" "0" "1.124" "1.042" "1.122" "1.055" "1.096" "1.151" "1.218" "1.124" "0.755" "373.7" "420.1" "389.2" "419.3" "394.3" "409.6" "430.2" "455.1" "419.9" "282.2" "" "" "" "" "" "" "" "" "" "" "197.9" "232.9" "222.9" "193.1" "213.3" "227.9" "253.2" "248.4" "235.6" "282.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6836769617334137947" "False" "High" "IsMasterProtein" "Q96LA8" "Protein arginine N-methyltransferase 6 OS=Homo sapiens OX=9606 GN=PRMT6 PE=1 SV=1" "0.000" "False" "12.994" "7" "2" "2" "2" "375" "41.9" "5.44" "8.82" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf13649" "55170" "ENSG00000198890" "PRMT6" "A3KME1; B4DID8; hsa:55170; Q5T5Y5; Q6DKI4; Q96LA8; Q9NVR8" "Male infertility; Nitric oxide metabolism in cystic fibrosis" "RMTs methylate histone arginines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "4" "0" "1.122" "0.989" "1.188" "1.040" "0.968" "1.109" "0.855" "1.001" "0.790" "283.0" "317.6" "279.9" "336.2" "294.4" "273.8" "313.8" "241.9" "283.3" "223.6" "" "" "" "" "" "" "" "" "" "" "149.8" "176.1" "160.3" "154.9" "159.3" "152.3" "184.7" "132.1" "158.9" "223.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3341461915485741514" "False" "High" "IsMasterProtein" "Q9HC36" "rRNA methyltransferase 3, mitochondrial OS=Homo sapiens OX=9606 GN=MRM3 PE=1 SV=2" "0.000" "False" "12.986" "7" "4" "4" "4" "420" "47.0" "8.73" "13.11" "4" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00588" "55178" "ENSG00000171861" "MRM3" "hsa:55178; Q53GN1; Q86VC3; Q96F76; Q9HC36; Q9NVQ5" "" "rRNA modification in the mitochondrion" "1" "0" "1.132" "1.039" "1.045" "1.178" "1.187" "1.191" "1.115" "1.183" "1.026" "381.1" "431.5" "395.9" "398.3" "448.8" "452.5" "453.8" "424.8" "450.7" "391.0" "" "" "" "" "" "" "" "" "" "" "201.8" "239.2" "226.7" "183.4" "242.8" "251.7" "267.1" "231.9" "252.8" "391.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7576876112341409561" "False" "High" "IsMasterProtein" "O43813" "Glutathione S-transferase LANCL1 OS=Homo sapiens OX=9606 GN=LANCL1 PE=1 SV=1" "0.000" "False" "12.956" "11" "4" "6" "4" "399" "45.3" "7.75" "11.71" "4" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05147" "10314" "ENSG00000115365" "LANCL1" "hsa:10314; O43813" "" "" "0" "0" "1.050" "1.108" "1.044" "1.030" "1.094" "1.007" "1.167" "1.057" "0.721" "303.8" "319.1" "336.6" "317.3" "313.1" "332.4" "305.9" "354.5" "321.2" "219.2" "" "" "" "" "" "" "" "" "" "" "160.9" "176.9" "192.8" "146.1" "169.4" "184.9" "180.0" "193.5" "180.2" "219.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4447457189107336251" "False" "High" "IsMasterProtein" "O60493" "Sorting nexin-3 OS=Homo sapiens OX=9606 GN=SNX3 PE=1 SV=3" "0.000" "False" "12.919" "21" "3" "3" "2" "162" "18.8" "8.66" "8.87" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00787" "8724" "ENSG00000112335" "SNX3" "A8K0B1; E1P5E4; E1P5E5; hsa:8724; O60493; O60718; Q4TT29; Q4TT31; Q5JXJ7; Q5JXJ8; Q96AP9; Q9C0J5; Q9NU45" "" "Ub-specific processing proteases; WNT ligand biogenesis and trafficking" "2" "0" "1.311" "1.124" "1.303" "1.163" "1.004" "1.072" "0.959" "1.053" "2.526" "143.1" "187.6" "160.8" "186.4" "166.4" "143.7" "153.4" "137.2" "150.7" "361.4" "" "" "" "" "" "" "" "" "" "" "75.8" "104.0" "92.1" "85.8" "90.1" "79.9" "90.3" "74.9" "84.5" "361.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3992202401745413050" "False" "High" "IsMasterProtein" "O75044" "SLIT-ROBO Rho GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=SRGAP2 PE=1 SV=3" "0.000" "False" "12.917" "3" "4" "5" "4" "1071" "120.8" "6.70" "14.39" "4" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00611, Pf00620" "23380" "ENSG00000266028" "SRGAP2" "A2RUF3; hsa:23380; O75044" "" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases Activate Formins; RAC3 GTPase cycle; RHOF GTPase cycle; RHOU GTPase cycle; Inactivation of CDC42 and RAC1" "8" "0" "1.065" "0.936" "1.036" "1.102" "0.997" "1.082" "1.062" "1.035" "1.365" "208.9" "222.5" "195.5" "216.4" "230.2" "208.2" "226.1" "221.9" "216.2" "285.2" "" "" "" "" "" "" "" "" "" "" "110.6" "123.4" "112.0" "99.6" "124.6" "115.8" "133.1" "121.1" "121.3" "285.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-390863097898701106" "False" "High" "IsMasterProtein" "Q14657" "EKC/KEOPS complex subunit LAGE3 OS=Homo sapiens OX=9606 GN=LAGE3 PE=1 SV=2" "0.000" "False" "12.911" "21" "2" "4" "2" "143" "14.8" "8.63" "17.45" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf09341" "8270" "ENSG00000196976" "LAGE3" "hsa:8270; Q14657; Q5HY39; Q8IZ78" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.957" "0.943" "0.840" "0.889" "0.930" "0.908" "0.763" "0.815" "0.456" "88.1" "84.3" "83.1" "74.0" "78.4" "81.9" "80.0" "67.2" "71.8" "40.2" "" "" "" "" "" "" "" "" "" "" "46.6" "46.8" "47.6" "34.1" "42.4" "45.6" "47.1" "36.7" "40.3" "40.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8651766820472939276" "False" "High" "IsMasterProtein" "Q12792" "Twinfilin-1 OS=Homo sapiens OX=9606 GN=TWF1 PE=1 SV=3" "0.000" "False" "12.902" "13" "5" "5" "4" "350" "40.3" "6.96" "12.08" "5" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "5756" "ENSG00000151239" "TWF1" "A8K5A8; B3KXS6; B4DLX9; hsa:5756; Q12792; Q59G07; Q5U0B1; Q6FHJ1; Q6FHL6; Q6NUK9; Q86XL6; Q8TCD3" "" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHOBTB2 GTPase cycle" "3" "0" "1.068" "0.910" "0.905" "0.957" "0.944" "1.010" "1.004" "0.997" "0.569" "496.3" "529.9" "451.6" "449.3" "475.0" "468.6" "501.3" "498.4" "494.6" "282.4" "" "" "" "" "" "" "" "" "" "" "262.8" "293.8" "258.6" "206.9" "257.0" "260.7" "295.0" "272.0" "277.5" "282.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5632561991288096733" "False" "High" "IsMasterProtein" "Q9H9Y6" "DNA-directed RNA polymerase I subunit RPA2 OS=Homo sapiens OX=9606 GN=POLR1B PE=1 SV=2" "0.000" "False" "12.900" "3" "3" "3" "3" "1135" "128.1" "7.83" "9.50" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf06883" "84172" "ENSG00000125630" "POLR1B" "B7Z6Y7; B7Z823; F5GZX4; F8W898; hsa:84172; Q2TAM4; Q585T5; Q6ZRR2; Q9H9D3; Q9H9Y6" "Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "8" "0" "1.249" "1.064" "1.058" "1.016" "1.294" "1.136" "0.917" "1.709" "3.841" "272.1" "340.0" "289.5" "287.9" "276.5" "352.0" "309.2" "249.6" "465.1" "1045.3" "" "" "" "" "" "" "" "" "" "" "144.1" "188.5" "165.8" "132.6" "149.6" "195.8" "182.0" "136.3" "260.9" "1045.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4248741172720899665" "False" "High" "IsMasterProtein" "P62304" "Small nuclear ribonucleoprotein E OS=Homo sapiens OX=9606 GN=SNRPE PE=1 SV=1" "0.000" "False" "12.881" "25" "2" "7" "2" "92" "10.8" "9.44" "14.84" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "6635" "ENSG00000182004" "SNRPE" "B2R5B9; hsa:6635; P08578; P62304; Q15498; Q5BKT2" "mRNA processing" "snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "8" "0" "0.970" "1.055" "1.233" "1.196" "1.063" "1.260" "0.938" "0.936" "0.657" "59.7" "57.9" "62.9" "73.6" "71.3" "63.4" "75.2" "56.0" "55.9" "39.2" "" "" "" "" "" "" "" "" "" "" "31.6" "32.1" "36.0" "33.9" "38.6" "35.3" "44.2" "30.6" "31.3" "39.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7629412907813045008" "False" "High" "IsMasterProtein" "Q14997" "Proteasome activator complex subunit 4 OS=Homo sapiens OX=9606 GN=PSME4 PE=1 SV=2" "0.000" "False" "12.875" "2" "4" "5" "4" "1843" "211.2" "6.90" "13.40" "4" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf11919, Pf16507" "23198" "ENSG00000068878" "PSME4" "hsa:23198; Q14997; Q1XBG4; Q1XBG5; Q1XBG6; Q2M1Z0; Q6IPR2; Q86XF8" "" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway" "52" "0" "1.090" "0.975" "0.972" "1.054" "1.063" "1.084" "1.104" "1.007" "0.827" "437.3" "476.4" "426.3" "425.1" "460.8" "464.9" "474.1" "482.6" "440.4" "361.7" "" "" "" "" "" "" "" "" "" "" "231.5" "264.2" "244.1" "195.8" "249.3" "258.6" "279.0" "263.4" "247.1" "361.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3857525489381916364" "False" "High" "IsMasterProtein" "A8MXV4" "Acyl-coenzyme A diphosphatase NUDT19 OS=Homo sapiens OX=9606 GN=NUDT19 PE=1 SV=1" "0.000" "False" "12.863" "9" "3" "5" "3" "375" "42.2" "7.64" "13.06" "3" "other metabolic processes" "cytosol;other cytoplasmic organelle" "other molecular function" "" "390916" "ENSG00000213965" "NUDT19" "A8MXV4; hsa:390916" "" "Peroxisomal lipid metabolism; Peroxisomal protein import" "2" "0" "0.994" "0.945" "0.953" "0.953" "0.945" "1.002" "0.938" "0.948" "0.774" "493.3" "490.4" "466.1" "470.2" "470.0" "466.1" "494.1" "462.7" "467.6" "381.8" "" "" "" "" "" "" "" "" "" "" "261.2" "271.9" "267.0" "216.5" "254.3" "259.3" "290.8" "252.6" "262.3" "381.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8973056022317677667" "False" "High" "IsMasterProtein" "Q9BVS4" "Serine/threonine-protein kinase RIO2 OS=Homo sapiens OX=9606 GN=RIOK2 PE=1 SV=2" "0.000" "False" "12.861" "4" "2" "2" "2" "552" "63.2" "5.94" "7.20" "2" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf01163, Pf09202" "55781" "ENSG00000058729" "RIOK2" "D6RDI3; hsa:55781; Q9BVS4; Q9NUT0" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.032" "1.110" "1.138" "1.094" "1.112" "0.947" "1.016" "1.016" "0.525" "330.1" "340.6" "366.6" "375.5" "361.0" "367.1" "312.6" "335.5" "335.4" "173.3" "" "" "" "" "" "" "" "" "" "" "174.8" "188.9" "209.9" "173.0" "195.3" "204.2" "183.9" "183.1" "188.2" "173.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "715968340642640214" "False" "High" "IsMasterProtein" "Q9H9A6" "Leucine-rich repeat-containing protein 40 OS=Homo sapiens OX=9606 GN=LRRC40 PE=1 SV=1" "0.000" "False" "12.861" "7" "5" "5" "5" "602" "68.2" "6.43" "12.85" "5" "signal transduction" "" "" "Pf00560, Pf13855" "55631" "ENSG00000066557" "LRRC40" "hsa:55631; Q9BTR7; Q9H9A6; Q9NSK1; Q9NXC1" "" "" "0" "0" "0.858" "0.825" "0.783" "0.895" "0.905" "0.841" "0.403" "0.858" "6.343" "329.5" "282.8" "271.8" "258.0" "295.1" "298.2" "277.2" "132.9" "282.8" "2090.0" "" "" "" "" "" "" "" "" "" "" "174.5" "156.8" "155.7" "118.8" "159.6" "165.8" "163.2" "72.6" "158.7" "2090.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1594484432885072185" "False" "High" "IsMasterProtein" "O75663" "TIP41-like protein OS=Homo sapiens OX=9606 GN=TIPRL PE=1 SV=2" "0.000" "False" "12.854" "7" "2" "4" "2" "272" "31.4" "5.91" "11.68" "2" "stress response;signal transduction;other biological processes" "cytosol" "" "Pf04176" "261726" "ENSG00000143155" "TIPRL" "B2R8V3; hsa:261726; O75663; Q5HYB2; Q8IZ86" "Ciliary landscape" "" "1" "0" "0.966" "1.038" "0.999" "1.013" "0.993" "1.010" "1.025" "1.037" "1.703" "497.3" "480.4" "516.0" "496.7" "504.0" "493.8" "502.2" "509.8" "515.7" "846.7" "" "" "" "" "" "" "" "" "" "" "263.3" "266.4" "295.5" "228.7" "272.7" "274.6" "295.6" "278.3" "289.3" "846.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4424001123554839232" "False" "High" "IsMasterProtein" "Q96CW1" "AP-2 complex subunit mu OS=Homo sapiens OX=9606 GN=AP2M1 PE=1 SV=2" "0.000" "False" "12.853" "9" "5" "10" "5" "435" "49.6" "9.54" "26.73" "5" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00928, Pf01217" "1173" "ENSG00000161203" "AP2M1" "A6NE12; D3DNT1; hsa:1173; P20172; P53679; Q96CW1" "Synaptic vesicle pathway; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; GDNF signaling" "Recycling pathway of L1; MHC class II antigen presentation; EPH-ephrin mediated repulsion of cells; Cargo recognition for clathrin-mediated endocytosis; VLDLR internalisation and degradation; Potential therapeutics for SARS; WNT5A-dependent internalization of FZD4; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Nef mediated downregulation of CD28 cell surface expression; Formation of annular gap junctions" "21" "0" "1.028" "0.968" "0.970" "1.033" "1.016" "1.036" "1.102" "1.117" "0.816" "998.5" "1026.7" "967.1" "968.4" "1031.0" "1014.2" "1034.5" "1100.1" "1115.8" "815.2" "" "" "" "" "" "" "" "" "" "" "528.7" "569.2" "553.8" "446.0" "557.8" "564.1" "608.9" "600.5" "626.0" "815.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7328219287373480262" "False" "High" "IsMasterProtein" "Q7LG56" "Ribonucleoside-diphosphate reductase subunit M2 B OS=Homo sapiens OX=9606 GN=RRM2B PE=1 SV=1" "0.000" "False" "12.805" "8" "3" "5" "2" "351" "40.7" "4.97" "17.00" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00268" "50484" "ENSG00000048392" "RRM2B" "B4E2N4; hsa:50484; Q17R22; Q75PQ6; Q75PQ7; Q75PY8; Q75PY9; Q7LG56; Q86YE3; Q9NPD6; Q9NTD8; Q9NUW3" "miRNA regulation of DNA damage response; Pyrimidine metabolism; p53 transcriptional gene network; DNA damage response" "Interconversion of nucleotide di- and triphosphates; TP53 Regulates Metabolic Genes" "6" "0" "0.951" "0.935" "0.918" "1.017" "1.000" "0.972" "1.014" "0.930" "0.622" "481.6" "458.0" "450.5" "442.1" "489.9" "481.4" "468.0" "488.3" "447.8" "299.4" "" "" "" "" "" "" "" "" "" "" "255.0" "253.9" "258.0" "203.6" "265.1" "267.8" "275.4" "266.5" "251.2" "299.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "222321955828462706" "False" "High" "IsMasterProtein" "O00244" "Copper transport protein ATOX1 OS=Homo sapiens OX=9606 GN=ATOX1 PE=1 SV=1" "0.000" "False" "12.800" "50" "3" "7" "3" "68" "7.4" "7.24" "14.22" "3" "stress response;transport;other biological processes" "cytosol" "other molecular function" "Pf00403" "475" "ENSG00000177556" "ATOX1" "A8KAJ8; D3DQI2; hsa:475; O00244; Q2M1R6; Q56AP3" "Copper homeostasis" "Detoxification of Reactive Oxygen Species; Ion influx/efflux at host-pathogen interface" "3" "0" "0.846" "1.001" "1.032" "1.026" "0.867" "0.894" "0.874" "0.869" "0.503" "152.7" "129.2" "152.7" "157.6" "156.7" "132.3" "136.4" "133.4" "132.7" "76.8" "" "" "" "" "" "" "" "" "" "" "80.8" "71.6" "87.5" "72.6" "84.8" "73.6" "80.3" "72.8" "74.4" "76.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5891546535660205639" "False" "High" "IsMasterProtein" "Q6P1X6" "UPF0598 protein C8orf82 OS=Homo sapiens OX=9606 GN=C8orf82 PE=1 SV=2" "0.000" "False" "12.789" "16" "3" "4" "3" "216" "23.9" "9.14" "12.36" "3" "" "" "" "Pf14956" "414919" "ENSG00000213563" "C8orf82" "hsa:414919; Q6GMR2; Q6P1X6; Q6P2Q7" "" "" "0" "0" "1.350" "1.218" "1.214" "1.208" "1.285" "1.172" "1.048" "1.166" "0.942" "117.2" "158.2" "142.8" "142.3" "141.5" "150.6" "137.4" "122.8" "136.7" "110.4" "" "" "" "" "" "" "" "" "" "" "62.1" "87.7" "81.8" "65.5" "76.6" "83.8" "80.9" "67.0" "76.7" "110.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6271968905262141895" "False" "High" "IsMasterProtein" "Q4VC31" "Protein MIX23 OS=Homo sapiens OX=9606 GN=MIX23 PE=1 SV=1" "0.000" "False" "12.787" "17" "2" "4" "2" "144" "16.6" "7.81" "16.09" "2" "" "mitochondrion" "" "Pf09774" "131076" "ENSG00000160124" "MIX23" "hsa:131076; Q32LY6; Q4VC31" "" "" "0" "0" "0.963" "1.175" "0.957" "0.953" "0.897" "0.914" "1.044" "1.056" "0.428" "800.5" "771.3" "940.2" "766.0" "763.2" "718.0" "731.3" "835.9" "845.4" "343.0" "" "" "" "" "" "" "" "" "" "" "423.9" "427.6" "538.5" "352.7" "412.9" "399.4" "430.4" "456.3" "474.3" "343.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1949176893953303809" "False" "High" "IsMasterProtein" "Q9NZZ3" "Charged multivesicular body protein 5 OS=Homo sapiens OX=9606 GN=CHMP5 PE=1 SV=1" "0.000" "False" "12.776" "18" "3" "5" "3" "219" "24.6" "4.83" "12.57" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf03357" "51510" "ENSG00000086065" "CHMP5" "B2RD95; B4DIR6; hsa:51510; Q5VXW2; Q96AV2; Q9HB68; Q9NYS4; Q9NZZ3; Q9Y323" "Ferroptosis" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)" "3" "0" "1.301" "1.217" "1.452" "1.047" "1.132" "1.360" "1.169" "1.378" "1.170" "61.0" "79.3" "74.3" "88.6" "63.9" "69.1" "83.0" "71.3" "84.1" "71.4" "" "" "" "" "" "" "" "" "" "" "32.3" "44.0" "42.5" "40.8" "34.5" "38.4" "48.8" "38.9" "47.2" "71.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6956886752181187117" "False" "High" "IsMasterProtein" "P55039" "Developmentally-regulated GTP-binding protein 2 OS=Homo sapiens OX=9606 GN=DRG2 PE=1 SV=1" "0.000" "False" "12.762" "11" "4" "5" "3" "364" "40.7" "8.88" "15.29" "4" "protein metabolism;other metabolic processes;signal transduction" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01926, Pf02824, Pf16897" "1819" "ENSG00000108591" "DRG2" "B2R8G5; hsa:1819; P55039; Q53Y50; Q9BWB2" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Protein hydroxylation" "2" "0" "1.079" "1.038" "1.135" "1.122" "1.094" "1.077" "1.034" "0.968" "1.233" "283.4" "305.9" "294.0" "321.6" "317.8" "309.9" "305.3" "293.0" "274.4" "349.4" "" "" "" "" "" "" "" "" "" "" "150.0" "169.6" "168.4" "148.1" "172.0" "172.4" "179.7" "159.9" "153.9" "349.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4314325281228425264" "False" "High" "IsMasterProtein" "O15382" "Branched-chain-amino-acid aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=BCAT2 PE=1 SV=2" "0.000" "False" "12.762" "8" "2" "2" "2" "392" "44.3" "8.65" "9.03" "2" "other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf01063" "587" "ENSG00000105552" "BCAT2" "B2RB87; hsa:587; O00269; O15382; Q96KG1; Q9BTB6; Q9BUU6" "Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways" "Branched-chain amino acid catabolism" "3" "0" "1.003" "0.798" "1.258" "0.956" "0.924" "0.869" "0.867" "0.711" "0.662" "41.8" "41.9" "33.3" "52.6" "39.9" "38.6" "36.3" "36.2" "29.7" "27.6" "" "" "" "" "" "" "" "" "" "" "22.1" "23.2" "19.1" "24.2" "21.6" "21.5" "21.4" "19.8" "16.7" "27.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6425786624467733847" "False" "High" "IsMasterProtein" "O95758" "Polypyrimidine tract-binding protein 3 OS=Homo sapiens OX=9606 GN=PTBP3 PE=1 SV=2" "0.000" "False" "12.758" "9" "6" "12" "3" "552" "59.7" "9.04" "25.58" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf11835, Pf13893" "9991" "ENSG00000119314" "PTBP3" "B1ALY2; B1ALY3; B1ALY5; B1ALY6; B3KME7; hsa:9991; O95758; Q68DB9; Q86YB3; Q86YH9" "" "" "0" "0" "1.111" "1.178" "1.311" "1.144" "1.132" "1.125" "0.697" "1.203" "7.372" "116.8" "129.7" "137.6" "153.1" "133.6" "132.2" "131.4" "81.4" "140.5" "861.1" "" "" "" "" "" "" "" "" "" "" "61.9" "71.9" "78.8" "70.5" "72.3" "73.5" "77.4" "44.5" "78.8" "861.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6460055541994458794" "False" "High" "IsMasterProtein" "Q14019" "Coactosin-like protein OS=Homo sapiens OX=9606 GN=COTL1 PE=1 SV=3" "0.000" "False" "12.758" "20" "4" "7" "4" "142" "15.9" "5.67" "16.26" "4" "cell organization and biogenesis;stress response" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "23406" "ENSG00000103187" "COTL1" "B2RDU3; D3DUL9; hsa:23406; Q14019; Q86XM5" "" "Neutrophil degranulation" "1" "0" "0.989" "0.999" "0.965" "1.023" "0.929" "0.963" "1.015" "0.916" "0.650" "636.5" "629.6" "635.8" "614.4" "651.0" "591.6" "612.8" "646.3" "583.4" "413.7" "" "" "" "" "" "" "" "" "" "" "337.0" "349.1" "364.1" "283.0" "352.2" "329.1" "360.6" "352.8" "327.2" "413.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5713044218766232811" "False" "High" "IsMasterProtein" "Q9NXR7" "BRISC and BRCA1-A complex member 2 OS=Homo sapiens OX=9606 GN=BABAM2 PE=1 SV=2" "0.000" "False" "12.751" "8" "3" "5" "3" "383" "43.5" "5.81" "8.46" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf06113" "9577" "ENSG00000158019" "BABAM2" "A8K4X1; D6W562; D6W563; hsa:9577; Q13880; Q4ZFX8; Q53SD0; Q969X9; Q96P06; Q9NXR7" "5q35 copy number variation" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs" "6" "0" "0.962" "1.054" "1.003" "1.053" "1.047" "1.051" "1.121" "0.998" "0.732" "454.7" "437.3" "479.3" "456.3" "478.9" "476.2" "478.2" "509.7" "453.9" "333.0" "" "" "" "" "" "" "" "" "" "" "240.8" "242.5" "274.5" "210.1" "259.1" "264.9" "281.4" "278.2" "254.6" "333.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-320392191251803943" "False" "High" "IsMasterProtein" "Q9BXS6" "Nucleolar and spindle-associated protein 1 OS=Homo sapiens OX=9606 GN=NUSAP1 PE=1 SV=1" "0.000" "False" "12.746" "8" "3" "4" "3" "441" "49.4" "9.91" "11.75" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity" "Pf16006" "51203" "ENSG00000137804" "NUSAP1" "B4DDF1; E7ERR5; hsa:51203; J3KN21; Q53GW2; Q8TBT4; Q96E58; Q96FJ1; Q9BXS6; Q9GZM9; Q9NZ85; Q9UI70" "" "" "0" "0" "1.095" "1.097" "1.004" "1.032" "1.007" "0.956" "1.004" "0.970" "0.986" "427.2" "467.6" "468.9" "428.8" "440.7" "430.3" "408.5" "429.1" "414.3" "421.4" "" "" "" "" "" "" "" "" "" "" "226.2" "259.3" "268.5" "197.5" "238.4" "239.4" "240.4" "234.2" "232.4" "421.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "123318016964233677" "False" "High" "IsMasterProtein" "O75489" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS3 PE=1 SV=1" "0.000" "False" "12.703" "13" "3" "4" "3" "264" "30.2" "7.50" "11.38" "3" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion;nucleus" "transporter activity;other molecular function" "Pf00329" "4722" "ENSG00000213619" "NDUFS3" "B2R9J1; B4DFM8; hsa:4722; O75489; Q9UNQ8" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "RHOG GTPase cycle; Complex I biogenesis; Mitochondrial protein degradation" "7" "0" "1.034" "1.053" "1.145" "1.078" "1.068" "1.002" "1.065" "1.063" "0.930" "332.8" "344.0" "350.4" "380.9" "358.8" "355.3" "333.4" "354.4" "353.9" "309.3" "" "" "" "" "" "" "" "" "" "" "176.2" "190.7" "200.7" "175.4" "194.1" "197.7" "196.2" "193.4" "198.5" "309.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9200930033631648957" "False" "High" "IsMasterProtein" "Q06413" "Myocyte-specific enhancer factor 2C OS=Homo sapiens OX=9606 GN=MEF2C PE=1 SV=1" "0.000" "False" "12.694" "7" "3" "3" "1" "473" "51.2" "8.03" "9.49" "3" "cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319, Pf12347" "4208" "ENSG00000081189" "MEF2C" "C9JMZ0; D7F7N5; F8W7V7; hsa:4208; Q06413" "Energy metabolism; Heart development; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; B cell receptor signaling pathway; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; MECP2 and associated Rett syndrome; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Prion disease pathway; Rett syndrome; EGF/EGFR signaling pathway; Gastrin signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; GDNF signaling; 2q37 copy number variation syndrome; Neurogenesis regulation in the olfactory epithelium; Sudden infant death syndrome (SIDS) susceptibility pathways" "ERK/MAPK targets; Heme signaling; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; Myogenesis; Cardiogenesis; MECP2 regulates transcription factors" "30" "0" "0.982" "0.938" "1.264" "1.055" "1.058" "1.137" "1.002" "0.925" "0.920" "232.7" "228.6" "218.3" "294.1" "245.6" "246.4" "264.6" "233.2" "215.3" "214.1" "" "" "" "" "" "" "" "" "" "" "123.2" "126.7" "125.0" "135.4" "132.9" "137.0" "155.7" "127.3" "120.8" "214.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3425744660855709231" "False" "High" "IsMasterProtein" "O60568" "Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 OS=Homo sapiens OX=9606 GN=PLOD3 PE=1 SV=1" "0.000" "False" "12.669" "5" "4" "4" "4" "738" "84.7" "6.05" "11.88" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;other membranes;ER/Golgi" "other molecular function" "Pf03171" "8985" "ENSG00000106397" "PLOD3" "B2R6W6; hsa:8985; O60568; Q540C3" "VEGFA-VEGFR2 signaling; IL-18 signaling pathway" "Collagen biosynthesis and modifying enzymes" "3" "0" "1.037" "0.995" "0.969" "1.071" "1.018" "0.984" "1.049" "1.008" "1.031" "646.0" "670.2" "642.9" "626.3" "691.6" "657.9" "635.9" "677.5" "651.0" "666.1" "" "" "" "" "" "" "" "" "" "" "342.1" "371.6" "368.2" "288.4" "374.2" "366.0" "374.2" "369.8" "365.2" "666.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5390020710088679993" "False" "High" "IsMasterProtein" "O75368" "Adapter SH3BGRL OS=Homo sapiens OX=9606 GN=SH3BGRL PE=1 SV=1" "0.000" "False" "12.630" "23" "3" "6" "3" "114" "12.8" "5.25" "17.94" "3" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf04908" "6451" "ENSG00000131171" "SH3BGRL" "hsa:6451; O75368; Q3SYL1; Q5JT50; Q6FIE8; Q9H0N8" "" "" "0" "0" "0.946" "1.044" "0.855" "0.860" "0.833" "0.873" "0.869" "0.845" "0.457" "1132.0" "1071.1" "1182.0" "968.3" "973.1" "943.0" "988.2" "983.9" "956.3" "517.7" "" "" "" "" "" "" "" "" "" "" "599.4" "593.8" "676.9" "445.9" "526.5" "524.6" "581.6" "537.1" "536.5" "517.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3076278996676727483" "False" "High" "IsMasterProtein" "P53350" "Serine/threonine-protein kinase PLK1 OS=Homo sapiens OX=9606 GN=PLK1 PE=1 SV=1" "0.000" "False" "12.623" "9" "6" "7" "6" "603" "68.2" "8.91" "20.11" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00659" "5347" "ENSG00000166851" "PLK1" "hsa:5347; P53350; Q15153; Q99746" "Cell cycle; Integrated cancer pathway; Androgen receptor network in prostate cancer; TNF-alpha signaling pathway; 22q11.2 copy number variation syndrome; Cohesin complex - Cornelia de Lange syndrome" "The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; Regulation of PLK1 Activity at G2/M Transition; Phosphorylation of the APC/C; Cyclin A/B1/B2 associated events during G2/M transition; Golgi Cisternae Pericentriolar Stack Reorganization; Condensation of Prophase Chromosomes; Polo-like kinase mediated events; Activation of NIMA Kinases NEK9, NEK6, NEK7; Phosphorylation of Emi1; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Mitotic Telophase/Cytokinesis; Mitotic Metaphase/Anaphase Transition" "30" "0" "1.130" "1.053" "1.179" "1.150" "1.125" "1.038" "0.970" "0.958" "0.882" "598.9" "676.8" "630.4" "705.9" "688.9" "673.9" "621.7" "581.0" "573.5" "528.4" "" "" "" "" "" "" "" "" "" "" "317.1" "375.2" "361.0" "325.1" "372.7" "374.9" "365.9" "317.1" "321.7" "528.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5453029631849906368" "False" "High" "IsMasterProtein" "Q9NRN7" "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase OS=Homo sapiens OX=9606 GN=AASDHPPT PE=1 SV=2" "0.000" "False" "12.598" "10" "3" "4" "3" "309" "35.8" "6.80" "10.42" "3" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf01648" "60496" "ENSG00000149313" "AASDHPPT" "B2R6D1; B4DDW7; hsa:60496; Q9C068; Q9NRN7; Q9P0Q3; Q9UG80; Q9Y389" "" "Vitamin B5 (pantothenate) metabolism" "1" "0" "0.952" "0.939" "0.950" "0.972" "0.918" "1.054" "1.081" "0.880" "0.735" "429.7" "409.2" "403.4" "408.1" "417.7" "394.5" "452.7" "464.4" "378.0" "315.7" "" "" "" "" "" "" "" "" "" "" "227.5" "226.9" "231.0" "188.0" "226.0" "219.4" "266.5" "253.5" "212.1" "315.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4306142825200876867" "False" "High" "IsMasterProtein" "P11766" "Alcohol dehydrogenase class-3 OS=Homo sapiens OX=9606 GN=ADH5 PE=1 SV=4" "0.000" "False" "12.593" "11" "5" "11" "5" "374" "39.7" "7.49" "28.81" "5" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf00107, Pf08240" "128" "ENSG00000197894" "ADH5" "hsa:128; P11766; Q6FHR2" "Folate-alcohol and cancer pathway hypotheses; Amino acid metabolism" "Ethanol oxidation" "3" "0" "0.902" "0.931" "0.913" "0.941" "0.994" "0.877" "0.885" "0.931" "0.555" "1803.6" "1626.6" "1678.9" "1646.3" "1696.4" "1793.6" "1582.3" "1595.7" "1678.5" "1000.2" "" "" "" "" "" "" "" "" "" "" "955.0" "901.8" "961.5" "758.2" "917.8" "997.7" "931.2" "871.0" "941.6" "1000.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6199563702112544119" "False" "High" "IsMasterProtein" "Q86XP3" "ATP-dependent RNA helicase DDX42 OS=Homo sapiens OX=9606 GN=DDX42 PE=1 SV=1" "0.000" "False" "12.592" "4" "4" "6" "4" "938" "102.9" "7.02" "14.89" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "11325" "ENSG00000198231" "DDX42" "A6NML1; A8KA43; hsa:11325; O75619; Q68G51; Q86XP3; Q96BK1; Q96HR7; Q9Y3V8" "" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "2" "0" "0.774" "0.935" "1.091" "1.076" "0.669" "0.817" "0.389" "0.933" "6.388" "42.8" "33.1" "40.0" "46.7" "46.0" "28.6" "34.9" "16.6" "39.9" "273.4" "" "" "" "" "" "" "" "" "" "" "22.7" "18.4" "22.9" "21.5" "24.9" "15.9" "20.6" "9.1" "22.4" "273.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1264593624988505849" "False" "High" "IsMasterProtein" "Q14694" "Ubiquitin carboxyl-terminal hydrolase 10 OS=Homo sapiens OX=9606 GN=USP10 PE=1 SV=2" "0.000" "False" "12.564" "7" "5" "5" "5" "798" "87.1" "5.31" "14.61" "5" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00443, Pf07145" "9100" "ENSG00000103194" "USP10" "B2RDJ8; B4DS84; hsa:9100; Q14694; Q9BWG7; Q9NSL7" "VEGFA-VEGFR2 signaling" "Ub-specific processing proteases; Termination of translesion DNA synthesis" "3" "0" "0.992" "1.037" "0.973" "1.076" "1.164" "1.072" "1.128" "1.143" "1.537" "689.1" "683.7" "714.8" "670.7" "741.3" "802.3" "738.8" "777.5" "787.4" "1058.9" "" "" "" "" "" "" "" "" "" "" "364.9" "379.0" "409.4" "308.9" "401.1" "446.3" "434.8" "424.4" "441.7" "1058.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8769135798573244061" "False" "High" "IsMasterProtein" "P35658" "Nuclear pore complex protein Nup214 OS=Homo sapiens OX=9606 GN=NUP214 PE=1 SV=2" "0.000" "False" "12.545" "2" "5" "5" "5" "2090" "213.5" "7.47" "13.83" "5" "other metabolic processes;transport;other biological processes" "cytosol;nucleus" "other molecular function" "Pf18617" "8021" "ENSG00000126883" "NUP214" "A6NFQ0; hsa:8021; P35658; Q15010; Q3KQZ0; Q5JUP7; Q75R47; Q86XD3" "TGF-beta signaling pathway" "SUMOylation of DNA replication proteins; HCMV Early Events; Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HuR (ELAVL1) binds and stabilizes mRNA" "30" "0" "1.022" "1.025" "1.008" "1.082" "1.041" "1.009" "0.882" "1.062" "2.238" "640.6" "654.6" "656.7" "645.4" "693.0" "666.5" "646.4" "565.2" "680.2" "1433.4" "" "" "" "" "" "" "" "" "" "" "339.2" "362.9" "376.1" "297.2" "375.0" "370.8" "380.4" "308.5" "381.6" "1433.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5142432278754861003" "False" "High" "IsMasterProtein" "Q5TEC6" "Histone H3-7 OS=Homo sapiens OX=9606 GN=H3-7 PE=1 SV=1" "0.000" "False" "12.540" "26" "5" "11" "3" "136" "15.4" "11.27" "29.57" "5" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "" "ENSG00000273213" "H3-7" "Q5TEC6" "" "" "0" "2" "1.001" "1.002" "1.316" "1.074" "1.097" "1.022" "1.013" "0.976" "0.917" "595.1" "595.9" "596.2" "783.4" "639.3" "652.8" "608.0" "602.8" "580.7" "545.7" "" "" "" "" "" "" "" "" "" "" "315.1" "330.4" "341.5" "360.8" "345.9" "363.1" "357.9" "329.0" "325.8" "545.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1220366376593556815" "False" "High" "IsMasterProtein" "Q9Y5U2" "U5 small nuclear ribonucleoprotein TSSC4 OS=Homo sapiens OX=9606 GN=TSSC4 PE=1 SV=3" "0.000" "False" "12.535" "12" "4" "6" "4" "329" "34.3" "5.19" "16.59" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf15264" "10078" "ENSG00000184281" "TSSC4" "C9JS66; hsa:10078; Q86VL2; Q9BRS6; Q9Y5U2" "" "" "0" "0" "1.208" "1.106" "1.152" "1.160" "1.047" "1.103" "1.097" "1.273" "1.718" "157.9" "190.8" "174.6" "181.9" "183.1" "165.4" "174.3" "173.3" "201.0" "271.4" "" "" "" "" "" "" "" "" "" "" "83.6" "105.8" "100.0" "83.8" "99.1" "92.0" "102.6" "94.6" "112.7" "271.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4634668291009869452" "False" "High" "IsMasterProtein" "Q9UNP9" "Peptidyl-prolyl cis-trans isomerase E OS=Homo sapiens OX=9606 GN=PPIE PE=1 SV=1" "0.000" "False" "12.523" "14" "4" "4" "4" "301" "33.4" "5.60" "7.82" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00160" "10450" "ENSG00000084072" "PPIE" "B2R971; hsa:10450; O43634; O43635; Q32Q72; Q3S611; Q5TGA0; Q5TGA2; Q5TGA3; Q9UIZ5; Q9UNP9" "" "mRNA Splicing - Major Pathway; Neutrophil degranulation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "6" "0" "1.039" "1.100" "0.980" "1.126" "1.030" "1.007" "1.090" "1.263" "1.022" "511.8" "531.8" "562.9" "501.7" "576.3" "527.2" "515.7" "557.8" "646.6" "523.2" "" "" "" "" "" "" "" "" "" "" "271.0" "294.8" "322.4" "231.1" "311.8" "293.2" "303.5" "304.5" "362.7" "523.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4678846149867540289" "False" "High" "IsMasterProtein" "Q9H4A4" "Aminopeptidase B OS=Homo sapiens OX=9606 GN=RNPEP PE=1 SV=2" "0.000" "False" "12.518" "4" "2" "3" "2" "650" "72.5" "5.74" "11.14" "2" "protein metabolism" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "Pf01433, Pf09127, Pf17900" "6051" "ENSG00000176393" "RNPEP" "hsa:6051; Q9BVM9; Q9H1D4; Q9H4A4; Q9NPT7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3114131480513419355" "False" "High" "IsMasterProtein" "P62701" "Small ribosomal subunit protein eS4, X isoform OS=Homo sapiens OX=9606 GN=RPS4X PE=1 SV=2" "0.000" "False" "12.514" "12" "4" "5" "4" "263" "29.6" "10.15" "14.18" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00467, Pf00900, Pf08071, Pf16121" "6191" "ENSG00000198034" "RPS4X" "hsa:6191; P12631; P12750; P27576; P55831; P62701; Q14727; Q6IPY4" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "19" "0" "1.074" "1.006" "1.278" "1.128" "1.192" "1.191" "1.189" "1.336" "1.263" "534.4" "574.2" "537.8" "682.7" "602.8" "636.8" "636.6" "635.3" "714.2" "675.1" "" "" "" "" "" "" "" "" "" "" "283.0" "318.3" "308.0" "314.4" "326.1" "354.2" "374.7" "346.8" "400.6" "675.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-994823259514569156" "False" "High" "IsMasterProtein" "Q96I59" "Asparaginyl-tRNA synthetase OS=Homo sapiens OX=9606 GN=NARS2 PE=1 SV=3" "0.000" "False" "12.506" "7" "4" "4" "4" "477" "54.1" "7.24" "11.45" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00152, Pf01336" "79731" "ENSG00000137513" "NARS2" "G3V178; hsa:79731; Q96I59" "Ectoderm differentiation" "Mitochondrial tRNA aminoacylation" "2" "0" "1.028" "0.997" "1.199" "1.142" "1.098" "0.966" "1.009" "0.938" "1.021" "426.2" "438.0" "425.1" "510.9" "486.7" "468.1" "412.0" "430.1" "400.0" "435.1" "" "" "" "" "" "" "" "" "" "" "225.7" "242.9" "243.5" "235.3" "263.3" "260.4" "242.4" "234.8" "224.4" "435.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3906185605223521012" "False" "High" "IsMasterProtein" "Q9BY32" "Inosine triphosphate pyrophosphatase OS=Homo sapiens OX=9606 GN=ITPA PE=1 SV=2" "0.000" "False" "12.505" "13" "2" "3" "2" "194" "21.4" "5.66" "10.19" "2" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01725" "3704" "ENSG00000125877" "ITPA" "A2A2N2; A4UIM5; B2BCH7; hsa:3704; O14878; Q5JWH4; Q9BY32; Q9BYN1; Q9BYX0; Q9H3H8" "" "Purine catabolism; Ribavirin ADME" "2" "0" "0.928" "0.884" "0.967" "0.951" "0.972" "0.881" "0.943" "0.784" "0.466" "258.7" "240.2" "228.7" "250.3" "246.2" "251.3" "227.9" "244.0" "202.8" "120.7" "" "" "" "" "" "" "" "" "" "" "137.0" "133.2" "131.0" "115.3" "133.2" "139.8" "134.1" "133.2" "113.8" "120.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3787459776374465912" "False" "High" "IsMasterProtein" "Q9Y5L0" "Transportin-3 OS=Homo sapiens OX=9606 GN=TNPO3 PE=1 SV=3" "0.000" "False" "12.500" "3" "3" "4" "3" "923" "104.1" "5.57" "9.96" "3" "transport" "other membranes;nucleus;other cell component" "other molecular function" "Pf08389" "23534" "ENSG00000064419" "TNPO3" "A4D1K9; C9IZM0; hsa:23534; Q6NUM1; Q96G71; Q96GU9; Q9Y3R2; Q9Y5L0" "" "" "0" "0" "1.065" "1.045" "1.036" "1.040" "1.073" "1.064" "1.036" "0.981" "1.488" "219.9" "234.3" "229.8" "228.0" "228.7" "236.0" "234.1" "227.8" "215.7" "327.2" "" "" "" "" "" "" "" "" "" "" "116.5" "129.9" "131.6" "105.0" "123.7" "131.3" "137.8" "124.3" "121.0" "327.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4534228375388649933" "False" "High" "IsMasterProtein" "P52948" "Nuclear pore complex protein Nup98-Nup96 OS=Homo sapiens OX=9606 GN=NUP98 PE=1 SV=4" "0.000" "False" "12.480" "2" "4" "5" "4" "1817" "197.5" "6.40" "7.94" "4" "cell organization and biogenesis;protein metabolism;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04096, Pf12110, Pf21240" "4928" "ENSG00000110713" "NUP98" "hsa:4928; P52948; Q8IUT2; Q8WYB0; Q96E54; Q9H3Q4; Q9NT02; Q9UF57; Q9UHX0; Q9Y6J4; Q9Y6J5" "SARS-CoV-2 innate immunity evasion and cell-specific immune response" "" "1" "0" "1.047" "1.041" "1.037" "0.992" "0.979" "0.848" "0.667" "0.824" "1.799" "205.1" "214.8" "213.5" "212.8" "203.4" "200.8" "173.9" "136.8" "169.0" "368.9" "" "" "" "" "" "" "" "" "" "" "108.6" "119.1" "122.3" "98.0" "110.1" "111.7" "102.3" "74.6" "94.8" "368.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5022575274388480768" "False" "High" "IsMasterProtein" "P28161" "Glutathione S-transferase Mu 2 OS=Homo sapiens OX=9606 GN=GSTM2 PE=1 SV=2" "0.000" "False" "12.479" "17" "3" "6" "1" "218" "25.7" "6.37" "11.43" "3" "other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00043, Pf02798" "2946" "ENSG00000213366" "GSTM2" "B4DRY4; E9PEM9; hsa:2946; P28161; Q2M318; Q5TZY5; Q8WWE1" "Glutathione metabolism; Nuclear receptors meta-pathway; NRF2 pathway; FOXA2 pathway; Metapathway biotransformation Phase I and II" "Glutathione conjugation" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-547053484993874983" "False" "High" "IsMasterProtein" "Q13085" "Acetyl-CoA carboxylase 1 OS=Homo sapiens OX=9606 GN=ACACA PE=1 SV=2" "0.000" "False" "12.470" "2" "6" "6" "6" "2346" "265.4" "6.37" "11.70" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus" "other molecular function" "Pf00289, Pf00364, Pf01039, Pf02785, Pf02786, Pf08326, Pf21385" "31" "ENSG00000275176; ENSG00000278540" "ACACA" "B2RP68; B2ZZ90; hsa:31; Q13085; Q6KEV6; Q6XDA8; Q7Z2G8; Q7Z561; Q7Z563; Q7Z564; Q86WB2; Q86WB3" "AMP-activated protein kinase signaling; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; Corticotropin-releasing hormone signaling pathway; Mesodermal commitment pathway; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin and adiponectin; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Hereditary leiomyomatosis and renal cell carcinoma pathway; Mitochondrial fatty acid synthesis pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; 7q11.23 copy number variation syndrome; 17q12 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; ADHD and autism (ASD) linked metabolic pathways and SNP" "ChREBP activates metabolic gene expression; Biotin transport and metabolism; Carnitine metabolism; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; Defective HLCS causes multiple carboxylase deficiency" "24" "0" "0.966" "0.932" "1.049" "1.041" "0.712" "0.988" "0.537" "0.656" "3.011" "45.8" "44.2" "42.6" "48.0" "47.6" "32.6" "45.2" "24.6" "30.0" "137.7" "" "" "" "" "" "" "" "" "" "" "24.2" "24.5" "24.4" "22.1" "25.8" "18.1" "26.6" "13.4" "16.8" "137.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3265471816786777464" "False" "High" "IsMasterProtein" "Q9Y657" "Spindlin-1 OS=Homo sapiens OX=9606 GN=SPIN1 PE=1 SV=3" "0.000" "False" "12.467" "13" "3" "5" "3" "262" "29.6" "6.96" "12.64" "3" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf02513" "10927" "ENSG00000106723" "SPIN1" "A8K0X6; B3KRQ4; hsa:10927; Q7KZJ8; Q9GZT2; Q9H0N7; Q9Y657" "" "" "0" "0" "0.995" "0.993" "1.145" "1.072" "1.050" "1.091" "0.828" "1.080" "0.938" "92.1" "91.6" "91.5" "105.5" "98.7" "96.7" "100.5" "76.2" "99.5" "86.4" "" "" "" "" "" "" "" "" "" "" "48.8" "50.8" "52.4" "48.6" "53.4" "53.8" "59.2" "41.6" "55.8" "86.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7874915043186486884" "False" "High" "IsMasterProtein" "P20962" "Parathymosin OS=Homo sapiens OX=9606 GN=PTMS PE=1 SV=2" "0.000" "False" "12.449" "11" "1" "2" "1" "102" "11.5" "4.16" "6.92" "1" "DNA metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf03247" "5763" "ENSG00000159335" "PTMS" "hsa:5763; P20962" "IL-18 signaling pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2750317325017084074" "False" "High" "IsMasterProtein" "Q12962" "Transcription initiation factor TFIID subunit 10 OS=Homo sapiens OX=9606 GN=TAF10 PE=1 SV=1" "0.000" "False" "12.443" "15" "2" "3" "2" "218" "21.7" "6.57" "11.86" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03540" "6881" "ENSG00000166337" "TAF10" "hsa:6881; O00703; Q12962; Q13175; Q6FH13" "" "HATs acetylate histones; Ub-specific processing proteases; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation" "11" "0" "1.049" "1.189" "1.339" "0.949" "1.143" "1.173" "1.343" "0.959" "0.774" "42.1" "44.2" "50.1" "56.4" "40.0" "48.2" "49.4" "56.6" "40.4" "32.6" "" "" "" "" "" "" "" "" "" "" "22.3" "24.5" "28.7" "26.0" "21.6" "26.8" "29.1" "30.9" "22.7" "32.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "968979890096343817" "False" "High" "IsMasterProtein" "P53611" "Geranylgeranyl transferase type-2 subunit beta OS=Homo sapiens OX=9606 GN=RABGGTB PE=1 SV=2" "0.000" "False" "12.433" "8" "3" "5" "3" "331" "36.9" "5.03" "12.15" "3" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00432" "5876" "ENSG00000137955" "RABGGTB" "hsa:5876; P53611; Q92697" "" "RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "2" "0" "0.998" "0.975" "1.101" "0.956" "1.049" "0.978" "1.005" "0.878" "0.935" "255.9" "255.3" "249.6" "281.6" "244.6" "268.5" "250.2" "257.1" "224.6" "239.2" "" "" "" "" "" "" "" "" "" "" "135.5" "141.6" "142.9" "129.7" "132.3" "149.4" "147.2" "140.3" "126.0" "239.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-253239951813173210" "False" "High" "IsMasterProtein" "Q9H2M9" "Rab3 GTPase-activating protein non-catalytic subunit OS=Homo sapiens OX=9606 GN=RAB3GAP2 PE=1 SV=1" "0.000" "False" "12.421" "3" "4" "4" "4" "1393" "155.9" "5.62" "11.84" "4" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf14655, Pf14656" "25782" "ENSG00000118873" "RAB3GAP2" "A6H8V0; hsa:25782; O75872; Q9H2M9; Q9HAB0; Q9UFJ7; Q9UQ15" "" "RAB GEFs exchange GTP for GDP on RABs; COPI-independent Golgi-to-ER retrograde traffic" "2" "0" "1.328" "1.120" "1.485" "1.118" "0.934" "1.180" "0.699" "1.166" "6.945" "53.0" "70.3" "59.3" "78.6" "59.2" "49.5" "62.5" "37.1" "61.8" "367.9" "" "" "" "" "" "" "" "" "" "" "28.1" "39.0" "34.0" "36.2" "32.0" "27.5" "36.8" "20.2" "34.7" "367.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8219779968186532826" "False" "High" "IsMasterProtein" "Q9UI26" "Importin-11 OS=Homo sapiens OX=9606 GN=IPO11 PE=1 SV=1" "0.000" "False" "12.421" "4" "3" "4" "3" "975" "112.5" "5.25" "8.35" "3" "transport" "cytosol;nucleus" "other molecular function" "Pf03810" "51194" "ENSG00000086200" "IPO11" "A6NGJ5; B4DZ73; D3DW98; hsa:51194; Q8N5R2; Q9NSJ6; Q9NVB1; Q9UI26" "" "" "0" "0" "1.024" "1.008" "1.065" "1.023" "1.034" "1.012" "0.983" "0.985" "0.931" "512.2" "524.3" "516.4" "545.7" "524.1" "529.5" "518.3" "503.3" "504.6" "476.8" "" "" "" "" "" "" "" "" "" "" "271.2" "290.7" "295.7" "251.3" "283.5" "294.5" "305.1" "274.7" "283.1" "476.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1984767701943514611" "False" "High" "IsMasterProtein" "Q9NQS1" "Cell death regulator Aven OS=Homo sapiens OX=9606 GN=AVEN PE=1 SV=1" "0.000" "False" "12.404" "14" "5" "5" "5" "362" "38.5" "4.98" "13.21" "5" "other biological processes" "other membranes;cytosol;other cell component" "" "" "57099" "ENSG00000169857" "AVEN" "hsa:57099; Q9NQS1" "" "Regulation of the apoptosome activity" "2" "0" "1.136" "1.249" "1.106" "1.077" "1.094" "1.136" "1.140" "1.163" "0.689" "430.1" "488.6" "537.3" "475.7" "463.0" "470.4" "488.6" "490.5" "500.1" "296.1" "" "" "" "" "" "" "" "" "" "" "227.7" "270.9" "307.7" "219.1" "250.5" "261.7" "287.6" "267.7" "280.5" "296.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7717168989126712836" "False" "High" "IsMasterProtein" "Q8TAF3" "WD repeat-containing protein 48 OS=Homo sapiens OX=9606 GN=WDR48 PE=1 SV=1" "0.000" "False" "12.399" "5" "4" "5" "4" "677" "76.2" "7.03" "13.28" "4" "DNA metabolism;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00400, Pf11816" "57599" "ENSG00000114742" "WDR48" "B4DM86; B4DQI2; B4DY84; hsa:57599; Q63HJ2; Q658Y1; Q8N3Z1; Q8TAF3; Q9NSK8; Q9P279" "DNA repair pathways, full network" "Ub-specific processing proteases; Fanconi Anemia Pathway; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins; Recognition of DNA damage by PCNA-containing replication complex" "5" "0" "0.993" "1.016" "1.096" "1.088" "1.004" "0.899" "1.029" "1.046" "0.749" "545.8" "542.1" "554.5" "598.5" "594.1" "548.2" "490.7" "561.8" "570.8" "409.0" "" "" "" "" "" "" "" "" "" "" "289.0" "300.5" "317.6" "275.6" "321.4" "304.9" "288.8" "306.7" "320.2" "409.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5375173174660804131" "False" "High" "IsMasterProtein" "Q16698" "2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial OS=Homo sapiens OX=9606 GN=DECR1 PE=1 SV=1" "0.000" "False" "12.388" "9" "3" "6" "3" "335" "36.0" "9.28" "12.63" "3" "other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf13561" "1666" "ENSG00000104325" "DECR1" "B7Z6B8; hsa:1666; Q16698; Q2M304; Q93085" "Fatty acid beta-oxidation; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling; Omega-6-fatty acids in senescence" "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" "5" "0" "1.219" "1.139" "1.246" "1.202" "1.006" "1.340" "1.174" "1.205" "0.645" "163.2" "198.8" "185.8" "203.3" "196.2" "164.2" "218.6" "191.6" "196.6" "105.2" "" "" "" "" "" "" "" "" "" "" "86.4" "110.2" "106.4" "93.6" "106.1" "91.3" "128.6" "104.6" "110.3" "105.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4549741875275556482" "False" "High" "IsMasterProtein" "Q99627" "COP9 signalosome complex subunit 8 OS=Homo sapiens OX=9606 GN=COPS8 PE=1 SV=1" "0.000" "False" "12.379" "7" "1" "4" "1" "209" "23.2" "5.38" "14.39" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf10075" "10920" "ENSG00000198612" "COPS8" "A8K1H6; hsa:10920; Q53QS9; Q99627" "Ciliary landscape; 2q37 copy number variation syndrome" "DNA Damage Recognition in GG-NER; Cargo recognition for clathrin-mediated endocytosis; Neddylation; Formation of TC-NER Pre-Incision Complex" "6" "0" "1.088" "0.850" "1.367" "1.411" "1.087" "1.207" "1.012" "0.993" "0.925" "36.9" "40.2" "31.4" "50.5" "52.1" "40.1" "44.6" "37.4" "36.7" "34.2" "" "" "" "" "" "" "" "" "" "" "19.6" "22.3" "18.0" "23.3" "28.2" "22.3" "26.2" "20.4" "20.6" "34.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6469801124856573436" "False" "High" "IsMasterProtein" "P36404" "ADP-ribosylation factor-like protein 2 OS=Homo sapiens OX=9606 GN=ARL2 PE=1 SV=4" "0.000" "False" "12.377" "11" "2" "4" "2" "184" "20.9" "6.34" "12.95" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00025" "402" "ENSG00000213465" "ARL2" "G3V184; hsa:402; P36404; Q9BUK8" "Joubert syndrome" "Post-chaperonin tubulin folding pathway; Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; RAS processing" "4" "0" "0.961" "0.774" "1.040" "0.719" "0.912" "1.027" "0.863" "0.809" "0.578" "68.3" "65.7" "52.9" "71.1" "49.2" "62.3" "70.2" "59.0" "55.3" "39.5" "" "" "" "" "" "" "" "" "" "" "36.2" "36.4" "30.3" "32.7" "26.6" "34.7" "41.3" "32.2" "31.0" "39.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5631999146533429965" "False" "High" "IsMasterProtein" "Q02878" "Large ribosomal subunit protein eL6 OS=Homo sapiens OX=9606 GN=RPL6 PE=1 SV=3" "0.000" "False" "12.375" "12" "4" "4" "4" "288" "32.7" "10.58" "12.21" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01159, Pf03868" "6128" "ENSG00000089009" "RPL6" "hsa:6128; Q02878; Q2M3Q3; Q8WW97" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.958" "1.004" "1.173" "0.949" "1.084" "0.877" "0.841" "0.914" "0.943" "434.9" "416.5" "436.6" "510.0" "412.6" "471.3" "381.5" "365.6" "397.5" "410.2" "" "" "" "" "" "" "" "" "" "" "230.3" "230.9" "250.1" "234.9" "223.2" "262.2" "224.5" "199.6" "223.0" "410.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3819373703684901703" "False" "High" "IsMasterProtein" "Q2KHT3" "Protein CLEC16A OS=Homo sapiens OX=9606 GN=CLEC16A PE=1 SV=2" "0.000" "False" "12.371" "3" "4" "4" "4" "1053" "117.6" "5.86" "12.24" "4" "other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf09758, Pf19439" "23274" "ENSG00000038532" "CLEC16A" "hsa:23274; O15058; Q2KHT3; Q6ZTB2" "Vitamin D receptor pathway" "" "1" "0" "1.046" "1.019" "1.058" "1.100" "1.044" "1.055" "1.007" "1.003" "0.598" "610.1" "638.4" "621.7" "645.6" "671.1" "636.8" "643.8" "614.6" "612.0" "364.9" "" "" "" "" "" "" "" "" "" "" "323.0" "353.9" "356.1" "297.3" "363.1" "354.2" "378.9" "335.5" "343.3" "364.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4801012359298608333" "False" "High" "IsMasterProtein" "Q6L8Q7" "2',5'-phosphodiesterase 12 OS=Homo sapiens OX=9606 GN=PDE12 PE=1 SV=2" "0.000" "False" "12.368" "6" "4" "5" "4" "609" "67.3" "6.57" "14.12" "4" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf03372, Pf21171" "201626" "ENSG00000174840" "PDE12" "B4DTU8; hsa:201626; Q6L8Q7; Q8IYU3; Q8NDU2; Q8TE78" "Phosphodiesterases in neuronal function" "OAS antiviral response" "2" "0" "0.997" "0.983" "0.985" "1.009" "0.997" "0.958" "0.915" "0.858" "0.948" "678.7" "676.9" "667.3" "668.5" "684.6" "676.9" "650.3" "621.1" "582.0" "643.2" "" "" "" "" "" "" "" "" "" "" "359.4" "375.3" "382.2" "307.9" "370.4" "376.5" "382.7" "339.0" "326.5" "643.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3468928122779261644" "False" "High" "IsMasterProtein" "P51398" "Small ribosomal subunit protein mS29 OS=Homo sapiens OX=9606 GN=DAP3 PE=1 SV=1" "0.000" "False" "12.354" "9" "3" "4" "3" "398" "45.5" "8.88" "10.38" "3" "protein metabolism;other metabolic processes;signal transduction" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf10236" "7818" "ENSG00000132676" "DAP3" "B4DP59; B4DY62; E7EM60; hsa:7818; P51398; Q13044; Q68CT7; Q96Q20" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.922" "0.930" "1.033" "1.063" "0.955" "0.831" "0.698" "0.846" "1.925" "164.9" "152.0" "153.3" "170.3" "175.2" "157.5" "137.0" "115.1" "139.5" "317.3" "" "" "" "" "" "" "" "" "" "" "87.3" "84.3" "87.8" "78.4" "94.8" "87.6" "80.6" "62.8" "78.2" "317.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "274876564336853802" "False" "High" "IsMasterProtein" "Q01804" "OTU domain-containing protein 4 OS=Homo sapiens OX=9606 GN=OTUD4 PE=1 SV=4" "0.000" "False" "12.346" "4" "4" "5" "4" "1114" "124.0" "6.71" "10.98" "4" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02338" "54726" "ENSG00000164164" "OTUD4" "B4DYS4; hsa:54726; Q01804; Q147U2; Q1ZYK1; Q6PG39; Q96MQ5; Q9NT94; Q9UPV6" "" "" "0" "0" "0.989" "0.943" "0.973" "0.925" "1.040" "0.923" "0.983" "0.934" "0.999" "185.0" "183.0" "174.4" "180.1" "171.1" "192.4" "170.8" "181.8" "172.9" "184.9" "" "" "" "" "" "" "" "" "" "" "98.0" "101.5" "99.9" "82.9" "92.5" "107.0" "100.5" "99.2" "97.0" "184.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1773607396615155691" "False" "High" "IsMasterProtein" "Q16774" "Guanylate kinase OS=Homo sapiens OX=9606 GN=GUK1 PE=1 SV=2" "0.000" "False" "12.342" "13" "3" "5" "3" "197" "21.7" "6.55" "11.56" "3" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00625" "2987" "ENSG00000143774" "GUK1" "B1ANH1; hsa:2987; Q16774" "" "Interconversion of nucleotide di- and triphosphates; Azathioprine ADME" "2" "0" "1.153" "1.304" "1.228" "1.660" "1.390" "0.990" "0.073" "1.013" "9.395" "42.9" "49.5" "56.0" "52.7" "71.3" "59.7" "42.5" "3.1" "43.5" "403.5" "" "" "" "" "" "" "" "" "" "" "22.7" "27.4" "32.1" "24.3" "38.6" "33.2" "25.0" "1.7" "24.4" "403.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4854644692515831998" "False" "High" "IsMasterProtein" "Q86X76" "Deaminated glutathione amidase OS=Homo sapiens OX=9606 GN=NIT1 PE=1 SV=2" "0.000" "False" "12.334" "9" "3" "3" "3" "327" "35.9" "7.74" "9.57" "3" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00795" "4817" "ENSG00000158793" "NIT1" "B1AQP3; D3DVF4; hsa:4817; O76091; Q86X76" "" "" "0" "0" "1.775" "0.981" "1.631" "1.192" "1.333" "1.156" "1.047" "1.251" "0.685" "174.5" "309.7" "171.1" "284.5" "207.9" "232.5" "201.8" "182.7" "218.3" "119.5" "" "" "" "" "" "" "" "" "" "" "92.4" "171.7" "98.0" "131.0" "112.5" "129.3" "118.7" "99.7" "122.5" "119.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "141064915599705120" "False" "High" "IsMasterProtein" "Q9P000" "COMM domain-containing protein 9 OS=Homo sapiens OX=9606 GN=COMMD9 PE=1 SV=2" "0.000" "False" "12.317" "17" "3" "3" "3" "198" "21.8" "5.88" "9.00" "3" "transport;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf07258, Pf20923" "29099" "ENSG00000110442" "COMMD9" "E9PAN2; hsa:29099; Q96FI2; Q9H0R0; Q9P000" "" "Neutrophil degranulation; Neddylation" "2" "0" "0.980" "1.128" "0.948" "1.032" "1.293" "1.090" "1.107" "1.182" "1.404" "261.7" "256.4" "295.2" "248.2" "270.0" "338.4" "285.3" "289.7" "309.3" "367.4" "" "" "" "" "" "" "" "" "" "" "138.6" "142.2" "169.1" "114.3" "146.1" "188.2" "167.9" "158.2" "173.5" "367.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6246281522193444266" "False" "High" "IsMasterProtein" "O60573" "Eukaryotic translation initiation factor 4E type 2 OS=Homo sapiens OX=9606 GN=EIF4E2 PE=1 SV=1" "0.000" "False" "12.310" "14" "3" "3" "3" "245" "28.3" "8.88" "5.98" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01652" "9470" "ENSG00000135930" "EIF4E2" "B8ZZJ9; hsa:9470; O60573; O75349" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; EGFR tyrosine kinase inhibitor resistance" "ISG15 antiviral mechanism" "4" "0" "0.775" "1.074" "1.079" "1.061" "1.367" "1.387" "1.616" "1.491" "1.832" "42.7" "33.1" "45.9" "46.1" "45.4" "58.4" "59.3" "69.1" "63.7" "78.3" "" "" "" "" "" "" "" "" "" "" "22.6" "18.4" "26.3" "21.2" "24.5" "32.5" "34.9" "37.7" "35.8" "78.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2253036871243965201" "False" "High" "IsMasterProtein" "Q15014" "Mortality factor 4-like protein 2 OS=Homo sapiens OX=9606 GN=MORF4L2 PE=1 SV=1" "0.000" "False" "12.301" "10" "3" "3" "2" "288" "32.3" "9.72" "10.53" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "" "Pf05712" "9643" "ENSG00000123562" "MORF4L2" "B3KP92; D3DXA5; hsa:9643; Q15014; Q567V0; Q8J026" "" "HATs acetylate histones" "1" "1" "1.028" "1.094" "1.006" "0.951" "1.022" "0.985" "1.086" "1.018" "1.111" "354.0" "364.0" "387.2" "356.1" "336.7" "361.9" "348.8" "384.5" "360.3" "393.2" "" "" "" "" "" "" "" "" "" "" "187.4" "201.8" "221.8" "164.0" "182.1" "201.3" "205.3" "209.9" "202.1" "393.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5646887584104105884" "False" "High" "IsMasterProtein" "Q9BW61" "DET1- and DDB1-associated protein 1 OS=Homo sapiens OX=9606 GN=DDA1 PE=1 SV=1" "0.000" "False" "12.281" "37" "3" "4" "3" "102" "11.8" "8.68" "11.17" "3" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf10172" "79016" "ENSG00000130311" "DDA1" "hsa:79016; Q9BW61" "" "Neddylation" "1" "0" "0.959" "1.136" "0.917" "1.096" "0.899" "0.926" "1.021" "0.931" "0.996" "81.1" "77.8" "92.1" "74.3" "88.9" "72.9" "75.0" "82.8" "75.4" "80.7" "" "" "" "" "" "" "" "" "" "" "42.9" "43.1" "52.8" "34.2" "48.1" "40.5" "44.2" "45.2" "42.3" "80.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7785444937320200778" "False" "High" "IsMasterProtein" "P17544" "Cyclic AMP-dependent transcription factor ATF-7 OS=Homo sapiens OX=9606 GN=ATF7 PE=1 SV=3" "0.000" "False" "12.279" "8" "5" "6" "3" "483" "51.7" "8.00" "10.75" "5" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "11016" "ENSG00000170653" "ATF7" "A5D6Y4; B2RMP1; B4DQL4; hsa:11016; P17544; Q13814; Q8IVR8; Q9UD83" "" "" "0" "2" "1.058" "1.084" "1.086" "1.010" "1.000" "0.979" "1.144" "1.053" "0.776" "617.4" "653.5" "669.0" "670.2" "623.6" "617.1" "604.7" "706.3" "650.1" "479.0" "" "" "" "" "" "" "" "" "" "" "326.9" "362.3" "383.2" "308.7" "337.4" "343.3" "355.9" "385.6" "364.7" "479.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3635452200201599036" "False" "High" "IsMasterProtein" "Q12904" "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Homo sapiens OX=9606 GN=AIMP1 PE=1 SV=2" "0.000" "False" "12.248" "12" "4" "5" "4" "312" "34.3" "8.43" "9.92" "4" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf01588" "9255" "ENSG00000164022" "AIMP1" "B3KTR2; B4E1S7; hsa:9255; Q12904; Q6FG28; Q96CQ9" "Ciliary landscape" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "3" "0" "1.080" "1.062" "1.203" "1.014" "1.070" "1.013" "0.803" "0.996" "2.639" "268.5" "290.1" "285.2" "323.1" "272.4" "287.4" "272.0" "215.5" "267.5" "708.7" "" "" "" "" "" "" "" "" "" "" "142.2" "160.8" "163.3" "148.8" "147.4" "159.9" "160.1" "117.6" "150.1" "708.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6508547570803101910" "False" "High" "IsMasterProtein" "Q00169" "Phosphatidylinositol transfer protein alpha isoform OS=Homo sapiens OX=9606 GN=PITPNA PE=1 SV=2" "0.000" "False" "12.227" "17" "5" "8" "4" "270" "31.8" "6.55" "16.04" "5" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "transporter activity;other molecular function" "Pf02121" "5306" "ENSG00000174238" "PITPNA" "hsa:5306; Q00169" "" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Role of second messengers in netrin-1 signaling" "2" "0" "0.988" "0.888" "0.945" "0.822" "0.822" "0.889" "0.958" "0.825" "0.436" "273.7" "270.4" "243.0" "258.7" "225.0" "225.1" "243.2" "262.3" "225.9" "119.2" "" "" "" "" "" "" "" "" "" "" "144.9" "149.9" "139.2" "119.1" "121.8" "125.2" "143.2" "143.2" "126.7" "119.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8250154090209623680" "False" "High" "IsMasterProtein" "Q9H2W6" "Large ribosomal subunit protein mL46 OS=Homo sapiens OX=9606 GN=MRPL46 PE=1 SV=1" "0.000" "False" "12.216" "13" "4" "5" "4" "279" "31.7" "7.05" "13.84" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "other molecular function" "Pf11788" "26589" "ENSG00000259494" "MRPL46" "B2RD75; hsa:26589; Q9H2W6; Q9HBU8" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.024" "1.145" "1.085" "1.215" "1.124" "1.022" "0.890" "1.049" "1.048" "392.5" "401.8" "449.3" "425.9" "476.8" "441.0" "401.1" "349.4" "411.7" "411.4" "" "" "" "" "" "" "" "" "" "" "207.8" "222.8" "257.3" "196.1" "258.0" "245.3" "236.0" "190.7" "230.9" "411.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4265990204774033592" "False" "High" "IsMasterProtein" "O75175" "CCR4-NOT transcription complex subunit 3 OS=Homo sapiens OX=9606 GN=CNOT3 PE=1 SV=1" "0.000" "False" "12.211" "5" "4" "4" "4" "753" "81.8" "6.20" "10.50" "4" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04065, Pf04153" "4849" "ENSG00000088038; ENSG00000273943; ENSG00000274176; ENSG00000274616; ENSG00000274941; ENSG00000275979; ENSG00000276082; ENSG00000277114; ENSG00000277600; ENSG00000277615" "CNOT3" "hsa:4849; O75175; Q9NZN7; Q9UF76" "" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "3" "0" "1.073" "1.034" "1.089" "1.106" "1.091" "1.491" "1.561" "1.500" "1.863" "303.8" "326.2" "314.2" "330.9" "336.0" "331.6" "452.9" "474.1" "455.6" "565.9" "" "" "" "" "" "" "" "" "" "" "160.9" "180.8" "179.9" "152.4" "181.8" "184.4" "266.5" "258.8" "255.6" "565.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3441790046039018783" "False" "High" "IsMasterProtein" "Q9UQN3" "Charged multivesicular body protein 2b OS=Homo sapiens OX=9606 GN=CHMP2B PE=1 SV=1" "0.000" "False" "12.184" "19" "5" "6" "5" "213" "23.9" "8.76" "18.22" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "25978" "ENSG00000083937" "CHMP2B" "B4DJG8; hsa:25978; Q53HC7; Q9UQN3; Q9Y4U6" "" "Pyroptosis; Macroautophagy; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III; Late endosomal microautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "9" "0" "0.943" "1.051" "1.093" "0.942" "0.975" "0.944" "1.046" "0.943" "0.668" "519.8" "490.3" "546.2" "568.1" "489.7" "507.0" "490.9" "543.7" "490.3" "347.3" "" "" "" "" "" "" "" "" "" "" "275.2" "271.8" "312.8" "261.6" "265.0" "282.0" "288.9" "296.8" "275.0" "347.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3895404278384693276" "False" "High" "IsMasterProtein" "P08047" "Transcription factor Sp1 OS=Homo sapiens OX=9606 GN=SP1 PE=1 SV=3" "0.000" "False" "12.166" "4" "1" "1" "1" "785" "80.6" "7.34" "5.83" "1" "stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "6667" "ENSG00000185591" "SP1" "E4Z9M7; G5E9M8; hsa:6667; P08047; Q86TN8; Q9H3Q5; Q9NR51; Q9NY21; Q9NYE7" "Androgen receptor signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; IL-17 signaling pathway; Androgen receptor network in prostate cancer; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Constitutive androstane receptor pathway; Estrogen receptor pathway; Nuclear receptors meta-pathway; Myometrial relaxation and contraction pathways; Copper homeostasis; Initiation of transcription and translation elongation at the HIV-1 LTR; MECP2 and associated Rett syndrome; TGF-beta signaling pathway; Mitochondrial gene expression; Oxidative stress response; Breast cancer pathway; Ethanol metabolism production of ROS by CYP2E1; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Gastrin signaling pathway; IL-18 signaling pathway; Angiotensin II receptor type 1 pathway; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; Genetic causes of porto-sinusoidal vascular disease; HDAC6 interactions in the central nervous system; Pathways in cancer; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway" "PPARA activates gene expression; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Oncogene Induced Senescence; Activation of gene expression by SREBF (SREBP); SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Regulation of CDH11 gene transcription; NFE2L2 regulating tumorigenic genes" "42" "0" "0.987" "0.982" "0.791" "0.932" "1.084" "0.857" "0.958" "1.069" "0.705" "100.3" "99.0" "98.5" "79.4" "93.5" "108.7" "86.0" "96.1" "107.3" "70.7" "" "" "" "" "" "" "" "" "" "" "53.1" "54.9" "56.4" "36.5" "50.6" "60.5" "50.6" "52.5" "60.2" "70.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174641781052764353" "False" "High" "IsMasterProtein" "Q9P2T1" "GMP reductase 2 OS=Homo sapiens OX=9606 GN=GMPR2 PE=1 SV=1" "0.000" "False" "12.159" "12" "4" "4" "4" "348" "37.9" "7.23" "10.70" "4" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00478" "51292" "ENSG00000100938; ENSG00000284752" "GMPR2" "D3DS66; hsa:51292; Q567T0; Q6IAJ8; Q86T14; Q9P2T1" "" "Purine salvage" "1" "0" "0.944" "0.916" "0.943" "1.010" "0.995" "1.032" "0.956" "0.972" "0.573" "532.3" "502.3" "487.4" "501.9" "537.4" "529.6" "549.4" "509.0" "517.4" "304.9" "" "" "" "" "" "" "" "" "" "" "281.8" "278.5" "279.1" "231.1" "290.7" "294.6" "323.3" "277.9" "290.3" "304.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3256219212228257535" "False" "High" "IsMasterProtein" "P15104" "Glutamine synthetase OS=Homo sapiens OX=9606 GN=GLUL PE=1 SV=4" "0.000" "False" "12.131" "10" "4" "7" "4" "373" "42.0" "6.89" "19.96" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00120, Pf03951" "2752" "ENSG00000135821" "GLUL" "hsa:2752; P15104; Q499Y9; Q5T9Z1; Q7Z3W4; Q8IZ17" "TNF-alpha signaling pathway; Amino acid metabolism; Cell lineage map for neuronal differentiation" "Glutamate and glutamine metabolism; Astrocytic Glutamate-Glutamine Uptake And Metabolism" "5" "0" "1.012" "1.085" "0.998" "0.967" "0.949" "0.981" "0.926" "1.048" "0.603" "361.4" "365.9" "392.1" "360.7" "349.5" "343.1" "354.5" "334.8" "378.6" "218.1" "" "" "" "" "" "" "" "" "" "" "191.4" "202.8" "224.5" "166.1" "189.1" "190.8" "208.6" "182.8" "212.4" "218.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5219195248541824635" "False" "High" "IsMasterProtein" "Q92609" "TBC1 domain family member 5 OS=Homo sapiens OX=9606 GN=TBC1D5 PE=1 SV=1" "0.000" "False" "12.127" "5" "3" "3" "3" "795" "88.9" "6.54" "8.80" "3" "other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00566" "9779" "ENSG00000131374" "TBC1D5" "A6NP25; C9JP52; hsa:9779; Q92609" "" "" "0" "0" "1.112" "1.091" "1.145" "1.137" "1.257" "1.355" "1.108" "1.353" "3.704" "120.0" "133.5" "130.9" "137.4" "136.5" "150.9" "162.6" "133.0" "162.3" "444.5" "" "" "" "" "" "" "" "" "" "" "63.5" "74.0" "75.0" "63.3" "73.9" "83.9" "95.7" "72.6" "91.1" "444.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "765579875042607640" "False" "High" "IsMasterProtein" "Q15843" "NEDD8 OS=Homo sapiens OX=9606 GN=NEDD8 PE=1 SV=1" "0.000" "False" "12.102" "25" "2" "9" "2" "81" "9.1" "8.43" "21.69" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00240" "4738" "ENSG00000129559; ENSG00000285246" "NEDD8" "hsa:4738; Q15843; Q3SXN8; Q6LES6" "EGF/EGFR signaling pathway; 2q37 copy number variation syndrome" "UCH proteinases; Neddylation; Cargo recognition for clathrin-mediated endocytosis; Iron uptake and transport; TGF-beta receptor signaling activates SMADs" "7" "0" "1.056" "1.122" "1.034" "1.079" "0.976" "1.094" "0.890" "0.952" "0.739" "293.8" "310.2" "329.6" "303.9" "317.0" "286.7" "321.4" "261.4" "279.7" "217.3" "" "" "" "" "" "" "" "" "" "" "155.6" "172.0" "188.7" "140.0" "171.5" "159.5" "189.2" "142.7" "156.9" "217.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9028825818345530826" "False" "High" "IsMasterProtein" "Q9UNZ5" "Leydig cell tumor 10 kDa protein homolog OS=Homo sapiens OX=9606 GN=C19orf53 PE=1 SV=1" "0.000" "False" "12.098" "32" "4" "6" "4" "99" "10.6" "11.55" "19.39" "4" "" "" "" "Pf09495" "28974" "ENSG00000104979" "C19orf53" "B2R4J9; hsa:28974; Q9UNZ5" "" "" "0" "0" "1.034" "1.074" "1.186" "0.842" "0.893" "0.846" "1.195" "1.014" "0.495" "902.7" "933.2" "969.1" "1070.4" "760.1" "805.9" "763.7" "1079.1" "915.6" "446.8" "" "" "" "" "" "" "" "" "" "" "478.0" "517.4" "555.0" "492.9" "411.2" "448.3" "449.5" "589.0" "513.6" "446.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2491360545906137157" "False" "High" "IsMasterProtein" "P54920" "Alpha-soluble NSF attachment protein OS=Homo sapiens OX=9606 GN=NAPA PE=1 SV=3" "0.000" "False" "12.092" "10" "3" "3" "3" "295" "33.2" "5.36" "9.61" "3" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf14938" "8775" "ENSG00000105402" "NAPA" "A8K879; hsa:8775; P54920; Q96IK3; Q9BVJ3" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling" "Golgi Associated Vesicle Biogenesis; Retrograde transport at the Trans-Golgi-Network; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport" "8" "0" "0.926" "1.092" "1.112" "1.050" "1.154" "1.219" "1.213" "1.179" "1.208" "383.9" "355.6" "419.3" "427.1" "403.3" "443.0" "468.0" "465.8" "452.8" "463.7" "" "" "" "" "" "" "" "" "" "" "203.3" "197.1" "240.1" "196.7" "218.2" "246.4" "275.4" "254.3" "254.0" "463.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7438852567896609676" "False" "High" "IsMasterProtein" "Q7L5N1" "COP9 signalosome complex subunit 6 OS=Homo sapiens OX=9606 GN=COPS6 PE=1 SV=1" "0.000" "False" "12.080" "11" "4" "8" "4" "327" "36.1" "5.73" "25.27" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01398, Pf13012" "10980" "ENSG00000168090" "COPS6" "A4D2A3; hsa:10980; O15387; Q7L5N1" "Nucleotide-binding oligomerization domain (NOD) pathway; Ciliary landscape" "Neddylation; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER" "6" "0" "0.840" "0.833" "0.758" "0.785" "0.845" "0.980" "0.849" "0.737" "0.567" "780.3" "655.5" "649.8" "591.7" "612.6" "659.2" "764.9" "662.2" "575.3" "442.2" "" "" "" "" "" "" "" "" "" "" "413.2" "363.4" "372.1" "272.5" "331.5" "366.7" "450.2" "361.4" "322.8" "442.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2292844797767435028" "False" "High" "IsMasterProtein" "Q9H074" "Polyadenylate-binding protein-interacting protein 1 OS=Homo sapiens OX=9606 GN=PAIP1 PE=1 SV=1" "0.000" "False" "12.080" "8" "5" "8" "5" "479" "53.5" "4.81" "15.10" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf02854, Pf07145" "10605" "ENSG00000172239" "PAIP1" "A6NKV8; hsa:10605; O60455; Q96B61; Q9BS63; Q9H074" "Translation factors" "Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "4" "0" "1.010" "0.986" "1.093" "1.088" "1.012" "1.058" "0.906" "1.038" "0.832" "233.7" "236.1" "230.3" "255.5" "254.4" "236.6" "247.2" "211.6" "242.5" "194.4" "" "" "" "" "" "" "" "" "" "" "123.7" "130.9" "131.9" "117.7" "137.6" "131.6" "145.5" "115.5" "136.1" "194.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7262378899326464303" "False" "High" "IsMasterProtein" "Q9BRX5" "DNA replication complex GINS protein PSF3 OS=Homo sapiens OX=9606 GN=GINS3 PE=1 SV=1" "0.000" "False" "12.070" "16" "3" "3" "3" "216" "24.5" "5.34" "9.27" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes" "nucleus" "" "Pf05916" "64785" "ENSG00000181938" "GINS3" "B2RDP3; E9PB21; hsa:64785; Q9BRX5; Q9H870" "" "Unwinding of DNA" "1" "0" "0.944" "0.973" "1.012" "0.848" "0.882" "0.979" "0.954" "0.943" "1.094" "62.4" "58.9" "60.7" "63.2" "52.9" "55.0" "61.1" "59.5" "58.9" "68.3" "" "" "" "" "" "" "" "" "" "" "33.0" "32.7" "34.8" "29.1" "28.6" "30.6" "36.0" "32.5" "33.0" "68.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7708170732071910709" "False" "High" "IsMasterProtein" "O96013" "Serine/threonine-protein kinase PAK 4 OS=Homo sapiens OX=9606 GN=PAK4 PE=1 SV=1" "0.000" "False" "12.069" "5" "3" "6" "3" "591" "64.0" "9.73" "13.47" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00786" "10298" "ENSG00000130669" "PAK4" "B4DGG6; hsa:10298; O96013; Q8N4E1; Q8NCH5; Q8NDE3; Q9BU33; Q9ULS8" "Integrin-mediated cell adhesion; Focal adhesion; MET in type 1 papillary renal cell carcinoma; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 22q11.2 copy number variation syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; TROP2 regulatory signaling; ErbB signaling pathway" "RHOG GTPase cycle; RAC2 GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Activation of RAC1; RHOH GTPase cycle" "25" "0" "1.001" "1.067" "1.042" "1.012" "0.988" "0.949" "0.939" "0.950" "0.844" "289.2" "289.6" "308.6" "301.2" "292.5" "285.7" "274.3" "271.5" "274.6" "244.2" "" "" "" "" "" "" "" "" "" "" "153.1" "160.6" "176.8" "138.7" "158.3" "158.9" "161.4" "148.2" "154.0" "244.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8120903851432865653" "False" "High" "IsMasterProtein" "P01889" "HLA class I histocompatibility antigen, B alpha chain OS=Homo sapiens OX=9606 GN=HLA-B PE=1 SV=3" "0.000" "False" "12.057" "8" "2" "2" "1" "362" "40.4" "5.85" "7.30" "2" "stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00129, Pf06623, Pf07654" "3106" "ENSG00000234745" "HLA-B" "A0A2I6Q7B5; B0V0B8; G3GN01; hsa:3106; O02862; O02956; O02957; O02960; O19555; O19556; O19595; O19615; O19624; O19625; O19627; O19641; O19651; O19675; O19692; O19758; O19779; O19783; O46702; O62897; O62901; O62915; O62917; O62919; O77933; O77959; O78053; O78138; O78160; O78163; O78172; O78173; O78180; O78217; O95730; O98140; P01889; P01890; P03989; P10317; P10318; P10319; P10320; P18463; P18464; P18465; P19373; P30460; P30461; P30462; P30463; P30464; P30465; P30466; P30467; P30468; P30469; P30470; P30471; P30472; P30473; P30474; P30475; P30476; P30477; P30478; P30479; P30480; P30481; P30482; P30483; P30484; P30485; P30486; P30487; P30488; P30489; P30490; P30491; P30492; P30493; P30494; P30495; P30496; P30497; P30498; P30513; P30685; P79489; P79490; P79496; P79504; P79523; P79524; P79542; P79555; Q04826; Q08136; Q29633; Q29636; Q29638; Q29661; Q29665; Q29678; Q29679; Q29681; Q29693; Q29695; Q29697; Q29718; Q29742; Q29749; Q29762; Q29764; Q29829; Q29836; Q29842; Q29845; Q29846; Q29847; Q29848; Q29850; Q29851; Q29852; Q29854; Q29855; Q29857; Q29858; Q29861; Q29924; Q29925; Q29933; Q29935; Q29936; Q29940; Q29953; Q29961; Q29982; Q30173; Q30198; Q31603; Q31610; Q31612; Q31613; Q546L8; Q546M4; Q5JP37; Q5QT24; Q5RIP1; Q5SRJ2; Q5TK76; Q5TK77; Q860I4; Q861B5; Q8HWF0; Q8MGQ3; Q8MHN4; Q8SNC5; Q95343; Q95344; Q95365; Q95369; Q95392; Q95HA3; Q95HA8; Q95HM9; Q95IA6; Q95IB8; Q95IH5; Q95J00; Q96IT9; Q9BCM6; Q9BCM7; Q9BCM8; Q9BD06; Q9BD38; Q9BD43; Q9GIL3; Q9GIM3; Q9GIX1; Q9GIY5; Q9GIZ0; Q9GIZ9; Q9GJ00; Q9GJ17; Q9GJ20; Q9GJ23; Q9GJ31; Q9GJF0; Q9GJM7; Q9MX21; Q9MY37; Q9MY42; Q9MY43; Q9MY61; Q9MY75; Q9MY78; Q9MY79; Q9MY84; Q9MY92; Q9MY93; Q9MY94; Q9MYB8; Q9MYC3; Q9MYC7; Q9MYF4; Q9MYG1; Q9TP35; Q9TP36; Q9TP37; Q9TP95; Q9TPQ7; Q9TPQ9; Q9TPR2; Q9TPR4; Q9TPS6; Q9TPT2; Q9TPT4; Q9TPT6; Q9TPV2; Q9TQG1; Q9TQH3; Q9TQH6; Q9TQH7; Q9TQH8; Q9TQH9; Q9TQM2; Q9TQN4; Q9TQN6; Q9UQS8; Q9UQT0" "Proteasome degradation; Allograft rejection; Ebola virus infection in host; TAR syndrome; Type II interferon signaling" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ER-Phagosome pathway; DAP12 interactions; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Neutrophil degranulation; Interferon gamma signaling; Interferon alpha/beta signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Endosomal/Vacuolar pathway" "14" "0" "1.079" "1.160" "1.158" "1.090" "0.983" "0.879" "1.112" "0.948" "0.475" "149.1" "160.9" "173.0" "172.7" "162.5" "146.6" "131.0" "165.8" "141.3" "70.8" "" "" "" "" "" "" "" "" "" "" "79.0" "89.2" "99.1" "79.5" "87.9" "81.6" "77.1" "90.5" "79.3" "70.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4335544546222164902" "False" "High" "IsMasterProtein" "Q9NRX4" "14 kDa phosphohistidine phosphatase OS=Homo sapiens OX=9606 GN=PHPT1 PE=1 SV=1" "0.000" "False" "12.033" "28" "4" "7" "4" "125" "13.8" "6.07" "17.49" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf05005" "29085" "ENSG00000054148" "PHPT1" "B1AMX0; B1AMX1; hsa:29085; Q9H0Y3; Q9NRX4" "" "" "0" "0" "0.927" "0.966" "0.951" "0.871" "0.821" "0.777" "0.908" "0.891" "0.551" "983.8" "912.3" "950.5" "935.9" "857.2" "807.3" "764.1" "892.8" "877.0" "542.5" "" "" "" "" "" "" "" "" "" "" "520.9" "505.8" "544.4" "431.0" "463.8" "449.1" "449.7" "487.4" "492.0" "542.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7866416472238112790" "False" "High" "IsMasterProtein" "Q14061" "Cytochrome c oxidase copper chaperone OS=Homo sapiens OX=9606 GN=COX17 PE=1 SV=2" "0.000" "False" "12.032" "32" "2" "5" "2" "63" "6.9" "7.24" "16.15" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf05051" "10063" "ENSG00000138495" "COX17" "B2R5D2; D3DN84; hsa:10063; Q14061; Q3MHD6" "Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis; IL-18 signaling pathway; Mitochondrial complex IV assembly" "Mitochondrial protein import" "5" "0" "0.950" "0.960" "0.931" "0.969" "0.886" "0.922" "0.958" "0.921" "0.586" "444.6" "422.3" "427.0" "414.1" "430.8" "394.1" "409.8" "425.9" "409.6" "260.5" "" "" "" "" "" "" "" "" "" "" "235.4" "234.1" "244.5" "190.7" "233.1" "219.2" "241.2" "232.5" "229.8" "260.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8869464350434744721" "False" "High" "IsMasterProtein" "O95372" "Acyl-protein thioesterase 2 OS=Homo sapiens OX=9606 GN=LYPLA2 PE=1 SV=1" "0.000" "False" "12.031" "15" "3" "5" "3" "231" "24.7" "7.23" "7.87" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02230" "11313" "ENSG00000011009" "LYPLA2" "hsa:11313; O95372; Q7Z4Z2" "" "L1CAM interactions" "1" "0" "1.046" "1.043" "1.171" "0.993" "0.983" "1.021" "0.937" "0.924" "0.674" "261.1" "273.1" "272.4" "305.7" "259.2" "256.6" "266.7" "244.7" "241.3" "176.0" "" "" "" "" "" "" "" "" "" "" "138.3" "151.4" "156.0" "140.8" "140.3" "142.7" "157.0" "133.6" "135.4" "176.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2648921608470054018" "False" "High" "IsMasterProtein" "Q96L92" "Sorting nexin-27 OS=Homo sapiens OX=9606 GN=SNX27 PE=1 SV=2" "0.000" "False" "12.018" "5" "3" "3" "3" "541" "61.2" "6.49" "6.87" "3" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00595, Pf00787, Pf00788" "81609" "ENSG00000143376" "SNX27" "hsa:81609; Q32Q36; Q4AEJ5; Q5VWB0; Q5VWB1; Q5VWB2; Q6IPP6; Q86UB1; Q96D79; Q96L92; Q9H3K8" "" "" "0" "0" "1.081" "1.007" "1.141" "1.053" "1.004" "1.109" "0.816" "1.023" "3.874" "336.6" "364.0" "339.1" "384.2" "354.6" "338.0" "373.4" "274.8" "344.5" "1304.1" "" "" "" "" "" "" "" "" "" "" "178.2" "201.8" "194.2" "176.9" "191.9" "188.0" "219.8" "150.0" "193.2" "1304.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6755213045612558311" "False" "High" "IsMasterProtein" "P53367" "Arfaptin-1 OS=Homo sapiens OX=9606 GN=ARFIP1 PE=1 SV=2" "0.000" "False" "12.006" "9" "4" "7" "4" "373" "41.7" "6.70" "16.13" "4" "transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf06456" "27236" "ENSG00000164144" "ARFIP1" "B4DS69; hsa:27236; P53367; Q2M2X4; Q3SYL4; Q9Y2X6" "" "" "0" "0" "1.068" "1.090" "1.157" "0.935" "1.036" "1.052" "1.015" "0.980" "0.703" "195.6" "208.8" "213.1" "226.3" "182.8" "202.6" "205.7" "198.5" "191.7" "137.5" "" "" "" "" "" "" "" "" "" "" "103.5" "115.8" "122.0" "104.2" "98.9" "112.7" "121.1" "108.4" "107.6" "137.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9117117300834082613" "False" "High" "IsMasterProtein" "Q9H5N1" "Rab GTPase-binding effector protein 2 OS=Homo sapiens OX=9606 GN=RABEP2 PE=1 SV=2" "0.000" "False" "12.004" "5" "3" "3" "3" "569" "63.5" "4.78" "8.85" "3" "cell organization and biogenesis;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf03528, Pf09311" "79874" "ENSG00000177548" "RABEP2" "hsa:79874; Q9H5N1" "Ciliary landscape; 16p11.2 distal deletion syndrome" "" "2" "0" "1.244" "1.367" "1.335" "1.234" "1.259" "1.425" "1.451" "1.541" "2.173" "142.5" "177.2" "194.8" "190.2" "175.8" "179.3" "202.9" "206.8" "219.6" "309.6" "" "" "" "" "" "" "" "" "" "" "75.4" "98.2" "111.5" "87.6" "95.1" "99.7" "119.4" "112.9" "123.2" "309.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4306036841848923980" "False" "High" "IsMasterProtein" "Q08752" "Peptidyl-prolyl cis-trans isomerase D OS=Homo sapiens OX=9606 GN=PPID PE=1 SV=3" "0.000" "False" "12.003" "9" "4" "7" "3" "370" "40.7" "7.21" "19.02" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00160" "5481" "ENSG00000171497" "PPID" "B2R9V2; hsa:5481; Q08752" "Alzheimer's disease and miRNA effects; NO/cGMP/PKG mediated neuroprotection; Alzheimer's disease" "ESR-mediated signaling" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3677224009341935597" "False" "High" "IsMasterProtein" "P48729" "Casein kinase I isoform alpha OS=Homo sapiens OX=9606 GN=CSNK1A1 PE=1 SV=2" "0.000" "False" "11.989" "9" "2" "3" "2" "337" "38.9" "9.57" "9.02" "2" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1452" "ENSG00000113712" "CSNK1A1" "D3DQG0; D3DQG1; hsa:1452; P48729; Q4JJA0; Q5U046; Q5U047; Q6FGA2; Q71TU5; Q96HD2; Q9UDK3" "Alzheimer's disease and miRNA effects; T cell receptor and co-stimulatory signaling; Complement system; Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Chromosomal and microsatellite instability in colorectal cancer ; Hedgehog signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Alzheimer's disease; DYRK1A involvement regarding cell proliferation in brain development" "Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Activation of SMO; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Maturation of nucleoprotein" "32" "0" "1.030" "1.072" "1.126" "1.110" "1.241" "1.050" "1.016" "1.036" "1.046" "164.8" "169.6" "176.6" "185.5" "182.9" "204.5" "173.0" "167.5" "170.7" "172.3" "" "" "" "" "" "" "" "" "" "" "87.2" "94.1" "101.1" "85.4" "98.9" "113.8" "101.8" "91.4" "95.8" "172.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2819715853452011200" "False" "High" "IsMasterProtein" "Q8WUD4" "Coiled-coil domain-containing protein 12 OS=Homo sapiens OX=9606 GN=CCDC12 PE=1 SV=1" "0.000" "False" "11.977" "15" "2" "3" "2" "166" "19.2" "7.34" "10.32" "2" "" "nucleus" "" "Pf08315" "151903" "ENSG00000160799" "CCDC12" "hsa:151903; Q8N8I4; Q8WUD4" "" "mRNA Splicing - Major Pathway" "1" "0" "0.994" "0.984" "1.069" "0.900" "0.958" "1.062" "1.210" "1.203" "0.394" "476.8" "473.8" "469.1" "509.5" "429.0" "457.0" "506.3" "576.7" "573.5" "188.0" "" "" "" "" "" "" "" "" "" "" "252.5" "262.7" "268.7" "234.7" "232.1" "254.2" "298.0" "314.8" "321.7" "188.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3124234521907955571" "False" "High" "IsMasterProtein" "Q9NX24" "H/ACA ribonucleoprotein complex subunit 2 OS=Homo sapiens OX=9606 GN=NHP2 PE=1 SV=1" "0.000" "False" "11.960" "18" "2" "3" "2" "153" "17.2" "8.22" "10.69" "2" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf01248" "55651" "ENSG00000145912" "NHP2" "A6NKY8; hsa:55651; Q9NX24; Q9P095" "" "rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase" "2" "0" "1.114" "1.107" "1.118" "1.107" "0.987" "1.060" "1.098" "1.211" "0.805" "534.2" "595.2" "591.3" "597.1" "591.2" "527.3" "566.3" "586.7" "646.9" "430.3" "" "" "" "" "" "" "" "" "" "" "282.9" "330.0" "338.6" "275.0" "319.9" "293.3" "333.3" "320.3" "362.9" "430.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4018200245095699536" "False" "High" "IsMasterProtein" "P55327" "Tumor protein D52 OS=Homo sapiens OX=9606 GN=TPD52 PE=1 SV=2" "0.000" "False" "11.949" "16" "3" "3" "3" "224" "24.3" "4.83" "9.20" "3" "transport;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf04201" "7163" "ENSG00000076554" "TPD52" "B7Z414; C9J502; D0UFD1; D0UFD2; D0UFD3; D0UFD4; D0UFD5; E5RKB4; hsa:7163; P55327; Q13056; Q53EK8; Q6FGP3; Q6FGS3; Q86YZ2; Q9UCX8" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "1.112" "1.151" "1.174" "1.059" "1.090" "1.129" "1.161" "1.131" "0.705" "330.1" "367.2" "379.8" "387.6" "349.7" "359.8" "372.9" "383.4" "373.4" "232.8" "" "" "" "" "" "" "" "" "" "" "174.8" "203.6" "217.5" "178.5" "189.2" "200.1" "219.4" "209.3" "209.5" "232.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "677526654360538548" "False" "High" "IsMasterProtein" "Q99733" "Nucleosome assembly protein 1-like 4 OS=Homo sapiens OX=9606 GN=NAP1L4 PE=1 SV=1" "0.000" "False" "11.946" "9" "4" "13" "3" "375" "42.8" "4.69" "29.30" "4" "cell organization and biogenesis" "nucleus;other cell component" "other molecular function" "Pf00956" "4676" "ENSG00000205531; ENSG00000273562" "NAP1L4" "B2R6J4; F5HFY4; hsa:4676; Q99733" "" "" "0" "1" "1.064" "1.141" "1.203" "0.859" "0.889" "0.860" "1.033" "0.938" "1.077" "964.1" "1025.9" "1099.7" "1160.1" "828.6" "856.7" "829.2" "995.6" "904.1" "1038.3" "" "" "" "" "" "" "" "" "" "" "510.5" "568.8" "629.8" "534.3" "448.3" "476.5" "488.0" "543.5" "507.2" "1038.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1714630333721311506" "False" "High" "IsMasterProtein" "Q6NVY1" "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=HIBCH PE=1 SV=2" "0.000" "False" "11.926" "10" "4" "5" "4" "386" "43.5" "8.19" "11.87" "4" "other metabolic processes" "mitochondrion" "other molecular function" "Pf16113" "26275" "ENSG00000198130" "HIBCH" "D3DPI4; hsa:26275; Q53GA8; Q53GF2; Q53RF7; Q53TC6; Q6NVY1; Q92931; Q9BS94" "Amino acid metabolism" "Branched-chain amino acid catabolism" "2" "0" "1.011" "1.053" "0.996" "1.046" "1.132" "1.042" "0.846" "1.032" "2.243" "842.7" "851.9" "887.5" "839.6" "881.5" "954.3" "878.2" "713.1" "870.0" "1890.4" "" "" "" "" "" "" "" "" "" "" "446.2" "472.3" "508.3" "386.7" "476.9" "530.8" "516.8" "389.2" "488.1" "1890.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8966117974293097362" "False" "High" "IsMasterProtein" "Q9UHL4" "Dipeptidyl peptidase 2 OS=Homo sapiens OX=9606 GN=DPP7 PE=1 SV=3" "0.000" "False" "11.923" "7" "3" "3" "3" "492" "54.3" "6.32" "9.12" "3" "protein metabolism;other metabolic processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05577" "29952" "ENSG00000176978" "DPP7" "A8K7U7; hsa:29952; Q5VSF1; Q969X4; Q9UHL4" "" "Neutrophil degranulation" "1" "0" "1.117" "0.982" "1.080" "1.054" "1.076" "1.153" "1.122" "0.887" "0.550" "173.5" "193.7" "170.3" "187.3" "182.8" "186.7" "199.9" "194.5" "153.8" "95.4" "" "" "" "" "" "" "" "" "" "" "91.8" "107.4" "97.5" "86.3" "98.9" "103.9" "117.7" "106.2" "86.3" "95.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "741210737454912212" "False" "High" "IsMasterProtein" "Q7Z7A4" "PX domain-containing protein kinase-like protein OS=Homo sapiens OX=9606 GN=PXK PE=1 SV=1" "0.000" "False" "11.911" "7" "4" "5" "4" "578" "64.9" "9.35" "13.12" "4" "stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00787, Pf02205" "54899" "ENSG00000168297" "PXK" "hsa:54899; Q3BCH4; Q3BCH5; Q3BCH6; Q3BDW1; Q45L83; Q59EX3; Q6PK17; Q6ZN39; Q7Z7A4; Q96CA3; Q96R07; Q9NXB8" "" "" "0" "0" "1.071" "0.746" "1.289" "1.206" "0.827" "1.055" "0.928" "1.086" "0.990" "32.7" "35.0" "24.4" "42.2" "39.4" "27.0" "34.5" "30.4" "35.5" "32.4" "" "" "" "" "" "" "" "" "" "" "17.3" "19.4" "14.0" "19.4" "21.3" "15.0" "20.3" "16.6" "19.9" "32.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6764282473727919069" "False" "High" "IsMasterProtein" "Q96K17" "Transcription factor BTF3 homolog 4 OS=Homo sapiens OX=9606 GN=BTF3L4 PE=1 SV=1" "0.000" "False" "11.865" "17" "4" "6" "2" "158" "17.3" "6.35" "17.32" "4" "" "" "" "Pf01849" "91408" "ENSG00000134717" "BTF3L4" "B3KNJ1; D3DQ32; G3V1C6; hsa:91408; Q96K17" "" "" "0" "0" "1.088" "1.102" "0.948" "1.029" "1.009" "0.952" "1.168" "1.027" "0.539" "553.5" "602.0" "610.2" "524.4" "569.4" "558.7" "526.9" "646.4" "568.4" "298.1" "" "" "" "" "" "" "" "" "" "" "293.1" "333.8" "349.5" "241.5" "308.1" "310.8" "310.1" "352.8" "318.9" "298.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2198906581928094734" "False" "High" "IsMasterProtein" "Q9BQC3" "2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 OS=Homo sapiens OX=9606 GN=DPH2 PE=1 SV=1" "0.000" "False" "11.846" "9" "4" "4" "4" "489" "52.1" "5.53" "10.66" "4" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01866" "1802" "ENSG00000132768" "DPH2" "A8MVC9; B2RDE3; B4DNI8; hsa:1802; O60623; Q9BQC3" "" "Synthesis of diphthamide-EEF2" "1" "0" "1.008" "1.003" "1.066" "0.959" "1.012" "0.992" "0.864" "0.986" "1.114" "393.2" "396.4" "394.2" "419.2" "377.1" "397.8" "390.1" "339.7" "387.5" "437.8" "" "" "" "" "" "" "" "" "" "" "208.2" "219.8" "225.7" "193.1" "204.0" "221.3" "229.6" "185.4" "217.4" "437.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-65550439794871329" "False" "High" "IsMasterProtein" "Q9BXS5" "AP-1 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP1M1 PE=1 SV=3" "0.000" "False" "11.846" "11" "4" "4" "4" "423" "48.6" "7.30" "9.09" "4" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00928, Pf01217" "8907" "ENSG00000072958" "AP1M1" "hsa:8907; Q4TTY5; Q9BXS5" "" "Neutrophil degranulation; MHC class II antigen presentation; Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "5" "0" "0.838" "0.981" "1.041" "0.980" "1.060" "1.013" "1.073" "1.099" "1.426" "286.6" "240.2" "281.3" "298.4" "280.9" "303.9" "290.3" "307.5" "315.1" "408.8" "" "" "" "" "" "" "" "" "" "" "151.8" "133.2" "161.1" "137.4" "152.0" "169.0" "170.8" "167.8" "176.7" "408.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1347928425928225454" "False" "High" "IsMasterProtein" "O60925" "Prefoldin subunit 1 OS=Homo sapiens OX=9606 GN=PFDN1 PE=1 SV=2" "0.000" "False" "11.844" "21" "3" "5" "3" "122" "14.2" "6.81" "17.68" "3" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf01920" "5201" "ENSG00000113068" "PFDN1" "B2RD02; hsa:5201; O60925; Q53F95; Q96EX6" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "1.040" "1.088" "1.071" "1.033" "1.034" "1.052" "1.104" "1.009" "0.593" "766.6" "796.9" "833.7" "820.9" "791.7" "792.7" "806.5" "846.0" "773.2" "454.3" "" "" "" "" "" "" "" "" "" "" "405.9" "441.8" "477.5" "378.0" "428.3" "440.9" "474.6" "461.8" "433.7" "454.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1282007746480283530" "False" "High" "IsMasterProtein" "Q9BRJ7" "Tudor-interacting repair regulator protein OS=Homo sapiens OX=9606 GN=NUDT16L1 PE=1 SV=1" "0.000" "False" "11.836" "10" "2" "4" "1" "211" "23.3" "8.91" "12.93" "2" "other biological processes" "nucleus" "nucleic acid binding activity" "" "84309" "ENSG00000168101" "NUDT16L1" "Q8NAI2; Q9BRJ7" "" "" "0" "0" "1.097" "1.269" "1.337" "0.964" "1.168" "1.132" "1.069" "0.891" "0.958" "51.4" "56.3" "65.2" "68.7" "49.5" "60.0" "58.1" "54.9" "45.8" "49.2" "" "" "" "" "" "" "" "" "" "" "27.2" "31.2" "37.3" "31.6" "26.8" "33.4" "34.2" "30.0" "25.7" "49.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3647581331953333811" "False" "High" "IsMasterProtein" "Q658Y4" "Protein FAM91A1 OS=Homo sapiens OX=9606 GN=FAM91A1 PE=1 SV=3" "0.000" "False" "11.832" "4" "4" "5" "4" "838" "93.9" "6.39" "13.53" "4" "cell organization and biogenesis;transport" "ER/Golgi;other cell component" "" "Pf14647, Pf14648" "157769" "ENSG00000176853" "FAM91A1" "B6YY23; hsa:157769; Q658T5; Q658Y4; Q8TE89" "Gastric cancer network 2" "RHOH GTPase cycle" "2" "0" "1.015" "0.975" "0.992" "1.065" "1.013" "1.029" "0.976" "0.948" "0.910" "620.4" "629.5" "604.7" "615.6" "660.4" "628.6" "638.2" "605.4" "588.1" "564.6" "" "" "" "" "" "" "" "" "" "" "328.5" "349.0" "346.3" "283.5" "357.3" "349.6" "375.6" "330.5" "329.9" "564.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8826261878749587371" "False" "High" "IsMasterProtein" "P39023" "Large ribosomal subunit protein uL3 OS=Homo sapiens OX=9606 GN=RPL3 PE=1 SV=2" "0.000" "False" "11.830" "11" "5" "6" "5" "403" "46.1" "10.18" "15.95" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00297" "6122" "ENSG00000100316" "RPL3" "B2RDV9; hsa:6122; P39023; Q15548; Q5I0G0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.072" "1.172" "1.223" "1.197" "1.289" "1.111" "0.964" "1.172" "1.912" "695.8" "745.9" "815.6" "851.1" "833.1" "896.7" "772.8" "671.0" "815.2" "1330.3" "" "" "" "" "" "" "" "" "" "" "368.4" "413.6" "467.1" "392.0" "450.7" "498.8" "454.8" "366.3" "457.3" "1330.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4988344905656775202" "False" "High" "IsMasterProtein" "Q92665" "Small ribosomal subunit protein mS31 OS=Homo sapiens OX=9606 GN=MRPS31 PE=1 SV=3" "0.000" "False" "11.827" "10" "4" "4" "4" "395" "45.3" "9.29" "7.68" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf15433" "10240" "ENSG00000102738" "MRPS31" "B2RCS3; hsa:10240; Q5VYC8; Q8WTV8; Q92665" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.984" "0.941" "1.025" "0.997" "0.898" "0.993" "0.829" "0.985" "1.860" "504.3" "496.4" "474.5" "517.2" "502.6" "452.8" "500.9" "418.0" "496.6" "938.1" "" "" "" "" "" "" "" "" "" "" "267.0" "275.2" "271.7" "238.2" "271.9" "251.8" "294.8" "228.2" "278.6" "938.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1985777424174479704" "False" "High" "IsMasterProtein" "Q14669" "E3 ubiquitin-protein ligase TRIP12 OS=Homo sapiens OX=9606 GN=TRIP12 PE=1 SV=1" "0.000" "False" "11.825" "1" "2" "3" "2" "1992" "220.3" "8.48" "10.33" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00632" "9320" "ENSG00000153827" "TRIP12" "D4HL82; Q14669; Q14CA3; Q14CF1; Q15644; Q53R87; Q53TE7" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.170" "1.218" "1.085" "1.329" "1.086" "2.032" "1.481" "1.476" "0.926" "202.9" "237.4" "247.1" "220.2" "269.7" "220.3" "412.4" "300.5" "299.5" "188.0" "" "" "" "" "" "" "" "" "" "" "107.4" "131.6" "141.5" "101.4" "145.9" "122.5" "242.7" "164.0" "168.0" "188.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2272121550069660062" "False" "High" "IsMasterProtein" "P35268" "Large ribosomal subunit protein eL22 OS=Homo sapiens OX=9606 GN=RPL22 PE=1 SV=2" "0.000" "False" "11.820" "19" "2" "2" "2" "128" "14.8" "9.19" "7.72" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01776" "6146" "ENSG00000116251" "RPL22" "B2R495; hsa:6146; P35268; Q6IBD1" "Cytoplasmic ribosomal proteins" "Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.088" "0.946" "1.309" "1.161" "1.306" "1.346" "1.322" "1.339" "1.118" "228.0" "248.1" "215.6" "298.5" "264.7" "297.7" "306.8" "301.4" "305.3" "254.8" "" "" "" "" "" "" "" "" "" "" "120.7" "137.5" "123.5" "137.5" "143.2" "165.6" "180.6" "164.5" "171.3" "254.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5258533483115152097" "False" "High" "IsMasterProtein" "Q53H96" "Pyrroline-5-carboxylate reductase 3 OS=Homo sapiens OX=9606 GN=PYCR3 PE=1 SV=3" "0.000" "False" "11.807" "9" "2" "3" "2" "274" "28.6" "7.72" "3.37" "2" "other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf03807, Pf14748" "65263" "ENSG00000104524; ENSG00000276657" "PYCR3" "B3KMB5; B4DVT6; H0Y6C3; hsa:65263; Q53H96; Q8N3N9; Q96HX4; Q9H896" "" "Glutamate and glutamine metabolism" "1" "0" "1.043" "1.113" "1.093" "1.128" "1.049" "1.118" "1.142" "0.963" "0.777" "144.5" "150.8" "160.9" "158.0" "163.0" "151.5" "161.6" "164.9" "139.2" "112.2" "" "" "" "" "" "" "" "" "" "" "76.5" "83.6" "92.1" "72.8" "88.2" "84.3" "95.1" "90.0" "78.1" "112.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5638474282161267402" "False" "High" "IsMasterProtein" "Q969Z0" "FAST kinase domain-containing protein 4 OS=Homo sapiens OX=9606 GN=TBRG4 PE=1 SV=1" "0.000" "False" "11.805" "5" "4" "4" "4" "631" "70.7" "7.42" "13.23" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "" "Pf06743, Pf08368, Pf08373" "9238" "ENSG00000136270" "TBRG4" "A4D2L2; A4D2L3; D3DVL5; D3DVL6; hsa:9238; O14710; Q53GI8; Q8NDM4; Q969Z0; Q9BUC6; Q9Y2F6" "" "FASTK family proteins regulate processing and stability of mitochondrial RNAs" "1" "0" "0.967" "0.958" "1.127" "0.959" "1.109" "0.957" "0.010" "1.319" "15.128" "151.1" "146.2" "144.8" "170.4" "145.0" "167.6" "144.7" "0.0" "199.4" "2286.3" "" "" "" "" "" "" "" "" "" "" "80.0" "81.1" "82.9" "78.5" "78.4" "93.2" "85.1" "0.0" "111.8" "2286.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2381350149897154971" "False" "High" "IsMasterProtein" "P51572" "B-cell receptor-associated protein 31 OS=Homo sapiens OX=9606 GN=BCAP31 PE=1 SV=3" "0.000" "False" "11.799" "10" "4" "6" "4" "246" "28.0" "8.44" "14.23" "4" "stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05529, Pf18035" "10134" "ENSG00000185825" "BCAP31" "B3KQ79; D3DWV5; hsa:10134; P51572; Q13836; Q96CF0" "" "Antigen Presentation: Folding, assembly and peptide loading of class I MHC; RSV-host interactions; RHOA GTPase cycle; Apoptotic cleavage of cellular proteins" "5" "0" "0.964" "0.973" "1.128" "1.124" "1.039" "2.150" "2.162" "2.093" "0.767" "558.5" "538.6" "543.4" "629.9" "628.0" "580.0" "1200.7" "1207.5" "1169.0" "428.5" "" "" "" "" "" "" "" "" "" "" "295.7" "298.6" "311.2" "290.1" "339.8" "322.6" "706.7" "659.1" "655.8" "428.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-987846664266598251" "False" "High" "IsMasterProtein" "Q9NS87" "Kinesin-like protein KIF15 OS=Homo sapiens OX=9606 GN=KIF15 PE=1 SV=1" "0.000" "False" "11.792" "4" "7" "7" "7" "1388" "160.1" "6.00" "8.41" "7" "cell cycle OR cell proliferation;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf00225, Pf15908" "56992" "ENSG00000163808; ENSG00000280610" "KIF15" "hsa:56992; Q17RV9; Q69YL6; Q96JX7; Q9H280; Q9NS87" "Gastric cancer network 1" "MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "4" "0" "1.036" "0.927" "1.080" "1.109" "1.019" "1.045" "0.709" "1.052" "3.379" "198.5" "205.7" "184.1" "214.5" "220.2" "202.2" "207.4" "140.8" "208.8" "670.8" "" "" "" "" "" "" "" "" "" "" "105.1" "114.0" "105.4" "98.8" "119.1" "112.5" "122.1" "76.9" "117.1" "670.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1789067979643489698" "False" "High" "IsMasterProtein" "P46976" "Glycogenin-1 OS=Homo sapiens OX=9606 GN=GYG1 PE=1 SV=4" "0.000" "False" "11.780" "5" "2" "6" "2" "350" "39.4" "5.53" "11.37" "2" "other metabolic processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01501" "2992" "ENSG00000163754" "GYG1" "D3DNH0; D3DNH1; D3DNH2; hsa:2992; P46976; Q6FHZ1; Q9UNV0" "Insulin signaling; Glycogen synthesis and degradation; Disorders of galactose metabolism" "Neutrophil degranulation; Glycogen synthesis; Glycogen breakdown (glycogenolysis); Myoclonic epilepsy of Lafora; Glycogen storage disease type II (GAA); Glycogen storage disease type XV (GYG1); Glycogen storage disease type 0 (muscle GYS1)" "10" "0" "0.970" "1.008" "1.092" "1.050" "0.992" "1.275" "1.112" "1.076" "0.588" "170.0" "164.9" "171.4" "185.6" "178.5" "168.6" "216.8" "189.0" "182.9" "99.9" "" "" "" "" "" "" "" "" "" "" "90.0" "91.4" "98.1" "85.5" "96.6" "93.8" "127.6" "103.2" "102.6" "99.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2282593962912776213" "False" "High" "IsMasterProtein" "Q15853" "Upstream stimulatory factor 2 OS=Homo sapiens OX=9606 GN=USF2 PE=1 SV=1" "0.000" "False" "11.774" "12" "4" "4" "3" "346" "36.9" "5.10" "10.56" "4" "transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "7392" "ENSG00000105698" "USF2" "hsa:7392; O00671; O00709; Q05750; Q07952; Q15851; Q15852; Q15853; Q6FI33; Q6YI47" "Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4)" "Estrogen-dependent gene expression" "2" "0" "1.078" "1.040" "1.127" "0.998" "1.002" "0.979" "0.950" "0.908" "0.696" "418.6" "451.3" "435.5" "471.6" "417.7" "419.5" "409.6" "397.8" "380.0" "291.3" "" "" "" "" "" "" "" "" "" "" "221.7" "250.2" "249.4" "217.2" "226.0" "233.4" "241.1" "217.1" "213.2" "291.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3211480978683405727" "False" "High" "IsMasterProtein" "O95232" "Luc7-like protein 3 OS=Homo sapiens OX=9606 GN=LUC7L3 PE=1 SV=2" "0.000" "False" "11.770" "9" "5" "5" "5" "432" "51.4" "9.79" "13.32" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf03194" "51747" "ENSG00000108848" "LUC7L3" "B3KN54; D3DTY1; hsa:51747; O95232; Q6PHR9; Q9NUY0; Q9P2S7" "" "mRNA Splicing - Major Pathway" "1" "0" "1.006" "1.078" "1.094" "1.030" "1.015" "1.060" "0.926" "1.136" "1.790" "449.1" "451.7" "484.2" "491.5" "462.5" "455.8" "476.3" "416.0" "510.0" "804.0" "" "" "" "" "" "" "" "" "" "" "237.8" "250.4" "277.3" "226.4" "250.2" "253.6" "280.3" "227.1" "286.1" "804.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1403066018753267541" "False" "High" "IsMasterProtein" "Q96RU3" "Formin-binding protein 1 OS=Homo sapiens OX=9606 GN=FNBP1 PE=1 SV=2" "0.000" "False" "11.764" "4" "3" "5" "3" "617" "71.3" "5.72" "7.26" "3" "transport;signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00611" "23048" "ENSG00000187239" "FNBP1" "B7ZL12; E9PGQ4; hsa:23048; O60301; Q3MIN8; Q5TC87; Q5TC88; Q6P658; Q7LGG2; Q96RU3; Q9H8H8; Q9NWD1" "" "Clathrin-mediated endocytosis; RND2 GTPase cycle; CDC42 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle" "5" "0" "1.124" "1.039" "1.199" "1.070" "1.020" "1.116" "0.684" "1.178" "5.576" "92.3" "103.8" "96.0" "110.7" "98.8" "94.1" "103.1" "63.1" "108.8" "514.7" "" "" "" "" "" "" "" "" "" "" "48.9" "57.5" "55.0" "51.0" "53.4" "52.4" "60.7" "34.5" "61.0" "514.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5181742408378363027" "False" "High" "IsMasterProtein" "P62253" "Ubiquitin-conjugating enzyme E2 G1 OS=Homo sapiens OX=9606 GN=UBE2G1 PE=1 SV=3" "0.000" "False" "11.761" "20" "3" "3" "3" "170" "19.5" "5.30" "9.37" "3" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00179" "7326" "ENSG00000132388" "UBE2G1" "B2R7P2; D3DTK0; hsa:7326; P62253; Q99462" "Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "4" "0" "1.173" "1.226" "1.195" "1.245" "1.262" "1.177" "1.435" "1.228" "0.777" "262.7" "308.1" "322.0" "313.8" "327.0" "331.4" "309.2" "377.1" "322.7" "204.2" "" "" "" "" "" "" "" "" "" "" "139.1" "170.8" "184.4" "144.5" "176.9" "184.4" "182.0" "205.8" "181.0" "204.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5021829867861972309" "False" "High" "IsMasterProtein" "Q14671" "Pumilio homolog 1 OS=Homo sapiens OX=9606 GN=PUM1 PE=1 SV=3" "0.000" "False" "11.757" "4" "4" "4" "2" "1186" "126.4" "6.84" "10.76" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00806" "9698" "ENSG00000134644" "PUM1" "A8K6W4; B4DG92; D3DPN3; E9PCJ0; hsa:9698; Q14671; Q53HH5; Q5VXY7; Q9HAN1" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "0.963" "0.942" "1.104" "1.205" "1.036" "1.208" "1.142" "1.010" "1.597" "99.1" "95.5" "93.4" "109.4" "119.5" "102.7" "119.7" "113.2" "100.1" "158.3" "" "" "" "" "" "" "" "" "" "" "52.5" "53.0" "53.5" "50.4" "64.6" "57.1" "70.5" "61.8" "56.1" "158.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1343964700997120443" "False" "High" "IsMasterProtein" "O94830" "Phospholipase DDHD2 OS=Homo sapiens OX=9606 GN=DDHD2 PE=1 SV=2" "0.000" "False" "11.741" "5" "4" "6" "4" "711" "81.0" "5.39" "14.11" "4" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00536, Pf02825, Pf02862" "23259" "ENSG00000085788" "DDHD2" "B3KWV2; B3KXB5; hsa:23259; O94830; Q9H8X7" "" "Synthesis of PA" "1" "0" "0.987" "0.864" "0.980" "0.974" "1.031" "0.941" "0.890" "0.895" "0.828" "272.0" "268.6" "234.9" "266.6" "265.0" "280.5" "256.1" "242.1" "243.6" "225.2" "" "" "" "" "" "" "" "" "" "" "144.0" "148.9" "134.5" "122.8" "143.4" "156.0" "150.7" "132.1" "136.6" "225.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4669002677123591675" "False" "High" "IsMasterProtein" "P06493" "Cyclin-dependent kinase 1 OS=Homo sapiens OX=9606 GN=CDK1 PE=1 SV=3" "0.000" "False" "11.735" "10" "3" "5" "2" "297" "34.1" "8.40" "13.97" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "983" "ENSG00000170312" "CDK1" "A8K7C4; C9J497; hsa:983; O60764; P06493" "miRNA regulation of DNA damage response; Cell cycle; Microtubule cytoskeleton regulation; Spinal cord injury; Retinoblastoma gene in cancer; ATM signaling pathway; PPAR-alpha pathway; Nuclear receptors meta-pathway; TGF-beta signaling pathway; G1 to S cell cycle control; Cohesin complex - Cornelia de Lange syndrome; Urotensin-II-mediated signaling pathway; DNA damage response" "Golgi Cisternae Pericentriolar Stack Reorganization; AURKA Activation by TPX2; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; PKR-mediated signaling; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; Regulation of TP53 Degradation; APC/C:Cdc20 mediated degradation of Cyclin B; Phosphorylation of the APC/C; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Transcriptional regulation by RUNX2; Ovarian tumor domain proteases; MASTL Facilitates Mitotic Progression; E2F-enabled inhibition of pre-replication complex formation; MAPK3 (ERK1) activation; Condensation of Prophase Chromosomes; G1/S-Specific Transcription; Initiation of Nuclear Envelope (NE) Reformation; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint; Depolymerization of the Nuclear Lamina; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes; Phosphorylation of Emi1" "50" "0" "1.088" "1.123" "1.113" "1.295" "1.136" "1.019" "0.937" "0.935" "1.584" "146.5" "159.4" "164.5" "163.0" "189.7" "166.4" "149.2" "137.3" "137.0" "232.0" "" "" "" "" "" "" "" "" "" "" "77.6" "88.4" "94.2" "75.1" "102.6" "92.5" "87.8" "75.0" "76.9" "232.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4915588766185396896" "False" "High" "IsMasterProtein" "Q86U44" "N6-adenosine-methyltransferase catalytic subunit OS=Homo sapiens OX=9606 GN=METTL3 PE=1 SV=2" "0.000" "False" "11.735" "5" "3" "5" "3" "580" "64.4" "6.42" "12.01" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05063" "56339" "ENSG00000165819" "METTL3" "hsa:56339; O14736; Q86U44; Q86V05; Q9HB32" "mRNA processing" "Processing of Capped Intron-Containing Pre-mRNA" "2" "0" "0.978" "1.017" "0.930" "0.999" "1.013" "1.000" "1.055" "0.951" "0.749" "617.9" "604.3" "628.2" "574.4" "617.2" "626.1" "618.1" "651.8" "587.8" "462.8" "" "" "" "" "" "" "" "" "" "" "327.2" "335.1" "359.7" "264.5" "333.9" "348.3" "363.7" "355.8" "329.7" "462.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6734575471453550747" "False" "High" "IsMasterProtein" "Q6FI81" "Anamorsin OS=Homo sapiens OX=9606 GN=CIAPIN1 PE=1 SV=2" "0.000" "False" "11.729" "13" "4" "5" "4" "312" "33.6" "5.62" "14.58" "4" "cell organization and biogenesis;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf05093, Pf20922" "57019" "ENSG00000005194" "CIAPIN1" "A8K8B6; hsa:57019; O75206; O75207; Q6FI81; Q9H0W1; Q9P1L7" "" "Cytosolic iron-sulfur cluster assembly" "1" "0" "1.007" "0.982" "1.137" "1.027" "1.127" "1.193" "0.830" "1.019" "1.257" "74.1" "74.6" "72.7" "84.2" "76.0" "83.4" "88.3" "61.5" "75.4" "93.1" "" "" "" "" "" "" "" "" "" "" "39.2" "41.3" "41.6" "38.8" "41.1" "46.4" "52.0" "33.6" "42.3" "93.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6265096555801149049" "False" "High" "IsMasterProtein" "P06132" "Uroporphyrinogen decarboxylase OS=Homo sapiens OX=9606 GN=UROD PE=1 SV=2" "0.000" "False" "11.723" "12" "4" "6" "4" "367" "40.8" "6.14" "13.76" "4" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01208" "7389" "ENSG00000126088" "UROD" "A8K762; hsa:7389; P06132; Q16863; Q16883; Q53YB8; Q53ZP6; Q6IB28; Q9BUZ0" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "Heme biosynthesis" "3" "0" "0.934" "0.946" "1.077" "0.935" "0.861" "1.022" "1.010" "0.918" "0.563" "273.3" "255.3" "258.4" "294.4" "255.7" "235.3" "279.3" "276.2" "250.9" "153.8" "" "" "" "" "" "" "" "" "" "" "144.7" "141.6" "148.0" "135.6" "138.3" "130.9" "164.4" "150.7" "140.8" "153.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4711793945183504944" "False" "High" "IsMasterProtein" "P23434" "Glycine cleavage system H protein, mitochondrial OS=Homo sapiens OX=9606 GN=GCSH PE=1 SV=2" "0.000" "False" "11.717" "17" "2" "4" "2" "173" "18.9" "4.88" "12.20" "2" "protein metabolism;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01597" "2653" "ENSG00000140905; ENSG00000291958" "GCSH" "hsa:2653; P23434; Q9H1E9" "" "Glycine degradation" "2" "0" "0.919" "1.062" "0.924" "0.976" "0.942" "0.915" "1.016" "0.865" "0.482" "455.4" "418.3" "483.6" "420.7" "444.6" "429.1" "416.9" "462.6" "393.9" "219.4" "" "" "" "" "" "" "" "" "" "" "241.1" "231.9" "277.0" "193.7" "240.5" "238.7" "245.4" "252.5" "221.0" "219.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2874212812822634582" "False" "High" "IsMasterProtein" "Q7Z3T8" "Zinc finger FYVE domain-containing protein 16 OS=Homo sapiens OX=9606 GN=ZFYVE16 PE=1 SV=3" "0.000" "False" "11.714" "3" "4" "4" "4" "1539" "168.8" "4.82" "7.56" "4" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363, Pf11979" "9765" "ENSG00000039319" "ZFYVE16" "hsa:9765; O15023; Q5H9U2; Q7LAU7; Q7Z3T8; Q86T69; Q8N5L3; Q8NEK3" "TGF-beta signaling pathway" "Signaling by BMP" "2" "0" "1.028" "1.019" "1.169" "1.152" "0.949" "1.003" "0.941" "1.039" "0.590" "355.2" "365.2" "361.9" "415.2" "409.2" "337.1" "356.3" "334.2" "369.1" "209.4" "" "" "" "" "" "" "" "" "" "" "188.1" "202.5" "207.2" "191.2" "221.4" "187.5" "209.7" "182.4" "207.1" "209.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2201882454177381815" "False" "High" "IsMasterProtein" "P63241" "Eukaryotic translation initiation factor 5A-1 OS=Homo sapiens OX=9606 GN=EIF5A PE=1 SV=2" "0.000" "False" "11.709" "13" "3" "8" "3" "154" "16.8" "5.24" "17.89" "3" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf01287, Pf21485" "1984" "ENSG00000132507; ENSG00000288145" "EIF5A" "A8K9A0; D3DTP2; hsa:1984; P10159; P63241; Q16182; Q7L7L3; Q7Z4L1; Q9D0G2" "Translation factors; eIF5A regulation in response to inhibition of the nuclear export system" "Hypusine synthesis from eIF5A-lysine" "3" "0" "1.015" "1.025" "1.098" "0.991" "0.962" "0.975" "0.918" "0.991" "1.471" "537.4" "545.7" "550.9" "590.2" "532.5" "517.0" "523.8" "493.2" "532.6" "790.6" "" "" "" "" "" "" "" "" "" "" "284.6" "302.5" "315.5" "271.8" "288.1" "287.6" "308.3" "269.2" "298.8" "790.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1749791296604860145" "False" "High" "IsMasterProtein" "Q9BTE6" "Alanyl-tRNA editing protein Aarsd1 OS=Homo sapiens OX=9606 GN=AARSD1 PE=1 SV=2" "0.000" "False" "11.689" "7" "3" "4" "3" "412" "45.5" "6.42" "11.73" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf07973" "100885850; 80755" "ENSG00000108825; ENSG00000266967" "AARSD1" "B4DI73; hsa:100885850; hsa:80755; Q9BTE6" "" "" "0" "0" "1.379" "1.278" "1.354" "1.337" "1.424" "1.381" "0.930" "1.404" "6.754" "103.5" "142.7" "132.2" "140.1" "138.3" "147.3" "142.9" "96.2" "145.3" "698.9" "" "" "" "" "" "" "" "" "" "" "54.8" "79.1" "75.7" "64.5" "74.8" "82.0" "84.1" "52.5" "81.5" "698.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3146791204946970239" "False" "High" "IsMasterProtein" "Q9Y6W5" "Actin-binding protein WASF2 OS=Homo sapiens OX=9606 GN=WASF2 PE=1 SV=3" "0.000" "False" "11.688" "6" "4" "4" "4" "498" "54.3" "5.53" "11.58" "4" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf02205" "10163" "ENSG00000158195" "WASF2" "B4DZN0; hsa:10163; O60794; Q9UDY7; Q9Y6W5" "Regulation of actin cytoskeleton" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs" "8" "0" "1.057" "0.886" "0.872" "0.977" "0.943" "0.895" "0.837" "0.905" "0.981" "866.0" "915.7" "767.5" "755.0" "845.9" "817.1" "775.1" "724.9" "784.1" "850.0" "" "" "" "" "" "" "" "" "" "" "458.6" "507.7" "439.6" "347.7" "457.7" "454.5" "456.2" "395.7" "439.9" "850.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3430961605673792526" "False" "High" "IsMasterProtein" "Q13033" "Striatin-3 OS=Homo sapiens OX=9606 GN=STRN3 PE=1 SV=3" "0.000" "False" "11.687" "3" "2" "3" "2" "797" "87.2" "5.36" "7.89" "2" "other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00400, Pf08232" "29966" "ENSG00000196792" "STRN3" "A2RTX7; A6NHZ7; hsa:29966; Q13033; Q9NRA5" "" "" "0" "0" "0.930" "0.800" "1.053" "1.018" "0.771" "1.180" "1.056" "1.009" "0.676" "92.0" "85.5" "73.6" "96.9" "93.7" "70.9" "108.5" "97.2" "92.8" "62.2" "" "" "" "" "" "" "" "" "" "" "48.7" "47.4" "42.1" "44.6" "50.7" "39.4" "63.9" "53.0" "52.1" "62.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1681644365065118187" "False" "High" "IsMasterProtein" "Q8IVS2" "Malonyl-CoA-acyl carrier protein transacylase, mitochondrial OS=Homo sapiens OX=9606 GN=MCAT PE=1 SV=2" "0.000" "False" "11.676" "9" "4" "6" "4" "390" "42.9" "8.72" "17.68" "4" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00698" "27349" "ENSG00000100294" "MCAT" "B0QY72; O95510; O95511; Q8IVS2" "Mitochondrial fatty acid synthesis pathway" "Mitochondrial Fatty Acid Beta-Oxidation" "2" "0" "1.036" "1.048" "1.068" "1.084" "1.084" "1.002" "1.055" "1.023" "0.665" "499.5" "517.3" "523.3" "533.5" "541.6" "541.5" "500.7" "527.0" "511.2" "332.1" "" "" "" "" "" "" "" "" "" "" "264.5" "286.8" "299.7" "245.7" "293.0" "301.2" "294.7" "287.7" "286.8" "332.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3945672141617060885" "False" "High" "IsMasterProtein" "Q9P2E9" "Ribosome-binding protein 1 OS=Homo sapiens OX=9606 GN=RRBP1 PE=1 SV=5" "0.000" "False" "11.675" "13" "4" "4" "4" "1410" "152.4" "8.60" "9.99" "4" "protein metabolism;other metabolic processes;transport" "other membranes;ER/Golgi;translational apparatus" "other molecular function" "Pf05104" "6238" "ENSG00000125844" "RRBP1" "A0A0A0MRV0; A2A2S6; A6NCN6; hsa:6238; O75300; O75301; Q5W165; Q96SB2; Q9BWP1; Q9H476; Q9P2E9" "Ectoderm differentiation" "Signaling by ALK fusions and activated point mutants" "2" "0" "1.032" "1.122" "1.092" "1.012" "0.974" "0.943" "1.115" "1.049" "0.735" "308.4" "318.4" "346.0" "337.0" "312.2" "300.6" "290.9" "344.0" "323.4" "226.6" "" "" "" "" "" "" "" "" "" "" "163.3" "176.5" "198.2" "155.2" "168.9" "167.2" "171.2" "187.8" "181.4" "226.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8115328096255325213" "False" "High" "IsMasterProtein" "P29966" "Myristoylated alanine-rich C-kinase substrate OS=Homo sapiens OX=9606 GN=MARCKS PE=1 SV=4" "0.000" "False" "11.672" "8" "2" "3" "2" "332" "31.5" "4.45" "11.41" "2" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02063" "4082" "ENSG00000277443" "MARCKS" "E1P560; hsa:4082; P29966; Q2LA83; Q5TDB7" "Brain-derived neurotrophic factor (BDNF) signaling pathway" "Acetylcholine regulates insulin secretion" "2" "0" "0.979" "1.023" "1.005" "0.891" "0.886" "0.848" "1.007" "0.967" "0.451" "528.4" "517.5" "540.7" "531.2" "470.7" "468.4" "447.9" "532.0" "511.1" "238.4" "" "" "" "" "" "" "" "" "" "" "279.8" "286.9" "309.7" "244.6" "254.7" "260.5" "263.6" "290.4" "286.7" "238.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1205660111365886564" "False" "High" "IsMasterProtein" "Q92599" "Septin-8 OS=Homo sapiens OX=9606 GN=SEPTIN8 PE=1 SV=4" "0.000" "False" "11.671" "7" "4" "10" "3" "483" "55.7" "6.28" "19.82" "4" "cell cycle OR cell proliferation;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00735" "23176" "ENSG00000164402" "SEPTIN8" "A6NC65; A6NKP6; F6W7K9; hsa:23176; Q8IX36; Q8IX37; Q92599; Q9BVB3" "22q11.2 copy number variation syndrome" "" "1" "0" "0.981" "0.987" "0.931" "0.978" "1.041" "1.026" "1.018" "1.006" "0.533" "575.7" "564.8" "568.3" "535.8" "563.0" "599.3" "590.6" "585.9" "578.9" "307.1" "" "" "" "" "" "" "" "" "" "" "304.9" "313.1" "325.5" "246.8" "304.6" "333.3" "347.6" "319.8" "324.8" "307.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5641944312381893453" "False" "High" "IsMasterProtein" "Q8IYB7" "DIS3-like exonuclease 2 OS=Homo sapiens OX=9606 GN=DIS3L2 PE=1 SV=4" "0.000" "False" "11.667" "5" "4" "4" "4" "885" "99.2" "6.10" "8.29" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf00773, Pf17216, Pf17849, Pf17877" "129563" "ENSG00000144535" "DIS3L2" "hsa:129563; Q53S79; Q580W6; Q5XKH0; Q69YG5; Q6AW99; Q7Z4T6; Q8IYB7; Q8N9K9" "" "Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "1" "0" "1.066" "1.028" "1.027" "1.125" "1.151" "1.038" "1.078" "1.132" "1.236" "329.7" "351.6" "338.9" "338.5" "370.8" "379.5" "342.2" "355.5" "373.1" "407.7" "" "" "" "" "" "" "" "" "" "" "174.6" "195.0" "194.1" "155.9" "200.6" "211.1" "201.4" "194.1" "209.3" "407.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5464068146291938331" "False" "High" "IsMasterProtein" "P49840" "Glycogen synthase kinase-3 alpha OS=Homo sapiens OX=9606 GN=GSK3A PE=1 SV=2" "0.000" "False" "11.661" "5" "2" "4" "2" "483" "50.9" "8.75" "11.52" "2" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "2931" "ENSG00000105723" "GSK3A" "hsa:2931; O14959; P49840" "IL-5 signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; Wnt signaling pathway; Regulation of apoptosis by parathyroid hormone-related protein; Angiopoietin-like protein 8 regulatory pathway; Nonalcoholic fatty liver disease; Insulin signaling; Glycogen synthesis and degradation; HDAC6 interactions in the central nervous system" "Constitutive Signaling by AKT1 E17K in Cancer; XBP1(S) activates chaperone genes; AKT phosphorylates targets in the cytosol; Suppression of apoptosis; Maturation of nucleoprotein; Maturation of nucleoprotein" "18" "0" "1.085" "0.986" "1.071" "1.156" "1.166" "1.150" "1.122" "0.990" "0.930" "154.3" "167.4" "152.1" "165.2" "178.5" "179.9" "177.5" "173.1" "152.8" "143.6" "" "" "" "" "" "" "" "" "" "" "81.7" "92.8" "87.1" "76.1" "96.6" "100.1" "104.4" "94.5" "85.7" "143.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8333462526308289964" "False" "High" "IsMasterProtein" "O60671" "Cell cycle checkpoint protein RAD1 OS=Homo sapiens OX=9606 GN=RAD1 PE=1 SV=1" "0.000" "False" "11.649" "11" "4" "5" "4" "282" "31.8" "4.83" "14.17" "4" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02144" "5810" "ENSG00000113456" "RAD1" "hsa:5810; O60671; O75572; O95304; Q1W161; Q5KSM0; Q5KSM1; Q9UEP1" "miRNA regulation of DNA damage response; ATR signaling; DNA damage response" "Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "10" "0" "1.003" "0.939" "0.990" "1.093" "1.104" "1.074" "0.950" "1.073" "0.961" "600.8" "602.4" "564.2" "594.9" "656.9" "663.0" "645.3" "570.8" "644.9" "577.4" "" "" "" "" "" "" "" "" "" "" "318.1" "334.0" "323.1" "274.0" "355.4" "368.8" "379.8" "311.6" "361.8" "577.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1790933947294059226" "False" "High" "IsMasterProtein" "Q9H477" "Ribokinase OS=Homo sapiens OX=9606 GN=RBKS PE=1 SV=1" "0.000" "False" "11.637" "10" "3" "4" "3" "322" "34.1" "5.05" "11.67" "3" "other metabolic processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00294" "64080" "ENSG00000171174" "RBKS" "A9UK04; B4DV96; hsa:64080; Q9H477" "" "Pentose phosphate pathway" "1" "0" "0.954" "1.007" "0.947" "1.038" "1.131" "1.139" "1.020" "1.083" "0.592" "240.3" "229.4" "242.1" "227.5" "249.4" "271.8" "273.8" "245.1" "260.2" "142.2" "" "" "" "" "" "" "" "" "" "" "127.2" "127.2" "138.6" "104.8" "135.0" "151.2" "161.1" "133.8" "146.0" "142.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8321429417116917544" "False" "High" "IsMasterProtein" "P07339" "Cathepsin D OS=Homo sapiens OX=9606 GN=CTSD PE=1 SV=1" "0.000" "False" "11.632" "11" "5" "5" "5" "412" "44.5" "6.54" "11.00" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00026, Pf07966" "1509" "ENSG00000117984" "CTSD" "hsa:1509; P07339; Q6IB57" "Prolactin signaling pathway; 8p23.1 copy number variation syndrome" "Neutrophil degranulation; MHC class II antigen presentation; Collagen degradation; Estrogen-dependent gene expression; Insulin receptor recycling; Metabolism of Angiotensinogen to Angiotensins" "8" "0" "1.105" "0.974" "1.077" "1.159" "1.138" "1.105" "1.030" "1.098" "0.815" "508.7" "562.4" "495.7" "548.2" "589.8" "579.0" "562.1" "524.2" "558.5" "414.6" "" "" "" "" "" "" "" "" "" "" "269.4" "311.8" "283.9" "252.4" "319.1" "322.1" "330.8" "286.2" "313.3" "414.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5145837311521029190" "False" "High" "IsMasterProtein" "Q8N183" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 OS=Homo sapiens OX=9606 GN=NDUFAF2 PE=1 SV=1" "0.000" "False" "11.631" "21" "3" "3" "3" "169" "19.8" "8.97" "8.82" "3" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf05071" "91942" "ENSG00000164182" "NDUFAF2" "A8K5I1; hsa:91942; Q8N183" "SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "Complex I biogenesis" "2" "0" "0.911" "0.955" "0.799" "0.926" "0.935" "0.811" "0.955" "0.923" "0.604" "416.3" "379.5" "397.7" "332.6" "385.5" "389.1" "337.8" "397.6" "384.2" "251.4" "" "" "" "" "" "" "" "" "" "" "220.4" "210.4" "227.8" "153.2" "208.6" "216.4" "198.8" "217.0" "215.5" "251.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3324031393637842436" "False" "High" "IsMasterProtein" "P49458" "Signal recognition particle 9 kDa protein OS=Homo sapiens OX=9606 GN=SRP9 PE=1 SV=2" "0.000" "False" "11.630" "37" "4" "7" "4" "86" "10.1" "7.97" "16.13" "4" "other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf05486" "6726" "ENSG00000143742" "SRP9" "A8K0N0; hsa:6726; P49458; Q6NVX0; Q8WTW0" "" "SRP-dependent cotranslational protein targeting to membrane" "1" "0" "0.927" "0.967" "0.881" "0.922" "0.841" "0.938" "0.956" "0.866" "0.466" "1166.2" "1081.2" "1127.2" "1027.1" "1074.9" "981.3" "1094.1" "1114.6" "1010.2" "543.9" "" "" "" "" "" "" "" "" "" "" "617.5" "599.5" "645.5" "473.0" "581.6" "545.8" "643.9" "608.4" "566.7" "543.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2846560637843554470" "False" "High" "IsMasterProtein" "O14579" "Coatomer subunit epsilon OS=Homo sapiens OX=9606 GN=COPE PE=1 SV=3" "0.000" "False" "11.608" "6" "3" "3" "3" "308" "34.5" "5.12" "9.93" "3" "transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus" "other molecular function" "Pf04733" "11316" "ENSG00000105669" "COPE" "A6NE29; A6NKA3; hsa:11316; O14579; O76097; Q6IBB8; Q9UGP6" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "2" "0" "1.210" "1.139" "1.097" "1.137" "1.174" "1.123" "1.150" "1.127" "1.200" "131.5" "159.1" "149.8" "144.3" "149.6" "154.4" "147.6" "151.3" "148.2" "157.9" "" "" "" "" "" "" "" "" "" "" "69.6" "88.2" "85.8" "66.4" "80.9" "85.9" "86.9" "82.6" "83.1" "157.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-77584884133553683" "False" "High" "IsMasterProtein" "Q9UMY4" "Sorting nexin-12 OS=Homo sapiens OX=9606 GN=SNX12 PE=1 SV=4" "0.000" "False" "11.606" "21" "3" "3" "2" "162" "18.9" "8.44" "8.07" "3" "transport;other biological processes" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf00787" "29934" "ENSG00000147164" "SNX12" "F8W8K5; hsa:29934; Q8WUG9; Q9UMY4" "" "" "0" "0" "1.086" "1.137" "1.182" "0.968" "0.957" "1.051" "1.248" "0.955" "1.890" "102.1" "110.9" "116.2" "120.8" "98.8" "97.8" "107.4" "127.5" "97.6" "193.1" "" "" "" "" "" "" "" "" "" "" "54.1" "61.5" "66.5" "55.6" "53.5" "54.4" "63.2" "69.6" "54.7" "193.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2850205802309277585" "False" "High" "IsMasterProtein" "Q96DE0" "U8 snoRNA-decapping enzyme OS=Homo sapiens OX=9606 GN=NUDT16 PE=1 SV=2" "0.000" "False" "11.601" "15" "3" "4" "2" "195" "21.3" "6.89" "12.04" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293" "131870" "ENSG00000198585" "NUDT16" "B4E3B4; E9PED4; F5GYJ1; hsa:131870; Q96DE0; Q96N82" "" "Phosphate bond hydrolysis by NUDT proteins" "1" "1" "1.152" "0.943" "1.280" "1.106" "1.061" "1.289" "1.191" "1.083" "0.736" "80.2" "92.4" "75.6" "102.6" "88.7" "85.1" "103.3" "95.5" "86.8" "59.0" "" "" "" "" "" "" "" "" "" "" "42.4" "51.2" "43.3" "47.3" "48.0" "47.3" "60.8" "52.1" "48.7" "59.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9211506236520866705" "False" "High" "IsMasterProtein" "O76071" "Probable cytosolic iron-sulfur protein assembly protein CIAO1 OS=Homo sapiens OX=9606 GN=CIAO1 PE=1 SV=1" "0.000" "False" "11.599" "7" "3" "5" "3" "339" "37.8" "4.97" "15.58" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;other cell component" "" "Pf00400" "9391" "ENSG00000144021" "CIAO1" "A0MNN9; hsa:9391; O76071; Q53FM5" "2q11.2 copy number variation syndrome" "Cytosolic iron-sulfur cluster assembly" "2" "0" "0.974" "0.873" "1.006" "0.982" "0.839" "0.911" "0.887" "1.007" "0.687" "169.4" "165.1" "148.0" "170.5" "166.3" "142.2" "154.3" "150.2" "170.7" "116.4" "" "" "" "" "" "" "" "" "" "" "89.7" "91.5" "84.7" "78.5" "90.0" "79.1" "90.8" "82.0" "95.7" "116.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2870938991305949224" "False" "High" "IsMasterProtein" "P15848" "Arylsulfatase B OS=Homo sapiens OX=9606 GN=ARSB PE=1 SV=1" "0.000" "False" "11.572" "5" "3" "5" "3" "533" "59.6" "8.21" "16.56" "3" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00884" "411" "ENSG00000113273" "ARSB" "B2RC20; hsa:411; P15848; Q8N322; Q9UDI9" "Glycosaminoglycan degradation" "Neutrophil degranulation; CS/DS degradation; Glycosphingolipid catabolism; The activation of arylsulfatases; MPS VI - Maroteaux-Lamy syndrome" "6" "0" "0.908" "0.979" "0.968" "0.919" "0.963" "0.979" "1.008" "1.062" "0.972" "379.1" "344.2" "371.0" "366.8" "348.5" "365.0" "371.3" "382.2" "402.4" "368.3" "" "" "" "" "" "" "" "" "" "" "200.7" "190.8" "212.5" "168.9" "188.6" "203.0" "218.5" "208.6" "225.8" "368.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6622169396848351928" "False" "High" "IsMasterProtein" "Q8NFF5" "FAD synthase OS=Homo sapiens OX=9606 GN=FLAD1 PE=1 SV=1" "0.000" "False" "11.551" "6" "4" "4" "4" "587" "65.2" "6.93" "10.98" "4" "other metabolic processes" "plasma membrane;other membranes;cytosol;mitochondrion" "other molecular function" "Pf00994, Pf01507" "80308" "ENSG00000160688" "FLAD1" "hsa:80308; Q8N5J1; Q8N686; Q8NFF5; Q8WU93; Q8WUJ4; Q96CR8; Q99764; Q9HBN6" "Selenium micronutrient network; Folate metabolism" "Vitamin B2 (riboflavin) metabolism" "3" "0" "1.002" "0.909" "0.929" "1.044" "0.914" "0.920" "0.778" "0.844" "1.519" "198.4" "198.8" "180.3" "184.3" "207.1" "181.4" "182.5" "154.4" "167.4" "301.5" "" "" "" "" "" "" "" "" "" "" "105.0" "110.2" "103.3" "84.9" "112.0" "100.9" "107.4" "84.3" "93.9" "301.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6802815428408388451" "False" "High" "IsMasterProtein" "Q9UK99" "F-box only protein 3 OS=Homo sapiens OX=9606 GN=FBXO3 PE=1 SV=3" "0.000" "False" "11.539" "8" "3" "3" "3" "471" "54.5" "5.00" "4.88" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00646, Pf04379, Pf09346" "26273" "ENSG00000110429" "FBXO3" "B3KY16; D3DR05; hsa:26273; Q86X90; Q9H0V2; Q9NUX2; Q9UK99" "" "" "0" "0" "1.087" "1.091" "1.040" "1.140" "1.114" "1.051" "1.082" "1.066" "0.776" "135.1" "146.7" "147.3" "140.5" "154.0" "150.4" "141.9" "146.1" "144.0" "104.8" "" "" "" "" "" "" "" "" "" "" "71.5" "81.4" "84.4" "64.7" "83.3" "83.7" "83.5" "79.8" "80.8" "104.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2599348248423270713" "False" "High" "IsMasterProtein" "P23258" "Tubulin gamma-1 chain OS=Homo sapiens OX=9606 GN=TUBG1 PE=1 SV=2" "0.000" "False" "11.536" "8" "3" "5" "3" "451" "51.1" "6.14" "14.98" "3" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "7283" "ENSG00000131462" "TUBG1" "hsa:7283; P23258; Q53X79; Q9BW59" "Alstrom syndrome" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "8" "0" "1.121" "1.021" "1.206" "1.060" "1.113" "1.091" "1.071" "1.074" "1.585" "207.5" "232.6" "211.9" "250.2" "219.9" "231.1" "226.3" "222.2" "222.9" "328.9" "" "" "" "" "" "" "" "" "" "" "109.9" "129.0" "121.4" "115.2" "119.0" "128.5" "133.2" "121.3" "125.0" "328.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4122244859069195901" "False" "High" "IsMasterProtein" "Q9NVM6" "DnaJ homolog subfamily C member 17 OS=Homo sapiens OX=9606 GN=DNAJC17 PE=1 SV=1" "0.000" "False" "11.529" "11" "3" "3" "3" "304" "34.7" "8.53" "7.45" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf00226" "55192" "ENSG00000104129" "DNAJC17" "hsa:55192; Q9NVM6" "" "" "0" "0" "0.931" "0.965" "0.993" "1.200" "0.894" "0.923" "1.445" "1.452" "0.950" "66.2" "61.6" "63.9" "65.8" "79.4" "59.2" "61.1" "95.7" "96.2" "62.9" "" "" "" "" "" "" "" "" "" "" "35.1" "34.2" "36.6" "30.3" "43.0" "32.9" "36.0" "52.2" "54.0" "62.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "76993751311903605" "False" "High" "IsMasterProtein" "Q9GZZ9" "Ubiquitin-like modifier-activating enzyme 5 OS=Homo sapiens OX=9606 GN=UBA5 PE=1 SV=1" "0.000" "False" "11.527" "11" "3" "3" "3" "404" "44.8" "4.84" "9.40" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00899" "79876" "ENSG00000081307" "UBA5" "A6NJL3; D3DNC8; hsa:79876; Q96ST1; Q9GZZ9" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.874" "0.869" "0.823" "0.973" "0.959" "0.931" "0.975" "0.856" "0.642" "121.2" "106.0" "105.3" "99.7" "117.9" "116.2" "112.8" "118.2" "103.8" "77.8" "" "" "" "" "" "" "" "" "" "" "64.2" "58.8" "60.3" "45.9" "63.8" "64.6" "66.4" "64.5" "58.2" "77.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6238619609280539619" "False" "High" "IsMasterProtein" "Q9NZW5" "Protein PALS2 OS=Homo sapiens OX=9606 GN=PALS2 PE=1 SV=2" "0.000" "False" "11.518" "7" "4" "4" "4" "540" "61.1" "6.18" "9.23" "4" "cell organization and biogenesis" "plasma membrane;other membranes;other cell component" "" "Pf00595, Pf00625, Pf02828, Pf07653" "51678" "ENSG00000105926" "PALS2" "A4D157; hsa:51678; Q9H0E1; Q9NZW5" "" "" "0" "0" "0.867" "0.803" "1.044" "0.806" "0.976" "0.801" "0.647" "0.803" "1.832" "81.9" "71.0" "65.8" "85.5" "66.1" "79.9" "65.7" "53.0" "65.8" "150.1" "" "" "" "" "" "" "" "" "" "" "43.4" "39.4" "37.7" "39.4" "35.7" "44.5" "38.6" "28.9" "36.9" "150.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "193140464994973163" "False" "High" "IsMasterProtein" "P49711" "Transcriptional repressor CTCF OS=Homo sapiens OX=9606 GN=CTCF PE=1 SV=1" "0.000" "False" "11.503" "5" "4" "5" "4" "727" "82.7" "6.96" "13.88" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "10664" "ENSG00000102974" "CTCF" "B5MC38; hsa:10664; P49711; Q53XI7; Q59EL8" "MECP2 and associated Rett syndrome; Prion disease pathway; Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors; Sudden infant death syndrome (SIDS) susceptibility pathways" "Activation of anterior HOX genes in hindbrain development during early embryogenesis" "5" "0" "1.049" "1.064" "0.934" "0.920" "0.984" "0.952" "0.988" "1.047" "1.371" "226.4" "237.4" "240.9" "211.5" "208.2" "222.8" "215.4" "223.7" "237.0" "310.4" "" "" "" "" "" "" "" "" "" "" "119.9" "131.6" "138.0" "97.4" "112.6" "123.9" "126.8" "122.1" "132.9" "310.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "588939397575272440" "False" "High" "IsMasterProtein" "Q7L2J0" "7SK snRNA methylphosphate capping enzyme OS=Homo sapiens OX=9606 GN=MEPCE PE=1 SV=1" "0.000" "False" "11.491" "4" "2" "2" "2" "689" "74.3" "9.57" "8.01" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06859" "56257" "ENSG00000146834" "MEPCE" "B3KP86; D6W5V7; hsa:56257; Q7L2J0; Q9NPD4" "IL-18 signaling pathway; 1p36 copy number variation syndrome" "" "2" "0" "1.010" "0.959" "0.496" "0.911" "1.161" "1.472" "1.271" "1.188" "0.730" "18.1" "18.2" "17.3" "9.0" "16.5" "21.0" "26.6" "23.0" "21.5" "13.2" "" "" "" "" "" "" "" "" "" "" "9.6" "10.1" "9.9" "4.1" "8.9" "11.7" "15.6" "12.5" "12.0" "13.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-832536973652725080" "False" "High" "IsMasterProtein" "Q96C90" "Protein phosphatase 1 regulatory subunit 14B OS=Homo sapiens OX=9606 GN=PPP1R14B PE=1 SV=3" "0.000" "False" "11.476" "17" "2" "4" "2" "147" "15.9" "4.86" "13.38" "2" "stress response;other biological processes" "other cell component" "enzyme regulator activity" "Pf05361" "26472" "ENSG00000173457" "PPP1R14B" "hsa:26472; Q504S7; Q7KZD7; Q96C90" "" "" "0" "0" "1.022" "1.204" "1.169" "1.015" "1.124" "1.079" "1.070" "0.909" "0.606" "112.2" "114.7" "135.1" "131.2" "113.9" "126.1" "121.1" "120.1" "102.0" "68.0" "" "" "" "" "" "" "" "" "" "" "59.4" "63.6" "77.4" "60.4" "61.6" "70.2" "71.3" "65.6" "57.2" "68.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7388585802174213380" "False" "High" "IsMasterProtein" "Q06187" "Tyrosine-protein kinase BTK OS=Homo sapiens OX=9606 GN=BTK PE=1 SV=3" "0.000" "False" "11.475" "5" "4" "5" "4" "659" "76.2" "7.77" "12.72" "4" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf00169, Pf00779, Pf07714" "695" "ENSG00000010671" "BTK" "B2RAW1; hsa:695; Q06187; Q32ML5" "IL-5 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; Kit receptor signaling pathway; 7q11.23 copy number variation syndrome; Genetic causes of porto-sinusoidal vascular disease" "FCGR3A-mediated phagocytosis; Potential therapeutics for SARS; ER-Phagosome pathway; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated Ca+2 mobilization; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; G alpha (12/13) signalling events; G alpha (q) signalling events; RHO GTPases Activate WASPs and WAVEs; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); DAP12 signaling; G beta:gamma signalling through BTK" "20" "0" "0.997" "1.081" "1.246" "1.099" "0.985" "1.143" "0.230" "0.996" "10.669" "203.6" "203.0" "220.1" "253.6" "223.8" "200.5" "232.7" "46.9" "202.9" "2172.3" "" "" "" "" "" "" "" "" "" "" "107.8" "112.6" "126.1" "116.8" "121.1" "111.6" "136.9" "25.6" "113.8" "2172.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "653544174487068262" "False" "High" "IsMasterProtein" "O00479" "High mobility group nucleosome-binding domain-containing protein 4 OS=Homo sapiens OX=9606 GN=HMGN4 PE=1 SV=3" "0.000" "False" "11.474" "27" "3" "5" "3" "90" "9.5" "10.48" "15.33" "3" "cell organization and biogenesis" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "10473" "ENSG00000182952; ENSG00000292175" "HMGN4" "B2R4I6; hsa:10473; O00479; Q53XL9" "" "" "0" "0" "1.015" "1.030" "1.147" "0.857" "0.896" "0.893" "1.085" "0.932" "0.398" "937.8" "952.1" "966.1" "1075.8" "803.5" "839.8" "837.1" "1017.6" "873.7" "373.6" "" "" "" "" "" "" "" "" "" "" "496.5" "527.9" "553.3" "495.5" "434.7" "467.2" "492.6" "555.5" "490.1" "373.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8561643854279228847" "False" "High" "IsMasterProtein" "P15927" "Replication protein A 32 kDa subunit OS=Homo sapiens OX=9606 GN=RPA2 PE=1 SV=1" "0.000" "False" "11.470" "10" "3" "11" "3" "270" "29.2" "6.15" "19.61" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08784" "6118" "ENSG00000117748" "RPA2" "hsa:6118; P15927; Q52II0; Q5TEI9; Q5TEJ5" "miRNA regulation of DNA damage response; Retinoblastoma gene in cancer; G1 to S cell cycle control; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair; DNA damage response" "Termination of translesion DNA synthesis; Presynaptic phase of homologous DNA pairing and strand exchange; HDR through Homologous Recombination (HRR); Meiotic recombination; Regulation of HSF1-mediated heat shock response; Fanconi Anemia Pathway; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; HSF1 activation; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "38" "0" "1.010" "1.044" "1.144" "1.248" "1.325" "1.386" "1.436" "1.206" "1.184" "359.4" "363.0" "375.2" "411.0" "448.7" "476.4" "498.0" "516.1" "433.4" "425.6" "" "" "" "" "" "" "" "" "" "" "190.3" "201.3" "214.9" "189.3" "242.8" "265.0" "293.1" "281.7" "243.2" "425.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3092682979585279254" "False" "High" "IsMasterProtein" "Q96BP3" "Peptidylprolyl isomerase domain and WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=PPWD1 PE=1 SV=1" "0.000" "False" "11.469" "5" "4" "4" "4" "646" "73.5" "7.15" "10.16" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00160, Pf00400" "23398" "ENSG00000113593" "PPWD1" "B4DWR9; hsa:23398; Q15002; Q7KZ89; Q96BP3" "" "mRNA Splicing - Major Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3318152306764108447" "False" "High" "IsMasterProtein" "O60563" "Cyclin-T1 OS=Homo sapiens OX=9606 GN=CCNT1 PE=1 SV=1" "0.000" "False" "11.453" "4" "3" "3" "3" "726" "80.6" "8.78" "9.23" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00134, Pf21797" "904" "ENSG00000129315" "CCNT1" "A9XU13; E7EX76; hsa:904; O60563; O60581" "Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interactions of Tat with host cellular proteins" "17" "0" "0.945" "0.938" "1.219" "1.088" "1.132" "1.278" "1.360" "1.317" "1.371" "242.1" "228.8" "227.1" "295.1" "263.3" "274.0" "309.4" "329.4" "318.9" "332.1" "" "" "" "" "" "" "" "" "" "" "128.2" "126.8" "130.1" "135.9" "142.5" "152.4" "182.1" "179.8" "178.9" "332.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-313217822058437387" "False" "High" "IsMasterProtein" "P55789" "FAD-linked sulfhydryl oxidase ALR OS=Homo sapiens OX=9606 GN=GFER PE=1 SV=2" "0.000" "False" "11.441" "12" "1" "1" "1" "205" "23.4" "7.62" "5.57" "1" "developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;mitochondrion" "signal transduction activity or receptor binding;other molecular function" "Pf04777" "2671" "ENSG00000127554; ENSG00000291944" "GFER" "hsa:2671; P55789; Q53YM6; Q8TAH6; Q9H290; Q9UK40" "" "Mitochondrial protein import" "1" "0" "1.276" "1.281" "1.207" "1.028" "0.954" "0.958" "1.462" "1.332" "0.606" "24.1" "30.7" "30.8" "29.1" "24.8" "23.0" "23.1" "35.2" "32.1" "14.6" "" "" "" "" "" "" "" "" "" "" "12.8" "17.0" "17.7" "13.4" "13.4" "12.8" "13.6" "19.2" "18.0" "14.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3913128170310311305" "False" "High" "IsMasterProtein" "O00487" "26S proteasome non-ATPase regulatory subunit 14 OS=Homo sapiens OX=9606 GN=PSMD14 PE=1 SV=1" "0.000" "False" "11.435" "14" "6" "8" "6" "310" "34.6" "6.52" "16.47" "6" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01398" "10213" "ENSG00000115233" "PSMD14" "B3KNW2; hsa:10213; O00176; O00487" "Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Metalloprotease DUBs" "64" "0" "0.941" "0.976" "0.953" "0.992" "0.984" "0.976" "0.910" "1.014" "0.630" "903.1" "850.2" "881.3" "860.7" "896.2" "888.8" "881.0" "822.0" "915.8" "569.0" "" "" "" "" "" "" "" "" "" "" "478.2" "471.4" "504.7" "396.4" "484.9" "494.4" "518.5" "448.7" "513.7" "569.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3928558694847449526" "False" "High" "IsMasterProtein" "Q9UBQ5" "Eukaryotic translation initiation factor 3 subunit K OS=Homo sapiens OX=9606 GN=EIF3K PE=1 SV=1" "0.000" "False" "11.415" "11" "2" "3" "2" "218" "25.0" "4.93" "8.67" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf10075" "27335" "ENSG00000178982; ENSG00000282986" "EIF3K" "A8K0I9; B7ZAM9; hsa:27335; Q96IQ0; Q9UBQ5; Q9Y6D1" "" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "6" "0" "1.109" "1.095" "1.186" "1.138" "1.115" "1.047" "1.028" "0.928" "0.590" "312.7" "346.8" "342.4" "370.7" "355.7" "348.5" "327.4" "321.5" "290.2" "184.6" "" "" "" "" "" "" "" "" "" "" "165.6" "192.3" "196.1" "170.7" "192.5" "193.9" "192.7" "175.5" "162.8" "184.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8597337933688242360" "False" "High" "IsMasterProtein" "P84243" "Histone H3.3 OS=Homo sapiens OX=9606 GN=H3-3B PE=1 SV=2" "0.000" "False" "11.406" "24" "4" "10" "2" "136" "15.3" "11.27" "28.84" "4" "cell organization and biogenesis;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "3020; 3021" "ENSG00000132475; ENSG00000163041" "H3-3A; H3-3B" "hsa:3020; hsa:3021; P06351; P33155; P84243; Q5VV55; Q5VV56; Q66I33; Q9V3W4" "Gastric cancer network 1; Histone modifications; Tumor suppressor activity of SMARCB1; Ciliary landscape; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; DYRK1A involvement regarding cell proliferation in brain development; 4p16.3 copy number variation; 5q35 copy number variation" "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Transcriptional regulation by small RNAs; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Amyloid fiber formation; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); Factors involved in megakaryocyte development and platelet production; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Condensation of Prophase Chromosomes; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Replacement of protamines by nucleosomes in the male pronucleus" "36" "0" "1.017" "1.016" "1.178" "0.983" "1.013" "0.882" "0.909" "0.898" "0.763" "508.1" "516.5" "516.5" "598.7" "499.3" "514.6" "448.0" "462.1" "456.2" "387.6" "" "" "" "" "" "" "" "" "" "" "269.1" "286.4" "295.8" "275.7" "270.1" "286.2" "263.6" "252.2" "255.9" "387.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7324571001266765675" "False" "High" "IsMasterProtein" "P29350" "Tyrosine-protein phosphatase non-receptor type 6 OS=Homo sapiens OX=9606 GN=PTPN6 PE=1 SV=1" "0.000" "False" "11.406" "6" "3" "4" "3" "595" "67.5" "7.78" "6.01" "3" "cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00017, Pf00102" "5777" "ENSG00000111679" "PTPN6" "A8K306; G3V0F8; hsa:5777; P29350; Q969V8; Q9UK67" "Prolactin signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; IL-3 signaling pathway; Kit receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Cancer immunotherapy by CTLA4 blockade; Modulators of TCR signaling and T cell activation; Interferon type I signaling pathways" "Neutrophil degranulation; CD22 mediated BCR regulation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; PD-1 signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signal regulatory protein family interactions; Interleukin receptor SHC signaling; GPVI-mediated activation cascade; Signaling by ALK; Regulation of KIT signaling; Growth hormone receptor signaling; Regulation of IFNG signaling; Regulation of IFNA/IFNB signaling; Interleukin-37 signaling; Platelet sensitization by LDL; PECAM1 interactions; Nuclear events stimulated by ALK signaling in cancer" "33" "0" "0.980" "1.031" "1.065" "1.143" "1.169" "1.180" "0.948" "1.082" "2.080" "181.4" "177.8" "187.1" "193.2" "207.3" "212.0" "214.1" "172.0" "196.2" "377.3" "" "" "" "" "" "" "" "" "" "" "96.1" "98.6" "107.1" "89.0" "112.2" "117.9" "126.0" "93.9" "110.1" "377.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3251475669442544967" "False" "High" "IsMasterProtein" "Q9P270" "SLAIN motif-containing protein 2 OS=Homo sapiens OX=9606 GN=SLAIN2 PE=1 SV=2" "0.000" "False" "11.390" "6" "3" "3" "3" "581" "62.5" "9.45" "8.83" "3" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "Pf15301" "57606" "ENSG00000109171" "SLAIN2" "A8K4P1; hsa:57606; Q8N5R3; Q9P270" "" "" "0" "0" "1.070" "1.010" "0.997" "1.020" "0.928" "0.908" "0.796" "0.945" "0.774" "149.5" "159.9" "151.0" "149.1" "152.5" "138.7" "135.8" "119.1" "141.3" "115.8" "" "" "" "" "" "" "" "" "" "" "79.2" "88.7" "86.4" "68.6" "82.5" "77.2" "79.9" "65.0" "79.3" "115.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8991505405555366750" "False" "High" "IsMasterProtein" "Q8TED0" "U3 small nucleolar RNA-associated protein 15 homolog OS=Homo sapiens OX=9606 GN=UTP15 PE=1 SV=3" "0.000" "False" "11.356" "7" "4" "4" "4" "518" "58.4" "9.11" "11.23" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus;other cell component" "" "Pf00400, Pf09384" "84135" "ENSG00000164338" "UTP15" "B4DU75; B4DXK8; hsa:84135; Q6IA60; Q8TED0; Q96E08; Q9H9F8" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.147" "0.949" "1.103" "0.932" "0.941" "1.148" "1.067" "1.176" "0.350" "80.4" "92.2" "76.3" "88.7" "75.0" "75.7" "92.3" "85.8" "94.6" "28.1" "" "" "" "" "" "" "" "" "" "" "42.6" "51.1" "43.7" "40.8" "40.6" "42.1" "54.3" "46.8" "53.1" "28.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4219783111601557579" "False" "High" "IsMasterProtein" "Q13216" "DNA excision repair protein ERCC-8 OS=Homo sapiens OX=9606 GN=ERCC8 PE=1 SV=1" "0.000" "False" "11.343" "7" "2" "2" "2" "396" "44.0" "6.35" "7.85" "2" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400" "1161" "ENSG00000049167" "ERCC8" "B2RB64; hsa:1161; Q13216; Q6FHX5; Q96GB9" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; 10q11.21q11.23 copy number variation syndrome" "Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Neddylation; Formation of TC-NER Pre-Incision Complex" "9" "0" "1.104" "1.005" "1.056" "1.056" "0.957" "1.264" "1.005" "0.922" "1.537" "69.0" "76.2" "69.4" "72.9" "72.9" "66.1" "87.3" "69.4" "63.6" "106.1" "" "" "" "" "" "" "" "" "" "" "36.6" "42.2" "39.7" "33.6" "39.4" "36.8" "51.4" "37.9" "35.7" "106.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2002509444900540538" "False" "High" "IsMasterProtein" "Q9BTY2" "Plasma alpha-L-fucosidase OS=Homo sapiens OX=9606 GN=FUCA2 PE=1 SV=2" "0.000" "False" "11.343" "7" "4" "4" "4" "467" "54.0" "6.25" "10.77" "4" "other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf01120, Pf16757" "2519" "ENSG00000001036" "FUCA2" "E9PEB6; hsa:2519; Q7Z6V1; Q7Z6Y2; Q8NBK4; Q9BTY2" "" "Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "3" "0" "1.042" "1.064" "1.028" "1.144" "1.032" "0.972" "0.989" "1.059" "0.847" "184.4" "192.2" "196.1" "189.6" "211.0" "190.2" "179.2" "182.3" "195.3" "156.2" "" "" "" "" "" "" "" "" "" "" "97.7" "106.6" "112.3" "87.3" "114.1" "105.8" "105.5" "99.5" "109.5" "156.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4819630258189506626" "False" "High" "IsMasterProtein" "P02792" "Ferritin light chain OS=Homo sapiens OX=9606 GN=FTL PE=1 SV=2" "0.000" "False" "11.333" "23" "4" "7" "4" "175" "20.0" "5.78" "14.46" "4" "transport;other biological processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00210" "2512" "ENSG00000087086" "FTL" "B2R4B9; hsa:2512; P02792; Q6IBT7; Q7Z2W1; Q86WI9; Q8WU07; Q96AU9; Q96CU0; Q9BTZ8" "Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Iron metabolism disorders" "Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Iron uptake and transport; Scavenging by Class A Receptors" "9" "0" "1.147" "1.234" "0.974" "0.921" "0.902" "1.048" "0.850" "1.074" "0.591" "636.4" "730.0" "785.3" "619.6" "586.2" "573.7" "667.3" "540.7" "683.3" "376.0" "" "" "" "" "" "" "" "" "" "" "337.0" "404.7" "449.8" "285.4" "317.2" "319.1" "392.7" "295.2" "383.3" "376.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2583602978446666213" "False" "High" "IsMasterProtein" "O15514" "DNA-directed RNA polymerase II subunit RPB4 OS=Homo sapiens OX=9606 GN=POLR2D PE=1 SV=1" "0.000" "False" "11.321" "22" "3" "4" "3" "142" "16.3" "4.79" "11.83" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf03874" "5433" "ENSG00000144231" "POLR2D" "hsa:5433; O15514; Q52LT4" "Pyrimidine metabolism" "Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "42" "0" "1.130" "1.126" "1.272" "1.145" "1.039" "1.100" "1.202" "1.324" "0.840" "184.2" "208.2" "207.4" "234.3" "211.0" "191.4" "202.6" "221.4" "243.8" "154.8" "" "" "" "" "" "" "" "" "" "" "97.5" "115.4" "118.8" "107.9" "114.2" "106.5" "119.2" "120.9" "136.8" "154.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "652466818170242457" "False" "High" "IsMasterProtein" "Q9H993" "Damage-control phosphatase ARMT1 OS=Homo sapiens OX=9606 GN=ARMT1 PE=1 SV=1" "0.000" "False" "11.315" "8" "4" "4" "4" "441" "51.1" "5.76" "11.09" "4" "other metabolic processes;stress response" "" "other molecular function" "Pf01937" "79624" "ENSG00000146476" "ARMT1" "hsa:79624; Q96FC6; Q9H993; Q9UFY5" "" "" "0" "0" "0.677" "0.799" "0.764" "1.140" "1.029" "0.790" "0.288" "0.954" "8.735" "36.9" "25.0" "29.5" "28.2" "42.0" "37.9" "29.1" "10.6" "35.2" "322.1" "" "" "" "" "" "" "" "" "" "" "19.5" "13.8" "16.9" "13.0" "22.7" "21.1" "17.2" "5.8" "19.7" "322.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8487408262660345487" "False" "High" "IsMasterProtein" "P11388" "DNA topoisomerase 2-alpha OS=Homo sapiens OX=9606 GN=TOP2A PE=1 SV=3" "0.000" "False" "11.305" "2" "4" "5" "2" "1531" "174.3" "8.72" "9.07" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00204, Pf00521, Pf01751, Pf02518, Pf08070, Pf16898" "7153" "ENSG00000131747" "TOP2A" "B2RTS1; hsa:7153; P11388; Q71UN1; Q71UQ5; Q9HB24; Q9HB25; Q9HB26; Q9UP44; Q9UQP9" "Gastric cancer network 1; Gastric cancer network 2; Retinoblastoma gene in cancer" "SUMOylation of DNA replication proteins; Transcription of E2F targets under negative control by DREAM complex" "5" "0" "1.132" "1.074" "1.439" "1.175" "1.089" "0.914" "0.734" "0.815" "4.405" "57.4" "64.9" "61.6" "82.6" "67.5" "62.5" "52.5" "42.1" "46.8" "252.8" "" "" "" "" "" "" "" "" "" "" "30.4" "36.0" "35.3" "38.0" "36.5" "34.8" "30.9" "23.0" "26.3" "252.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9023390433505774979" "False" "High" "IsMasterProtein" "P53597" "Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLG1 PE=1 SV=4" "0.000" "False" "11.291" "7" "2" "4" "2" "346" "36.2" "8.79" "9.50" "2" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00549, Pf02629" "8802" "ENSG00000163541" "SUCLG1" "hsa:8802; P53597; Q9BWB0; Q9UNP6" "Amino acid metabolism; TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle)" "3" "0" "0.963" "1.049" "0.938" "1.048" "1.020" "0.879" "0.891" "0.906" "0.748" "547.2" "526.8" "574.0" "513.3" "573.3" "558.3" "480.9" "487.5" "495.7" "409.3" "" "" "" "" "" "" "" "" "" "" "289.8" "292.1" "328.7" "236.4" "310.2" "310.5" "283.0" "266.1" "278.1" "409.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3045251361027418727" "False" "High" "IsMasterProtein" "O43237" "Cytoplasmic dynein 1 light intermediate chain 2 OS=Homo sapiens OX=9606 GN=DYNC1LI2 PE=1 SV=1" "0.000" "False" "11.274" "5" "2" "2" "2" "492" "54.1" "6.38" "6.62" "2" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05783" "1783" "ENSG00000135720" "DYNC1LI2" "A8K6V1; B4DZP4; hsa:1783; O43237; Q8TAT3" "Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption" "HCMV Early Events; COPI-mediated anterograde transport; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "14" "0" "0.994" "1.034" "1.098" "1.097" "0.962" "0.805" "0.804" "0.855" "0.852" "151.3" "150.4" "156.4" "166.2" "166.0" "145.6" "121.9" "121.6" "129.4" "128.8" "" "" "" "" "" "" "" "" "" "" "80.1" "83.4" "89.6" "76.5" "89.8" "81.0" "71.7" "66.4" "72.6" "128.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7820543804174258540" "False" "High" "IsMasterProtein" "P00374" "Dihydrofolate reductase OS=Homo sapiens OX=9606 GN=DHFR PE=1 SV=2" "0.000" "False" "11.246" "27" "5" "5" "5" "187" "21.4" "7.42" "13.37" "5" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00186" "1719" "ENSG00000228716" "DHFR" "B4DDD2; hsa:1719; P00374; Q14130; Q6IRW8" "Fluoropyrimidine activity; Folate metabolism; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration, one-carbon metabolism and related pathways; Ethanol effects on histone modifications" "G1/S-Specific Transcription; Metabolism of folate and pterines; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "9" "0" "1.053" "0.994" "1.131" "1.091" "1.046" "0.998" "0.441" "0.937" "6.156" "125.1" "131.7" "124.4" "141.4" "136.5" "130.8" "124.8" "55.2" "117.2" "769.9" "" "" "" "" "" "" "" "" "" "" "66.2" "73.0" "71.2" "65.1" "73.8" "72.8" "73.4" "30.1" "65.8" "769.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1508959840554036408" "False" "High" "IsMasterProtein" "Q969V6" "Myocardin-related transcription factor A OS=Homo sapiens OX=9606 GN=MRTFA PE=1 SV=1" "0.000" "False" "11.244" "4" "4" "4" "3" "931" "98.9" "5.86" "11.60" "4" "cell organization and biogenesis;stress response;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02037, Pf02755" "57591" "ENSG00000196588" "MRTFA" "hsa:57591; Q8TCL1; Q969V6; Q96SC5; Q96SC6; Q9P2B0" "" "RHO GTPases Activate Formins; SUMOylation of transcription cofactors" "2" "1" "0.970" "1.016" "1.161" "1.022" "0.943" "1.144" "1.096" "1.009" "0.861" "236.4" "229.3" "240.3" "274.4" "241.7" "223.0" "270.4" "259.1" "238.5" "203.5" "" "" "" "" "" "" "" "" "" "" "125.2" "127.1" "137.6" "126.3" "130.8" "124.0" "159.2" "141.4" "133.8" "203.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3676501743634657271" "False" "High" "IsMasterProtein" "P40855" "Peroxisomal biogenesis factor 19 OS=Homo sapiens OX=9606 GN=PEX19 PE=1 SV=1" "0.000" "False" "11.234" "14" "4" "5" "4" "299" "32.8" "4.34" "13.02" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04614" "5824" "ENSG00000162735" "PEX19" "D3DVE7; E9PPB4; G3V3G9; hsa:5824; P40855; Q5QNY4; Q8NI97" "TAR syndrome" "Class I peroxisomal membrane protein import; ABC transporters in lipid homeostasis" "3" "0" "1.019" "1.010" "0.996" "0.943" "0.980" "1.251" "1.112" "1.176" "0.669" "238.0" "242.6" "240.4" "237.0" "224.4" "233.2" "297.8" "264.7" "279.9" "159.3" "" "" "" "" "" "" "" "" "" "" "126.0" "134.5" "137.7" "109.1" "121.4" "129.7" "175.3" "144.5" "157.0" "159.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "51923672491572090" "False" "High" "IsMasterProtein" "Q4J6C6" "Prolyl endopeptidase-like OS=Homo sapiens OX=9606 GN=PREPL PE=1 SV=1" "0.000" "False" "11.225" "4" "3" "3" "3" "727" "83.9" "6.38" "8.96" "3" "protein metabolism;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus" "other molecular function" "Pf00326, Pf02897" "9581" "ENSG00000138078" "PREPL" "A7E2X6; D6W5A3; hsa:9581; O43163; Q4J6C3; Q4J6C4; Q4J6C6; Q4ZG39; Q6ZMW7; Q96DW7" "Primary ovarian insufficiency" "" "1" "0" "1.027" "0.883" "0.858" "0.952" "0.961" "0.871" "0.822" "0.876" "0.716" "459.8" "472.3" "406.2" "394.4" "437.6" "442.0" "400.7" "378.1" "402.8" "329.0" "" "" "" "" "" "" "" "" "" "" "243.5" "261.8" "232.6" "181.6" "236.8" "245.9" "235.8" "206.4" "225.9" "329.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4235464357787345308" "False" "High" "IsMasterProtein" "Q15370" "Elongin-B OS=Homo sapiens OX=9606 GN=ELOB PE=1 SV=1" "0.000" "False" "11.222" "20" "3" "4" "3" "118" "13.1" "4.88" "14.58" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00240" "6923" "ENSG00000103363" "ELOB" "B7WPD3; hsa:6923; Q15370" "Dual hijack model of Vif in HIV infection; Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2; Modulators of TCR signaling and T cell activation" "Regulation of expression of SLITs and ROBOs; Inactivation of CSF3 (G-CSF) signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Neddylation; Evasion by RSV of host interferon responses; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "22" "0" "0.987" "1.052" "0.868" "0.891" "0.967" "1.055" "1.142" "1.017" "0.812" "926.9" "915.1" "975.0" "804.3" "825.9" "896.7" "977.5" "1058.4" "942.3" "752.7" "" "" "" "" "" "" "" "" "" "" "490.8" "507.3" "558.4" "370.4" "446.9" "498.8" "575.3" "577.8" "528.6" "752.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-536665306058471520" "False" "High" "IsMasterProtein" "Q07020" "Large ribosomal subunit protein eL18 OS=Homo sapiens OX=9606 GN=RPL18 PE=1 SV=2" "0.000" "False" "11.215" "7" "1" "2" "1" "188" "21.6" "11.72" "7.45" "1" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf17135" "6141" "ENSG00000063177" "RPL18" "F8VWC5; hsa:6141; Q07020; Q8WTZ6" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Peptide chain elongation; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.918" "1.075" "1.342" "1.041" "1.140" "1.212" "1.029" "0.952" "0.761" "103.5" "95.0" "111.3" "138.9" "107.8" "118.0" "125.5" "106.5" "98.5" "78.8" "" "" "" "" "" "" "" "" "" "" "54.8" "52.7" "63.7" "63.9" "58.3" "65.6" "73.9" "58.1" "55.3" "78.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5301300435928167882" "False" "High" "IsMasterProtein" "P47755" "F-actin-capping protein subunit alpha-2 OS=Homo sapiens OX=9606 GN=CAPZA2 PE=1 SV=3" "0.000" "False" "11.214" "12" "3" "3" "2" "286" "32.9" "5.85" "8.79" "3" "cell organization and biogenesis" "non-structural extracellular;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01267" "830" "ENSG00000198898" "CAPZA2" "B4DG50; hsa:830; P47755" "" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Sensory processing of sound by inner hair cells of the cochlea; Factors involved in megakaryocyte development and platelet production; Advanced glycosylation endproduct receptor signaling" "7" "0" "1.046" "0.988" "1.019" "1.112" "1.096" "1.118" "1.142" "1.076" "0.628" "237.1" "248.1" "234.1" "241.6" "263.7" "259.9" "265.2" "270.7" "255.1" "149.0" "" "" "" "" "" "" "" "" "" "" "125.5" "137.6" "134.1" "111.3" "142.7" "144.6" "156.1" "147.8" "143.1" "149.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6910081975799465505" "False" "High" "IsMasterProtein" "O15042" "U2 snRNP-associated SURP motif-containing protein OS=Homo sapiens OX=9606 GN=U2SURP PE=1 SV=2" "0.000" "False" "11.204" "3" "4" "6" "4" "1029" "118.2" "8.47" "15.49" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00076, Pf01805, Pf04818, Pf08312" "23350" "ENSG00000163714" "U2SURP" "A0PJ60; hsa:23350; O15042; Q0D2M1; Q2NKQ7; Q9BR70" "" "mRNA Splicing - Major Pathway" "1" "0" "0.813" "0.874" "1.417" "1.398" "1.149" "2.088" "2.197" "2.492" "0.826" "474.9" "386.2" "415.0" "673.0" "663.9" "545.9" "991.7" "1043.2" "1183.7" "392.1" "" "" "" "" "" "" "" "" "" "" "251.5" "214.1" "237.6" "309.9" "359.2" "303.6" "583.7" "569.4" "664.0" "392.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3343567279109484109" "False" "High" "IsMasterProtein" "P61326" "Protein mago nashi homolog OS=Homo sapiens OX=9606 GN=MAGOH PE=1 SV=1" "0.000" "False" "11.200" "14" "2" "4" "2" "146" "17.2" "6.11" "12.25" "2" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus" "" "Pf02792" "4116" "ENSG00000162385" "MAGOH" "B1ARP8; B2R5A2; hsa:4116; O35169; P50606; P61326; Q5SW69" "TAR syndrome" "mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9194827022255966282" "False" "High" "IsMasterProtein" "Q9C0J8" "pre-mRNA 3' end processing protein WDR33 OS=Homo sapiens OX=9606 GN=WDR33 PE=1 SV=2" "0.000" "False" "11.188" "4" "4" "4" "4" "1336" "145.8" "9.17" "5.80" "4" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf00400, Pf01391" "55339" "ENSG00000136709" "WDR33" "hsa:55339; Q05DP8; Q53FG9; Q587J1; Q69YF7; Q6NUQ0; Q9C0J8; Q9NUL1" "" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Transport of Mature mRNA Derived from an Intronless Transcript" "5" "0" "1.127" "1.129" "1.479" "1.456" "1.196" "2.023" "2.116" "1.545" "1.008" "107.2" "120.8" "120.9" "158.4" "156.0" "128.2" "216.8" "226.8" "165.6" "108.0" "" "" "" "" "" "" "" "" "" "" "56.7" "67.0" "69.3" "73.0" "84.4" "71.3" "127.6" "123.8" "92.9" "108.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8764284085983728716" "False" "High" "IsMasterProtein" "P18583" "Protein SON OS=Homo sapiens OX=9606 GN=SON PE=1 SV=4" "0.000" "False" "11.164" "1" "2" "3" "2" "2426" "263.7" "5.64" "7.76" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf01585, Pf14709, Pf17069" "6651" "ENSG00000159140" "SON" "D3DSF5; D3DSF6; E7ETE8; E7EU67; E7EVW3; E9PFQ2; hsa:6651; O14487; O95981; P18583; Q14120; Q6PKE0; Q9H7B1; Q9P070; Q9P072; Q9UKP9; Q9UPY0" "" "" "0" "0" "1.037" "1.071" "1.373" "1.272" "1.176" "1.973" "2.036" "2.022" "2.085" "126.2" "130.9" "135.2" "173.3" "160.6" "148.5" "249.0" "257.0" "255.2" "263.2" "" "" "" "" "" "" "" "" "" "" "66.8" "72.6" "77.4" "79.8" "86.9" "82.6" "146.6" "140.3" "143.2" "263.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3981569091438122921" "False" "High" "IsMasterProtein" "Q8N4P3" "Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 OS=Homo sapiens OX=9606 GN=HDDC3 PE=1 SV=3" "0.000" "False" "11.161" "17" "3" "4" "3" "179" "20.3" "6.74" "9.50" "3" "" "" "other molecular function" "Pf13328" "374659" "ENSG00000184508" "HDDC3" "hsa:374659; Q8N4P3" "" "" "0" "0" "0.876" "1.106" "0.888" "0.921" "1.194" "0.969" "1.154" "1.083" "0.689" "206.3" "180.7" "228.3" "183.1" "190.0" "246.3" "199.9" "238.2" "223.3" "142.1" "" "" "" "" "" "" "" "" "" "" "109.2" "100.2" "130.7" "84.3" "102.8" "137.0" "117.7" "130.0" "125.3" "142.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1761615694951134021" "False" "High" "IsMasterProtein" "P62888" "Large ribosomal subunit protein eL30 OS=Homo sapiens OX=9606 GN=RPL30 PE=1 SV=2" "0.000" "False" "11.155" "29" "3" "6" "3" "115" "12.8" "9.63" "15.89" "3" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01248" "6156" "ENSG00000156482" "RPL30" "B2R591; hsa:6156; P04645; P62888; Q502Z6" "Selenium metabolism and selenoproteins; Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "1.145" "1.054" "1.316" "1.286" "1.294" "1.304" "1.432" "1.357" "0.642" "270.7" "309.9" "285.4" "356.2" "348.1" "350.4" "353.0" "387.7" "367.2" "173.8" "" "" "" "" "" "" "" "" "" "" "143.3" "171.8" "163.5" "164.0" "188.4" "194.9" "207.8" "211.7" "206.0" "173.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2806048333038512589" "False" "High" "IsMasterProtein" "Q96FQ6" "Protein S100-A16 OS=Homo sapiens OX=9606 GN=S100A16 PE=1 SV=1" "0.000" "False" "11.145" "34" "3" "3" "3" "103" "11.8" "6.79" "8.41" "3" "other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf01023" "140576" "ENSG00000188643" "S100A16" "A8K439; D3DV52; hsa:140576; Q5RHS6; Q96FQ6" "" "" "0" "0" "1.004" "1.027" "1.069" "1.177" "1.067" "0.972" "0.999" "1.074" "0.722" "85.9" "86.2" "88.2" "91.8" "101.1" "91.7" "83.5" "85.8" "92.2" "62.0" "" "" "" "" "" "" "" "" "" "" "45.5" "47.8" "50.5" "42.3" "54.7" "51.0" "49.1" "46.8" "51.7" "62.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2326963864063357056" "False" "High" "IsMasterProtein" "O95202" "Mitochondrial proton/calcium exchanger protein OS=Homo sapiens OX=9606 GN=LETM1 PE=1 SV=1" "0.000" "False" "11.143" "3" "2" "4" "2" "739" "83.3" "6.70" "10.50" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;translation activity;other molecular function" "Pf07766" "3954" "ENSG00000168924" "LETM1" "B4DED2; hsa:3954; O95202; Q9UF65" "4p16.3 copy number variation" "RHOG GTPase cycle; Mitochondrial calcium ion transport" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4839945324263831738" "False" "High" "IsMasterProtein" "Q9NTX5" "Ethylmalonyl-CoA decarboxylase OS=Homo sapiens OX=9606 GN=ECHDC1 PE=1 SV=2" "0.000" "False" "11.140" "11" "4" "5" "4" "307" "33.7" "8.21" "13.55" "4" "other metabolic processes" "cytosol" "other molecular function" "Pf00378" "55862" "ENSG00000093144" "ECHDC1" "A6NFJ5; B7Z8S0; E9PEN7; E9PR31; F8W851; hsa:55862; Q5TEF6; Q5TEF7; Q5TEG0; Q5TEG4; Q9NTX5; Q9NZ30; V9HW18" "Fatty acid biosynthesis" "" "1" "0" "0.919" "0.923" "0.998" "0.948" "1.033" "1.018" "0.948" "0.956" "0.481" "238.7" "219.2" "220.2" "238.2" "226.2" "246.6" "243.1" "226.2" "228.3" "114.8" "" "" "" "" "" "" "" "" "" "" "126.4" "121.6" "126.1" "109.7" "122.4" "137.2" "143.1" "123.5" "128.1" "114.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6104257487773187704" "False" "High" "IsMasterProtein" "Q0PNE2" "Elongator complex protein 6 OS=Homo sapiens OX=9606 GN=ELP6 PE=1 SV=1" "0.000" "False" "11.138" "12" "4" "5" "4" "266" "29.8" "6.84" "9.99" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf09807" "54859" "ENSG00000163832" "ELP6" "hsa:54859; Q0PNE2; Q9BW57; Q9NXJ3" "" "HATs acetylate histones" "1" "0" "0.848" "0.889" "0.881" "0.961" "0.829" "0.849" "0.865" "0.977" "0.728" "168.1" "142.5" "149.4" "148.1" "161.6" "139.4" "142.6" "145.3" "164.2" "122.3" "" "" "" "" "" "" "" "" "" "" "89.0" "79.0" "85.6" "68.2" "87.4" "77.5" "83.9" "79.3" "92.1" "122.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6207742459099857160" "False" "High" "IsMasterProtein" "Q9UJ41" "Rab5 GDP/GTP exchange factor OS=Homo sapiens OX=9606 GN=RABGEF1 PE=1 SV=3" "0.000" "False" "11.132" "8" "4" "4" "4" "491" "56.9" "7.02" "10.39" "4" "transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01754, Pf02204, Pf18151" "27342" "ENSG00000154710" "RABGEF1" "B4DZM7; hsa:27342; Q3HKR2; Q3HKR3; Q53FG0; Q9UJ41" "16p11.2 distal deletion syndrome" "RAB GEFs exchange GTP for GDP on RABs; TBC/RABGAPs" "3" "0" "1.058" "1.060" "1.076" "1.187" "1.129" "1.170" "1.108" "1.123" "1.373" "389.8" "412.6" "413.1" "419.5" "462.9" "440.0" "456.0" "432.0" "437.8" "535.4" "" "" "" "" "" "" "" "" "" "" "206.4" "228.8" "236.6" "193.2" "250.4" "244.8" "268.4" "235.8" "245.6" "535.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5729262198654758902" "False" "High" "IsMasterProtein" "O43396" "Thioredoxin-like protein 1 OS=Homo sapiens OX=9606 GN=TXNL1 PE=1 SV=3" "0.000" "False" "11.129" "10" "3" "4" "3" "289" "32.2" "4.96" "11.07" "3" "" "cytosol;nucleus;other cell component" "other molecular function" "Pf00085, Pf06201" "9352" "ENSG00000091164" "TXNL1" "hsa:9352; O43396" "" "RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "7" "0" "0.881" "0.886" "0.926" "0.981" "0.985" "0.889" "0.610" "0.888" "3.222" "180.9" "159.3" "160.3" "167.6" "177.6" "178.2" "160.8" "110.4" "160.7" "583.0" "" "" "" "" "" "" "" "" "" "" "95.8" "88.3" "91.8" "77.2" "96.1" "99.1" "94.6" "60.3" "90.2" "583.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3545967028758689053" "False" "High" "IsMasterProtein" "P36543" "V-type proton ATPase subunit E 1 OS=Homo sapiens OX=9606 GN=ATP6V1E1 PE=1 SV=1" "0.000" "False" "11.124" "11" "3" "5" "3" "226" "26.1" "8.00" "13.62" "3" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf01991" "529" "ENSG00000131100" "ATP6V1E1" "A8MUE4; A8MUN4; hsa:529; P36543" "VEGFA-VEGFR2 signaling; Proximal tubule transport" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "7" "0" "0.977" "0.913" "1.074" "1.062" "1.040" "0.961" "1.153" "1.069" "0.819" "70.1" "68.5" "64.0" "75.3" "74.4" "72.9" "67.3" "80.8" "74.9" "57.4" "" "" "" "" "" "" "" "" "" "" "37.1" "38.0" "36.6" "34.7" "40.3" "40.5" "39.6" "44.1" "42.0" "57.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-474422990152712875" "False" "High" "IsMasterProtein" "P61923" "Coatomer subunit zeta-1 OS=Homo sapiens OX=9606 GN=COPZ1 PE=1 SV=1" "0.000" "False" "11.122" "12" "2" "3" "2" "177" "20.2" "4.81" "9.81" "2" "transport" "other membranes;cytosol;ER/Golgi" "" "Pf01217" "22818" "ENSG00000111481" "COPZ1" "B4DDX8; B4DHZ0; F8VS17; F8VWL5; hsa:22818; P61923; Q549N6; Q9Y3C3" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "2" "0" "1.002" "1.222" "0.860" "1.078" "1.300" "0.923" "0.976" "1.132" "1.432" "254.7" "255.1" "311.1" "219.0" "274.6" "331.1" "235.0" "248.5" "288.2" "364.6" "" "" "" "" "" "" "" "" "" "" "134.8" "141.5" "178.2" "100.8" "148.6" "184.2" "138.3" "135.6" "161.7" "364.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6755202633810832906" "False" "High" "IsMasterProtein" "Q9C0I1" "Myotubularin-related protein 12 OS=Homo sapiens OX=9606 GN=MTMR12 PE=1 SV=2" "0.000" "False" "11.117" "6" "4" "4" "4" "747" "86.1" "6.62" "7.53" "4" "" "cytosol;cytoskeleton;ER/Golgi;other cell component" "" "Pf06602, Pf12578" "54545" "ENSG00000150712" "MTMR12" "hsa:54545; Q69YJ4; Q6PFW3; Q96QU2; Q9C0I1; Q9NX27" "" "Synthesis of PIPs at the early endosome membrane" "1" "0" "1.019" "0.950" "1.015" "1.159" "1.053" "0.999" "0.974" "0.991" "0.799" "224.1" "228.4" "213.0" "227.5" "259.8" "236.0" "223.9" "218.3" "222.2" "179.2" "" "" "" "" "" "" "" "" "" "" "118.7" "126.6" "122.0" "104.8" "140.6" "131.3" "131.8" "119.2" "124.7" "179.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3242855938982215798" "False" "High" "IsMasterProtein" "Q9BQP7" "Mitochondrial genome maintenance exonuclease 1 OS=Homo sapiens OX=9606 GN=MGME1 PE=1 SV=1" "0.000" "False" "11.111" "11" "4" "5" "4" "344" "39.4" "7.68" "11.97" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "mitochondrion" "other molecular function" "Pf12705" "92667" "ENSG00000125871" "MGME1" "B2RDG5; D3DW29; hsa:92667; Q96SW3; Q9BQP7" "Primary ovarian insufficiency" "" "1" "0" "0.948" "0.964" "0.965" "0.971" "1.047" "0.995" "0.992" "1.030" "0.665" "1018.4" "965.6" "982.0" "983.1" "988.8" "1066.0" "1013.6" "1009.9" "1048.5" "677.7" "" "" "" "" "" "" "" "" "" "" "539.3" "535.3" "562.4" "452.8" "535.0" "593.0" "596.5" "551.3" "588.2" "677.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3408617602849881412" "False" "High" "IsMasterProtein" "Q9UKU7" "Isobutyryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAD8 PE=1 SV=1" "0.000" "False" "11.110" "9" "4" "4" "4" "415" "45.0" "7.85" "8.32" "4" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00441, Pf02770, Pf02771" "27034" "ENSG00000151498" "ACAD8" "B7Z5W4; hsa:27034; Q6ZWP6; Q9BUS8; Q9UKU7" "" "Mitochondrial protein degradation; Branched-chain amino acid catabolism" "2" "0" "1.010" "0.953" "1.154" "1.113" "1.010" "0.960" "0.969" "0.944" "0.573" "190.8" "192.8" "181.8" "220.2" "212.5" "192.7" "183.3" "185.0" "180.2" "109.4" "" "" "" "" "" "" "" "" "" "" "101.1" "106.9" "104.1" "101.4" "115.0" "107.2" "107.9" "101.0" "101.1" "109.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2863197479310684416" "False" "High" "IsMasterProtein" "Q96EK6" "Glucosamine 6-phosphate N-acetyltransferase OS=Homo sapiens OX=9606 GN=GNPNAT1 PE=1 SV=1" "0.000" "False" "11.100" "17" "2" "5" "2" "184" "20.7" "7.99" "8.33" "2" "other metabolic processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00583" "64841" "ENSG00000100522" "GNPNAT1" "hsa:64841; Q96EK6" "" "Synthesis of UDP-N-acetyl-glucosamine" "1" "0" "1.055" "1.068" "1.105" "1.101" "0.971" "1.115" "1.099" "1.005" "0.843" "109.6" "115.6" "117.0" "121.1" "120.6" "106.4" "122.2" "120.5" "110.2" "92.4" "" "" "" "" "" "" "" "" "" "" "58.0" "64.1" "67.0" "55.8" "65.3" "59.2" "71.9" "65.8" "61.8" "92.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2189379826665428433" "False" "High" "IsMasterProtein" "Q9UMY1" "U3 small nucleolar RNA-associated protein NOL7 OS=Homo sapiens OX=9606 GN=NOL7 PE=1 SV=2" "0.000" "False" "11.100" "11" "3" "3" "3" "257" "29.4" "9.67" "10.27" "3" "other biological processes" "mitochondrion;nucleus;other cell component" "" "Pf08157" "51406" "ENSG00000225921" "NOL7" "hsa:51406; Q5T297; Q9UMY1; Q9Y3U7" "" "" "0" "0" "1.018" "1.179" "1.075" "1.037" "0.992" "1.245" "1.480" "1.351" "0.424" "477.2" "485.9" "562.6" "513.2" "495.1" "473.4" "594.3" "706.2" "644.9" "202.4" "" "" "" "" "" "" "" "" "" "" "252.7" "269.4" "322.2" "236.3" "267.8" "263.3" "349.8" "385.5" "361.8" "202.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5568233219206595783" "False" "High" "IsMasterProtein" "Q9ULT8" "E3 ubiquitin-protein ligase HECTD1 OS=Homo sapiens OX=9606 GN=HECTD1 PE=1 SV=4" "0.000" "False" "11.093" "2" "4" "4" "4" "2610" "289.2" "5.35" "10.45" "4" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus" "other molecular function" "Pf00632, Pf06701, Pf07738, Pf12796, Pf18410" "25831" "ENSG00000092148" "HECTD1" "D3DS86; hsa:25831; Q6P445; Q86VJ1; Q96F34; Q9UFZ7; Q9ULT8" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.041" "0.989" "1.149" "1.132" "1.036" "1.291" "1.292" "1.245" "2.283" "209.1" "217.8" "206.8" "240.2" "236.7" "216.6" "270.1" "270.2" "260.5" "477.5" "" "" "" "" "" "" "" "" "" "" "110.7" "120.7" "118.4" "110.6" "128.1" "120.5" "158.9" "147.5" "146.1" "477.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2854050072506968056" "False" "High" "IsMasterProtein" "P29372" "DNA-3-methyladenine glycosylase OS=Homo sapiens OX=9606 GN=MPG PE=1 SV=3" "0.000" "False" "11.077" "11" "3" "3" "3" "298" "32.8" "9.57" "7.95" "3" "DNA metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf02245" "4350" "ENSG00000103152" "MPG" "G5E9E2; hsa:4350; P29372; Q13770; Q15275; Q15961; Q5J9I4; Q96BZ6; Q96S33; Q9NNX5" "Base excision repair; DNA repair pathways, full network" "Recognition and association of DNA glycosylase with site containing an affected purine; Cleavage of the damaged purine; Displacement of DNA glycosylase by APEX1" "5" "0" "1.187" "0.982" "1.156" "1.161" "1.104" "1.097" "0.997" "0.914" "0.856" "286.4" "340.1" "281.2" "331.0" "332.6" "316.3" "314.0" "285.7" "261.8" "245.2" "" "" "" "" "" "" "" "" "" "" "151.7" "188.5" "161.0" "152.4" "180.0" "175.9" "184.8" "155.9" "146.9" "245.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8569062232649936506" "False" "High" "IsMasterProtein" "Q9NVH2" "Integrator complex subunit 7 OS=Homo sapiens OX=9606 GN=INTS7 PE=1 SV=1" "0.000" "False" "11.076" "3" "2" "2" "2" "962" "106.8" "8.02" "6.22" "2" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "" "" "25896" "ENSG00000143493" "INTS7" "B4DLZ6; B7WNP6; B7WPB6; hsa:25896; Q8N4K7; Q8WUH5; Q9H9V3; Q9NVH2; Q9NVU5; Q9UFC6; Q9UFM3" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "1.157" "1.246" "1.337" "1.169" "1.062" "1.368" "1.156" "1.334" "2.040" "59.6" "69.0" "74.3" "79.7" "69.7" "63.3" "81.6" "68.9" "79.5" "121.6" "" "" "" "" "" "" "" "" "" "" "31.6" "38.3" "42.5" "36.7" "37.7" "35.2" "48.0" "37.6" "44.6" "121.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2588985702309620212" "False" "High" "IsMasterProtein" "O75792" "Ribonuclease H2 subunit A OS=Homo sapiens OX=9606 GN=RNASEH2A PE=1 SV=2" "0.000" "False" "11.074" "11" "3" "4" "3" "299" "33.4" "5.25" "10.51" "3" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01351" "10535" "ENSG00000104889" "RNASEH2A" "B2RCY1; hsa:10535; O75792; Q96F11" "" "" "0" "0" "1.108" "0.987" "1.022" "1.028" "0.815" "1.039" "0.795" "0.930" "2.457" "141.1" "156.4" "139.3" "144.2" "145.1" "115.0" "146.7" "112.2" "131.3" "346.7" "" "" "" "" "" "" "" "" "" "" "74.7" "86.7" "79.8" "66.4" "78.5" "64.0" "86.3" "61.3" "73.6" "346.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3899808669823360054" "False" "High" "IsMasterProtein" "Q9Y2U8" "Inner nuclear membrane protein Man1 OS=Homo sapiens OX=9606 GN=LEMD3 PE=1 SV=2" "0.000" "False" "11.074" "3" "2" "2" "2" "911" "99.9" "7.55" "7.33" "2" "other biological processes" "other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf03020, Pf09402" "23592" "ENSG00000174106" "LEMD3" "hsa:23592; Q9NT47; Q9NYA5; Q9Y2U8" "Envelope proteins and their potential roles in EDMD physiopathology" "RND2 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina" "12" "0" "1.045" "1.035" "1.215" "1.082" "1.092" "1.299" "1.365" "1.176" "0.883" "234.8" "245.4" "243.1" "285.4" "254.1" "256.3" "305.1" "320.5" "276.0" "207.2" "" "" "" "" "" "" "" "" "" "" "124.3" "136.1" "139.2" "131.4" "137.5" "142.6" "179.6" "174.9" "154.9" "207.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-493599392499449744" "False" "High" "IsMasterProtein" "P53990" "IST1 homolog OS=Homo sapiens OX=9606 GN=IST1 PE=1 SV=1" "0.000" "False" "11.067" "9" "3" "3" "3" "364" "39.7" "5.35" "10.07" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03398" "9798" "ENSG00000182149" "IST1" "A8KAH5; hsa:9798; J3QLU7; P53990; Q3SYM4; Q9BQ81; Q9BWN2" "" "Neutrophil degranulation; Sealing of the nuclear envelope (NE) by ESCRT-III" "2" "0" "1.048" "1.001" "1.020" "1.047" "1.029" "1.029" "1.057" "0.964" "1.931" "552.7" "579.4" "553.1" "564.0" "578.6" "569.0" "568.5" "584.4" "532.8" "1067.5" "" "" "" "" "" "" "" "" "" "" "292.7" "321.3" "316.8" "259.7" "313.0" "316.5" "334.6" "319.0" "298.9" "1067.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5775237487534858758" "False" "High" "IsMasterProtein" "P62750" "Large ribosomal subunit protein uL23 OS=Homo sapiens OX=9606 GN=RPL23A PE=1 SV=1" "0.000" "False" "11.055" "18" "3" "5" "3" "156" "17.7" "10.45" "13.43" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00276, Pf03939" "6147" "ENSG00000198242" "RPL23A" "B2R5B2; hsa:6147; P29316; P39024; P62750; Q92774" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.025" "1.138" "1.182" "1.103" "1.188" "1.139" "1.308" "1.401" "1.501" "294.0" "301.2" "334.7" "347.5" "324.2" "349.3" "334.8" "384.7" "412.0" "441.4" "" "" "" "" "" "" "" "" "" "" "155.7" "167.0" "191.7" "160.0" "175.4" "194.3" "197.0" "210.0" "231.1" "441.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4871299150167349072" "False" "High" "IsMasterProtein" "Q8TF68" "Zinc finger protein 384 OS=Homo sapiens OX=9606 GN=ZNF384 PE=1 SV=2" "0.000" "False" "11.054" "9" "3" "4" "3" "577" "63.2" "8.95" "5.13" "3" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13912" "171017" "ENSG00000126746" "ZNF384" "hsa:171017; O15407; Q7Z722; Q8N938; Q8TF68" "" "" "0" "0" "1.087" "0.989" "0.897" "0.997" "0.923" "0.943" "0.887" "0.917" "0.571" "300.2" "326.4" "297.0" "269.4" "299.2" "277.0" "283.2" "266.3" "275.4" "171.5" "" "" "" "" "" "" "" "" "" "" "159.0" "181.0" "170.1" "124.1" "161.9" "154.1" "166.7" "145.4" "154.5" "171.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3544092344489090561" "False" "High" "IsMasterProtein" "Q8TB72" "Pumilio homolog 2 OS=Homo sapiens OX=9606 GN=PUM2 PE=1 SV=2" "0.000" "False" "11.053" "4" "5" "6" "3" "1066" "114.1" "7.08" "15.58" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00806" "23369" "ENSG00000055917" "PUM2" "B3KSL0; B4E2B6; D6W527; hsa:23369; O00234; Q53TV7; Q8TB72; Q8WY43; Q9HAN2" "Male infertility" "Neddylation" "2" "1" "0.947" "0.991" "0.906" "1.018" "1.056" "0.748" "0.802" "0.866" "0.952" "537.3" "509.0" "532.4" "486.6" "546.7" "567.4" "401.9" "430.7" "465.1" "511.3" "" "" "" "" "" "" "" "" "" "" "284.5" "282.2" "304.9" "224.1" "295.8" "315.6" "236.5" "235.1" "260.9" "511.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2503112779916804665" "False" "High" "IsMasterProtein" "Q8WV28" "B-cell linker protein OS=Homo sapiens OX=9606 GN=BLNK PE=1 SV=2" "0.000" "False" "11.046" "10" "5" "6" "5" "456" "50.4" "8.16" "13.45" "5" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017" "29760" "ENSG00000095585" "BLNK" "hsa:29760; O75498; O75499; Q2MD49; Q8WV28" "B cell receptor signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2" "Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Regulation of signaling by CBL" "5" "0" "0.974" "1.071" "1.081" "1.010" "0.988" "1.135" "1.150" "1.045" "0.713" "276.3" "269.2" "295.8" "298.7" "279.0" "273.1" "313.6" "317.9" "288.7" "196.9" "" "" "" "" "" "" "" "" "" "" "146.3" "149.3" "169.4" "137.6" "151.0" "151.9" "184.5" "173.5" "161.9" "196.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7253720687934924150" "False" "High" "IsMasterProtein" "P19525" "Interferon-induced, double-stranded RNA-activated protein kinase OS=Homo sapiens OX=9606 GN=EIF2AK2 PE=1 SV=2" "0.000" "False" "11.044" "4" "2" "2" "2" "551" "62.1" "8.40" "6.53" "2" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00035, Pf00069" "5610" "ENSG00000055332" "EIF2AK2" "A8K3P0; D6W584; E9PC80; hsa:5610; P19525; Q52M43; Q7Z6F6; Q9UIR4" "Translation factors; Alzheimer's disease and miRNA effects; PDGFR-beta pathway; Ebola virus infection in host; Measles virus infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; Alzheimer's disease; Roles of ceramides in development of insulin resistance; Type II interferon signaling" "ISG15 antiviral mechanism; PKR-mediated signaling; Interferon alpha/beta signaling; Evasion by RSV of host interferon responses; Inhibition of PKR; SUMOylation of immune response proteins" "16" "0" "0.874" "0.947" "0.931" "0.949" "1.018" "1.077" "0.863" "1.123" "3.723" "273.3" "238.8" "258.8" "254.3" "259.5" "278.1" "294.4" "235.8" "306.8" "1017.5" "" "" "" "" "" "" "" "" "" "" "144.7" "132.4" "148.2" "117.1" "140.4" "154.7" "173.3" "128.7" "172.1" "1017.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "117675378851989584" "False" "High" "IsMasterProtein" "P56270" "Myc-associated zinc finger protein OS=Homo sapiens OX=9606 GN=MAZ PE=1 SV=1" "0.000" "False" "11.016" "5" "4" "4" "4" "477" "48.6" "8.95" "11.84" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13894" "4150" "ENSG00000103495" "MAZ" "A8QJL9; C6G496; G5E927; H3BQD6; hsa:4150; P56270; Q15703; Q8NFN7; Q99443" "16p11.2 proximal deletion syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways" "" "2" "0" "1.020" "0.968" "1.003" "1.081" "0.999" "1.063" "1.121" "1.079" "0.665" "525.8" "536.5" "508.8" "527.5" "568.1" "525.4" "559.1" "589.3" "567.6" "349.9" "" "" "" "" "" "" "" "" "" "" "278.4" "297.5" "291.4" "242.9" "307.4" "292.3" "329.1" "321.7" "318.4" "349.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2753103137801597372" "False" "High" "IsMasterProtein" "Q99618" "Cell division cycle-associated protein 3 OS=Homo sapiens OX=9606 GN=CDCA3 PE=1 SV=1" "0.000" "False" "11.008" "19" "4" "4" "4" "268" "29.0" "6.43" "8.66" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "" "" "83461" "ENSG00000111665" "CDCA3" "A8K5V6; D3DUS6; hsa:83461; Q99618" "" "" "0" "0" "1.065" "1.005" "1.166" "1.039" "0.997" "0.933" "0.968" "1.083" "1.600" "232.8" "247.8" "234.0" "271.5" "241.9" "232.2" "217.1" "225.3" "252.0" "372.4" "" "" "" "" "" "" "" "" "" "" "123.3" "137.4" "134.0" "125.0" "130.9" "129.1" "127.8" "123.0" "141.4" "372.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5517999105151406307" "False" "High" "IsMasterProtein" "Q9NWT1" "p21-activated protein kinase-interacting protein 1 OS=Homo sapiens OX=9606 GN=PAK1IP1 PE=1 SV=2" "0.000" "False" "10.993" "8" "4" "5" "4" "392" "43.9" "8.91" "13.28" "4" "cell cycle OR cell proliferation;other biological processes" "nucleus" "" "Pf00400" "55003" "ENSG00000111845; ENSG00000285226" "PAK1IP1" "hsa:55003; Q5T4J2; Q96QJ8; Q96T87; Q9NWT1" "" "" "0" "0" "0.888" "0.850" "0.827" "0.819" "0.774" "0.793" "0.714" "0.704" "0.469" "1168.6" "1038.0" "992.7" "966.1" "956.6" "904.0" "926.4" "834.1" "822.8" "547.9" "" "" "" "" "" "" "" "" "" "" "618.8" "575.5" "568.5" "444.9" "517.5" "502.9" "545.2" "455.3" "461.6" "547.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2516739525907873838" "False" "High" "IsMasterProtein" "Q96RN5" "Mediator of RNA polymerase II transcription subunit 15 OS=Homo sapiens OX=9606 GN=MED15 PE=1 SV=2" "0.000" "False" "10.955" "5" "3" "4" "3" "788" "86.7" "9.42" "14.37" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09606, Pf21538, Pf21539" "51586" "ENSG00000099917" "MED15" "D3DX31; D3DX32; hsa:51586; O15413; Q6IC31; Q8NF16; Q96CT0; Q96IH7; Q96RN5; Q9P1T3" "Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; 22q11.2 copy number variation syndrome" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "7" "0" "0.963" "1.072" "1.266" "1.186" "1.247" "1.201" "1.042" "1.161" "1.340" "56.2" "54.1" "60.3" "71.2" "66.7" "70.1" "67.5" "58.6" "65.2" "75.3" "" "" "" "" "" "" "" "" "" "" "29.8" "30.0" "34.5" "32.8" "36.1" "39.0" "39.7" "32.0" "36.6" "75.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5768546020460865093" "False" "High" "IsMasterProtein" "O15160" "DNA-directed RNA polymerases I and III subunit RPAC1 OS=Homo sapiens OX=9606 GN=POLR1C PE=1 SV=1" "0.000" "False" "10.943" "8" "2" "2" "2" "346" "39.2" "5.50" "6.69" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01000, Pf01193" "9533" "ENSG00000171453" "POLR1C" "hsa:9533; O15160; O75395; Q5JTE3" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "15" "0" "1.068" "1.118" "0.828" "1.090" "1.054" "1.219" "1.011" "1.183" "3.188" "153.1" "163.5" "171.2" "126.9" "167.0" "161.4" "186.6" "154.9" "181.1" "488.1" "" "" "" "" "" "" "" "" "" "" "81.1" "90.6" "98.0" "58.4" "90.3" "89.8" "109.8" "84.5" "101.6" "488.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5123694492544734526" "False" "High" "IsMasterProtein" "Q99417" "c-Myc-binding protein OS=Homo sapiens OX=9606 GN=MYCBP PE=1 SV=3" "0.000" "False" "10.932" "28" "3" "4" "3" "103" "12.0" "5.91" "8.09" "3" "other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "" "26292" "ENSG00000214114" "MYCBP" "B2R4N0; hsa:26292; Q5TA64; Q96HE2; Q99417" "Pathways affected in adenoid cystic carcinoma" "" "1" "0" "1.370" "1.172" "1.133" "1.275" "1.042" "1.287" "1.315" "1.330" "1.657" "63.6" "87.2" "74.5" "72.1" "81.1" "66.3" "81.9" "83.7" "84.6" "105.4" "" "" "" "" "" "" "" "" "" "" "33.7" "48.3" "42.7" "33.2" "43.9" "36.9" "48.2" "45.7" "47.5" "105.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3461094019956647414" "False" "High" "IsMasterProtein" "Q96KQ7" "Histone-lysine N-methyltransferase EHMT2 OS=Homo sapiens OX=9606 GN=EHMT2 PE=1 SV=3" "0.000" "False" "10.926" "3" "4" "8" "4" "1210" "132.3" "5.45" "19.52" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00023, Pf00856, Pf05033, Pf21533" "10919" "ENSG00000204371; ENSG00000206376; ENSG00000227333; ENSG00000232045; ENSG00000236759; ENSG00000238134" "EHMT2" "B0UZY2; hsa:10919; Q14349; Q5JP83; Q5JQ92; Q5JQA1; Q5JQG3; Q6PK06; Q96KQ7; Q96MH5; Q96QD0; Q9UQL8; Q9Y331" "Histone modifications; Ethanol effects on histone modifications; MTHFR deficiency" "Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by E2F6; Transcriptional Regulation by VENTX; PKMTs methylate histone lysines; Regulation of TP53 Activity through Methylation; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" "10" "0" "0.987" "1.032" "1.127" "1.146" "1.091" "1.682" "1.614" "1.595" "1.589" "631.3" "623.2" "651.7" "711.3" "723.4" "688.8" "1061.7" "1019.0" "1007.0" "1003.3" "" "" "" "" "" "" "" "" "" "" "334.3" "345.5" "373.2" "327.6" "391.4" "383.2" "624.9" "556.2" "564.9" "1003.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3174171264893505362" "False" "High" "IsMasterProtein" "Q9H2J4" "Phosducin-like protein 3 OS=Homo sapiens OX=9606 GN=PDCL3 PE=1 SV=1" "0.000" "False" "10.924" "15" "3" "3" "3" "239" "27.6" "4.84" "8.37" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02114" "79031" "ENSG00000115539" "PDCL3" "B2RA00; hsa:79031; Q53S68; Q9H2J4" "" "" "0" "0" "1.016" "0.977" "1.026" "1.007" "1.057" "1.027" "1.056" "1.011" "0.628" "380.6" "386.6" "371.7" "390.4" "383.4" "402.3" "391.0" "401.8" "384.7" "239.1" "" "" "" "" "" "" "" "" "" "" "201.5" "214.3" "212.9" "179.8" "207.4" "223.8" "230.1" "219.3" "215.8" "239.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7441805136985848157" "False" "High" "IsMasterProtein" "Q8TB52" "F-box only protein 30 OS=Homo sapiens OX=9606 GN=FBXO30 PE=1 SV=3" "0.000" "False" "10.924" "3" "3" "3" "3" "745" "82.3" "5.40" "9.32" "3" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf15965, Pf15966" "84085" "ENSG00000118496" "FBXO30" "hsa:84085; Q8TB52; Q9BXZ7" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "1.140" "1.130" "1.093" "1.082" "1.056" "0.946" "0.807" "0.916" "1.424" "191.9" "218.8" "216.8" "209.6" "207.7" "202.6" "181.6" "154.9" "175.8" "273.2" "" "" "" "" "" "" "" "" "" "" "101.6" "121.3" "124.1" "96.5" "112.3" "112.7" "106.9" "84.5" "98.6" "273.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1844756928667547842" "False" "High" "IsMasterProtein" "Q9NWU1" "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial OS=Homo sapiens OX=9606 GN=OXSM PE=1 SV=1" "0.000" "False" "10.910" "5" "2" "3" "2" "459" "48.8" "7.66" "8.45" "2" "other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00109, Pf02801" "54995" "ENSG00000151093" "OXSM" "Q9NWU1" "Mitochondrial fatty acid synthesis pathway" "Mitochondrial protein degradation" "2" "0" "0.903" "0.946" "0.937" "0.927" "1.016" "0.926" "0.973" "0.965" "0.513" "538.4" "485.9" "509.4" "504.5" "498.9" "547.1" "498.6" "523.9" "519.7" "276.0" "" "" "" "" "" "" "" "" "" "" "285.1" "269.4" "291.7" "232.3" "269.9" "304.3" "293.4" "286.0" "291.5" "276.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7745810489150015985" "False" "High" "IsMasterProtein" "O95292" "Vesicle-associated membrane protein-associated protein B/C OS=Homo sapiens OX=9606 GN=VAPB PE=1 SV=3" "0.000" "False" "10.904" "8" "2" "4" "1" "243" "27.2" "7.30" "10.49" "2" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00635" "9217" "ENSG00000124164" "VAPB" "A2A2F2; hsa:9217; O95292; O95293; Q9P0H0" "Ciliary landscape" "RHOC GTPase cycle; RHOA GTPase cycle; RHOG GTPase cycle; Sphingolipid de novo biosynthesis; RAC2 GTPase cycle; RHOD GTPase cycle" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8980263924004467581" "False" "High" "IsMasterProtein" "P28340" "DNA polymerase delta catalytic subunit OS=Homo sapiens OX=9606 GN=POLD1 PE=1 SV=2" "0.000" "False" "10.855" "4" "4" "4" "4" "1107" "123.6" "7.03" "10.96" "4" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00136, Pf03104, Pf14260" "5424" "ENSG00000062822" "POLD1" "hsa:5424; P28340; Q8NER3; Q96H98" "Homologous recombination; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Progeria-associated lipodystrophy; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Gap-filling DNA repair synthesis and ligation in TC-NER; Gap-filling DNA repair synthesis and ligation in GG-NER; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Cytosolic iron-sulfur cluster assembly; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "27" "0" "0.569" "0.487" "0.557" "0.552" "0.590" "0.741" "0.533" "0.495" "2.170" "253.0" "143.8" "123.3" "140.9" "139.7" "149.2" "187.5" "134.9" "125.4" "549.0" "" "" "" "" "" "" "" "" "" "" "134.0" "79.8" "70.6" "64.9" "75.6" "83.0" "110.4" "73.6" "70.3" "549.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3138004166962983246" "False" "High" "IsMasterProtein" "Q92688" "Acidic leucine-rich nuclear phosphoprotein 32 family member B OS=Homo sapiens OX=9606 GN=ANP32B PE=1 SV=1" "0.000" "False" "10.854" "15" "4" "5" "2" "251" "28.8" "4.06" "10.53" "4" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12799" "10541" "ENSG00000136938" "ANP32B" "B2R9C7; hsa:10541; O00655; P78458; P78459; Q92688" "" "" "0" "0" "1.092" "1.245" "1.067" "1.065" "1.122" "1.613" "1.874" "1.856" "1.288" "695.8" "759.9" "865.9" "742.4" "740.8" "780.6" "1122.1" "1304.0" "1291.1" "896.4" "" "" "" "" "" "" "" "" "" "" "368.4" "421.3" "495.9" "341.9" "400.8" "434.2" "660.4" "711.8" "724.3" "896.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6116188343313863326" "False" "High" "IsMasterProtein" "Q6P1L8" "Large ribosomal subunit protein uL14m OS=Homo sapiens OX=9606 GN=MRPL14 PE=1 SV=1" "0.000" "False" "10.854" "23" "2" "3" "2" "145" "15.9" "10.24" "9.48" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00238" "64928" "ENSG00000180992" "MRPL14" "B2R575; hsa:64928; Q6P1L8; Q96Q72" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.036" "0.928" "1.327" "1.106" "0.937" "1.169" "1.007" "1.022" "0.766" "125.8" "130.3" "116.8" "166.9" "139.1" "117.9" "147.0" "126.7" "128.6" "96.3" "" "" "" "" "" "" "" "" "" "" "66.6" "72.2" "66.9" "76.9" "75.3" "65.6" "86.5" "69.1" "72.1" "96.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3301543360737881129" "False" "High" "IsMasterProtein" "Q9Y281" "Cofilin-2 OS=Homo sapiens OX=9606 GN=CFL2 PE=1 SV=1" "0.000" "False" "10.852" "11" "2" "8" "1" "166" "18.7" "7.88" "15.56" "2" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00241" "1073" "ENSG00000165410" "CFL2" "G3V5P4; hsa:1073; Q9Y281" "Leptin signaling pathway; Microtubule cytoskeleton regulation; Regulation of actin cytoskeleton; G13 signaling pathway" "" "4" "0" "0.984" "1.023" "0.984" "0.853" "0.920" "0.995" "0.993" "1.089" "0.658" "150.5" "148.1" "153.9" "148.1" "128.4" "138.5" "149.8" "149.5" "163.8" "99.0" "" "" "" "" "" "" "" "" "" "" "79.7" "82.1" "88.2" "68.2" "69.5" "77.0" "88.2" "81.6" "91.9" "99.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1388353290409054284" "False" "High" "IsMasterProtein" "Q9NNW7" "Thioredoxin reductase 2, mitochondrial OS=Homo sapiens OX=9606 GN=TXNRD2 PE=1 SV=3" "0.000" "False" "10.843" "7" "4" "6" "4" "524" "56.5" "7.50" "15.07" "4" "stress response;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf02852, Pf07992" "10587" "ENSG00000184470" "TXNRD2" "hsa:10587; O95840; Q96IJ2; Q9H2Z5; Q9NNW7; Q9NZV3; Q9NZV4; Q9P2Y0; Q9P2Y1; Q9UQU8" "Selenium micronutrient network; Selenium micronutrient network ; Selenium micronutrient network; Selenium metabolism and selenoproteins; Oxidative stress response; 22q11.2 copy number variation syndrome" "Detoxification of Reactive Oxygen Species" "7" "0" "1.046" "0.976" "1.088" "1.143" "1.051" "1.253" "1.097" "1.088" "0.898" "334.2" "349.4" "326.2" "363.7" "382.0" "351.1" "418.9" "366.7" "363.4" "300.1" "" "" "" "" "" "" "" "" "" "" "176.9" "193.7" "186.8" "167.5" "206.7" "195.3" "246.5" "200.2" "203.9" "300.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4814601069630724909" "False" "High" "IsMasterProtein" "Q15906" "Vacuolar protein sorting-associated protein 72 homolog OS=Homo sapiens OX=9606 GN=VPS72 PE=1 SV=1" "0.000" "False" "10.836" "9" "3" "4" "3" "364" "40.6" "6.48" "9.27" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05764, Pf08265" "6944" "ENSG00000163159" "VPS72" "A6NLK9; A6PW55; hsa:6944; Q15906; Q53GJ2; Q5U0R4" "" "HATs acetylate histones" "1" "0" "1.007" "0.980" "1.224" "1.017" "1.117" "1.254" "0.855" "0.891" "1.781" "77.6" "78.1" "76.1" "95.0" "78.9" "86.7" "97.2" "66.3" "69.1" "138.1" "" "" "" "" "" "" "" "" "" "" "41.1" "43.3" "43.6" "43.7" "42.7" "48.2" "57.2" "36.2" "38.8" "138.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1587907933929237870" "False" "High" "IsMasterProtein" "Q02548" "Paired box protein Pax-5 OS=Homo sapiens OX=9606 GN=PAX5 PE=1 SV=1" "0.000" "False" "10.814" "7" "2" "3" "2" "391" "42.1" "9.00" "10.34" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00292, Pf12403" "5079" "ENSG00000196092" "PAX5" "A3QVP6; A3QVP7; A3QVP8; C0KTF6; C0KTF7; C0KTF8; C0KTF9; C0KTG0; hsa:5079; O75933; Q02548; Q5SFM2; Q6S728; Q6S729; Q6S730; Q6S731; Q6S732" "Prion disease pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2; ID signaling pathway" "RUNX1 regulates transcription of genes involved in BCR signaling" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3994856410542386969" "False" "High" "IsMasterProtein" "Q9BW92" "Threonine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=TARS2 PE=1 SV=1" "0.000" "False" "10.813" "5" "4" "4" "4" "718" "81.0" "7.30" "8.23" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00587, Pf02824, Pf03129, Pf07973" "80222" "ENSG00000143374" "TARS2" "hsa:80222; Q53GW7; Q96I50; Q9BW92; Q9H9V2" "" "Mitochondrial tRNA aminoacylation" "1" "0" "1.063" "1.087" "1.171" "1.245" "1.265" "1.094" "1.072" "1.129" "1.704" "298.5" "317.4" "324.3" "349.6" "371.5" "377.5" "326.4" "320.1" "337.0" "508.6" "" "" "" "" "" "" "" "" "" "" "158.0" "175.9" "185.7" "161.0" "201.0" "210.0" "192.1" "174.7" "189.0" "508.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4679234799158284053" "False" "High" "IsMasterProtein" "Q8N954" "G patch domain-containing protein 11 OS=Homo sapiens OX=9606 GN=GPATCH11 PE=1 SV=4" "0.000" "False" "10.810" "8" "3" "3" "3" "285" "33.3" "5.86" "9.65" "3" "" "other cell component" "nucleic acid binding activity" "Pf01585, Pf13821" "253635" "" "GPATCH11" "A0A0A0MSF9; A8K0D9; B7Z2G4; B8ZZ44; hsa:253635; Q8N954" "" "" "0" "0" "1.127" "1.170" "1.089" "1.056" "1.137" "1.108" "1.207" "1.213" "0.588" "479.2" "540.1" "560.5" "521.7" "505.9" "544.8" "531.0" "578.5" "581.2" "281.9" "" "" "" "" "" "" "" "" "" "" "253.7" "299.4" "321.0" "240.3" "273.7" "303.1" "312.5" "315.8" "326.1" "281.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8981469479003528624" "False" "High" "IsMasterProtein" "Q9BZE1" "Large ribosomal subunit protein mL37 OS=Homo sapiens OX=9606 GN=MRPL37 PE=1 SV=2" "0.000" "False" "10.806" "6" "2" "3" "2" "423" "48.1" "8.59" "9.96" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf07147" "51253" "ENSG00000116221" "MRPL37" "hsa:51253; Q96Q67; Q9BWR1; Q9BZE1; Q9P0P3" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.926" "0.947" "1.094" "1.180" "0.909" "1.037" "1.227" "1.040" "0.896" "48.8" "45.1" "46.2" "53.3" "57.5" "44.3" "50.6" "59.9" "50.7" "43.7" "" "" "" "" "" "" "" "" "" "" "25.8" "25.0" "26.5" "24.6" "31.1" "24.7" "29.8" "32.7" "28.5" "43.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3253297407861631258" "False" "High" "IsMasterProtein" "O95155" "Ubiquitin conjugation factor E4 B OS=Homo sapiens OX=9606 GN=UBE4B PE=1 SV=1" "0.000" "False" "10.802" "3" "4" "5" "4" "1302" "146.1" "6.55" "13.98" "4" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04564, Pf10408" "10277" "ENSG00000130939" "UBE4B" "A8K8S9; G0ZJH6; O75169; O95155; O95338; Q5SZ12; Q5SZ16; Q96QD4; Q9BYI7" "" "" "0" "0" "1.059" "1.107" "1.041" "1.273" "1.138" "1.078" "1.063" "1.085" "2.141" "325.5" "344.8" "360.2" "338.8" "414.2" "370.6" "350.7" "345.9" "353.3" "697.1" "" "" "" "" "" "" "" "" "" "" "172.4" "191.2" "206.3" "156.0" "224.1" "206.1" "206.4" "188.8" "198.2" "697.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "636260914267966179" "False" "High" "IsMasterProtein" "Q6YP21" "Kynurenine--oxoglutarate transaminase 3 OS=Homo sapiens OX=9606 GN=KYAT3 PE=1 SV=1" "0.000" "False" "10.797" "6" "3" "4" "3" "454" "51.4" "8.19" "12.73" "3" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00155" "56267" "ENSG00000137944" "KYAT3" "B3KQ13; hsa:56267; O95335; Q5JS27; Q5T9T7; Q5T9T8; Q6AI27; Q6ICW1; Q6YP21; Q9BVY5" "Tryptophan metabolism" "Tryptophan catabolism" "2" "0" "0.880" "1.068" "0.768" "1.019" "1.064" "0.928" "0.971" "0.953" "0.600" "297.4" "261.8" "317.5" "228.4" "303.2" "316.3" "275.8" "288.7" "283.4" "178.3" "" "" "" "" "" "" "" "" "" "" "157.5" "145.1" "181.8" "105.2" "164.0" "175.9" "162.3" "157.6" "159.0" "178.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3200038646673232615" "False" "High" "IsMasterProtein" "Q9P287" "BRCA2 and CDKN1A-interacting protein OS=Homo sapiens OX=9606 GN=BCCIP PE=1 SV=1" "0.000" "False" "10.770" "10" "2" "2" "2" "314" "36.0" "4.61" "6.26" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus" "enzyme regulator activity;cytoskeletal activity" "Pf13862" "56647" "ENSG00000107949" "BCCIP" "B3KP45; hsa:56647; Q8ND15; Q96GC4; Q9P287; Q9P288" "" "" "0" "0" "1.365" "1.137" "1.474" "1.556" "1.501" "1.635" "1.155" "1.367" "1.148" "29.5" "40.3" "33.5" "43.5" "45.9" "44.3" "48.2" "34.1" "40.3" "33.9" "" "" "" "" "" "" "" "" "" "" "15.6" "22.3" "19.2" "20.0" "24.8" "24.6" "28.4" "18.6" "22.6" "33.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7463196673493200714" "False" "High" "IsMasterProtein" "P01116" "GTPase KRas OS=Homo sapiens OX=9606 GN=KRAS PE=1 SV=1" "0.000" "False" "10.763" "16" "3" "3" "1" "189" "21.6" "6.77" "7.85" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00071" "3845" "ENSG00000133703" "KRAS" "A8K8Z5; B0LPF9; hsa:3845; P01116; P01118; Q96D10" "IL-5 signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; TNF-alpha signaling pathway; Oncostatin M signaling pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; Extracellular vesicle-mediated signaling in recipient cells; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Kisspeptin/kisspeptin receptor system in the ovary; MAPK pathway in congenital thyroid cancer; Regulation of actin cytoskeleton; Alzheimer's disease; Acute myeloid leukemia; Autophagy in pancreatic ductal adenocarcinoma; JAK-STAT signaling in the regulation of beta cells; ErbB signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling" "Signaling by CSF3 (G-CSF); Signaling by CSF1 (M-CSF) in myeloid cells; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAS GAP mutants; Signaling by RAS GTPase mutants; RUNX3 regulates p14-ARF" "60" "0" "1.012" "1.091" "1.309" "1.201" "1.060" "1.410" "1.037" "1.020" "0.737" "69.8" "70.7" "76.2" "91.5" "83.9" "74.0" "98.5" "72.4" "71.2" "51.5" "" "" "" "" "" "" "" "" "" "" "37.0" "39.2" "43.6" "42.1" "45.4" "41.2" "58.0" "39.5" "40.0" "51.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6205796797264401430" "False" "High" "IsMasterProtein" "Q96DH6" "RNA-binding protein Musashi homolog 2 OS=Homo sapiens OX=9606 GN=MSI2 PE=1 SV=1" "0.000" "False" "10.753" "11" "3" "3" "3" "328" "35.2" "8.48" "8.90" "3" "developmental processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "124540" "ENSG00000153944" "MSI2" "hsa:124540; Q7Z6M7; Q8N9T4; Q96DH6" "" "RHOBTB2 GTPase cycle" "1" "0" "1.092" "1.165" "1.234" "1.124" "1.275" "1.122" "1.050" "1.078" "1.014" "90.2" "98.5" "105.0" "111.2" "101.4" "115.0" "101.2" "94.7" "97.2" "91.4" "" "" "" "" "" "" "" "" "" "" "47.7" "54.6" "60.2" "51.2" "54.8" "63.9" "59.5" "51.7" "54.5" "91.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8408211072324921186" "False" "High" "IsMasterProtein" "P78344" "Eukaryotic translation initiation factor 4 gamma 2 OS=Homo sapiens OX=9606 GN=EIF4G2 PE=1 SV=1" "0.000" "False" "10.747" "3" "3" "3" "3" "907" "102.3" "7.14" "6.58" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf02020, Pf02847, Pf02854" "1982" "ENSG00000110321" "EIF4G2" "hsa:1982; O60877; P78344; P78404; Q0VH00; Q0VH01; Q2NKW9; Q49A79; Q53EU1; Q58EZ2; Q8NI71; Q96C16" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation; Acute viral myocarditis" "ISG15 antiviral mechanism" "4" "0" "1.021" "0.929" "0.988" "0.952" "1.036" "0.973" "0.396" "0.992" "7.490" "232.4" "237.1" "215.9" "229.6" "221.3" "240.8" "226.1" "91.9" "230.5" "1740.4" "" "" "" "" "" "" "" "" "" "" "123.0" "131.5" "123.6" "105.7" "119.7" "133.9" "133.1" "50.2" "129.3" "1740.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5199956621996248182" "False" "High" "IsMasterProtein" "P18859" "ATP synthase-coupling factor 6, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PF PE=1 SV=1" "0.000" "False" "10.745" "18" "1" "1" "1" "108" "12.6" "9.52" "5.49" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf05511" "522" "ENSG00000154723" "ATP5PF" "hsa:522; J3KQ83; P18859" "Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation" "Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "5" "0" "0.841" "0.948" "0.989" "0.968" "0.926" "0.993" "0.900" "1.009" "0.538" "63.0" "53.0" "59.7" "62.3" "61.0" "58.4" "62.5" "56.7" "63.6" "33.9" "" "" "" "" "" "" "" "" "" "" "33.4" "29.4" "34.2" "28.7" "33.0" "32.5" "36.8" "30.9" "35.7" "33.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7460825629413537855" "False" "High" "IsMasterProtein" "Q9BV40" "Vesicle-associated membrane protein 8 OS=Homo sapiens OX=9606 GN=VAMP8 PE=1 SV=1" "0.000" "False" "10.743" "39" "4" "5" "4" "100" "11.4" "7.34" "12.49" "4" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00957" "8673" "ENSG00000118640" "VAMP8" "hsa:8673; O60625; Q53SP9; Q6IB09; Q9BV40" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins" "Neutrophil degranulation; ER-Phagosome pathway; Cargo recognition for clathrin-mediated endocytosis; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis" "8" "0" "0.960" "1.016" "1.067" "0.927" "0.934" "0.956" "0.935" "0.798" "0.520" "666.1" "639.7" "676.8" "710.9" "617.8" "622.0" "636.7" "623.1" "531.3" "346.7" "" "" "" "" "" "" "" "" "" "" "352.7" "354.7" "387.6" "327.4" "334.2" "346.0" "374.7" "340.1" "298.0" "346.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3901597498303011274" "False" "High" "IsMasterProtein" "P14621" "Acylphosphatase-2 OS=Homo sapiens OX=9606 GN=ACYP2 PE=1 SV=2" "0.000" "False" "10.720" "29" "3" "3" "3" "99" "11.1" "9.50" "9.67" "3" "other metabolic processes" "" "other molecular function" "Pf00708" "98" "ENSG00000170634" "ACYP2" "hsa:98; P14621" "" "" "0" "0" "0.950" "0.979" "0.981" "0.997" "0.905" "0.931" "0.932" "0.925" "0.607" "690.0" "655.7" "675.4" "676.6" "688.1" "624.7" "642.3" "643.5" "638.6" "418.7" "" "" "" "" "" "" "" "" "" "" "365.4" "363.5" "386.8" "311.6" "372.3" "347.5" "378.0" "351.2" "358.2" "418.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3347831162215749093" "False" "High" "IsMasterProtein" "Q9UEW8" "STE20/SPS1-related proline-alanine-rich protein kinase OS=Homo sapiens OX=9606 GN=STK39 PE=1 SV=3" "0.000" "False" "10.720" "5" "2" "2" "2" "545" "59.4" "6.29" "7.57" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12202" "27347" "ENSG00000198648" "STK39" "O14774; Q53S90; Q53SL7; Q53SS1; Q9UER4; Q9UEW8; X5D9C8" "" "" "0" "0" "1.244" "1.044" "1.291" "1.109" "1.135" "1.187" "0.723" "1.046" "4.179" "65.2" "81.2" "68.1" "84.2" "72.3" "74.1" "77.4" "47.1" "68.2" "272.6" "" "" "" "" "" "" "" "" "" "" "34.5" "45.0" "39.0" "38.8" "39.1" "41.2" "45.6" "25.7" "38.3" "272.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5521793610303513807" "False" "High" "IsMasterProtein" "P52789" "Hexokinase-2 OS=Homo sapiens OX=9606 GN=HK2 PE=1 SV=2" "0.000" "False" "10.704" "3" "3" "4" "2" "917" "102.3" "6.05" "11.33" "3" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00349, Pf03727" "3099" "ENSG00000159399" "HK2" "D6W5J2; hsa:3099; P52789; Q8WU87; Q9UN82" "Clear cell renal cell carcinoma pathways; Warburg effect modulated by deubiquitinating enzymes and their substrates; Glycolysis and gluconeogenesis; Macrophage-stimulating protein (MSP) signaling network map; Metabolic Epileptic Disorders; UDP-derived sugars synthesis in fibroblasts" "Glycolysis" "7" "0" "0.909" "1.130" "0.999" "1.105" "1.317" "1.355" "0.404" "1.295" "15.029" "41.5" "37.8" "47.0" "41.5" "45.9" "54.7" "56.3" "16.8" "53.8" "624.3" "" "" "" "" "" "" "" "" "" "" "22.0" "20.9" "26.9" "19.1" "24.8" "30.4" "33.1" "9.2" "30.2" "624.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5166856508772248001" "False" "High" "IsMasterProtein" "P01111" "GTPase NRas OS=Homo sapiens OX=9606 GN=NRAS PE=1 SV=1" "0.000" "False" "10.702" "16" "3" "3" "1" "189" "21.2" "5.17" "7.60" "3" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00071" "4893" "ENSG00000213281" "NRAS" "hsa:4893; P01111; Q14971; Q15104; Q15282" "Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; TNF-alpha signaling pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; Extracellular vesicle-mediated signaling in recipient cells; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; MAPK cascade; Ras signaling; Non-small cell lung cancer; Breast cancer pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Kisspeptin/kisspeptin receptor system in the ovary; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; JAK-STAT signaling in the regulation of beta cells; ErbB signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling" "FCERI mediated MAPK activation; Regulation of RAS by GAPs; Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; Signaling by SCF-KIT; Downstream signal transduction; Tie2 Signaling; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; p38MAPK events; SHC-mediated cascade:FGFR1; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR2; FRS-mediated FGFR2 signaling; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SHC-mediated cascade:FGFR3; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; SHC-mediated cascade:FGFR4; Signaling by FGFR3 in disease; Activated NTRK2 signals through FRS2 and FRS3; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; CD209 (DC-SIGN) signaling; Activation of RAS in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants; RAS signaling downstream of NF1 loss-of-function variants; Insulin receptor signalling cascade; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; MET activates RAS signaling; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; Signaling by RAS GAP mutants; Signaling by RAS GTPase mutants" "110" "1" "0.887" "0.976" "1.015" "0.912" "0.891" "0.964" "0.988" "0.933" "0.576" "48.2" "42.7" "47.0" "48.9" "43.9" "42.9" "46.4" "47.6" "44.9" "27.7" "" "" "" "" "" "" "" "" "" "" "25.5" "23.7" "26.9" "22.5" "23.8" "23.9" "27.3" "26.0" "25.2" "27.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4533705047032389806" "False" "High" "IsMasterProtein" "P62241" "Small ribosomal subunit protein eS8 OS=Homo sapiens OX=9606 GN=RPS8 PE=1 SV=2" "0.000" "False" "10.693" "16" "3" "3" "3" "208" "24.2" "10.32" "9.78" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01201" "6202" "ENSG00000142937" "RPS8" "hsa:6202; P09058; P62241; Q6IRL7" "Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.044" "0.676" "1.545" "1.064" "0.990" "1.095" "0.832" "0.807" "1.402" "90.4" "94.4" "61.2" "139.7" "96.2" "89.5" "99.1" "75.3" "73.0" "126.8" "" "" "" "" "" "" "" "" "" "" "47.9" "52.3" "35.0" "64.3" "52.1" "49.8" "58.3" "41.1" "40.9" "126.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1698483045954744258" "False" "High" "IsMasterProtein" "Q15018" "BRISC complex subunit Abraxas 2 OS=Homo sapiens OX=9606 GN=ABRAXAS2 PE=1 SV=2" "0.000" "False" "10.685" "10" "4" "7" "4" "415" "46.9" "6.21" "11.18" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf21125" "23172" "ENSG00000165660" "ABRAXAS2" "B4DKR2; hsa:23172; Q15018; Q96H11" "" "Metalloprotease DUBs" "1" "0" "2.981" "0.894" "2.772" "3.793" "1.679" "1.281" "1.428" "1.872" "0.629" "487.3" "1452.5" "435.7" "1350.9" "1848.2" "818.3" "624.2" "695.6" "912.4" "306.6" "" "" "" "" "" "" "" "" "" "" "258.0" "805.3" "249.5" "622.1" "999.9" "455.2" "367.4" "379.7" "511.8" "306.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5898955459380036323" "False" "High" "IsMasterProtein" "Q05048" "Cleavage stimulation factor subunit 1 OS=Homo sapiens OX=9606 GN=CSTF1 PE=1 SV=1" "0.000" "False" "10.661" "8" "3" "4" "3" "431" "48.3" "6.58" "11.38" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00400, Pf16699" "1477" "ENSG00000101138" "CSTF1" "hsa:1477; Q05048; Q5QPD8" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "1.058" "1.061" "0.948" "0.996" "1.130" "1.082" "1.054" "1.044" "0.736" "278.7" "294.8" "295.7" "264.3" "277.7" "315.1" "301.7" "293.8" "291.0" "205.1" "" "" "" "" "" "" "" "" "" "" "147.6" "163.4" "169.4" "121.7" "150.2" "175.3" "177.5" "160.4" "163.2" "205.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3180744532399736086" "False" "High" "IsMasterProtein" "Q15814" "Tubulin-specific chaperone C OS=Homo sapiens OX=9606 GN=TBCC PE=1 SV=2" "0.000" "False" "10.661" "9" "4" "6" "3" "346" "39.2" "5.71" "17.24" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf07986, Pf16752" "6903" "ENSG00000124659" "TBCC" "hsa:6903; Q15814; Q53Y43; Q5T787" "" "Post-chaperonin tubulin folding pathway" "1" "0" "1.015" "0.965" "0.970" "1.044" "1.024" "0.961" "0.997" "0.952" "0.816" "304.2" "308.8" "293.5" "295.1" "317.7" "311.6" "292.4" "303.2" "289.5" "248.4" "" "" "" "" "" "" "" "" "" "" "161.1" "171.2" "168.1" "135.9" "171.9" "173.3" "172.1" "165.5" "162.4" "248.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3472433998448837783" "False" "High" "IsMasterProtein" "O75323" "Protein NipSnap homolog 2 OS=Homo sapiens OX=9606 GN=NIPSNAP2 PE=1 SV=1" "0.000" "False" "10.660" "9" "3" "4" "2" "286" "33.7" "9.36" "12.66" "3" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;mitochondrion" "" "Pf07978" "2631" "ENSG00000146729" "NIPSNAP2" "C9IYJ3; hsa:2631; O43801; O75323; Q53X96" "" "RHOJ GTPase cycle; RHOH GTPase cycle" "2" "1" "0.932" "1.022" "0.778" "0.905" "0.993" "0.804" "0.936" "0.900" "0.565" "1690.3" "1575.1" "1726.9" "1314.8" "1529.8" "1677.8" "1359.2" "1582.7" "1521.7" "955.5" "" "" "" "" "" "" "" "" "" "" "895.0" "873.3" "989.0" "605.5" "827.7" "933.3" "800.0" "863.9" "853.7" "955.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8206347650273111002" "False" "High" "IsMasterProtein" "Q9H7C9" "Mth938 domain-containing protein OS=Homo sapiens OX=9606 GN=AAMDC PE=1 SV=1" "0.000" "False" "10.647" "22" "3" "4" "3" "122" "13.3" "8.46" "12.16" "3" "other biological processes" "other cell component" "" "Pf04430" "28971" "ENSG00000087884" "AAMDC" "hsa:28971; Q96AQ4; Q9H7C9; Q9Y6B1" "" "" "0" "0" "0.910" "0.949" "0.948" "0.949" "0.946" "0.860" "0.913" "0.931" "0.702" "335.8" "305.5" "318.7" "318.4" "318.7" "317.8" "288.9" "306.7" "312.5" "235.8" "" "" "" "" "" "" "" "" "" "" "177.8" "169.4" "182.5" "146.6" "172.4" "176.8" "170.0" "167.4" "175.3" "235.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-911764670660096816" "False" "High" "IsMasterProtein" "P08195" "Amino acid transporter heavy chain SLC3A2 OS=Homo sapiens OX=9606 GN=SLC3A2 PE=1 SV=3" "0.000" "False" "10.642" "5" "3" "4" "3" "630" "68.0" "5.01" "9.49" "3" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;nucleic acid binding activity;other molecular function" "Pf00128, Pf16028" "6520" "ENSG00000168003" "SLC3A2" "hsa:6520; J3KPF3; P08195; Q13543" "mRNA, protein, and metabolite inducation pathway by cyclosporin A; Ferroptosis; Proximal tubule transport; Pleural mesothelioma" "Tryptophan catabolism; Basigin interactions; Amino acid transport across the plasma membrane; Defective SLC7A7 causes lysinuric protein intolerance (LPI)" "8" "0" "1.279" "1.172" "1.398" "1.179" "1.316" "1.304" "1.370" "1.150" "0.496" "55.4" "70.8" "64.9" "77.4" "65.3" "72.9" "72.3" "75.9" "63.7" "27.5" "" "" "" "" "" "" "" "" "" "" "29.3" "39.3" "37.2" "35.7" "35.3" "40.5" "42.5" "41.4" "35.7" "27.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6930052097087835026" "False" "High" "IsMasterProtein" "Q15003" "Condensin complex subunit 2 OS=Homo sapiens OX=9606 GN=NCAPH PE=1 SV=3" "0.000" "False" "10.636" "4" "3" "4" "3" "741" "82.5" "5.06" "5.52" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05786" "23397" "ENSG00000121152" "NCAPH" "B4E189; hsa:23397; Q15003; Q8TB87" "2q11.2 copy number variation syndrome" "Condensation of Prometaphase Chromosomes" "2" "0" "1.057" "0.920" "1.195" "1.098" "1.097" "1.195" "1.014" "1.199" "3.772" "105.4" "111.4" "96.9" "125.9" "115.7" "115.6" "125.9" "106.8" "126.4" "397.4" "" "" "" "" "" "" "" "" "" "" "55.8" "61.7" "55.5" "58.0" "62.6" "64.3" "74.1" "58.3" "70.9" "397.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5250221047475229599" "False" "High" "IsMasterProtein" "Q7LBC6" "Lysine-specific demethylase 3B OS=Homo sapiens OX=9606 GN=KDM3B PE=1 SV=2" "0.000" "False" "10.627" "2" "4" "4" "4" "1761" "191.5" "7.18" "8.55" "4" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "51780" "ENSG00000120733" "KDM3B" "A6H8X7; hsa:51780; Q7LBC6; Q9BVH6; Q9BW93; Q9BZ52; Q9NYF4; Q9UPS0" "Thermogenesis" "HDMs demethylate histones" "2" "0" "1.170" "1.018" "1.127" "1.080" "1.114" "1.307" "1.013" "1.276" "4.611" "127.2" "148.8" "129.5" "143.3" "137.5" "141.7" "166.3" "128.9" "162.4" "586.7" "" "" "" "" "" "" "" "" "" "" "67.4" "82.5" "74.1" "66.0" "74.4" "78.8" "97.8" "70.3" "91.1" "586.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4669719094448447392" "False" "High" "IsMasterProtein" "Q9BSJ8" "Extended synaptotagmin-1 OS=Homo sapiens OX=9606 GN=ESYT1 PE=1 SV=1" "0.000" "False" "10.622" "2" "2" "2" "2" "1104" "122.8" "5.83" "7.49" "2" "cell organization and biogenesis;transport" "plasma membrane;other membranes;ER/Golgi" "transporter activity;other molecular function" "Pf00168, Pf17047" "23344" "ENSG00000139641" "ESYT1" "A0FGR7; A8K2S2; hsa:23344; O94848; Q6PJN4; Q9BSJ8; Q9H6J1; Q9H6W2; Q9Y416" "" "RHOG GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; Glycosphingolipid transport; RHOF GTPase cycle" "7" "0" "1.066" "1.082" "1.534" "1.266" "1.254" "1.854" "1.664" "1.659" "1.318" "185.4" "197.7" "200.6" "284.5" "234.8" "232.5" "343.8" "308.6" "307.6" "244.5" "" "" "" "" "" "" "" "" "" "" "98.2" "109.6" "114.9" "131.0" "127.0" "129.3" "202.4" "168.4" "172.5" "244.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-242309002880936469" "False" "High" "IsMasterProtein" "Q8NI27" "THO complex subunit 2 OS=Homo sapiens OX=9606 GN=THOC2 PE=1 SV=2" "0.000" "False" "10.604" "2" "4" "4" "4" "1593" "182.7" "8.44" "9.26" "4" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf11262, Pf11732, Pf16134" "57187" "ENSG00000125676" "THOC2" "A6NM50; hsa:57187; Q5JZ12; Q6IN92; Q8NI27; Q9H8I6" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "1.011" "0.971" "1.056" "1.028" "0.981" "0.894" "0.887" "1.128" "2.552" "363.2" "367.3" "352.8" "383.6" "373.3" "356.4" "324.7" "322.1" "409.9" "927.1" "" "" "" "" "" "" "" "" "" "" "192.3" "203.6" "202.0" "176.7" "202.0" "198.2" "191.1" "175.8" "229.9" "927.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7404612744659791932" "False" "High" "IsMasterProtein" "Q01658" "Protein Dr1 OS=Homo sapiens OX=9606 GN=DR1 PE=1 SV=1" "0.000" "False" "10.603" "12" "2" "4" "2" "176" "19.4" "4.75" "11.41" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "1810" "ENSG00000117505" "DR1" "hsa:1810; Q01658" "" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "2" "0" "1.161" "1.141" "1.115" "1.214" "1.176" "1.185" "1.289" "0.974" "0.580" "78.3" "90.8" "89.3" "87.3" "95.0" "92.0" "92.8" "100.9" "76.2" "45.4" "" "" "" "" "" "" "" "" "" "" "41.4" "50.4" "51.1" "40.2" "51.4" "51.2" "54.6" "55.1" "42.7" "45.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2764493771843335681" "False" "High" "IsMasterProtein" "P08651" "Nuclear factor 1 C-type OS=Homo sapiens OX=9606 GN=NFIC PE=1 SV=2" "0.000" "False" "10.589" "6" "3" "4" "2" "508" "55.6" "8.38" "11.17" "3" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00859, Pf03165, Pf10524" "4782" "ENSG00000141905" "NFIC" "A8K1H0; B7Z4U5; B7Z9C3; hsa:4782; K7EMU1; P08651; P08652; Q14932; Q9UPJ3; Q9UPJ9; Q9UPK0; Q9UPK1" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination" "2" "1" "1.153" "0.987" "1.160" "1.114" "1.088" "1.071" "1.006" "1.057" "1.532" "265.6" "306.3" "262.1" "308.2" "295.9" "288.9" "284.6" "267.2" "280.8" "406.8" "" "" "" "" "" "" "" "" "" "" "140.6" "169.8" "150.1" "141.9" "160.1" "160.7" "167.5" "145.8" "157.5" "406.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1575206036117319314" "False" "High" "IsMasterProtein" "Q9Y608" "Leucine-rich repeat flightless-interacting protein 2 OS=Homo sapiens OX=9606 GN=LRRFIP2 PE=1 SV=1" "0.000" "False" "10.582" "4" "3" "6" "2" "721" "82.1" "6.95" "15.12" "3" "cell-cell signaling;signal transduction;other biological processes" "" "other molecular function" "Pf09738" "9209" "ENSG00000093167" "LRRFIP2" "A8K649; A8MXR0; B4DY63; Q68CV3; Q9NXH5; Q9Y608" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.385" "0.834" "1.401" "1.321" "1.148" "1.468" "1.198" "1.280" "0.680" "27.8" "38.6" "23.2" "39.0" "36.8" "32.0" "40.9" "33.4" "35.6" "18.9" "" "" "" "" "" "" "" "" "" "" "14.7" "21.4" "13.3" "18.0" "19.9" "17.8" "24.0" "18.2" "20.0" "18.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6687881647514235914" "False" "High" "IsMasterProtein" "Q147X3" "N-alpha-acetyltransferase 30 OS=Homo sapiens OX=9606 GN=NAA30 PE=1 SV=1" "0.000" "False" "10.542" "7" "2" "3" "2" "362" "39.3" "5.52" "10.08" "2" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "122830" "ENSG00000139977" "NAA30" "hsa:122830; Q0IIN2; Q147X3" "Metapathway biotransformation Phase I and II" "Retrograde transport at the Trans-Golgi-Network" "2" "0" "0.995" "0.994" "1.018" "1.069" "1.012" "0.891" "0.911" "0.888" "0.890" "458.6" "456.5" "456.1" "467.0" "490.4" "464.3" "408.5" "417.6" "407.5" "408.1" "" "" "" "" "" "" "" "" "" "" "242.9" "253.1" "261.2" "215.1" "265.3" "258.3" "240.4" "228.0" "228.6" "408.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "370565265455321105" "False" "High" "IsMasterProtein" "Q8IU81" "Interferon regulatory factor 2-binding protein 1 OS=Homo sapiens OX=9606 GN=IRF2BP1 PE=1 SV=1" "0.000" "False" "10.541" "8" "4" "4" "4" "584" "61.6" "8.18" "7.41" "4" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf11261" "26145" "ENSG00000170604" "IRF2BP1" "Q53EL7; Q6DC95; Q8IU81; Q9BRZ9; Q9Y4P4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1630996109560083637" "False" "High" "IsMasterProtein" "O75909" "Cyclin-K OS=Homo sapiens OX=9606 GN=CCNK PE=1 SV=2" "0.000" "False" "10.538" "7" "3" "3" "3" "580" "64.2" "8.41" "7.56" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00134, Pf21797" "8812" "ENSG00000090061" "CCNK" "hsa:8812; O75909; Q59FT6; Q86U16; Q96B63; Q9NNY9" "Male infertility" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes" "10" "0" "1.313" "1.121" "1.449" "1.265" "1.137" "1.300" "1.289" "1.202" "0.911" "162.8" "213.7" "182.4" "235.8" "205.8" "185.1" "211.6" "209.7" "195.6" "148.3" "" "" "" "" "" "" "" "" "" "" "86.2" "118.5" "104.4" "108.6" "111.3" "102.9" "124.5" "114.5" "109.7" "148.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5846443296709188562" "False" "High" "IsMasterProtein" "Q9Y248" "DNA replication complex GINS protein PSF2 OS=Homo sapiens OX=9606 GN=GINS2 PE=1 SV=1" "0.000" "False" "10.538" "16" "3" "4" "3" "185" "21.4" "5.44" "7.54" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus" "" "Pf05916" "51659" "ENSG00000131153" "GINS2" "D3DUM5; hsa:51659; Q6IAG9; Q9Y248" "" "Unwinding of DNA" "1" "0" "1.002" "0.982" "0.853" "0.962" "0.965" "0.880" "0.811" "0.759" "1.201" "232.6" "233.1" "228.4" "198.5" "223.8" "224.4" "204.6" "188.6" "176.6" "279.4" "" "" "" "" "" "" "" "" "" "" "123.2" "129.2" "130.8" "91.4" "121.1" "124.8" "120.4" "102.9" "99.1" "279.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5929165091375925329" "False" "High" "IsMasterProtein" "Q15545" "Transcription initiation factor TFIID subunit 7 OS=Homo sapiens OX=9606 GN=TAF7 PE=1 SV=1" "0.000" "False" "10.532" "5" "2" "2" "2" "349" "40.2" "5.20" "6.73" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04658" "6879" "ENSG00000178913" "TAF7" "B2RBV9; hsa:6879; Q13036; Q15545" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation" "10" "0" "0.986" "0.878" "1.058" "0.843" "0.995" "0.991" "1.041" "0.919" "1.112" "170.3" "168.0" "149.5" "180.3" "143.6" "169.4" "168.9" "177.3" "156.6" "189.5" "" "" "" "" "" "" "" "" "" "" "90.2" "93.1" "85.6" "83.0" "77.7" "94.2" "99.4" "96.8" "87.9" "189.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "938742805709954505" "False" "High" "IsMasterProtein" "Q9H3F6" "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 OS=Homo sapiens OX=9606 GN=KCTD10 PE=1 SV=1" "0.000" "False" "10.523" "8" "2" "3" "2" "313" "35.4" "6.34" "8.71" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02214" "83892" "ENSG00000110906" "KCTD10" "hsa:83892; Q53HN2; Q59FV1; Q6PL47; Q96SU0; Q9H3F6" "" "" "0" "0" "1.061" "0.912" "1.109" "1.078" "0.943" "1.027" "0.922" "1.000" "0.798" "170.6" "181.1" "155.5" "189.2" "184.0" "160.9" "175.2" "157.2" "170.5" "136.2" "" "" "" "" "" "" "" "" "" "" "90.3" "100.4" "89.1" "87.1" "99.5" "89.5" "103.1" "85.8" "95.7" "136.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3119089922168410835" "False" "High" "IsMasterProtein" "P10606" "Cytochrome c oxidase subunit 5B, mitochondrial OS=Homo sapiens OX=9606 GN=COX5B PE=1 SV=2" "0.000" "False" "10.506" "16" "2" "6" "2" "129" "13.7" "8.81" "15.62" "2" "other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf01215" "1329" "ENSG00000135940; ENSG00000291596" "COX5B" "hsa:1329; P10606; Q53YB7; Q96J18; Q99610" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Mitochondrial protein degradation" "8" "0" "1.030" "1.034" "0.997" "1.017" "0.933" "1.055" "0.963" "1.004" "0.615" "268.1" "276.2" "277.2" "267.4" "272.6" "250.1" "282.8" "258.3" "269.1" "164.9" "" "" "" "" "" "" "" "" "" "" "142.0" "153.1" "158.7" "123.2" "147.5" "139.1" "166.4" "141.0" "150.9" "164.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3086265819139452668" "False" "High" "IsMasterProtein" "O14773" "Tripeptidyl-peptidase 1 OS=Homo sapiens OX=9606 GN=TPP1 PE=1 SV=2" "0.000" "False" "10.498" "6" "3" "3" "3" "563" "61.2" "6.48" "8.99" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00082, Pf09286" "1200" "ENSG00000166340" "TPP1" "hsa:1200; O14773; Q53HT1; Q5JAK6; Q6UX56; Q71JP6; Q96C37" "VEGFA-VEGFR2 signaling" "XBP1(S) activates chaperone genes" "2" "0" "1.137" "0.981" "1.159" "1.144" "1.055" "1.033" "0.977" "1.002" "0.746" "281.8" "320.5" "276.3" "326.5" "322.4" "297.2" "291.0" "275.2" "282.3" "210.3" "" "" "" "" "" "" "" "" "" "" "149.2" "177.7" "158.2" "150.4" "174.4" "165.3" "171.3" "150.2" "158.4" "210.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7043086942307680796" "False" "High" "IsMasterProtein" "P63220" "Small ribosomal subunit protein eS21 OS=Homo sapiens OX=9606 GN=RPS21 PE=1 SV=1" "0.000" "False" "10.498" "37" "3" "5" "3" "83" "9.1" "8.50" "14.59" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01249" "6227" "ENSG00000171858" "RPS21" "hsa:6227; P35265; P63220" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.052" "0.988" "1.170" "1.274" "1.064" "1.467" "1.449" "1.553" "0.634" "422.8" "444.9" "418.0" "494.6" "538.5" "449.7" "620.1" "612.7" "656.7" "267.9" "" "" "" "" "" "" "" "" "" "" "223.9" "246.7" "239.4" "227.8" "291.4" "250.1" "364.9" "334.4" "368.4" "267.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6145009283245857027" "False" "High" "IsMasterProtein" "P62487" "DNA-directed RNA polymerase II subunit RPB7 OS=Homo sapiens OX=9606 GN=POLR2G PE=1 SV=1" "0.000" "False" "10.481" "13" "2" "3" "2" "172" "19.3" "5.54" "8.39" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00575, Pf03876" "5436" "ENSG00000168002" "POLR2G" "B2R5C0; hsa:5436; P52433; P62487; Q2M1Z4" "Pyrimidine metabolism; Eukaryotic transcription initiation" "Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "43" "0" "0.965" "1.030" "1.296" "1.210" "1.100" "1.095" "1.303" "1.160" "0.769" "146.3" "141.2" "150.7" "189.5" "177.0" "160.9" "160.3" "190.6" "169.6" "112.5" "" "" "" "" "" "" "" "" "" "" "77.5" "78.3" "86.3" "87.3" "95.8" "89.5" "94.3" "104.0" "95.2" "112.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3788247885213699411" "False" "High" "IsMasterProtein" "P04233" "HLA class II histocompatibility antigen gamma chain OS=Homo sapiens OX=9606 GN=CD74 PE=1 SV=3" "0.000" "False" "10.463" "10" "3" "7" "3" "296" "33.5" "8.44" "13.24" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00086, Pf08831, Pf09307" "972" "ENSG00000019582" "CD74" "A8K7R1; B4DNE8; D3DQG3; D3DQG4; hsa:972; P04233; Q14597; Q29832; Q5U0J8; Q8SNA0; Q8WLP6" "Macrophage markers" "MHC class II antigen presentation; Cell surface interactions at the vascular wall" "3" "0" "1.091" "1.080" "1.010" "1.123" "1.058" "0.985" "0.927" "0.921" "0.799" "77.5" "84.5" "83.7" "78.3" "87.0" "82.0" "76.3" "71.9" "71.4" "61.9" "" "" "" "" "" "" "" "" "" "" "41.0" "46.8" "47.9" "36.0" "47.1" "45.6" "44.9" "39.2" "40.0" "61.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6550652705279003104" "False" "High" "IsMasterProtein" "P50552" "Vasodilator-stimulated phosphoprotein OS=Homo sapiens OX=9606 GN=VASP PE=1 SV=3" "0.000" "False" "10.461" "8" "4" "4" "4" "380" "39.8" "8.94" "8.31" "4" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00568, Pf08776" "7408" "ENSG00000125753" "VASP" "B2RBT9; hsa:7408; P50552; Q6PIZ1; Q93035" "Integrin-mediated cell adhesion; Focal adhesion" "Generation of second messenger molecules; Signaling by ROBO receptors; Cell-extracellular matrix interactions" "5" "0" "1.054" "1.026" "1.096" "1.034" "1.071" "1.081" "1.047" "1.089" "1.901" "300.6" "316.9" "308.3" "329.4" "310.8" "322.0" "324.9" "314.6" "327.3" "571.2" "" "" "" "" "" "" "" "" "" "" "159.1" "175.7" "176.5" "151.7" "168.1" "179.1" "191.2" "171.7" "183.6" "571.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5140965250815444674" "False" "High" "IsMasterProtein" "Q9ULJ6" "Zinc finger MIZ domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZMIZ1 PE=1 SV=3" "0.000" "False" "10.454" "2" "3" "4" "3" "1067" "115.4" "7.46" "11.58" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02891, Pf18028" "57178" "ENSG00000108175" "ZMIZ1" "hsa:57178; Q5JSH9; Q7Z7E6; Q9ULJ6" "Androgen receptor signaling pathway" "" "1" "0" "1.038" "1.064" "1.043" "1.115" "1.113" "1.051" "1.012" "0.998" "0.699" "324.7" "337.1" "345.6" "338.6" "362.1" "361.4" "341.4" "328.6" "324.2" "227.1" "" "" "" "" "" "" "" "" "" "" "171.9" "186.9" "197.9" "155.9" "195.9" "201.0" "200.9" "179.4" "181.9" "227.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4066776278631376418" "False" "High" "IsMasterProtein" "P17612" "cAMP-dependent protein kinase catalytic subunit alpha OS=Homo sapiens OX=9606 GN=PRKACA PE=1 SV=2" "0.000" "False" "10.427" "9" "4" "6" "2" "351" "40.6" "8.79" "13.18" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5566" "ENSG00000072062; ENSG00000288516" "PRKACA" "hsa:5566; P17612; Q32P54; Q9H2Y0; Q9NRB4; Q9NRH9" "Nicotine effect on dopaminergic neurons; Sterol regulatory element-binding proteins (SREBP) signaling; Follicle stimulating hormone (FSH) signaling pathway; Microtubule cytoskeleton regulation; Dopamine metabolism; Common pathways underlying drug addiction; Complement system; Mesodermal commitment pathway; IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mesodermal commitment pathway; G protein signaling pathways; MAPK signaling pathway; Cannabinoid receptor signaling; Lipid metabolism pathway; Phosphodiesterases in neuronal function; Ras signaling; Hedgehog signaling pathway; Thermogenesis; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; GPR143 in melanocytes and retinal pigment epithelium cells; Neuroinflammation and glutamatergic signaling; Vasopressin-regulated water reabsorption; GDNF signaling; Urotensin-II-mediated signaling pathway; Calcium regulation in cardiac cells; KCNQ2-related epilepsies; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Mitochondrial protein degradation; VEGFA-VEGFR2 Pathway; FCGR3A-mediated IL10 synthesis; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Triglyceride catabolism; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Ion homeostasis; Interleukin-3, Interleukin-5 and GM-CSF signaling; RET signaling; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; Regulation of MECP2 expression and activity; PKA activation; PKA activation in glucagon signalling; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; CD209 (DC-SIGN) signaling; Rap1 signalling; HDL assembly; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase; Loss of phosphorylation of MECP2 at T308; ROBO receptors bind AKAP5; PKA-mediated phosphorylation of key metabolic factors" "75" "0" "0.927" "0.986" "1.008" "0.934" "0.983" "0.916" "0.925" "0.974" "1.076" "182.4" "169.1" "179.9" "184.0" "170.4" "179.3" "167.2" "168.7" "177.7" "196.4" "" "" "" "" "" "" "" "" "" "" "96.6" "93.7" "103.0" "84.7" "92.2" "99.7" "98.4" "92.1" "99.7" "196.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3276103228213200498" "False" "High" "IsMasterProtein" "P62308" "Small nuclear ribonucleoprotein G OS=Homo sapiens OX=9606 GN=SNRPG PE=1 SV=1" "0.000" "False" "10.426" "25" "2" "10" "2" "76" "8.5" "8.88" "18.86" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf01423" "6637" "ENSG00000143977" "SNRPG" "D6W5G6; hsa:6637; P62308; Q15357; Q6IB86" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; RNA Polymerase II Transcription Termination; snRNP Assembly; SARS-CoV-2 modulates host translation machinery; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "8" "0" "1.114" "1.045" "1.242" "1.168" "1.139" "1.290" "1.346" "1.337" "0.561" "414.0" "461.2" "432.4" "514.0" "483.4" "471.7" "533.9" "557.2" "553.4" "232.4" "" "" "" "" "" "" "" "" "" "" "219.2" "255.7" "247.6" "236.7" "261.5" "262.4" "314.2" "304.2" "310.4" "232.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3563159699507819169" "False" "High" "IsMasterProtein" "P06280" "Alpha-galactosidase A OS=Homo sapiens OX=9606 GN=GLA PE=1 SV=1" "0.000" "False" "10.420" "4" "2" "4" "2" "429" "48.7" "5.60" "11.07" "2" "other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf16499, Pf17450" "2717" "ENSG00000102393" "GLA" "hsa:2717; P06280; Q6LER7" "Degradation pathway of sphingolipids, including diseases; Ciliary landscape" "Neutrophil degranulation; Glycosphingolipid catabolism" "4" "0" "1.020" "1.067" "1.010" "1.004" "1.048" "1.013" "1.019" "1.019" "0.553" "362.4" "369.7" "386.7" "365.9" "363.8" "379.7" "367.2" "369.2" "369.2" "200.4" "" "" "" "" "" "" "" "" "" "" "191.9" "205.0" "221.5" "168.5" "196.8" "211.2" "216.1" "201.5" "207.1" "200.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5798091253452066801" "False" "High" "IsMasterProtein" "Cont_Q86YZ3" "Hornerin OS=Homo sapiens OX=9606 GN=HRNR PE=1 SV=2" "0.000" "True" "10.408" "5" "3" "3" "3" "2850" "282.2" "10.04" "8.97" "3" "cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01023" "388697" "ENSG00000197915" "HRNR" "hsa:388697; Q5DT20; Q5U1F4; Q86YZ3" "" "Neutrophil degranulation" "1" "0" "5.314" "0.863" "0.776" "0.676" "1.128" "1.393" "1.056" "0.702" "0.991" "149.3" "793.5" "128.9" "115.9" "100.9" "168.5" "208.0" "157.7" "104.8" "148.0" "" "" "" "" "" "" "" "" "" "" "79.1" "439.9" "73.8" "53.4" "54.6" "93.7" "122.4" "86.1" "58.8" "148.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4186240485352530352" "False" "High" "IsMasterProtein" "Q96SI1" "BTB/POZ domain-containing protein KCTD15 OS=Homo sapiens OX=9606 GN=KCTD15 PE=1 SV=1" "0.000" "False" "10.408" "10" "3" "4" "3" "283" "31.9" "7.44" "10.42" "3" "cell organization and biogenesis" "nucleus" "other molecular function" "Pf02214, Pf20871" "79047" "ENSG00000153885" "KCTD15" "A8K600; hsa:79047; Q96SI1; Q9BVI6" "" "Negative regulation of activity of TFAP2 (AP-2) family transcription factors" "1" "0" "0.939" "1.028" "1.080" "1.039" "0.980" "0.947" "1.039" "0.972" "0.706" "484.6" "455.1" "497.9" "523.2" "503.3" "474.7" "458.9" "503.5" "471.1" "342.1" "" "" "" "" "" "" "" "" "" "" "256.6" "252.3" "285.1" "240.9" "272.3" "264.0" "270.1" "274.8" "264.3" "342.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3858679499056122524" "False" "High" "IsMasterProtein" "P53370" "Nucleoside diphosphate-linked moiety X motif 6 OS=Homo sapiens OX=9606 GN=NUDT6 PE=1 SV=2" "0.000" "False" "10.405" "9" "3" "3" "3" "316" "35.7" "8.00" "9.35" "3" "other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00293, Pf18290" "11162" "ENSG00000170917" "NUDT6" "A8K756; hsa:11162; O95097; P53370; Q9UQD9" "" "" "0" "0" "0.933" "0.922" "1.015" "0.932" "1.008" "0.931" "0.916" "0.985" "0.773" "451.0" "420.8" "416.0" "458.0" "420.4" "454.6" "420.0" "413.3" "444.2" "348.6" "" "" "" "" "" "" "" "" "" "" "238.8" "233.3" "238.2" "210.9" "227.4" "252.8" "247.2" "225.6" "249.2" "348.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5470294891726501754" "False" "High" "IsMasterProtein" "P61962" "DDB1- and CUL4-associated factor 7 OS=Homo sapiens OX=9606 GN=DCAF7 PE=1 SV=1" "0.000" "False" "10.400" "9" "3" "3" "3" "342" "38.9" "5.52" "9.41" "3" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "10238" "ENSG00000136485" "DCAF7" "B4E039; D3DU14; hsa:10238; O15491; P61962; Q9DAE4" "Ciliary landscape; DYRK1A involvement regarding cell proliferation in brain development" "Neddylation; Association of TriC/CCT with target proteins during biosynthesis" "4" "0" "1.053" "1.047" "1.031" "1.080" "1.035" "1.045" "0.999" "1.048" "1.108" "576.4" "606.9" "603.2" "594.2" "622.3" "596.4" "602.3" "575.8" "604.1" "638.5" "" "" "" "" "" "" "" "" "" "" "305.2" "336.5" "345.5" "273.6" "336.7" "331.8" "354.5" "314.3" "338.9" "638.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "185652229165611282" "False" "High" "IsMasterProtein" "Q9NY27" "Serine/threonine-protein phosphatase 4 regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PPP4R2 PE=1 SV=3" "0.000" "False" "10.396" "9" "4" "4" "4" "417" "46.9" "4.54" "9.56" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf09184" "151987" "ENSG00000163605" "PPP4R2" "A8K1I6; hsa:151987; Q2TAJ9; Q498B8; Q8WXX6; Q9NY27" "16p11.2 proximal deletion syndrome" "Processing of DNA double-strand break ends" "2" "0" "1.025" "0.942" "0.863" "0.998" "1.088" "0.904" "0.993" "1.069" "1.222" "270.9" "277.6" "255.2" "233.7" "270.4" "294.8" "244.9" "269.0" "289.7" "331.0" "" "" "" "" "" "" "" "" "" "" "143.5" "153.9" "146.1" "107.6" "146.3" "164.0" "144.1" "146.8" "162.5" "331.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1466786555444396810" "False" "High" "IsMasterProtein" "Q12933" "TNF receptor-associated factor 2 OS=Homo sapiens OX=9606 GN=TRAF2 PE=1 SV=2" "0.000" "False" "10.394" "7" "4" "5" "4" "501" "55.8" "7.53" "12.05" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00097, Pf02176, Pf16673, Pf21341, Pf21355" "7186" "ENSG00000127191" "TRAF2" "A8K107; B4DPJ7; hsa:7186; Q12933; Q7Z337; Q96NT2" "RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Apoptosis; Photodynamic therapy-induced AP-1 survival signaling; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; Oxidative damage response; p38 MAPK signaling pathway; Nonalcoholic fatty liver disease; Small cell lung cancer; 16p11.2 proximal deletion syndrome; 16p11.2 distal deletion syndrome; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Pleural mesothelioma; Alzheimer's disease; 1p36 copy number variation syndrome; 13q12.12 copy number variation; 8q11.23 (RB1CC1) copy number variation" "Ub-specific processing proteases; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TRAF6 mediated NF-kB activation; Regulation of NF-kappa B signaling; TNFR1-induced proapoptotic signaling; TRAF6 mediated IRF7 activation; Defective RIPK1-mediated regulated necrosis" "37" "0" "1.233" "0.944" "0.846" "1.061" "1.026" "0.961" "0.984" "0.916" "0.587" "394.9" "487.0" "372.9" "334.3" "418.9" "405.3" "379.7" "388.4" "361.8" "231.7" "" "" "" "" "" "" "" "" "" "" "209.1" "270.0" "213.5" "153.9" "226.6" "225.4" "223.5" "212.0" "203.0" "231.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5779447610884953183" "False" "High" "IsMasterProtein" "Q9NPD8" "Ubiquitin-conjugating enzyme E2 T OS=Homo sapiens OX=9606 GN=UBE2T PE=1 SV=1" "0.000" "False" "10.393" "15" "2" "2" "2" "197" "22.5" "7.99" "5.99" "2" "protein metabolism;DNA metabolism;other metabolic processes;stress response" "nucleus" "other molecular function" "Pf00179" "29089" "ENSG00000077152" "UBE2T" "hsa:29089; Q2TU36; Q9NPD8" "Gastric cancer network 2" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Fanconi Anemia Pathway" "3" "0" "0.900" "1.087" "0.989" "1.464" "1.212" "1.205" "1.146" "1.040" "1.228" "37.7" "33.9" "41.0" "37.3" "55.2" "45.7" "45.5" "43.2" "39.2" "46.3" "" "" "" "" "" "" "" "" "" "" "20.0" "18.8" "23.5" "17.2" "29.9" "25.4" "26.8" "23.6" "22.0" "46.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4412220755654312839" "False" "High" "IsMasterProtein" "Q15652" "Probable JmjC domain-containing histone demethylation protein 2C OS=Homo sapiens OX=9606 GN=JMJD1C PE=1 SV=2" "0.000" "False" "10.361" "1" "3" "3" "3" "2540" "284.3" "7.87" "7.95" "3" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "221037" "ENSG00000171988" "JMJD1C" "A0T124; hsa:221037; Q15652; Q5SQZ8; Q5SQZ9; Q5SR00; Q7Z3E7; Q8N3U0; Q96KB9; Q9P2G7" "Pathways affected in adenoid cystic carcinoma" "Factors involved in megakaryocyte development and platelet production" "2" "0" "0.925" "0.845" "1.036" "0.984" "0.926" "1.168" "1.228" "1.039" "0.984" "335.9" "310.6" "284.0" "348.0" "330.6" "311.0" "392.3" "412.6" "349.0" "330.7" "" "" "" "" "" "" "" "" "" "" "177.9" "172.2" "162.6" "160.3" "178.9" "173.0" "230.9" "225.2" "195.8" "330.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7145479494712382587" "False" "High" "IsMasterProtein" "P80217" "Interferon-induced 35 kDa protein OS=Homo sapiens OX=9606 GN=IFI35 PE=1 SV=5" "0.000" "False" "10.358" "12" "4" "5" "4" "286" "31.5" "6.09" "13.52" "4" "stress response;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf07292, Pf07334" "3430" "ENSG00000068079" "IFI35" "C9JGX1; hsa:3430; P80217; Q92984; Q99537; Q9BV98" "Immune response to tuberculosis" "Interferon alpha/beta signaling" "2" "0" "1.024" "0.946" "1.259" "1.020" "0.893" "1.077" "0.881" "0.865" "0.520" "731.7" "749.4" "692.3" "921.2" "746.5" "653.1" "788.0" "644.5" "632.9" "380.8" "" "" "" "" "" "" "" "" "" "" "387.4" "415.5" "396.5" "424.2" "403.9" "363.3" "463.8" "351.8" "355.0" "380.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "756136000491077603" "False" "High" "IsMasterProtein" "P08236" "Beta-glucuronidase OS=Homo sapiens OX=9606 GN=GUSB PE=1 SV=2" "0.000" "False" "10.326" "5" "4" "4" "4" "651" "74.7" "7.02" "10.42" "4" "protein metabolism;other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00703, Pf02836, Pf02837" "2990" "ENSG00000169919" "GUSB" "B4E1F6; E9PCV0; hsa:2990; P08236; Q549U0; Q96CL9" "Glycosaminoglycan degradation" "Neutrophil degranulation; HS-GAG degradation; Hyaluronan uptake and degradation; MPS VII - Sly syndrome" "5" "0" "1.049" "1.010" "0.984" "1.032" "0.980" "1.044" "1.014" "0.915" "0.651" "354.4" "371.7" "358.0" "348.6" "365.6" "347.3" "369.9" "359.4" "324.4" "230.8" "" "" "" "" "" "" "" "" "" "" "187.7" "206.1" "205.0" "160.6" "197.8" "193.2" "217.7" "196.2" "182.0" "230.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2647028449518715682" "False" "High" "IsMasterProtein" "P16383" "Intron Large complex component GCFC2 OS=Homo sapiens OX=9606 GN=GCFC2 PE=1 SV=2" "0.000" "False" "10.308" "5" "4" "5" "4" "781" "89.3" "5.99" "14.91" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf07842" "6936" "ENSG00000005436" "GCFC2" "A4UHQ8; A4UHQ9; hsa:6936; O95032; P16383; Q53TY0; Q6P2F2" "" "mRNA Splicing - Major Pathway" "1" "0" "0.957" "1.071" "1.048" "0.845" "0.906" "0.888" "1.062" "1.005" "1.034" "108.2" "103.5" "115.8" "113.4" "91.4" "98.0" "96.0" "114.9" "108.8" "111.8" "" "" "" "" "" "" "" "" "" "" "57.3" "57.4" "66.3" "52.2" "49.4" "54.5" "56.5" "62.7" "61.0" "111.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2957906910240928632" "False" "High" "IsMasterProtein" "P22033" "Methylmalonyl-CoA mutase, mitochondrial OS=Homo sapiens OX=9606 GN=MMUT PE=1 SV=4" "0.000" "False" "10.306" "4" "3" "4" "3" "750" "83.1" "6.93" "8.85" "3" "other metabolic processes;developmental processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf01642, Pf02310" "4594" "ENSG00000146085" "MMUT" "A8K953; hsa:4594; P22033; Q5SYZ3; Q96B11; Q9UD64" "Vitamin B12 metabolism; Amino acid metabolism" "Propionyl-CoA catabolism; Defective MMAA causes MMA, cblA type; Defective MUT causes MMAM; Cobalamin (Cbl) metabolism" "6" "0" "0.990" "0.934" "1.135" "0.903" "0.878" "1.022" "0.768" "0.892" "1.239" "80.6" "79.7" "75.3" "91.5" "72.7" "70.8" "82.3" "61.8" "71.9" "99.9" "" "" "" "" "" "" "" "" "" "" "42.7" "44.2" "43.1" "42.1" "39.3" "39.4" "48.4" "33.8" "40.3" "99.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9004188409903141881" "False" "High" "IsMasterProtein" "P52758" "2-iminobutanoate/2-iminopropanoate deaminase OS=Homo sapiens OX=9606 GN=RIDA PE=1 SV=1" "0.000" "False" "10.301" "19" "2" "3" "2" "137" "14.5" "8.68" "8.06" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01042" "10247" "ENSG00000132541" "RIDA" "hsa:10247; P52758; Q6FHU9; Q6IBG0" "" "Threonine catabolism" "1" "0" "0.963" "0.994" "1.053" "1.046" "0.985" "0.974" "1.082" "0.972" "0.526" "330.1" "317.7" "328.2" "347.7" "345.2" "325.3" "321.4" "357.3" "320.8" "173.6" "" "" "" "" "" "" "" "" "" "" "174.8" "176.2" "188.0" "160.1" "186.7" "180.9" "189.1" "195.0" "180.0" "173.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8229141518412539790" "False" "High" "IsMasterProtein" "P68036" "Ubiquitin-conjugating enzyme E2 L3 OS=Homo sapiens OX=9606 GN=UBE2L3 PE=1 SV=1" "0.000" "False" "10.294" "16" "3" "7" "3" "154" "17.9" "8.51" "19.50" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00179" "7332" "ENSG00000185651" "UBE2L3" "B2R4A7; B4DDG1; B4DSZ4; E7EWS7; hsa:7332; P51966; P68036; P70653; Q9HAV1" "Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; Regulation of necroptotic cell death; Regulation of TNFR1 signaling" "7" "0" "1.014" "1.079" "0.907" "0.937" "0.862" "0.972" "1.075" "0.997" "0.486" "1347.2" "1366.3" "1453.9" "1221.3" "1261.8" "1161.1" "1308.8" "1448.2" "1343.6" "655.2" "" "" "" "" "" "" "" "" "" "" "713.3" "757.5" "832.6" "562.4" "682.7" "645.9" "770.3" "790.5" "753.7" "655.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2447610796588384838" "False" "High" "IsMasterProtein" "Q96SZ5" "2-aminoethanethiol dioxygenase OS=Homo sapiens OX=9606 GN=ADO PE=1 SV=2" "0.000" "False" "10.294" "13" "4" "6" "4" "270" "29.7" "6.04" "11.98" "4" "stress response" "cytosol" "other molecular function" "Pf07847" "84890" "ENSG00000181915" "ADO" "B1AL29; hsa:84890; Q96SZ5" "" "Degradation of cysteine and homocysteine" "1" "0" "1.012" "1.000" "1.052" "1.041" "1.004" "0.993" "1.016" "0.904" "0.872" "563.5" "570.5" "563.6" "592.6" "586.8" "565.8" "559.7" "572.5" "509.2" "491.2" "" "" "" "" "" "" "" "" "" "" "298.4" "316.3" "322.8" "272.9" "317.5" "314.7" "329.4" "312.5" "285.6" "491.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-445851658510322323" "False" "High" "IsMasterProtein" "P55769" "NHP2-like protein 1 OS=Homo sapiens OX=9606 GN=SNU13 PE=1 SV=3" "0.000" "False" "10.292" "21" "3" "4" "3" "128" "14.2" "8.46" "13.21" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01248" "4809" "ENSG00000100138" "SNU13" "hsa:4809; P55769" "mRNA processing" "mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8461791288305677895" "False" "High" "IsMasterProtein" "Q92783" "Signal transducing adapter molecule 1 OS=Homo sapiens OX=9606 GN=STAM PE=1 SV=3" "0.000" "False" "10.291" "6" "3" "3" "3" "540" "59.1" "4.82" "8.73" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00790, Pf02809" "8027" "ENSG00000136738" "STAM" "B0YJ99; D3DRU5; hsa:8027; Q8N6D9; Q92783" "Vitamin D receptor pathway; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway" "Cargo recognition for clathrin-mediated endocytosis; Endosomal Sorting Complex Required For Transport (ESCRT); RHOU GTPase cycle; Metalloprotease DUBs; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8330278091767700695" "False" "High" "IsMasterProtein" "Q6PCB5" "Lysine-specific demethylase RSBN1L OS=Homo sapiens OX=9606 GN=RSBN1L PE=1 SV=2" "0.000" "False" "10.280" "3" "3" "4" "3" "846" "94.8" "8.78" "11.13" "3" "" "nucleus" "other molecular function" "" "222194" "ENSG00000187257" "RSBN1L" "C9K0P1; hsa:222194; Q6PCB5; Q6ZS58; Q6ZVI9; Q86X48" "" "" "0" "0" "1.085" "0.922" "1.117" "1.107" "1.107" "1.113" "1.110" "1.030" "0.911" "195.0" "211.7" "179.9" "217.9" "216.0" "216.0" "217.0" "216.6" "200.9" "177.7" "" "" "" "" "" "" "" "" "" "" "103.3" "117.4" "103.0" "100.4" "116.8" "120.1" "127.7" "118.2" "112.7" "177.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3673508278002205446" "False" "High" "IsMasterProtein" "P36542" "ATP synthase subunit gamma, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1C PE=1 SV=1" "0.000" "False" "10.279" "11" "3" "3" "3" "298" "33.0" "9.22" "7.04" "3" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf00231" "509" "ENSG00000165629" "ATP5F1C" "A8KA31; hsa:509; P36542; Q5VYP3; Q6I9V2; Q96AS8" "Electron transport chain: OXPHOS system in mitochondria" "Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "4" "0" "0.941" "0.960" "0.969" "0.916" "0.966" "0.930" "0.846" "0.952" "1.123" "153.9" "144.8" "147.7" "149.0" "140.9" "148.7" "143.1" "130.2" "146.4" "172.8" "" "" "" "" "" "" "" "" "" "" "81.5" "80.3" "84.6" "68.6" "76.3" "82.7" "84.2" "71.1" "82.2" "172.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2021642276248058836" "False" "High" "IsMasterProtein" "Q8TD30" "Alanine aminotransferase 2 OS=Homo sapiens OX=9606 GN=GPT2 PE=1 SV=1" "0.000" "False" "10.271" "10" "4" "5" "4" "523" "57.9" "7.71" "9.36" "4" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00155" "84706" "ENSG00000166123" "GPT2" "hsa:84706; Q8N9E2; Q8TD30" "Amino acid metabolism; Amino acid metabolism pathway excerpt: histidine catabolism extension" "" "2" "0" "1.439" "0.913" "1.413" "1.521" "1.133" "1.136" "0.856" "0.980" "2.315" "43.3" "62.4" "39.6" "61.3" "65.9" "49.1" "49.2" "37.1" "42.5" "100.3" "" "" "" "" "" "" "" "" "" "" "23.0" "34.6" "22.7" "28.2" "35.7" "27.3" "29.0" "20.3" "23.8" "100.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5762043181650020657" "False" "High" "IsMasterProtein" "P46109" "Crk-like protein OS=Homo sapiens OX=9606 GN=CRKL PE=1 SV=1" "0.000" "False" "10.268" "13" "3" "3" "3" "303" "33.8" "6.74" "7.21" "3" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00018, Pf07653" "1399" "ENSG00000099942" "CRKL" "A8KA44; D3DX35; hsa:1399; P46109" "Androgen receptor network in prostate cancer; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; MAPK signaling pathway; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; EGF/EGFR signaling pathway; 22q11.2 copy number variation syndrome; IL-2 signaling pathway; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor signaling pathway" "Downstream signal transduction; Regulation of signaling by CBL; Erythropoietin activates RAS; Frs2-mediated activation; MET activates RAP1 and RAC1; MET receptor recycling" "22" "0" "0.995" "1.016" "1.154" "1.118" "1.113" "1.001" "1.049" "1.190" "1.419" "167.4" "166.5" "170.0" "193.2" "187.1" "186.2" "167.5" "175.5" "199.1" "237.4" "" "" "" "" "" "" "" "" "" "" "88.6" "92.3" "97.4" "89.0" "101.3" "103.6" "98.6" "95.8" "111.7" "237.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7522921008615735421" "False" "High" "IsMasterProtein" "O75152" "Zinc finger CCCH domain-containing protein 11A OS=Homo sapiens OX=9606 GN=ZC3H11A PE=1 SV=3" "0.000" "False" "10.266" "4" "3" "3" "3" "810" "89.1" "8.37" "9.76" "3" "other metabolic processes;transport" "nucleus" "other molecular function" "Pf15663" "9877" "ENSG00000058673" "ZC3H11A" "hsa:9877; O75152; Q6AHY4; Q6AHY9; Q6AW79; Q6AWA1; Q6PJK4; Q86XZ7" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "0.845" "1.154" "1.106" "1.066" "1.008" "1.730" "1.495" "1.616" "3.735" "42.1" "35.6" "48.6" "46.6" "44.9" "42.5" "72.9" "63.0" "68.1" "157.4" "" "" "" "" "" "" "" "" "" "" "22.3" "19.7" "27.9" "21.5" "24.3" "23.6" "42.9" "34.4" "38.2" "157.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8740975055967109676" "False" "High" "IsMasterProtein" "O95926" "Pre-mRNA-splicing factor SYF2 OS=Homo sapiens OX=9606 GN=SYF2 PE=1 SV=1" "0.000" "False" "10.252" "9" "2" "2" "2" "243" "28.7" "8.40" "8.21" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf08231" "25949" "ENSG00000117614" "SYF2" "hsa:25949; O95926; Q5TH73" "" "mRNA Splicing - Major Pathway" "1" "0" "1.089" "1.127" "1.167" "1.075" "0.944" "1.169" "1.339" "1.096" "0.512" "149.5" "162.8" "168.5" "174.5" "160.7" "141.2" "174.8" "200.2" "163.8" "76.6" "" "" "" "" "" "" "" "" "" "" "79.2" "90.3" "96.5" "80.4" "86.9" "78.5" "102.9" "109.3" "91.9" "76.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2594801350968766228" "False" "High" "IsMasterProtein" "Q99986" "Serine/threonine-protein kinase VRK1 OS=Homo sapiens OX=9606 GN=VRK1 PE=1 SV=1" "0.000" "False" "10.249" "9" "3" "4" "3" "396" "45.4" "8.91" "11.92" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus" "kinase activity;other molecular function" "Pf00069" "7443" "ENSG00000100749" "VRK1" "hsa:7443; Q3SYL2; Q99986" "" "Nuclear Envelope Breakdown; Initiation of Nuclear Envelope (NE) Reformation" "2" "0" "1.152" "1.144" "1.157" "1.035" "1.058" "0.911" "0.847" "1.076" "4.567" "109.8" "126.4" "125.6" "127.0" "113.6" "116.1" "100.0" "93.0" "118.1" "501.4" "" "" "" "" "" "" "" "" "" "" "58.1" "70.1" "71.9" "58.5" "61.5" "64.6" "58.8" "50.7" "66.2" "501.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-220085271204376127" "False" "High" "IsMasterProtein" "O95983" "Methyl-CpG-binding domain protein 3 OS=Homo sapiens OX=9606 GN=MBD3 PE=1 SV=1" "0.000" "False" "10.243" "13" "4" "5" "3" "291" "32.8" "5.34" "12.14" "4" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01429, Pf14048, Pf16564" "53615" "ENSG00000071655" "MBD3" "A8K4B7; D6W5Z2; hsa:53615; O95983; Q6PIL9; Q6PJZ9; Q86XF4" "Effect of progerin on genes involved in progeria" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "7" "0" "1.078" "0.948" "1.186" "1.079" "1.148" "1.309" "1.073" "1.244" "1.813" "101.9" "109.9" "96.6" "120.9" "110.0" "117.0" "133.5" "109.4" "126.8" "184.8" "" "" "" "" "" "" "" "" "" "" "54.0" "60.9" "55.3" "55.7" "59.5" "65.1" "78.6" "59.7" "71.1" "184.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1796554414882976290" "False" "High" "IsMasterProtein" "Q8TCG1" "Protein CIP2A OS=Homo sapiens OX=9606 GN=CIP2A PE=1 SV=2" "0.000" "False" "10.235" "4" "4" "4" "4" "905" "102.1" "6.23" "9.66" "4" "cell organization and biogenesis;stress response" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf21044" "57650" "ENSG00000163507" "CIP2A" "A1L4J7; B9EGC3; hsa:57650; Q6P4G6; Q8TCG1; Q8WVP8; Q96PI2; Q9H9C6; Q9P204" "Netrin-UNC5B signaling pathway" "" "1" "0" "0.945" "0.882" "0.995" "1.069" "0.871" "0.931" "0.527" "0.797" "5.585" "147.7" "139.6" "130.3" "146.9" "158.0" "128.6" "137.6" "77.8" "117.7" "825.0" "" "" "" "" "" "" "" "" "" "" "78.2" "77.4" "74.6" "67.7" "85.5" "71.5" "81.0" "42.5" "66.0" "825.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6808375425283248797" "False" "High" "IsMasterProtein" "Q13572" "Inositol-tetrakisphosphate 1-kinase OS=Homo sapiens OX=9606 GN=ITPK1 PE=1 SV=2" "0.000" "False" "10.234" "6" "2" "2" "2" "414" "45.6" "6.16" "7.61" "2" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "kinase activity;other molecular function" "Pf05770, Pf17927" "3705" "ENSG00000100605; ENSG00000274958" "ITPK1" "hsa:3705; Q13572; Q9BTL6; Q9H2E7" "2q37 copy number variation syndrome" "Factors involved in megakaryocyte development and platelet production; Synthesis of IP3 and IP4 in the cytosol; Synthesis of pyrophosphates in the cytosol" "4" "0" "1.107" "1.032" "1.066" "1.026" "1.037" "1.018" "0.906" "0.956" "1.417" "303.4" "335.9" "313.1" "323.6" "311.3" "314.8" "309.0" "275.0" "290.0" "430.1" "" "" "" "" "" "" "" "" "" "" "160.7" "186.3" "179.3" "149.0" "168.4" "175.1" "181.9" "150.1" "162.7" "430.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8718473415120973367" "False" "High" "IsMasterProtein" "O00462" "Beta-mannosidase OS=Homo sapiens OX=9606 GN=MANBA PE=1 SV=3" "0.000" "False" "10.200" "4" "4" "6" "3" "879" "100.8" "5.52" "17.38" "4" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;other cytoplasmic organelle" "other molecular function" "Pf02836, Pf17753, Pf17786" "4126" "ENSG00000109323" "MANBA" "hsa:4126; O00462; Q96BC3; Q9NYX9" "" "Neutrophil degranulation; Lysosomal oligosaccharide catabolism" "2" "0" "0.938" "0.902" "0.886" "0.934" "0.988" "0.922" "0.905" "0.881" "0.541" "246.8" "231.4" "222.5" "218.7" "230.4" "243.7" "227.4" "223.2" "217.4" "133.5" "" "" "" "" "" "" "" "" "" "" "130.7" "128.3" "127.4" "100.7" "124.6" "135.6" "133.8" "121.9" "122.0" "133.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "718795190937465911" "False" "High" "IsMasterProtein" "Q9Y6V7" "Probable ATP-dependent RNA helicase DDX49 OS=Homo sapiens OX=9606 GN=DDX49 PE=1 SV=1" "0.000" "False" "10.196" "5" "3" "3" "3" "483" "54.2" "9.06" "9.11" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00270, Pf00271" "54555" "ENSG00000105671" "DDX49" "E7ENA0; hsa:54555; Q53FJ1; Q9BVQ8; Q9Y6V7" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.087" "1.021" "1.285" "1.045" "0.985" "0.987" "0.966" "0.935" "0.879" "382.5" "415.7" "390.6" "491.7" "399.8" "376.7" "377.5" "369.7" "357.5" "336.1" "" "" "" "" "" "" "" "" "" "" "202.5" "230.5" "223.7" "226.4" "216.3" "209.5" "222.2" "201.8" "200.6" "336.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4893836570063627970" "False" "High" "IsMasterProtein" "O75494" "Serine/arginine-rich splicing factor 10 OS=Homo sapiens OX=9606 GN=SRSF10 PE=1 SV=1" "0.000" "False" "10.173" "8" "2" "2" "2" "262" "31.3" "11.27" "6.03" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "10772" "ENSG00000188529" "SRSF10" "A6NFM6; A6NI42; A6NIU7; B4DJP9; hsa:10772; O60572; O75494; Q5JRH9; Q5JRI0; Q5JRI2; Q5JRI3; Q5JRI4; Q96G09; Q96P17" "mRNA processing" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "3" "0" "1.113" "1.027" "1.065" "1.018" "0.937" "1.136" "1.151" "1.034" "0.862" "178.2" "198.4" "183.0" "189.8" "181.4" "167.0" "202.5" "205.2" "184.3" "153.6" "" "" "" "" "" "" "" "" "" "" "94.4" "110.0" "104.8" "87.4" "98.2" "92.9" "119.2" "112.0" "103.4" "153.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1075701088619798442" "False" "High" "IsMasterProtein" "Q96BZ8" "Leukocyte receptor cluster member 1 OS=Homo sapiens OX=9606 GN=LENG1 PE=1 SV=2" "0.000" "False" "10.166" "9" "3" "4" "3" "264" "30.5" "9.80" "12.63" "3" "" "nucleus" "" "Pf10197" "79165" "ENSG00000105617; ENSG00000275935; ENSG00000276628; ENSG00000276774; ENSG00000276959; ENSG00000277457; ENSG00000277808; ENSG00000278257; ENSG00000278426; ENSG00000278516" "LENG1" "hsa:79165; Q96BZ8; Q9HCU7" "" "mRNA Splicing - Major Pathway" "1" "0" "1.063" "1.156" "1.140" "1.041" "1.078" "1.099" "1.118" "1.057" "0.617" "574.7" "610.8" "664.5" "655.4" "598.1" "619.4" "631.4" "642.4" "607.4" "354.4" "" "" "" "" "" "" "" "" "" "" "304.3" "338.6" "380.6" "301.8" "323.6" "344.5" "371.6" "350.6" "340.7" "354.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4563498728879559184" "False" "High" "IsMasterProtein" "Q9BW71" "HIRA-interacting protein 3 OS=Homo sapiens OX=9606 GN=HIRIP3 PE=1 SV=3" "0.000" "False" "10.160" "6" "4" "4" "4" "556" "61.9" "8.54" "9.86" "4" "cell organization and biogenesis" "nucleus" "" "Pf09649" "8479" "ENSG00000149929" "HIRIP3" "H3BSR3; hsa:8479; O75707; O75708; Q9BW71" "22q11.2 copy number variation syndrome; 16p11.2 proximal deletion syndrome" "" "2" "0" "1.055" "1.103" "1.089" "1.093" "1.058" "1.494" "1.506" "1.412" "0.797" "267.9" "282.6" "295.5" "291.6" "292.9" "283.4" "400.3" "403.6" "378.3" "213.5" "" "" "" "" "" "" "" "" "" "" "141.9" "156.7" "169.2" "134.3" "158.5" "157.6" "235.6" "220.3" "212.2" "213.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4577230366185343110" "False" "High" "IsMasterProtein" "Q96GM8" "Target of EGR1 protein 1 OS=Homo sapiens OX=9606 GN=TOE1 PE=1 SV=1" "0.000" "False" "10.156" "5" "3" "4" "3" "510" "56.5" "7.18" "12.08" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf04857" "114034" "ENSG00000132773" "TOE1" "B4DEM6; hsa:114034; Q6IA35; Q8IWN5; Q96GM8; Q9H846" "" "" "0" "0" "1.060" "1.021" "1.186" "1.138" "1.149" "1.238" "1.161" "1.153" "0.730" "341.0" "361.6" "348.2" "404.5" "387.9" "391.9" "422.0" "395.9" "393.2" "248.8" "" "" "" "" "" "" "" "" "" "" "180.6" "200.5" "199.4" "186.3" "209.9" "218.0" "248.3" "216.1" "220.6" "248.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4232598259152992278" "False" "High" "IsMasterProtein" "Q86Y56" "Dynein axonemal assembly factor 5 OS=Homo sapiens OX=9606 GN=DNAAF5 PE=1 SV=4" "0.000" "False" "10.155" "5" "5" "6" "5" "855" "93.5" "6.42" "12.36" "5" "cell organization and biogenesis;other biological processes" "other cell component" "other molecular function" "Pf02985" "54919" "ENSG00000164818" "DNAAF5" "hsa:54919; Q69YL1; Q86Y56; Q96FI9; Q9NX75" "Ciliopathies" "" "1" "0" "0.973" "1.077" "1.064" "0.950" "1.021" "0.958" "0.695" "0.891" "4.902" "285.4" "277.7" "307.5" "303.8" "271.1" "291.4" "273.5" "198.3" "254.3" "1399.3" "" "" "" "" "" "" "" "" "" "" "151.1" "154.0" "176.1" "139.9" "146.7" "162.1" "161.0" "108.2" "142.6" "1399.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6713269859164182683" "False" "High" "IsMasterProtein" "P08567" "Pleckstrin OS=Homo sapiens OX=9606 GN=PLEK PE=1 SV=3" "0.000" "False" "10.139" "8" "2" "3" "2" "350" "40.1" "8.28" "11.13" "2" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00169, Pf00610" "5341" "ENSG00000115956" "PLEK" "B2R9E8; hsa:5341; P08567; Q53SU8; Q6FGM8; Q6FGQ1; Q8WV81" "Serotonin and anxiety-related events; TYROBP causal network in microglia; Serotonin and anxiety" "Platelet degranulation" "4" "0" "1.160" "1.131" "1.276" "1.204" "1.249" "1.272" "0.934" "1.148" "1.571" "63.0" "73.1" "71.3" "80.4" "75.8" "78.7" "80.2" "58.9" "72.4" "99.0" "" "" "" "" "" "" "" "" "" "" "33.4" "40.5" "40.8" "37.0" "41.0" "43.8" "47.2" "32.1" "40.6" "99.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2292593222020041360" "False" "High" "IsMasterProtein" "Q92925" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 OS=Homo sapiens OX=9606 GN=SMARCD2 PE=1 SV=3" "0.000" "False" "10.139" "4" "2" "4" "2" "531" "58.9" "9.64" "11.00" "2" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02201" "6603" "ENSG00000108604" "SMARCD2" "A5PLL5; A6NNQ7; B4DV56; B4E1R6; hsa:6603; Q7L2I6; Q92925; Q9UHZ1" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "6" "0" "1.002" "1.119" "1.078" "1.028" "0.956" "1.008" "0.445" "1.086" "7.216" "139.7" "140.0" "156.3" "150.6" "143.6" "133.5" "140.8" "62.2" "151.7" "1007.9" "" "" "" "" "" "" "" "" "" "" "74.0" "77.6" "89.5" "69.4" "77.7" "74.2" "82.9" "33.9" "85.1" "1007.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4518403686067478951" "False" "High" "IsMasterProtein" "O95149" "Snurportin-1 OS=Homo sapiens OX=9606 GN=SNUPN PE=1 SV=1" "0.000" "False" "10.138" "8" "3" "4" "3" "360" "41.1" "6.64" "8.91" "3" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11538" "10073" "ENSG00000169371" "SNUPN" "A6NE34; A8K0B0; D3DW76; hsa:10073; O95149" "" "snRNP Assembly" "1" "0" "0.990" "0.987" "1.096" "1.037" "1.105" "1.009" "0.856" "1.013" "1.862" "252.5" "249.9" "249.3" "276.6" "261.9" "279.0" "254.6" "216.2" "255.7" "470.0" "" "" "" "" "" "" "" "" "" "" "133.7" "138.5" "142.8" "127.4" "141.7" "155.2" "149.8" "118.0" "143.4" "470.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2098721597077854322" "False" "High" "IsMasterProtein" "Q9NTJ4" "Alpha-mannosidase 2C1 OS=Homo sapiens OX=9606 GN=MAN2C1 PE=1 SV=1" "0.000" "False" "10.117" "3" "3" "3" "3" "1040" "115.8" "6.57" "7.80" "3" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01074, Pf07748, Pf09261, Pf17677" "4123" "ENSG00000140400" "MAN2C1" "H3BMX2; H3BQY8; H3BUT6; hsa:4123; Q13358; Q68EM8; Q9NTJ4; Q9UL64" "" "Lysosomal oligosaccharide catabolism" "1" "0" "0.859" "0.942" "0.947" "0.872" "1.045" "0.973" "1.026" "1.066" "0.653" "141.1" "121.2" "132.9" "133.6" "123.0" "147.5" "137.3" "144.8" "150.3" "92.1" "" "" "" "" "" "" "" "" "" "" "74.7" "67.2" "76.1" "61.5" "66.6" "82.0" "80.8" "79.0" "84.3" "92.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "672780113730382771" "False" "High" "IsMasterProtein" "Q99952" "Tyrosine-protein phosphatase non-receptor type 18 OS=Homo sapiens OX=9606 GN=PTPN18 PE=1 SV=2" "0.000" "False" "10.116" "5" "1" "1" "1" "460" "50.5" "8.25" "5.36" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00102" "26469" "ENSG00000072135" "PTPN18" "B4E1E6; hsa:26469; Q53P42; Q99952" "B cell receptor signaling pathway" "Downregulation of ERBB2 signaling; Interleukin-37 signaling" "3" "0" "1.032" "1.258" "1.078" "0.866" "0.893" "0.965" "0.892" "0.800" "0.742" "45.8" "47.2" "57.6" "49.3" "39.6" "40.8" "44.2" "40.8" "36.6" "33.9" "" "" "" "" "" "" "" "" "" "" "24.2" "26.2" "33.0" "22.7" "21.4" "22.7" "26.0" "22.3" "20.5" "33.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4459716120349710015" "False" "High" "IsMasterProtein" "O14545" "TRAF-type zinc finger domain-containing protein 1 OS=Homo sapiens OX=9606 GN=TRAFD1 PE=1 SV=1" "0.000" "False" "10.108" "4" "2" "2" "2" "582" "64.8" "5.29" "3.58" "2" "other biological processes" "mitochondrion" "other molecular function" "Pf21366" "10906" "ENSG00000135148" "TRAFD1" "A8K5L6; B4DI89; hsa:10906; O14545" "" "" "0" "0" "1.086" "1.062" "1.108" "1.024" "1.058" "1.268" "1.244" "1.249" "0.726" "122.6" "133.2" "130.3" "135.8" "125.5" "129.7" "155.4" "152.6" "153.1" "89.0" "" "" "" "" "" "" "" "" "" "" "64.9" "73.8" "74.6" "62.5" "67.9" "72.1" "91.5" "83.3" "85.9" "89.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3533689105478908948" "False" "High" "IsMasterProtein" "Q15369" "Elongin-C OS=Homo sapiens OX=9606 GN=ELOC PE=1 SV=1" "0.000" "False" "10.091" "27" "2" "4" "2" "112" "12.5" "4.78" "12.94" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03931" "6921" "ENSG00000154582" "ELOC" "E5RGD9; hsa:6921; Q15369; Q567Q6" "Dual hijack model of Vif in HIV infection; VEGFA-VEGFR2 signaling; Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2" "Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Neddylation; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Inactivation of CSF3 (G-CSF) signaling; Evasion by RSV of host interferon responses" "22" "0" "1.006" "0.963" "0.939" "1.016" "0.831" "0.862" "0.968" "0.928" "1.358" "397.9" "400.5" "383.1" "373.7" "404.4" "330.6" "343.1" "385.1" "369.3" "540.4" "" "" "" "" "" "" "" "" "" "" "210.7" "222.0" "219.4" "172.1" "218.8" "183.9" "201.9" "210.2" "207.1" "540.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1787588940823929001" "False" "High" "IsMasterProtein" "P61224" "Ras-related protein Rap-1b OS=Homo sapiens OX=9606 GN=RAP1B PE=1 SV=1" "0.000" "False" "10.076" "17" "3" "5" "3" "184" "20.8" "5.78" "13.18" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5908" "ENSG00000127314" "RAP1B" "B2R5Z2; B4DQI8; B4DW74; B4DW94; hsa:5908; P09526; P61224; Q502X3; Q5TZR4; Q6DCA1; Q6LES0" "Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Androgen receptor network in prostate cancer; Corticotropin-releasing hormone signaling pathway; Common pathways underlying drug addiction; Focal adhesion; Hepatocyte growth factor receptor signaling; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; Ras signaling" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Rap1 signalling; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; MET activates RAP1 and RAC1" "26" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "215729870143927910" "False" "High" "IsMasterProtein" "P52815" "Large ribosomal subunit protein bL12m OS=Homo sapiens OX=9606 GN=MRPL12 PE=1 SV=2" "0.000" "False" "10.076" "13" "2" "3" "2" "198" "21.3" "8.87" "7.14" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00542, Pf16320" "6182" "ENSG00000262814" "MRPL12" "hsa:6182; P52815; Q969U0; Q9HCA2; Q9UQJ3" "" "Mitochondrial protein degradation; Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "1.253" "0.893" "0.859" "1.020" "1.263" "0.940" "0.992" "0.874" "0.744" "43.1" "53.9" "38.4" "37.0" "43.9" "54.4" "40.5" "42.7" "37.6" "32.0" "" "" "" "" "" "" "" "" "" "" "22.8" "29.9" "22.0" "17.0" "23.8" "30.2" "23.8" "23.3" "21.1" "32.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4271689599031996441" "False" "High" "IsMasterProtein" "Q9H1K1" "Iron-sulfur cluster assembly enzyme ISCU OS=Homo sapiens OX=9606 GN=ISCU PE=1 SV=2" "0.000" "False" "10.075" "15" "3" "4" "3" "167" "18.0" "9.48" "12.68" "3" "cell organization and biogenesis;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01592" "23479" "ENSG00000136003" "ISCU" "hsa:23479; Q6P713; Q99617; Q9H1K1; Q9H1K2" "Iron-sulfur cluster biogenesis" "Maturation of replicase proteins" "2" "0" "0.865" "0.896" "0.902" "0.856" "0.940" "0.834" "0.912" "0.803" "0.476" "1334.1" "1153.9" "1195.9" "1203.2" "1141.4" "1253.4" "1113.1" "1216.1" "1071.3" "635.2" "" "" "" "" "" "" "" "" "" "" "706.4" "639.7" "684.9" "554.1" "617.5" "697.2" "655.1" "663.8" "601.0" "635.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1741293636862823993" "False" "High" "IsMasterProtein" "Q5T1M5" "FK506-binding protein 15 OS=Homo sapiens OX=9606 GN=FKBP15 PE=1 SV=2" "0.000" "False" "10.073" "3" "4" "4" "4" "1219" "133.5" "5.20" "8.28" "4" "transport" "other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00254" "23307" "ENSG00000119321" "FKBP15" "hsa:23307; Q05DK8; Q5T1M2; Q5T1M5; Q6DD85; Q9Y4D0" "TYROBP causal network in microglia" "" "1" "0" "0.975" "1.130" "1.245" "1.144" "1.162" "1.456" "1.453" "1.334" "2.349" "168.8" "164.5" "190.7" "210.2" "193.0" "196.1" "245.8" "245.3" "225.1" "396.4" "" "" "" "" "" "" "" "" "" "" "89.4" "91.2" "109.2" "96.8" "104.4" "109.1" "144.7" "133.9" "126.3" "396.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6962760823323839829" "False" "High" "IsMasterProtein" "O43681" "ATPase GET3 OS=Homo sapiens OX=9606 GN=GET3 PE=1 SV=2" "0.000" "False" "10.063" "7" "3" "3" "3" "348" "38.8" "4.91" "9.96" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf02374" "439" "ENSG00000198356" "GET3" "A6NHP8; A8K740; hsa:439; O43681; Q53FC6; Q92849" "" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "1" "0" "0.999" "0.965" "0.888" "0.961" "0.937" "0.885" "0.842" "0.884" "0.639" "859.8" "859.3" "829.5" "763.3" "826.6" "805.2" "761.2" "723.6" "760.3" "549.0" "" "" "" "" "" "" "" "" "" "" "455.2" "476.4" "475.0" "351.5" "447.2" "447.9" "448.0" "395.0" "426.5" "549.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5468856902780976606" "False" "High" "IsMasterProtein" "O60884" "DnaJ homolog subfamily A member 2 OS=Homo sapiens OX=9606 GN=DNAJA2 PE=1 SV=1" "0.000" "False" "10.062" "9" "4" "5" "4" "412" "45.7" "6.48" "13.30" "4" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;other cell component" "other molecular function" "Pf00226, Pf00684, Pf01556" "10294" "ENSG00000069345" "DNAJA2" "B2R7L7; hsa:10294; O14711; O60884" "" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" "1" "0" "1.078" "1.045" "1.168" "1.140" "1.236" "1.063" "0.960" "1.079" "2.651" "240.4" "259.3" "251.1" "280.7" "274.1" "297.1" "255.6" "230.7" "259.4" "637.5" "" "" "" "" "" "" "" "" "" "" "127.3" "143.7" "143.8" "129.3" "148.3" "165.3" "150.4" "125.9" "145.5" "637.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6107269265140402008" "False" "High" "IsMasterProtein" "P10109" "Adrenodoxin, mitochondrial OS=Homo sapiens OX=9606 GN=FDX1 PE=1 SV=1" "0.000" "False" "10.060" "13" "3" "3" "3" "184" "19.4" "5.83" "10.31" "3" "other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf00111" "2230" "ENSG00000137714" "FDX1" "B0YJ14; hsa:2230; P10109; Q53YD6" "Iron-sulfur cluster biogenesis" "Endogenous sterols; Pregnenolone biosynthesis; Defective CYP11A1 causes AICSR; Electron transport from NADPH to Ferredoxin" "6" "0" "1.014" "1.023" "0.850" "1.008" "0.877" "0.880" "1.009" "0.890" "0.502" "1186.6" "1202.8" "1213.3" "1008.6" "1195.6" "1040.5" "1043.9" "1197.2" "1055.7" "595.7" "" "" "" "" "" "" "" "" "" "" "628.3" "666.8" "694.9" "464.5" "646.8" "578.8" "614.4" "653.5" "592.2" "595.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7880237521652408093" "False" "High" "IsMasterProtein" "P15408" "Fos-related antigen 2 OS=Homo sapiens OX=9606 GN=FOSL2 PE=1 SV=1" "0.000" "False" "10.058" "8" "2" "2" "2" "326" "35.2" "7.49" "5.97" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "2355" "ENSG00000075426" "FOSL2" "B2RD58; B3KP27; B4DYV4; hsa:2355; P15408; Q6FG46" "Corticotropin-releasing hormone signaling pathway; Orexin receptor pathway; Osteoarthritic chondrocyte hypertrophy" "" "3" "0" "1.048" "1.028" "1.132" "1.032" "0.987" "1.002" "1.095" "0.999" "0.657" "182.2" "190.9" "187.3" "206.3" "188.1" "180.0" "182.6" "199.5" "182.1" "119.7" "" "" "" "" "" "" "" "" "" "" "96.5" "105.8" "107.3" "95.0" "101.8" "100.1" "107.5" "108.9" "102.1" "119.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3564377166653415060" "False" "High" "IsMasterProtein" "Q5JS54" "Proteasome assembly chaperone 4 OS=Homo sapiens OX=9606 GN=PSMG4 PE=1 SV=2" "0.000" "False" "10.047" "20" "1" "1" "1" "123" "13.8" "6.52" "5.38" "1" "cell organization and biogenesis" "other cell component" "other molecular function" "Pf16093" "389362" "ENSG00000180822" "PSMG4" "C9J2F8; F8WBZ2; hsa:389362; Q5JS53; Q5JS54; Q5JS56" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-708383096801431027" "False" "High" "IsMasterProtein" "Q9HD34" "LYR motif-containing protein 4 OS=Homo sapiens OX=9606 GN=LYRM4 PE=1 SV=1" "0.000" "False" "10.024" "20" "2" "5" "2" "91" "10.8" "10.73" "11.10" "2" "cell organization and biogenesis" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf05347" "57128" "ENSG00000214113" "LYRM4" "A8K543; hsa:57128; Q5XKP1; Q9HD34" "Iron-sulfur cluster biogenesis" "Mitochondrial iron-sulfur cluster biogenesis" "2" "0" "0.871" "0.962" "0.677" "0.615" "0.654" "1.074" "0.738" "0.683" "0.348" "148.1" "129.0" "142.5" "100.3" "91.0" "96.9" "159.0" "109.2" "101.1" "51.5" "" "" "" "" "" "" "" "" "" "" "78.4" "71.5" "81.6" "46.2" "49.2" "53.9" "93.6" "59.6" "56.7" "51.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-255680334974208161" "False" "High" "IsMasterProtein" "Q9Y4K4" "Mitogen-activated protein kinase kinase kinase kinase 5 OS=Homo sapiens OX=9606 GN=MAP4K5 PE=1 SV=3" "0.000" "False" "10.022" "4" "3" "3" "3" "846" "95.0" "7.72" "7.51" "3" "other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol" "kinase activity;other molecular function" "Pf00069, Pf00780" "11183" "ENSG00000012983" "MAP4K5" "A0A804HIS2; hsa:11183" "Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Insulin signaling" "" "3" "0" "0.996" "1.067" "0.978" "1.019" "1.069" "0.960" "0.947" "0.983" "0.959" "190.8" "190.0" "203.6" "186.7" "194.4" "204.1" "183.3" "180.8" "187.5" "182.9" "" "" "" "" "" "" "" "" "" "" "101.1" "105.3" "116.6" "86.0" "105.2" "113.5" "107.9" "98.7" "105.2" "182.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7242737941757580841" "False" "High" "IsMasterProtein" "P54105" "Methylosome subunit pICln OS=Homo sapiens OX=9606 GN=CLNS1A PE=1 SV=1" "0.000" "False" "10.015" "9" "1" "1" "1" "237" "26.2" "4.11" "4.79" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf03517" "1207" "ENSG00000074201" "CLNS1A" "B2RCS9; hsa:1207; P54105; Q0VDK6; Q9NRD2; Q9NRD3" "" "snRNP Assembly" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9028171991778450679" "False" "High" "IsMasterProtein" "P27540" "Aryl hydrocarbon receptor nuclear translocator OS=Homo sapiens OX=9606 GN=ARNT PE=1 SV=1" "0.000" "False" "10.007" "3" "2" "2" "2" "789" "86.6" "6.54" "6.47" "2" "stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00010, Pf00989, Pf14598" "405" "ENSG00000143437" "ARNT" "B2R9H1; C4AMA1; F8WAP6; hsa:405; P27540; Q59ED4; Q5QP39; Q8NDC7" "Angiogenesis; Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Type 2 papillary renal cell carcinoma; 6q16 copy number variation" "PPARA activates gene expression; NPAS4 regulates expression of target genes; Endogenous sterols; Xenobiotics; Aryl hydrocarbon receptor signalling; Regulation of gene expression by Hypoxia-inducible Factor" "16" "0" "0.814" "0.850" "1.061" "1.028" "0.911" "1.079" "1.119" "1.144" "1.259" "198.3" "161.4" "168.6" "210.4" "203.8" "180.6" "214.1" "221.8" "227.0" "249.6" "" "" "" "" "" "" "" "" "" "" "105.0" "89.5" "96.6" "96.9" "110.3" "100.5" "126.0" "121.1" "127.3" "249.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4286201540320348411" "False" "High" "IsMasterProtein" "Q92990" "Glomulin OS=Homo sapiens OX=9606 GN=GLMN PE=1 SV=2" "0.000" "False" "9.972" "3" "2" "2" "2" "594" "68.2" "5.33" "6.88" "2" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf08568" "11146" "ENSG00000174842" "GLMN" "hsa:11146; Q5VVC3; Q92990; Q9BVE8" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.116" "1.057" "0.932" "1.066" "1.144" "0.935" "0.898" "0.988" "1.772" "222.4" "248.1" "235.0" "207.2" "237.1" "254.4" "208.0" "199.6" "219.6" "394.1" "" "" "" "" "" "" "" "" "" "" "117.7" "137.6" "134.6" "95.4" "128.3" "141.5" "122.4" "108.9" "123.2" "394.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2604748441743257015" "False" "High" "IsMasterProtein" "Q6P1J9" "Parafibromin OS=Homo sapiens OX=9606 GN=CDC73 PE=1 SV=1" "0.000" "False" "9.944" "5" "3" "3" "3" "531" "60.5" "9.61" "8.88" "3" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf05179, Pf16050" "79577" "ENSG00000134371" "CDC73" "A6NLZ8; B2RBR2; hsa:79577; Q6P1J9; Q6PK51; Q96A07; Q9H245; Q9H5L7" "Endoderm differentiation" "Hedgehog 'on' state; RNA Polymerase II Pre-transcription Events; Formation of the beta-catenin:TCF transactivating complex; E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex" "7" "0" "0.926" "1.089" "1.143" "1.086" "0.967" "1.278" "1.018" "1.226" "3.022" "193.5" "179.1" "210.7" "221.0" "210.1" "187.0" "247.2" "196.9" "237.3" "584.6" "" "" "" "" "" "" "" "" "" "" "102.4" "99.3" "120.7" "101.8" "113.7" "104.0" "145.5" "107.5" "133.1" "584.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5005223025872710581" "False" "High" "IsMasterProtein" "O60524" "Ribosome quality control complex subunit NEMF OS=Homo sapiens OX=9606 GN=NEMF PE=1 SV=4" "0.000" "False" "9.930" "3" "4" "6" "4" "1076" "122.9" "6.35" "9.82" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "cytosol;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf05670, Pf05833, Pf11923" "9147" "ENSG00000165525" "NEMF" "A0JLQ3; B3KSK1; B4DDL3; B4DHA9; B4E3F3; hsa:9147; O60524; Q32Q66; Q8WW70; Q9NWG1" "" "" "0" "0" "1.197" "1.057" "1.276" "1.142" "1.085" "1.158" "0.973" "1.003" "1.493" "298.2" "356.8" "315.0" "380.5" "340.5" "323.4" "345.2" "290.2" "299.2" "445.3" "" "" "" "" "" "" "" "" "" "" "157.9" "197.8" "180.4" "175.2" "184.2" "179.9" "203.2" "158.4" "167.8" "445.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3452513591771994158" "False" "High" "IsMasterProtein" "Q6ICG6" "Uncharacterized protein KIAA0930 OS=Homo sapiens OX=9606 GN=KIAA0930 PE=1 SV=1" "0.000" "False" "9.925" "8" "3" "4" "3" "404" "45.8" "7.94" "5.56" "3" "" "" "" "Pf09741" "23313" "ENSG00000100364" "KIAA0930" "B0QY17; B0QY19; B3KT48; hsa:23313; Q6ICG6; Q6ZVE5; Q7Z6K9; Q8IZ76; Q9Y2E2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5375440904508103637" "False" "High" "IsMasterProtein" "Q6ZSJ8" "Uncharacterized protein C1orf122 OS=Homo sapiens OX=9606 GN=C1orf122 PE=1 SV=2" "0.000" "False" "9.924" "18" "2" "3" "2" "110" "11.5" "6.73" "9.07" "2" "" "" "" "Pf15855" "127687" "ENSG00000197982" "C1orf122" "A2RQF4; E9PQ13; hsa:127687; Q56A71; Q6ZSJ8" "" "" "0" "0" "1.102" "1.249" "1.306" "1.229" "1.092" "1.141" "1.160" "1.093" "1.021" "181.4" "200.0" "226.6" "237.0" "223.0" "198.2" "207.0" "210.4" "198.3" "185.1" "" "" "" "" "" "" "" "" "" "" "96.1" "110.9" "129.8" "109.1" "120.7" "110.2" "121.8" "114.8" "111.2" "185.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6299048692266605018" "False" "High" "IsMasterProtein" "Q14161" "ARF GTPase-activating protein GIT2 OS=Homo sapiens OX=9606 GN=GIT2 PE=1 SV=2" "0.000" "False" "9.908" "4" "3" "3" "2" "759" "84.5" "7.23" "8.34" "3" "transport;developmental processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00023, Pf01412, Pf08518, Pf12205, Pf16559" "9815" "ENSG00000139436" "GIT2" "hsa:9815; Q14161; Q86U59; Q96CI2; Q9BV91; Q9Y5V2" "Integrin-mediated cell adhesion" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle" "9" "0" "0.896" "0.918" "1.022" "1.103" "1.180" "1.270" "0.874" "1.207" "6.354" "102.5" "91.8" "94.1" "104.7" "113.0" "120.9" "130.1" "89.5" "123.7" "651.0" "" "" "" "" "" "" "" "" "" "" "54.2" "50.9" "53.9" "48.2" "61.1" "67.2" "76.6" "48.9" "69.4" "651.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6183242122487478565" "False" "High" "IsMasterProtein" "Q8TDP1" "Ribonuclease H2 subunit C OS=Homo sapiens OX=9606 GN=RNASEH2C PE=1 SV=1" "0.000" "False" "9.898" "20" "3" "4" "3" "164" "17.8" "5.03" "12.34" "3" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus;other cell component" "" "Pf08615" "84153" "ENSG00000172922" "RNASEH2C" "hsa:84153; Q8TDP1; Q9H7F5" "" "" "0" "0" "1.071" "0.803" "1.193" "0.888" "0.896" "1.038" "0.730" "0.836" "2.684" "243.0" "260.3" "195.1" "289.8" "215.7" "217.8" "252.1" "177.4" "203.3" "652.2" "" "" "" "" "" "" "" "" "" "" "128.7" "144.3" "111.7" "133.5" "116.7" "121.2" "148.4" "96.8" "114.0" "652.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1174014872672808776" "False" "High" "IsMasterProtein" "Q96PP9" "Guanylate-binding protein 4 OS=Homo sapiens OX=9606 GN=GBP4 PE=1 SV=2" "0.000" "False" "9.890" "4" "3" "5" "3" "640" "73.1" "6.02" "10.86" "3" "stress response" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02263, Pf02841" "115361" "ENSG00000162654" "GBP4" "B2R630; hsa:115361; Q05D63; Q6NSL0; Q86T99; Q96PP9" "" "Interferon gamma signaling" "1" "0" "0.900" "0.961" "1.241" "1.205" "0.991" "1.091" "0.700" "0.932" "4.750" "70.0" "63.0" "67.3" "86.9" "84.4" "69.4" "76.4" "49.0" "65.3" "332.7" "" "" "" "" "" "" "" "" "" "" "37.1" "35.0" "38.6" "40.0" "45.6" "38.6" "45.0" "26.8" "36.6" "332.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5219962160653880547" "False" "High" "IsMasterProtein" "Q15785" "Mitochondrial import receptor subunit TOM34 OS=Homo sapiens OX=9606 GN=TOMM34 PE=1 SV=2" "0.000" "False" "9.885" "11" "4" "5" "4" "309" "34.5" "8.98" "13.26" "4" "other biological processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00515" "10953" "ENSG00000025772" "TOMM34" "hsa:10953; Q15785; Q53GH9; Q6IBN7; Q9NTZ3" "" "" "0" "0" "1.140" "0.951" "1.171" "1.203" "1.179" "1.047" "0.679" "1.024" "4.638" "160.5" "182.9" "152.6" "187.9" "193.1" "189.4" "168.1" "109.0" "164.4" "744.6" "" "" "" "" "" "" "" "" "" "" "85.0" "101.4" "87.4" "86.6" "104.5" "105.3" "98.9" "59.5" "92.2" "744.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1112180940687261840" "False" "High" "IsMasterProtein" "Q15185" "Prostaglandin E synthase 3 OS=Homo sapiens OX=9606 GN=PTGES3 PE=1 SV=1" "0.000" "False" "9.884" "11" "2" "6" "2" "160" "18.7" "4.54" "17.95" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04969" "10728" "ENSG00000110958" "PTGES3" "A8K7D0; B4DHP2; B4DP11; B4DP21; hsa:10728; Q15185; Q8WU70" "Aryl hydrocarbon receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Omega-6-fatty acids in senescence" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Potential therapeutics for SARS; Aryl hydrocarbon receptor signalling; Estrogen-dependent gene expression; Synthesis of Prostaglandins (PG) and Thromboxanes (TX); HSF1 activation; Attenuation phase" "12" "0" "1.036" "1.025" "0.938" "1.018" "1.021" "0.962" "0.764" "0.997" "4.071" "624.5" "646.8" "640.1" "586.0" "636.0" "637.8" "600.5" "477.3" "622.6" "2542.6" "" "" "" "" "" "" "" "" "" "" "330.7" "358.6" "366.6" "269.9" "344.1" "354.8" "353.4" "260.5" "349.2" "2542.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-275352047723705183" "False" "High" "IsMasterProtein" "Q8TF09" "Dynein light chain roadblock-type 2 OS=Homo sapiens OX=9606 GN=DYNLRB2 PE=1 SV=1" "0.000" "False" "9.872" "13" "1" "4" "1" "96" "10.8" "7.50" "10.15" "1" "other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf03259" "83657" "ENSG00000168589" "DYNLRB2" "hsa:83657; Q8TF09" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome" "Intraflagellar transport" "4" "0" "1.136" "1.077" "1.071" "1.078" "1.006" "0.996" "1.025" "1.000" "0.640" "187.8" "213.3" "202.3" "201.1" "202.5" "188.9" "187.0" "192.6" "187.9" "120.2" "" "" "" "" "" "" "" "" "" "" "99.5" "118.3" "115.9" "92.6" "109.6" "105.1" "110.1" "105.1" "105.4" "120.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7633283186484640293" "False" "High" "IsMasterProtein" "Q06547" "GA-binding protein subunit beta-1 OS=Homo sapiens OX=9606 GN=GABPB1 PE=1 SV=2" "0.000" "False" "9.869" "7" "3" "3" "3" "395" "42.5" "4.86" "9.22" "3" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf12796" "2553" "ENSG00000104064" "GABPB1" "A8IE52; hsa:2553; Q06545; Q06547; Q12940; Q12941; Q12942; Q8IYD0" "Myometrial relaxation and contraction pathways; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Mitochondrial gene expression" "" "3" "0" "0.990" "0.945" "1.168" "1.201" "1.115" "1.206" "0.919" "1.217" "4.280" "202.3" "200.3" "191.2" "236.3" "243.0" "225.6" "243.9" "185.9" "246.1" "865.8" "" "" "" "" "" "" "" "" "" "" "107.1" "111.1" "109.5" "108.8" "131.5" "125.5" "143.5" "101.5" "138.0" "865.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1329067276742603011" "False" "High" "IsMasterProtein" "Q8WYP5" "Protein ELYS OS=Homo sapiens OX=9606 GN=AHCTF1 PE=1 SV=3" "0.000" "False" "9.854" "2" "4" "4" "4" "2266" "252.3" "6.60" "9.73" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf13934, Pf16687" "25909" "ENSG00000153207" "AHCTF1" "A6NGM0; A8MSG9; A8MZ86; hsa:25909; Q7Z4E3; Q8IZA4; Q8WYP5; Q96EH9; Q9Y4Q6" "Gastric cancer network 2" "Separation of Sister Chromatids; EML4 and NUDC in mitotic spindle formation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "8" "0" "0.863" "0.909" "1.032" "1.023" "1.013" "1.235" "1.225" "1.319" "0.739" "439.7" "379.5" "399.7" "453.8" "450.0" "445.4" "543.1" "538.7" "579.8" "325.0" "" "" "" "" "" "" "" "" "" "" "232.8" "210.4" "228.9" "209.0" "243.5" "247.8" "319.7" "294.1" "325.2" "325.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8311044657227682609" "False" "High" "IsMasterProtein" "Q9BZE9" "Tether containing UBX domain for GLUT4 OS=Homo sapiens OX=9606 GN=ASPSCR1 PE=1 SV=1" "0.000" "False" "9.837" "4" "2" "3" "2" "553" "60.1" "6.64" "8.93" "2" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf00789, Pf11470" "79058" "ENSG00000169696" "ASPSCR1" "A8K3K9; hsa:79058; Q7Z6N7; Q8WV59; Q96LS5; Q96M40; Q9BZE9" "" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "1" "0" "0.867" "0.856" "1.155" "0.916" "0.858" "0.789" "0.857" "0.828" "1.451" "52.5" "45.5" "44.9" "60.6" "48.1" "45.0" "41.4" "45.0" "43.5" "76.2" "" "" "" "" "" "" "" "" "" "" "27.8" "25.2" "25.7" "27.9" "26.0" "25.0" "24.4" "24.5" "24.4" "76.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7530688595643988973" "False" "High" "IsMasterProtein" "Q13510" "Acid ceramidase OS=Homo sapiens OX=9606 GN=ASAH1 PE=1 SV=5" "0.000" "False" "9.818" "7" "3" "4" "3" "395" "44.6" "7.62" "10.61" "3" "other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02275, Pf15508" "427" "ENSG00000104763" "ASAH1" "E9PDS0; hsa:427; Q13510; Q6W898; Q96AS2" "Sphingolipid pathway; S1P receptor signal transduction; Sphingolipid metabolism: integrated pathway; Sphingolipid metabolism in senescence; Biosynthesis and turnover of 1-deoxy-sphingoid bases; Synthesis of ceramides and 1-deoxyceramides" "Neutrophil degranulation; Glycosphingolipid catabolism" "8" "0" "1.113" "1.147" "1.072" "1.077" "1.132" "1.175" "1.306" "1.117" "0.612" "163.0" "181.3" "186.9" "174.7" "175.5" "184.5" "191.5" "212.7" "182.1" "99.7" "" "" "" "" "" "" "" "" "" "" "86.3" "100.5" "107.0" "80.4" "94.9" "102.6" "112.7" "116.1" "102.1" "99.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6202573485252222351" "False" "High" "IsMasterProtein" "Q9NZD2" "Glycolipid transfer protein OS=Homo sapiens OX=9606 GN=GLTP PE=1 SV=3" "0.000" "False" "9.817" "9" "2" "2" "2" "209" "23.8" "7.39" "6.95" "2" "cell organization and biogenesis;other metabolic processes;stress response;transport" "cytosol" "transporter activity;other molecular function" "Pf08718" "51228" "ENSG00000139433" "GLTP" "hsa:51228; Q53Z13; Q96J68; Q9NZD2" "" "Glycosphingolipid transport" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8254999691274013684" "False" "High" "IsMasterProtein" "Q9HAV0" "Guanine nucleotide-binding protein subunit beta-4 OS=Homo sapiens OX=9606 GN=GNB4 PE=1 SV=3" "0.000" "False" "9.791" "8" "3" "4" "3" "340" "37.5" "6.00" "12.27" "3" "signal transduction" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00400" "59345" "ENSG00000114450" "GNB4" "B3KMH5; D3DNR8; hsa:59345; Q9HAV0" "Myometrial relaxation and contraction pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells" "G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Ca2+ pathway; G alpha (q) signalling events; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G alpha (12/13) signalling events; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation" "34" "0" "0.980" "0.914" "0.949" "1.030" "0.996" "0.954" "0.901" "0.884" "0.834" "364.3" "357.2" "332.9" "345.8" "375.1" "363.0" "347.6" "328.1" "322.2" "303.7" "" "" "" "" "" "" "" "" "" "" "192.9" "198.0" "190.6" "159.2" "202.9" "201.9" "204.6" "179.1" "180.7" "303.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5381217781487520932" "False" "High" "IsMasterProtein" "Q99536" "Synaptic vesicle membrane protein VAT-1 homolog OS=Homo sapiens OX=9606 GN=VAT1 PE=1 SV=2" "0.000" "False" "9.790" "4" "1" "4" "1" "393" "41.9" "6.29" "11.37" "1" "other biological processes" "non-structural extracellular;other membranes;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf08240, Pf13602" "10493" "ENSG00000108828" "VAT1" "A8K345; B0AZP7; B4DPX4; hsa:10493; Q13035; Q5BKZ7; Q96A39; Q99536; Q9BUT8" "" "Neutrophil degranulation" "1" "0" "0.971" "1.024" "1.089" "1.096" "1.054" "0.958" "0.967" "0.995" "0.706" "274.3" "266.3" "280.8" "298.6" "300.6" "289.0" "262.7" "265.3" "272.9" "193.7" "" "" "" "" "" "" "" "" "" "" "145.2" "147.6" "160.8" "137.5" "162.6" "160.7" "154.6" "144.8" "153.1" "193.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8349989266333908893" "False" "High" "IsMasterProtein" "P49841" "Glycogen synthase kinase-3 beta OS=Homo sapiens OX=9606 GN=GSK3B PE=1 SV=2" "0.000" "False" "9.787" "5" "1" "1" "1" "420" "46.7" "8.78" "5.22" "1" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "2932" "ENSG00000082701" "GSK3B" "D3DN89; hsa:2932; P49841; Q9BWH3; Q9UL47" "IL-5 signaling pathway; Androgen receptor signaling pathway; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; Cell cycle; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; Neural crest differentiation; IL-17 signaling pathway; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Focal adhesion; Copper homeostasis; Melatonin metabolism and effects; Wnt signaling pathway; IL6 signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Regulation of apoptosis by parathyroid hormone-related protein; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Wnt signaling pathway and pluripotency; PI3K/AKT/mTOR - vitamin D3 signaling; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; Acute viral myocarditis; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; NRF2-ARE regulation; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Gastrin signaling pathway; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Influence of laminopathies on Wnt signaling; MAP3K1 role in promoting and blocking gonadal determination; Overlap between signal transduction pathways contributing to LMNA laminopathies; Glycogen synthesis and degradation; Pleural mesothelioma; CCL18 signaling pathway; Alzheimer's disease; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Neurogenesis regulation in the olfactory epithelium; Sildenafil treatment; Macrophage-stimulating protein (MSP) signaling network map; HDAC6 interactions in the central nervous system; Notch signaling pathway; ErbB signaling pathway; DNA damage response (only ATM dependent)" "Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Ubiquitin-dependent degradation of Cyclin D; Regulation of RUNX2 expression and activity; Regulation of HSF1-mediated heat shock response; Constitutive Signaling by AKT1 E17K in Cancer; B-WICH complex positively regulates rRNA expression; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; CRMPs in Sema3A signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; AKT phosphorylates targets in the cytosol; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Maturation of nucleoprotein; Maturation of nucleoprotein" "95" "0" "1.243" "1.131" "1.271" "1.150" "0.995" "1.174" "0.985" "0.891" "0.785" "35.3" "43.9" "40.0" "44.9" "40.6" "35.1" "41.4" "34.8" "31.5" "27.7" "" "" "" "" "" "" "" "" "" "" "18.7" "24.3" "22.9" "20.7" "22.0" "19.5" "24.4" "19.0" "17.7" "27.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3876256361286906855" "False" "High" "IsMasterProtein" "P62269" "Small ribosomal subunit protein uS13 OS=Homo sapiens OX=9606 GN=RPS18 PE=1 SV=3" "0.000" "False" "9.783" "22" "4" "4" "4" "152" "17.7" "10.99" "12.20" "4" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00416" "6222" "ENSG00000096150; ENSG00000223367; ENSG00000226225; ENSG00000231500; ENSG00000235650" "RPS18" "hsa:6222; P25232; P62269; Q5SUJ3; Q6IPF8" "Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.994" "1.068" "1.199" "1.191" "1.177" "1.197" "1.032" "1.277" "1.434" "238.2" "236.8" "254.3" "285.6" "283.6" "280.4" "285.0" "245.9" "304.2" "341.5" "" "" "" "" "" "" "" "" "" "" "126.1" "131.3" "145.7" "131.5" "153.4" "156.0" "167.7" "134.2" "170.6" "341.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5329658274444496515" "False" "High" "IsMasterProtein" "O95394" "Phosphoacetylglucosamine mutase OS=Homo sapiens OX=9606 GN=PGM3 PE=1 SV=1" "0.000" "False" "9.781" "6" "4" "4" "4" "542" "59.8" "6.25" "8.44" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00408, Pf02878, Pf21404, Pf21405" "5238" "ENSG00000013375" "PGM3" "B2RB65; B4DX94; D6RF12; E1P547; E9PF86; hsa:5238; O95394; Q5JWR4; Q96J46; Q9H8G5; Q9NS94; Q9NTT6; Q9UFV5; Q9UIY2" "UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "Synthesis of UDP-N-acetyl-glucosamine" "3" "0" "1.071" "0.944" "1.043" "1.024" "0.991" "0.937" "0.981" "0.929" "0.858" "262.9" "281.6" "248.3" "274.4" "269.2" "260.6" "246.3" "258.0" "244.2" "225.5" "" "" "" "" "" "" "" "" "" "" "139.2" "156.1" "142.2" "126.3" "145.7" "145.0" "144.9" "140.8" "137.0" "225.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-705908850981217680" "False" "High" "IsMasterProtein" "Q9NWZ5" "Uridine-cytidine kinase-like 1 OS=Homo sapiens OX=9606 GN=UCKL1 PE=1 SV=2" "0.000" "False" "9.773" "6" "4" "6" "4" "548" "61.1" "7.36" "12.95" "4" "other metabolic processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00485, Pf14681" "54963" "ENSG00000198276" "UCKL1" "B7Z8N2; hsa:54963; Q5JWV0; Q70AQ5; Q8N524; Q9H3Z2; Q9NWZ5" "Pyrimidine metabolism" "Pyrimidine salvage" "2" "0" "1.007" "0.954" "0.973" "1.049" "0.932" "0.971" "0.935" "0.905" "1.091" "233.6" "235.2" "222.8" "227.3" "245.1" "217.7" "226.8" "218.5" "211.5" "254.9" "" "" "" "" "" "" "" "" "" "" "123.7" "130.4" "127.6" "104.7" "132.6" "121.1" "133.5" "119.3" "118.6" "254.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4468909642596951639" "False" "High" "IsMasterProtein" "Q15020" "Squamous cell carcinoma antigen recognized by T-cells 3 OS=Homo sapiens OX=9606 GN=SART3 PE=1 SV=1" "0.000" "False" "9.761" "3" "3" "4" "3" "963" "109.9" "5.57" "10.27" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf05391, Pf16605" "9733" "ENSG00000075856" "SART3" "A8K2E4; B7ZKM0; hsa:9733; Q15020; Q2M2H0; Q58F06; Q8IUS1; Q96J95" "" "" "0" "0" "1.076" "1.087" "1.204" "1.336" "1.038" "1.109" "0.791" "1.016" "4.547" "186.6" "200.8" "202.8" "224.7" "249.3" "193.8" "206.9" "147.6" "189.7" "848.5" "" "" "" "" "" "" "" "" "" "" "98.8" "111.3" "116.2" "103.5" "134.9" "107.8" "121.8" "80.6" "106.4" "848.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2725190465399901470" "False" "High" "IsMasterProtein" "P62829" "Large ribosomal subunit protein uL14 OS=Homo sapiens OX=9606 GN=RPL23 PE=1 SV=1" "0.000" "False" "9.743" "25" "4" "5" "4" "140" "14.9" "10.51" "12.40" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00238" "9349" "ENSG00000125691" "RPL23" "hsa:9349; P23131; P24048; P62829; Q29246; Q3SWV7; Q6P5S1" "Cytoplasmic ribosomal proteins; 17q12 copy number variation syndrome" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "1.049" "1.161" "1.204" "1.184" "1.173" "1.182" "1.302" "1.277" "1.531" "269.5" "282.8" "312.9" "324.6" "319.0" "316.1" "318.5" "350.8" "344.2" "412.7" "" "" "" "" "" "" "" "" "" "" "142.7" "156.8" "179.2" "149.5" "172.6" "175.8" "187.5" "191.5" "193.1" "412.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6209477172492729631" "False" "High" "IsMasterProtein" "Q9UPN6" "SR-related and CTD-associated factor 8 OS=Homo sapiens OX=9606 GN=SCAF8 PE=1 SV=1" "0.000" "False" "9.713" "3" "4" "5" "4" "1271" "140.4" "8.29" "12.67" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf04818" "22828" "ENSG00000213079" "SCAF8" "B7Z888; hsa:22828; Q5TBU6; Q6NSK3; Q9BQN8; Q9BX43; Q9UPN6" "" "" "0" "0" "1.570" "0.982" "1.280" "1.068" "0.998" "1.105" "1.099" "1.055" "1.591" "339.8" "533.4" "333.7" "434.8" "363.0" "339.0" "375.6" "373.2" "358.6" "540.4" "" "" "" "" "" "" "" "" "" "" "179.9" "295.7" "191.1" "200.3" "196.4" "188.6" "221.0" "203.7" "201.2" "540.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2311027039317612116" "False" "High" "IsMasterProtein" "Q9Y3B8" "Oligoribonuclease, mitochondrial OS=Homo sapiens OX=9606 GN=REXO2 PE=1 SV=3" "0.000" "False" "9.713" "8" "2" "2" "2" "237" "26.8" "6.87" "7.55" "2" "DNA metabolism;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00929" "25996" "ENSG00000076043" "REXO2" "B2R532; hsa:25996; Q32Q18; Q53FT1; Q6FIC6; Q9UFY7; Q9Y3B8" "" "Mitochondrial RNA degradation" "1" "0" "1.011" "1.093" "0.901" "0.989" "0.970" "1.039" "1.099" "1.010" "0.503" "498.5" "504.1" "544.7" "449.0" "493.2" "483.5" "517.8" "547.8" "503.5" "250.9" "" "" "" "" "" "" "" "" "" "" "263.9" "279.5" "311.9" "206.8" "266.8" "269.0" "304.8" "299.0" "282.5" "250.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9145991611537025162" "False" "High" "IsMasterProtein" "Q16527" "Cysteine and glycine-rich protein 2 OS=Homo sapiens OX=9606 GN=CSRP2 PE=1 SV=3" "0.000" "False" "9.704" "13" "2" "3" "2" "193" "20.9" "8.62" "6.14" "2" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00412" "1466" "ENSG00000175183" "CSRP2" "hsa:1466; Q16527; Q93030" "Mesodermal commitment pathway; VEGFA-VEGFR2 signaling; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity" "" "3" "0" "0.951" "0.948" "1.052" "0.965" "0.996" "0.925" "0.960" "0.977" "0.819" "543.6" "516.8" "515.1" "572.0" "524.6" "541.4" "503.1" "521.9" "531.0" "445.1" "" "" "" "" "" "" "" "" "" "" "287.9" "286.6" "295.0" "263.4" "283.8" "301.2" "296.1" "284.9" "297.9" "445.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4201760533929060036" "False" "High" "IsMasterProtein" "P63313" "Thymosin beta-10 OS=Homo sapiens OX=9606 GN=TMSB10 PE=1 SV=2" "0.000" "False" "9.686" "34" "3" "7" "3" "44" "5.0" "5.36" "22.28" "3" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf01290" "9168" "ENSG00000034510" "TMSB10" "hsa:9168; P13472; P63313; Q596K9" "VEGFA-VEGFR2 signaling; Extrafollicular and follicular B cell activation by SARS-CoV-2" "" "2" "0" "0.957" "1.317" "1.160" "0.650" "0.674" "0.691" "0.975" "0.713" "0.377" "1874.2" "1793.1" "2468.5" "2173.5" "1217.7" "1263.2" "1295.0" "1826.5" "1337.0" "707.5" "" "" "" "" "" "" "" "" "" "" "992.4" "994.1" "1413.7" "1001.0" "658.8" "702.7" "762.2" "997.0" "750.0" "707.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3786369172385558853" "False" "High" "IsMasterProtein" "P19388" "DNA-directed RNA polymerases I, II, and III subunit RPABC1 OS=Homo sapiens OX=9606 GN=POLR2E PE=1 SV=4" "0.000" "False" "9.683" "9" "2" "4" "2" "210" "24.5" "5.95" "11.15" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01191, Pf03871" "5434" "ENSG00000099817" "POLR2E" "B2R6L4; D6W5Y1; hsa:5434; O43380; P19388; Q6PIH5; Q9BT06" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM" "57" "0" "1.002" "1.042" "1.075" "0.984" "1.044" "1.198" "0.964" "1.086" "3.196" "233.2" "233.7" "243.0" "250.7" "229.5" "243.4" "279.5" "224.8" "253.3" "745.2" "" "" "" "" "" "" "" "" "" "" "123.5" "129.5" "139.2" "115.4" "124.2" "135.4" "164.5" "122.7" "142.1" "745.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7573385717766537595" "False" "High" "IsMasterProtein" "Q9GZT9" "Egl nine homolog 1 OS=Homo sapiens OX=9606 GN=EGLN1 PE=1 SV=1" "0.000" "False" "9.671" "5" "3" "3" "3" "426" "46.0" "8.53" "5.93" "3" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01753, Pf13640" "54583" "ENSG00000135766" "EGLN1" "hsa:54583; Q8N3M8; Q9BZS8; Q9BZT0; Q9GZT9" "Photodynamic therapy-induced HIF-1 survival signaling; Hereditary leiomyomatosis and renal cell carcinoma pathway; Type 2 papillary renal cell carcinoma; Markers of kidney cell lineage" "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha" "5" "0" "1.100" "1.240" "1.743" "1.198" "1.264" "1.251" "1.078" "1.416" "1.425" "17.7" "19.4" "21.9" "30.8" "21.2" "22.3" "22.1" "19.0" "25.0" "25.2" "" "" "" "" "" "" "" "" "" "" "9.4" "10.8" "12.5" "14.2" "11.4" "12.4" "13.0" "10.4" "14.0" "25.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5531116507177860716" "False" "High" "IsMasterProtein" "Q06609" "DNA repair protein RAD51 homolog 1 OS=Homo sapiens OX=9606 GN=RAD51 PE=1 SV=1" "0.000" "False" "9.657" "9" "2" "2" "2" "339" "36.9" "5.60" "7.26" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423, Pf14520" "5888" "ENSG00000051180" "RAD51" "B0FXP0; B2R8T6; hsa:5888; Q06609; Q6FHX9; Q6ZNA8; Q9BV60" "miRNA regulation of DNA damage response; Homologous recombination; ATM signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Ovarian infertility; Breast cancer pathway; Pancreatic adenocarcinoma pathway; DNA repair pathways, full network; Primary ovarian insufficiency; DNA damage response" "Resolution of D-loop Structures through Holliday Junction Intermediates; Transcriptional Regulation by E2F6; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "23" "0" "0.934" "0.912" "1.017" "1.116" "0.992" "0.883" "0.838" "0.896" "0.817" "230.9" "215.6" "210.5" "234.8" "257.7" "229.2" "203.8" "193.4" "206.8" "188.5" "" "" "" "" "" "" "" "" "" "" "122.3" "119.5" "120.5" "108.1" "139.4" "127.5" "119.9" "105.6" "116.0" "188.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1866908035804814240" "False" "High" "IsMasterProtein" "P22059" "Oxysterol-binding protein 1 OS=Homo sapiens OX=9606 GN=OSBP PE=1 SV=1" "0.000" "False" "9.633" "4" "4" "6" "4" "807" "89.4" "7.30" "13.45" "4" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00169, Pf01237" "5007" "ENSG00000110048" "OSBP" "hsa:5007; P22059; Q6P524" "" "Sphingolipid de novo biosynthesis; Synthesis of bile acids and bile salts" "2" "0" "1.062" "1.015" "0.891" "0.926" "0.953" "0.892" "0.759" "1.001" "1.304" "382.9" "406.6" "388.5" "341.3" "354.4" "365.1" "341.4" "290.8" "383.4" "499.1" "" "" "" "" "" "" "" "" "" "" "202.8" "225.5" "222.5" "157.2" "191.8" "203.1" "200.9" "158.7" "215.1" "499.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7317656068237787361" "False" "High" "IsMasterProtein" "Q15836" "Vesicle-associated membrane protein 3 OS=Homo sapiens OX=9606 GN=VAMP3 PE=1 SV=3" "0.000" "False" "9.625" "24" "2" "2" "2" "100" "11.3" "8.79" "6.86" "2" "cell adhesion;cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00957" "9341" "ENSG00000049245" "VAMP3" "hsa:9341; Q15836; Q9BRV4" "" "CDC42 GTPase cycle; RAC1 GTPase cycle; ER-Phagosome pathway; RHOC GTPase cycle; RHOA GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network; RHOH GTPase cycle" "17" "0" "1.056" "0.982" "1.185" "1.189" "1.235" "1.088" "1.092" "0.877" "0.875" "73.9" "78.0" "72.5" "87.5" "87.8" "91.2" "80.4" "80.7" "64.7" "64.6" "" "" "" "" "" "" "" "" "" "" "39.1" "43.2" "41.5" "40.3" "47.5" "50.7" "47.3" "44.0" "36.3" "64.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3428809261446700766" "False" "High" "IsMasterProtein" "Q9UNN5" "FAS-associated factor 1 OS=Homo sapiens OX=9606 GN=FAF1 PE=1 SV=2" "0.000" "False" "9.616" "6" "5" "6" "5" "650" "73.9" "4.88" "15.85" "5" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00789, Pf14555, Pf21021" "11124" "ENSG00000185104" "FAF1" "hsa:11124; Q549F0; Q9UF34; Q9UNN5; Q9UNT3; Q9Y2Z3" "Retinoblastoma gene in cancer; Fas ligand pathway and stress induction of heat shock proteins; VEGFA-VEGFR2 signaling" "" "3" "0" "1.118" "1.096" "1.152" "1.199" "1.091" "1.183" "1.091" "1.202" "0.845" "321.3" "359.4" "352.3" "370.0" "385.2" "350.6" "380.0" "350.5" "386.1" "271.4" "" "" "" "" "" "" "" "" "" "" "170.1" "199.2" "201.8" "170.4" "208.4" "195.0" "223.6" "191.3" "216.6" "271.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4146618986531713622" "False" "High" "IsMasterProtein" "P46782" "Small ribosomal subunit protein uS7 OS=Homo sapiens OX=9606 GN=RPS5 PE=1 SV=4" "0.000" "False" "9.615" "13" "3" "4" "3" "204" "22.9" "9.72" "6.61" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00177" "6193" "ENSG00000083845" "RPS5" "B2R4T2; hsa:6193; P46782; Q96BN0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2803114814399122734" "False" "High" "IsMasterProtein" "Q8NFI3" "Cytosolic endo-beta-N-acetylglucosaminidase OS=Homo sapiens OX=9606 GN=ENGASE PE=1 SV=1" "0.000" "False" "9.608" "4" "3" "4" "3" "743" "83.9" "6.79" "7.75" "3" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf03644" "64772" "ENSG00000167280" "ENGASE" "hsa:64772; Q659F0; Q8NFI3; Q8TB86; Q9H6U4" "" "N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "1" "0" "0.947" "0.913" "0.900" "1.058" "1.053" "0.989" "0.940" "0.991" "0.660" "322.4" "305.2" "294.5" "290.1" "341.0" "339.4" "318.9" "303.0" "319.5" "212.7" "" "" "" "" "" "" "" "" "" "" "170.7" "169.2" "168.7" "133.6" "184.5" "188.8" "187.7" "165.4" "179.2" "212.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4323933511445947970" "False" "High" "IsMasterProtein" "P43405" "Tyrosine-protein kinase SYK OS=Homo sapiens OX=9606 GN=SYK PE=1 SV=1" "0.000" "False" "9.608" "6" "4" "4" "3" "635" "72.0" "8.25" "5.73" "4" "cell adhesion;cell-cell signaling;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00017, Pf07714" "6850" "ENSG00000165025" "SYK" "hsa:6850; P43405" "IL-5 signaling pathway; RANKL/RANK signaling pathway; B cell receptor signaling pathway; IL-3 signaling pathway; Microglia pathogen phagocytosis pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; IL-2 signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2" "Integrin signaling; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; CLEC7A (Dectin-1) signaling; Regulation of signaling by CBL; GPVI-mediated activation cascade; DAP12 signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Interleukin-2 signaling; Dectin-2 family; FLT3 signaling through SRC family kinases" "30" "0" "0.904" "0.974" "1.212" "0.929" "0.925" "0.808" "0.803" "0.809" "4.267" "100.3" "90.7" "97.7" "121.6" "93.3" "92.9" "81.0" "80.6" "81.1" "428.1" "" "" "" "" "" "" "" "" "" "" "53.1" "50.3" "56.0" "56.0" "50.5" "51.7" "47.7" "44.0" "45.5" "428.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8004592446864816783" "False" "High" "IsMasterProtein" "O75688" "Protein phosphatase 1B OS=Homo sapiens OX=9606 GN=PPM1B PE=1 SV=1" "0.000" "False" "9.607" "6" "3" "3" "3" "479" "52.6" "5.05" "9.33" "3" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf00481, Pf07830" "5495" "ENSG00000138032" "PPM1B" "hsa:5495; O75688; Q461Q2; Q4J6C1; Q4J6C2; Q658R4; Q96ER6; Q9HAY8" "MAPK signaling pathway" "ISG15 antiviral mechanism; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants" "4" "0" "1.003" "1.002" "0.934" "0.939" "1.083" "1.014" "1.080" "1.043" "0.979" "548.7" "550.5" "549.7" "512.4" "515.2" "594.5" "556.4" "592.6" "572.4" "537.2" "" "" "" "" "" "" "" "" "" "" "290.5" "305.2" "314.8" "236.0" "278.8" "330.7" "327.5" "323.5" "321.1" "537.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9153257875265109999" "False" "High" "IsMasterProtein" "Q9NYJ1" "Cytochrome c oxidase assembly factor 4 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=COA4 PE=1 SV=2" "0.000" "False" "9.583" "36" "3" "3" "3" "87" "10.1" "6.04" "6.94" "3" "cell organization and biogenesis" "mitochondrion" "" "Pf06747" "51287" "ENSG00000181924" "COA4" "B2RAA0; hsa:51287; Q69YU4; Q9NYJ1" "" "Mitochondrial protein import" "1" "0" "1.218" "1.053" "1.124" "1.186" "0.911" "1.134" "1.084" "1.002" "0.471" "109.8" "133.7" "115.6" "123.4" "130.2" "100.0" "124.4" "119.0" "109.9" "51.7" "" "" "" "" "" "" "" "" "" "" "58.1" "74.1" "66.2" "56.8" "70.4" "55.6" "73.2" "64.9" "61.7" "51.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7476977248749324952" "False" "High" "IsMasterProtein" "Q7Z4H8" "Protein O-glucosyltransferase 3 OS=Homo sapiens OX=9606 GN=POGLUT3 PE=1 SV=2" "0.000" "False" "9.580" "6" "4" "4" "4" "507" "58.5" "8.24" "7.68" "4" "protein metabolism;other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf00630, Pf05686" "143888" "ENSG00000178202" "POGLUT3" "hsa:143888; Q6UWW2; Q6ZUM9; Q7Z4H8; Q8N7L8; Q8NE24" "" "" "0" "0" "0.896" "0.898" "0.963" "0.966" "0.957" "0.831" "0.985" "1.054" "0.913" "625.5" "560.6" "561.6" "602.3" "604.4" "598.8" "519.9" "615.9" "659.3" "571.3" "" "" "" "" "" "" "" "" "" "" "331.2" "310.8" "321.6" "277.4" "327.0" "333.1" "306.0" "336.2" "369.8" "571.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1400843138587659979" "False" "High" "IsMasterProtein" "P98175" "RNA-binding protein 10 OS=Homo sapiens OX=9606 GN=RBM10 PE=1 SV=3" "0.000" "False" "9.575" "3" "3" "4" "3" "930" "103.5" "5.97" "10.37" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00641, Pf01585, Pf17780" "8241" "ENSG00000182872" "RBM10" "A0A0A0MR66; C4AM81; hsa:8241; P98175; Q14136; Q5JRR2; Q9BTE4; Q9BTX0; Q9NTB1" "" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "2" "0" "1.040" "0.959" "1.097" "1.066" "0.957" "1.307" "1.132" "1.358" "1.500" "123.0" "128.0" "118.0" "134.9" "131.2" "117.7" "160.8" "139.2" "167.1" "184.6" "" "" "" "" "" "" "" "" "" "" "65.1" "70.9" "67.6" "62.1" "71.0" "65.5" "94.7" "76.0" "93.7" "184.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8527092773428768711" "False" "High" "IsMasterProtein" "Q13561" "Dynactin subunit 2 OS=Homo sapiens OX=9606 GN=DCTN2 PE=1 SV=4" "0.000" "False" "9.574" "7" "2" "2" "2" "401" "44.2" "5.21" "6.11" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf04912" "10540" "ENSG00000175203" "DCTN2" "B2RBK5; hsa:10540; Q13561; Q86YN2; Q9BW17" "Vasopressin-regulated water reabsorption" "Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane" "12" "0" "1.163" "1.080" "0.890" "1.028" "1.123" "1.133" "1.039" "0.945" "1.540" "46.8" "54.4" "50.5" "41.6" "48.1" "52.5" "53.0" "48.6" "44.2" "72.0" "" "" "" "" "" "" "" "" "" "" "24.8" "30.1" "28.9" "19.2" "26.0" "29.2" "31.2" "26.5" "24.8" "72.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6827410314429019344" "False" "High" "IsMasterProtein" "Q9UM22" "Mammalian ependymin-related protein 1 OS=Homo sapiens OX=9606 GN=EPDR1 PE=1 SV=2" "0.000" "False" "9.572" "9" "2" "4" "2" "224" "25.4" "6.60" "7.97" "2" "cell adhesion;other biological processes" "non-structural extracellular;other cytoplasmic organelle" "other molecular function" "Pf00811" "54749" "ENSG00000086289" "EPDR1" "A8K4C0; C9JYS3; hsa:54749; Q06BL0; Q99M77; Q9UM22" "" "" "0" "0" "0.949" "1.036" "0.815" "0.964" "0.938" "0.904" "1.000" "0.995" "0.448" "593.6" "563.1" "615.3" "483.9" "572.5" "556.7" "536.5" "593.8" "590.8" "266.0" "" "" "" "" "" "" "" "" "" "" "314.3" "312.2" "352.4" "222.9" "309.7" "309.6" "315.8" "324.1" "331.4" "266.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5667017434232915728" "False" "High" "IsMasterProtein" "Q9Y618" "Nuclear receptor corepressor 2 OS=Homo sapiens OX=9606 GN=NCOR2 PE=1 SV=3" "0.000" "False" "9.571" "1" "4" "4" "3" "2514" "273.5" "7.59" "9.49" "4" "transport;developmental processes;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00249, Pf15784" "9612" "ENSG00000196498" "NCOR2" "hsa:9612; O00613; O15416; O15421; Q13354; Q56D06; Q59GM0; Q9Y5U0; Q9Y618" "Androgen receptor signaling pathway; Adipogenesis; Aryl hydrocarbon receptor pathway; Notch signaling; Rett syndrome; Notch signaling pathway" "Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; SUMOylation of transcription cofactors; HCMV Early Events; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HDACs deacetylate histones; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis" "23" "0" "0.938" "0.957" "1.176" "1.038" "1.079" "1.039" "1.175" "1.125" "1.200" "241.4" "226.5" "231.0" "283.8" "250.7" "260.6" "250.8" "283.7" "271.6" "289.7" "" "" "" "" "" "" "" "" "" "" "127.8" "125.6" "132.3" "130.7" "135.6" "144.9" "147.6" "154.9" "152.4" "289.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3328900627537449382" "False" "High" "IsMasterProtein" "Q03111" "Protein ENL OS=Homo sapiens OX=9606 GN=MLLT1 PE=1 SV=2" "0.000" "False" "9.537" "4" "2" "2" "2" "559" "62.0" "8.59" "5.87" "2" "other biological processes" "cytosol;nucleus" "other molecular function" "Pf03366, Pf17793" "4298" "ENSG00000130382" "MLLT1" "hsa:4298; Q03111; Q14768" "" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3279905099390366435" "False" "High" "IsMasterProtein" "Q6FIF0" "AN1-type zinc finger protein 6 OS=Homo sapiens OX=9606 GN=ZFAND6 PE=1 SV=2" "0.000" "False" "9.527" "10" "2" "2" "2" "208" "22.5" "7.20" "7.51" "2" "cell organization and biogenesis;other biological processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf01428, Pf01754" "54469" "ENSG00000086666" "ZFAND6" "D3DW92; D3DW94; hsa:54469; O95792; Q6FIF0; Q9BQF7; Q9GZY3" "" "Peroxisomal protein import" "1" "0" "0.929" "1.005" "0.995" "1.042" "1.105" "0.864" "1.028" "1.159" "0.739" "167.4" "155.5" "168.2" "166.5" "174.4" "184.9" "144.6" "172.0" "194.0" "123.7" "" "" "" "" "" "" "" "" "" "" "88.6" "86.2" "96.3" "76.7" "94.3" "102.8" "85.1" "93.9" "108.8" "123.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2002757993896463050" "False" "High" "IsMasterProtein" "Q9NQW6" "Anillin OS=Homo sapiens OX=9606 GN=ANLN PE=1 SV=2" "0.000" "False" "9.524" "3" "4" "6" "4" "1124" "124.1" "8.07" "12.98" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00169, Pf08174, Pf16018" "54443" "ENSG00000011426" "ANLN" "hsa:54443; Q5CZ78; Q6NSK5; Q9H8Y4; Q9NQW6; Q9NVN9; Q9NVP0" "Retinoblastoma gene in cancer; Nephrotic syndrome" "RHOA GTPase cycle; RHOC GTPase cycle; RHOB GTPase cycle" "5" "0" "1.045" "0.952" "1.057" "1.086" "0.968" "1.381" "1.205" "1.380" "1.389" "181.8" "189.9" "173.0" "192.2" "197.4" "175.9" "251.1" "219.1" "251.0" "252.5" "" "" "" "" "" "" "" "" "" "" "96.3" "105.3" "99.1" "88.5" "106.8" "97.9" "147.8" "119.6" "140.8" "252.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1603503262744250251" "False" "High" "IsMasterProtein" "P62805" "Histone H4 OS=Homo sapiens OX=9606 GN=H4C16 PE=1 SV=2" "0.000" "False" "9.523" "27" "3" "3" "3" "103" "11.4" "11.36" "8.10" "3" "cell organization and biogenesis;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15511" "121504; 554313; 8294; 8359; 8360; 8361; 8362; 8363; 8364; 8365; 8366; 8367; 8368; 8370" "ENSG00000158406; ENSG00000197061; ENSG00000197238; ENSG00000197837; ENSG00000270276; ENSG00000270882; ENSG00000273542; ENSG00000274618; ENSG00000275126; ENSG00000276180; ENSG00000276966; ENSG00000277157; ENSG00000278637; ENSG00000278705" "H4C1; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9" "A2VCL0; hsa:121504; hsa:554313; hsa:8294; hsa:8359; hsa:8360; hsa:8361; hsa:8362; hsa:8363; hsa:8364; hsa:8365; hsa:8366; hsa:8367; hsa:8368; hsa:8370; P02304; P02305; P62805; Q6DRA9; Q6FGB8; Q6NWP7" "Gastric cancer network 1; Histone modifications; 22q11.2 copy number variation syndrome; Male infertility; Type II interferon signaling" "Meiotic synapsis; Estrogen-dependent gene expression; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Meiotic recombination; SUMOylation of chromatin organization proteins; Amyloid fiber formation; HCMV Late Events; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HCMV Early Events; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RMTs methylate histone arginines; HDMs demethylate histones; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; Nonhomologous End-Joining (NHEJ); RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Replacement of protamines by nucleosomes in the male pronucleus" "52" "0" "1.123" "1.235" "1.748" "1.116" "1.217" "1.280" "1.094" "1.122" "0.982" "79.1" "88.8" "97.6" "138.2" "88.2" "96.2" "101.2" "86.5" "88.7" "77.7" "" "" "" "" "" "" "" "" "" "" "41.9" "49.2" "55.9" "63.7" "47.7" "53.5" "59.5" "47.2" "49.8" "77.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3538094465215650253" "False" "High" "IsMasterProtein" "Q8N4J0" "Carnosine N-methyltransferase OS=Homo sapiens OX=9606 GN=CARNMT1 PE=1 SV=1" "0.000" "False" "9.510" "7" "3" "6" "3" "409" "47.2" "6.32" "14.13" "3" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf07942" "138199" "ENSG00000156017" "CARNMT1" "hsa:138199; Q7Z383; Q8N4J0; Q8N7C5" "" "Histidine catabolism" "1" "0" "1.029" "0.867" "0.904" "1.000" "0.954" "0.964" "0.893" "0.853" "0.640" "288.1" "296.3" "249.7" "260.4" "288.1" "275.0" "277.6" "257.2" "245.8" "184.4" "" "" "" "" "" "" "" "" "" "" "152.5" "164.3" "143.0" "119.9" "155.9" "152.9" "163.4" "140.4" "137.9" "184.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2558659697255910600" "False" "High" "IsMasterProtein" "Q92747" "Actin-related protein 2/3 complex subunit 1A OS=Homo sapiens OX=9606 GN=ARPC1A PE=1 SV=2" "0.000" "False" "9.486" "7" "3" "5" "3" "370" "41.5" "8.18" "7.80" "3" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00400" "10552" "ENSG00000241685" "ARPC1A" "A4D276; B4DLQ7; D6W5S1; hsa:10552; Q7Z5U8; Q86WU5; Q8IXQ0; Q92747" "Pathogenic Escherichia coli infection" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Clathrin-mediated endocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling" "6" "0" "1.036" "0.970" "1.123" "0.909" "0.980" "0.980" "0.896" "0.865" "0.798" "637.8" "660.5" "618.5" "716.2" "580.0" "624.8" "625.1" "571.2" "551.9" "509.2" "" "" "" "" "" "" "" "" "" "" "337.7" "366.2" "354.2" "329.8" "313.8" "347.6" "367.9" "311.8" "309.6" "509.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3864201792584752389" "False" "High" "IsMasterProtein" "Q03188" "Centromere protein C OS=Homo sapiens OX=9606 GN=CENPC PE=1 SV=2" "0.000" "False" "9.476" "3" "3" "3" "3" "943" "106.8" "9.39" "8.03" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11699, Pf15620, Pf15622" "1060" "ENSG00000145241" "CENPC" "hsa:1060; Q03188; Q6PIR0; Q8IW27; Q9P0M5" "" "Separation of Sister Chromatids; Deposition of new CENPA-containing nucleosomes at the centromere; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "1.016" "0.902" "1.034" "1.000" "0.955" "1.413" "1.623" "1.508" "0.897" "103.1" "104.8" "93.0" "106.7" "103.1" "98.5" "145.8" "167.5" "155.6" "92.6" "" "" "" "" "" "" "" "" "" "" "54.6" "58.1" "53.3" "49.1" "55.8" "54.8" "85.8" "91.4" "87.3" "92.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3331703410720076251" "False" "High" "IsMasterProtein" "Q96BN8" "Ubiquitin thioesterase otulin OS=Homo sapiens OX=9606 GN=OTULIN PE=1 SV=3" "0.000" "False" "9.476" "10" "4" "4" "4" "352" "40.2" "5.47" "10.34" "4" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf16218" "90268" "ENSG00000154124" "OTULIN" "D3DTD3; hsa:90268; Q8NAS0; Q96BN8; Q96IA3" "" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Regulation of TNFR1 signaling" "2" "0" "1.064" "1.061" "1.228" "1.028" "0.939" "1.124" "0.758" "1.154" "5.244" "164.6" "175.1" "174.5" "202.0" "169.1" "154.6" "185.0" "124.7" "189.9" "862.9" "" "" "" "" "" "" "" "" "" "" "87.1" "97.1" "99.9" "93.0" "91.5" "86.0" "108.9" "68.1" "106.5" "862.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7973916192928746401" "False" "High" "IsMasterProtein" "Q8N6N7" "Acyl-CoA-binding domain-containing protein 7 OS=Homo sapiens OX=9606 GN=ACBD7 PE=1 SV=1" "0.000" "False" "9.470" "26" "2" "2" "2" "88" "9.8" "6.71" "6.26" "2" "other metabolic processes" "" "other molecular function" "Pf00887" "414149" "ENSG00000176244" "ACBD7" "A6NCI2; B3KTG8; hsa:414149; Q8N6N7" "" "Mitochondrial Fatty Acid Beta-Oxidation" "1" "0" "0.962" "1.071" "1.090" "1.065" "0.993" "1.013" "1.069" "0.966" "0.643" "332.5" "319.8" "356.0" "362.4" "354.2" "330.1" "336.9" "355.5" "321.1" "213.8" "" "" "" "" "" "" "" "" "" "" "176.1" "177.3" "203.9" "166.9" "191.7" "183.6" "198.3" "194.1" "180.1" "213.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3667364436417788912" "False" "High" "IsMasterProtein" "Q9BYV8" "Centrosomal protein of 41 kDa OS=Homo sapiens OX=9606 GN=CEP41 PE=1 SV=1" "0.000" "False" "9.461" "9" "2" "2" "2" "373" "41.3" "8.32" "6.51" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "cytosol;cytoskeleton;other cell component" "" "Pf00581" "95681" "ENSG00000106477" "CEP41" "A4D1M0; B4DQ35; F5H0V6; hsa:95681; Q7Z496; Q86TM1; Q8NFU8; Q9BYV8; Q9H6A3; Q9NPV3" "Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "10" "0" "1.064" "0.842" "1.030" "0.787" "0.879" "0.924" "0.779" "0.962" "2.358" "113.1" "120.3" "95.2" "116.6" "89.0" "99.5" "104.5" "88.1" "108.8" "266.8" "" "" "" "" "" "" "" "" "" "" "59.9" "66.7" "54.5" "53.7" "48.2" "55.3" "61.5" "48.1" "61.0" "266.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4842637441270179392" "False" "High" "IsMasterProtein" "Q9BU76" "Multiple myeloma tumor-associated protein 2 OS=Homo sapiens OX=9606 GN=MMTAG2 PE=1 SV=1" "0.000" "False" "9.441" "5" "1" "1" "1" "263" "29.4" "10.02" "4.22" "1" "" "non-structural extracellular;other cell component" "" "Pf10159" "79169" "ENSG00000143793" "MMTAG2" "hsa:79169; Q6P5Y0; Q6ZTZ6; Q6ZWA6; Q8IZH3; Q9BU76" "" "Neutrophil degranulation" "1" "0" "0.993" "1.085" "1.494" "1.302" "1.252" "2.101" "2.304" "2.401" "0.982" "60.6" "60.2" "65.8" "90.6" "78.9" "75.9" "127.3" "139.7" "145.5" "59.5" "" "" "" "" "" "" "" "" "" "" "32.1" "33.4" "37.7" "41.7" "42.7" "42.2" "74.9" "76.2" "81.6" "59.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5053375512568543969" "False" "High" "IsMasterProtein" "Q0VDF9" "Heat shock 70 kDa protein 14 OS=Homo sapiens OX=9606 GN=HSPA14 PE=1 SV=1" "0.000" "False" "9.424" "5" "3" "3" "3" "509" "54.8" "5.59" "8.15" "3" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00012" "51182" "ENSG00000187522" "HSPA14" "A8K8F8; B0YIY9; hsa:51182; Q0VDF9; Q9P0X2; Q9UI07" "Parkin-ubiquitin proteasomal system pathway" "Regulation of HSF1-mediated heat shock response" "2" "0" "0.864" "0.919" "1.105" "1.407" "1.278" "1.281" "0.773" "1.113" "7.085" "46.8" "40.4" "43.0" "51.6" "65.8" "59.8" "59.9" "36.2" "52.0" "331.3" "" "" "" "" "" "" "" "" "" "" "24.8" "22.4" "24.6" "23.8" "35.6" "33.2" "35.3" "19.7" "29.2" "331.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7755566090060093643" "False" "High" "IsMasterProtein" "P35914" "Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Homo sapiens OX=9606 GN=HMGCL PE=1 SV=2" "0.000" "False" "9.420" "10" "4" "5" "4" "325" "34.3" "8.54" "14.14" "4" "cell organization and biogenesis;other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00682" "3155" "ENSG00000117305" "HMGCL" "B4DUP4; B7UCC6; D3Y5K7; hsa:3155; P35914; Q6IBC0; Q96FP8" "Amino acid metabolism" "Peroxisomal protein import; Synthesis of Ketone Bodies" "3" "0" "0.955" "0.942" "1.008" "0.990" "1.037" "0.936" "0.965" "0.901" "0.757" "515.2" "491.9" "485.5" "519.3" "510.3" "534.2" "482.1" "497.0" "464.2" "390.0" "" "" "" "" "" "" "" "" "" "" "272.8" "272.7" "278.0" "239.2" "276.1" "297.1" "283.8" "271.3" "260.4" "390.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8454366493935613494" "False" "High" "IsMasterProtein" "P19404" "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFV2 PE=1 SV=2" "0.000" "False" "9.409" "16" "4" "4" "4" "249" "27.4" "8.06" "11.41" "4" "other metabolic processes;transport;developmental processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf01257" "4729" "ENSG00000178127" "NDUFV2" "hsa:4729; P19404; Q9BV41" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "1.054" "1.124" "0.897" "1.083" "0.997" "0.996" "1.099" "1.131" "0.255" "669.1" "705.0" "751.8" "600.1" "725.0" "667.3" "666.6" "735.1" "756.5" "170.5" "" "" "" "" "" "" "" "" "" "" "354.3" "390.9" "430.6" "276.4" "392.3" "371.2" "392.3" "401.3" "424.4" "170.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4220399671961536759" "False" "High" "IsMasterProtein" "Q92918" "Mitogen-activated protein kinase kinase kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP4K1 PE=1 SV=1" "0.000" "False" "9.402" "5" "4" "4" "4" "833" "91.2" "8.34" "8.37" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "other cell component" "kinase activity;other molecular function" "Pf00069, Pf00780" "11184" "ENSG00000104814" "MAP4K1" "hsa:11184; Q92918" "Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Cardiac hypertrophic response; Hepatocyte growth factor receptor signaling; TGF-beta signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Insulin signaling; Modulators of TCR signaling and T cell activation; Pleural mesothelioma; T-cell receptor signaling pathway" "" "14" "0" "1.291" "1.102" "1.259" "1.523" "1.061" "1.091" "1.397" "1.251" "1.963" "44.1" "57.0" "48.6" "55.6" "67.3" "46.8" "48.1" "61.7" "55.2" "86.7" "" "" "" "" "" "" "" "" "" "" "23.4" "31.6" "27.9" "25.6" "36.4" "26.1" "28.3" "33.7" "31.0" "86.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2283450593618715734" "False" "High" "IsMasterProtein" "P41240" "Tyrosine-protein kinase CSK OS=Homo sapiens OX=9606 GN=CSK PE=1 SV=1" "0.000" "False" "9.385" "6" "3" "3" "3" "450" "50.7" "7.06" "8.68" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "1445" "ENSG00000103653" "CSK" "P41240; Q2M3N2; Q6FGZ6" "Integrin-mediated cell adhesion; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton" "Phosphorylation of CD3 and TCR zeta chains; PD-1 signaling; Signaling by BRAF and RAF1 fusions; Negative regulation of FLT3; GAB1 signalosome; Integrin signaling; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; RHOH GTPase cycle; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "18" "0" "1.029" "0.959" "1.051" "1.029" "1.073" "1.089" "0.623" "0.988" "3.969" "140.9" "145.0" "135.1" "148.1" "145.0" "151.2" "153.4" "87.8" "139.1" "559.2" "" "" "" "" "" "" "" "" "" "" "74.6" "80.4" "77.4" "68.2" "78.5" "84.1" "90.3" "47.9" "78.1" "559.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4770714879888361237" "False" "High" "IsMasterProtein" "Q5GLZ8" "Probable E3 ubiquitin-protein ligase HERC4 OS=Homo sapiens OX=9606 GN=HERC4 PE=1 SV=1" "0.000" "False" "9.377" "3" "2" "2" "2" "1057" "118.5" "6.19" "7.30" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00415, Pf00632" "26091" "ENSG00000148634" "HERC4" "hsa:26091; Q5GC98; Q5GC99; Q5GCA0; Q5GLZ8; Q8IXP9; Q9HCH9" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.842" "0.986" "1.356" "1.041" "0.860" "0.816" "1.007" "0.829" "0.849" "58.8" "49.5" "58.0" "79.7" "61.2" "50.6" "48.0" "59.2" "48.7" "49.9" "" "" "" "" "" "" "" "" "" "" "31.1" "27.5" "33.2" "36.7" "33.1" "28.1" "28.2" "32.3" "27.3" "49.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1655251497259487415" "False" "High" "IsMasterProtein" "Q9BV38" "WD repeat-containing protein 18 OS=Homo sapiens OX=9606 GN=WDR18 PE=1 SV=2" "0.000" "False" "9.364" "4" "2" "2" "2" "432" "47.4" "6.70" "6.22" "2" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf00400, Pf14077" "57418" "ENSG00000065268" "WDR18" "hsa:57418; O60390; Q9BV38; Q9BWR2" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "0.992" "1.046" "0.943" "1.024" "0.950" "0.989" "0.938" "1.024" "0.767" "753.4" "747.4" "788.3" "710.3" "771.8" "715.7" "745.4" "706.3" "771.3" "577.6" "" "" "" "" "" "" "" "" "" "" "398.9" "414.4" "451.5" "327.1" "417.6" "398.1" "438.7" "385.5" "432.7" "577.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6660438545085976361" "False" "High" "IsMasterProtein" "Q9BUL5" "PHD finger protein 23 OS=Homo sapiens OX=9606 GN=PHF23 PE=1 SV=1" "0.000" "False" "9.334" "7" "3" "3" "3" "403" "43.8" "5.78" "8.77" "3" "other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13831" "79142" "ENSG00000040633" "PHF23" "A1DZ74; B3KVH8; B4DLK6; D3DTN4; hsa:79142; Q8IZK0; Q96HG7; Q9BUL5; Q9H5X0" "" "" "0" "0" "1.010" "1.051" "1.063" "0.998" "0.961" "1.004" "1.096" "1.022" "0.867" "574.8" "580.3" "603.9" "611.2" "573.4" "552.6" "576.9" "629.9" "587.1" "498.5" "" "" "" "" "" "" "" "" "" "" "304.3" "321.7" "345.8" "281.5" "310.2" "307.4" "339.5" "343.8" "329.4" "498.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5850236467978773586" "False" "High" "IsMasterProtein" "P40692" "DNA mismatch repair protein Mlh1 OS=Homo sapiens OX=9606 GN=MLH1 PE=1 SV=1" "0.000" "False" "9.323" "7" "6" "6" "6" "756" "84.5" "5.72" "12.10" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01119, Pf13589, Pf16413" "4292" "ENSG00000076242" "MLH1" "B4DI13; B4DQ11; E9PCU2; hsa:4292; P40692" "Ovarian infertility; Chromosomal and microsatellite instability in colorectal cancer ; Male infertility; DNA repair pathways, full network; p53 transcriptional gene network; DNA mismatch repair" "TP53 Regulates Transcription of DNA Repair Genes; Meiotic recombination; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MLH1; Defective Mismatch Repair Associated With PMS2" "12" "0" "0.885" "0.968" "1.254" "1.070" "0.959" "1.486" "1.121" "1.394" "4.896" "143.7" "127.2" "139.1" "180.3" "153.8" "137.9" "213.7" "161.2" "200.4" "703.7" "" "" "" "" "" "" "" "" "" "" "76.1" "70.5" "79.7" "83.0" "83.2" "76.7" "125.7" "88.0" "112.4" "703.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5894079024390586831" "False" "High" "IsMasterProtein" "Q9NQ29" "Putative RNA-binding protein Luc7-like 1 OS=Homo sapiens OX=9606 GN=LUC7L PE=1 SV=1" "0.000" "False" "9.321" "5" "2" "2" "2" "371" "43.7" "9.92" "7.61" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03194" "55692" "ENSG00000007392" "LUC7L" "B8ZZ13; hsa:55692; Q96S32; Q9NPH4; Q9NQ29" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.134" "1.051" "0.956" "1.102" "1.158" "1.333" "0.917" "1.356" "4.773" "254.5" "288.6" "267.4" "243.3" "280.5" "294.6" "339.2" "233.3" "345.2" "1214.7" "" "" "" "" "" "" "" "" "" "" "134.7" "160.0" "153.1" "112.1" "151.7" "163.8" "199.6" "127.3" "193.6" "1214.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5585340363182511889" "False" "High" "IsMasterProtein" "Q9HBU6" "Ethanolamine kinase 1 OS=Homo sapiens OX=9606 GN=ETNK1 PE=1 SV=1" "0.000" "False" "9.320" "6" "3" "4" "2" "452" "50.9" "6.54" "12.93" "3" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf01633" "55500" "ENSG00000139163" "ETNK1" "G5E969; hsa:55500; Q9HBU6" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids" "Synthesis of PE" "5" "0" "0.955" "0.975" "1.064" "1.006" "1.025" "0.856" "0.940" "0.940" "0.928" "223.0" "212.9" "217.5" "237.2" "224.5" "228.7" "190.9" "209.7" "209.7" "207.0" "" "" "" "" "" "" "" "" "" "" "118.1" "118.1" "124.5" "109.3" "121.4" "127.2" "112.3" "114.5" "117.6" "207.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8248162455227524541" "False" "High" "IsMasterProtein" "Q92636" "Protein FAN OS=Homo sapiens OX=9606 GN=NSMAF PE=1 SV=2" "0.000" "False" "9.318" "2" "2" "2" "2" "917" "104.3" "6.23" "6.63" "2" "other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00400, Pf02138, Pf02893" "8439" "ENSG00000035681" "NSMAF" "B4DFB0; E9PCH0; hsa:8439; Q8IW26; Q92636" "TNF-alpha signaling pathway; Orexin receptor pathway" "TNFR1-mediated ceramide production" "3" "0" "0.959" "0.946" "0.966" "0.951" "1.028" "1.076" "1.024" "1.077" "1.011" "349.4" "335.3" "330.6" "337.7" "332.2" "359.1" "375.9" "357.9" "376.2" "353.4" "" "" "" "" "" "" "" "" "" "" "185.0" "185.9" "189.3" "155.5" "179.7" "199.8" "221.3" "195.3" "211.0" "353.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4278249940828633973" "False" "High" "IsMasterProtein" "P32321" "Deoxycytidylate deaminase OS=Homo sapiens OX=9606 GN=DCTD PE=1 SV=2" "0.000" "False" "9.310" "15" "3" "6" "3" "178" "20.0" "7.56" "16.07" "3" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00383" "1635" "ENSG00000129187" "DCTD" "B2R836; D3DP49; D3DP50; hsa:1635; P32321; Q5M7Z8; Q9BVD8" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "0.902" "0.937" "1.028" "0.925" "0.896" "0.946" "0.923" "0.847" "0.695" "126.2" "113.8" "118.3" "129.7" "116.8" "113.0" "119.4" "116.5" "106.9" "87.7" "" "" "" "" "" "" "" "" "" "" "66.8" "63.1" "67.7" "59.8" "63.2" "62.9" "70.3" "63.6" "60.0" "87.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7619751379045493323" "False" "High" "IsMasterProtein" "P04062" "Lysosomal acid glucosylceramidase OS=Homo sapiens OX=9606 GN=GBA1 PE=1 SV=3" "0.000" "False" "9.305" "5" "3" "3" "3" "536" "59.7" "7.61" "9.03" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "signal transduction activity or receptor binding;other molecular function" "Pf02055, Pf17189" "2629" "ENSG00000177628" "GBA1" "A8K796; B7Z5G2; B7Z6S1; hsa:2629; J3KQG4; J3KQK9; P04062; Q16545; Q4VX22; Q6I9R6; Q9UMJ8" "Sphingolipid pathway" "Association of TriC/CCT with target proteins during biosynthesis; Glycosphingolipid catabolism" "3" "0" "0.950" "0.982" "0.995" "0.925" "1.008" "1.007" "0.921" "0.855" "0.773" "169.2" "160.7" "166.1" "168.4" "156.5" "170.5" "170.4" "155.9" "144.6" "130.8" "" "" "" "" "" "" "" "" "" "" "89.6" "89.1" "95.1" "77.6" "84.7" "94.9" "100.3" "85.1" "81.1" "130.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4634393773107864734" "False" "High" "IsMasterProtein" "P19474" "E3 ubiquitin-protein ligase TRIM21 OS=Homo sapiens OX=9606 GN=TRIM21 PE=1 SV=1" "0.000" "False" "9.291" "6" "3" "3" "3" "475" "54.1" "6.38" "8.20" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097, Pf00622, Pf00643, Pf13765" "6737" "ENSG00000132109" "TRIM21" "hsa:6737; P19474; Q5XPV5; Q96RF8" "" "Interferon gamma signaling; Antigen processing: Ubiquitination & Proteasome degradation; KEAP1-NFE2L2 pathway; Regulation of innate immune responses to cytosolic DNA; STING mediated induction of host immune responses" "5" "0" "1.017" "0.878" "0.986" "1.115" "0.985" "0.943" "0.658" "0.973" "2.914" "102.8" "104.6" "90.3" "101.3" "114.6" "101.2" "96.9" "67.6" "100.1" "299.6" "" "" "" "" "" "" "" "" "" "" "54.4" "58.0" "51.7" "46.7" "62.0" "56.3" "57.0" "36.9" "56.1" "299.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8788472230308956" "False" "High" "IsMasterProtein" "Q8NCW5" "NAD(P)H-hydrate epimerase OS=Homo sapiens OX=9606 GN=NAXE PE=1 SV=2" "0.000" "False" "9.288" "12" "3" "8" "3" "288" "31.7" "7.66" "21.74" "3" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;mitochondrion;other cell component" "other molecular function" "Pf03853" "128240" "ENSG00000163382" "NAXE" "B4DGY3; hsa:128240; Q496C6; Q5T3I2; Q8NCW5" "" "Nicotinamide salvaging" "1" "0" "1.026" "0.945" "0.829" "0.989" "1.047" "0.783" "0.891" "0.947" "0.556" "800.3" "821.2" "756.1" "663.1" "791.5" "837.7" "626.9" "713.2" "757.7" "444.9" "" "" "" "" "" "" "" "" "" "" "423.8" "455.3" "433.0" "305.4" "428.2" "466.0" "369.0" "389.3" "425.1" "444.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8554271472140898461" "False" "High" "IsMasterProtein" "Q8N584" "Tetratricopeptide repeat protein 39C OS=Homo sapiens OX=9606 GN=TTC39C PE=1 SV=2" "0.000" "False" "9.276" "5" "4" "5" "4" "583" "65.8" "6.99" "12.55" "4" "cell organization and biogenesis;developmental processes" "" "" "Pf10300" "125488" "ENSG00000168234" "TTC39C" "B7WP63; hsa:125488; J3QRR1; Q0VAJ2; Q8N284; Q8N584" "" "" "0" "0" "1.106" "1.142" "1.213" "1.056" "1.210" "1.122" "1.127" "1.129" "0.897" "321.1" "355.0" "366.8" "389.6" "339.1" "388.4" "360.2" "362.0" "362.6" "288.1" "" "" "" "" "" "" "" "" "" "" "170.0" "196.8" "210.1" "179.4" "183.5" "216.1" "212.0" "197.6" "203.4" "288.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2020572113107876671" "False" "High" "IsMasterProtein" "Q13643" "Four and a half LIM domains protein 3 OS=Homo sapiens OX=9606 GN=FHL3 PE=1 SV=4" "0.000" "False" "9.275" "10" "3" "3" "3" "280" "31.2" "6.20" "6.16" "3" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00412" "2275" "ENSG00000183386" "FHL3" "D3DPT6; hsa:2275; Q13643; Q6I9T0; Q9BVA2" "" "" "0" "0" "1.012" "1.157" "1.047" "0.986" "1.134" "0.985" "1.065" "0.970" "0.802" "386.7" "391.3" "447.3" "405.0" "381.4" "438.4" "381.1" "411.7" "375.2" "310.2" "" "" "" "" "" "" "" "" "" "" "204.8" "216.9" "256.2" "186.5" "206.3" "243.9" "224.3" "224.7" "210.5" "310.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5304133680658965036" "False" "High" "IsMasterProtein" "Q16629" "Serine/arginine-rich splicing factor 7 OS=Homo sapiens OX=9606 GN=SRSF7 PE=1 SV=1" "0.000" "False" "9.273" "16" "4" "9" "3" "238" "27.4" "11.82" "15.77" "4" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6432" "ENSG00000115875" "SRSF7" "B4DLU6; G5E9M3; hsa:6432; Q16629; Q564D3" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "7" "1" "1.011" "1.002" "0.965" "0.952" "0.915" "1.006" "0.909" "0.862" "0.759" "668.1" "675.8" "669.5" "644.9" "636.3" "611.5" "672.1" "607.4" "576.2" "507.0" "" "" "" "" "" "" "" "" "" "" "353.8" "374.7" "383.4" "297.0" "344.2" "340.2" "395.6" "331.6" "323.2" "507.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "687508345564059484" "False" "High" "IsMasterProtein" "Q15436" "Protein transport protein Sec23A OS=Homo sapiens OX=9606 GN=SEC23A PE=1 SV=2" "0.000" "False" "9.264" "4" "3" "5" "3" "765" "86.1" "7.08" "10.44" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10484" "ENSG00000100934" "SEC23A" "B2R5P4; B3KXI2; hsa:10484; Q15436; Q8NE16" "Sterol regulatory element-binding proteins (SREBP) signaling" "MHC class II antigen presentation; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; SARS-CoV-2 activates/modulates innate and adaptive immune responses; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF)" "7" "0" "1.002" "1.000" "1.030" "0.978" "0.980" "0.854" "0.809" "1.032" "1.759" "111.0" "111.2" "111.0" "114.2" "108.5" "108.8" "94.7" "89.8" "114.5" "195.1" "" "" "" "" "" "" "" "" "" "" "58.8" "61.7" "63.6" "52.6" "58.7" "60.5" "55.8" "49.0" "64.2" "195.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9144815558027084880" "False" "High" "IsMasterProtein" "Q96FV9" "THO complex subunit 1 OS=Homo sapiens OX=9606 GN=THOC1 PE=1 SV=1" "0.000" "False" "9.261" "6" "4" "5" "4" "657" "75.6" "4.98" "12.54" "4" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00531, Pf11957" "9984" "ENSG00000079134" "THOC1" "B2RBP6; hsa:9984; Q15219; Q64I72; Q64I73; Q96FV9" "" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "3" "0" "0.818" "0.906" "1.111" "0.963" "0.814" "0.908" "0.846" "1.020" "4.905" "116.0" "94.9" "105.1" "128.8" "111.7" "94.4" "105.3" "98.1" "118.3" "568.9" "" "" "" "" "" "" "" "" "" "" "61.4" "52.6" "60.2" "59.3" "60.5" "52.5" "62.0" "53.5" "66.3" "568.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6499977501869587389" "False" "High" "IsMasterProtein" "Q16798" "NADP-dependent malic enzyme, mitochondrial OS=Homo sapiens OX=9606 GN=ME3 PE=1 SV=2" "0.000" "False" "9.259" "3" "2" "3" "1" "604" "67.0" "7.97" "10.58" "2" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00390, Pf03949" "10873" "ENSG00000151376" "ME3" "B7Z6V0; hsa:10873; Q16798; Q8TBJ0" "" "Citric acid cycle (TCA cycle)" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-508494988063673287" "False" "High" "IsMasterProtein" "Q9NXG2" "THUMP domain-containing protein 1 OS=Homo sapiens OX=9606 GN=THUMPD1 PE=1 SV=2" "0.000" "False" "9.248" "7" "3" "4" "3" "353" "39.3" "7.88" "11.25" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf02926" "55623" "ENSG00000066654" "THUMPD1" "hsa:55623; Q9BWC3; Q9NXG2" "" "rRNA modification in the nucleus and cytosol" "1" "0" "1.022" "0.998" "0.944" "0.979" "1.014" "0.962" "1.157" "1.013" "0.536" "685.5" "700.3" "684.0" "647.3" "671.2" "695.1" "659.3" "793.2" "694.3" "367.3" "" "" "" "" "" "" "" "" "" "" "363.0" "388.3" "391.7" "298.1" "363.2" "386.6" "388.0" "433.0" "389.5" "367.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2207555378581959897" "False" "High" "IsMasterProtein" "Q14761" "Protein tyrosine phosphatase receptor type C-associated protein OS=Homo sapiens OX=9606 GN=PTPRCAP PE=1 SV=1" "0.000" "False" "9.225" "11" "2" "2" "2" "206" "21.2" "4.55" "5.63" "2" "stress response" "plasma membrane;other membranes" "" "Pf15713" "5790" "ENSG00000213402" "PTPRCAP" "B2R512; hsa:5790; O00643; Q14761; Q6I9S6" "TNF-alpha signaling pathway" "" "1" "0" "1.097" "1.137" "1.312" "0.945" "1.156" "0.929" "1.069" "1.069" "0.591" "110.8" "121.5" "126.0" "145.4" "104.7" "128.1" "102.9" "118.4" "118.5" "65.5" "" "" "" "" "" "" "" "" "" "" "58.7" "67.4" "72.1" "67.0" "56.7" "71.2" "60.5" "64.7" "66.5" "65.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8102518268723220557" "False" "High" "IsMasterProtein" "Q2M2I8" "AP2-associated protein kinase 1 OS=Homo sapiens OX=9606 GN=AAK1 PE=1 SV=3" "0.000" "False" "9.223" "2" "2" "2" "2" "961" "103.8" "6.60" "6.48" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069" "22848" "ENSG00000115977" "AAK1" "hsa:22848; Q2M2I8; Q4ZFZ3; Q53RX6; Q9UPV4" "" "Cargo recognition for clathrin-mediated endocytosis" "2" "0" "1.224" "1.275" "1.330" "1.196" "1.190" "1.189" "1.201" "1.242" "0.968" "42.7" "52.3" "54.5" "56.9" "51.1" "50.9" "50.8" "51.3" "53.1" "41.4" "" "" "" "" "" "" "" "" "" "" "22.6" "29.0" "31.2" "26.2" "27.7" "28.3" "29.9" "28.0" "29.8" "41.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7361850666082059512" "False" "High" "IsMasterProtein" "P54252" "Ataxin-3 OS=Homo sapiens OX=9606 GN=ATXN3 PE=1 SV=5" "0.000" "False" "9.193" "6" "1" "1" "1" "361" "41.2" "4.78" "4.91" "1" "cell-cell signaling;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02099, Pf02809, Pf16619" "4287" "ENSG00000066427" "ATXN3" "A7LFZ5; D6RDL9; E9PB63; hsa:4287; O15284; O15285; O15286; P54252; Q8N189; Q96TC3; Q96TC4; Q9H3N0" "HDAC6 interactions in the central nervous system" "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Josephin domain DUBs" "3" "0" "1.098" "1.537" "1.659" "1.301" "0.981" "2.339" "1.784" "1.288" "1.958" "16.0" "17.5" "24.5" "26.5" "20.8" "15.7" "37.3" "28.5" "20.5" "31.2" "" "" "" "" "" "" "" "" "" "" "8.4" "9.7" "14.0" "12.2" "11.2" "8.7" "22.0" "15.5" "11.5" "31.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3912553749902594293" "False" "High" "IsMasterProtein" "P15880" "Small ribosomal subunit protein uS5 OS=Homo sapiens OX=9606 GN=RPS2 PE=1 SV=2" "0.000" "False" "9.184" "11" "4" "6" "4" "293" "31.3" "10.24" "12.72" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00333, Pf03719" "6187" "ENSG00000140988; ENSG00000291931" "RPS2" "B2R5G0; D3DU82; hsa:6187; P15880; Q3MIB1" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Protein methylation; Peptide chain elongation; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; RMTs methylate histone arginines; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "22" "0" "1.088" "1.037" "1.251" "1.101" "1.178" "1.231" "1.168" "1.193" "1.790" "313.1" "340.5" "324.8" "391.6" "344.6" "368.7" "385.3" "365.8" "373.4" "560.4" "" "" "" "" "" "" "" "" "" "" "165.8" "188.8" "186.0" "180.3" "186.4" "205.1" "226.8" "199.6" "209.4" "560.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4118942694403519746" "False" "High" "IsMasterProtein" "Q13492" "Phosphatidylinositol-binding clathrin assembly protein OS=Homo sapiens OX=9606 GN=PICALM PE=1 SV=2" "0.000" "False" "9.180" "4" "3" "3" "3" "652" "70.7" "7.90" "8.84" "3" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf07651" "8301" "ENSG00000073921" "PICALM" "B4DTM3; E9PN05; F8VPG7; hsa:8301; O60700; Q13492; Q4LE54; Q6GMQ6; Q86XZ9" "" "Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; RND3 GTPase cycle" "4" "0" "0.962" "0.961" "0.938" "1.045" "1.032" "1.002" "0.994" "1.003" "0.716" "645.0" "620.4" "619.7" "605.1" "673.8" "665.4" "646.2" "641.0" "647.0" "462.1" "" "" "" "" "" "" "" "" "" "" "341.5" "344.0" "354.9" "278.7" "364.5" "370.1" "380.3" "349.9" "363.0" "462.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4229859227879041997" "False" "High" "IsMasterProtein" "P16278" "Beta-galactosidase OS=Homo sapiens OX=9606 GN=GLB1 PE=1 SV=2" "0.000" "False" "9.180" "4" "2" "4" "2" "677" "76.0" "6.57" "5.64" "2" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01301, Pf21317, Pf21467" "2720" "ENSG00000170266" "GLB1" "B2R7H8; B7Z6B0; hsa:2720; P16278; P16279" "Ectoderm differentiation; Degradation pathway of sphingolipids, including diseases; Ciliary landscape; Glycosaminoglycan degradation; Sphingolipid metabolism in senescence" "Neutrophil degranulation; HS-GAG degradation; Sialic acid metabolism; Glycosphingolipid catabolism; Keratan sulfate degradation; Defective NEU1 causes sialidosis; MPS IV - Morquio syndrome B" "12" "0" "1.077" "0.947" "1.190" "1.029" "1.072" "1.069" "1.029" "1.038" "0.959" "184.1" "198.2" "174.4" "219.0" "189.4" "197.3" "196.7" "189.3" "191.0" "176.4" "" "" "" "" "" "" "" "" "" "" "97.5" "109.9" "99.9" "100.9" "102.5" "109.7" "115.7" "103.4" "107.2" "176.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5760294074974619673" "False" "High" "IsMasterProtein" "O95319" "CUGBP Elav-like family member 2 OS=Homo sapiens OX=9606 GN=CELF2 PE=1 SV=1" "0.000" "False" "9.162" "6" "4" "4" "4" "508" "54.3" "8.76" "9.31" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "10659" "ENSG00000048740" "CELF2" "B7ZAN9; O95319; Q7KYU4; Q8N499; Q92950; Q96NW9; Q96RQ5; Q96RQ6; Q9UL67" "mRNA processing; Opioid receptor pathways" "" "2" "0" "0.938" "0.845" "0.892" "0.969" "0.819" "0.779" "0.785" "1.119" "0.892" "277.6" "260.4" "234.5" "247.7" "269.1" "227.4" "216.3" "218.0" "310.8" "247.8" "" "" "" "" "" "" "" "" "" "" "147.0" "144.4" "134.3" "114.1" "145.6" "126.5" "127.3" "119.0" "174.3" "247.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5735228591980069382" "False" "High" "IsMasterProtein" "Q9HD42" "Charged multivesicular body protein 1a OS=Homo sapiens OX=9606 GN=CHMP1A PE=1 SV=1" "0.000" "False" "9.131" "12" "3" "5" "3" "196" "21.7" "8.06" "15.47" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "5119" "ENSG00000131165" "CHMP1A" "A2RU09; hsa:5119; Q14468; Q15779; Q96G31; Q9HD42" "" "HCMV Late Events" "1" "0" "1.129" "1.107" "1.155" "1.126" "1.017" "1.005" "1.037" "1.030" "0.547" "409.6" "462.5" "453.3" "473.2" "461.2" "416.7" "411.7" "424.6" "421.8" "224.1" "" "" "" "" "" "" "" "" "" "" "216.9" "256.4" "259.6" "217.9" "249.5" "231.8" "242.3" "231.8" "236.6" "224.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5712517081782202986" "False" "High" "IsMasterProtein" "Q86V48" "Leucine zipper protein 1 OS=Homo sapiens OX=9606 GN=LUZP1 PE=1 SV=2" "0.000" "False" "9.127" "3" "3" "3" "3" "1076" "120.2" "8.50" "8.53" "3" "developmental processes" "cytoskeleton;nucleus;other cell component" "" "" "7798" "ENSG00000169641" "LUZP1" "hsa:7798; Q5TH93; Q86V48; Q8N4X3; Q8TEH1" "Orexin receptor pathway" "" "1" "0" "1.014" "0.949" "1.043" "1.074" "0.907" "1.219" "1.367" "1.440" "0.880" "211.1" "214.1" "200.3" "220.2" "226.6" "191.4" "257.4" "288.5" "303.9" "185.9" "" "" "" "" "" "" "" "" "" "" "111.8" "118.7" "114.7" "101.4" "122.6" "106.5" "151.5" "157.5" "170.5" "185.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6317068778034787864" "False" "High" "IsMasterProtein" "Q9BTE3" "Mini-chromosome maintenance complex-binding protein OS=Homo sapiens OX=9606 GN=MCMBP PE=1 SV=2" "0.000" "False" "9.102" "4" "3" "4" "3" "642" "72.9" "5.87" "12.97" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf09739" "79892" "ENSG00000197771" "MCMBP" "B3KSP7; hsa:79892; Q6IA56; Q9BTE3; Q9BVT9; Q9H916" "" "" "0" "0" "0.942" "1.002" "0.861" "0.963" "1.019" "0.901" "0.913" "1.030" "3.105" "306.4" "288.7" "306.9" "263.9" "295.0" "312.3" "276.1" "279.7" "315.6" "951.4" "" "" "" "" "" "" "" "" "" "" "162.3" "160.1" "175.8" "121.5" "159.6" "173.7" "162.5" "152.7" "177.0" "951.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5815959030617886930" "False" "High" "IsMasterProtein" "O75167" "Phosphatase and actin regulator 2 OS=Homo sapiens OX=9606 GN=PHACTR2 PE=1 SV=2" "0.000" "False" "9.102" "4" "2" "2" "2" "634" "69.7" "8.16" "6.94" "2" "cell organization and biogenesis" "plasma membrane;other membranes" "enzyme regulator activity;cytoskeletal activity" "Pf02755" "9749" "ENSG00000112419" "PHACTR2" "A6NKP5; A7MCZ5; A8MZC0; B2RWP7; B4DN76; B4DPB5; B4DTH7; hsa:9749; O75167; Q5TFA0; Q68DM2" "" "Platelet degranulation" "1" "0" "1.055" "1.163" "0.978" "1.175" "1.063" "0.942" "1.110" "1.047" "0.541" "279.9" "295.4" "325.7" "273.7" "328.9" "297.7" "263.8" "310.7" "293.0" "151.5" "" "" "" "" "" "" "" "" "" "" "148.2" "163.8" "186.5" "126.0" "178.0" "165.6" "155.3" "169.6" "164.4" "151.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8809739148280005605" "False" "High" "IsMasterProtein" "P46776" "Large ribosomal subunit protein uL15 OS=Homo sapiens OX=9606 GN=RPL27A PE=1 SV=2" "0.000" "False" "9.096" "14" "2" "4" "2" "148" "16.6" "11.00" "12.89" "2" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "other molecular function" "Pf00828" "6157" "ENSG00000166441" "RPL27A" "B2R4B3; hsa:6157; P46776" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Protein hydroxylation; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "0.972" "1.048" "1.161" "1.043" "0.990" "0.904" "0.919" "0.963" "1.115" "299.0" "290.6" "313.4" "347.2" "312.0" "296.2" "270.2" "274.7" "288.0" "333.5" "" "" "" "" "" "" "" "" "" "" "158.3" "161.1" "179.5" "159.9" "168.8" "164.7" "159.0" "149.9" "161.6" "333.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7766499346682965111" "False" "High" "IsMasterProtein" "Q99583" "Max-binding protein MNT OS=Homo sapiens OX=9606 GN=MNT PE=1 SV=1" "0.000" "False" "9.093" "5" "3" "3" "3" "582" "62.3" "8.78" "6.50" "3" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "4335" "ENSG00000070444" "MNT" "A8K6D1; D3DTI7; hsa:4335; Q1ED38; Q99583" "" "" "0" "0" "0.986" "0.983" "1.118" "1.066" "0.994" "1.019" "1.125" "1.114" "1.121" "268.9" "265.3" "264.4" "300.5" "286.5" "267.3" "274.0" "302.4" "299.6" "301.4" "" "" "" "" "" "" "" "" "" "" "142.4" "147.1" "151.4" "138.4" "155.0" "148.7" "161.2" "165.1" "168.0" "301.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7391762605629829309" "False" "High" "IsMasterProtein" "O95801" "Tetratricopeptide repeat protein 4 OS=Homo sapiens OX=9606 GN=TTC4 PE=1 SV=3" "0.000" "False" "9.084" "7" "3" "3" "3" "387" "44.7" "5.60" "7.32" "3" "protein metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf18972" "7268" "ENSG00000243725" "TTC4" "hsa:7268; O95801; Q53Y95; Q5TA96; Q9H3I2" "" "" "0" "0" "1.045" "1.156" "0.995" "1.011" "1.028" "1.175" "0.628" "1.077" "5.054" "310.3" "324.2" "358.6" "308.8" "313.8" "319.0" "364.5" "195.0" "334.0" "1568.0" "" "" "" "" "" "" "" "" "" "" "164.3" "179.8" "205.4" "142.2" "169.8" "177.5" "214.5" "106.4" "187.4" "1568.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8942814265025091180" "False" "High" "IsMasterProtein" "Q86U28" "Iron-sulfur cluster assembly 2 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=ISCA2 PE=1 SV=2" "0.000" "False" "9.082" "13" "2" "4" "2" "154" "16.5" "5.25" "9.89" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf01521" "122961" "ENSG00000165898" "ISCA2" "A6NFF1; A8K3W3; G3V291; hsa:122961; Q86U28; Q8IYZ0; Q96BB2" "" "Mitochondrial iron-sulfur cluster biogenesis" "1" "0" "1.016" "0.939" "1.170" "0.942" "1.041" "1.029" "0.818" "0.856" "0.600" "68.6" "69.7" "64.4" "80.2" "64.6" "71.4" "70.6" "56.1" "58.7" "41.2" "" "" "" "" "" "" "" "" "" "" "36.3" "38.6" "36.9" "37.0" "34.9" "39.7" "41.6" "30.6" "32.9" "41.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5594688980084840223" "False" "High" "IsMasterProtein" "Q63HN8" "E3 ubiquitin-protein ligase RNF213 OS=Homo sapiens OX=9606 GN=RNF213 PE=1 SV=3" "0.000" "False" "9.081" "1" "3" "3" "3" "5207" "591.0" "6.48" "6.46" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00097, Pf20173" "57674" "ENSG00000173821" "RNF213" "C9JCP4; D6RI12; F8WKS1; hsa:57674; Q63HN8; Q658P6; Q69YK7; Q6MZR1; Q8IWF4; Q8IZX1; Q8IZX2; Q8N406; Q8TEU0; Q9H6C9; Q9H6H9; Q9H6P3; Q9H8A9; Q9HCF4; Q9HCL8" "" "Antigen processing: Ubiquitination & Proteasome degradation; Signaling by ALK fusions and activated point mutants; Suppression of apoptosis" "3" "0" "1.363" "1.204" "1.387" "1.235" "1.275" "1.216" "1.054" "1.327" "5.153" "112.7" "153.7" "135.7" "156.3" "139.2" "143.8" "137.1" "118.8" "149.6" "580.9" "" "" "" "" "" "" "" "" "" "" "59.7" "85.2" "77.7" "72.0" "75.3" "80.0" "80.7" "64.8" "83.9" "580.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4559140579210949167" "False" "High" "IsMasterProtein" "P62917" "Large ribosomal subunit protein uL2 OS=Homo sapiens OX=9606 GN=RPL8 PE=1 SV=2" "0.000" "False" "9.074" "10" "3" "3" "3" "257" "28.0" "11.03" "6.36" "3" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00181, Pf03947" "6132" "ENSG00000161016" "RPL8" "A8K094; D3DWN2; hsa:6132; P25120; P62917; Q567Q7; Q969V7; Q9BWQ9" "Cytoplasmic ribosomal proteins" "Protein hydroxylation; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "0.902" "0.913" "1.426" "0.997" "1.000" "0.832" "0.916" "0.879" "0.536" "227.8" "205.5" "208.0" "324.8" "227.1" "227.9" "189.6" "208.6" "200.2" "122.2" "" "" "" "" "" "" "" "" "" "" "120.6" "113.9" "119.1" "149.6" "122.9" "126.8" "111.6" "113.9" "112.3" "122.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4022881073250375863" "False" "High" "IsMasterProtein" "P16455" "Methylated-DNA--protein-cysteine methyltransferase OS=Homo sapiens OX=9606 GN=MGMT PE=1 SV=1" "0.000" "False" "9.069" "6" "1" "1" "1" "207" "21.6" "8.10" "4.34" "1" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01035, Pf02870" "4255" "ENSG00000170430" "MGMT" "P16455; Q5VY78" "Direct reversal repair; DNA repair pathways, full network; p53 transcriptional gene network" "MGMT-mediated DNA damage reversal" "4" "0" "1.060" "1.125" "1.009" "0.947" "1.051" "0.919" "1.140" "0.964" "0.813" "148.9" "157.9" "167.5" "150.2" "141.1" "156.5" "136.8" "169.8" "143.5" "121.0" "" "" "" "" "" "" "" "" "" "" "78.8" "87.5" "95.9" "69.2" "76.3" "87.1" "80.5" "92.7" "80.5" "121.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4178938987355296714" "False" "High" "IsMasterProtein" "P62312" "U6 snRNA-associated Sm-like protein LSm6 OS=Homo sapiens OX=9606 GN=LSM6 PE=1 SV=1" "0.000" "False" "9.053" "43" "4" "6" "4" "80" "9.1" "9.58" "14.81" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01423" "11157" "ENSG00000164167" "LSM6" "hsa:11157; P62312; Q4W5J5; Q9Y4Y8" "" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "2" "0" "1.021" "1.013" "0.935" "1.051" "1.141" "0.996" "1.065" "1.007" "0.508" "706.4" "721.2" "715.5" "660.3" "742.2" "805.9" "703.8" "752.3" "711.5" "358.5" "" "" "" "" "" "" "" "" "" "" "374.0" "399.8" "409.8" "304.1" "401.6" "448.3" "414.2" "410.7" "399.1" "358.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6200383293614890998" "False" "High" "IsMasterProtein" "Q9UK45" "U6 snRNA-associated Sm-like protein LSm7 OS=Homo sapiens OX=9606 GN=LSM7 PE=1 SV=1" "0.000" "False" "9.051" "40" "3" "5" "3" "103" "11.6" "5.27" "10.58" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "51690" "ENSG00000130332" "LSM7" "hsa:51690; Q9UK45" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "3" "0" "1.249" "1.235" "1.120" "0.894" "1.020" "1.062" "1.206" "0.988" "0.515" "46.0" "57.4" "56.7" "51.5" "41.1" "46.9" "48.8" "55.4" "45.4" "23.7" "" "" "" "" "" "" "" "" "" "" "24.3" "31.8" "32.5" "23.7" "22.2" "26.1" "28.7" "30.3" "25.5" "23.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4400715945048607564" "False" "High" "IsMasterProtein" "P17813" "Endoglin OS=Homo sapiens OX=9606 GN=ENG PE=1 SV=2" "0.000" "False" "9.045" "6" "3" "3" "3" "658" "70.5" "6.61" "7.33" "3" "cell adhesion;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "" "2022" "ENSG00000106991" "ENG" "hsa:2022; P17813; Q14248; Q14926; Q5T9C0" "Hypothesized pathways in pathogenesis of cardiovascular disease; VEGFA-VEGFR2 signaling; TGF-beta receptor signaling in skeletal dysplasias; TGF-beta receptor signaling" "" "4" "0" "0.847" "0.789" "1.110" "0.908" "0.999" "1.062" "0.817" "0.873" "0.483" "73.6" "62.4" "58.1" "81.7" "66.9" "73.6" "78.2" "60.2" "64.3" "35.6" "" "" "" "" "" "" "" "" "" "" "39.0" "34.6" "33.3" "37.6" "36.2" "40.9" "46.0" "32.8" "36.1" "35.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6652011194005899795" "False" "High" "IsMasterProtein" "P29083" "General transcription factor IIE subunit 1 OS=Homo sapiens OX=9606 GN=GTF2E1 PE=1 SV=2" "0.000" "False" "9.042" "5" "2" "2" "2" "439" "49.4" "4.82" "2.87" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf02002, Pf08271, Pf11521" "2960" "ENSG00000153767" "GTF2E1" "hsa:2960; P29083; Q16103" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "10" "0" "0.981" "0.932" "0.991" "0.953" "1.064" "0.961" "0.875" "1.094" "2.864" "159.0" "156.0" "148.2" "157.6" "151.4" "169.2" "152.8" "139.1" "173.8" "455.2" "" "" "" "" "" "" "" "" "" "" "84.2" "86.5" "84.9" "72.6" "81.9" "94.1" "89.9" "76.0" "97.5" "455.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2296645769357171248" "False" "High" "IsMasterProtein" "Q4G0J3" "La-related protein 7 OS=Homo sapiens OX=9606 GN=LARP7 PE=1 SV=1" "0.000" "False" "9.042" "4" "2" "2" "2" "582" "66.9" "9.55" "6.65" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf05383, Pf08777" "51574" "ENSG00000174720" "LARP7" "B2ZHN6; hsa:51574; Q3B7A9; Q4G0J3; Q9P1S7; Q9Y3Z8" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.324" "1.327" "1.982" "1.669" "1.489" "1.451" "0.889" "1.091" "2.298" "29.5" "39.0" "39.1" "58.5" "49.2" "43.9" "42.8" "26.2" "32.2" "67.8" "" "" "" "" "" "" "" "" "" "" "15.6" "21.6" "22.4" "26.9" "26.6" "24.4" "25.2" "14.3" "18.1" "67.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3153714913884480543" "False" "High" "IsMasterProtein" "Q8TAE8" "Large ribosomal subunit protein mL64 OS=Homo sapiens OX=9606 GN=GADD45GIP1 PE=1 SV=1" "0.000" "False" "9.041" "15" "3" "3" "3" "222" "25.4" "10.02" "8.41" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "" "Pf10147" "90480" "ENSG00000179271" "GADD45GIP1" "hsa:90480; Q8IVM3; Q8TAE8; Q8TE51; Q969P9; Q9BSM6" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.987" "1.040" "0.977" "0.967" "0.957" "0.981" "0.972" "0.980" "0.766" "423.0" "417.7" "440.0" "413.3" "409.2" "404.9" "415.1" "411.3" "414.7" "323.9" "" "" "" "" "" "" "" "" "" "" "224.0" "231.6" "252.0" "190.4" "221.4" "225.2" "244.3" "224.5" "232.7" "323.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3627252899551957156" "False" "High" "IsMasterProtein" "Q9NSC5" "Homer protein homolog 3 OS=Homo sapiens OX=9606 GN=HOMER3 PE=1 SV=2" "0.000" "False" "9.020" "6" "2" "2" "2" "361" "39.8" "5.45" "5.66" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00568" "9454" "ENSG00000051128" "HOMER3" "B2RA10; E9PCW9; hsa:9454; O14580; O95350; Q9NSB9; Q9NSC0; Q9NSC1; Q9NSC5" "PKC-gamma calcium signaling pathway in ataxia; Cell lineage map for neuronal differentiation" "Neurexins and neuroligins" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8563797319587415269" "False" "High" "IsMasterProtein" "P25208" "Nuclear transcription factor Y subunit beta OS=Homo sapiens OX=9606 GN=NFYB PE=1 SV=2" "0.000" "False" "9.016" "6" "1" "2" "1" "207" "22.8" "4.59" "5.86" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "4801" "ENSG00000120837" "NFYB" "A8K7B9; hsa:4801; P25208; Q96IY8" "" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum stress; ATF6 (ATF6-alpha) activates chaperone genes" "5" "0" "1.161" "1.016" "1.319" "1.291" "0.919" "1.344" "0.974" "1.153" "0.922" "32.3" "37.5" "32.8" "42.6" "41.7" "29.7" "43.4" "31.5" "37.3" "29.8" "" "" "" "" "" "" "" "" "" "" "17.1" "20.8" "18.8" "19.6" "22.6" "16.5" "25.5" "17.2" "20.9" "29.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2753763641550930270" "False" "High" "IsMasterProtein" "Q96NB3" "Zinc finger protein 830 OS=Homo sapiens OX=9606 GN=ZNF830 PE=1 SV=2" "0.000" "False" "9.008" "8" "2" "2" "2" "372" "42.0" "5.31" "5.70" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12874" "91603" "ENSG00000198783" "ZNF830" "hsa:91603; Q96F60; Q96GZ5; Q96NB3; Q9BU38" "17q12 copy number variation syndrome" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "6" "0" "1.165" "1.022" "1.312" "1.051" "0.966" "1.302" "1.059" "0.909" "0.702" "116.5" "135.7" "119.0" "152.8" "122.4" "112.5" "151.7" "123.3" "105.9" "81.8" "" "" "" "" "" "" "" "" "" "" "61.7" "75.2" "68.2" "70.4" "66.2" "62.6" "89.3" "67.3" "59.4" "81.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3564822305630524625" "False" "High" "IsMasterProtein" "Q96M27" "Protein PRRC1 OS=Homo sapiens OX=9606 GN=PRRC1 PE=1 SV=1" "0.000" "False" "9.000" "6" "3" "3" "3" "445" "46.7" "5.83" "7.97" "3" "" "ER/Golgi;other cell component" "other molecular function" "Pf01931" "133619" "ENSG00000164244" "PRRC1" "hsa:133619; Q69YM8; Q7L2U7; Q86Y42; Q8IVJ4; Q8IVL4; Q8NEZ7; Q96AJ3; Q96M27" "" "" "0" "0" "0.928" "0.885" "0.990" "1.039" "0.960" "0.991" "0.956" "0.962" "0.607" "508.0" "471.5" "449.4" "502.9" "528.0" "487.6" "503.6" "485.6" "488.7" "308.6" "" "" "" "" "" "" "" "" "" "" "269.0" "261.4" "257.4" "231.6" "285.7" "271.2" "296.4" "265.0" "274.1" "308.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8657288411045177937" "False" "High" "IsMasterProtein" "O95429" "BAG family molecular chaperone regulator 4 OS=Homo sapiens OX=9606 GN=BAG4 PE=1 SV=1" "0.000" "False" "8.998" "5" "2" "3" "2" "457" "49.6" "5.12" "10.97" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf02179" "9530" "ENSG00000156735" "BAG4" "B4E217; hsa:9530; O95429; O95818" "Oxidative damage response" "Signaling by FGFR1 in disease; Regulation of HSF1-mediated heat shock response; Signaling by plasma membrane FGFR1 fusions; TNF signaling" "5" "0" "0.922" "1.010" "0.969" "1.035" "0.997" "1.093" "1.094" "1.040" "0.945" "372.9" "344.0" "376.6" "361.2" "385.8" "371.9" "407.4" "407.7" "387.9" "352.4" "" "" "" "" "" "" "" "" "" "" "197.4" "190.7" "215.7" "166.3" "208.7" "206.9" "239.8" "222.6" "217.6" "352.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3575991461264525713" "False" "High" "IsMasterProtein" "Q99933" "BAG family molecular chaperone regulator 1 OS=Homo sapiens OX=9606 GN=BAG1 PE=1 SV=4" "0.000" "False" "8.997" "12" "4" "4" "4" "345" "38.8" "7.81" "7.14" "4" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00240, Pf02179" "573" "ENSG00000107262" "BAG1" "hsa:573; O75315; Q14414; Q53H32; Q5VZE8; Q5VZE9; Q5VZF0; Q96TG2; Q99933; Q9Y2V4" "Androgen receptor signaling pathway" "Regulation of HSF1-mediated heat shock response" "2" "0" "1.342" "1.223" "1.212" "1.153" "1.259" "1.235" "1.212" "1.457" "0.921" "130.2" "174.8" "159.2" "157.8" "150.2" "164.0" "160.9" "157.9" "189.7" "120.0" "" "" "" "" "" "" "" "" "" "" "69.0" "96.9" "91.2" "72.7" "81.3" "91.2" "94.7" "86.2" "106.4" "120.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1711766393091945325" "False" "High" "IsMasterProtein" "Q6DKK2" "Tetratricopeptide repeat protein 19, mitochondrial OS=Homo sapiens OX=9606 GN=TTC19 PE=1 SV=4" "0.000" "False" "8.941" "7" "3" "3" "3" "380" "42.4" "5.77" "8.04" "3" "cell cycle OR cell proliferation;cell organization and biogenesis" "other membranes;cytoskeleton;mitochondrion;other cell component" "" "Pf13374, Pf13424" "54902" "ENSG00000011295" "TTC19" "A8MZ52; B3KP62; B4DN65; hsa:54902; Q2M248; Q6DKK2; Q7L3U8; Q9H6G3; Q9NXB2" "Mitochondrial complex III assembly" "" "1" "0" "1.216" "1.094" "1.100" "1.174" "1.181" "0.998" "0.904" "1.099" "2.007" "185.2" "225.2" "202.7" "203.7" "217.5" "218.8" "184.8" "167.4" "203.6" "371.8" "" "" "" "" "" "" "" "" "" "" "98.1" "124.8" "116.1" "93.8" "117.7" "121.7" "108.8" "91.4" "114.2" "371.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3107589471447250441" "False" "High" "IsMasterProtein" "Q9NV06" "DDB1- and CUL4-associated factor 13 OS=Homo sapiens OX=9606 GN=DCAF13 PE=1 SV=2" "0.000" "False" "8.940" "6" "3" "3" "3" "445" "51.4" "9.19" "8.72" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400, Pf04158, Pf08662" "25879" "ENSG00000164934" "DCAF13" "hsa:25879; Q3MII9; Q8NCH8; Q8TC51; Q96JY7; Q9NV06; Q9NZX3" "" "Major pathway of rRNA processing in the nucleolus and cytosol; Neddylation; rRNA modification in the nucleus and cytosol" "3" "0" "1.093" "1.099" "1.128" "1.113" "1.170" "1.164" "1.047" "1.033" "0.720" "189.4" "207.1" "208.2" "213.7" "210.9" "221.6" "220.4" "198.3" "195.7" "136.5" "" "" "" "" "" "" "" "" "" "" "100.3" "114.8" "119.3" "98.4" "114.1" "123.3" "129.7" "108.3" "109.8" "136.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-486365272632798294" "False" "High" "IsMasterProtein" "Q8WUW1" "Protein BRICK1 OS=Homo sapiens OX=9606 GN=BRK1 PE=1 SV=1" "0.000" "False" "8.923" "32" "4" "5" "4" "75" "8.7" "5.45" "14.37" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "" "55845" "ENSG00000254999" "BRK1" "B2R5E2; hsa:55845; Q8WUW1; Q9P082" "Regulation of actin cytoskeleton" "RAC1 GTPase cycle; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle" "8" "0" "1.060" "1.204" "1.042" "0.864" "0.975" "0.985" "1.020" "0.972" "1.005" "565.5" "599.6" "680.9" "589.4" "488.4" "551.2" "556.8" "577.1" "549.5" "568.4" "" "" "" "" "" "" "" "" "" "" "299.4" "332.4" "390.0" "271.4" "264.3" "306.6" "327.7" "315.0" "308.3" "568.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3427861429656696180" "False" "High" "IsMasterProtein" "O95197" "Reticulon-3 OS=Homo sapiens OX=9606 GN=RTN3 PE=1 SV=2" "0.000" "False" "8.919" "3" "3" "6" "3" "1032" "112.5" "4.96" "17.98" "3" "cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component" "" "Pf02453" "10313" "ENSG00000133318" "RTN3" "B3KQS2; B7Z308; B7Z4M0; F5H774; hsa:10313; O95197; Q147U9; Q496K2; Q53GN3; Q59EP0; Q5UEP2; Q6T930; Q7RTM7; Q7RTM8; Q7RTN3" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "Synaptic adhesion-like molecules" "3" "0" "1.030" "0.986" "0.994" "1.007" "1.010" "0.900" "0.895" "0.950" "0.790" "610.7" "629.2" "602.0" "607.0" "615.2" "617.0" "549.8" "546.7" "580.2" "482.6" "" "" "" "" "" "" "" "" "" "" "323.4" "348.8" "344.8" "279.5" "332.9" "343.2" "323.6" "298.4" "325.4" "482.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4849374493010714997" "False" "High" "IsMasterProtein" "Q92673" "Sortilin-related receptor OS=Homo sapiens OX=9606 GN=SORL1 PE=1 SV=2" "0.000" "False" "8.917" "2" "4" "5" "4" "2214" "248.3" "5.55" "11.02" "4" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00041, Pf00057, Pf00058, Pf15901, Pf15902" "6653" "ENSG00000137642" "SORL1" "B2RNX7; hsa:6653; Q92673; Q92856" "" "Amyloid fiber formation" "1" "0" "1.012" "1.005" "1.063" "1.007" "1.065" "1.117" "0.946" "0.946" "0.846" "269.7" "273.1" "271.0" "286.7" "271.6" "287.3" "301.2" "255.2" "255.2" "228.2" "" "" "" "" "" "" "" "" "" "" "142.8" "151.4" "155.2" "132.0" "146.9" "159.8" "177.2" "139.3" "143.2" "228.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4838568104168178339" "False" "High" "IsMasterProtein" "Q8TBC4" "NEDD8-activating enzyme E1 catalytic subunit OS=Homo sapiens OX=9606 GN=UBA3 PE=1 SV=2" "0.000" "False" "8.895" "4" "2" "2" "2" "463" "51.8" "5.45" "6.68" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00899, Pf08825" "9039" "ENSG00000144744" "UBA3" "A6NLB5; A8K027; hsa:9039; O76088; Q8TBC4; Q9NTU3" "Hijack of ubiquitination by SARS-CoV-2" "Antigen processing: Ubiquitination & Proteasome degradation; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Neddylation" "5" "0" "1.035" "0.988" "0.958" "1.060" "1.075" "1.017" "0.899" "0.859" "1.347" "157.7" "163.3" "155.8" "151.1" "167.2" "169.6" "160.5" "141.8" "135.5" "212.5" "" "" "" "" "" "" "" "" "" "" "83.5" "90.5" "89.2" "69.6" "90.5" "94.4" "94.4" "77.4" "76.0" "212.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4412599355076663570" "False" "High" "IsMasterProtein" "Q8WV92" "MIT domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MITD1 PE=1 SV=1" "0.000" "False" "8.895" "9" "2" "2" "2" "249" "29.3" "8.00" "6.09" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04212, Pf16565" "129531" "ENSG00000158411" "MITD1" "hsa:129531; Q69YV0; Q8WV92" "TAR syndrome" "" "1" "0" "0.878" "1.057" "1.027" "0.968" "0.987" "1.069" "1.025" "0.835" "0.829" "138.1" "121.2" "145.9" "141.7" "133.6" "136.3" "147.6" "141.5" "115.3" "114.4" "" "" "" "" "" "" "" "" "" "" "73.1" "67.2" "83.6" "65.3" "72.3" "75.8" "86.8" "77.2" "64.7" "114.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6568070672358433938" "False" "High" "IsMasterProtein" "Q00341" "Vigilin OS=Homo sapiens OX=9606 GN=HDLBP PE=1 SV=3" "0.000" "False" "8.890" "2" "3" "3" "3" "1268" "141.4" "6.87" "5.65" "3" "other metabolic processes;transport" "non-structural extracellular;plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013" "3069" "ENSG00000115677" "HDLBP" "B4DTQ2; E7EM71; hsa:3069; Q00341; Q53QU2; Q9UCY3" "2q37 copy number variation syndrome" "HDL clearance" "2" "0" "1.139" "1.071" "1.144" "1.148" "1.076" "1.078" "0.642" "1.090" "4.093" "121.0" "137.8" "129.5" "138.5" "138.9" "130.2" "130.4" "77.6" "131.9" "495.2" "" "" "" "" "" "" "" "" "" "" "64.1" "76.4" "74.2" "63.8" "75.2" "72.4" "76.8" "42.4" "74.0" "495.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5148486115263509013" "False" "High" "IsMasterProtein" "Q9C0B0" "RING finger protein unkempt homolog OS=Homo sapiens OX=9606 GN=UNK PE=1 SV=2" "0.000" "False" "8.882" "3" "3" "4" "3" "810" "88.0" "6.86" "10.80" "3" "developmental processes;other biological processes" "other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00642, Pf18384" "85451" "ENSG00000132478" "UNK" "hsa:85451; Q9C0B0" "" "" "0" "0" "1.112" "1.045" "1.099" "1.012" "1.090" "1.195" "1.183" "1.435" "2.042" "93.9" "104.4" "98.2" "103.2" "95.0" "102.3" "112.2" "111.1" "134.8" "191.8" "" "" "" "" "" "" "" "" "" "" "49.7" "57.9" "56.2" "47.5" "51.4" "56.9" "66.1" "60.6" "75.6" "191.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4010780836197462310" "False" "High" "IsMasterProtein" "Q15427" "Splicing factor 3B subunit 4 OS=Homo sapiens OX=9606 GN=SF3B4 PE=1 SV=1" "0.000" "False" "8.856" "5" "2" "2" "2" "424" "44.4" "8.56" "5.44" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00076" "10262" "ENSG00000143368" "SF3B4" "hsa:10262; Q15427; Q5SZ63" "mRNA processing; 10q22q23 copy number variation" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4846658872779087383" "False" "High" "IsMasterProtein" "P61964" "WD repeat-containing protein 5 OS=Homo sapiens OX=9606 GN=WDR5 PE=1 SV=1" "0.000" "False" "8.841" "4" "1" "2" "1" "334" "36.6" "8.27" "6.23" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400" "11091" "ENSG00000196363" "WDR5" "hsa:11091; P61964; Q91VA5; Q9NWX7; Q9UGP9" "Pleural mesothelioma; Kleefstra syndrome" "Neddylation; RMTs methylate histone arginines; Formation of WDR5-containing histone-modifying complexes; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; Cardiogenesis" "10" "0" "0.919" "1.074" "0.892" "0.904" "1.103" "1.019" "1.104" "1.229" "1.698" "43.1" "39.6" "46.3" "38.5" "39.0" "47.6" "44.0" "47.7" "53.0" "73.2" "" "" "" "" "" "" "" "" "" "" "22.8" "22.0" "26.5" "17.7" "21.1" "26.5" "25.9" "26.0" "29.7" "73.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4976528031312254709" "False" "High" "IsMasterProtein" "Q92506" "(3R)-3-hydroxyacyl-CoA dehydrogenase OS=Homo sapiens OX=9606 GN=HSD17B8 PE=1 SV=2" "0.000" "False" "8.832" "10" "2" "2" "2" "261" "27.0" "6.54" "5.72" "2" "cell organization and biogenesis;other metabolic processes" "plasma membrane;other membranes;mitochondrion;other cell component" "other molecular function" "Pf13561" "7923" "ENSG00000112474; ENSG00000204228; ENSG00000225312; ENSG00000228357; ENSG00000228712; ENSG00000232357" "HSD17B8" "A6NLX7; hsa:7923; Q5STP7; Q92506; Q9UIQ1" "" "Fatty acyl-CoA biosynthesis" "1" "0" "0.971" "1.080" "1.169" "1.127" "1.069" "1.178" "1.043" "1.087" "0.841" "96.7" "93.9" "104.4" "113.0" "109.1" "103.4" "114.0" "100.9" "105.1" "81.3" "" "" "" "" "" "" "" "" "" "" "51.2" "52.1" "59.8" "52.1" "59.0" "57.5" "67.1" "55.1" "59.0" "81.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4788954663334132438" "False" "High" "IsMasterProtein" "Q9NWX6" "Probable tRNA(His) guanylyltransferase OS=Homo sapiens OX=9606 GN=THG1L PE=1 SV=2" "0.000" "False" "8.826" "9" "2" "2" "2" "298" "34.8" "8.00" "5.96" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response" "other membranes;cytosol;mitochondrion;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf04446, Pf14413" "54974" "ENSG00000113272" "THG1L" "D3DQJ5; hsa:54974; Q53G12; Q7L5R3; Q9H0S2; Q9NWX6" "" "tRNA modification in the nucleus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8095037981369694658" "False" "High" "IsMasterProtein" "P52434" "DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Homo sapiens OX=9606 GN=POLR2H PE=1 SV=4" "0.000" "False" "8.816" "15" "2" "3" "2" "150" "17.1" "4.68" "10.09" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03870" "5437" "ENSG00000163882" "POLR2H" "C9J413; C9JBJ6; C9JCU7; C9JUA8; hsa:5437; P52434; P53802; Q969R0" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "mRNA Splicing - Major Pathway; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; Estrogen-dependent gene expression; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; B-WICH complex positively regulates rRNA expression; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "57" "0" "1.078" "1.143" "1.409" "1.208" "1.109" "1.374" "1.040" "1.226" "2.186" "136.1" "146.6" "155.5" "191.8" "164.3" "150.9" "187.0" "141.5" "166.9" "297.4" "" "" "" "" "" "" "" "" "" "" "72.0" "81.3" "89.0" "88.3" "88.9" "83.9" "110.0" "77.2" "93.6" "297.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1246779234316334068" "False" "High" "IsMasterProtein" "P49773" "Adenosine 5'-monophosphoramidase HINT1 OS=Homo sapiens OX=9606 GN=HINT1 PE=1 SV=2" "0.000" "False" "8.815" "24" "3" "10" "3" "126" "13.8" "6.95" "28.28" "3" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01230" "3094" "ENSG00000169567" "HINT1" "hsa:3094; P49773; Q9H5W8" "" "" "0" "0" "0.954" "1.288" "1.332" "0.879" "0.863" "0.953" "0.939" "0.838" "0.557" "524.2" "499.9" "675.3" "698.1" "460.7" "452.4" "499.3" "492.1" "439.3" "292.0" "" "" "" "" "" "" "" "" "" "" "277.6" "277.2" "386.7" "321.5" "249.3" "251.6" "293.8" "268.6" "246.4" "292.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4658645955564383119" "False" "High" "IsMasterProtein" "Q86Y82" "Syntaxin-12 OS=Homo sapiens OX=9606 GN=STX12 PE=1 SV=1" "0.000" "False" "8.778" "9" "3" "3" "3" "276" "31.6" "5.59" "9.17" "3" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05739, Pf14523" "23673" "ENSG00000117758" "STX12" "B1AJQ7; hsa:23673; O95564; Q86Y82" "" "" "0" "0" "0.972" "1.046" "1.062" "1.127" "1.111" "1.405" "1.494" "1.444" "0.661" "163.2" "158.5" "170.6" "173.3" "183.8" "181.3" "229.2" "243.8" "235.5" "107.9" "" "" "" "" "" "" "" "" "" "" "86.4" "87.9" "97.7" "79.8" "99.5" "100.8" "134.9" "133.1" "132.1" "107.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8651135355279393622" "False" "High" "IsMasterProtein" "Q8N2G8" "GH3 domain-containing protein OS=Homo sapiens OX=9606 GN=GHDC PE=1 SV=2" "0.000" "False" "8.771" "5" "3" "4" "3" "530" "57.5" "7.88" "10.76" "3" "" "non-structural extracellular;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf03321" "84514" "ENSG00000167925" "GHDC" "B4DQS4; E9PDB5; hsa:84514; Q8N2G8; Q9BXM6" "" "Neutrophil degranulation" "1" "0" "0.920" "1.004" "1.015" "1.040" "0.976" "0.941" "0.924" "0.840" "0.667" "371.9" "342.0" "373.3" "377.6" "386.7" "362.9" "349.9" "343.5" "312.3" "248.2" "" "" "" "" "" "" "" "" "" "" "196.9" "189.6" "213.8" "173.9" "209.2" "201.9" "205.9" "187.5" "175.2" "248.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8633785530779633839" "False" "High" "IsMasterProtein" "P49354" "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha OS=Homo sapiens OX=9606 GN=FNTA PE=1 SV=1" "0.000" "False" "8.767" "7" "3" "4" "3" "379" "44.4" "5.08" "11.18" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf01239" "2339" "ENSG00000168522" "FNTA" "A6NJW0; hsa:2339; P49354; Q53XJ9; Q9UDC1" "Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome" "Potential therapeutics for SARS; Inactivation, recovery and regulation of the phototransduction cascade; RAS processing; Apoptotic cleavage of cellular proteins" "9" "0" "1.043" "0.926" "1.069" "1.028" "1.066" "1.053" "1.064" "1.007" "0.954" "441.9" "461.0" "409.2" "472.4" "454.4" "471.3" "465.2" "470.1" "445.1" "421.5" "" "" "" "" "" "" "" "" "" "" "234.0" "255.6" "234.4" "217.5" "245.8" "262.2" "273.8" "256.6" "249.7" "421.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-72385411951020745" "False" "High" "IsMasterProtein" "Q5VUM1" "Succinate dehydrogenase assembly factor 4, mitochondrial OS=Homo sapiens OX=9606 GN=SDHAF4 PE=1 SV=1" "0.000" "False" "8.758" "19" "2" "2" "2" "108" "12.2" "9.36" "6.04" "2" "cell organization and biogenesis;other metabolic processes;stress response" "mitochondrion" "enzyme regulator activity" "Pf07896" "135154" "ENSG00000154079" "SDHAF4" "E1P532; hsa:135154; Q5VUM1" "Mitochondrial complex II assembly" "" "1" "0" "0.920" "1.156" "0.974" "1.017" "0.998" "0.959" "0.929" "0.932" "0.489" "265.5" "244.3" "306.9" "258.7" "270.1" "264.8" "254.7" "246.7" "247.4" "129.8" "" "" "" "" "" "" "" "" "" "" "140.6" "135.4" "175.8" "119.1" "146.1" "147.3" "149.9" "134.7" "138.8" "129.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7583524308725557668" "False" "High" "IsMasterProtein" "Q96J01" "THO complex subunit 3 OS=Homo sapiens OX=9606 GN=THOC3 PE=1 SV=1" "0.000" "False" "8.753" "6" "2" "3" "2" "351" "38.7" "6.09" "5.51" "2" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00400, Pf07676, Pf12894" "84321" "ENSG00000051596" "THOC3" "hsa:84321; Q6NZ53; Q96J01" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "1.070" "1.059" "1.106" "0.958" "1.227" "1.130" "0.975" "1.125" "1.813" "183.6" "196.4" "194.4" "203.0" "175.9" "225.2" "207.4" "178.9" "206.5" "332.9" "" "" "" "" "" "" "" "" "" "" "97.2" "108.9" "111.3" "93.5" "95.2" "125.3" "122.1" "97.7" "115.8" "332.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6115802108714275107" "False" "High" "IsMasterProtein" "P78330" "Phosphoserine phosphatase OS=Homo sapiens OX=9606 GN=PSPH PE=1 SV=2" "0.000" "False" "8.753" "13" "3" "5" "3" "225" "25.0" "5.69" "13.56" "3" "other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00702" "5723" "ENSG00000146733" "PSPH" "B2RCR5; hsa:5723; P78330; Q7Z3S5" "Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells" "Serine biosynthesis" "6" "0" "0.994" "0.978" "0.995" "1.017" "1.007" "1.076" "1.055" "0.965" "0.602" "451.7" "448.9" "441.7" "449.3" "459.5" "455.0" "486.0" "476.6" "435.8" "272.1" "" "" "" "" "" "" "" "" "" "" "239.2" "248.9" "253.0" "206.9" "248.6" "253.1" "286.0" "260.2" "244.5" "272.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5628662921146722487" "False" "High" "IsMasterProtein" "Q9UL18" "Protein argonaute-1 OS=Homo sapiens OX=9606 GN=AGO1 PE=1 SV=3" "0.000" "False" "8.751" "4" "3" "4" "1" "857" "97.2" "9.16" "11.61" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02170, Pf02171, Pf08699, Pf16486, Pf16487, Pf16488" "26523" "ENSG00000092847" "AGO1" "hsa:26523; Q5TA57; Q6P4S0; Q9UL18" "Modulators of TCR signaling and T cell activation" "MAPK6/MAPK4 signaling; TP53 Regulates Metabolic Genes; Transcriptional regulation by small RNAs; Oxidative Stress Induced Senescence; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Ca2+ pathway; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis; Nuclear events stimulated by ALK signaling in cancer; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "23" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1328397515797573102" "False" "High" "IsMasterProtein" "A6NDG6" "Glycerol-3-phosphate phosphatase OS=Homo sapiens OX=9606 GN=PGP PE=1 SV=1" "0.000" "False" "8.746" "9" "3" "3" "3" "321" "34.0" "6.14" "7.23" "3" "other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf13242, Pf13344" "283871" "ENSG00000184207" "PGP" "A6NDG6; hsa:283871" "" "Glycolysis" "1" "0" "0.930" "0.846" "0.904" "0.924" "0.962" "0.980" "0.981" "0.820" "0.487" "130.2" "121.1" "110.2" "117.8" "120.4" "125.4" "127.7" "127.8" "106.7" "63.4" "" "" "" "" "" "" "" "" "" "" "69.0" "67.1" "63.1" "54.2" "65.1" "69.7" "75.1" "69.8" "59.9" "63.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7021380242978739287" "False" "High" "IsMasterProtein" "Q92797" "Symplekin OS=Homo sapiens OX=9606 GN=SYMPK PE=1 SV=2" "0.000" "False" "8.742" "3" "3" "3" "3" "1274" "141.1" "6.13" "4.85" "3" "cell adhesion;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf11935, Pf12295" "8189" "ENSG00000125755" "SYMPK" "hsa:8189; O00521; O00689; O00733; Q59GT5; Q8N2U5; Q92797" "" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "1.806" "1.699" "2.095" "1.477" "2.044" "1.388" "1.357" "1.153" "5.421" "8.4" "15.1" "14.2" "17.5" "12.4" "17.1" "11.6" "11.4" "9.7" "45.4" "" "" "" "" "" "" "" "" "" "" "4.4" "8.4" "8.1" "8.1" "6.7" "9.5" "6.8" "6.2" "5.4" "45.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7469427958651967746" "False" "High" "IsMasterProtein" "Q9GZL7" "Ribosome biogenesis protein WDR12 OS=Homo sapiens OX=9606 GN=WDR12 PE=1 SV=2" "0.000" "False" "8.738" "5" "2" "3" "2" "423" "47.7" "5.90" "10.08" "2" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf08154" "55759" "ENSG00000138442" "WDR12" "B3KPA9; hsa:55759; Q96HU0; Q9GZL7; Q9NV80; Q9NYI8" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.036" "0.971" "1.054" "1.043" "1.080" "1.174" "1.067" "1.030" "0.659" "311.7" "322.9" "302.5" "328.4" "325.1" "336.7" "365.9" "332.5" "321.0" "205.3" "" "" "" "" "" "" "" "" "" "" "165.0" "179.0" "173.2" "151.3" "175.9" "187.3" "215.4" "181.5" "180.0" "205.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-140378452823337742" "False" "High" "IsMasterProtein" "Q9HCN4" "GPN-loop GTPase 1 OS=Homo sapiens OX=9606 GN=GPN1 PE=1 SV=1" "0.000" "False" "8.730" "6" "2" "2" "2" "374" "41.7" "4.92" "5.84" "2" "" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf03029" "11321" "ENSG00000198522" "GPN1" "B4DQJ5; B4DQM4; B4DXU4; B5MBZ5; hsa:11321; O76004; Q9HCN4" "" "" "0" "0" "0.998" "1.051" "0.935" "1.020" "0.911" "0.880" "0.910" "1.007" "1.066" "199.5" "199.1" "209.6" "186.6" "203.5" "181.8" "175.6" "181.6" "200.8" "212.7" "" "" "" "" "" "" "" "" "" "" "105.6" "110.4" "120.0" "85.9" "110.1" "101.1" "103.4" "99.1" "112.7" "212.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1887782222287180929" "False" "High" "IsMasterProtein" "Q9ULV4" "Coronin-1C OS=Homo sapiens OX=9606 GN=CORO1C PE=1 SV=1" "0.000" "False" "8.721" "5" "3" "4" "3" "474" "53.2" "7.08" "10.12" "3" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08953, Pf16300" "23603" "ENSG00000110880" "CORO1C" "A7MAP0; A7MAP1; B3KU12; hsa:23603; Q9NSK5; Q9ULV4" "" "" "0" "0" "1.092" "1.068" "1.232" "1.216" "1.206" "1.109" "1.069" "1.127" "0.747" "107.6" "117.5" "114.9" "132.5" "130.8" "129.7" "119.3" "115.0" "121.2" "80.4" "" "" "" "" "" "" "" "" "" "" "57.0" "65.1" "65.8" "61.0" "70.8" "72.1" "70.2" "62.8" "68.0" "80.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7401329575601911727" "False" "High" "IsMasterProtein" "P13674" "Prolyl 4-hydroxylase subunit alpha-1 OS=Homo sapiens OX=9606 GN=P4HA1 PE=1 SV=2" "0.000" "False" "8.719" "5" "3" "3" "3" "534" "61.0" "6.01" "8.36" "3" "cell organization and biogenesis" "mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf08336, Pf13640" "5033" "ENSG00000122884" "P4HA1" "C9JL12; hsa:5033; P13674; Q15082; Q15083; Q5VSQ5" "Type I collagen synthesis in the context of osteogenesis imperfecta" "Collagen biosynthesis and modifying enzymes" "2" "0" "1.340" "1.390" "1.754" "1.588" "1.414" "1.810" "1.374" "1.496" "3.400" "41.9" "56.2" "58.3" "73.6" "66.6" "59.3" "75.9" "57.6" "62.8" "142.6" "" "" "" "" "" "" "" "" "" "" "22.2" "31.2" "33.4" "33.9" "36.0" "33.0" "44.7" "31.5" "35.2" "142.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4910055014827061803" "False" "High" "IsMasterProtein" "Q14653" "Interferon regulatory factor 3 OS=Homo sapiens OX=9606 GN=IRF3 PE=1 SV=1" "0.000" "False" "8.713" "6" "2" "4" "2" "427" "47.2" "5.34" "6.70" "2" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605, Pf10401" "3661" "ENSG00000126456" "IRF3" "A8K7L2; B2RAZ3; hsa:3661; Q14653; Q5FBY1; Q5FBY2; Q5FBY4; Q7Z5G6" "Apoptosis; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; Fibrin complement receptor 3 signaling pathway; White fat cell differentiation; Ebola virus infection in host; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; STING pathway in Kawasaki-like disease and COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Lung pathology of COVID-19; Urotensin-II-mediated signaling pathway; Induction of autophagy and toll-like receptor signaling pathways by graphene oxide ; Toll-like receptor signaling pathway" "ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; Interferon gamma signaling; Interferon alpha/beta signaling; Negative regulators of DDX58/IFIH1 signaling; TICAM1-dependent activation of IRF3/IRF7; SARS-CoV-1 activates/modulates innate immune responses; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses; Regulation of innate immune responses to cytosolic DNA; IRF3-mediated induction of type I IFN; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; IRF3 mediated activation of type 1 IFN" "38" "0" "1.023" "0.948" "1.104" "1.030" "0.877" "1.023" "0.992" "0.987" "0.925" "497.3" "508.9" "471.6" "548.9" "512.0" "436.0" "508.5" "493.2" "490.9" "459.9" "" "" "" "" "" "" "" "" "" "" "263.3" "282.2" "270.1" "252.8" "277.0" "242.6" "299.3" "269.2" "275.4" "459.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8855179925451267268" "False" "High" "IsMasterProtein" "Q96F24" "Nuclear receptor-binding factor 2 OS=Homo sapiens OX=9606 GN=NRBF2 PE=1 SV=1" "0.000" "False" "8.712" "7" "2" "3" "2" "287" "32.4" "5.87" "5.07" "2" "other metabolic processes;stress response" "other membranes;nucleus;other cytoplasmic organelle;other cell component" "" "Pf08961, Pf17169" "29982" "ENSG00000148572" "NRBF2" "A6PW36; B4DWS0; hsa:29982; Q86UR2; Q96F24; Q96NP6; Q9H0S9; Q9H2I2" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6504309841328491303" "False" "High" "IsMasterProtein" "Q8NAF0" "Zinc finger protein 579 OS=Homo sapiens OX=9606 GN=ZNF579 PE=1 SV=2" "0.000" "False" "8.705" "3" "2" "2" "2" "562" "60.5" "8.69" "7.02" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "163033" "ENSG00000218891" "ZNF579" "hsa:163033; Q8NAF0" "" "" "0" "0" "1.115" "1.028" "1.018" "0.973" "0.854" "1.040" "0.974" "0.954" "1.194" "202.1" "225.4" "207.7" "205.6" "196.5" "172.5" "210.2" "196.8" "192.8" "241.2" "" "" "" "" "" "" "" "" "" "" "107.0" "125.0" "119.0" "94.7" "106.3" "96.0" "123.7" "107.4" "108.2" "241.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8291794919948140528" "False" "High" "IsMasterProtein" "Q14203" "Dynactin subunit 1 OS=Homo sapiens OX=9606 GN=DCTN1 PE=1 SV=3" "0.000" "False" "8.698" "2" "3" "3" "3" "1278" "141.6" "5.81" "8.31" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01302, Pf12455" "1639" "ENSG00000204843" "DCTN1" "A8MY36; B4DM45; E9PFS5; E9PGE1; G5E9H4; hsa:1639; O95296; Q14203; Q6IQ37; Q9BRM9; Q9UIU1; Q9UIU2" "Vasopressin-regulated water reabsorption; HDAC6 interactions in the central nervous system" "Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; XBP1(S) activates chaperone genes" "8" "0" "1.071" "1.214" "1.143" "1.129" "1.074" "1.292" "1.268" "1.361" "3.105" "226.6" "242.7" "275.1" "259.0" "255.7" "243.4" "292.6" "287.3" "308.4" "703.5" "" "" "" "" "" "" "" "" "" "" "120.0" "134.6" "157.5" "119.3" "138.4" "135.4" "172.2" "156.8" "173.0" "703.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5487682516941207466" "False" "High" "IsMasterProtein" "P98171" "Rho GTPase-activating protein 4 OS=Homo sapiens OX=9606 GN=ARHGAP4 PE=1 SV=2" "0.000" "False" "8.689" "4" "3" "3" "3" "946" "105.0" "6.34" "7.42" "3" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00611, Pf00620, Pf14604" "393" "ENSG00000089820" "ARHGAP4" "hsa:393; P98171; Q14144; Q86UY3" "Clock-controlled autophagy in bone metabolism" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2951553745667677229" "False" "High" "IsMasterProtein" "P31689" "DnaJ homolog subfamily A member 1 OS=Homo sapiens OX=9606 GN=DNAJA1 PE=1 SV=2" "0.000" "False" "8.689" "7" "3" "5" "3" "397" "44.8" "7.08" "13.90" "3" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00226, Pf00684, Pf01556" "3301" "ENSG00000086061" "DNAJA1" "hsa:3301; P31689; Q5T7Q0; Q86TL9" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation; HDAC6 interactions in the central nervous system" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" "4" "0" "1.042" "1.094" "0.985" "1.094" "1.169" "1.059" "0.872" "1.160" "2.507" "596.6" "621.8" "652.8" "587.9" "653.0" "697.7" "632.0" "520.2" "692.3" "1495.9" "" "" "" "" "" "" "" "" "" "" "315.9" "344.7" "373.8" "270.7" "353.3" "388.1" "372.0" "284.0" "388.4" "1495.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "75736922320642282" "False" "High" "IsMasterProtein" "O95568" "Histidine protein methyltransferase 1 homolog OS=Homo sapiens OX=9606 GN=METTL18 PE=1 SV=1" "0.000" "False" "8.683" "8" "2" "2" "2" "372" "42.1" "6.76" "5.80" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf13489" "92342" "ENSG00000171806" "METTL18" "B2R9T5; hsa:92342; O95568" "" "" "0" "0" "0.921" "0.581" "0.632" "1.061" "0.778" "1.121" "1.169" "1.017" "0.600" "24.8" "22.8" "14.4" "15.7" "26.3" "19.3" "27.8" "29.0" "25.2" "14.9" "" "" "" "" "" "" "" "" "" "" "13.1" "12.7" "8.2" "7.2" "14.2" "10.7" "16.4" "15.8" "14.1" "14.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5080369595642031285" "False" "High" "IsMasterProtein" "Q9BVG4" "Protein PBDC1 OS=Homo sapiens OX=9606 GN=PBDC1 PE=1 SV=1" "0.000" "False" "8.673" "9" "2" "4" "2" "233" "26.0" "4.79" "9.36" "2" "" "" "" "Pf04669" "51260" "ENSG00000102390" "PBDC1" "hsa:51260; Q9BVG4" "" "" "0" "0" "0.975" "1.151" "1.029" "1.032" "0.915" "1.052" "1.159" "1.106" "1.051" "146.5" "142.8" "168.6" "150.7" "151.2" "134.0" "154.2" "169.7" "162.0" "154.0" "" "" "" "" "" "" "" "" "" "" "77.6" "79.2" "96.6" "69.4" "81.8" "74.5" "90.7" "92.7" "90.9" "154.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4039607230823659526" "False" "High" "IsMasterProtein" "P42025" "Beta-centractin OS=Homo sapiens OX=9606 GN=ACTR1B PE=1 SV=1" "0.000" "False" "8.673" "9" "3" "3" "3" "376" "42.3" "6.40" "8.19" "3" "" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00022" "10120" "ENSG00000115073; ENSG00000291597" "ACTR1B" "D3DVH2; hsa:10120; P42025; Q53SK5; Q9BRB7" "" "Neutrophil degranulation; MHC class II antigen presentation" "2" "0" "1.068" "1.016" "1.097" "1.173" "1.182" "1.089" "1.020" "1.031" "0.790" "197.3" "210.7" "200.4" "216.3" "231.5" "233.1" "214.7" "201.3" "203.3" "155.9" "" "" "" "" "" "" "" "" "" "" "104.5" "116.8" "114.8" "99.6" "125.2" "129.7" "126.4" "109.9" "114.0" "155.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2708632979130541749" "False" "High" "IsMasterProtein" "Cont_P02584" "Profilin-1 OS=Bos taurus OX=9913 GN=PFN1 PE=1 SV=2" "0.000" "True" "8.668" "22" "3" "16" "1" "140" "15.0" "8.28" "30.85" "3" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf00235" "102175326; 104993965; 109573782; 513895" "ENSBGRG00000026249; ENSBIXG00000014601; ENSBIXG00005028693; ENSBTAG00000004915; ENSCHIG00000025972; ENSMMSG00000006925" "PFN1" "A0A212D7Q6; A0A452G587; A0A4W2IHQ6; A0A5N3WG60; A0A5N3X3I9; A0A6B0S5H7; A0A6J0Z611; A0A6P3HSX5; A0A6P5DHW6; A0A8B9YVA5; A0A8C6DAC0; bbis:104993965; biu:109573782; bta:513895; chx:102175326; P02584; Q3ZCH4; Q5E942" "" "PCP/CE pathway; RHO GTPases Activate Formins" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5118939103406682552" "False" "High" "IsMasterProtein" "Q8TEX9" "Importin-4 OS=Homo sapiens OX=9606 GN=IPO4 PE=1 SV=2" "0.000" "False" "8.661" "3" "3" "5" "3" "1081" "118.6" "4.96" "6.12" "3" "transport;other biological processes" "nucleus;other cell component" "other molecular function" "Pf03810, Pf13513" "79711" "ENSG00000196497; ENSG00000285248" "IPO4" "B2RN95; hsa:79711; Q2NL96; Q86TZ9; Q8NCG8; Q8TEX9; Q96SJ3; Q9BTI4; Q9H5L0" "" "" "0" "0" "1.236" "0.993" "1.525" "1.204" "1.183" "1.495" "1.088" "1.342" "4.988" "113.2" "140.0" "112.5" "172.7" "136.3" "134.0" "169.3" "123.3" "152.0" "564.9" "" "" "" "" "" "" "" "" "" "" "60.0" "77.6" "64.4" "79.5" "73.8" "74.5" "99.6" "67.3" "85.3" "564.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7950271419257628424" "False" "High" "IsMasterProtein" "P30049" "ATP synthase subunit delta, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1D PE=1 SV=2" "0.000" "False" "8.658" "5" "1" "4" "1" "168" "17.5" "5.49" "13.37" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity" "Pf02823, Pf21335" "513" "ENSG00000099624" "ATP5F1D" "D6W5Y3; hsa:513; P30049; Q6FG90" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "Cristae formation; Formation of ATP by chemiosmotic coupling" "5" "0" "1.177" "1.173" "1.059" "1.099" "0.975" "1.066" "1.158" "1.098" "0.698" "500.1" "588.5" "586.4" "529.8" "549.6" "487.7" "532.9" "578.9" "549.0" "348.9" "" "" "" "" "" "" "" "" "" "" "264.8" "326.3" "335.8" "244.0" "297.3" "271.3" "313.6" "316.0" "308.0" "348.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2945964816553277045" "False" "High" "IsMasterProtein" "Q9Y2X0" "Mediator of RNA polymerase II transcription subunit 16 OS=Homo sapiens OX=9606 GN=MED16 PE=1 SV=2" "0.000" "False" "8.658" "3" "3" "3" "3" "877" "96.7" "7.37" "8.92" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00400, Pf11635, Pf20718, Pf20719" "10025" "ENSG00000175221" "MED16" "hsa:10025; Q6PJT2; Q96AD4; Q96I35; Q9Y2X0; Q9Y652" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "1.020" "1.025" "1.047" "1.033" "1.096" "1.077" "0.943" "1.051" "1.323" "305.2" "311.5" "313.0" "319.6" "315.3" "334.6" "328.7" "287.7" "320.7" "403.8" "" "" "" "" "" "" "" "" "" "" "161.6" "172.7" "179.2" "147.2" "170.6" "186.1" "193.4" "157.1" "179.9" "403.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8173179408617438185" "False" "High" "IsMasterProtein" "P32929" "Cystathionine gamma-lyase OS=Homo sapiens OX=9606 GN=CTH PE=1 SV=3" "0.000" "False" "8.658" "6" "2" "2" "2" "405" "44.5" "6.70" "7.32" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf01053" "1491" "ENSG00000116761" "CTH" "B4E1R2; E9PDV0; hsa:1491; P32929; Q53FB3; Q53Y79; Q9H4W7; Q9H4W8" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Trans-sulfuration pathway; Trans-sulfuration, one-carbon metabolism and related pathways; Amino acid metabolism; One-carbon metabolism and related pathways; Methionine metabolism leading to sulfur amino acids and related disorders; Ferroptosis" "Degradation of cysteine and homocysteine; Metabolism of ingested SeMet, Sec, MeSec into H2Se; Cysteine formation from homocysteine" "12" "0" "0.934" "0.987" "0.998" "1.016" "1.013" "0.884" "0.960" "0.983" "0.606" "226.4" "211.3" "223.4" "225.9" "230.0" "229.3" "200.1" "217.3" "222.6" "137.2" "" "" "" "" "" "" "" "" "" "" "119.9" "117.2" "127.9" "104.0" "124.4" "127.6" "117.8" "118.6" "124.9" "137.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8622361133611111311" "False" "High" "IsMasterProtein" "O14936" "Peripheral plasma membrane protein CASK OS=Homo sapiens OX=9606 GN=CASK PE=1 SV=3" "0.000" "False" "8.636" "3" "3" "3" "3" "926" "105.1" "6.43" "5.36" "3" "cell adhesion;other metabolic processes;transport;other biological processes" "extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf00595, Pf00625, Pf02828, Pf07653" "8573" "ENSG00000147044" "CASK" "A6NES1; B7ZKY0; hsa:8573; O14936; O43215; Q17RI4; Q59HA0; Q5VT16; Q5VT17; Q5VT18; Q5VT19; Q66T42; Q9BYH6; Q9NYB2; Q9NYB3" "Parkin-ubiquitin proteasomal system pathway; Splicing factor NOVA regulated synaptic proteins; Cell lineage map for neuronal differentiation" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Assembly and cell surface presentation of NMDA receptors; Nephrin family interactions; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle; Syndecan interactions" "10" "0" "1.047" "1.092" "1.090" "1.093" "1.125" "1.179" "1.085" "1.049" "0.917" "360.8" "377.9" "394.0" "393.4" "394.4" "405.9" "425.5" "391.7" "378.6" "330.7" "" "" "" "" "" "" "" "" "" "" "191.1" "209.5" "225.7" "181.2" "213.4" "225.8" "250.4" "213.8" "212.4" "330.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2007854671863603578" "False" "High" "IsMasterProtein" "P46734" "Dual specificity mitogen-activated protein kinase kinase 3 OS=Homo sapiens OX=9606 GN=MAP2K3 PE=1 SV=2" "0.000" "False" "8.634" "7" "3" "3" "2" "347" "39.3" "7.43" "8.11" "3" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5606" "ENSG00000034152" "MAP2K3" "B3KSK7; hsa:5606; P46734; Q99441; Q9UE71; Q9UE72" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Endoderm differentiation; Photodynamic therapy-induced AP-1 survival signaling; TGF-beta signaling pathway; MAPK signaling pathway; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; 16p11.2 proximal deletion syndrome; Pleural mesothelioma; GNAQ pathways in port-wine stain; Interferon type I signaling pathways; Serotonin HTR1 group and FOS pathway; Toll-like receptor signaling pathway" "Oxidative Stress Induced Senescence; activated TAK1 mediates p38 MAPK activation" "34" "0" "1.120" "1.068" "1.205" "1.182" "1.049" "1.225" "0.980" "0.913" "2.092" "122.4" "137.1" "130.8" "147.5" "144.7" "128.5" "150.0" "120.0" "111.8" "256.1" "" "" "" "" "" "" "" "" "" "" "64.8" "76.0" "74.9" "67.9" "78.3" "71.5" "88.3" "65.5" "62.7" "256.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-675276312923681114" "False" "High" "IsMasterProtein" "Q96GY0" "Zinc finger C2HC domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ZC2HC1A PE=1 SV=2" "0.000" "False" "8.631" "8" "3" "4" "3" "325" "35.1" "9.82" "10.40" "3" "" "" "other molecular function" "Pf13913" "51101" "ENSG00000104427" "ZC2HC1A" "hsa:51101; Q96GY0; Q9Y372" "" "" "0" "0" "1.172" "1.172" "1.029" "1.027" "0.991" "1.074" "1.039" "1.075" "0.635" "383.5" "449.3" "449.5" "394.5" "393.8" "380.2" "411.8" "398.4" "412.3" "243.3" "" "" "" "" "" "" "" "" "" "" "203.1" "249.1" "257.4" "181.7" "213.1" "211.5" "242.4" "217.5" "231.3" "243.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7156219127776266862" "False" "High" "IsMasterProtein" "Q9BSE5" "Guanidino acid hydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=AGMAT PE=1 SV=2" "0.000" "False" "8.631" "9" "4" "4" "4" "352" "37.6" "7.59" "10.31" "4" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00491" "79814" "ENSG00000116771" "AGMAT" "hsa:79814; Q5TDH1; Q9BSE5; Q9H5J3" "" "Agmatine biosynthesis" "1" "0" "0.937" "1.008" "0.960" "0.936" "1.038" "0.983" "1.023" "0.963" "0.920" "594.4" "557.0" "599.4" "570.5" "556.4" "617.0" "584.0" "608.2" "572.6" "546.7" "" "" "" "" "" "" "" "" "" "" "314.7" "308.8" "343.3" "262.8" "301.0" "343.2" "343.7" "332.0" "321.2" "546.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9146278248105171304" "False" "High" "IsMasterProtein" "Q6SJ93" "Serine protease FAM111B OS=Homo sapiens OX=9606 GN=FAM111B PE=1 SV=1" "0.000" "False" "8.625" "4" "3" "3" "3" "734" "84.6" "8.59" "3.87" "3" "protein metabolism;DNA metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf13365" "374393" "ENSG00000189057" "FAM111B" "B4E2G2; hsa:374393; Q6P661; Q6SJ93" "" "" "0" "0" "1.130" "0.971" "1.053" "1.076" "1.067" "1.326" "0.686" "0.851" "4.389" "25.3" "28.6" "24.5" "26.6" "27.2" "27.0" "33.5" "17.4" "21.5" "111.0" "" "" "" "" "" "" "" "" "" "" "13.4" "15.8" "14.1" "12.3" "14.7" "15.0" "19.7" "9.5" "12.1" "111.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7020268087964795198" "False" "High" "IsMasterProtein" "Q9Y3B7" "Large ribosomal subunit protein uL11m OS=Homo sapiens OX=9606 GN=MRPL11 PE=1 SV=1" "0.000" "False" "8.600" "18" "3" "3" "3" "192" "20.7" "9.91" "8.72" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00298, Pf03946" "65003" "ENSG00000174547" "MRPL11" "A6NLT0; A8K219; hsa:65003; Q32P46; Q96Q73; Q9Y3B7" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.118" "1.143" "1.058" "1.108" "1.013" "0.927" "0.732" "0.999" "1.661" "122.6" "137.1" "140.1" "129.7" "135.8" "124.3" "113.7" "89.7" "122.5" "203.7" "" "" "" "" "" "" "" "" "" "" "64.9" "76.0" "80.2" "59.7" "73.5" "69.1" "66.9" "49.0" "68.7" "203.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "197200824509217859" "False" "High" "IsMasterProtein" "P31040" "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHA PE=1 SV=2" "0.000" "False" "8.588" "3" "2" "2" "2" "664" "72.6" "7.39" "6.67" "2" "other metabolic processes;developmental processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00890, Pf02910" "6389" "ENSG00000073578" "SDHA" "A8K5J6; B4DJ60; E9PBJ5; hsa:6389; P31040; Q16395; Q59GW8; Q8IW48; Q9UMY5" "Electron transport chain: OXPHOS system in mitochondria; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Nonalcoholic fatty liver disease; Mitochondrial complex II assembly; Arsenic metabolism and reactive oxygen species generation; TCA cycle (aka Krebs or citric acid cycle)" "Respiratory electron transport; Citric acid cycle (TCA cycle)" "9" "0" "0.997" "0.934" "0.991" "1.006" "0.971" "0.961" "0.950" "0.935" "0.491" "381.4" "380.1" "356.2" "377.9" "383.6" "370.3" "366.5" "362.3" "356.8" "187.2" "" "" "" "" "" "" "" "" "" "" "201.9" "210.8" "204.0" "174.1" "207.6" "206.0" "215.7" "197.8" "200.1" "187.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3901447341290801043" "False" "High" "IsMasterProtein" "Q66PJ3" "ADP-ribosylation factor-like protein 6-interacting protein 4 OS=Homo sapiens OX=9606 GN=ARL6IP4 PE=1 SV=3" "0.000" "False" "8.584" "10" "2" "2" "2" "237" "26.4" "10.86" "6.27" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf10500" "51329" "ENSG00000182196" "ARL6IP4" "A4UCR8; B3V0L0; B3V0L1; hsa:51329; Q4F966; Q504R8; Q66PJ3; Q96BI2; Q9NR05; Q9P2R9" "" "" "0" "0" "1.080" "0.953" "1.055" "1.209" "1.051" "1.239" "1.109" "1.267" "0.918" "132.2" "142.9" "126.1" "139.5" "159.8" "139.0" "163.9" "146.7" "167.6" "121.4" "" "" "" "" "" "" "" "" "" "" "70.0" "79.2" "72.2" "64.2" "86.5" "77.3" "96.4" "80.1" "94.0" "121.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-476586099519423561" "False" "High" "IsMasterProtein" "Q9UI43" "rRNA methyltransferase 2, mitochondrial OS=Homo sapiens OX=9606 GN=MRM2 PE=1 SV=1" "0.000" "False" "8.573" "10" "3" "3" "3" "246" "27.4" "9.50" "8.35" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf01728" "29960" "ENSG00000122687" "MRM2" "hsa:29960; Q24JR8; Q9UI43" "" "rRNA modification in the mitochondrion" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9221367924290970171" "False" "High" "IsMasterProtein" "Q07812" "Apoptosis regulator BAX OS=Homo sapiens OX=9606 GN=BAX PE=1 SV=1" "0.000" "False" "8.539" "16" "2" "4" "2" "192" "21.2" "5.22" "9.96" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00452" "581" "ENSG00000087088" "BAX" "A8K4W1; hsa:581; P55269; Q07812; Q07814; Q07815; Q8WZ49; Q9NR76; Q9NYG7; Q9UCZ6; Q9UCZ7; Q9UQD6" "miRNA regulation of DNA damage response; TP53 network; Leptin signaling pathway; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Mammary gland development pathway - Involution (Stage 4 of 4); Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Overview of nanoparticle effects; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced HIF-1 survival signaling; Regulation of apoptosis by parathyroid hormone-related protein; miRNA regulation of p53 pathway in prostate cancer; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Melanoma; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; Peroxiredoxin 2 induced ovarian failure; p53 transcriptional gene network; Pleural mesothelioma; Complement system in neuronal development and plasticity; Urotensin-II-mediated signaling pathway; TROP2 regulatory signaling; IL-26 signaling pathways; HDAC6 interactions in the central nervous system; DNA damage response; DNA damage response (only ATM dependent)" "Release of apoptotic factors from the mitochondria; Pyroptosis; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Transcriptional regulation by RUNX2; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; Activation, translocation and oligomerization of BAX; NTRK3 as a dependence receptor" "48" "0" "1.013" "0.969" "0.987" "0.964" "0.972" "0.802" "0.825" "0.726" "0.624" "452.1" "458.1" "438.2" "446.4" "435.7" "439.3" "362.6" "372.9" "328.3" "282.3" "" "" "" "" "" "" "" "" "" "" "239.4" "254.0" "251.0" "205.6" "235.7" "244.4" "213.4" "203.5" "184.2" "282.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1412779903324820773" "False" "High" "IsMasterProtein" "Q8TF42" "Ubiquitin-associated and SH3 domain-containing protein B OS=Homo sapiens OX=9606 GN=UBASH3B PE=1 SV=2" "0.000" "False" "8.521" "4" "3" "3" "3" "649" "72.6" "6.93" "9.00" "3" "cell adhesion;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00300, Pf00627, Pf14604" "84959" "ENSG00000154127" "UBASH3B" "hsa:84959; Q53GT5; Q53GT8; Q8NBV7; Q8TF42; Q96IG9; Q96NZ2" "" "" "0" "0" "1.048" "0.936" "1.047" "1.065" "1.100" "1.392" "1.122" "1.212" "5.678" "347.5" "364.2" "325.4" "363.9" "370.1" "382.3" "483.9" "389.9" "421.3" "1973.4" "" "" "" "" "" "" "" "" "" "" "184.0" "201.9" "186.3" "167.6" "200.2" "212.7" "284.8" "212.8" "236.3" "1973.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7670404762929313903" "False" "High" "IsMasterProtein" "Q9BYW2" "Histone-lysine N-methyltransferase SETD2 OS=Homo sapiens OX=9606 GN=SETD2 PE=1 SV=3" "0.000" "False" "8.509" "1" "3" "3" "3" "2564" "287.4" "6.14" "7.93" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00397, Pf00856, Pf08236, Pf17907" "29072" "ENSG00000181555" "SETD2" "hsa:29072; O75397; O75405; Q17RW8; Q5BKS9; Q5QGN2; Q69YI5; Q6IN64; Q6ZN53; Q6ZS25; Q8N3R0; Q8TCN0; Q9BYW2; Q9C0D1; Q9H696; Q9NZW9" "Histone modifications; Mesodermal commitment pathway; Mesodermal commitment pathway; Pathways affected in adenoid cystic carcinoma; Clear cell renal cell carcinoma pathways; Type 2 papillary renal cell carcinoma; Pleural mesothelioma" "PKMTs methylate histone lysines" "8" "0" "0.843" "1.074" "1.230" "1.022" "1.179" "1.859" "1.557" "1.581" "1.419" "57.4" "48.4" "61.6" "70.6" "58.7" "67.7" "106.7" "89.3" "90.7" "81.5" "" "" "" "" "" "" "" "" "" "" "30.4" "26.8" "35.3" "32.5" "31.7" "37.7" "62.8" "48.8" "50.9" "81.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "105236357953779316" "False" "High" "IsMasterProtein" "Q9H0R4" "Haloacid dehalogenase-like hydrolase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=HDHD2 PE=1 SV=1" "0.000" "False" "8.499" "10" "2" "3" "2" "259" "28.5" "6.24" "6.59" "2" "other metabolic processes" "" "other molecular function" "Pf13242, Pf13344" "84064" "ENSG00000167220" "HDHD2" "A8K7T3; hsa:84064; Q96NV4; Q9H0R4" "" "" "0" "0" "0.994" "0.771" "0.949" "0.988" "0.908" "1.002" "0.897" "0.922" "0.480" "61.8" "61.5" "47.7" "58.7" "61.1" "56.1" "62.0" "55.5" "57.0" "29.7" "" "" "" "" "" "" "" "" "" "" "32.7" "34.1" "27.3" "27.0" "33.1" "31.2" "36.5" "30.3" "32.0" "29.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8242626749563967556" "False" "High" "IsMasterProtein" "Q9Y606" "Pseudouridylate synthase 1 homolog OS=Homo sapiens OX=9606 GN=PUS1 PE=1 SV=3" "0.000" "False" "8.497" "4" "2" "2" "2" "427" "47.4" "8.41" "6.30" "2" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01416" "80324" "ENSG00000177192" "PUS1" "A8K877; B3KQC1; hsa:80324; Q8WYT2; Q9BU44; Q9Y606" "" "" "0" "0" "1.252" "1.211" "1.693" "1.230" "1.362" "1.324" "0.998" "1.221" "6.069" "165.0" "206.5" "199.8" "279.2" "202.9" "224.6" "218.4" "164.7" "201.4" "1001.2" "" "" "" "" "" "" "" "" "" "" "87.3" "114.5" "114.4" "128.6" "109.8" "125.0" "128.6" "89.9" "113.0" "1001.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3161881869701219173" "False" "High" "IsMasterProtein" "O43715" "TP53-regulated inhibitor of apoptosis 1 OS=Homo sapiens OX=9606 GN=TRIAP1 PE=1 SV=1" "0.000" "False" "8.496" "30" "2" "3" "2" "76" "8.8" "5.48" "7.83" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf05254" "51499" "ENSG00000170855" "TRIAP1" "B2R4Z7; hsa:51499; O43715; Q5RKS5; Q6LCA7" "5q35 copy number variation" "Mitochondrial protein degradation; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release" "3" "0" "0.976" "0.917" "1.192" "1.071" "1.083" "0.951" "1.095" "0.944" "0.834" "143.2" "139.8" "131.3" "170.7" "153.4" "155.1" "136.2" "156.8" "135.2" "119.4" "" "" "" "" "" "" "" "" "" "" "75.8" "77.5" "75.2" "78.6" "83.0" "86.3" "80.1" "85.6" "75.8" "119.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7153575726197497326" "False" "High" "IsMasterProtein" "Q7Z6B0" "Coiled-coil domain-containing protein 91 OS=Homo sapiens OX=9606 GN=CCDC91 PE=1 SV=2" "0.000" "False" "8.490" "7" "4" "4" "4" "441" "49.9" "5.07" "8.55" "4" "transport" "other membranes;cytosol;ER/Golgi;nucleus" "" "" "55297" "ENSG00000123106" "CCDC91" "B3KSA3; C9JR07; hsa:55297; Q68D43; Q6IA78; Q7Z6B0; Q8NEN7; Q9NUW9" "" "" "0" "0" "0.952" "1.024" "0.884" "0.980" "0.996" "1.054" "1.009" "1.054" "0.908" "104.2" "99.1" "106.7" "92.1" "102.1" "103.8" "109.8" "105.1" "109.8" "94.5" "" "" "" "" "" "" "" "" "" "" "55.1" "55.0" "61.1" "42.4" "55.2" "57.7" "64.6" "57.4" "61.6" "94.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8472695818303021401" "False" "High" "IsMasterProtein" "P22087" "rRNA 2'-O-methyltransferase fibrillarin OS=Homo sapiens OX=9606 GN=FBL PE=1 SV=2" "0.000" "False" "8.488" "11" "4" "6" "4" "321" "33.8" "10.18" "10.44" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01269" "2091" "ENSG00000105202; ENSG00000280548" "FBL" "B5BUE8; hsa:2091; O75259; P22087; Q6IAT5; Q9UPI6" "Rubinstein-Taybi syndrome 1" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "3" "0" "1.180" "1.131" "1.223" "1.099" "1.220" "1.217" "1.147" "1.290" "1.069" "182.6" "215.4" "206.5" "223.3" "200.8" "222.9" "222.3" "209.6" "235.5" "195.2" "" "" "" "" "" "" "" "" "" "" "96.7" "119.4" "118.3" "102.8" "108.6" "124.0" "130.8" "114.4" "132.1" "195.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5842118922115640430" "False" "High" "IsMasterProtein" "P36405" "ADP-ribosylation factor-like protein 3 OS=Homo sapiens OX=9606 GN=ARL3 PE=1 SV=2" "0.000" "False" "8.480" "10" "2" "4" "2" "182" "20.4" "7.24" "9.24" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00025" "403" "ENSG00000138175" "ARL3" "B2R6C7; hsa:403; P36405; Q53X83; Q5JSM2" "Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "Trafficking of myristoylated proteins to the cilium" "5" "0" "1.029" "1.177" "1.035" "0.965" "1.022" "1.015" "0.985" "0.857" "0.531" "167.8" "172.6" "197.5" "173.6" "161.9" "171.4" "170.2" "165.3" "143.8" "89.1" "" "" "" "" "" "" "" "" "" "" "88.8" "95.7" "113.1" "79.9" "87.6" "95.4" "100.2" "90.2" "80.7" "89.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6698557715673705148" "False" "High" "IsMasterProtein" "Q6P3W7" "SCY1-like protein 2 OS=Homo sapiens OX=9606 GN=SCYL2 PE=1 SV=1" "0.000" "False" "8.476" "2" "3" "4" "3" "929" "103.6" "8.22" "11.82" "3" "cell-cell signaling;transport;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069" "55681" "ENSG00000136021" "SCYL2" "A8KAB5; hsa:55681; Q6P3W7; Q96EF4; Q96ST4; Q9H7V5; Q9NVH3; Q9P2I7" "" "" "0" "0" "1.092" "1.050" "0.763" "0.931" "1.052" "0.868" "1.026" "1.071" "1.097" "163.0" "177.9" "171.1" "124.3" "151.7" "171.5" "141.4" "167.1" "174.6" "178.8" "" "" "" "" "" "" "" "" "" "" "86.3" "98.6" "98.0" "57.2" "82.1" "95.4" "83.2" "91.2" "97.9" "178.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1923018383904393967" "False" "High" "IsMasterProtein" "Q8TAP6" "Centrosomal protein of 76 kDa OS=Homo sapiens OX=9606 GN=CEP76 PE=1 SV=1" "0.000" "False" "8.468" "4" "2" "2" "2" "659" "74.4" "6.74" "7.38" "2" "other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf15627" "79959" "ENSG00000101624" "CEP76" "B0YJB2; B4DXG5; B4DZW1; hsa:79959; Q658N5; Q8TAP6; Q9H9U7" "Genes related to primary cilium development (based on CRISPR)" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "8" "0" "1.033" "0.984" "1.148" "1.004" "1.067" "0.973" "0.906" "0.968" "0.842" "236.4" "244.2" "232.6" "271.5" "237.3" "252.2" "230.1" "214.3" "229.0" "199.1" "" "" "" "" "" "" "" "" "" "" "125.2" "135.4" "133.2" "125.1" "128.4" "140.3" "135.4" "117.0" "128.5" "199.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2679816748943853066" "False" "High" "IsMasterProtein" "Q9ULH7" "Myocardin-related transcription factor B OS=Homo sapiens OX=9606 GN=MRTFB PE=1 SV=3" "0.000" "False" "8.460" "2" "3" "3" "2" "1088" "118.1" "6.28" "8.12" "3" "other biological processes" "nucleus" "other molecular function" "Pf02037, Pf02755" "57496" "ENSG00000186260" "MRTFB" "A6ND53; B4DGT8; hsa:57496; Q68CT1; Q6UB16; Q86WW2; Q8N226; Q9ULH7" "" "" "0" "0" "0.948" "1.097" "1.030" "1.191" "0.934" "1.342" "1.103" "1.250" "0.827" "39.5" "37.5" "43.4" "40.7" "47.1" "36.9" "53.1" "43.6" "49.4" "32.7" "" "" "" "" "" "" "" "" "" "" "20.9" "20.8" "24.8" "18.8" "25.5" "20.5" "31.2" "23.8" "27.7" "32.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7223228418441482962" "False" "High" "IsMasterProtein" "Q15648" "Mediator of RNA polymerase II transcription subunit 1 OS=Homo sapiens OX=9606 GN=MED1 PE=1 SV=4" "0.000" "False" "8.460" "2" "3" "4" "3" "1581" "168.4" "8.73" "7.56" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf10744" "5469" "ENSG00000125686" "MED1" "A2RRQ6; hsa:5469; O43810; O75447; Q15648; Q6P9H7; Q6PK58; Q9HD39" "Energy metabolism; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Non-genomic actions of 1,25 dihydroxyvitamin D3; 17q12 copy number variation syndrome" "Estrogen-dependent gene expression; Transcriptional activation of mitochondrial biogenesis; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); RORA activates gene expression" "18" "0" "1.001" "1.028" "0.963" "1.020" "1.014" "1.231" "0.871" "1.136" "1.094" "126.4" "126.6" "130.0" "121.8" "128.9" "128.2" "155.6" "110.1" "143.7" "138.3" "" "" "" "" "" "" "" "" "" "" "66.9" "70.2" "74.4" "56.1" "69.8" "71.3" "91.6" "60.1" "80.6" "138.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5318017384069718868" "False" "High" "IsMasterProtein" "Q9Y5B0" "RNA polymerase II subunit A C-terminal domain phosphatase OS=Homo sapiens OX=9606 GN=CTDP1 PE=1 SV=3" "0.000" "False" "8.457" "2" "2" "3" "2" "961" "104.3" "5.27" "9.30" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00533, Pf03031, Pf09309" "9150" "ENSG00000060069" "CTDP1" "A8MY97; hsa:9150; Q7Z644; Q96BZ1; Q9Y5B0; Q9Y6F5" "" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "14" "0" "1.307" "0.976" "1.359" "0.935" "0.990" "1.313" "1.025" "1.295" "4.770" "52.2" "68.2" "50.9" "70.9" "48.8" "51.7" "68.5" "53.5" "67.6" "248.9" "" "" "" "" "" "" "" "" "" "" "27.6" "37.8" "29.2" "32.7" "26.4" "28.7" "40.3" "29.2" "37.9" "248.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6883874888390724890" "False" "High" "IsMasterProtein" "Q5VTL8" "Pre-mRNA-splicing factor 38B OS=Homo sapiens OX=9606 GN=PRPF38B PE=1 SV=1" "0.000" "False" "8.457" "6" "4" "5" "4" "546" "64.4" "10.54" "7.20" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf03371" "55119" "ENSG00000134186" "PRPF38B" "hsa:55119; Q05DD6; Q32Q58; Q5VTL8; Q5VTL9; Q6PK39; Q7Z6E2; Q86WF3; Q8IWG9; Q9NW40" "" "" "0" "0" "1.107" "1.041" "1.183" "1.204" "1.126" "1.213" "1.108" "1.131" "1.148" "459.0" "508.3" "477.7" "542.9" "552.5" "516.7" "556.8" "508.5" "518.9" "526.7" "" "" "" "" "" "" "" "" "" "" "243.0" "281.8" "273.6" "250.0" "298.9" "287.4" "327.7" "277.6" "291.1" "526.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6538585977691412019" "False" "High" "IsMasterProtein" "Q9BYB4" "Guanine nucleotide-binding protein subunit beta-like protein 1 OS=Homo sapiens OX=9606 GN=GNB1L PE=1 SV=2" "0.000" "False" "8.454" "7" "2" "3" "2" "327" "35.6" "7.97" "8.14" "2" "" "" "" "Pf00400" "54584" "ENSG00000185838" "GNB1L" "hsa:54584; Q9BYB4; Q9H2S2; Q9H4M4" "22q11.2 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2160621710341352314" "False" "High" "IsMasterProtein" "O14964" "Hepatocyte growth factor-regulated tyrosine kinase substrate OS=Homo sapiens OX=9606 GN=HGS PE=1 SV=1" "0.000" "False" "8.434" "3" "3" "3" "3" "777" "86.1" "6.16" "8.96" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf01363, Pf12210" "9146" "ENSG00000185359" "HGS" "hsa:9146; O14964; Q9NR36" "TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway" "Endosomal Sorting Complex Required For Transport (ESCRT); Ub-specific processing proteases; Lysosome Vesicle Biogenesis; RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Inhibition of membrane repair; Prevention of phagosomal-lysosomal fusion; RHOBTB3 ATPase cycle" "16" "0" "0.958" "0.964" "0.825" "0.997" "1.036" "1.142" "1.139" "1.167" "1.916" "211.3" "202.6" "203.6" "174.3" "210.8" "218.8" "241.4" "240.7" "246.6" "404.9" "" "" "" "" "" "" "" "" "" "" "111.9" "112.3" "116.6" "80.3" "114.0" "121.7" "142.1" "131.4" "138.3" "404.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4980915021063436064" "False" "High" "IsMasterProtein" "Q9H944" "Mediator of RNA polymerase II transcription subunit 20 OS=Homo sapiens OX=9606 GN=MED20 PE=1 SV=1" "0.000" "False" "8.432" "10" "2" "2" "2" "212" "23.2" "6.87" "5.98" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf08612" "9477" "ENSG00000124641" "MED20" "B4DE08; hsa:9477; O95821; Q5T8J4; Q9H944; Q9Y429" "" "Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; RSV-host interactions; Generic Transcription Pathway" "4" "0" "1.046" "1.164" "1.034" "1.133" "0.961" "1.153" "1.001" "1.006" "1.268" "94.3" "98.7" "109.8" "97.5" "106.9" "90.6" "108.7" "94.5" "94.9" "119.6" "" "" "" "" "" "" "" "" "" "" "49.9" "54.7" "62.9" "44.9" "57.8" "50.4" "64.0" "51.6" "53.2" "119.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4653311583040189549" "False" "High" "IsMasterProtein" "Q9H2P9" "Diphthine methyl ester synthase OS=Homo sapiens OX=9606 GN=DPH5 PE=1 SV=2" "0.000" "False" "8.431" "6" "2" "3" "2" "285" "31.6" "5.31" "9.46" "2" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00590" "51611" "ENSG00000117543" "DPH5" "A8JZY6; D3DT62; hsa:51611; Q9H2P9; Q9P017; Q9P0I4; Q9Y319" "" "Synthesis of diphthamide-EEF2" "1" "0" "0.959" "0.962" "0.878" "0.996" "1.060" "0.925" "1.019" "0.961" "0.536" "566.9" "543.9" "545.4" "497.4" "564.9" "601.1" "524.4" "577.5" "544.8" "303.7" "" "" "" "" "" "" "" "" "" "" "300.2" "301.5" "312.3" "229.1" "305.6" "334.3" "308.6" "315.2" "305.6" "303.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3321226471008760" "False" "High" "IsMasterProtein" "Q9Y2Q3" "Glutathione S-transferase kappa 1 OS=Homo sapiens OX=9606 GN=GSTK1 PE=1 SV=3" "0.000" "False" "8.421" "14" "2" "2" "2" "226" "25.5" "8.41" "5.29" "2" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf01323" "373156" "ENSG00000197448" "GSTK1" "B4DIH1; B4DSY2; hsa:373156; Q6P4H0; Q7Z520; Q9P1S4; Q9Y2Q3" "Metapathway biotransformation Phase I and II" "Peroxisomal protein import; Glutathione conjugation" "3" "0" "1.275" "0.982" "0.827" "0.982" "1.139" "1.026" "0.918" "0.885" "1.311" "76.5" "97.5" "75.1" "63.2" "75.1" "87.1" "78.4" "70.2" "67.7" "100.2" "" "" "" "" "" "" "" "" "" "" "40.5" "54.1" "43.0" "29.1" "40.6" "48.4" "46.2" "38.3" "38.0" "100.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2331175161516182807" "False" "High" "IsMasterProtein" "Q6YN16" "Hydroxysteroid dehydrogenase-like protein 2 OS=Homo sapiens OX=9606 GN=HSDL2 PE=1 SV=1" "0.000" "False" "8.413" "4" "2" "3" "2" "418" "45.4" "7.99" "6.35" "2" "" "mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf00106, Pf02036" "84263" "ENSG00000119471" "HSDL2" "A8K1L4; A8K8X1; A8MSV3; hsa:84263; Q658M8; Q6YN16; Q9BT58" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1394219767961209764" "False" "High" "IsMasterProtein" "Q5T5Y3" "Calmodulin-regulated spectrin-associated protein 1 OS=Homo sapiens OX=9606 GN=CAMSAP1 PE=1 SV=2" "0.000" "False" "8.408" "2" "3" "3" "3" "1602" "177.9" "6.73" "6.66" "3" "cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf08683, Pf11971, Pf17095" "157922" "ENSG00000130559" "CAMSAP1" "A1L4L2; B2REB2; B2REB3; hsa:157922; Q5T5Y3; Q70W33; Q8NCY0; Q96E80; Q96FM3; Q9UFJ5" "" "" "0" "0" "0.922" "1.062" "1.183" "1.230" "1.115" "1.414" "1.118" "1.461" "1.563" "19.5" "17.9" "20.7" "23.0" "24.0" "21.7" "27.5" "21.8" "28.4" "30.4" "" "" "" "" "" "" "" "" "" "" "10.3" "9.9" "11.8" "10.6" "13.0" "12.1" "16.2" "11.9" "16.0" "30.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9172177916429743793" "False" "High" "IsMasterProtein" "Q99816" "Tumor susceptibility gene 101 protein OS=Homo sapiens OX=9606 GN=TSG101 PE=1 SV=2" "0.000" "False" "8.402" "5" "2" "2" "2" "390" "43.9" "6.46" "4.02" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf05743, Pf09454" "7251" "ENSG00000074319" "TSG101" "hsa:7251; Q99816; Q9BUM5" "Ebola virus infection in host; 7q11.23 copy number variation syndrome" "HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy" "7" "0" "0.993" "1.046" "1.098" "1.074" "1.132" "1.159" "0.998" "1.109" "1.880" "409.8" "407.1" "428.7" "450.0" "440.1" "464.0" "474.9" "409.0" "454.4" "770.3" "" "" "" "" "" "" "" "" "" "" "217.0" "225.7" "245.5" "207.3" "238.1" "258.1" "279.5" "223.3" "254.9" "770.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1270194887050037302" "False" "High" "IsMasterProtein" "Q9UBW8" "COP9 signalosome complex subunit 7a OS=Homo sapiens OX=9606 GN=COPS7A PE=1 SV=1" "0.000" "False" "8.402" "9" "3" "3" "3" "275" "30.3" "8.22" "9.39" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01399, Pf18392" "50813" "ENSG00000111652" "COPS7A" "A8K9A6; hsa:50813; Q9NVX3; Q9UBW8; Q9UJW4" "Ciliary landscape" "Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER; Neddylation" "5" "0" "1.054" "0.971" "1.128" "1.109" "1.044" "1.064" "1.085" "0.952" "0.595" "388.7" "409.6" "377.2" "438.4" "431.2" "405.8" "413.6" "421.7" "370.1" "231.2" "" "" "" "" "" "" "" "" "" "" "205.8" "227.1" "216.0" "201.9" "233.3" "225.7" "243.4" "230.2" "207.6" "231.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5117695276373963239" "False" "High" "IsMasterProtein" "Q9UKL0" "REST corepressor 1 OS=Homo sapiens OX=9606 GN=RCOR1 PE=1 SV=2" "0.000" "False" "8.400" "9" "4" "4" "4" "485" "53.3" "7.03" "10.01" "4" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf01448, Pf20878" "23186" "ENSG00000089902" "RCOR1" "hsa:23186; J3KN32; Q15044; Q6P2I9; Q86VG5; Q9UKL0" "" "Potential therapeutics for SARS; Factors involved in megakaryocyte development and platelet production; Regulation of PTEN gene transcription; HDACs deacetylate histones" "4" "0" "1.044" "1.004" "1.056" "1.070" "1.041" "1.017" "0.944" "0.990" "1.886" "199.7" "208.6" "200.5" "210.8" "213.6" "207.9" "203.2" "188.5" "197.7" "376.5" "" "" "" "" "" "" "" "" "" "" "105.7" "115.6" "114.8" "97.1" "115.6" "115.6" "119.6" "102.9" "110.9" "376.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8642503759764886067" "False" "High" "IsMasterProtein" "P49454" "Centromere protein F OS=Homo sapiens OX=9606 GN=CENPF PE=1 SV=3" "0.000" "False" "8.399" "1" "4" "4" "4" "3114" "357.3" "5.10" "7.11" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf10473, Pf10481, Pf10490" "1063" "ENSG00000117724" "CENPF" "hsa:1063; P49454; Q13171; Q13246; Q5VVM7" "Gastric cancer network 1; Ciliopathies" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Polo-like kinase mediated events" "9" "0" "1.056" "1.031" "1.270" "1.138" "1.211" "1.814" "1.788" "1.482" "1.454" "210.1" "221.8" "216.6" "266.7" "239.2" "254.4" "381.1" "375.7" "311.3" "305.6" "" "" "" "" "" "" "" "" "" "" "111.3" "123.0" "124.1" "122.8" "129.4" "141.5" "224.3" "205.1" "174.7" "305.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2868911152044451366" "False" "High" "IsMasterProtein" "Q99570" "Phosphoinositide 3-kinase regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PIK3R4 PE=1 SV=3" "0.000" "False" "8.395" "3" "4" "5" "4" "1358" "153.0" "7.17" "9.39" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00400" "30849" "ENSG00000196455" "PIK3R4" "hsa:30849; Q2TBF4; Q99570" "Alzheimer's disease and miRNA effects; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Neural crest cell migration during development; Neural crest cell migration in cancer; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Osteoblast differentiation and related diseases; Ciliopathies; Insulin signaling; Autophagy; Regulation of actin cytoskeleton; Alzheimer's disease; ADHD and autism (ASD) linked metabolic pathways and SNP; DNA damage response (only ATM dependent)" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; PI3K Cascade; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; RHO GTPases Activate NADPH Oxidases; Toll Like Receptor 9 (TLR9) Cascade" "25" "0" "1.031" "1.051" "0.969" "1.106" "1.116" "0.984" "1.098" "1.041" "1.161" "153.5" "158.3" "161.3" "148.8" "169.8" "171.3" "151.0" "168.6" "159.8" "178.3" "" "" "" "" "" "" "" "" "" "" "81.3" "87.8" "92.4" "68.5" "91.9" "95.3" "88.9" "92.0" "89.6" "178.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1552754402547085825" "False" "High" "IsMasterProtein" "Q5MIZ7" "Serine/threonine-protein phosphatase 4 regulatory subunit 3B OS=Homo sapiens OX=9606 GN=PPP4R3B PE=1 SV=2" "0.000" "False" "8.391" "4" "3" "4" "1" "849" "97.4" "4.96" "9.37" "3" "other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf04802" "57223" "ENSG00000275052" "PPP4R3B" "hsa:57223; Q5MIZ7; Q6P9B0; Q86XB8; Q9BQJ0; Q9BRK2; Q9H913; Q9P2G0" "16p11.2 proximal deletion syndrome" "" "1" "0" "1.479" "1.304" "1.993" "1.236" "1.041" "1.440" "0.743" "0.812" "6.597" "17.3" "25.5" "22.5" "34.4" "21.3" "18.0" "24.9" "12.8" "14.0" "113.9" "" "" "" "" "" "" "" "" "" "" "9.1" "14.2" "12.9" "15.8" "11.5" "10.0" "14.6" "7.0" "7.9" "113.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5399791769626457574" "False" "High" "IsMasterProtein" "Q9UMS0" "NFU1 iron-sulfur cluster scaffold homolog, mitochondrial OS=Homo sapiens OX=9606 GN=NFU1 PE=1 SV=2" "0.000" "False" "8.381" "6" "1" "1" "1" "254" "28.4" "5.07" "5.34" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf01106, Pf08712" "27247" "ENSG00000169599" "NFU1" "B4DUL9; hsa:27247; Q53QE5; Q6VNZ8; Q7Z5B1; Q7Z5B2; Q9UMS0; Q9Y322" "Iron-sulfur cluster biogenesis" "" "1" "0" "0.978" "1.120" "0.914" "1.012" "1.047" "0.997" "1.110" "1.170" "0.584" "222.8" "217.8" "249.4" "203.6" "225.4" "233.2" "222.0" "247.3" "260.7" "130.1" "" "" "" "" "" "" "" "" "" "" "117.9" "120.7" "142.9" "93.8" "122.0" "129.7" "130.7" "135.0" "146.3" "130.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6225223608593832705" "False" "High" "IsMasterProtein" "Q99856" "AT-rich interactive domain-containing protein 3A OS=Homo sapiens OX=9606 GN=ARID3A PE=1 SV=2" "0.000" "False" "8.366" "4" "2" "3" "2" "593" "62.9" "4.91" "5.27" "2" "other biological processes" "other membranes;cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01388" "1820" "ENSG00000116017" "ARID3A" "hsa:1820; Q5I858; Q6P9C6; Q8IZA7; Q8N4Z3; Q99856" "HDAC6 interactions in the central nervous system" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest" "2" "0" "1.185" "1.149" "1.033" "0.950" "1.064" "1.108" "1.328" "1.134" "1.673" "140.1" "166.1" "160.9" "144.8" "133.0" "149.0" "155.2" "186.0" "158.9" "234.4" "" "" "" "" "" "" "" "" "" "" "74.2" "92.1" "92.1" "66.7" "72.0" "82.9" "91.3" "101.5" "89.1" "234.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2858860997982508935" "False" "High" "IsMasterProtein" "Q99757" "Thioredoxin, mitochondrial OS=Homo sapiens OX=9606 GN=TXN2 PE=1 SV=2" "0.000" "False" "8.365" "6" "1" "4" "1" "166" "18.4" "8.29" "9.88" "1" "stress response;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00085" "25828" "ENSG00000100348" "TXN2" "hsa:25828; Q5JZA0; Q6FH60; Q99757; Q9UH29" "Oxidative stress response" "Detoxification of Reactive Oxygen Species; Degradation of cysteine and homocysteine" "3" "0" "1.011" "1.105" "0.990" "1.051" "0.951" "1.011" "0.989" "1.082" "0.703" "219.1" "221.5" "242.0" "216.9" "230.2" "208.3" "221.6" "216.8" "237.1" "154.1" "" "" "" "" "" "" "" "" "" "" "116.0" "122.8" "138.6" "99.9" "124.6" "115.9" "130.4" "118.3" "133.0" "154.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1176830711489117496" "False" "High" "IsMasterProtein" "Q7L1V2" "Vacuolar fusion protein MON1 homolog B OS=Homo sapiens OX=9606 GN=MON1B PE=1 SV=1" "0.000" "False" "8.364" "3" "2" "2" "2" "547" "59.2" "6.29" "5.99" "2" "transport;other biological processes" "other cytoplasmic organelle;other cell component" "" "Pf19036, Pf19037, Pf19038" "22879" "ENSG00000103111" "MON1B" "B4DDZ0; hsa:22879; O94949; Q7L1V2" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-519635040323081051" "False" "High" "IsMasterProtein" "P60953" "Cell division control protein 42 homolog OS=Homo sapiens OX=9606 GN=CDC42 PE=1 SV=2" "0.000" "False" "8.361" "11" "2" "2" "1" "191" "21.2" "6.55" "5.77" "2" "cell-cell signaling;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00071" "998" "ENSG00000070831" "CDC42" "hsa:998; P21181; P25763; P60953; Q7L8R5; Q9UDI2" "Androgen receptor signaling pathway; Target of rapamycin signaling; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Leptin signaling pathway; Microtubule cytoskeleton regulation; Metastatic brain tumor; Pathogenic Escherichia coli infection; RalA downstream regulated genes; B cell receptor signaling pathway; AGE/RAGE pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Focal adhesion; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Oxidative damage response; p38 MAPK signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Hippo signaling regulation pathways; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; Genetic causes of porto-sinusoidal vascular disease; 13q12.12 copy number variation; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "RAC1 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; VEGFA-VEGFR2 Pathway; MAPK6/MAPK4 signaling; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; EPHB-mediated forward signaling; Factors involved in megakaryocyte development and platelet production; CDC42 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; DCC mediated attractive signaling; GPVI-mediated activation cascade; Myogenesis; G beta:gamma signalling through CDC42; EGFR downregulation; RHO GTPases activate PAKs; Inactivation of CDC42 and RAC1; CD28 dependent Vav1 pathway; RHO GTPases activate KTN1" "63" "0" "1.050" "1.143" "0.970" "1.036" "1.257" "0.991" "1.065" "1.114" "0.630" "56.8" "59.6" "64.9" "55.1" "58.8" "71.4" "56.3" "60.5" "63.2" "35.8" "" "" "" "" "" "" "" "" "" "" "30.1" "33.1" "37.2" "25.4" "31.8" "39.7" "33.1" "33.0" "35.5" "35.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4536625609042411990" "False" "High" "IsMasterProtein" "Q16656" "Nuclear respiratory factor 1 OS=Homo sapiens OX=9606 GN=NRF1 PE=1 SV=1" "0.000" "False" "8.361" "4" "2" "3" "2" "503" "53.5" "5.05" "9.27" "2" "other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf10491" "4899" "ENSG00000106459" "NRF1" "A8K4C6; B4DDV6; hsa:4899; Q15305; Q16656; Q96AN2" "Energy metabolism; Interactions between LOXL4 and oxidative stress pathway; Mitochondrial gene expression; Sildenafil treatment" "PPARA activates gene expression; Transcriptional activation of mitochondrial biogenesis" "6" "0" "1.056" "1.043" "1.033" "0.933" "0.985" "0.956" "0.895" "0.953" "1.752" "266.7" "281.7" "278.0" "275.4" "248.9" "262.8" "254.9" "238.8" "254.1" "467.2" "" "" "" "" "" "" "" "" "" "" "141.2" "156.2" "159.2" "126.8" "134.7" "146.2" "150.0" "130.3" "142.5" "467.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6915758716299824080" "False" "High" "IsMasterProtein" "Q06787" "Fragile X messenger ribonucleoprotein 1 OS=Homo sapiens OX=9606 GN=FMR1 PE=1 SV=1" "0.000" "False" "8.352" "4" "3" "3" "2" "632" "71.1" "7.42" "7.58" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function" "Pf00013, Pf05641, Pf12235, Pf16098, Pf17904, Pf18336" "2332" "ENSG00000102081" "FMR1" "A6NNH4; D3DWT0; D3DWT1; D3DWT2; G8JL90; hsa:2332; Q06787; Q16578; Q5PQZ6; Q99054" "Ovarian infertility; Serotonin and anxiety; Prader-Willi and Angelman syndrome; Fragile X syndrome; Disruption of postsynaptic signaling by CNV; 15q11.2 copy number variation syndrome; Primary ovarian insufficiency" "" "7" "1" "1.155" "0.985" "1.133" "1.084" "1.089" "1.229" "0.942" "1.129" "3.824" "144.1" "166.4" "141.9" "163.3" "156.2" "157.0" "177.1" "135.7" "162.7" "551.0" "" "" "" "" "" "" "" "" "" "" "76.3" "92.2" "81.2" "75.2" "84.5" "87.3" "104.2" "74.1" "91.3" "551.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8360736340109521171" "False" "High" "IsMasterProtein" "P57737" "Coronin-7 OS=Homo sapiens OX=9606 GN=CORO7 PE=1 SV=2" "0.000" "False" "8.341" "3" "3" "3" "3" "925" "100.5" "5.80" "9.06" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "cytoskeletal activity" "Pf00400, Pf08953, Pf16300" "79585" "ENSG00000262246; ENSG00000282725" "CORO7" "B4DFD6; B4DL18; hsa:79585; I3L416; P57737; Q17RK4" "" "" "0" "0" "1.061" "0.982" "1.053" "0.987" "0.940" "1.004" "0.654" "1.006" "4.724" "338.6" "359.0" "332.4" "356.6" "334.1" "318.1" "339.9" "221.5" "340.7" "1599.5" "" "" "" "" "" "" "" "" "" "" "179.3" "199.1" "190.3" "164.2" "180.8" "176.9" "200.0" "120.9" "191.1" "1599.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8791134701989231462" "False" "High" "IsMasterProtein" "Q9UQ13" "Leucine-rich repeat protein SHOC-2 OS=Homo sapiens OX=9606 GN=SHOC2 PE=1 SV=2" "0.000" "False" "8.338" "4" "3" "4" "3" "582" "64.8" "8.46" "10.76" "3" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf13855" "8036" "ENSG00000108061" "SHOC2" "A8K9W8; B3KR23; hsa:8036; O76063; Q5VZS8; Q5VZS9; Q9UQ13" "Ras signaling; 22q11.2 copy number variation syndrome; Autophagy in pancreatic ductal adenocarcinoma" "RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling" "6" "0" "1.011" "1.006" "0.918" "0.982" "0.947" "0.968" "0.919" "0.935" "0.840" "432.8" "437.5" "435.4" "397.5" "425.1" "409.7" "418.8" "397.9" "404.8" "363.7" "" "" "" "" "" "" "" "" "" "" "229.2" "242.5" "249.3" "183.1" "230.0" "227.9" "246.5" "217.2" "227.1" "363.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6449517754761536848" "False" "High" "IsMasterProtein" "O95619" "YEATS domain-containing protein 4 OS=Homo sapiens OX=9606 GN=YEATS4 PE=1 SV=1" "0.000" "False" "8.338" "13" "3" "4" "3" "227" "26.5" "8.41" "10.84" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03366" "8089" "ENSG00000127337" "YEATS4" "hsa:8089; O95619; Q9NQD0" "" "HATs acetylate histones; Activation of the TFAP2 (AP-2) family of transcription factors" "2" "0" "1.128" "1.065" "1.064" "1.141" "1.164" "1.096" "1.181" "1.061" "1.324" "380.9" "429.7" "405.8" "405.5" "434.7" "443.5" "417.3" "450.0" "404.1" "504.2" "" "" "" "" "" "" "" "" "" "" "201.7" "238.3" "232.4" "186.7" "235.2" "246.7" "245.6" "245.6" "226.7" "504.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1760362922626917016" "False" "High" "IsMasterProtein" "Q14011" "Cold-inducible RNA-binding protein OS=Homo sapiens OX=9606 GN=CIRBP PE=1 SV=1" "0.000" "False" "8.336" "16" "3" "4" "3" "172" "18.6" "9.51" "11.01" "3" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "1153" "ENSG00000099622" "CIRBP" "B3KT17; B4E2X2; hsa:1153; Q14011" "" "" "0" "0" "1.019" "1.128" "0.856" "0.995" "1.067" "0.880" "1.021" "0.995" "0.599" "286.6" "292.1" "323.2" "245.4" "285.1" "305.8" "252.3" "292.7" "285.1" "171.7" "" "" "" "" "" "" "" "" "" "" "151.7" "162.0" "185.1" "113.0" "154.3" "170.1" "148.5" "159.8" "159.9" "171.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8154313858001218704" "False" "High" "IsMasterProtein" "Q8IWZ3" "Ankyrin repeat and KH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ANKHD1 PE=1 SV=1" "0.000" "False" "8.329" "1" "3" "4" "3" "2542" "269.3" "5.73" "6.76" "3" "stress response" "other cell component" "" "Pf00013, Pf12796, Pf13637" "404734; 54882" "ENSG00000131503" "ANKHD1" "A6NH85; hsa:404734; hsa:54882; Q149P2; Q8IWZ2; Q8IWZ3; Q8WY90; Q96G77; Q96GK0; Q9H2U0; Q9HA95; Q9NWG4; Q9UPR7" "" "" "0" "0" "1.176" "0.959" "1.828" "1.501" "1.107" "1.493" "0.975" "1.184" "4.216" "31.1" "36.6" "29.8" "56.9" "46.7" "34.4" "46.4" "30.3" "36.8" "131.1" "" "" "" "" "" "" "" "" "" "" "16.5" "20.3" "17.1" "26.2" "25.3" "19.1" "27.3" "16.6" "20.7" "131.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5802267777781672264" "False" "High" "IsMasterProtein" "O43665" "Regulator of G-protein signaling 10 OS=Homo sapiens OX=9606 GN=RGS10 PE=1 SV=3" "0.000" "False" "8.328" "9" "1" "1" "1" "181" "21.2" "7.49" "5.91" "1" "cell-cell signaling;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00615" "6001" "ENSG00000148908" "RGS10" "A8K408; B1AMR8; hsa:6001; O43665; Q6IAZ6; Q96GN0" "Mesodermal commitment pathway; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells" "G alpha (i) signalling events" "4" "0" "1.003" "1.039" "0.842" "0.977" "0.923" "0.676" "0.726" "0.791" "0.786" "158.7" "159.2" "165.0" "133.6" "155.0" "146.5" "107.2" "115.3" "125.6" "124.8" "" "" "" "" "" "" "" "" "" "" "84.1" "88.3" "94.5" "61.5" "83.9" "81.5" "63.1" "62.9" "70.5" "124.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8611870974223822516" "False" "High" "IsMasterProtein" "Q8NHP8" "Putative phospholipase B-like 2 OS=Homo sapiens OX=9606 GN=PLBD2 PE=1 SV=2" "0.000" "False" "8.328" "5" "3" "3" "3" "589" "65.4" "6.80" "7.40" "3" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle" "other molecular function" "Pf04916" "196463" "ENSG00000151176" "PLBD2" "F5H5E2; hsa:196463; Q8NHP8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5634316393020217319" "False" "High" "IsMasterProtein" "Q5VZE5" "N-alpha-acetyltransferase 35, NatC auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA35 PE=1 SV=1" "0.000" "False" "8.305" "4" "3" "3" "3" "725" "83.6" "7.05" "5.43" "3" "cell cycle OR cell proliferation;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf04112" "60560" "ENSG00000135040" "NAA35" "hsa:60560; Q5VZE5; Q5VZE6; Q9H631; Q9H703" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "0.943" "0.955" "0.988" "0.925" "0.940" "0.829" "0.796" "0.734" "0.920" "244.8" "230.8" "233.8" "241.8" "226.5" "230.1" "203.0" "194.8" "179.6" "225.2" "" "" "" "" "" "" "" "" "" "" "129.6" "128.0" "133.9" "111.4" "122.6" "128.0" "119.5" "106.3" "100.8" "225.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6008736440558391918" "False" "High" "IsMasterProtein" "O75157" "TSC22 domain family protein 2 OS=Homo sapiens OX=9606 GN=TSC22D2 PE=1 SV=3" "0.000" "False" "8.303" "4" "3" "4" "2" "780" "79.2" "5.02" "9.20" "3" "stress response;other biological processes" "" "" "Pf01166" "9819" "ENSG00000196428" "TSC22D2" "D3DNI5; hsa:9819; O75157; Q6PI50; Q9H2Z6; Q9H2Z7; Q9H2Z8" "" "" "0" "0" "1.178" "1.255" "1.389" "1.312" "1.278" "1.274" "1.181" "1.074" "0.919" "51.6" "60.7" "64.7" "71.6" "67.7" "65.9" "65.7" "60.9" "55.4" "47.4" "" "" "" "" "" "" "" "" "" "" "27.3" "33.7" "37.1" "33.0" "36.6" "36.7" "38.7" "33.2" "31.1" "47.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5163980209620091115" "False" "High" "IsMasterProtein" "O43598" "5-hydroxymethyl-dUMP N-hydrolase OS=Homo sapiens OX=9606 GN=DNPH1 PE=1 SV=1" "0.000" "False" "8.303" "20" "3" "6" "3" "174" "19.1" "5.05" "14.19" "3" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05014" "10591" "ENSG00000112667" "DNPH1" "B2LUJ9; hsa:10591; O43598" "" "Purine catabolism" "1" "0" "0.989" "0.929" "0.910" "0.805" "0.859" "0.800" "0.929" "0.844" "0.416" "784.5" "776.1" "729.0" "713.9" "631.6" "674.1" "627.4" "729.2" "662.1" "326.3" "" "" "" "" "" "" "" "" "" "" "415.4" "430.3" "417.5" "328.8" "341.7" "374.9" "369.3" "398.0" "371.4" "326.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4240907950946080993" "False" "High" "IsMasterProtein" "Q9BV44" "tRNA (guanine(6)-N2)-methyltransferase THUMP3 OS=Homo sapiens OX=9606 GN=THUMPD3 PE=1 SV=1" "0.000" "False" "8.302" "3" "2" "2" "2" "507" "57.0" "6.37" "6.88" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01170, Pf02926" "25917" "ENSG00000134077" "THUMPD3" "hsa:25917; Q9BV44; Q9H8V6; Q9NVC1; Q9UFS3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8494127544242029271" "False" "High" "IsMasterProtein" "P62249" "Small ribosomal subunit protein uS9 OS=Homo sapiens OX=9606 GN=RPS16 PE=1 SV=2" "0.000" "False" "8.296" "16" "3" "4" "3" "146" "16.4" "10.21" "10.88" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00380" "6217" "ENSG00000105193" "RPS16" "B2RDD5; hsa:6217; P17008; P62249" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "19" "0" "1.089" "1.194" "1.161" "1.149" "1.338" "1.314" "1.130" "1.587" "2.122" "511.5" "557.2" "610.6" "594.1" "587.6" "684.3" "672.0" "578.3" "811.7" "1085.3" "" "" "" "" "" "" "" "" "" "" "270.9" "309.0" "349.7" "273.6" "317.9" "380.6" "395.5" "315.7" "455.3" "1085.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5703778072310238355" "False" "High" "IsMasterProtein" "Q9Y6I3" "Epsin-1 OS=Homo sapiens OX=9606 GN=EPN1 PE=1 SV=2" "0.000" "False" "8.293" "5" "2" "3" "2" "576" "60.3" "4.83" "8.16" "2" "transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf01417" "29924" "ENSG00000063245" "EPN1" "hsa:29924; Q86ST3; Q9HA18; Q9Y6I3" "VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation" "5" "0" "0.873" "0.790" "0.893" "0.923" "1.062" "0.937" "0.832" "0.861" "1.094" "106.7" "93.2" "84.3" "95.3" "98.5" "113.3" "100.0" "88.8" "91.9" "116.7" "" "" "" "" "" "" "" "" "" "" "56.5" "51.7" "48.3" "43.9" "53.3" "63.0" "58.8" "48.5" "51.5" "116.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8905060599663970094" "False" "High" "IsMasterProtein" "Q9Y5K8" "V-type proton ATPase subunit D OS=Homo sapiens OX=9606 GN=ATP6V1D PE=1 SV=1" "0.000" "False" "8.282" "7" "2" "2" "2" "247" "28.2" "9.36" "7.46" "2" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity" "Pf01813" "51382" "ENSG00000100554" "ATP6V1D" "B2RE33; hsa:51382; Q9Y5K8; Q9Y688" "Proximal tubule transport" "Neutrophil degranulation; Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "7" "0" "1.035" "0.976" "0.976" "0.978" "1.032" "0.954" "0.990" "1.000" "0.644" "335.9" "347.7" "328.0" "327.9" "328.6" "346.6" "320.4" "332.6" "336.1" "216.5" "" "" "" "" "" "" "" "" "" "" "177.9" "192.8" "187.8" "151.0" "177.8" "192.8" "188.6" "181.5" "188.5" "216.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8505612402410571852" "False" "High" "IsMasterProtein" "P17900" "Ganglioside GM2 activator OS=Homo sapiens OX=9606 GN=GM2A PE=1 SV=4" "0.000" "False" "8.278" "9" "2" "2" "2" "193" "20.8" "5.31" "5.62" "2" "other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;enzyme regulator activity;other molecular function" "Pf02221" "2760" "ENSG00000196743" "GM2A" "B2R699; D3DQH6; hsa:2760; P17900; Q14426; Q14428; Q6LBL5" "Degradation pathway of sphingolipids, including diseases" "Neutrophil degranulation; Glycosphingolipid catabolism" "3" "0" "1.007" "1.074" "0.963" "1.003" "1.036" "1.042" "1.091" "1.071" "0.662" "208.9" "210.3" "224.3" "201.2" "209.6" "216.4" "217.6" "227.9" "223.8" "138.3" "" "" "" "" "" "" "" "" "" "" "110.6" "116.6" "128.5" "92.7" "113.4" "120.4" "128.1" "124.4" "125.5" "138.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8306155883597695001" "False" "High" "IsMasterProtein" "Q9NTM9" "Copper homeostasis protein cutC homolog OS=Homo sapiens OX=9606 GN=CUTC PE=1 SV=1" "0.000" "False" "8.273" "10" "3" "5" "3" "273" "29.3" "8.18" "13.77" "3" "cell organization and biogenesis;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03932" "51076" "ENSG00000119929" "CUTC" "hsa:51076; Q5TCZ8; Q9NTM9; Q9Y321" "" "Ion transport by P-type ATPases" "1" "0" "1.001" "0.963" "1.012" "1.090" "0.939" "1.111" "0.940" "1.041" "0.669" "279.9" "280.4" "269.6" "283.4" "305.2" "262.9" "311.0" "263.2" "291.4" "187.4" "" "" "" "" "" "" "" "" "" "" "148.2" "155.4" "154.4" "130.5" "165.1" "146.2" "183.0" "143.7" "163.4" "187.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5760728246443025630" "False" "High" "IsMasterProtein" "Q99707" "Methionine synthase OS=Homo sapiens OX=9606 GN=MTR PE=1 SV=2" "0.000" "False" "8.269" "2" "2" "2" "2" "1265" "140.4" "5.58" "6.21" "2" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf00809, Pf02310, Pf02574, Pf02607, Pf02965" "4548" "ENSG00000116984" "MTR" "A1L4N8; A9Z1W4; B7ZLW7; B9EGF7; hsa:4548; Q99707; Q99713; Q99723" "Selenium micronutrient network; Vitamin B12 metabolism; Folate-alcohol and cancer pathway hypotheses; Folate metabolism; Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; Vitamin B12 disorders; Male infertility; Spina bifida" "RHOH GTPase cycle; Methylation; Cobalamin (Cbl) metabolism; Sulfur amino acid metabolism; Defective MTRR causes HMAE; Defective MTR causes HMAG" "19" "0" "0.985" "0.921" "1.160" "1.129" "1.031" "1.218" "0.955" "1.204" "2.885" "160.4" "158.0" "147.8" "186.1" "181.0" "165.5" "195.4" "153.2" "193.1" "462.8" "" "" "" "" "" "" "" "" "" "" "84.9" "87.6" "84.6" "85.7" "98.0" "92.0" "115.0" "83.6" "108.3" "462.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7918100123629271451" "False" "High" "IsMasterProtein" "Q9NWV4" "CXXC motif containing zinc binding protein OS=Homo sapiens OX=9606 GN=CZIB PE=1 SV=1" "0.000" "False" "8.258" "15" "2" "2" "2" "160" "18.0" "5.01" "6.10" "2" "" "" "other molecular function" "Pf05907" "54987" "ENSG00000162384" "CZIB" "hsa:54987; Q9NWV4" "" "" "0" "0" "1.093" "1.040" "1.142" "0.996" "1.053" "1.096" "1.085" "0.990" "0.777" "357.4" "390.5" "371.8" "408.3" "355.9" "376.2" "391.8" "387.6" "353.7" "277.8" "" "" "" "" "" "" "" "" "" "" "189.2" "216.5" "212.9" "188.0" "192.6" "209.3" "230.6" "211.6" "198.4" "277.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2350486907516670884" "False" "High" "IsMasterProtein" "Q7Z5K2" "Wings apart-like protein homolog OS=Homo sapiens OX=9606 GN=WAPL PE=1 SV=1" "0.000" "False" "8.241" "2" "2" "3" "2" "1190" "132.9" "5.44" "6.92" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07814" "23063" "ENSG00000062650" "WAPL" "A7E2B5; hsa:23063; Q5VSK5; Q7Z5K2; Q8IX10; Q92549" "Cohesin complex - Cornelia de Lange syndrome; 10q22q23 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "6" "0" "1.029" "0.921" "1.253" "0.953" "0.873" "1.215" "0.969" "0.877" "0.738" "123.0" "126.6" "113.3" "154.1" "117.2" "107.4" "149.5" "119.1" "107.8" "90.8" "" "" "" "" "" "" "" "" "" "" "65.1" "70.2" "64.9" "71.0" "63.4" "59.7" "88.0" "65.0" "60.5" "90.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-767357545140157834" "False" "High" "IsMasterProtein" "P51784" "Ubiquitin carboxyl-terminal hydrolase 11 OS=Homo sapiens OX=9606 GN=USP11 PE=1 SV=3" "0.000" "False" "8.239" "3" "3" "3" "3" "963" "109.7" "5.45" "4.87" "3" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf06337, Pf14533, Pf14836" "" "ENSG00000102226" "USP11" "B2RTX1; P51784; Q8IUG6; Q9BWE1" "" "Ub-specific processing proteases; Association of TriC/CCT with target proteins during biosynthesis" "2" "0" "2.708" "1.647" "2.684" "4.285" "1.600" "3.584" "1.055" "2.195" "6.283" "15.0" "40.5" "24.6" "40.2" "64.1" "23.9" "53.6" "15.8" "32.8" "94.0" "" "" "" "" "" "" "" "" "" "" "7.9" "22.5" "14.1" "18.5" "34.7" "13.3" "31.5" "8.6" "18.4" "94.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2974219725755957834" "False" "High" "IsMasterProtein" "Q5HYJ3" "Protein FAM76B OS=Homo sapiens OX=9606 GN=FAM76B PE=1 SV=3" "0.000" "False" "8.227" "10" "4" "4" "4" "339" "38.7" "9.25" "10.20" "4" "" "nucleus" "" "Pf16046" "143684" "ENSG00000077458" "FAM76B" "B2R9C2; hsa:143684; Q5HYJ3; Q6PIU3; Q8TC53" "" "" "0" "0" "1.183" "1.230" "1.196" "1.059" "1.059" "1.208" "1.228" "1.278" "0.875" "138.7" "164.1" "170.5" "165.9" "146.9" "146.8" "167.5" "170.3" "177.3" "121.4" "" "" "" "" "" "" "" "" "" "" "73.4" "91.0" "97.7" "76.4" "79.5" "81.7" "98.6" "92.9" "99.4" "121.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6470269132294442760" "False" "High" "IsMasterProtein" "Q8WUM0" "Nuclear pore complex protein Nup133 OS=Homo sapiens OX=9606 GN=NUP133 PE=1 SV=2" "0.000" "False" "8.211" "2" "3" "3" "3" "1156" "128.9" "5.10" "7.96" "3" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03177" "55746" "ENSG00000069248" "NUP133" "B2RAZ8; hsa:55746; Q5T8N0; Q8WUM0; Q9H9W2; Q9NV71; Q9NVC4" "Ciliary landscape" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; SUMOylation of DNA replication proteins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Regulation of HSF1-mediated heat shock response; snRNP Assembly; HCMV Early Events; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation" "36" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "275596885495269995" "False" "High" "IsMasterProtein" "Q14166" "Tubulin--tyrosine ligase-like protein 12 OS=Homo sapiens OX=9606 GN=TTLL12 PE=1 SV=2" "0.000" "False" "8.204" "5" "3" "4" "3" "644" "74.4" "5.53" "6.72" "3" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03133" "23170" "ENSG00000100304" "TTLL12" "hsa:23170; Q14166; Q20WK5; Q9UGU3" "" "Carboxyterminal post-translational modifications of tubulin" "1" "0" "1.266" "1.041" "1.128" "1.313" "0.931" "1.185" "0.458" "0.985" "9.492" "54.2" "68.7" "56.5" "61.2" "71.2" "50.5" "64.3" "24.8" "53.4" "514.9" "" "" "" "" "" "" "" "" "" "" "28.7" "38.1" "32.3" "28.2" "38.5" "28.1" "37.8" "13.5" "30.0" "514.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3509057874585176951" "False" "High" "IsMasterProtein" "Q9GZS1" "DNA-directed RNA polymerase I subunit RPA49 OS=Homo sapiens OX=9606 GN=POLR1E PE=1 SV=3" "0.000" "False" "8.204" "6" "3" "4" "3" "419" "47.2" "8.94" "11.43" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06870" "64425" "ENSG00000137054" "POLR1E" "hsa:64425; Q5VZT3; Q8NBA9; Q96L20; Q9GZS1" "Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome; Rubinstein-Taybi syndrome 1" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination" "9" "0" "1.024" "1.138" "1.326" "1.180" "1.366" "1.545" "0.804" "1.213" "6.247" "40.5" "41.5" "46.1" "53.7" "47.8" "55.4" "62.6" "32.6" "49.2" "253.2" "" "" "" "" "" "" "" "" "" "" "21.5" "23.0" "26.4" "24.7" "25.9" "30.8" "36.9" "17.8" "27.6" "253.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-692133851352470930" "False" "High" "IsMasterProtein" "Q14376" "UDP-glucose 4-epimerase OS=Homo sapiens OX=9606 GN=GALE PE=1 SV=2" "0.000" "False" "8.201" "6" "2" "4" "2" "348" "38.3" "6.73" "10.00" "2" "other metabolic processes" "cytosol" "other molecular function" "Pf16363" "2582" "ENSG00000117308" "GALE" "A0A024RAH5; B3KQ39; hsa:2582; Q14376; Q38G75; Q86W41; Q9BVE3; Q9UJB4" "Disorders of galactose metabolism ; UDP-derived sugars synthesis in fibroblasts" "Galactose catabolism; Defective GALE causes EDG" "4" "0" "0.962" "0.974" "0.924" "1.038" "1.043" "0.908" "0.932" "0.915" "0.655" "625.8" "601.8" "609.5" "578.3" "649.6" "652.9" "568.1" "583.0" "572.5" "410.0" "" "" "" "" "" "" "" "" "" "" "331.4" "333.6" "349.1" "266.3" "351.4" "363.2" "334.4" "318.2" "321.1" "410.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8531201272546720497" "False" "High" "IsMasterProtein" "P14854" "Cytochrome c oxidase subunit 6B1 OS=Homo sapiens OX=9606 GN=COX6B1 PE=1 SV=2" "0.000" "False" "8.199" "27" "3" "4" "3" "86" "10.2" "7.05" "11.03" "3" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf02297" "1340" "ENSG00000126267" "COX6B1" "B2R5C9; hsa:1340; P14854; Q6IBL4" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "Cytoprotection by HMOX1; Respiratory electron transport; TP53 Regulates Metabolic Genes" "7" "0" "1.015" "0.970" "1.040" "0.979" "0.943" "0.977" "1.031" "0.897" "0.550" "507.0" "514.5" "491.9" "527.4" "496.4" "478.3" "495.4" "522.8" "454.9" "278.9" "" "" "" "" "" "" "" "" "" "" "268.5" "285.3" "281.7" "242.9" "268.6" "266.1" "291.5" "285.3" "255.2" "278.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8760607610450426056" "False" "High" "IsMasterProtein" "P35251" "Replication factor C subunit 1 OS=Homo sapiens OX=9606 GN=RFC1 PE=1 SV=4" "0.000" "False" "8.187" "3" "4" "4" "4" "1148" "128.2" "9.36" "8.86" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00004, Pf00533, Pf08519" "5981" "ENSG00000035928" "RFC1" "A8K6E7; hsa:5981; P35251; Q5XKF5; Q6PKU0; Q86V41; Q86V46" "miRNA regulation of DNA damage response; DNA replication; Male infertility; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair; DNA damage response" "PCNA-Dependent Long Patch Base Excision Repair; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "22" "0" "0.983" "1.004" "1.229" "1.097" "1.017" "1.214" "0.865" "1.401" "6.186" "199.3" "195.9" "200.1" "245.0" "218.6" "202.7" "242.0" "172.3" "279.1" "1232.7" "" "" "" "" "" "" "" "" "" "" "105.5" "108.6" "114.6" "112.8" "118.3" "112.7" "142.4" "94.1" "156.6" "1232.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8467787264096672406" "False" "High" "IsMasterProtein" "O00506" "Serine/threonine-protein kinase 25 OS=Homo sapiens OX=9606 GN=STK25 PE=1 SV=1" "0.000" "False" "8.177" "5" "2" "3" "1" "426" "48.1" "6.74" "5.37" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf20929" "10494" "ENSG00000115694" "STK25" "A8K6Z3; A8K7D2; B7Z9K1; hsa:10494; O00506; Q15522; Q5BJF1" "2q37 copy number variation syndrome" "" "1" "0" "1.161" "1.035" "1.304" "0.930" "1.032" "0.965" "0.996" "0.944" "0.771" "83.7" "97.2" "86.6" "109.1" "77.8" "86.4" "80.8" "83.3" "79.0" "64.5" "" "" "" "" "" "" "" "" "" "" "44.3" "53.9" "49.6" "50.3" "42.1" "48.0" "47.5" "45.5" "44.3" "64.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8157399823022384529" "False" "High" "IsMasterProtein" "Q99567" "Nuclear pore complex protein Nup88 OS=Homo sapiens OX=9606 GN=NUP88 PE=1 SV=2" "0.000" "False" "8.162" "4" "3" "3" "3" "741" "83.5" "5.69" "6.67" "3" "other metabolic processes;transport" "cytosol;nucleus" "other molecular function" "Pf10168" "4927" "ENSG00000108559" "NUP88" "D3DTM2; hsa:4927; Q99567; Q9BWE5" "Ciliary landscape" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Viral Messenger RNA Synthesis; HCMV Early Events; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)" "29" "0" "0.884" "0.897" "0.980" "0.946" "0.891" "0.992" "0.634" "0.830" "2.784" "129.1" "114.2" "115.9" "126.6" "122.2" "115.1" "128.1" "81.9" "107.2" "359.6" "" "" "" "" "" "" "" "" "" "" "68.4" "63.3" "66.3" "58.3" "66.1" "64.0" "75.4" "44.7" "60.1" "359.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7107318601171383488" "False" "High" "IsMasterProtein" "Q9Y3C8" "Ubiquitin-fold modifier-conjugating enzyme 1 OS=Homo sapiens OX=9606 GN=UFC1 PE=1 SV=3" "0.000" "False" "8.158" "15" "3" "5" "3" "167" "19.4" "7.40" "11.72" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes" "" "other molecular function" "Pf08694" "51506" "ENSG00000143222" "UFC1" "A8K9R1; D3DVF9; hsa:51506; Q549X0; Q5VTX1; Q9BS96; Q9P009; Q9Y3C8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5224017387005900556" "False" "High" "IsMasterProtein" "Q9Y4A5" "Transformation/transcription domain-associated protein OS=Homo sapiens OX=9606 GN=TRRAP PE=1 SV=3" "0.000" "False" "8.153" "1" "3" "3" "3" "3859" "437.3" "8.19" "4.94" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00454, Pf02259, Pf20175, Pf20206" "8295" "ENSG00000196367" "TRRAP" "A4D265; hsa:8295; O75218; Q9Y4A5; Q9Y631; Q9Y6H4" "Rett syndrome" "Ub-specific processing proteases; Formation of the beta-catenin:TCF transactivating complex; HATs acetylate histones" "4" "0" "1.276" "1.057" "0.905" "0.854" "1.131" "1.088" "1.341" "1.225" "2.261" "45.0" "57.4" "47.5" "40.7" "38.4" "50.9" "48.9" "60.3" "55.1" "101.6" "" "" "" "" "" "" "" "" "" "" "23.8" "31.8" "27.2" "18.7" "20.8" "28.3" "28.8" "32.9" "30.9" "101.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2492705213444431370" "False" "High" "IsMasterProtein" "Q8TE04" "Pantothenate kinase 1 OS=Homo sapiens OX=9606 GN=PANK1 PE=1 SV=2" "0.000" "False" "8.143" "3" "2" "2" "2" "598" "64.3" "7.56" "5.77" "2" "other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf03630" "53354" "ENSG00000152782" "PANK1" "A6NIP0; hsa:53354; Q7RTX6; Q7Z495; Q8TBQ8; Q8TE04" "" "Coenzyme A biosynthesis" "1" "0" "0.931" "0.900" "0.845" "0.990" "0.991" "0.871" "0.856" "0.886" "0.617" "311.9" "290.2" "280.8" "263.7" "308.8" "309.2" "271.6" "267.1" "276.3" "192.4" "" "" "" "" "" "" "" "" "" "" "165.1" "160.9" "160.8" "121.4" "167.1" "172.0" "159.8" "145.8" "155.0" "192.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7726317818688943966" "False" "High" "IsMasterProtein" "Q9NQC3" "Reticulon-4 OS=Homo sapiens OX=9606 GN=RTN4 PE=1 SV=2" "0.000" "False" "8.131" "1" "1" "2" "1" "1192" "129.9" "4.50" "6.83" "1" "cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02453" "57142" "ENSG00000115310" "RTN4" "O94962; Q7L7Q5; Q7L7Q6; Q7L7Q8; Q8IUA4; Q96B16; Q9BXG5; Q9H212; Q9H3I3; Q9NQC3; Q9UQ42; Q9Y293; Q9Y2Y7; Q9Y5U6" "Alzheimer's disease and miRNA effects; Spinal cord injury; 22q11.2 copy number variation syndrome; Alzheimer's disease; Neurogenesis regulation in the olfactory epithelium; 13q12.12 copy number variation" "Axonal growth inhibition (RHOA activation)" "7" "0" "1.125" "1.126" "1.362" "1.174" "1.249" "1.007" "1.135" "1.107" "0.871" "109.6" "123.2" "123.3" "149.3" "128.6" "136.9" "110.4" "124.3" "121.3" "95.4" "" "" "" "" "" "" "" "" "" "" "58.0" "68.3" "70.6" "68.8" "69.6" "76.1" "65.0" "67.9" "68.0" "95.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6640745081908687038" "False" "High" "IsMasterProtein" "O75521" "Enoyl-CoA delta isomerase 2 OS=Homo sapiens OX=9606 GN=ECI2 PE=1 SV=4" "0.000" "False" "8.124" "8" "3" "5" "3" "394" "43.6" "9.00" "12.67" "3" "other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00378, Pf00887" "10455" "ENSG00000198721" "ECI2" "hsa:10455; O75521; Q5JYK5; Q5JYK7; Q7L124; Q8N0X0; Q9BUE9; Q9H0T9; Q9NQH1; Q9NYH7; Q9UN55" "" "" "0" "0" "0.826" "0.920" "0.834" "0.872" "0.950" "0.912" "0.917" "0.926" "0.677" "523.5" "432.5" "481.7" "436.7" "456.4" "497.4" "477.4" "480.1" "484.7" "354.3" "" "" "" "" "" "" "" "" "" "" "277.2" "239.8" "275.9" "201.1" "246.9" "276.7" "281.0" "262.1" "271.9" "354.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3935713179938084537" "False" "High" "IsMasterProtein" "Q96HP4" "Oxidoreductase NAD-binding domain-containing protein 1 OS=Homo sapiens OX=9606 GN=OXNAD1 PE=1 SV=1" "0.000" "False" "8.086" "10" "3" "3" "3" "312" "34.8" "8.37" "7.36" "3" "" "" "other molecular function" "Pf00175" "92106" "ENSG00000154814" "OXNAD1" "hsa:92106; Q2HYC7; Q59FA4; Q96HP4" "" "" "0" "0" "0.930" "0.868" "0.904" "1.055" "0.983" "0.851" "0.938" "0.904" "0.583" "285.9" "265.8" "248.2" "258.5" "301.6" "281.0" "243.2" "268.0" "258.6" "166.7" "" "" "" "" "" "" "" "" "" "" "151.4" "147.4" "142.2" "119.0" "163.2" "156.3" "143.2" "146.3" "145.0" "166.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4115257495252240726" "False" "High" "IsMasterProtein" "P82909" "Alpha-ketoglutarate dehydrogenase component 4 OS=Homo sapiens OX=9606 GN=KGD4 PE=1 SV=2" "0.000" "False" "8.084" "12" "1" "5" "1" "103" "11.5" "9.99" "13.26" "1" "other metabolic processes" "other membranes;mitochondrion" "" "" "92259" "ENSG00000134056; ENSG00000278461" "KGD4" "hsa:92259; P82909; Q9H2H4" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.948" "0.979" "0.891" "0.903" "0.876" "0.873" "0.901" "0.846" "0.533" "239.2" "226.8" "234.3" "213.1" "216.1" "209.4" "208.9" "215.4" "202.4" "127.6" "" "" "" "" "" "" "" "" "" "" "126.7" "125.7" "134.2" "98.1" "116.9" "116.5" "122.9" "117.6" "113.5" "127.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5278147799990617038" "False" "High" "IsMasterProtein" "P78318" "Immunoglobulin-binding protein 1 OS=Homo sapiens OX=9606 GN=IGBP1 PE=1 SV=1" "0.000" "False" "8.082" "6" "2" "2" "2" "339" "39.2" "5.38" "6.43" "2" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf04177" "3476" "ENSG00000089289" "IGBP1" "P78318; Q8TAB2" "16p11.2 proximal deletion syndrome" "" "1" "0" "0.905" "0.904" "1.085" "0.854" "1.054" "0.974" "0.962" "0.994" "1.206" "228.5" "206.7" "206.6" "247.9" "195.2" "240.8" "222.6" "219.7" "227.0" "275.5" "" "" "" "" "" "" "" "" "" "" "121.0" "114.6" "118.3" "114.1" "105.6" "133.9" "131.0" "119.9" "127.4" "275.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4076214252454433299" "False" "High" "IsMasterProtein" "Q969G3" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 OS=Homo sapiens OX=9606 GN=SMARCE1 PE=1 SV=2" "0.000" "False" "8.075" "4" "2" "3" "2" "411" "46.6" "4.88" "7.96" "2" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505" "6605" "ENSG00000073584" "SMARCE1" "B3KMC1; B4DFR4; C0IMW4; C0IMW5; C0IMW7; H7C3F6; hsa:6605; O43539; Q969G3" "Androgen receptor signaling pathway; Pathways affected in adenoid cystic carcinoma; Tumor suppressor activity of SMARCB1; Thermogenesis" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "6" "0" "1.237" "1.101" "1.158" "1.019" "1.098" "1.198" "0.735" "1.271" "6.465" "175.3" "216.8" "193.1" "203.0" "178.5" "192.4" "209.9" "128.8" "222.8" "1133.2" "" "" "" "" "" "" "" "" "" "" "92.8" "120.2" "110.6" "93.5" "96.6" "107.0" "123.6" "70.3" "125.0" "1133.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4097484419734302186" "False" "High" "IsMasterProtein" "Q9UBL3" "Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Homo sapiens OX=9606 GN=ASH2L PE=1 SV=1" "0.000" "False" "8.072" "4" "3" "3" "3" "628" "68.7" "5.69" "7.98" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00622, Pf21198, Pf21257" "9070" "ENSG00000129691" "ASH2L" "A8K7C3; D3DSW9; hsa:9070; O60659; O60660; Q96B62; Q9UBL3" "Kleefstra syndrome" "Deactivation of the beta-catenin transactivating complex; Formation of the beta-catenin:TCF transactivating complex; Formation of WDR5-containing histone-modifying complexes; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "7" "0" "1.016" "0.980" "0.969" "0.989" "1.066" "0.933" "0.808" "0.984" "1.979" "325.0" "330.2" "318.7" "315.1" "321.4" "346.4" "303.2" "262.8" "319.9" "643.2" "" "" "" "" "" "" "" "" "" "" "172.1" "183.1" "182.5" "145.1" "173.9" "192.7" "178.4" "143.4" "179.5" "643.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5991678768207076864" "False" "High" "IsMasterProtein" "Q9UNF1" "Melanoma-associated antigen D2 OS=Homo sapiens OX=9606 GN=MAGED2 PE=1 SV=2" "0.000" "False" "8.069" "5" "4" "4" "4" "606" "64.9" "9.32" "9.09" "4" "transport;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf01454" "10916" "ENSG00000102316" "MAGED2" "A6NMX0; hsa:10916; O76058; Q5BJF3; Q8NAL6; Q9H218; Q9P0U9; Q9UM52; Q9UNF1" "" "Platelet degranulation" "1" "0" "1.018" "1.005" "1.134" "1.136" "1.074" "1.065" "0.894" "1.028" "2.221" "576.8" "587.3" "579.6" "654.1" "655.5" "619.6" "614.0" "515.7" "592.8" "1280.9" "" "" "" "" "" "" "" "" "" "" "305.4" "325.6" "331.9" "301.2" "354.6" "344.7" "361.3" "281.5" "332.5" "1280.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7463306019950863991" "False" "High" "IsMasterProtein" "O60784" "Target of Myb1 membrane trafficking protein OS=Homo sapiens OX=9606 GN=TOM1 PE=1 SV=2" "0.000" "False" "8.057" "6" "3" "3" "3" "492" "53.8" "4.70" "4.72" "3" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00790, Pf03127" "10043" "ENSG00000100284" "TOM1" "B4DEL9; B4DNA1; hsa:10043; O60784; Q5TIJ6; Q86X74" "" "Neutrophil degranulation" "1" "0" "1.071" "1.010" "1.174" "1.351" "1.156" "1.352" "1.287" "1.381" "1.336" "89.3" "95.6" "90.2" "104.9" "120.6" "103.2" "120.7" "114.9" "123.3" "119.3" "" "" "" "" "" "" "" "" "" "" "47.3" "53.0" "51.6" "48.3" "65.3" "57.4" "71.0" "62.7" "69.2" "119.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4959898328745925415" "False" "High" "IsMasterProtein" "Q6IN84" "rRNA methyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=MRM1 PE=1 SV=1" "0.000" "False" "8.053" "9" "3" "3" "3" "353" "38.6" "7.94" "7.95" "3" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00588, Pf08032" "79922" "ENSG00000274853; ENSG00000278619" "MRM1" "A8K8E2; hsa:79922; Q6IN84; Q96GK2; Q9H664" "17q12 copy number variation syndrome" "rRNA modification in the mitochondrion" "2" "0" "1.231" "1.148" "1.259" "1.544" "1.066" "1.339" "0.959" "1.877" "0.831" "119.2" "146.7" "136.8" "150.1" "184.1" "127.0" "159.6" "114.3" "223.7" "99.1" "" "" "" "" "" "" "" "" "" "" "63.1" "81.3" "78.3" "69.1" "99.6" "70.7" "93.9" "62.4" "125.5" "99.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6049442156646566229" "False" "High" "IsMasterProtein" "Q6UXN9" "WD repeat-containing protein 82 OS=Homo sapiens OX=9606 GN=WDR82 PE=1 SV=1" "0.000" "False" "8.051" "12" "5" "7" "5" "313" "35.1" "7.69" "17.44" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400" "80335" "ENSG00000164091" "WDR82" "A8K5R5; hsa:80335; Q6UXN9; Q8TEB2" "" "Formation of WDR5-containing histone-modifying complexes" "1" "0" "0.883" "1.051" "0.991" "0.976" "1.014" "1.178" "1.131" "1.293" "0.775" "168.4" "148.7" "176.9" "166.8" "164.4" "170.7" "198.3" "190.4" "217.7" "130.4" "" "" "" "" "" "" "" "" "" "" "89.2" "82.5" "101.3" "76.8" "88.9" "94.9" "116.7" "103.9" "122.1" "130.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "353320057128082956" "False" "High" "IsMasterProtein" "Q13242" "Serine/arginine-rich splicing factor 9 OS=Homo sapiens OX=9606 GN=SRSF9 PE=1 SV=1" "0.000" "False" "8.043" "14" "3" "4" "3" "221" "25.5" "8.65" "7.14" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00076" "8683" "ENSG00000111786" "SRSF9" "hsa:8683; Q13242; Q52LD1" "mRNA processing" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "6" "0" "1.024" "1.051" "1.107" "1.042" "1.013" "1.023" "1.004" "0.948" "0.867" "638.2" "653.8" "670.9" "706.6" "664.9" "646.7" "653.1" "640.8" "604.8" "553.1" "" "" "" "" "" "" "" "" "" "" "337.9" "362.5" "384.2" "325.4" "359.7" "359.7" "384.4" "349.8" "339.3" "553.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1962544655148758053" "False" "High" "IsMasterProtein" "P35240" "Merlin OS=Homo sapiens OX=9606 GN=NF2 PE=1 SV=1" "0.000" "False" "8.029" "4" "3" "3" "3" "595" "69.6" "6.47" "7.90" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "4771" "ENSG00000186575" "NF2" "hsa:4771; O95683; P35240; Q8WUJ2; Q969N0; Q969Q3; Q96T30; Q96T31; Q96T32; Q96T33; Q9BTW3; Q9UNG9; Q9UNH3; Q9UNH4" "Ectoderm differentiation; Ectoderm differentiation; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; 3q29 copy number variation syndrome; Pleural mesothelioma" "Regulation of actin dynamics for phagocytic cup formation; RHO GTPases activate PAKs" "10" "0" "1.009" "1.016" "0.966" "1.108" "1.028" "0.971" "0.861" "1.096" "1.693" "200.3" "202.2" "203.6" "193.4" "221.9" "205.9" "194.4" "172.5" "219.5" "339.0" "" "" "" "" "" "" "" "" "" "" "106.0" "112.1" "116.6" "89.1" "120.1" "114.5" "114.4" "94.1" "123.1" "339.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2548334964560567831" "False" "High" "IsMasterProtein" "Q9GZT8" "NIF3-like protein 1 OS=Homo sapiens OX=9606 GN=NIF3L1 PE=1 SV=2" "0.000" "False" "8.019" "6" "2" "4" "2" "377" "41.9" "6.65" "8.26" "2" "developmental processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf01784" "60491" "ENSG00000196290" "NIF3L1" "hsa:60491; Q53TX4; Q6X735; Q9GZT8; Q9H2D2; Q9HC18" "" "" "0" "0" "1.083" "0.924" "1.215" "1.060" "0.910" "1.031" "1.054" "1.243" "0.679" "192.9" "208.9" "178.2" "234.3" "204.6" "175.5" "199.0" "203.4" "239.9" "130.9" "" "" "" "" "" "" "" "" "" "" "102.2" "115.8" "102.1" "107.9" "110.7" "97.6" "117.1" "111.0" "134.6" "130.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-398928808883879512" "False" "High" "IsMasterProtein" "P07311" "Acylphosphatase-1 OS=Homo sapiens OX=9606 GN=ACYP1 PE=1 SV=2" "0.000" "False" "8.014" "23" "3" "5" "3" "99" "11.3" "9.31" "12.01" "3" "other metabolic processes" "" "other molecular function" "Pf00708" "97" "ENSG00000119640" "ACYP1" "A6NDV8; B2R590; hsa:97; P07311" "" "" "0" "0" "0.963" "1.026" "0.973" "0.883" "0.851" "0.820" "1.000" "0.921" "0.535" "718.4" "692.1" "736.8" "699.0" "634.3" "611.7" "589.2" "718.3" "661.6" "384.2" "" "" "" "" "" "" "" "" "" "" "380.4" "383.7" "421.9" "321.9" "343.2" "340.2" "346.8" "392.1" "371.2" "384.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4024286234021820395" "False" "High" "IsMasterProtein" "P78406" "mRNA export factor RAE1 OS=Homo sapiens OX=9606 GN=RAE1 PE=1 SV=1" "0.000" "False" "8.011" "5" "2" "2" "2" "368" "40.9" "7.83" "5.51" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00400" "8480" "ENSG00000101146" "RAE1" "A8K882; hsa:8480; O15306; P78406; Q3SYL7; Q5TCH8; Q6V708; Q9H100; Q9NQM6" "IL-18 signaling pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; HCMV Early Events; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Regulation of HSF1-mediated heat shock response; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus" "30" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-379596745727063060" "False" "High" "IsMasterProtein" "Q96CW6" "Probable RNA polymerase II nuclear localization protein SLC7A6OS OS=Homo sapiens OX=9606 GN=SLC7A6OS PE=1 SV=2" "0.000" "False" "8.000" "7" "2" "3" "2" "309" "35.0" "4.60" "9.43" "2" "transport;other biological processes" "nucleus;other cell component" "" "Pf08574" "84138" "ENSG00000103061" "SLC7A6OS" "hsa:84138; Q8TCZ3; Q96CW6; Q9H8R8" "" "" "0" "0" "1.123" "1.083" "1.218" "1.150" "1.153" "1.155" "1.096" "1.129" "0.983" "252.1" "283.1" "273.0" "307.1" "289.8" "290.6" "291.2" "276.3" "284.6" "247.9" "" "" "" "" "" "" "" "" "" "" "133.5" "156.9" "156.3" "141.4" "156.8" "161.7" "171.4" "150.8" "159.7" "247.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9042131036706186365" "False" "High" "IsMasterProtein" "Q13485" "Mothers against decapentaplegic homolog 4 OS=Homo sapiens OX=9606 GN=SMAD4 PE=1 SV=1" "0.000" "False" "7.996" "3" "2" "2" "2" "552" "60.4" "6.99" "7.10" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf03165, Pf03166" "4089" "ENSG00000141646" "SMAD4" "A8K405; hsa:4089; Q13485" "Androgen receptor signaling pathway; Bone morphogenic protein signaling and regulation; Heart development; Cell cycle; Endoderm differentiation; Mesodermal commitment pathway; Ectoderm differentiation; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; Hepatitis C and hepatocellular carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Canonical and non-canonical TGF-B signaling; BMP signaling in eyelid development; Embryonic stem cell pluripotency pathways; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Vitamin D in inflammatory diseases; Envelope proteins and their potential roles in EDMD physiopathology; Hepatitis B infection; Head and neck squamous cell carcinoma; Osteoblast differentiation and related diseases; TGF-beta receptor signaling in skeletal dysplasias; Regucalcin in proximal tubule epithelial kidney cells; Angiotensin II receptor type 1 pathway; Neuroinflammation and glutamatergic signaling; Progeria-associated lipodystrophy; Clock-controlled autophagy in bone metabolism; Rubinstein-Taybi syndrome 1; TGF-beta receptor signaling; DNA damage response (only ATM dependent)" "Ub-specific processing proteases; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Signaling by BMP; Signaling by NODAL; FOXO-mediated transcription of cell cycle genes; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Cardiogenesis; Germ layer formation at gastrulation; Formation of definitive endoderm; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Transcriptional regulation of pluripotent stem cells; RUNX3 regulates BCL2L11 (BIM) transcription; RUNX2 regulates bone development; Signaling by Activin; TGF-beta receptor signaling activates SMADs; RUNX3 regulates CDKN1A transcription; SMAD4 MH2 Domain Mutants in Cancer; SMAD2/3 MH2 Domain Mutants in Cancer" "53" "0" "0.888" "0.923" "0.913" "0.985" "0.920" "0.932" "0.888" "0.936" "0.982" "558.9" "496.5" "516.0" "510.3" "550.6" "514.1" "521.0" "496.5" "523.3" "548.7" "" "" "" "" "" "" "" "" "" "" "296.0" "275.3" "295.5" "235.0" "297.9" "286.0" "306.6" "271.0" "293.5" "548.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4342326397945372791" "False" "High" "IsMasterProtein" "O75150" "E3 ubiquitin-protein ligase BRE1B OS=Homo sapiens OX=9606 GN=RNF40 PE=1 SV=5" "0.000" "False" "7.992" "2" "2" "3" "2" "1001" "113.6" "6.29" "5.91" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097" "9810" "ENSG00000103549" "RNF40" "A0A024QZG0; hsa:9810; O75150; Q6AHZ6; Q6N005; Q7L3T6; Q8N615; Q96T18; Q9BSV9; Q9HC82" "ATM signaling in development and disease" "E3 ubiquitin ligases ubiquitinate target proteins" "2" "0" "0.981" "1.166" "1.424" "1.187" "1.152" "1.386" "1.045" "1.239" "4.058" "48.4" "47.4" "56.4" "68.9" "57.4" "55.7" "67.0" "50.6" "59.9" "196.2" "" "" "" "" "" "" "" "" "" "" "25.6" "26.3" "32.3" "31.7" "31.1" "31.0" "39.5" "27.6" "33.6" "196.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6182186368676627238" "False" "High" "IsMasterProtein" "Q13405" "Large ribosomal subunit protein mL49 OS=Homo sapiens OX=9606 GN=MRPL49 PE=1 SV=1" "0.000" "False" "7.988" "13" "2" "2" "2" "166" "19.2" "9.45" "6.10" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf05046" "740" "ENSG00000149792" "MRPL49" "B2R4G6; hsa:740; Q13405" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.004" "0.965" "0.975" "1.060" "1.140" "1.042" "0.998" "1.129" "0.986" "186.8" "187.5" "180.3" "182.1" "198.0" "213.0" "194.7" "186.5" "211.0" "184.2" "" "" "" "" "" "" "" "" "" "" "98.9" "104.0" "103.2" "83.9" "107.1" "118.5" "114.6" "101.8" "118.4" "184.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6667774858643488951" "False" "High" "IsMasterProtein" "P11308" "Transcriptional regulator ERG OS=Homo sapiens OX=9606 GN=ERG PE=1 SV=3" "0.000" "False" "7.972" "6" "2" "2" "2" "479" "53.8" "7.65" "3.78" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf02198" "2078" "ENSG00000157554" "ERG" "B4DTW5; B4E0T4; hsa:2078; P11308; Q16113; Q6XXX4; Q6XXX5; Q8IXK9" "Genes targeted by miRNAs in adipocytes; Androgen receptor network in prostate cancer; VEGFA-VEGFR2 signaling; HDAC6 interactions in the central nervous system" "" "4" "0" "0.807" "1.361" "1.552" "1.297" "1.409" "1.625" "1.601" "1.393" "2.108" "41.7" "33.7" "56.8" "64.8" "54.1" "58.8" "67.8" "66.8" "58.1" "88.0" "" "" "" "" "" "" "" "" "" "" "22.1" "18.7" "32.5" "29.8" "29.3" "32.7" "39.9" "36.5" "32.6" "88.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8357851412820186252" "False" "High" "IsMasterProtein" "O60675" "Transcription factor MafK OS=Homo sapiens OX=9606 GN=MAFK PE=1 SV=1" "0.000" "False" "7.936" "19" "3" "4" "3" "156" "17.5" "10.10" "9.74" "3" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03131" "7975" "ENSG00000198517" "MAFK" "A4D214; hsa:7975; O60675" "Quercetin and Nf-kB / AP-1 induced apoptosis; Ethanol metabolism production of ROS by CYP2E1" "Heme signaling; Factors involved in megakaryocyte development and platelet production; Regulation of HMOX1 expression and activity; Regulation of BACH1 activity; NFE2L2 regulating anti-oxidant/detoxification enzymes; NFE2L2 regulating MDR associated enzymes; Nuclear events mediated by NFE2L2; NFE2L2 regulating inflammation associated genes; NFE2L2 regulating tumorigenic genes; NFE2L2 regulating ER-stress associated genes; Regulation of NFE2L2 gene expression" "13" "0" "1.050" "1.002" "1.131" "1.264" "1.018" "0.944" "0.916" "1.088" "1.630" "85.9" "90.2" "86.1" "97.2" "108.6" "87.4" "81.1" "78.7" "93.5" "140.0" "" "" "" "" "" "" "" "" "" "" "45.5" "50.0" "49.3" "44.8" "58.8" "48.6" "47.7" "43.0" "52.4" "140.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6418921267369266529" "False" "High" "IsMasterProtein" "P31321" "cAMP-dependent protein kinase type I-beta regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR1B PE=1 SV=4" "0.000" "False" "7.929" "6" "3" "5" "1" "381" "43.0" "5.71" "12.78" "3" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf02197" "5575" "ENSG00000188191" "PRKAR1B" "hsa:5575; P31321; Q8N422" "Myometrial relaxation and contraction pathways; G protein signaling pathways; Cannabinoid receptor signaling; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Calcium regulation in cardiac cells; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "FCGR3A-mediated IL10 synthesis; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Hedgehog 'off' state; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase" "21" "0" "0.977" "0.846" "1.075" "0.844" "1.004" "1.137" "0.932" "0.948" "1.226" "79.0" "77.1" "66.8" "84.8" "66.6" "79.3" "89.8" "73.6" "74.9" "96.8" "" "" "" "" "" "" "" "" "" "" "41.8" "42.8" "38.3" "39.1" "36.1" "44.1" "52.8" "40.2" "42.0" "96.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5656635003875974689" "False" "High" "IsMasterProtein" "Q13111" "Chromatin assembly factor 1 subunit A OS=Homo sapiens OX=9606 GN=CHAF1A PE=1 SV=3" "0.000" "False" "7.927" "4" "4" "5" "4" "956" "106.8" "5.94" "8.61" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf11600, Pf12253, Pf15539, Pf15557" "10036" "ENSG00000167670" "CHAF1A" "hsa:10036; Q13111; Q6NXG5; Q7Z7K3; Q9UJY8" "Nanoparticle triggered autophagic cell death" "" "1" "0" "0.901" "0.902" "1.060" "0.956" "0.947" "1.180" "1.104" "1.059" "1.974" "205.7" "185.3" "185.5" "218.0" "196.7" "194.9" "242.7" "227.1" "217.9" "406.1" "" "" "" "" "" "" "" "" "" "" "108.9" "102.7" "106.2" "100.4" "106.4" "108.4" "142.8" "124.0" "122.2" "406.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5750940690254382676" "False" "High" "IsMasterProtein" "P16333" "SH2/SH3 adapter protein NCK1 OS=Homo sapiens OX=9606 GN=NCK1 PE=1 SV=1" "0.000" "False" "7.926" "7" "3" "4" "3" "377" "42.8" "6.47" "10.40" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018" "4690" "ENSG00000158092" "NCK1" "B7Z751; D3DNE3; hsa:4690; P16333" "Pathogenic Escherichia coli infection; B cell receptor signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); RAC1/PAK1/p38/MMP2 pathway; Physico-chemical features and toxicity-associated pathways; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway; Genes controlling nephrogenesis; GDNF signaling; ErbB signaling pathway; T-cell receptor signaling pathway" "Generation of second messenger molecules; RHOU GTPase cycle; Activation of RAC1; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; RHO GTPases Activate WASPs and WAVEs; PKR-mediated signaling; RHOV GTPase cycle; Nephrin family interactions; DCC mediated attractive signaling; Downstream signal transduction; VEGFA-VEGFR2 Pathway" "27" "0" "0.950" "0.545" "1.037" "1.171" "0.733" "0.919" "0.715" "0.952" "2.171" "20.6" "19.5" "11.2" "21.3" "24.1" "15.1" "18.9" "14.7" "19.6" "44.6" "" "" "" "" "" "" "" "" "" "" "10.9" "10.8" "6.4" "9.8" "13.0" "8.4" "11.1" "8.0" "11.0" "44.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9195295084740601325" "False" "High" "IsMasterProtein" "Q00577" "Transcriptional activator protein Pur-alpha OS=Homo sapiens OX=9606 GN=PURA PE=1 SV=2" "0.000" "False" "7.915" "8" "3" "4" "3" "322" "34.9" "6.44" "9.55" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04845" "5813" "ENSG00000185129" "PURA" "hsa:5813; Q00577" "Exercise-induced circadian regulation" "" "1" "0" "0.984" "1.061" "0.941" "1.026" "1.091" "0.955" "1.019" "0.960" "0.644" "389.5" "383.1" "413.4" "366.4" "399.8" "425.0" "372.0" "396.8" "373.8" "250.9" "" "" "" "" "" "" "" "" "" "" "206.2" "212.4" "236.8" "168.7" "216.3" "236.4" "218.9" "216.6" "209.7" "250.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7694143023947037177" "False" "High" "IsMasterProtein" "Q96I15" "Selenocysteine lyase OS=Homo sapiens OX=9606 GN=SCLY PE=1 SV=4" "0.000" "False" "7.908" "5" "3" "4" "3" "445" "48.1" "7.12" "10.86" "3" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00266" "51540" "ENSG00000132330" "SCLY" "B9A068; hsa:51540; J3KN06; Q53SN1; Q53SN8; Q7L670; Q96I15; Q9NVT7; Q9NZR7" "Selenium metabolism and selenoproteins; 2q37 copy number variation syndrome" "Metabolism of ingested SeMet, Sec, MeSec into H2Se" "3" "0" "0.838" "0.881" "0.813" "0.866" "0.908" "0.823" "0.930" "0.919" "0.561" "317.4" "265.9" "279.5" "258.1" "274.8" "288.1" "261.1" "295.2" "291.7" "178.1" "" "" "" "" "" "" "" "" "" "" "168.1" "147.4" "160.1" "118.8" "148.7" "160.3" "153.7" "161.1" "163.6" "178.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1190260410723795831" "False" "High" "IsMasterProtein" "Q14257" "Reticulocalbin-2 OS=Homo sapiens OX=9606 GN=RCN2 PE=1 SV=1" "0.000" "False" "7.880" "8" "3" "3" "3" "317" "36.9" "4.40" "7.27" "3" "" "ER/Golgi;nucleus" "other molecular function" "Pf13202, Pf13499" "5955" "ENSG00000117906" "RCN2" "A8MTG6; F8WCY5; hsa:5955; Q14257; Q53XN8" "" "" "0" "0" "1.246" "1.087" "0.848" "0.868" "1.015" "0.889" "0.820" "1.002" "3.363" "260.5" "324.5" "283.1" "220.9" "226.1" "264.4" "231.5" "213.5" "260.9" "875.9" "" "" "" "" "" "" "" "" "" "" "137.9" "179.9" "162.1" "101.7" "122.3" "147.1" "136.3" "116.5" "146.4" "875.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6403678717829717744" "False" "High" "IsMasterProtein" "Q9H3K6" "BolA-like protein 2 OS=Homo sapiens OX=9606 GN=BOLA2B PE=1 SV=1" "0.000" "False" "7.874" "37" "3" "5" "3" "86" "10.1" "6.52" "13.54" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01722" "552900; 654483" "ENSG00000169627; ENSG00000183336" "BOLA2; BOLA2B" "A1L454; A7YDY3; hsa:552900; hsa:654483; Q9H3K6" "" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "1" "0" "1.098" "1.139" "1.288" "1.223" "1.063" "1.201" "1.159" "0.990" "1.051" "296.1" "325.2" "337.3" "381.4" "362.1" "314.6" "355.6" "343.1" "293.2" "311.2" "" "" "" "" "" "" "" "" "" "" "156.8" "180.3" "193.2" "175.7" "195.9" "175.0" "209.3" "187.3" "164.5" "311.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1273704181858751884" "False" "High" "IsMasterProtein" "Q8N0X4" "Citramalyl-CoA lyase, mitochondrial OS=Homo sapiens OX=9606 GN=CLYBL PE=1 SV=2" "0.000" "False" "7.873" "8" "3" "3" "3" "340" "37.3" "8.73" "5.73" "3" "cell organization and biogenesis;other biological processes" "mitochondrion" "other molecular function" "Pf03328" "171425" "ENSG00000125246" "CLYBL" "hsa:171425; Q5W0F7; Q8N0X4; Q8TDH8" "" "" "0" "0" "1.117" "0.902" "1.046" "0.872" "0.955" "0.872" "1.090" "1.005" "0.599" "184.6" "206.3" "166.5" "193.2" "160.9" "176.3" "161.1" "201.3" "185.6" "110.5" "" "" "" "" "" "" "" "" "" "" "97.8" "114.4" "95.4" "89.0" "87.1" "98.0" "94.8" "109.9" "104.1" "110.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8410241835469765050" "False" "High" "IsMasterProtein" "Q9Y2G2" "Caspase recruitment domain-containing protein 8 OS=Homo sapiens OX=9606 GN=CARD8 PE=1 SV=2" "0.000" "False" "7.867" "5" "3" "4" "3" "537" "60.6" "4.84" "8.99" "3" "cell organization and biogenesis;protein metabolism;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00619, Pf13553" "22900" "ENSG00000105483" "CARD8" "B5KVR6; B5KVR8; B7Z496; B7Z4A2; E5RFV9; E9PEM7; G3XAM9; hsa:22900; Q6PGP8; Q96P82; Q9Y2G2" "Nucleotide-binding oligomerization domain (NOD) pathway" "Regulation of the apoptosome activity" "3" "0" "1.051" "1.011" "1.016" "1.149" "1.070" "1.088" "1.047" "1.066" "1.038" "125.8" "132.2" "127.2" "127.9" "144.6" "134.7" "136.9" "131.7" "134.1" "130.6" "" "" "" "" "" "" "" "" "" "" "66.6" "73.3" "72.8" "58.9" "78.2" "74.9" "80.6" "71.9" "75.2" "130.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8396121455567897427" "False" "High" "IsMasterProtein" "Q9Y4K1" "Beta/gamma crystallin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CRYBG1 PE=1 SV=4" "0.000" "False" "7.865" "1" "2" "2" "2" "2131" "231.6" "5.81" "6.38" "2" "" "" "other molecular function" "Pf00030, Pf00652" "" "ENSG00000112297" "CRYBG1" "A0A0J9YWL0" "" "" "0" "0" "0.932" "0.957" "1.042" "0.992" "1.054" "1.263" "1.108" "1.242" "0.868" "245.3" "228.6" "234.8" "255.7" "243.2" "258.6" "309.8" "271.7" "304.7" "212.9" "" "" "" "" "" "" "" "" "" "" "129.9" "126.7" "134.5" "117.7" "131.6" "143.8" "182.3" "148.3" "170.9" "212.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5248794698895072137" "False" "High" "IsMasterProtein" "Q9NVC6" "Mediator of RNA polymerase II transcription subunit 17 OS=Homo sapiens OX=9606 GN=MED17 PE=1 SV=2" "0.000" "False" "7.861" "4" "3" "3" "3" "651" "72.8" "7.44" "7.08" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10156" "9440" "ENSG00000042429" "MED17" "B3KN07; hsa:9440; Q9HA81; Q9NVC6; Q9UNP7; Q9Y2W0; Q9Y660" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "1.050" "1.022" "1.296" "1.275" "1.093" "1.157" "0.789" "1.009" "3.682" "43.3" "45.5" "44.3" "56.2" "55.3" "47.4" "50.1" "34.2" "43.7" "159.6" "" "" "" "" "" "" "" "" "" "" "23.0" "25.2" "25.4" "25.9" "29.9" "26.4" "29.5" "18.7" "24.5" "159.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2305631654265975414" "False" "High" "IsMasterProtein" "Q96E11" "Ribosome-recycling factor, mitochondrial OS=Homo sapiens OX=9606 GN=MRRF PE=1 SV=1" "0.000" "False" "7.858" "13" "3" "4" "3" "262" "29.3" "9.79" "11.59" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "translation activity" "Pf01765" "92399" "ENSG00000148187" "MRRF" "A8K6D8; A8K6Z4; B7Z4X5; B7Z6P7; hsa:92399; Q5RKT1; Q5T7T0; Q5T7T1; Q5T7T2; Q5T7T3; Q5T7T4; Q5T7T5; Q96E11" "" "Mitochondrial translation termination" "1" "0" "1.044" "1.028" "1.223" "1.038" "0.823" "1.494" "1.020" "0.689" "0.930" "23.7" "24.7" "24.3" "29.0" "24.6" "19.5" "35.4" "24.2" "16.3" "22.0" "" "" "" "" "" "" "" "" "" "" "12.5" "13.7" "13.9" "13.3" "13.3" "10.8" "20.8" "13.2" "9.2" "22.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9218003044822153883" "False" "High" "IsMasterProtein" "O95881" "Thioredoxin domain-containing protein 12 OS=Homo sapiens OX=9606 GN=TXNDC12 PE=1 SV=1" "0.000" "False" "7.850" "18" "3" "5" "3" "172" "19.2" "5.40" "11.98" "3" "other biological processes" "ER/Golgi" "other molecular function" "Pf13899" "51060" "ENSG00000117862" "TXNDC12" "B3KQS0; hsa:51060; O95881; Q5T1T4; Q96H50" "" "" "0" "0" "1.048" "1.174" "1.109" "0.999" "1.061" "0.964" "1.144" "1.035" "1.044" "203.9" "213.8" "239.4" "226.2" "203.7" "216.4" "196.5" "233.2" "211.1" "212.8" "" "" "" "" "" "" "" "" "" "" "108.0" "118.5" "137.1" "104.2" "110.2" "120.4" "115.6" "127.3" "118.4" "212.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4657914547001490376" "False" "High" "IsMasterProtein" "P53778" "Mitogen-activated protein kinase 12 OS=Homo sapiens OX=9606 GN=MAPK12 PE=1 SV=3" "0.000" "False" "7.847" "8" "3" "3" "3" "367" "41.9" "6.39" "8.29" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6300" "ENSG00000188130" "MAPK12" "hsa:6300; P53778; Q14260; Q6IC53; Q99588; Q99672" "Integrin-mediated cell adhesion; Parkinson's disease pathway; S1P receptor signal transduction; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Regulatory circuits of the STAT3 signaling pathway; Hepatitis B infection; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - apoptosis; Host-pathogen interaction of human coronaviruses - MAPK signaling; Toll-like receptor signaling pathway" "VEGFA-VEGFR2 Pathway; Myogenesis; NOD1/2 Signaling Pathway; p38MAPK events; DSCAM interactions; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Negative regulation of MAPK pathway" "30" "0" "0.938" "0.923" "0.962" "0.986" "0.989" "0.885" "0.888" "0.958" "0.683" "664.3" "623.1" "612.9" "639.1" "655.0" "657.1" "587.7" "589.6" "636.5" "453.5" "" "" "" "" "" "" "" "" "" "" "351.8" "345.5" "351.0" "294.3" "354.4" "365.5" "345.9" "321.8" "357.1" "453.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3289616204838975461" "False" "High" "IsMasterProtein" "P62851" "Small ribosomal subunit protein eS25 OS=Homo sapiens OX=9606 GN=RPS25 PE=1 SV=1" "0.000" "False" "7.844" "22" "3" "5" "3" "125" "13.7" "10.11" "13.01" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf03297" "6230" "ENSG00000118181; ENSG00000280831" "RPS25" "B2R4M7; hsa:6230; P25111; P62851" "Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.958" "1.014" "1.028" "1.146" "1.059" "1.135" "1.225" "1.247" "0.714" "770.9" "738.9" "781.6" "792.6" "883.3" "816.6" "874.9" "944.2" "961.7" "550.6" "" "" "" "" "" "" "" "" "" "" "408.2" "409.7" "447.6" "365.0" "477.9" "454.2" "514.9" "515.4" "539.5" "550.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7071014728097244949" "False" "High" "IsMasterProtein" "Q9BW27" "Nuclear pore complex protein Nup85 OS=Homo sapiens OX=9606 GN=NUP85 PE=1 SV=1" "0.000" "False" "7.811" "3" "2" "3" "2" "656" "75.0" "5.55" "9.22" "2" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07575" "79902" "ENSG00000125450" "NUP85" "B4DMQ3; B4DPW1; hsa:79902; Q8NDI4; Q9BW27; Q9H9U1" "" "Separation of Sister Chromatids; Transport of Mature mRNA derived from an Intron-Containing Transcript; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; SARS-CoV-2 activates/modulates innate and adaptive immune responses; SUMOylation of DNA replication proteins; HCMV Early Events; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation" "35" "0" "1.104" "1.056" "1.035" "1.090" "1.187" "1.116" "1.088" "1.121" "1.220" "355.4" "392.3" "375.4" "367.9" "387.3" "422.0" "396.7" "386.7" "398.4" "433.7" "" "" "" "" "" "" "" "" "" "" "188.2" "217.5" "215.0" "169.4" "209.5" "234.7" "233.4" "211.1" "223.5" "433.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8335740267375587213" "False" "High" "IsMasterProtein" "P09132" "Signal recognition particle 19 kDa protein OS=Homo sapiens OX=9606 GN=SRP19 PE=1 SV=3" "0.000" "False" "7.809" "10" "1" "1" "1" "144" "16.1" "9.85" "4.11" "1" "cell organization and biogenesis;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf01922" "6728" "ENSG00000153037" "SRP19" "B2R4E9; D6RCQ5; hsa:6728; P09132; Q05D77; Q96FG6" "" "SRP-dependent cotranslational protein targeting to membrane" "1" "0" "0.958" "1.126" "0.997" "1.176" "1.045" "0.925" "1.003" "0.996" "1.339" "108.4" "103.8" "122.0" "108.1" "127.4" "113.2" "100.3" "108.6" "108.0" "145.1" "" "" "" "" "" "" "" "" "" "" "57.4" "57.6" "69.9" "49.8" "68.9" "63.0" "59.0" "59.3" "60.6" "145.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4676575217961373957" "False" "High" "IsMasterProtein" "P63098" "Calcineurin subunit B type 1 OS=Homo sapiens OX=9606 GN=PPP3R1 PE=1 SV=2" "0.000" "False" "7.805" "6" "1" "3" "1" "170" "19.3" "4.81" "9.08" "1" "transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf13499" "5534" "ENSG00000221823" "PPP3R1" "B2RC10; B5MDU4; hsa:5534; P06705; P15117; P63098; Q08044; Q53SL0" "Energy metabolism; Transcription factors regulate miRNAs related to cardiac hypertrophy; Alzheimer's disease and miRNA effects; Initiation of transcription and translation elongation at the HIV-1 LTR; MAPK signaling pathway; Wnt signaling; Vitamin D in inflammatory diseases; Regucalcin in proximal tubule epithelial kidney cells; Alzheimer's disease" "FCERI mediated Ca+2 mobilization; Ca2+ pathway; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT; DARPP-32 events; Activation of BAD and translocation to mitochondria" "15" "0" "0.992" "0.982" "0.862" "1.055" "0.935" "0.926" "1.159" "1.110" "0.538" "347.6" "344.8" "341.3" "299.7" "366.8" "325.1" "322.0" "402.9" "385.7" "187.0" "" "" "" "" "" "" "" "" "" "" "184.0" "191.1" "195.5" "138.0" "198.5" "180.8" "189.5" "219.9" "216.4" "187.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-510169837627830895" "False" "High" "IsMasterProtein" "P49789" "Bis(5'-adenosyl)-triphosphatase OS=Homo sapiens OX=9606 GN=FHIT PE=1 SV=3" "0.000" "False" "7.804" "16" "2" "3" "2" "147" "16.8" "7.08" "7.02" "2" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01230" "2272" "ENSG00000189283" "FHIT" "A2IAS9; A2IAT0; A2IAT6; A8K1A9; hsa:2272; P49789; Q45QG9; Q6IU12" "Non-small cell lung cancer; Small cell lung cancer" "" "2" "0" "1.046" "1.091" "0.988" "1.118" "1.317" "1.221" "1.182" "1.175" "1.225" "107.4" "112.3" "117.1" "106.1" "120.1" "141.4" "131.1" "126.9" "126.1" "131.6" "" "" "" "" "" "" "" "" "" "" "56.8" "62.2" "67.1" "48.9" "65.0" "78.6" "77.2" "69.3" "70.7" "131.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6811152372553307115" "False" "High" "IsMasterProtein" "Q9Y2X3" "Nucleolar protein 58 OS=Homo sapiens OX=9606 GN=NOP58 PE=1 SV=1" "0.000" "False" "7.804" "5" "2" "2" "2" "529" "59.5" "8.92" "6.07" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01798, Pf08156" "51602" "ENSG00000055044" "NOP58" "hsa:51602; Q53SA4; Q6PK08; Q9P036; Q9UFN3; Q9Y2X3" "" "Major pathway of rRNA processing in the nucleolus and cytosol; SUMOylation of RNA binding proteins; rRNA modification in the nucleus and cytosol" "3" "0" "1.198" "1.182" "1.194" "1.341" "1.071" "1.064" "1.100" "1.189" "1.073" "189.2" "226.7" "223.6" "226.0" "253.9" "202.7" "201.4" "208.2" "225.1" "203.1" "" "" "" "" "" "" "" "" "" "" "100.2" "125.7" "128.1" "104.1" "137.3" "112.7" "118.5" "113.6" "126.3" "203.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1450384486208506068" "False" "High" "IsMasterProtein" "Q96LD4" "E3 ubiquitin-protein ligase TRIM47 OS=Homo sapiens OX=9606 GN=TRIM47 PE=1 SV=2" "0.000" "False" "7.793" "4" "2" "2" "2" "638" "69.5" "6.44" "3.64" "2" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00643, Pf13445" "91107" "ENSG00000132481" "TRIM47" "hsa:91107; Q96AD0; Q96GU5; Q96LD4; Q9BRN7" "" "" "0" "0" "1.276" "0.988" "1.238" "1.278" "1.060" "1.071" "1.006" "1.246" "1.527" "84.9" "108.3" "83.8" "105.1" "108.5" "90.0" "91.0" "85.4" "105.7" "129.6" "" "" "" "" "" "" "" "" "" "" "44.9" "60.1" "48.0" "48.4" "58.7" "50.1" "53.5" "46.6" "59.3" "129.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2103706040263496720" "False" "High" "IsMasterProtein" "Q86YH6" "All trans-polyprenyl-diphosphate synthase PDSS2 OS=Homo sapiens OX=9606 GN=PDSS2 PE=1 SV=2" "0.000" "False" "7.791" "5" "2" "3" "2" "399" "44.1" "8.24" "9.84" "2" "other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00348" "57107" "ENSG00000164494" "PDSS2" "hsa:57107; Q33DR4; Q4G158; Q5VU38; Q5VU39; Q86YH6; Q9NR58" "Nephrotic syndrome" "Ubiquinol biosynthesis" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7585773354798248656" "False" "High" "IsMasterProtein" "O60232" "Protein ZNRD2 OS=Homo sapiens OX=9606 GN=ZNRD2 PE=1 SV=1" "0.000" "False" "7.783" "16" "2" "2" "2" "199" "21.5" "5.24" "3.44" "2" "cell cycle OR cell proliferation;other biological processes" "" "" "Pf06677" "10534" "ENSG00000173465" "ZNRD2" "hsa:10534; O60232" "" "" "0" "0" "1.046" "0.954" "1.000" "0.960" "1.142" "0.994" "1.215" "1.068" "1.037" "108.5" "113.5" "103.5" "108.5" "104.2" "123.8" "107.8" "131.8" "115.9" "112.5" "" "" "" "" "" "" "" "" "" "" "57.4" "62.9" "59.3" "49.9" "56.4" "68.9" "63.4" "72.0" "65.0" "112.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4992003344612717305" "False" "High" "IsMasterProtein" "P30260" "Cell division cycle protein 27 homolog OS=Homo sapiens OX=9606 GN=CDC27 PE=1 SV=2" "0.000" "False" "7.778" "3" "3" "3" "3" "824" "91.8" "7.02" "7.45" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00515, Pf12895" "996" "ENSG00000004897" "CDC27" "G3V1C4; hsa:996; P30260; Q16349; Q96F35" "Cell cycle; 2q21.1 copy number variation syndrome" "Assembly of the pre-replicative complex; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "20" "0" "1.063" "1.039" "1.039" "1.177" "1.071" "0.965" "1.016" "1.101" "1.473" "96.3" "102.4" "100.1" "100.1" "113.4" "103.1" "92.9" "97.9" "106.1" "141.9" "" "" "" "" "" "" "" "" "" "" "51.0" "56.8" "57.3" "46.1" "61.4" "57.4" "54.7" "53.4" "59.5" "141.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3889272514054364250" "False" "High" "IsMasterProtein" "O15541" "E3 ubiquitin-protein ligase RNF113A OS=Homo sapiens OX=9606 GN=RNF113A PE=1 SV=1" "0.000" "False" "7.775" "6" "2" "4" "2" "343" "38.8" "5.69" "7.96" "2" "protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf00642, Pf13920" "7737" "ENSG00000125352" "RNF113A" "B2RBR7; hsa:7737; O15541" "" "mRNA Splicing - Major Pathway" "1" "0" "1.045" "1.115" "1.088" "1.034" "1.039" "0.922" "1.188" "0.913" "0.621" "122.6" "128.1" "136.7" "133.4" "126.8" "127.4" "113.0" "145.6" "112.0" "76.2" "" "" "" "" "" "" "" "" "" "" "64.9" "71.0" "78.3" "61.4" "68.6" "70.9" "66.5" "79.5" "62.8" "76.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4826507384630182713" "False" "High" "IsMasterProtein" "Q96IZ7" "Serine/Arginine-related protein 53 OS=Homo sapiens OX=9606 GN=RSRC1 PE=1 SV=1" "0.000" "False" "7.773" "6" "2" "2" "2" "334" "38.7" "11.08" "5.63" "2" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "" "" "51319" "ENSG00000174891" "RSRC1" "A8K2R9; hsa:51319; Q96IZ7; Q96QK2; Q9NZE5" "" "" "0" "0" "0.833" "0.974" "0.896" "0.994" "0.818" "1.204" "1.047" "1.172" "1.922" "273.4" "227.7" "266.2" "244.9" "271.8" "223.6" "329.2" "286.3" "320.3" "525.3" "" "" "" "" "" "" "" "" "" "" "144.7" "126.3" "152.4" "112.8" "147.0" "124.4" "193.7" "156.3" "179.7" "525.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3645624783218300571" "False" "High" "IsMasterProtein" "Q96CG3" "TRAF-interacting protein with FHA domain-containing protein A OS=Homo sapiens OX=9606 GN=TIFA PE=1 SV=1" "0.000" "False" "7.771" "14" "3" "4" "3" "184" "21.4" "5.11" "8.33" "3" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;other cell component" "" "Pf00498" "92610" "ENSG00000145365" "TIFA" "hsa:92610; Q96CG3" "Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway" "TAK1-dependent IKK and NF-kappa-B activation ; Alpha-protein kinase 1 signaling pathway" "4" "0" "0.985" "0.948" "0.877" "0.876" "0.994" "1.007" "0.848" "0.865" "0.804" "373.0" "367.5" "353.7" "327.1" "326.7" "370.7" "375.7" "316.3" "322.7" "299.9" "" "" "" "" "" "" "" "" "" "" "197.5" "203.7" "202.6" "150.7" "176.8" "206.2" "221.1" "172.6" "181.0" "299.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6717857941727919032" "False" "High" "IsMasterProtein" "Q8WZA9" "Immunity-related GTPase family Q protein OS=Homo sapiens OX=9606 GN=IRGQ PE=1 SV=1" "0.000" "False" "7.771" "2" "1" "1" "1" "623" "62.7" "4.88" "4.67" "1" "" "" "other molecular function" "" "126298" "ENSG00000167378" "IRGQ" "B2RNP3; hsa:126298; Q8WZA9" "" "" "0" "0" "1.091" "0.956" "1.004" "1.081" "1.019" "1.044" "0.951" "0.849" "1.278" "215.6" "235.3" "206.1" "216.6" "233.0" "219.8" "225.1" "205.2" "183.1" "275.7" "" "" "" "" "" "" "" "" "" "" "114.2" "130.5" "118.0" "99.7" "126.1" "122.3" "132.5" "112.0" "102.7" "275.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1353658345851562217" "False" "High" "IsMasterProtein" "Q9BR76" "Coronin-1B OS=Homo sapiens OX=9606 GN=CORO1B PE=1 SV=1" "0.000" "False" "7.770" "5" "3" "3" "3" "489" "54.2" "5.88" "7.41" "3" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08953, Pf16300" "57175" "ENSG00000172725" "CORO1B" "B2RD45; hsa:57175; Q9BR76" "" "" "0" "0" "0.966" "1.008" "1.037" "0.992" "1.052" "0.900" "1.017" "1.010" "1.275" "420.5" "406.2" "423.7" "436.0" "417.0" "442.4" "378.2" "427.5" "424.6" "536.3" "" "" "" "" "" "" "" "" "" "" "222.6" "225.2" "242.6" "200.8" "225.6" "246.1" "222.6" "233.4" "238.2" "536.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6335847497915133656" "False" "High" "IsMasterProtein" "Q9BTY7" "Protein HGH1 homolog OS=Homo sapiens OX=9606 GN=HGH1 PE=1 SV=1" "0.000" "False" "7.760" "7" "3" "3" "3" "390" "42.1" "4.81" "2.97" "3" "" "" "" "Pf04063, Pf04064" "51236" "ENSG00000235173" "HGH1" "hsa:51236; P0CB43; Q9BTY7" "" "" "0" "0" "1.050" "1.149" "1.324" "1.004" "0.903" "1.264" "1.000" "0.936" "2.035" "24.5" "25.7" "28.1" "32.4" "24.6" "22.1" "31.0" "24.5" "22.9" "49.8" "" "" "" "" "" "" "" "" "" "" "13.0" "14.3" "16.1" "14.9" "13.3" "12.3" "18.2" "13.4" "12.9" "49.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2096625671163089170" "False" "High" "IsMasterProtein" "O95999" "B-cell lymphoma/leukemia 10 OS=Homo sapiens OX=9606 GN=BCL10 PE=1 SV=1" "0.000" "False" "7.756" "11" "3" "4" "3" "233" "26.2" "5.74" "8.41" "3" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00619" "8915" "ENSG00000142867" "BCL10" "hsa:8915; O95999; Q5VUF1" "B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; E3 ubiquitin ligases ubiquitinate target proteins; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling" "9" "0" "0.945" "0.982" "1.268" "1.019" "0.965" "1.167" "0.938" "0.895" "0.749" "45.4" "42.9" "44.5" "57.5" "46.2" "43.8" "52.9" "42.5" "40.6" "34.0" "" "" "" "" "" "" "" "" "" "" "24.0" "23.8" "25.5" "26.5" "25.0" "24.4" "31.2" "23.2" "22.8" "34.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2014146262064774288" "False" "High" "IsMasterProtein" "P09001" "Large ribosomal subunit protein uL3m OS=Homo sapiens OX=9606 GN=MRPL3 PE=1 SV=1" "0.000" "False" "7.750" "8" "3" "4" "3" "348" "38.6" "9.48" "9.94" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00297" "11222" "ENSG00000114686" "MRPL3" "hsa:11222; P09001; Q6IBT2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6923013739007896551" "False" "High" "IsMasterProtein" "P60033" "CD81 antigen OS=Homo sapiens OX=9606 GN=CD81 PE=1 SV=1" "0.000" "False" "7.750" "8" "1" "1" "1" "236" "25.8" "5.29" "4.10" "1" "transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00335" "975" "ENSG00000110651" "CD81" "hsa:975; P18582; P60033; Q5U0J6" "B cell receptor signaling pathway; Extracellular vesicles in the crosstalk of cardiac cells; IL-18 signaling pathway; 16p11.2 distal deletion syndrome" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9158883592383283846" "False" "High" "IsMasterProtein" "P60983" "Glia maturation factor beta OS=Homo sapiens OX=9606 GN=GMFB PE=1 SV=2" "0.000" "False" "7.739" "13" "2" "2" "1" "142" "16.7" "5.29" "6.80" "2" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00241" "2764" "ENSG00000197045" "GMFB" "B2R499; hsa:2764; P17774; P60983; Q9BS35" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5185588165699995097" "False" "High" "IsMasterProtein" "P20290" "Transcription factor BTF3 OS=Homo sapiens OX=9606 GN=BTF3 PE=1 SV=1" "0.000" "False" "7.739" "10" "4" "5" "2" "206" "22.2" "9.38" "13.81" "4" "transport;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "" "Pf01849" "689" "ENSG00000145741" "BTF3" "A8K510; hsa:689; P20290; Q13893; Q76M56" "Orexin receptor pathway" "" "1" "2" "1.009" "1.275" "1.174" "0.705" "0.802" "0.664" "0.989" "0.975" "0.491" "1168.8" "1179.2" "1490.3" "1372.4" "824.2" "937.6" "775.7" "1155.8" "1139.5" "573.7" "" "" "" "" "" "" "" "" "" "" "618.9" "653.8" "853.5" "632.0" "445.9" "521.6" "456.5" "630.9" "639.2" "573.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2272350597619465793" "False" "High" "IsMasterProtein" "O00743" "Serine/threonine-protein phosphatase 6 catalytic subunit OS=Homo sapiens OX=9606 GN=PPP6C PE=1 SV=1" "0.000" "False" "7.734" "11" "3" "3" "3" "305" "35.1" "5.69" "5.85" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00149" "5537" "ENSG00000119414" "PPP6C" "B2R5V6; B7Z2W9; B7Z5K9; hsa:5537; O00743; Q5U0A2; Q9UIC9" "" "Telomere Extension By Telomerase; COPII-mediated vesicle transport" "2" "0" "0.910" "1.019" "0.898" "0.985" "0.954" "1.049" "0.974" "0.967" "0.857" "774.4" "704.8" "788.8" "695.6" "762.5" "738.6" "812.2" "754.6" "748.7" "663.5" "" "" "" "" "" "" "" "" "" "" "410.0" "390.8" "451.7" "320.3" "412.5" "410.8" "478.0" "411.9" "420.0" "663.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1707703891335855171" "False" "High" "IsMasterProtein" "Q7Z478" "ATP-dependent RNA helicase DHX29 OS=Homo sapiens OX=9606 GN=DHX29 PE=1 SV=2" "0.000" "False" "7.732" "2" "4" "4" "4" "1369" "155.1" "8.09" "10.96" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "translation activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "54505" "ENSG00000067248" "DHX29" "hsa:54505; O75549; Q63HN0; Q63HN3; Q7Z478; Q8IWW2; Q8N3A1; Q9UMH2" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.015" "1.035" "1.051" "1.012" "1.023" "0.975" "0.987" "1.034" "1.068" "691.6" "702.0" "716.0" "727.0" "699.8" "707.3" "674.1" "682.6" "715.2" "738.5" "" "" "" "" "" "" "" "" "" "" "366.2" "389.2" "410.0" "334.8" "378.6" "393.5" "396.7" "372.6" "401.2" "738.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7848560432404461068" "False" "High" "IsMasterProtein" "Q16775" "Hydroxyacylglutathione hydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=HAGH PE=1 SV=2" "0.000" "False" "7.689" "8" "2" "3" "2" "308" "33.8" "8.12" "8.48" "2" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00753, Pf16123" "3029" "ENSG00000063854" "HAGH" "A8K290; B4DP33; B4DRA7; E7EN93; hsa:3029; Q16775" "" "" "0" "0" "1.086" "1.140" "1.366" "1.078" "1.191" "1.206" "0.964" "1.086" "0.948" "172.8" "187.6" "196.9" "236.1" "186.3" "205.8" "208.3" "166.5" "187.6" "163.8" "" "" "" "" "" "" "" "" "" "" "91.5" "104.0" "112.8" "108.7" "100.8" "114.5" "122.6" "90.9" "105.2" "163.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-94552620576090045" "False" "High" "IsMasterProtein" "Q8IYM9" "E3 ubiquitin-protein ligase TRIM22 OS=Homo sapiens OX=9606 GN=TRIM22 PE=1 SV=1" "0.000" "False" "7.682" "3" "2" "2" "2" "498" "56.9" "7.72" "6.46" "2" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13445" "10346" "ENSG00000132274" "TRIM22" "hsa:10346; Q05CQ0; Q15521; Q8IYM9" "" "Interferon gamma signaling" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8843415988459270294" "False" "High" "IsMasterProtein" "Q7Z2W9" "Large ribosomal subunit protein bL21m OS=Homo sapiens OX=9606 GN=MRPL21 PE=1 SV=2" "0.000" "False" "7.671" "9" "2" "2" "2" "205" "22.8" "9.89" "7.49" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00829" "219927" "ENSG00000197345" "MRPL21" "A6NKU0; C9JPR2; hsa:219927; Q7Z2W9" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.085" "0.947" "0.953" "0.957" "0.995" "0.901" "0.675" "0.843" "1.403" "121.8" "132.1" "115.4" "116.1" "116.6" "121.2" "109.8" "82.2" "102.7" "170.9" "" "" "" "" "" "" "" "" "" "" "64.5" "73.3" "66.1" "53.5" "63.1" "67.4" "64.6" "44.9" "57.6" "170.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7727085808198553563" "False" "High" "IsMasterProtein" "P30291" "Wee1-like protein kinase OS=Homo sapiens OX=9606 GN=WEE1 PE=1 SV=2" "0.000" "False" "7.670" "6" "4" "5" "4" "646" "71.6" "6.77" "7.24" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "7465" "ENSG00000166483" "WEE1" "B3KVE1; D3DQV0; hsa:7465; P30291" "Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control" "Factors involved in megakaryocyte development and platelet production; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Cyclin A/B1/B2 associated events during G2/M transition; Polo-like kinase mediated events; G2/M DNA replication checkpoint; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "11" "0" "1.052" "1.003" "1.141" "1.025" "1.050" "1.034" "0.928" "0.914" "0.925" "186.2" "195.9" "186.8" "212.4" "190.9" "195.6" "192.6" "172.8" "170.3" "172.2" "" "" "" "" "" "" "" "" "" "" "98.6" "108.6" "107.0" "97.8" "103.3" "108.8" "113.3" "94.3" "95.5" "172.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5598137855594202811" "False" "High" "IsMasterProtein" "Q9Y6G3" "Large ribosomal subunit protein mL42 OS=Homo sapiens OX=9606 GN=MRPL42 PE=1 SV=1" "0.000" "False" "7.654" "11" "1" "1" "1" "142" "16.7" "8.35" "4.24" "1" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf10210" "28977" "ENSG00000198015" "MRPL42" "hsa:28977; Q6FID1; Q96Q48; Q9P0S1; Q9Y6G3" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.322" "0.947" "1.048" "0.827" "1.005" "1.041" "1.092" "0.906" "0.800" "79.3" "104.8" "75.1" "83.1" "65.5" "79.7" "82.5" "86.6" "71.8" "63.4" "" "" "" "" "" "" "" "" "" "" "42.0" "58.1" "43.0" "38.3" "35.5" "44.3" "48.6" "47.3" "40.3" "63.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5965244756027354747" "False" "High" "IsMasterProtein" "O75414" "Nucleoside diphosphate kinase 6 OS=Homo sapiens OX=9606 GN=NME6 PE=1 SV=3" "0.000" "False" "7.648" "13" "3" "4" "3" "186" "21.1" "8.32" "9.48" "3" "other metabolic processes;other biological processes" "mitochondrion" "kinase activity;other molecular function" "Pf00334" "10201" "ENSG00000172113" "NME6" "B4DGW7; B4DM99; hsa:10201; O75414; Q53HM5; Q96E73; Q9BQ63" "Pyrimidine metabolism" "" "1" "0" "1.066" "1.096" "1.076" "1.095" "1.024" "1.051" "1.032" "1.013" "0.614" "290.0" "309.2" "317.9" "312.0" "317.5" "297.0" "304.6" "299.2" "293.8" "178.1" "" "" "" "" "" "" "" "" "" "" "153.5" "171.4" "182.1" "143.7" "171.8" "165.2" "179.3" "163.3" "164.8" "178.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6302515266357767192" "False" "High" "IsMasterProtein" "Q9NR46" "Endophilin-B2 OS=Homo sapiens OX=9606 GN=SH3GLB2 PE=1 SV=1" "0.000" "False" "7.640" "6" "3" "3" "2" "395" "43.9" "5.99" "8.39" "3" "cell organization and biogenesis" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03114, Pf14604" "56904" "ENSG00000148341" "SH3GLB2" "A6NC47; A8MPS4; hsa:56904; Q8WY61; Q96JH9; Q9NR46" "" "" "0" "1" "1.131" "1.077" "1.256" "1.150" "1.154" "1.086" "0.276" "1.095" "11.860" "142.5" "161.2" "153.5" "178.9" "163.8" "164.4" "154.7" "39.3" "156.0" "1689.8" "" "" "" "" "" "" "" "" "" "" "75.4" "89.4" "87.9" "82.4" "88.6" "91.4" "91.0" "21.4" "87.5" "1689.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6896293366325971592" "False" "High" "IsMasterProtein" "Q8WWK9" "Cytoskeleton-associated protein 2 OS=Homo sapiens OX=9606 GN=CKAP2 PE=1 SV=1" "0.000" "False" "7.624" "3" "2" "2" "2" "683" "76.9" "9.41" "6.50" "2" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;other cell component" "" "Pf15297" "26586" "ENSG00000136108" "CKAP2" "A2BDE0; A5YM58; B4DR35; E9PD90; hsa:26586; Q3KRA5; Q5VXB4; Q8IWV5; Q8IWV6; Q8WWK9; Q96FH9; Q9H012; Q9H0D0; Q9H988; Q9HC49; Q9NVG4" "" "" "0" "0" "0.946" "1.073" "1.165" "1.022" "0.966" "1.328" "1.377" "1.274" "1.249" "237.3" "224.4" "254.7" "276.3" "242.5" "229.2" "315.1" "326.6" "302.2" "296.3" "" "" "" "" "" "" "" "" "" "" "125.6" "124.4" "145.8" "127.2" "131.2" "127.5" "185.4" "178.3" "169.5" "296.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6333223318553199487" "False" "High" "IsMasterProtein" "Q14919" "Dr1-associated corepressor OS=Homo sapiens OX=9606 GN=DRAP1 PE=1 SV=3" "0.000" "False" "7.608" "16" "2" "2" "2" "205" "22.3" "5.17" "5.92" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00808" "10589" "ENSG00000175550" "DRAP1" "hsa:10589; Q13448; Q14919" "" "Signaling by NODAL; Signaling by Activin" "2" "0" "1.156" "1.217" "0.693" "1.102" "0.970" "0.970" "1.277" "1.346" "0.733" "48.6" "56.1" "59.1" "33.7" "53.5" "47.1" "47.1" "62.0" "65.4" "35.6" "" "" "" "" "" "" "" "" "" "" "25.7" "31.1" "33.9" "15.5" "29.0" "26.2" "27.7" "33.8" "36.7" "35.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5077624206486076316" "False" "High" "IsMasterProtein" "Q8TC07" "TBC1 domain family member 15 OS=Homo sapiens OX=9606 GN=TBC1D15 PE=1 SV=2" "0.000" "False" "7.603" "5" "3" "4" "3" "691" "79.4" "5.67" "7.90" "3" "other biological processes" "non-structural extracellular;other cell component" "enzyme regulator activity" "Pf00566, Pf12068" "64786" "ENSG00000121749" "TBC1D15" "B4DMT9; B9A6L6; hsa:64786; J3KNI9; Q8TC07; Q9HA83" "" "TBC/RABGAPs" "1" "0" "0.914" "0.751" "1.174" "0.962" "0.936" "1.167" "1.043" "1.017" "2.932" "43.5" "39.8" "32.7" "51.1" "41.9" "40.8" "50.8" "45.4" "44.3" "127.7" "" "" "" "" "" "" "" "" "" "" "23.1" "22.1" "18.7" "23.5" "22.7" "22.7" "29.9" "24.8" "24.8" "127.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8044840362148842225" "False" "High" "IsMasterProtein" "O95376" "E3 ubiquitin-protein ligase ARIH2 OS=Homo sapiens OX=9606 GN=ARIH2 PE=1 SV=1" "0.000" "False" "7.601" "5" "2" "2" "2" "493" "57.8" "5.63" "6.04" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01485, Pf19422" "10425" "ENSG00000177479" "ARIH2" "hsa:10425; O95376; Q9HBZ6; Q9UEM9" "Modulators of TCR signaling and T cell activation" "Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "0.997" "0.907" "1.111" "1.145" "1.255" "1.136" "1.106" "1.302" "1.276" "169.8" "169.2" "154.0" "188.6" "194.3" "213.1" "192.9" "187.8" "221.1" "216.6" "" "" "" "" "" "" "" "" "" "" "89.9" "93.8" "88.2" "86.8" "105.1" "118.5" "113.5" "102.5" "124.0" "216.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4819248738273411506" "False" "High" "IsMasterProtein" "O14981" "TATA-binding protein-associated factor 172 OS=Homo sapiens OX=9606 GN=BTAF1 PE=1 SV=2" "0.000" "False" "7.594" "2" "3" "3" "3" "1849" "206.8" "6.52" "7.49" "3" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf12054" "9044" "ENSG00000095564" "BTAF1" "B4E0W6; hsa:9044; O14981; O43578" "" "" "0" "0" "1.077" "1.020" "1.040" "0.938" "0.966" "0.883" "1.160" "0.964" "2.433" "96.7" "104.1" "98.6" "100.6" "90.7" "93.5" "85.5" "112.2" "93.3" "235.3" "" "" "" "" "" "" "" "" "" "" "51.2" "57.7" "56.5" "46.3" "49.1" "52.0" "50.3" "61.3" "52.3" "235.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-843135532772952093" "False" "High" "IsMasterProtein" "Q8TD55" "Pleckstrin homology domain-containing family O member 2 OS=Homo sapiens OX=9606 GN=PLEKHO2 PE=1 SV=1" "0.000" "False" "7.574" "6" "3" "3" "3" "490" "53.3" "5.43" "8.47" "3" "other biological processes" "non-structural extracellular;other cell component" "" "Pf00169" "80301" "ENSG00000241839" "PLEKHO2" "hsa:80301; Q7L4H4; Q8TD55; Q8WYS8" "" "Neutrophil degranulation" "1" "0" "1.134" "0.985" "1.094" "1.522" "1.190" "1.030" "0.897" "1.173" "0.842" "253.7" "287.6" "249.7" "277.4" "386.1" "302.0" "261.3" "227.6" "297.5" "213.6" "" "" "" "" "" "" "" "" "" "" "134.3" "159.4" "143.0" "127.8" "208.9" "168.0" "153.8" "124.2" "166.9" "213.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-985839782283071822" "False" "High" "IsMasterProtein" "P10619" "Lysosomal protective protein OS=Homo sapiens OX=9606 GN=CTSA PE=1 SV=2" "0.000" "False" "7.571" "3" "1" "1" "1" "480" "54.4" "6.61" "3.93" "1" "protein metabolism;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00450" "5476" "ENSG00000064601" "CTSA" "B2R798; hsa:5476; P10619; Q561W6; Q5JZH1; Q96KJ2; Q9BR08; Q9BW68" "Ciliary landscape" "MHC class II antigen presentation; Neutrophil degranulation; Sialic acid metabolism; Glycosphingolipid catabolism; Defective NEU1 causes sialidosis" "6" "0" "0.929" "0.896" "0.904" "0.935" "0.947" "0.810" "0.982" "0.908" "0.608" "244.5" "227.3" "219.1" "221.0" "228.7" "231.5" "198.2" "240.1" "222.0" "148.6" "" "" "" "" "" "" "" "" "" "" "129.5" "126.0" "125.5" "101.8" "123.7" "128.8" "116.6" "131.0" "124.5" "148.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8579706144891720478" "False" "High" "IsMasterProtein" "O00267" "Transcription elongation factor SPT5 OS=Homo sapiens OX=9606 GN=SUPT5H PE=1 SV=1" "0.000" "False" "7.565" "2" "2" "2" "2" "1087" "120.9" "5.06" "5.84" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00467, Pf03439, Pf11942" "6829" "ENSG00000196235" "SUPT5H" "hsa:6829; O00267; O43279; Q59G52; Q99639" "Initiation of transcription and translation elongation at the HIV-1 LTR; mRNA processing" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE" "20" "0" "1.217" "1.057" "1.334" "1.287" "1.191" "1.165" "1.069" "1.087" "1.553" "52.0" "63.3" "54.9" "69.4" "66.9" "61.9" "60.6" "55.6" "56.5" "80.7" "" "" "" "" "" "" "" "" "" "" "27.5" "35.1" "31.5" "31.9" "36.2" "34.4" "35.6" "30.3" "31.7" "80.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5006297447401564784" "False" "High" "IsMasterProtein" "Q96B23" "Protein ARK2N OS=Homo sapiens OX=9606 GN=ARK2N PE=1 SV=3" "0.000" "False" "7.562" "5" "2" "2" "2" "404" "43.4" "4.88" "6.21" "2" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf15303" "147339" "ENSG00000152242" "ARK2N" "A8K123; A8KAB6; hsa:147339; Q5BIX2; Q5XG78; Q6N058; Q86TB5; Q8TCQ5; Q96B23" "" "" "0" "0" "1.041" "1.258" "1.503" "1.000" "0.979" "1.697" "1.242" "1.107" "1.198" "33.3" "34.7" "41.9" "50.1" "33.3" "32.6" "56.5" "41.4" "36.9" "39.9" "" "" "" "" "" "" "" "" "" "" "17.6" "19.2" "24.0" "23.1" "18.0" "18.1" "33.3" "22.6" "20.7" "39.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8069995448672304033" "False" "High" "IsMasterProtein" "P01703" "Immunoglobulin lambda variable 1-40 OS=Homo sapiens OX=9606 GN=IGLV1-40 PE=1 SV=2" "0.000" "False" "7.550" "14" "1" "1" "1" "118" "12.3" "5.74" "3.76" "1" "other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf07686" "" "ENSG00000211653; ENSG00000274575" "IGLV1-40" "A0A075B6J0; P01703" "" "FCERI mediated MAPK activation; FCERI mediated NF-kB activation; Initial triggering of complement; Classical antibody-mediated complement activation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Scavenging of heme from plasma; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated Ca+2 mobilization; CD22 mediated BCR regulation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Potential therapeutics for SARS; Regulation of Complement cascade; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "19" "0" "1.023" "1.161" "1.030" "0.785" "0.893" "0.841" "1.022" "0.891" "1.144" "148.5" "151.9" "172.4" "152.9" "116.5" "132.6" "124.9" "151.8" "132.3" "169.8" "" "" "" "" "" "" "" "" "" "" "78.6" "84.2" "98.8" "70.4" "63.0" "73.8" "73.5" "82.9" "74.2" "169.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6462118287367883221" "False" "High" "IsMasterProtein" "Q9Y296" "Trafficking protein particle complex subunit 4 OS=Homo sapiens OX=9606 GN=TRAPPC4 PE=1 SV=1" "0.000" "False" "7.547" "8" "2" "2" "2" "219" "24.3" "6.21" "6.06" "2" "cell organization and biogenesis;other metabolic processes;transport;developmental processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04099" "51399" "ENSG00000196655; ENSG00000280495" "TRAPPC4" "A8K3A5; B4DME1; hsa:51399; Q9Y296" "" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport; Syndecan interactions" "3" "0" "1.170" "0.976" "1.033" "1.075" "1.191" "1.132" "1.032" "1.132" "1.166" "213.9" "250.4" "208.8" "220.9" "229.9" "254.8" "242.1" "220.8" "242.1" "249.3" "" "" "" "" "" "" "" "" "" "" "113.3" "138.8" "119.6" "101.7" "124.4" "141.7" "142.5" "120.5" "135.8" "249.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7232907791819213920" "False" "High" "IsMasterProtein" "Q9Y5Z4" "Heme-binding protein 2 OS=Homo sapiens OX=9606 GN=HEBP2 PE=1 SV=1" "0.000" "False" "7.530" "14" "3" "3" "3" "205" "22.9" "4.63" "6.27" "3" "" "non-structural extracellular;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04832" "23593" "ENSG00000051620" "HEBP2" "hsa:23593; Q96P57; Q9Y5Z4" "" "Neutrophil degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4832137807520605002" "False" "High" "IsMasterProtein" "O60934" "Nibrin OS=Homo sapiens OX=9606 GN=NBN PE=1 SV=1" "0.000" "False" "7.529" "3" "2" "2" "2" "754" "84.9" "6.90" "4.78" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00498, Pf00533, Pf08599, Pf16508" "4683" "ENSG00000104320" "NBN" "B2R626; B2RNC5; hsa:4683; O60672; O60934; Q32NF7; Q53FM6; Q63HR6; Q7LDM2" "miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Primary ovarian insufficiency; DNA damage response" "Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks" "29" "0" "1.129" "1.108" "1.018" "1.056" "1.177" "0.939" "0.678" "1.098" "3.208" "25.3" "28.6" "28.0" "25.7" "26.7" "29.8" "23.7" "17.1" "27.8" "81.1" "" "" "" "" "" "" "" "" "" "" "13.4" "15.8" "16.0" "11.9" "14.4" "16.6" "14.0" "9.4" "15.6" "81.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3838187860165332500" "False" "High" "IsMasterProtein" "P52564" "Dual specificity mitogen-activated protein kinase kinase 6 OS=Homo sapiens OX=9606 GN=MAP2K6 PE=1 SV=1" "0.000" "False" "7.517" "6" "2" "2" "1" "334" "37.5" "7.39" "5.38" "2" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5608" "ENSG00000108984" "MAP2K6" "hsa:5608; P52564" "MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Photodynamic therapy-induced AP-1 survival signaling; TGF-beta signaling pathway; MAPK signaling pathway; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; p38 MAPK signaling pathway; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; 16p11.2 proximal deletion syndrome; Angiotensin II receptor type 1 pathway; Pleural mesothelioma; GNAQ pathways in port-wine stain; Interferon type I signaling pathways; Serotonin HTR1 group and FOS pathway; Toll-like receptor signaling pathway" "PKR-mediated signaling; NOD1/2 Signaling Pathway; Interleukin-1 signaling; Oxidative Stress Induced Senescence; Myogenesis; activated TAK1 mediates p38 MAPK activation; PI5P Regulates TP53 Acetylation" "41" "0" "1.011" "0.869" "1.627" "0.974" "0.952" "1.263" "0.931" "0.723" "0.582" "72.0" "72.8" "62.5" "117.2" "70.2" "68.5" "90.9" "67.0" "52.1" "41.9" "" "" "" "" "" "" "" "" "" "" "38.1" "40.3" "35.8" "54.0" "38.0" "38.1" "53.5" "36.6" "29.2" "41.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8213729863308039280" "False" "High" "IsMasterProtein" "Q14331" "Protein FRG1 OS=Homo sapiens OX=9606 GN=FRG1 PE=1 SV=1" "0.000" "False" "7.516" "10" "2" "2" "2" "258" "29.2" "9.01" "5.78" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus" "cytoskeletal activity" "Pf06229" "2483" "ENSG00000109536; ENSG00000275145; ENSG00000283153; ENSG00000283630" "FRG1" "A8K775; hsa:2483; Q14331" "" "" "0" "0" "1.001" "1.135" "0.914" "0.959" "1.030" "0.964" "0.919" "0.831" "1.147" "288.0" "288.2" "326.9" "263.3" "276.1" "296.5" "277.5" "264.6" "239.4" "330.4" "" "" "" "" "" "" "" "" "" "" "152.5" "159.8" "187.2" "121.3" "149.4" "164.9" "163.3" "144.4" "134.3" "330.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3954168667574221268" "False" "High" "IsMasterProtein" "Q9H1J1" "Regulator of nonsense transcripts 3A OS=Homo sapiens OX=9606 GN=UPF3A PE=1 SV=1" "0.000" "False" "7.499" "2" "1" "1" "1" "476" "54.7" "9.03" "4.11" "1" "transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf03467" "65110" "ENSG00000169062" "UPF3A" "A2A366; hsa:65110; Q5T8C3; Q5T8C9; Q7Z6N3; Q86YK1; Q9BZI8; Q9H1J1" "" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "2" "0" "0.951" "0.982" "0.871" "1.190" "0.968" "1.129" "0.900" "1.190" "0.825" "101.1" "96.2" "99.3" "88.1" "120.4" "97.9" "114.2" "91.1" "120.4" "83.4" "" "" "" "" "" "" "" "" "" "" "53.6" "53.3" "56.9" "40.6" "65.1" "54.5" "67.2" "49.7" "67.5" "83.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6527665309278316816" "False" "High" "IsMasterProtein" "O15145" "Actin-related protein 2/3 complex subunit 3 OS=Homo sapiens OX=9606 GN=ARPC3 PE=1 SV=3" "0.000" "False" "7.492" "14" "3" "3" "3" "178" "20.5" "8.59" "7.60" "3" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf04062" "10094" "ENSG00000111229" "ARPC3" "hsa:10094; O00554; O15145" "Pathogenic Escherichia coli infection" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "6" "0" "1.066" "1.235" "1.244" "1.099" "1.084" "0.874" "1.173" "1.029" "0.603" "110.4" "117.7" "136.3" "137.3" "121.3" "119.6" "96.4" "129.5" "113.6" "66.5" "" "" "" "" "" "" "" "" "" "" "58.4" "65.2" "78.0" "63.2" "65.6" "66.5" "56.8" "70.7" "63.7" "66.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8750059555873910244" "False" "High" "IsMasterProtein" "Q96KB5" "Lymphokine-activated killer T-cell-originated protein kinase OS=Homo sapiens OX=9606 GN=PBK PE=1 SV=3" "0.000" "False" "7.490" "7" "2" "2" "2" "322" "36.1" "5.12" "2.64" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "kinase activity;other molecular function" "Pf00069" "55872" "ENSG00000168078" "PBK" "B4DX68; D3DST2; hsa:55872; Q96KB5; Q9NPD9; Q9NYL7; Q9NZK6" "4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling" "" "2" "0" "0.935" "1.229" "1.274" "1.187" "1.329" "1.121" "0.951" "1.412" "2.953" "54.0" "50.5" "66.3" "68.8" "64.1" "71.8" "60.5" "51.3" "76.2" "159.4" "" "" "" "" "" "" "" "" "" "" "28.6" "28.0" "38.0" "31.7" "34.7" "39.9" "35.6" "28.0" "42.8" "159.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2530096589731876058" "False" "High" "IsMasterProtein" "Q96EK5" "KIF-binding protein OS=Homo sapiens OX=9606 GN=KIFBP PE=1 SV=1" "0.000" "False" "7.463" "3" "2" "3" "1" "621" "71.8" "5.49" "8.68" "2" "cell organization and biogenesis;transport;developmental processes" "cytoskeleton;mitochondrion" "cytoskeletal activity" "Pf12309" "26128" "ENSG00000198954" "KIFBP" "A8K5M8; Q96EK5; Q9BR89; Q9ULE1; Q9Y428" "" "" "0" "0" "0.944" "0.879" "0.897" "0.991" "0.931" "0.876" "0.684" "0.890" "2.678" "137.9" "130.2" "121.1" "123.7" "136.7" "128.3" "120.7" "94.4" "122.7" "369.3" "" "" "" "" "" "" "" "" "" "" "73.0" "72.2" "69.4" "56.9" "74.0" "71.4" "71.0" "51.5" "68.8" "369.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "841386405994122390" "False" "High" "IsMasterProtein" "Q92785" "Zinc finger protein ubi-d4 OS=Homo sapiens OX=9606 GN=DPF2 PE=1 SV=2" "0.000" "False" "7.446" "6" "2" "2" "2" "391" "44.1" "6.33" "5.12" "2" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00628, Pf14051" "5977" "ENSG00000133884" "DPF2" "A8K7C9; B4DT58; hsa:5977; Q92785" "Tumor suppressor activity of SMARCB1" "" "1" "0" "0.897" "0.832" "1.263" "0.970" "0.789" "0.804" "0.821" "1.079" "1.040" "23.6" "21.1" "19.6" "29.8" "22.9" "18.6" "19.0" "19.4" "25.4" "24.5" "" "" "" "" "" "" "" "" "" "" "12.5" "11.7" "11.2" "13.7" "12.4" "10.4" "11.2" "10.6" "14.3" "24.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "29627463948576905" "False" "High" "IsMasterProtein" "Q9NUQ8" "ATP-binding cassette sub-family F member 3 OS=Homo sapiens OX=9606 GN=ABCF3 PE=1 SV=2" "0.000" "False" "7.438" "3" "2" "2" "2" "709" "79.7" "6.34" "5.12" "2" "stress response" "" "other molecular function" "Pf00005, Pf12848" "55324" "ENSG00000161204" "ABCF3" "A8K241; hsa:55324; Q86UA2; Q8NAN1; Q96GS8; Q9H7A8; Q9NUQ8" "" "" "0" "0" "1.085" "1.005" "1.168" "0.943" "0.847" "0.961" "1.037" "0.902" "1.703" "47.4" "51.4" "47.6" "55.3" "44.7" "40.1" "45.5" "49.1" "42.7" "80.7" "" "" "" "" "" "" "" "" "" "" "25.1" "28.5" "27.3" "25.5" "24.2" "22.3" "26.8" "26.8" "24.0" "80.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6447964159336659836" "False" "High" "IsMasterProtein" "Q9UL15" "BAG family molecular chaperone regulator 5 OS=Homo sapiens OX=9606 GN=BAG5 PE=1 SV=1" "0.000" "False" "7.435" "5" "2" "2" "2" "447" "51.2" "6.05" "5.54" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf02179" "9529" "ENSG00000166170" "BAG5" "hsa:9529; O94950; Q86W59; Q9UL15" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "0.822" "1.034" "1.214" "0.882" "1.075" "1.051" "0.681" "1.099" "4.742" "109.4" "89.9" "113.1" "132.8" "96.5" "117.6" "114.9" "74.5" "120.2" "518.7" "" "" "" "" "" "" "" "" "" "" "57.9" "49.8" "64.8" "61.2" "52.2" "65.4" "67.7" "40.6" "67.4" "518.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8841381739766448706" "False" "High" "IsMasterProtein" "Q2M296" "Methenyltetrahydrofolate synthase domain-containing protein OS=Homo sapiens OX=9606 GN=MTHFSD PE=1 SV=2" "0.000" "False" "7.427" "7" "3" "4" "3" "383" "42.1" "8.73" "10.85" "3" "" "other cell component" "" "Pf00076, Pf01812" "64779" "ENSG00000103248" "MTHFSD" "A8MQ77; B7ZLC0; B7ZLC2; D3DUM9; E9PAM1; hsa:64779; Q2M296; Q9H878; Q9H954" "" "" "0" "0" "1.083" "0.907" "1.099" "1.062" "1.000" "1.063" "0.952" "0.885" "0.719" "375.2" "406.5" "340.3" "412.3" "398.5" "375.3" "398.7" "357.1" "332.2" "269.7" "" "" "" "" "" "" "" "" "" "" "198.7" "225.4" "194.9" "189.9" "215.6" "208.8" "234.7" "194.9" "186.4" "269.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "514790625548438605" "False" "High" "IsMasterProtein" "Q8WUX2" "Glutathione-specific gamma-glutamylcyclotransferase 2 OS=Homo sapiens OX=9606 GN=CHAC2 PE=1 SV=1" "0.000" "False" "7.426" "13" "2" "2" "2" "184" "20.9" "5.43" "6.08" "2" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf04752" "494143" "ENSG00000143942" "CHAC2" "hsa:494143; Q8WUX2; Q8WVI8" "" "Glutathione synthesis and recycling" "1" "0" "1.056" "0.938" "0.844" "0.968" "0.996" "0.938" "0.943" "0.904" "0.822" "516.5" "545.4" "484.5" "436.1" "499.9" "514.3" "484.4" "486.9" "467.1" "424.6" "" "" "" "" "" "" "" "" "" "" "273.5" "302.4" "277.4" "200.9" "270.5" "286.1" "285.1" "265.8" "262.0" "424.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3305508852960409357" "False" "High" "IsMasterProtein" "Cont_Q7SIH1" "Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2" "0.000" "True" "7.423" "1" "2" "2" "2" "1510" "167.5" "6.02" "5.90" "2" "" "non-structural extracellular" "enzyme regulator activity;other molecular function" "Pf00207, Pf01835, Pf07677, Pf07678, Pf07703, Pf17789, Pf17791" "513856" "" "A2M" "A8E647; bta:513856; Q7SIH1" "" "" "0" "0" "1.054" "1.053" "1.124" "1.466" "1.450" "1.197" "1.512" "1.624" "0.763" "85.1" "89.7" "89.6" "95.6" "124.7" "123.4" "101.9" "128.6" "138.1" "64.9" "" "" "" "" "" "" "" "" "" "" "45.1" "49.7" "51.3" "44.0" "67.5" "68.6" "60.0" "70.2" "77.5" "64.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3178523695898665962" "False" "High" "IsMasterProtein" "Q9NYF8" "Bcl-2-associated transcription factor 1 OS=Homo sapiens OX=9606 GN=BCLAF1 PE=1 SV=2" "0.000" "False" "7.420" "2" "2" "2" "2" "920" "106.1" "9.98" "5.86" "2" "stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15440" "9774" "ENSG00000029363" "BCLAF1" "A2RU75; B7ZM58; E1P586; hsa:9774; Q14673; Q86WU6; Q86WY0; Q9NYF8" "Interactome of polycomb repressive complex 2 (PRC2)" "" "1" "0" "0.945" "1.020" "0.981" "1.111" "1.055" "1.270" "1.744" "1.695" "0.864" "248.4" "234.8" "253.5" "243.8" "276.1" "262.1" "315.6" "433.4" "421.0" "214.7" "" "" "" "" "" "" "" "" "" "" "131.5" "130.2" "145.2" "112.3" "149.4" "145.8" "185.7" "236.6" "236.2" "214.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3338073365584811594" "False" "High" "IsMasterProtein" "P83731" "Large ribosomal subunit protein eL24 OS=Homo sapiens OX=9606 GN=RPL24 PE=1 SV=1" "0.000" "False" "7.419" "10" "2" "4" "2" "157" "17.8" "11.25" "10.09" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01246" "6152" "ENSG00000114391" "RPL24" "B2R4Y3; hsa:6152; P38663; P83731; Q6IBS3" "Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.075" "1.043" "1.113" "1.082" "1.254" "1.112" "0.954" "1.244" "2.188" "487.5" "523.9" "508.3" "542.7" "527.6" "611.1" "542.3" "465.0" "606.3" "1066.7" "" "" "" "" "" "" "" "" "" "" "258.1" "290.5" "291.1" "250.0" "285.4" "339.9" "319.1" "253.8" "340.1" "1066.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8207864549745438201" "False" "High" "IsMasterProtein" "Q96T76" "MMS19 nucleotide excision repair protein homolog OS=Homo sapiens OX=9606 GN=MMS19 PE=1 SV=2" "0.000" "False" "7.416" "3" "2" "2" "2" "1030" "113.2" "6.35" "3.40" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf12460, Pf14500" "64210" "ENSG00000155229" "MMS19" "B0QZ75; B3KPE5; B4DQX2; B4E2I3; D3DR55; F8W9Y2; hsa:64210; Q17RZ8; Q5T455; Q66K82; Q7L4W8; Q969Z1; Q96DF1; Q96MR1; Q96RK5; Q96SK1; Q96T76; Q9BUE2; Q9BYS9" "2q11.2 copy number variation syndrome" "Cytosolic iron-sulfur cluster assembly" "2" "0" "1.057" "1.137" "1.186" "1.382" "1.050" "1.171" "0.980" "0.911" "1.243" "44.8" "47.3" "50.9" "53.1" "61.8" "47.0" "52.4" "43.9" "40.8" "55.6" "" "" "" "" "" "" "" "" "" "" "23.7" "26.2" "29.1" "24.5" "33.5" "26.1" "30.8" "23.9" "22.9" "55.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3725615404801325538" "False" "High" "IsMasterProtein" "Q9UJX3" "Anaphase-promoting complex subunit 7 OS=Homo sapiens OX=9606 GN=ANAPC7 PE=1 SV=5" "0.000" "False" "7.406" "4" "2" "2" "2" "565" "63.1" "5.72" "5.58" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf13181" "" "ENSG00000196510" "ANAPC7" "Q96AC4; Q96GF4; Q9BU24; Q9NT16; Q9UJX3" "Cell cycle" "Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; APC/C:Cdc20 mediated degradation of Cyclin B; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Inactivation of APC/C via direct inhibition of the APC/C complex; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "1.219" "1.117" "1.137" "1.241" "0.936" "1.099" "0.899" "1.100" "2.892" "103.6" "126.3" "115.6" "117.7" "128.5" "97.0" "113.8" "93.1" "113.9" "299.5" "" "" "" "" "" "" "" "" "" "" "54.8" "70.0" "66.2" "54.2" "69.5" "53.9" "67.0" "50.8" "63.9" "299.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-200305812606160804" "False" "High" "IsMasterProtein" "Q3MHD2" "Protein LSM12 OS=Homo sapiens OX=9606 GN=LSM12 PE=1 SV=2" "0.000" "False" "7.399" "9" "2" "3" "2" "195" "21.7" "7.74" "10.08" "2" "" "other cell component" "nucleic acid binding activity" "Pf09793, Pf21166" "124801" "ENSG00000161654" "LSM12" "hsa:124801; Q3MHD2; Q86YB1; Q96NL5" "" "" "0" "0" "1.074" "1.116" "1.049" "0.842" "0.963" "0.749" "1.201" "1.042" "0.798" "289.6" "311.0" "323.3" "303.8" "243.8" "278.9" "216.8" "347.8" "301.7" "231.1" "" "" "" "" "" "" "" "" "" "" "153.3" "172.4" "185.1" "139.9" "131.9" "155.1" "127.6" "189.9" "169.2" "231.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8338185896590092974" "False" "High" "IsMasterProtein" "Q9H0B6" "Kinesin light chain 2 OS=Homo sapiens OX=9606 GN=KLC2 PE=1 SV=1" "0.000" "False" "7.396" "4" "3" "3" "1" "622" "68.9" "7.15" "6.66" "3" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf13424" "64837" "ENSG00000174996" "KLC2" "A8MXL7; B2RDY4; hsa:64837; Q9H0B6; Q9H9C8; Q9HA20" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; RHO GTPases activate KTN1" "6" "0" "0.717" "1.034" "1.036" "1.347" "0.750" "1.266" "1.363" "1.247" "2.522" "27.9" "20.0" "28.8" "28.9" "37.6" "20.9" "35.3" "38.0" "34.8" "70.3" "" "" "" "" "" "" "" "" "" "" "14.8" "11.1" "16.5" "13.3" "20.3" "11.6" "20.8" "20.8" "19.5" "70.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3431130476793294573" "False" "High" "IsMasterProtein" "Q8IUR0" "Trafficking protein particle complex subunit 5 OS=Homo sapiens OX=9606 GN=TRAPPC5 PE=1 SV=1" "0.000" "False" "7.393" "10" "2" "3" "2" "188" "20.8" "9.66" "8.01" "2" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04051" "126003" "ENSG00000181029" "TRAPPC5" "A8K7I6; hsa:126003; Q8IUR0" "" "COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs" "2" "0" "0.931" "0.993" "1.092" "1.122" "0.949" "1.090" "0.934" "0.861" "1.198" "82.1" "76.4" "81.5" "89.7" "92.1" "77.9" "89.5" "76.7" "70.6" "98.3" "" "" "" "" "" "" "" "" "" "" "43.5" "42.3" "46.7" "41.3" "49.8" "43.3" "52.7" "41.9" "39.6" "98.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5023215591343920566" "False" "High" "IsMasterProtein" "Q12768" "WASH complex subunit 5 OS=Homo sapiens OX=9606 GN=WASHC5 PE=1 SV=1" "0.000" "False" "7.392" "2" "3" "3" "3" "1159" "134.2" "6.98" "6.69" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf10266" "9897" "ENSG00000164961" "WASHC5" "A8K4R7; hsa:9897; Q12768; Q3KQX5; Q8TBQ2" "" "" "0" "0" "1.115" "0.961" "1.126" "1.213" "1.151" "1.140" "0.749" "1.042" "3.744" "95.9" "106.9" "92.2" "108.0" "116.3" "110.4" "109.3" "71.8" "99.9" "359.1" "" "" "" "" "" "" "" "" "" "" "50.8" "59.3" "52.8" "49.7" "62.9" "61.4" "64.3" "39.2" "56.1" "359.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5083710564544014092" "False" "High" "IsMasterProtein" "P84103" "Serine/arginine-rich splicing factor 3 OS=Homo sapiens OX=9606 GN=SRSF3 PE=1 SV=1" "0.000" "False" "7.392" "18" "3" "9" "2" "164" "19.3" "11.65" "15.61" "3" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6428" "ENSG00000112081" "SRSF3" "B4E241; hsa:6428; O08831; P23152; P84103; Q5R3K0" "mRNA processing" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "6" "0" "1.016" "1.024" "0.985" "0.981" "0.956" "0.974" "0.998" "0.956" "0.474" "610.9" "620.6" "625.4" "602.0" "599.3" "584.1" "594.8" "609.9" "584.0" "289.4" "" "" "" "" "" "" "" "" "" "" "323.5" "344.1" "358.2" "277.2" "324.3" "324.9" "350.1" "332.9" "327.6" "289.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4643868144451564503" "False" "High" "IsMasterProtein" "P41567" "Eukaryotic translation initiation factor 1 OS=Homo sapiens OX=9606 GN=EIF1 PE=1 SV=1" "0.000" "False" "7.386" "27" "2" "3" "2" "113" "12.7" "7.44" "9.03" "2" "protein metabolism;other metabolic processes;other biological processes" "translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf01253" "10209" "ENSG00000173812" "EIF1" "hsa:10209; P41567; Q9UNQ9" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "" "2" "0" "0.875" "1.111" "1.005" "0.974" "0.929" "0.945" "1.056" "0.915" "0.467" "273.3" "239.2" "303.7" "274.7" "266.1" "253.9" "258.2" "288.7" "250.0" "127.7" "" "" "" "" "" "" "" "" "" "" "144.7" "132.6" "173.9" "126.5" "144.0" "141.2" "152.0" "157.6" "140.2" "127.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4012099030302879857" "False" "High" "IsMasterProtein" "P49137" "MAP kinase-activated protein kinase 2 OS=Homo sapiens OX=9606 GN=MAPKAPK2 PE=1 SV=1" "0.000" "False" "7.374" "7" "3" "5" "2" "400" "45.5" "8.68" "13.06" "3" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "9261" "ENSG00000162889" "MAPKAPK2" "hsa:9261; P49137; Q5SY30; Q5SY41; Q8IYD6" "IL-1 signaling pathway; Microtubule cytoskeleton regulation; Interleukin-1 (IL-1) structural pathway; Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; VEGFA-VEGFR2 signaling; p38 MAPK signaling pathway; Pleural mesothelioma; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling" "VEGFA-VEGFR2 Pathway; Regulation of HSF1-mediated heat shock response; Oxidative Stress Induced Senescence; Regulation of TNFR1 signaling; p38MAPK events; activated TAK1 mediates p38 MAPK activation; CREB phosphorylation; Synthesis of Leukotrienes (LT) and Eoxins (EX); Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "21" "1" "1.018" "0.935" "0.889" "0.906" "0.960" "0.803" "0.848" "0.826" "0.891" "701.5" "714.2" "655.7" "623.9" "635.9" "673.2" "563.4" "594.6" "579.4" "625.3" "" "" "" "" "" "" "" "" "" "" "371.5" "395.9" "375.5" "287.3" "344.0" "374.4" "331.6" "324.6" "325.1" "625.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4874402221689570626" "False" "High" "IsMasterProtein" "Q86W56" "Poly(ADP-ribose) glycohydrolase OS=Homo sapiens OX=9606 GN=PARG PE=1 SV=1" "0.000" "False" "7.374" "3" "2" "2" "2" "976" "111.0" "6.43" "5.91" "2" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf05028, Pf20811" "670; 8505" "ENSG00000227345" "PARG" "A5YBK3; B2RC24; B4DIU5; B4DYR4; hsa:8505; I6RUV3; Q6E4P6; Q6E4P7; Q7Z742; Q86W56; Q9Y4W7" "10q11.21q11.23 copy number variation syndrome" "POLB-Dependent Long Patch Base Excision Repair" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-684970281821863116" "False" "High" "IsMasterProtein" "Q9BXW9" "Fanconi anemia group D2 protein OS=Homo sapiens OX=9606 GN=FANCD2 PE=1 SV=2" "0.000" "False" "7.370" "2" "3" "3" "3" "1451" "164.0" "5.88" "5.39" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf14631" "2177" "ENSG00000144554" "FANCD2" "hsa:2177; Q2LA86; Q69YP9; Q6PJN7; Q9BQ06; Q9BXW9; Q9H9T9" "miRNA regulation of DNA damage response; 15q13.3 copy number variation syndrome; DNA repair pathways, full network; 15q11q13 copy number variation; DNA damage response" "TP53 Regulates Transcription of DNA Repair Genes; Fanconi Anemia Pathway" "7" "0" "0.984" "1.092" "1.011" "0.954" "0.837" "0.720" "0.662" "0.732" "2.081" "117.6" "115.7" "128.4" "118.9" "112.2" "98.5" "84.7" "77.9" "86.1" "244.8" "" "" "" "" "" "" "" "" "" "" "62.3" "64.2" "73.5" "54.8" "60.7" "54.8" "49.8" "42.5" "48.3" "244.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8170052287552769839" "False" "High" "IsMasterProtein" "Q13905" "Rap guanine nucleotide exchange factor 1 OS=Homo sapiens OX=9606 GN=RAPGEF1 PE=1 SV=3" "0.000" "False" "7.369" "2" "2" "2" "2" "1077" "120.5" "5.92" "7.02" "2" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00617, Pf00618" "2889" "ENSG00000107263" "RAPGEF1" "hsa:2889; Q13905; Q5JUE4; Q68DL3; Q8IV73" "Integrin-mediated cell adhesion; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; IL-3 signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; MET in type 1 papillary renal cell carcinoma; Insulin signaling; Interferon type I signaling pathways" "RAC3 GTPase cycle; Regulation of signaling by CBL; Downstream signal transduction; Erythropoietin activates RAS; Frs2-mediated activation; MET activates RAP1 and RAC1" "17" "0" "1.082" "0.884" "1.206" "1.248" "1.071" "1.718" "1.872" "1.720" "2.351" "109.8" "118.8" "97.1" "132.4" "137.0" "117.5" "188.6" "205.5" "188.8" "258.1" "" "" "" "" "" "" "" "" "" "" "58.1" "65.9" "55.6" "61.0" "74.1" "65.4" "111.0" "112.2" "105.9" "258.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7227303497452228744" "False" "High" "IsMasterProtein" "Q9P0S2" "Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=COX16 PE=1 SV=1" "0.000" "False" "7.366" "8" "1" "2" "1" "106" "12.3" "9.50" "6.04" "1" "cell organization and biogenesis" "other membranes;mitochondrion" "" "Pf14138" "51241" "ENSG00000133983" "COX16" "A6NDT5; A8K3X8; B8XYC5; hsa:51241; Q9P0S2" "Mitochondrial complex IV assembly" "Cytoprotection by HMOX1; TP53 Regulates Metabolic Genes; Respiratory electron transport" "4" "0" "0.937" "1.031" "0.994" "0.968" "0.881" "0.885" "0.965" "0.905" "0.250" "226.8" "212.6" "233.8" "225.5" "219.6" "199.8" "200.8" "218.8" "205.3" "56.7" "" "" "" "" "" "" "" "" "" "" "120.1" "117.9" "133.9" "103.8" "118.8" "111.2" "118.1" "119.4" "115.2" "56.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8485123881553311665" "False" "High" "IsMasterProtein" "Q8TEB1" "DDB1- and CUL4-associated factor 11 OS=Homo sapiens OX=9606 GN=DCAF11 PE=1 SV=1" "0.000" "False" "7.366" "4" "2" "3" "2" "546" "61.6" "6.40" "9.69" "2" "protein metabolism;other metabolic processes" "nucleus;other cell component" "" "Pf00400" "80344" "ENSG00000100897; ENSG00000284796" "DCAF11" "B3KQ83; D3DS56; hsa:80344; Q5D039; Q86U00; Q86U39; Q8NDN2; Q8TEB1; Q9H2J0; Q9H3A3; Q9H5C9" "Ciliary landscape" "Neddylation" "2" "0" "1.622" "1.658" "1.302" "1.320" "1.646" "1.352" "1.721" "1.427" "1.413" "25.5" "41.4" "42.3" "33.2" "33.7" "42.0" "34.5" "43.9" "36.4" "36.1" "" "" "" "" "" "" "" "" "" "" "13.5" "23.0" "24.2" "15.3" "18.2" "23.4" "20.3" "24.0" "20.4" "36.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3602671086497481481" "False" "High" "IsMasterProtein" "O43709" "18S rRNA (guanine-N(7))-methyltransferase OS=Homo sapiens OX=9606 GN=BUD23 PE=1 SV=2" "0.000" "False" "7.357" "7" "2" "2" "2" "281" "31.9" "8.73" "7.50" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf08241, Pf12589" "114049" "ENSG00000071462" "BUD23" "A8K501; C9K060; hsa:114049; O43709; Q96P12; Q9BQ58; Q9HBP9" "7q11.23 copy number variation syndrome" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "3" "0" "1.017" "0.963" "0.991" "1.122" "0.976" "0.956" "0.937" "1.039" "0.768" "383.5" "390.1" "369.4" "380.0" "430.1" "374.5" "366.6" "359.5" "398.4" "294.6" "" "" "" "" "" "" "" "" "" "" "203.1" "216.3" "211.5" "175.0" "232.7" "208.3" "215.8" "196.2" "223.5" "294.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2203431477329866008" "False" "High" "IsMasterProtein" "Q9BZK3" "Putative nascent polypeptide-associated complex subunit alpha-like protein OS=Homo sapiens OX=9606 GN=NACA4P PE=5 SV=1" "0.000" "False" "7.343" "7" "1" "2" "1" "213" "23.3" "4.59" "7.19" "1" "other biological processes" "translational apparatus;other cell component" "other molecular function" "Pf01849" "" "" "NACA4P" "Q9BZK3" "" "" "0" "0" "1.108" "1.103" "0.951" "0.999" "0.872" "1.074" "0.984" "0.922" "0.579" "71.4" "79.2" "78.8" "67.9" "71.4" "62.3" "76.8" "70.3" "65.9" "41.3" "" "" "" "" "" "" "" "" "" "" "37.8" "43.9" "45.1" "31.3" "38.6" "34.6" "45.2" "38.4" "37.0" "41.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5259121706082363690" "False" "High" "IsMasterProtein" "Q6NS38" "DNA oxidative demethylase ALKBH2 OS=Homo sapiens OX=9606 GN=ALKBH2 PE=1 SV=1" "0.000" "False" "7.335" "4" "1" "1" "1" "261" "29.3" "9.66" "3.61" "1" "DNA metabolism;other metabolic processes;stress response" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13532" "121642" "ENSG00000189046" "ALKBH2" "A4PET2; hsa:121642; Q5XLE3; Q6NS38" "Direct reversal repair" "ALKBH2 mediated reversal of alkylation damage" "2" "0" "0.670" "0.796" "0.788" "0.859" "0.931" "0.958" "0.773" "0.856" "1.122" "121.3" "81.4" "96.5" "95.6" "104.3" "112.9" "116.3" "93.8" "103.9" "136.2" "" "" "" "" "" "" "" "" "" "" "64.3" "45.1" "55.3" "44.0" "56.4" "62.8" "68.4" "51.2" "58.3" "136.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8804712893716096184" "False" "High" "IsMasterProtein" "Q96S66" "Chloride channel CLIC-like protein 1 OS=Homo sapiens OX=9606 GN=CLCC1 PE=1 SV=1" "0.000" "False" "7.335" "2" "1" "2" "1" "551" "62.0" "5.55" "5.71" "1" "transport" "other membranes;ER/Golgi;nucleus;other cell component" "transporter activity" "Pf05934" "23155" "ENSG00000121940" "CLCC1" "hsa:23155; O94861; Q8WYP8; Q8WYP9; Q96S66; Q9BU25" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8619075754329803082" "False" "High" "IsMasterProtein" "P17275" "Transcription factor JunB OS=Homo sapiens OX=9606 GN=JUNB PE=1 SV=1" "0.000" "False" "7.331" "7" "3" "3" "2" "347" "35.9" "9.22" "8.27" "3" "cell cycle OR cell proliferation;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf03957" "3726" "ENSG00000171223" "JUNB" "hsa:3726; P17275; Q96GH3" "Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; Nuclear receptors meta-pathway; Kit receptor signaling pathway; Photodynamic therapy-induced AP-1 survival signaling; IL6 signaling pathway; TGF-beta signaling pathway; Oxidative stress response; Host-pathogen interaction of human coronaviruses - MAPK signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Orexin receptor pathway; Osteoarthritic chondrocyte hypertrophy" "NGF-stimulated transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Interleukin-4 and Interleukin-13 signaling; Nuclear events stimulated by ALK signaling in cancer" "18" "0" "0.962" "0.966" "1.206" "1.006" "0.971" "1.098" "0.975" "1.109" "0.763" "215.4" "207.3" "208.1" "259.9" "216.8" "209.2" "236.6" "210.0" "238.8" "164.3" "" "" "" "" "" "" "" "" "" "" "114.1" "114.9" "119.2" "119.7" "117.3" "116.4" "139.2" "114.6" "134.0" "164.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1450891647387080638" "False" "High" "IsMasterProtein" "Q9BUL8" "Programmed cell death protein 10 OS=Homo sapiens OX=9606 GN=PDCD10 PE=1 SV=1" "0.000" "False" "7.326" "9" "2" "4" "2" "212" "24.7" "8.19" "11.72" "2" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf06840, Pf20929" "11235" "ENSG00000114209" "PDCD10" "A8K515; D3DNN5; hsa:11235; O14811; Q9BUL8" "" "" "0" "0" "1.235" "1.122" "1.198" "1.134" "1.276" "1.180" "1.091" "1.082" "1.068" "234.8" "289.9" "263.3" "281.2" "266.2" "299.6" "277.0" "256.0" "254.1" "250.7" "" "" "" "" "" "" "" "" "" "" "124.3" "160.7" "150.8" "129.5" "144.0" "166.6" "163.0" "139.8" "142.5" "250.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1058846499056220573" "False" "High" "IsMasterProtein" "Q96CP2" "FLYWCH family member 2 OS=Homo sapiens OX=9606 GN=FLYWCH2 PE=1 SV=1" "0.000" "False" "7.324" "14" "2" "2" "2" "140" "14.6" "8.46" "6.24" "2" "" "" "" "Pf15423" "114984" "ENSG00000162076" "FLYWCH2" "hsa:114984; Q96CP2" "" "" "0" "0" "1.096" "1.194" "1.136" "1.006" "1.004" "1.051" "1.237" "1.151" "0.805" "139.9" "153.4" "167.1" "158.9" "140.7" "140.4" "147.1" "173.0" "161.0" "112.5" "" "" "" "" "" "" "" "" "" "" "74.1" "85.0" "95.7" "73.2" "76.1" "78.1" "86.6" "94.5" "90.3" "112.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6548420804533655280" "False" "High" "IsMasterProtein" "O43353" "Receptor-interacting serine/threonine-protein kinase 2 OS=Homo sapiens OX=9606 GN=RIPK2 PE=1 SV=2" "0.000" "False" "7.324" "6" "2" "2" "2" "540" "61.2" "7.09" "3.66" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00619, Pf07714" "8767" "ENSG00000104312" "RIPK2" "B7Z748; hsa:8767; O43353; Q6UWF0" "Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; T-cell receptor signaling pathway" "Downstream TCR signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; p75NTR recruits signalling complexes; TAK1-dependent IKK and NF-kappa-B activation ; activated TAK1 mediates p38 MAPK activation; Ovarian tumor domain proteases" "13" "0" "1.235" "1.227" "1.037" "1.354" "1.281" "1.278" "1.066" "1.218" "0.902" "122.0" "150.7" "149.6" "126.5" "165.2" "156.3" "155.9" "130.0" "148.6" "110.0" "" "" "" "" "" "" "" "" "" "" "64.6" "83.5" "85.7" "58.2" "89.4" "86.9" "91.7" "71.0" "83.3" "110.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2205363031532401399" "False" "High" "IsMasterProtein" "Q16763" "Ubiquitin-conjugating enzyme E2 S OS=Homo sapiens OX=9606 GN=UBE2S PE=1 SV=2" "0.000" "False" "7.323" "8" "1" "1" "1" "222" "23.8" "8.38" "4.25" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00179" "27338" "ENSG00000108106" "UBE2S" "hsa:27338; Q16763; Q9BTC1" "" "Antigen processing: Ubiquitination & Proteasome degradation; Senescence-Associated Secretory Phenotype (SASP); APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "19" "0" "1.268" "0.999" "1.298" "1.006" "1.140" "1.089" "1.065" "1.188" "1.332" "36.9" "46.8" "36.9" "47.9" "37.1" "42.1" "40.2" "39.3" "43.9" "49.2" "" "" "" "" "" "" "" "" "" "" "19.6" "26.0" "21.1" "22.1" "20.1" "23.4" "23.7" "21.5" "24.6" "49.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8090563644210438212" "False" "High" "IsMasterProtein" "Q6V1X1" "Dipeptidyl peptidase 8 OS=Homo sapiens OX=9606 GN=DPP8 PE=1 SV=1" "0.000" "False" "7.306" "4" "4" "4" "4" "898" "103.3" "5.80" "7.15" "4" "protein metabolism;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00326, Pf00930, Pf19520" "54878" "ENSG00000074603" "DPP8" "hsa:54878; Q6V1X1; Q7Z4C8; Q7Z4D3; Q7Z4E1; Q8IWG7; Q8NEM5; Q96JX1; Q9HBM2; Q9HBM3; Q9HBM4; Q9HBM5; Q9NXF4" "" "" "0" "0" "1.203" "0.890" "1.634" "1.161" "0.904" "1.414" "1.079" "0.973" "0.670" "198.3" "238.5" "176.4" "323.9" "230.1" "179.2" "280.4" "214.0" "193.0" "132.9" "" "" "" "" "" "" "" "" "" "" "105.0" "132.2" "101.0" "149.2" "124.5" "99.7" "165.0" "116.8" "108.3" "132.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3114366665604462397" "False" "High" "IsMasterProtein" "Q9BZE2" "tRNA pseudouridine(38/39) synthase OS=Homo sapiens OX=9606 GN=PUS3 PE=1 SV=3" "0.000" "False" "7.302" "5" "3" "3" "3" "481" "55.6" "7.49" "4.97" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01416" "83480" "ENSG00000110060" "PUS3" "B2RAM0; hsa:83480; Q96D17; Q96J23; Q96NB4; Q9BZE2" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.053" "1.092" "1.022" "1.081" "1.142" "0.963" "0.971" "1.031" "0.776" "245.4" "258.3" "267.9" "250.9" "265.2" "280.4" "236.3" "238.2" "253.2" "190.4" "" "" "" "" "" "" "" "" "" "" "130.0" "143.2" "153.4" "115.5" "143.5" "156.0" "139.1" "130.0" "142.0" "190.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7212172965787635527" "False" "High" "IsMasterProtein" "Q15031" "Leucine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=LARS2 PE=1 SV=2" "0.000" "False" "7.300" "3" "3" "3" "3" "903" "101.9" "8.22" "7.15" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00133, Pf08264, Pf13603" "23395" "ENSG00000011376" "LARS2" "hsa:23395; Q15031" "Amino acid metabolism; IL-18 signaling pathway; Primary ovarian insufficiency" "Mitochondrial tRNA aminoacylation" "4" "0" "0.988" "1.046" "1.059" "1.052" "1.214" "1.108" "0.797" "1.173" "4.476" "133.1" "131.5" "139.2" "141.0" "139.9" "161.5" "147.4" "106.0" "156.1" "595.6" "" "" "" "" "" "" "" "" "" "" "70.5" "72.9" "79.7" "64.9" "75.7" "89.9" "86.8" "57.9" "87.6" "595.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8700335326144916466" "False" "High" "IsMasterProtein" "Q9UET6" "tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase OS=Homo sapiens OX=9606 GN=FTSJ1 PE=1 SV=2" "0.000" "False" "7.294" "7" "2" "2" "2" "329" "36.1" "5.69" "2.63" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01728" "24140" "ENSG00000068438" "FTSJ1" "B2RCJ0; hsa:24140; O75670; Q9UET6" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.900" "0.894" "0.955" "0.970" "0.955" "0.917" "0.900" "0.952" "1.061" "170.1" "153.0" "152.1" "162.4" "165.0" "162.4" "156.0" "153.0" "162.0" "180.5" "" "" "" "" "" "" "" "" "" "" "90.1" "84.8" "87.1" "74.8" "89.3" "90.3" "91.8" "83.5" "90.9" "180.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4028624148225623875" "False" "High" "IsMasterProtein" "Q9NXE8" "Pre-mRNA-splicing factor CWC25 homolog OS=Homo sapiens OX=9606 GN=CWC25 PE=1 SV=1" "0.000" "False" "7.288" "6" "3" "3" "3" "425" "49.6" "10.18" "6.55" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf10197, Pf12542" "54883" "ENSG00000273559; ENSG00000276761" "CWC25" "A0JLM3; hsa:54883; Q68DK5; Q9NXE8" "17q12 copy number variation syndrome" "mRNA Splicing - Major Pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8566707279340017586" "False" "High" "IsMasterProtein" "Q9Y6M7" "Sodium bicarbonate cotransporter 3 OS=Homo sapiens OX=9606 GN=SLC4A7 PE=1 SV=2" "0.000" "False" "7.282" "2" "3" "5" "3" "1214" "136.0" "6.71" "9.03" "3" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf00955, Pf07565" "9497" "ENSG00000033867" "SLC4A7" "A6NIA8; B2CI53; B5M449; B5M451; B5M452; B5M453; B6DY52; B6DY53; C9JST9; D3K174; D3K175; hsa:9497; O60350; Q6AHZ9; Q9HC88; Q9UIB9; Q9Y6M7" "IL-18 signaling pathway" "RHOQ GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; RHOH GTPase cycle; Bicarbonate transporters" "7" "0" "1.001" "1.045" "1.068" "0.971" "1.099" "0.982" "1.301" "0.967" "0.678" "118.6" "118.7" "124.0" "126.6" "115.1" "130.3" "116.4" "154.3" "114.7" "80.5" "" "" "" "" "" "" "" "" "" "" "62.8" "65.8" "71.0" "58.3" "62.3" "72.5" "68.5" "84.2" "64.3" "80.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6036677964263745223" "False" "High" "IsMasterProtein" "Q8NFH4" "Nucleoporin Nup37 OS=Homo sapiens OX=9606 GN=NUP37 PE=1 SV=1" "0.000" "False" "7.281" "5" "2" "2" "2" "326" "36.7" "5.92" "6.49" "2" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00400" "79023" "ENSG00000075188" "NUP37" "hsa:79023; Q8NFH4; Q9H644" "" "Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Vpr-mediated nuclear import of PICs; Transport of Mature mRNA derived from an Intron-Containing Transcript; tRNA processing in the nucleus; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "35" "0" "0.982" "0.998" "0.849" "0.954" "1.143" "1.010" "0.918" "1.021" "0.859" "546.5" "536.4" "545.1" "463.9" "521.1" "624.5" "552.0" "501.7" "557.7" "469.5" "" "" "" "" "" "" "" "" "" "" "289.3" "297.4" "312.2" "213.7" "281.9" "347.4" "324.9" "273.9" "312.8" "469.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1831448905794715132" "False" "High" "IsMasterProtein" "P84098" "Large ribosomal subunit protein eL19 OS=Homo sapiens OX=9606 GN=RPL19 PE=1 SV=1" "0.000" "False" "7.270" "15" "3" "5" "3" "196" "23.5" "11.47" "5.08" "3" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01280" "6143" "ENSG00000108298" "RPL19" "B2R4K2; P14118; P22908; P84098; Q502Y6; Q7Z6E4" "Cytoplasmic ribosomal proteins" "SRP-dependent cotranslational protein targeting to membrane; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.015" "1.028" "1.042" "1.065" "1.098" "1.204" "1.002" "1.170" "1.946" "249.2" "252.9" "256.2" "259.8" "265.4" "273.6" "300.0" "249.6" "291.7" "485.0" "" "" "" "" "" "" "" "" "" "" "132.0" "140.2" "146.7" "119.6" "143.6" "152.2" "176.6" "136.3" "163.6" "485.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2668424523932492370" "False" "High" "IsMasterProtein" "Q9BVQ7" "ATPase family gene 2 protein homolog B OS=Homo sapiens OX=9606 GN=AFG2B PE=1 SV=2" "0.000" "False" "7.266" "5" "3" "4" "3" "753" "80.7" "8.09" "8.60" "3" "other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00004, Pf17862" "79029" "ENSG00000171763" "AFG2B" "C9JHR5; hsa:79029; Q9BVQ7; Q9H8W7; Q9HA41" "" "" "0" "0" "1.275" "0.951" "1.278" "1.078" "1.113" "1.163" "0.896" "0.970" "0.722" "97.1" "123.9" "92.4" "124.1" "104.7" "108.2" "113.0" "87.1" "94.2" "70.1" "" "" "" "" "" "" "" "" "" "" "51.4" "68.7" "52.9" "57.2" "56.7" "60.2" "66.5" "47.5" "52.9" "70.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3538184499835993456" "False" "High" "IsMasterProtein" "P43897" "Elongation factor Ts, mitochondrial OS=Homo sapiens OX=9606 GN=TSFM PE=1 SV=2" "0.000" "False" "7.256" "5" "2" "2" "2" "325" "35.4" "8.38" "6.32" "2" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity" "Pf00889" "10102" "ENSG00000123297" "TSFM" "B4E391; F5H2T7; hsa:10102; P43897; Q561V7; Q8TBC2; Q9UQK0" "" "Mitochondrial translation elongation" "1" "0" "1.007" "1.047" "1.379" "1.187" "1.201" "1.048" "0.162" "0.990" "15.961" "102.1" "102.8" "106.9" "140.7" "121.1" "122.5" "107.0" "16.5" "101.1" "1628.8" "" "" "" "" "" "" "" "" "" "" "54.0" "57.0" "61.2" "64.8" "65.5" "68.2" "63.0" "9.0" "56.7" "1628.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5853605967738796226" "False" "High" "IsMasterProtein" "Q13137" "Calcium-binding and coiled-coil domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CALCOCO2 PE=1 SV=1" "0.000" "False" "7.237" "5" "3" "3" "3" "446" "52.2" "5.02" "8.96" "3" "other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf17751" "10241" "ENSG00000136436" "CALCOCO2" "B2RBT0; B4DDC4; B4DDT4; B4DP36; B4E0C0; E7ENK0; E7ETP5; E9PBE5; hsa:10241; Q13137; Q53FQ5; Q53HB5; Q6IBN9; Q9BTF7" "" "" "0" "0" "1.045" "1.005" "0.977" "0.906" "0.871" "0.928" "0.807" "0.796" "0.996" "157.5" "164.7" "158.3" "154.0" "142.7" "137.2" "146.2" "127.1" "125.5" "157.0" "" "" "" "" "" "" "" "" "" "" "83.4" "91.3" "90.7" "70.9" "77.2" "76.3" "86.0" "69.4" "70.4" "157.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8387303708123169852" "False" "High" "IsMasterProtein" "P07602" "Prosaposin OS=Homo sapiens OX=9606 GN=PSAP PE=1 SV=2" "0.000" "False" "7.234" "4" "2" "2" "2" "524" "58.1" "5.17" "5.51" "2" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf02199, Pf03489, Pf05184" "5660" "ENSG00000197746" "PSAP" "hsa:5660; P07292; P07602; P15793; P78538; P78541; P78546; P78547; P78558; Q53Y86; Q6IBQ6; Q92739; Q92740; Q92741; Q92742" "Degradation pathway of sphingolipids, including diseases" "Neutrophil degranulation; G alpha (i) signalling events; Platelet degranulation ; Peptide ligand-binding receptors; Glycosphingolipid catabolism" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5843152145544884275" "False" "High" "IsMasterProtein" "Q6KC79" "Nipped-B-like protein OS=Homo sapiens OX=9606 GN=NIPBL PE=1 SV=2" "0.000" "False" "7.232" "1" "3" "3" "3" "2804" "315.9" "7.91" "7.77" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12765, Pf12830" "25836" "ENSG00000164190" "NIPBL" "hsa:25836; Q6KC79; Q6KCD6; Q6N080; Q6ZT92; Q7Z2E6; Q8N4M5; Q9Y6Y3; Q9Y6Y4" "Cohesin complex - Cornelia de Lange syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome" "Cohesin Loading onto Chromatin" "3" "0" "0.862" "0.968" "1.026" "0.992" "0.983" "1.535" "1.669" "1.648" "0.797" "215.7" "186.0" "208.7" "221.3" "214.0" "212.0" "331.2" "360.1" "355.4" "171.9" "" "" "" "" "" "" "" "" "" "" "114.2" "103.1" "119.5" "101.9" "115.8" "117.9" "194.9" "196.6" "199.4" "171.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-319216844392798796" "False" "High" "IsMasterProtein" "Q9Y4R8" "Telomere length regulation protein TEL2 homolog OS=Homo sapiens OX=9606 GN=TELO2 PE=1 SV=2" "0.000" "False" "7.229" "3" "3" "3" "3" "837" "91.7" "5.76" "7.93" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10193" "9894" "ENSG00000100726" "TELO2" "D3DU73; hsa:9894; O75168; Q7LDV4; Q9BR21; Q9Y4R8" "Fragile X syndrome; Pleural mesothelioma" "" "2" "0" "1.018" "0.976" "1.106" "1.032" "1.089" "1.039" "0.541" "0.897" "4.460" "47.0" "47.8" "45.8" "52.0" "48.5" "51.2" "48.8" "25.4" "42.1" "209.5" "" "" "" "" "" "" "" "" "" "" "24.9" "26.5" "26.3" "23.9" "26.2" "28.5" "28.7" "13.9" "23.6" "209.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7220611050320335909" "False" "High" "IsMasterProtein" "Q8TDH9" "Biogenesis of lysosome-related organelles complex 1 subunit 5 OS=Homo sapiens OX=9606 GN=BLOC1S5 PE=1 SV=1" "0.000" "False" "7.225" "9" "2" "2" "2" "187" "21.6" "7.59" "6.58" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "ER/Golgi;other cell component" "" "Pf14942" "63915" "ENSG00000188428" "BLOC1S5" "B4DVM2; hsa:63915; Q0VDJ6; Q0VDJ7; Q5THS1; Q68D56; Q8N5F9; Q8TDH9; Q9NU16" "" "" "0" "0" "1.139" "1.199" "1.092" "1.124" "1.126" "1.025" "1.153" "1.238" "0.755" "289.2" "329.4" "346.8" "315.9" "325.1" "325.7" "296.4" "333.4" "357.9" "218.3" "" "" "" "" "" "" "" "" "" "" "153.1" "182.6" "198.6" "145.5" "175.9" "181.2" "174.5" "182.0" "200.8" "218.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8837747805973553035" "False" "High" "IsMasterProtein" "Q12778" "Forkhead box protein O1 OS=Homo sapiens OX=9606 GN=FOXO1 PE=1 SV=2" "0.000" "False" "7.220" "2" "1" "1" "1" "655" "69.6" "6.77" "3.60" "1" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250, Pf16675, Pf16676" "2308" "ENSG00000150907" "FOXO1" "hsa:2308; O43523; Q12778; Q5VYC7; Q6NSK6" "Androgen receptor signaling pathway; Energy metabolism; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; AGE/RAGE pathway; Adipogenesis; Constitutive androstane receptor pathway; Pregnane X receptor pathway; Vitamin D receptor pathway; Nuclear receptors meta-pathway; Copper homeostasis; Melatonin metabolism and effects; RAC1/PAK1/p38/MMP2 pathway; Transcription factor regulation in adipogenesis; NAD metabolism, sirtuins and aging; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; White fat cell differentiation; Somatroph axis (GH) and its relationship to dietary restriction and aging; EGF/EGFR signaling pathway; Leukocyte-intrinsic Hippo pathway functions; Gastrin signaling pathway; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; Kynurenine pathway and links to cell senescence; FOXA2 pathway; Pleural mesothelioma; Interactions of natural killer cells in pancreatic cancer; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Warburg effect modulated by deubiquitinating enzymes and their substrates; Extrafollicular and follicular B cell activation by SARS-CoV-2; Primary ovarian insufficiency; Rubinstein-Taybi syndrome 1; ErbB signaling pathway" "MAPK6/MAPK4 signaling; Regulation of localization of FOXO transcription factors; AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Interleukin-4 and Interleukin-13 signaling; FOXO-mediated transcription of cell cycle genes; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; AKT-mediated inactivation of FOXO1A" "52" "0" "1.197" "0.988" "1.522" "1.265" "1.246" "1.581" "1.312" "1.492" "3.585" "41.5" "49.7" "41.0" "63.2" "52.6" "51.8" "65.7" "54.5" "62.0" "148.9" "" "" "" "" "" "" "" "" "" "" "22.0" "27.6" "23.5" "29.1" "28.4" "28.8" "38.7" "29.8" "34.8" "148.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3387602003086690885" "False" "High" "IsMasterProtein" "Q9BVC5" "Ashwin OS=Homo sapiens OX=9606 GN=C2orf49 PE=1 SV=1" "0.000" "False" "7.211" "7" "2" "2" "2" "232" "25.8" "9.74" "5.50" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus;other cell component" "" "Pf15323" "79074" "ENSG00000135974" "C2orf49" "B3KXN3; B4E2G9; hsa:79074; Q9BVC5" "" "tRNA processing in the nucleus" "1" "0" "0.794" "0.796" "0.874" "0.899" "0.987" "1.259" "1.210" "1.200" "1.635" "86.2" "68.5" "68.6" "75.3" "77.5" "85.1" "108.5" "104.3" "103.5" "140.9" "" "" "" "" "" "" "" "" "" "" "45.6" "38.0" "39.3" "34.7" "41.9" "47.3" "63.9" "56.9" "58.0" "140.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "407060077554528043" "False" "High" "IsMasterProtein" "Q5T3I0" "G patch domain-containing protein 4 OS=Homo sapiens OX=9606 GN=GPATCH4 PE=1 SV=2" "0.000" "False" "7.211" "7" "3" "3" "3" "446" "50.4" "9.63" "3.60" "3" "" "nucleus" "" "Pf01585" "" "ENSG00000292251" "GPATCH4" "Q5T3I0; Q5T3I1; Q6ZUE7; Q8IWG8; Q9NXH4" "" "" "0" "0" "0.991" "0.999" "1.283" "1.123" "1.100" "2.154" "2.016" "2.108" "1.211" "118.0" "116.9" "117.9" "151.3" "132.5" "129.8" "254.2" "237.9" "248.8" "143.0" "" "" "" "" "" "" "" "" "" "" "62.5" "64.8" "67.5" "69.7" "71.7" "72.2" "149.6" "129.9" "139.6" "143.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "854871700707894946" "False" "High" "IsMasterProtein" "Q9NZL4" "Hsp70-binding protein 1 OS=Homo sapiens OX=9606 GN=HSPBP1 PE=1 SV=2" "0.000" "False" "7.192" "6" "2" "2" "2" "359" "39.3" "5.21" "4.17" "2" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf08609" "23640" "ENSG00000133265" "HSPBP1" "B3KQP0; B4DG11; hsa:23640; O95351; Q6ZNU5; Q9NZL4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4704340040215325088" "False" "High" "IsMasterProtein" "Q9GZN8" "Adipose-secreted signaling protein OS=Homo sapiens OX=9606 GN=ADISSP PE=1 SV=3" "0.000" "False" "7.192" "9" "1" "1" "1" "174" "19.3" "6.84" "3.01" "1" "other metabolic processes;other biological processes" "non-structural extracellular" "other molecular function" "Pf15006" "54976" "ENSG00000101220" "ADISSP" "A8K4J0; D3DVX8; hsa:54976; Q5JX81; Q9GZN8; Q9NWX3" "" "" "0" "0" "1.290" "0.935" "1.700" "1.095" "1.168" "0.957" "1.015" "1.319" "0.677" "21.7" "28.0" "20.3" "36.9" "23.8" "25.3" "20.8" "22.0" "28.6" "14.7" "" "" "" "" "" "" "" "" "" "" "11.5" "15.5" "11.6" "17.0" "12.9" "14.1" "12.2" "12.0" "16.0" "14.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5634495844004760" "False" "High" "IsMasterProtein" "O60907" "F-box-like/WD repeat-containing protein TBL1X OS=Homo sapiens OX=9606 GN=TBL1X PE=1 SV=3" "0.000" "False" "7.185" "6" "3" "4" "1" "577" "62.5" "6.55" "7.35" "3" "protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf08513" "6907" "ENSG00000101849" "TBL1X" "A8K044; A8K4J7; hsa:6907; O60907; Q86UY2" "Ectoderm differentiation; Ectoderm differentiation; Rett syndrome" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression" "22" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4723246947420564514" "False" "High" "IsMasterProtein" "O94915" "Protein furry homolog-like OS=Homo sapiens OX=9606 GN=FRYL PE=1 SV=2" "0.000" "False" "7.180" "1" "3" "3" "3" "3013" "339.4" "5.58" "5.25" "3" "cell organization and biogenesis;developmental processes;other biological processes" "other cell component" "" "Pf14222, Pf14225, Pf14228, Pf19421" "285527" "ENSG00000075539" "FRYL" "hsa:285527; O94915; O95640; Q8WTZ5; Q9NT40" "" "" "0" "0" "1.103" "1.002" "1.126" "1.062" "1.085" "1.126" "1.023" "1.099" "1.156" "135.9" "149.8" "136.1" "152.9" "144.3" "147.4" "153.0" "139.0" "149.3" "157.1" "" "" "" "" "" "" "" "" "" "" "71.9" "83.1" "77.9" "70.4" "78.1" "82.0" "90.0" "75.9" "83.8" "157.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5030873736405490960" "False" "High" "IsMasterProtein" "Q92686" "Neurogranin OS=Homo sapiens OX=9606 GN=NRGN PE=1 SV=1" "0.000" "False" "7.179" "31" "2" "4" "2" "78" "7.6" "7.87" "11.53" "2" "developmental processes;signal transduction" "cytosol" "other molecular function" "Pf00612" "4900" "ENSG00000154146" "NRGN" "hsa:4900; Q92686" "" "Long-term potentiation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6653368877228174187" "False" "High" "IsMasterProtein" "Q9NRX2" "Large ribosomal subunit protein bL17m OS=Homo sapiens OX=9606 GN=MRPL17 PE=1 SV=1" "0.000" "False" "7.157" "13" "3" "3" "3" "175" "20.0" "10.11" "6.92" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01196" "63875" "ENSG00000158042" "MRPL17" "D3DQU3; hsa:63875; Q6IAH8; Q96Q53; Q9C066; Q9NRX2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6297313033402222307" "False" "High" "IsMasterProtein" "Q8TF01" "Arginine/serine-rich protein PNISR OS=Homo sapiens OX=9606 GN=PNISR PE=1 SV=2" "0.000" "False" "7.139" "1" "1" "1" "1" "805" "92.5" "10.02" "3.91" "1" "" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf15996" "25957" "ENSG00000132424" "PNISR" "A8K540; E1P5D2; hsa:25957; Q5T064; Q5T065; Q6P2B4; Q6P2N4; Q6PJ93; Q6PK36; Q7Z640; Q8N2L1; Q8TF00; Q8TF01; Q96K10; Q96SI3; Q96SM5; Q9P076; Q9P0C0; Q9Y4N3" "" "" "0" "0" "0.877" "1.130" "1.036" "0.992" "1.020" "0.955" "1.129" "1.206" "0.402" "92.9" "81.5" "105.0" "96.3" "92.2" "94.8" "88.8" "104.9" "112.0" "37.4" "" "" "" "" "" "" "" "" "" "" "49.2" "45.2" "60.1" "44.3" "49.9" "52.7" "52.2" "57.3" "62.9" "37.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9128432651374987381" "False" "High" "IsMasterProtein" "Q9NNW5" "tRNA (34-2'-O)-methyltransferase regulator WDR6 OS=Homo sapiens OX=9606 GN=WDR6 PE=1 SV=1" "0.000" "False" "7.137" "2" "2" "3" "2" "1121" "121.6" "6.87" "8.38" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;nucleic acid binding activity" "Pf00400" "11180" "ENSG00000178252" "WDR6" "B4DHK2; hsa:11180; Q3MIT1; Q9NNW5; Q9UF63" "" "RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle" "5" "0" "1.285" "1.011" "1.290" "1.132" "1.020" "1.094" "0.813" "0.989" "1.609" "35.1" "45.1" "35.5" "45.3" "39.8" "35.8" "38.4" "28.5" "34.7" "56.5" "" "" "" "" "" "" "" "" "" "" "18.6" "25.0" "20.3" "20.9" "21.5" "19.9" "22.6" "15.6" "19.5" "56.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8041398226355410347" "False" "High" "IsMasterProtein" "Q9NUL5" "Shiftless antiviral inhibitor of ribosomal frameshifting protein OS=Homo sapiens OX=9606 GN=SHFL PE=1 SV=2" "0.000" "False" "7.130" "7" "2" "2" "2" "291" "33.1" "7.25" "5.27" "2" "stress response;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf15135" "55337" "ENSG00000130813" "SHFL" "A8MQT9; hsa:55337; Q4G188; Q8IYH6; Q8N8V1; Q9NUL5" "" "" "0" "0" "1.162" "1.115" "1.116" "1.013" "0.910" "0.900" "0.998" "0.846" "0.631" "149.1" "173.3" "166.2" "166.4" "151.1" "135.7" "134.3" "148.7" "126.2" "94.0" "" "" "" "" "" "" "" "" "" "" "79.0" "96.1" "95.2" "76.6" "81.8" "75.5" "79.0" "81.2" "70.8" "94.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7173448255119182363" "False" "High" "IsMasterProtein" "P27635" "Large ribosomal subunit protein uL16 OS=Homo sapiens OX=9606 GN=RPL10 PE=1 SV=5" "0.000" "False" "7.129" "10" "2" "4" "2" "214" "24.6" "10.08" "10.30" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00252" "6134" "ENSG00000147403" "RPL10" "A3KQT0; D3DWW6; hsa:6134; P27635; Q16470; Q2HXT7; Q53FH7; Q6FGN8; Q8TDA5" "Cytoplasmic ribosomal proteins; Primary ovarian insufficiency" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination" "15" "0" "1.108" "1.031" "1.153" "1.164" "1.154" "1.065" "0.891" "0.983" "0.873" "228.6" "253.2" "235.6" "263.4" "266.1" "263.7" "243.5" "203.8" "224.7" "199.5" "" "" "" "" "" "" "" "" "" "" "121.0" "140.4" "134.9" "121.3" "144.0" "146.7" "143.3" "111.2" "126.0" "199.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1701299476432316153" "False" "High" "IsMasterProtein" "Q9BU61" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 OS=Homo sapiens OX=9606 GN=NDUFAF3 PE=1 SV=1" "0.000" "False" "7.123" "18" "2" "2" "2" "184" "20.3" "8.22" "3.97" "2" "cell organization and biogenesis" "other membranes;mitochondrion;nucleus" "" "Pf04430" "25915" "ENSG00000178057" "NDUFAF3" "hsa:25915; Q9BU61" "" "Complex I biogenesis" "1" "0" "1.077" "0.950" "0.991" "1.104" "1.034" "0.929" "0.949" "1.021" "0.793" "100.7" "108.5" "95.7" "99.8" "111.2" "104.1" "93.6" "95.6" "102.9" "79.9" "" "" "" "" "" "" "" "" "" "" "53.3" "60.1" "54.8" "46.0" "60.2" "57.9" "55.1" "52.2" "57.7" "79.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4404494894943398685" "False" "High" "IsMasterProtein" "Q6P5R6" "Ribosomal protein eL22-like OS=Homo sapiens OX=9606 GN=RPL22L1 PE=1 SV=2" "0.000" "False" "7.118" "10" "1" "2" "1" "122" "14.6" "9.38" "8.49" "1" "protein metabolism;other metabolic processes" "translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01776" "200916" "ENSG00000163584" "RPL22L1" "hsa:200916; Q32Q77; Q6P5R6" "" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "13" "0" "1.044" "1.048" "1.110" "0.978" "1.032" "1.000" "1.001" "1.051" "1.215" "208.9" "218.1" "219.0" "231.9" "204.2" "215.6" "208.8" "209.2" "219.5" "253.8" "" "" "" "" "" "" "" "" "" "" "110.6" "120.9" "125.4" "106.8" "110.5" "119.9" "122.9" "114.2" "123.1" "253.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7908079185192483938" "False" "High" "IsMasterProtein" "P49716" "CCAAT/enhancer-binding protein delta OS=Homo sapiens OX=9606 GN=CEBPD PE=1 SV=2" "0.000" "False" "7.116" "7" "2" "3" "2" "269" "28.4" "8.28" "8.49" "2" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07716" "1052" "ENSG00000221869" "CEBPD" "hsa:1052; P49716; Q14937; Q2M2X9" "IL-17 signaling pathway; Adipogenesis; MECP2 and associated Rett syndrome; Transcription factor regulation in adipogenesis; White fat cell differentiation; Transcriptional cascade regulating adipogenesis; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "HCMV Late Events; Transcriptional regulation of white adipocyte differentiation; Interleukin-4 and Interleukin-13 signaling" "11" "0" "0.983" "1.197" "1.191" "1.060" "1.049" "1.257" "1.274" "1.413" "1.335" "298.4" "293.3" "357.2" "355.5" "316.3" "312.9" "375.2" "380.2" "421.7" "398.4" "" "" "" "" "" "" "" "" "" "" "158.0" "162.6" "204.6" "163.7" "171.1" "174.1" "220.8" "207.5" "236.5" "398.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1614464300928510251" "False" "High" "IsMasterProtein" "P55854" "Small ubiquitin-related modifier 3 OS=Homo sapiens OX=9606 GN=SUMO3 PE=1 SV=2" "0.000" "False" "7.104" "20" "2" "5" "1" "103" "11.6" "5.49" "16.50" "2" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11976" "6612" "ENSG00000184900" "SUMO3" "B2R5X4; B4DUW4; hsa:6612; P55854; Q53HI9; Q6FGD4; Q9BWR4" "Exercise-induced circadian regulation" "SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER; SUMOylation of immune response proteins; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1788576308263676540" "False" "High" "IsMasterProtein" "Q9BUK6" "Protein misato homolog 1 OS=Homo sapiens OX=9606 GN=MSTO1 PE=1 SV=1" "0.000" "False" "7.104" "4" "2" "2" "2" "570" "61.8" "6.11" "5.49" "2" "cell organization and biogenesis" "other membranes;cytosol;mitochondrion;other cell component" "" "Pf10644, Pf14881" "55154" "ENSG00000125459" "MSTO1" "hsa:55154; Q53GR8; Q5CZ69; Q5T717; Q68CT6; Q7LBZ8; Q7Z3M7; Q7Z558; Q8TE05; Q9BUK6; Q9NQX2; Q9NVU4" "" "" "0" "0" "0.797" "0.829" "0.924" "1.044" "1.036" "0.946" "0.853" "0.711" "1.288" "38.5" "30.7" "31.9" "35.5" "40.1" "39.8" "36.4" "32.8" "27.3" "49.6" "" "" "" "" "" "" "" "" "" "" "20.4" "17.0" "18.3" "16.4" "21.7" "22.2" "21.4" "17.9" "15.3" "49.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6341568024441871550" "False" "High" "IsMasterProtein" "O75131" "Copine-3 OS=Homo sapiens OX=9606 GN=CPNE3 PE=1 SV=1" "0.000" "False" "7.092" "5" "3" "4" "3" "537" "60.1" "5.85" "9.68" "3" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00168, Pf07002" "8895" "ENSG00000085719" "CPNE3" "A8KA47; hsa:8895; O75131; Q8IYA1" "" "Neutrophil degranulation; Glycerophospholipid biosynthesis" "2" "0" "0.963" "0.914" "1.023" "1.079" "0.985" "1.121" "0.885" "1.080" "1.624" "307.8" "296.3" "281.3" "314.8" "332.1" "303.1" "345.0" "272.3" "332.5" "499.7" "" "" "" "" "" "" "" "" "" "" "163.0" "164.3" "161.1" "145.0" "179.7" "168.6" "203.0" "148.7" "186.5" "499.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3047103662304523242" "False" "High" "IsMasterProtein" "Q9ULD9" "Zinc finger protein 608 OS=Homo sapiens OX=9606 GN=ZNF608 PE=1 SV=4" "0.000" "False" "7.089" "2" "3" "4" "3" "1512" "162.1" "8.79" "9.62" "3" "other biological processes" "nucleus" "other molecular function" "" "57507" "ENSG00000168916" "ZNF608" "A7E2W9; hsa:57507; Q3SYM6; Q68D12; Q8IY05; Q9ULD9; Q9Y5A1" "" "" "0" "0" "1.049" "0.926" "1.351" "1.047" "0.998" "1.258" "1.262" "1.318" "1.368" "190.8" "200.2" "176.7" "257.7" "199.8" "190.4" "240.0" "240.7" "251.4" "261.0" "" "" "" "" "" "" "" "" "" "" "101.0" "111.0" "101.2" "118.7" "108.1" "105.9" "141.2" "131.4" "141.1" "261.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5094806735738830032" "False" "High" "IsMasterProtein" "O75151" "Lysine-specific demethylase PHF2 OS=Homo sapiens OX=9606 GN=PHF2 PE=1 SV=4" "0.000" "False" "7.086" "2" "2" "2" "2" "1096" "120.7" "9.17" "4.52" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00628, Pf02373, Pf17811" "5253" "ENSG00000197724" "PHF2" "hsa:5253; O75151; Q4VXG0; Q8N3K2; Q9Y6N4" "" "HDMs demethylate histones" "1" "0" "0.830" "0.713" "0.784" "1.197" "1.176" "1.588" "1.750" "2.404" "0.641" "44.3" "36.8" "31.6" "34.7" "53.0" "52.1" "70.3" "77.5" "106.5" "28.4" "" "" "" "" "" "" "" "" "" "" "23.5" "20.4" "18.1" "16.0" "28.7" "29.0" "41.4" "42.3" "59.7" "28.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "342990274906048664" "False" "High" "IsMasterProtein" "P48730" "Casein kinase I isoform delta OS=Homo sapiens OX=9606 GN=CSNK1D PE=1 SV=2" "0.000" "False" "7.074" "6" "2" "2" "2" "415" "47.3" "9.74" "5.49" "2" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1453" "ENSG00000141551" "CSNK1D" "A2I2P2; hsa:1453; P48730; Q96KZ6; Q9BTN5" "Melatonin metabolism and effects; Wnt signaling pathway; Hedgehog signaling pathway" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Circadian Clock; Major pathway of rRNA processing in the nucleolus and cytosol; COPII-mediated vesicle transport" "13" "0" "1.043" "1.177" "1.272" "1.160" "1.231" "1.153" "1.188" "1.241" "1.085" "95.1" "99.2" "112.0" "121.0" "110.3" "117.1" "109.6" "113.0" "118.0" "103.2" "" "" "" "" "" "" "" "" "" "" "50.4" "55.0" "64.1" "55.7" "59.7" "65.1" "64.5" "61.7" "66.2" "103.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5539226776075582677" "False" "High" "IsMasterProtein" "Q5TC82" "Roquin-1 OS=Homo sapiens OX=9606 GN=RC3H1 PE=1 SV=1" "0.000" "False" "7.070" "2" "2" "2" "2" "1133" "125.7" "7.27" "5.73" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf14634, Pf18386, Pf21206" "149041" "ENSG00000135870" "RC3H1" "B3KVK1; hsa:149041; Q5TC82; Q5W180; Q5W181; Q8IVE6; Q8N9V1" "" "" "0" "0" "1.089" "1.176" "1.219" "1.079" "1.046" "1.010" "1.061" "1.011" "0.794" "121.8" "132.6" "143.2" "148.5" "131.5" "127.4" "123.1" "129.2" "123.1" "96.7" "" "" "" "" "" "" "" "" "" "" "64.5" "73.5" "82.0" "68.4" "71.1" "70.9" "72.4" "70.5" "69.1" "96.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5233128446451314475" "False" "High" "IsMasterProtein" "Q8IVD9" "NudC domain-containing protein 3 OS=Homo sapiens OX=9606 GN=NUDCD3 PE=1 SV=3" "0.000" "False" "7.069" "2" "1" "2" "1" "361" "40.8" "5.25" "6.81" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf04969, Pf14050" "23386" "ENSG00000015676" "NUDCD3" "hsa:23386; Q8IVD9; Q9BTI3; Q9H7W9; Q9UPT4" "" "" "0" "0" "1.122" "1.206" "1.259" "1.401" "1.310" "2.471" "2.504" "3.116" "3.487" "269.3" "302.2" "324.8" "339.0" "377.3" "352.7" "665.4" "674.4" "839.3" "939.1" "" "" "" "" "" "" "" "" "" "" "142.6" "167.6" "186.0" "156.1" "204.1" "196.2" "391.6" "368.1" "470.8" "939.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-475093268658479309" "False" "High" "IsMasterProtein" "P61599" "N-alpha-acetyltransferase 20 OS=Homo sapiens OX=9606 GN=NAA20 PE=1 SV=1" "0.000" "False" "7.064" "11" "2" "2" "2" "178" "20.4" "5.03" "6.19" "2" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "51126" "ENSG00000173418" "NAA20" "A6NHA3; B2R4G4; hsa:51126; P61599; Q5TFT7; Q9D7H8; Q9H0Y4; Q9NQH6; Q9Y6D2" "Metapathway biotransformation Phase I and II" "" "1" "0" "0.962" "0.971" "1.038" "0.956" "1.208" "1.093" "1.006" "0.938" "0.688" "160.9" "154.8" "156.2" "167.1" "153.9" "194.5" "175.9" "161.9" "151.0" "110.8" "" "" "" "" "" "" "" "" "" "" "85.2" "85.8" "89.5" "77.0" "83.2" "108.2" "103.5" "88.4" "84.7" "110.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8192519440703409270" "False" "High" "IsMasterProtein" "Q8NB37" "Glutamine amidotransferase-like class 1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GATD1 PE=1 SV=1" "0.000" "False" "7.050" "10" "2" "2" "2" "220" "23.3" "6.61" "6.14" "2" "other metabolic processes" "other cell component" "other molecular function" "" "347862" "ENSG00000177225" "GATD1" "B7ZKW5; hsa:347862; Q2NL76; Q6ZQY0; Q8NAE0; Q8NB37" "" "" "0" "0" "0.977" "0.864" "1.089" "1.042" "1.047" "1.087" "0.954" "0.969" "0.652" "195.5" "191.1" "169.0" "212.9" "203.7" "204.7" "212.6" "186.6" "189.5" "127.5" "" "" "" "" "" "" "" "" "" "" "103.5" "105.9" "96.8" "98.0" "110.2" "113.8" "125.1" "101.8" "106.3" "127.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1425618486899947959" "False" "High" "IsMasterProtein" "Q7Z4H3" "5'-deoxynucleotidase HDDC2 OS=Homo sapiens OX=9606 GN=HDDC2 PE=1 SV=1" "0.000" "False" "7.025" "17" "3" "3" "3" "204" "23.4" "5.49" "2.58" "3" "" "" "other molecular function" "Pf13023" "51020" "ENSG00000111906" "HDDC2" "hsa:51020; Q5TDQ4; Q6NZ49; Q7Z4H3; Q9BTT2; Q9BV31; Q9Y3D1" "" "" "0" "0" "0.965" "0.984" "0.926" "0.977" "0.854" "0.871" "0.845" "0.886" "0.552" "229.6" "221.6" "225.9" "212.6" "224.4" "196.0" "200.1" "194.1" "203.4" "126.7" "" "" "" "" "" "" "" "" "" "" "121.6" "122.9" "129.3" "97.9" "121.4" "109.0" "117.8" "105.9" "114.1" "126.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2291665734159650582" "False" "High" "IsMasterProtein" "P62310" "U6 snRNA-associated Sm-like protein LSm3 OS=Homo sapiens OX=9606 GN=LSM3 PE=1 SV=2" "0.000" "False" "7.021" "12" "1" "2" "1" "102" "11.8" "4.70" "6.71" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "27258" "ENSG00000170860" "LSM3" "hsa:27258; P62310; Q6IAH0; Q9Y4Z1" "" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "2" "0" "1.069" "1.028" "1.146" "0.968" "0.823" "1.168" "1.198" "0.988" "0.446" "195.5" "208.9" "200.9" "224.0" "189.2" "160.8" "228.3" "234.2" "193.1" "87.2" "" "" "" "" "" "" "" "" "" "" "103.5" "115.8" "115.1" "103.2" "102.4" "89.5" "134.4" "127.8" "108.4" "87.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4943228809179220327" "False" "High" "IsMasterProtein" "Q8IWX8" "Calcium homeostasis endoplasmic reticulum protein OS=Homo sapiens OX=9606 GN=CHERP PE=1 SV=3" "0.000" "False" "7.017" "3" "2" "2" "2" "916" "103.6" "9.04" "4.54" "2" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01585, Pf01805, Pf04818" "10523" "ENSG00000085872" "CHERP" "hsa:10523; O00302; Q4G0Y5; Q8IWX8; Q8WU30; Q99492" "" "mRNA Splicing - Major Pathway" "1" "0" "0.934" "1.200" "0.939" "1.094" "1.021" "1.322" "1.172" "1.285" "2.379" "63.0" "58.9" "75.6" "59.2" "68.9" "64.3" "83.3" "73.8" "81.0" "149.9" "" "" "" "" "" "" "" "" "" "" "33.4" "32.6" "43.3" "27.3" "37.3" "35.8" "49.0" "40.3" "45.4" "149.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1664770674535561933" "False" "High" "IsMasterProtein" "Q96T37" "RNA-binding protein 15 OS=Homo sapiens OX=9606 GN=RBM15 PE=1 SV=2" "0.000" "False" "7.016" "4" "2" "2" "2" "977" "107.1" "10.08" "3.04" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf07744" "64783" "ENSG00000162775" "RBM15" "A1A693; hsa:64783; Q3ZB86; Q4V760; Q5D058; Q5T613; Q86VW9; Q96PE4; Q96SC5; Q96SC6; Q96SC9; Q96SD0; Q96T37; Q96T38; Q9BRA5; Q9H6R8; Q9H9Y0" "" "" "0" "0" "0.926" "0.896" "1.344" "1.483" "1.225" "2.201" "2.086" "1.922" "2.024" "32.3" "29.9" "28.9" "43.4" "47.9" "39.6" "71.1" "67.4" "62.1" "65.4" "" "" "" "" "" "" "" "" "" "" "17.1" "16.6" "16.6" "20.0" "25.9" "22.0" "41.8" "36.8" "34.8" "65.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3937524236337839102" "False" "High" "IsMasterProtein" "P32121" "Beta-arrestin-2 OS=Homo sapiens OX=9606 GN=ARRB2 PE=1 SV=2" "0.000" "False" "7.012" "6" "2" "2" "2" "409" "46.1" "7.69" "5.40" "2" "cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00339, Pf02752" "409" "ENSG00000141480" "ARRB2" "B4DLW0; B5B0C0; B7WPL3; D3DTK2; H0Y688; hsa:409; P32121; Q0Z8D3; Q2PP19; Q6ICT3; Q8N7Y2; Q9UEQ6" "Corticotropin-releasing hormone signaling pathway; Complement system; Myometrial relaxation and contraction pathways; Wnt signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Hedgehog signaling pathway; Gastrin signaling pathway; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Calcium regulation in cardiac cells" "Ub-specific processing proteases; Thrombin signalling through proteinase activated receptors (PARs); Activated NOTCH1 Transmits Signal to the Nucleus; Cargo recognition for clathrin-mediated endocytosis; Activation of SMO; G alpha (s) signalling events; Signaling by BRAF and RAF1 fusions; WNT5A-dependent internalization of FZD4; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "27" "0" "1.275" "0.977" "1.247" "1.113" "1.239" "1.078" "0.725" "1.050" "1.690" "16.1" "20.5" "15.7" "20.0" "17.9" "19.9" "17.3" "11.6" "16.9" "27.1" "" "" "" "" "" "" "" "" "" "" "8.5" "11.3" "9.0" "9.2" "9.7" "11.1" "10.2" "6.4" "9.5" "27.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8444524107574200916" "False" "High" "IsMasterProtein" "Q9UH73" "Transcription factor COE1 OS=Homo sapiens OX=9606 GN=EBF1 PE=1 SV=2" "0.000" "False" "6.997" "3" "2" "3" "2" "591" "64.4" "8.76" "8.33" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01833, Pf16422, Pf16423" "1879" "ENSG00000164330" "EBF1" "hsa:1879; Q8IW11; Q9UH73" "Adipogenesis; Prion disease pathway; White fat cell differentiation" "Transcriptional regulation of white adipocyte differentiation; Expression and translocation of olfactory receptors" "5" "0" "0.916" "1.103" "0.877" "1.008" "0.839" "0.951" "0.616" "0.858" "2.804" "59.6" "54.6" "65.7" "52.2" "60.1" "50.0" "56.7" "36.7" "51.1" "167.1" "" "" "" "" "" "" "" "" "" "" "31.6" "30.3" "37.6" "24.1" "32.5" "27.8" "33.4" "20.0" "28.7" "167.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3875322263221301035" "False" "High" "IsMasterProtein" "P51553" "Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3G PE=1 SV=1" "0.000" "False" "6.989" "6" "3" "4" "3" "393" "42.8" "8.50" "11.04" "3" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00180" "3421" "ENSG00000067829" "IDH3G" "E9PDD5; hsa:3421; P51553; Q9BUU5" "TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle); Mitochondrial protein import" "3" "0" "0.994" "0.889" "0.815" "0.970" "0.920" "0.998" "0.865" "0.960" "0.620" "310.1" "308.3" "275.7" "252.7" "300.8" "285.4" "309.7" "268.3" "297.6" "192.4" "" "" "" "" "" "" "" "" "" "" "164.2" "171.0" "157.9" "116.4" "162.7" "158.8" "182.3" "146.4" "167.0" "192.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1927302242065812725" "False" "High" "IsMasterProtein" "P43234" "Cathepsin O OS=Homo sapiens OX=9606 GN=CTSO PE=1 SV=1" "0.000" "False" "6.985" "7" "2" "2" "2" "321" "35.9" "7.42" "5.91" "2" "protein metabolism;other metabolic processes" "non-structural extracellular;other cytoplasmic organelle" "other molecular function" "Pf00112" "1519" "ENSG00000256043; ENSG00000263238" "CTSO" "hsa:1519; P43234" "" "MHC class II antigen presentation" "1" "0" "1.080" "1.114" "1.096" "1.092" "0.895" "1.298" "1.101" "0.986" "0.603" "64.0" "69.2" "71.3" "70.1" "69.9" "57.3" "83.1" "70.5" "63.1" "38.6" "" "" "" "" "" "" "" "" "" "" "33.9" "38.3" "40.8" "32.3" "37.8" "31.9" "48.9" "38.5" "35.4" "38.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6522412944191385699" "False" "High" "IsMasterProtein" "Q9HCM7" "Fibrosin-1-like protein OS=Homo sapiens OX=9606 GN=FBRSL1 PE=1 SV=4" "0.000" "False" "6.984" "1" "1" "1" "1" "1045" "110.8" "9.67" "4.25" "1" "" "" "" "Pf15336" "57666" "ENSG00000112787" "FBRSL1" "hsa:57666; Q86XQ1; Q9HCM7" "" "" "0" "0" "0.964" "0.993" "1.017" "0.917" "0.961" "0.904" "0.981" "0.891" "1.297" "186.1" "179.5" "184.8" "189.2" "170.7" "178.9" "168.3" "182.5" "165.8" "241.3" "" "" "" "" "" "" "" "" "" "" "98.5" "99.5" "105.8" "87.1" "92.4" "99.5" "99.0" "99.6" "93.0" "241.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1094871198918048732" "False" "High" "IsMasterProtein" "O00287" "Regulatory factor X-associated protein OS=Homo sapiens OX=9606 GN=RFXAP PE=1 SV=1" "0.000" "False" "6.982" "8" "2" "2" "2" "272" "28.2" "5.54" "4.03" "2" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf15289" "5994" "ENSG00000133111" "RFXAP" "B2R9T8; hsa:5994; O00287; Q5VZM6; Q8TC40" "" "" "0" "0" "1.078" "1.313" "1.269" "0.678" "0.864" "0.832" "1.071" "0.660" "0.742" "140.9" "151.8" "184.9" "178.8" "95.5" "121.7" "117.2" "150.8" "93.0" "104.6" "" "" "" "" "" "" "" "" "" "" "74.6" "84.2" "105.9" "82.3" "51.6" "67.7" "69.0" "82.3" "52.2" "104.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3585506896184313716" "False" "High" "IsMasterProtein" "P63218" "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 OS=Homo sapiens OX=9606 GN=GNG5 PE=1 SV=3" "0.000" "False" "6.982" "24" "2" "3" "2" "68" "7.3" "9.85" "10.73" "2" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00631" "2787" "ENSG00000174021" "GNG5" "B2R5A0; hsa:2787; P30670; P63218; Q5VX54; Q61015" "Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells; Pathways in cancer" "G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation" "36" "0" "0.974" "1.050" "0.978" "0.873" "0.967" "0.908" "1.024" "0.868" "0.372" "795.9" "775.3" "835.8" "778.1" "694.8" "769.8" "722.3" "814.7" "690.5" "296.3" "" "" "" "" "" "" "" "" "" "" "421.4" "429.8" "478.7" "358.4" "375.9" "428.2" "425.1" "444.7" "387.4" "296.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6370225409205057848" "False" "High" "IsMasterProtein" "Q9UHX1" "Poly(U)-binding-splicing factor PUF60 OS=Homo sapiens OX=9606 GN=PUF60 PE=1 SV=1" "0.000" "False" "6.972" "3" "2" "3" "2" "559" "59.8" "5.29" "10.66" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "22827" "ENSG00000179950" "PUF60" "A8K8K8; hsa:22827; Q969E7; Q96D94; Q96H63; Q99628; Q9NZA0; Q9UHX1; Q9UJY7" "" "mRNA Splicing - Major Pathway" "1" "0" "1.281" "0.877" "0.936" "0.980" "0.945" "1.016" "0.867" "1.026" "2.461" "212.2" "271.8" "186.0" "198.6" "207.8" "200.5" "215.6" "183.9" "217.6" "522.1" "" "" "" "" "" "" "" "" "" "" "112.3" "150.7" "106.5" "91.5" "112.4" "111.5" "126.9" "100.4" "122.1" "522.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2136811018986940550" "False" "High" "IsMasterProtein" "Q9NS91" "E3 ubiquitin-protein ligase RAD18 OS=Homo sapiens OX=9606 GN=RAD18 PE=1 SV=2" "0.000" "False" "6.969" "6" "3" "3" "3" "495" "56.2" "7.58" "3.38" "3" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf13923" "56852" "ENSG00000070950" "RAD18" "Q58F55; Q9NRT6; Q9NS91" "SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome" "Recognition of DNA damage by PCNA-containing replication complex; E3 ubiquitin ligases ubiquitinate target proteins" "3" "0" "1.165" "0.800" "1.329" "1.030" "0.769" "1.253" "0.960" "0.808" "2.716" "42.6" "49.6" "34.1" "56.6" "43.9" "32.7" "53.4" "40.9" "34.4" "115.7" "" "" "" "" "" "" "" "" "" "" "22.6" "27.5" "19.5" "26.1" "23.7" "18.2" "31.4" "22.3" "19.3" "115.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5771737938610614120" "False" "High" "IsMasterProtein" "Q9UPN7" "Serine/threonine-protein phosphatase 6 regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PPP6R1 PE=1 SV=5" "0.000" "False" "6.948" "3" "3" "4" "3" "881" "96.7" "4.55" "10.85" "3" "other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf04499" "22870" "ENSG00000105063" "PPP6R1" "hsa:22870; Q2M2H3; Q504V2; Q6NVJ6; Q9BU97; Q9UPN7" "" "COPII-mediated vesicle transport" "1" "0" "1.054" "1.019" "1.116" "0.960" "0.979" "0.950" "0.837" "0.920" "1.673" "479.6" "505.7" "488.6" "535.0" "460.5" "469.7" "455.4" "401.6" "441.3" "802.5" "" "" "" "" "" "" "" "" "" "" "253.9" "280.4" "279.8" "246.4" "249.1" "261.3" "268.0" "219.2" "247.6" "802.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "546158601093739992" "False" "High" "IsMasterProtein" "Q8N9V3" "WD repeat, SAM and U-box domain-containing protein 1 OS=Homo sapiens OX=9606 GN=WDSUB1 PE=1 SV=4" "0.000" "False" "6.944" "4" "2" "2" "2" "476" "52.8" "6.37" "6.02" "2" "protein metabolism;other metabolic processes" "" "other molecular function" "Pf00400, Pf04564, Pf07647" "151525" "ENSG00000196151" "WDSUB1" "hsa:151525; Q53TI9; Q8N6N8; Q8N9V3" "" "" "0" "0" "0.897" "0.812" "0.908" "0.987" "0.948" "0.851" "0.876" "0.957" "0.749" "254.3" "228.3" "206.5" "231.0" "250.9" "241.1" "216.5" "222.8" "243.4" "190.4" "" "" "" "" "" "" "" "" "" "" "134.7" "126.5" "118.3" "106.4" "135.8" "134.1" "127.4" "121.6" "136.5" "190.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5696513608973606523" "False" "High" "IsMasterProtein" "Q86VQ1" "Glucocorticoid-induced transcript 1 protein OS=Homo sapiens OX=9606 GN=GLCCI1 PE=1 SV=1" "0.000" "False" "6.929" "4" "1" "1" "1" "547" "58.0" "9.44" "4.07" "1" "" "other cell component" "" "Pf15388" "113263" "ENSG00000106415" "GLCCI1" "A4D103; hsa:113263; Q86VQ1; Q96FD0" "" "" "0" "0" "1.178" "1.309" "2.030" "1.778" "1.622" "2.100" "1.795" "0.923" "1.656" "11.6" "13.7" "15.2" "23.6" "20.7" "18.9" "24.4" "20.9" "10.7" "19.3" "" "" "" "" "" "" "" "" "" "" "6.2" "7.6" "8.7" "10.9" "11.2" "10.5" "14.4" "11.4" "6.0" "19.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-652499996560304904" "False" "High" "IsMasterProtein" "P32969" "Large ribosomal subunit protein uL6 OS=Homo sapiens OX=9606 GN=RPL9P9 PE=1 SV=1" "0.000" "False" "6.911" "13" "3" "3" "3" "192" "21.9" "9.95" "7.61" "3" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00347" "6133" "ENSG00000163682" "RPL9; RPL9P7; RPL9P8; RPL9P9" "hsa:6133; P32969" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis" "14" "0" "1.082" "1.122" "1.336" "1.281" "1.333" "1.406" "1.451" "1.362" "1.257" "151.7" "164.2" "170.3" "202.7" "194.3" "202.3" "213.3" "220.2" "206.6" "190.6" "" "" "" "" "" "" "" "" "" "" "80.3" "91.0" "97.5" "93.4" "105.1" "112.5" "125.5" "120.2" "115.9" "190.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6750207652327358618" "False" "High" "IsMasterProtein" "O43719" "17S U2 SnRNP complex component HTATSF1 OS=Homo sapiens OX=9606 GN=HTATSF1 PE=1 SV=1" "0.000" "False" "6.906" "3" "3" "3" "3" "755" "85.8" "4.40" "6.98" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00076" "27336" "ENSG00000102241" "HTATSF1" "D3DWG9; hsa:27336; O43719; Q59G06; Q99730" "" "mRNA Splicing - Major Pathway" "1" "0" "0.857" "1.196" "1.151" "1.030" "1.001" "1.091" "1.039" "1.157" "4.918" "76.9" "65.9" "91.9" "88.4" "79.1" "76.9" "83.8" "79.8" "88.9" "378.0" "" "" "" "" "" "" "" "" "" "" "40.7" "36.5" "52.6" "40.7" "42.8" "42.8" "49.3" "43.6" "49.9" "378.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1386453636298102119" "False" "High" "IsMasterProtein" "Q8NDH3" "Probable aminopeptidase NPEPL1 OS=Homo sapiens OX=9606 GN=NPEPL1 PE=1 SV=3" "0.000" "False" "6.892" "6" "3" "3" "3" "523" "55.8" "6.87" "4.58" "3" "protein metabolism" "other cell component" "other molecular function" "Pf00883, Pf18295" "79716" "ENSG00000215440" "NPEPL1" "A6NGZ0; B4DMW7; B7ZBN0; E9PN47; G5EA34; hsa:79716; Q53G37; Q5W083; Q8NDH3; Q8TF28; Q8WUI2; Q9H1T6; Q9HAI5" "" "" "0" "0" "0.837" "0.881" "1.120" "0.869" "1.009" "1.043" "0.952" "0.989" "0.719" "116.2" "97.3" "102.3" "130.1" "100.9" "117.2" "121.2" "110.6" "114.9" "83.5" "" "" "" "" "" "" "" "" "" "" "61.5" "53.9" "58.6" "59.9" "54.6" "65.2" "71.3" "60.3" "64.5" "83.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2703376622299265366" "False" "High" "IsMasterProtein" "Q9UKF6" "Cleavage and polyadenylation specificity factor subunit 3 OS=Homo sapiens OX=9606 GN=CPSF3 PE=1 SV=1" "0.000" "False" "6.888" "3" "2" "2" "2" "684" "77.4" "5.60" "5.47" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07521, Pf10996, Pf11718, Pf16661" "51692" "ENSG00000119203" "CPSF3" "hsa:51692; O14769; Q53RS2; Q96F36; Q9UKF6" "mRNA processing" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "6" "0" "1.016" "0.913" "1.035" "0.985" "0.944" "1.119" "1.027" "1.016" "2.040" "249.0" "253.1" "227.4" "257.7" "245.2" "235.0" "278.7" "255.8" "253.1" "508.2" "" "" "" "" "" "" "" "" "" "" "131.9" "140.3" "130.2" "118.7" "132.7" "130.7" "164.0" "139.6" "142.0" "508.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3133917976218081073" "False" "High" "IsMasterProtein" "Q9Y3D8" "Adenylate kinase isoenzyme 6 OS=Homo sapiens OX=9606 GN=AK6 PE=1 SV=1" "0.000" "False" "6.884" "11" "2" "2" "2" "172" "20.0" "4.58" "5.11" "2" "other metabolic processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf13238" "102157402" "ENSG00000085231; ENSG00000279247" "AK6" "A8MSZ6; hsa:102157402; Q5F2S9; Q9Y3D8" "" "Interconversion of nucleotide di- and triphosphates" "1" "0" "0.964" "0.809" "1.248" "0.967" "1.089" "1.072" "0.464" "0.973" "7.466" "44.2" "42.7" "35.8" "55.2" "42.8" "48.2" "47.4" "20.5" "43.0" "330.3" "" "" "" "" "" "" "" "" "" "" "23.4" "23.7" "20.5" "25.4" "23.1" "26.8" "27.9" "11.2" "24.1" "330.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2473277628257978921" "False" "High" "IsMasterProtein" "Q5SRE5" "Nucleoporin NUP188 OS=Homo sapiens OX=9606 GN=NUP188 PE=1 SV=1" "0.000" "False" "6.876" "1" "2" "2" "2" "1749" "195.9" "6.73" "4.50" "2" "transport" "cytosol;nucleus" "other molecular function" "Pf10487, Pf21093, Pf21094" "23511" "ENSG00000095319" "NUP188" "hsa:23511; Q14675; Q2TA87; Q5SRE5; Q7Z3K8; Q8IWF1" "" "Vpr-mediated nuclear import of PICs; Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; SUMOylation of chromatin organization proteins; HCMV Early Events; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "29" "0" "0.972" "1.057" "0.877" "0.919" "0.900" "0.845" "1.000" "1.120" "0.663" "158.7" "154.4" "167.7" "139.1" "145.9" "142.8" "134.1" "158.8" "177.8" "105.2" "" "" "" "" "" "" "" "" "" "" "84.1" "85.6" "96.1" "64.1" "78.9" "79.4" "78.9" "86.7" "99.8" "105.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-421733537835387635" "False" "High" "IsMasterProtein" "Q9NPE2" "Neugrin OS=Homo sapiens OX=9606 GN=NGRN PE=1 SV=2" "0.000" "False" "6.868" "7" "2" "2" "2" "291" "32.4" "9.10" "4.60" "2" "cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf06413" "51335" "ENSG00000182768" "NGRN" "B2R6M8; hsa:51335; Q4V9L7; Q9HBL4; Q9NPE2" "" "" "0" "0" "0.939" "0.831" "0.864" "0.862" "0.828" "0.830" "0.808" "0.953" "0.565" "94.0" "88.2" "78.1" "81.2" "81.1" "77.8" "78.0" "75.9" "89.6" "53.1" "" "" "" "" "" "" "" "" "" "" "49.8" "48.9" "44.7" "37.4" "43.9" "43.3" "45.9" "41.4" "50.2" "53.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3668121595413898342" "False" "High" "IsMasterProtein" "Q96D46" "60S ribosomal export protein NMD3 OS=Homo sapiens OX=9606 GN=NMD3 PE=1 SV=1" "0.000" "False" "6.860" "6" "4" "5" "4" "503" "57.6" "7.14" "6.35" "4" "transport;other biological processes" "nucleus;other cell component" "translation activity;other molecular function" "Pf04981, Pf21192, Pf21193" "51068" "ENSG00000169251" "NMD3" "D3DNM7; hsa:51068; Q96D46; Q9Y2Z6" "" "" "0" "0" "1.059" "1.043" "1.046" "1.001" "1.123" "0.979" "0.966" "0.876" "1.056" "469.4" "496.9" "489.6" "491.2" "469.8" "527.0" "459.5" "453.6" "411.4" "495.7" "" "" "" "" "" "" "" "" "" "" "248.5" "275.5" "280.4" "226.2" "254.2" "293.2" "270.5" "247.6" "230.8" "495.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3823742586445689125" "False" "High" "IsMasterProtein" "Q9NPQ8" "Synembryn-A OS=Homo sapiens OX=9606 GN=RIC8A PE=1 SV=3" "0.000" "False" "6.836" "5" "3" "3" "3" "531" "59.7" "5.33" "7.26" "3" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf10165" "60626" "ENSG00000177963" "RIC8A" "hsa:60626; Q0P508; Q2T9J1; Q7Z352; Q96EZ1; Q96SZ2; Q9H064; Q9H5H3; Q9H9E7; Q9NPQ8" "" "" "0" "0" "1.162" "0.940" "1.106" "0.986" "1.115" "1.163" "0.723" "0.941" "3.827" "132.4" "153.9" "124.6" "146.4" "130.5" "147.6" "154.0" "95.7" "124.6" "506.9" "" "" "" "" "" "" "" "" "" "" "70.1" "85.3" "71.3" "67.4" "70.6" "82.1" "90.6" "52.3" "69.9" "506.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2874142018275296018" "False" "High" "IsMasterProtein" "A6NHR9" "Structural maintenance of chromosomes flexible hinge domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SMCHD1 PE=1 SV=2" "0.000" "False" "6.809" "1" "2" "2" "2" "2005" "226.2" "7.30" "5.16" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06470, Pf13589" "23347" "ENSG00000101596" "SMCHD1" "A6NHR9; O75141; Q6AHX6; Q6ZTQ8; Q9H6Q2; Q9UG39" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4875148632163355861" "False" "High" "IsMasterProtein" "Q9Y3D2" "Methionine-R-sulfoxide reductase B2, mitochondrial OS=Homo sapiens OX=9606 GN=MSRB2 PE=1 SV=2" "0.000" "False" "6.808" "5" "2" "2" "2" "182" "19.5" "8.63" "7.29" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf01641" "22921" "ENSG00000148450" "MSRB2" "hsa:22921; Q17R44; Q4G1C7; Q9Y3D2; Q9Y5W6" "Sulindac metabolic pathway; Methionine de novo and salvage pathway" "Protein repair" "3" "0" "0.992" "1.100" "1.174" "1.047" "0.985" "0.988" "1.034" "0.978" "0.763" "423.0" "419.6" "465.3" "496.7" "442.8" "416.9" "418.0" "437.2" "413.8" "322.9" "" "" "" "" "" "" "" "" "" "" "224.0" "232.6" "266.5" "228.8" "239.6" "231.9" "246.0" "238.7" "232.1" "322.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3173318319984318675" "False" "High" "IsMasterProtein" "Q9BXR0" "Queuine tRNA-ribosyltransferase catalytic subunit 1 OS=Homo sapiens OX=9606 GN=QTRT1 PE=1 SV=3" "0.000" "False" "6.802" "3" "1" "2" "1" "403" "44.0" "7.23" "8.66" "1" "RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01702" "81890" "ENSG00000213339" "QTRT1" "B4DFM7; hsa:81890; Q96BQ4; Q9BXQ9; Q9BXR0" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.965" "1.010" "0.937" "1.001" "0.958" "1.067" "1.016" "1.052" "0.798" "251.5" "242.6" "254.0" "235.5" "251.6" "240.8" "268.4" "255.4" "264.5" "200.6" "" "" "" "" "" "" "" "" "" "" "133.1" "134.5" "145.5" "108.5" "136.1" "133.9" "157.9" "139.4" "148.4" "200.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7812930813486390808" "False" "High" "IsMasterProtein" "Q9Y2J2" "Band 4.1-like protein 3 OS=Homo sapiens OX=9606 GN=EPB41L3 PE=1 SV=2" "0.000" "False" "6.801" "3" "4" "4" "1" "1087" "120.6" "5.19" "7.77" "4" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380" "23136" "ENSG00000082397" "EPB41L3" "B7Z4I5; F5GX05; hsa:23136; O95713; Q9BRP5; Q9Y2J2" "Splicing factor NOVA regulated synaptic proteins; 7q11.23 distal copy number variation" "Neurexins and neuroligins; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2735556346422021928" "False" "High" "IsMasterProtein" "P53384" "Cytosolic Fe-S cluster assembly factor NUBP1 OS=Homo sapiens OX=9606 GN=NUBP1 PE=1 SV=2" "0.000" "False" "6.798" "11" "3" "4" "3" "320" "34.5" "5.33" "4.66" "3" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10609" "4682" "ENSG00000103274" "NUBP1" "hsa:4682; P53384; Q32M30; Q498A9; Q53FS7" "Iron-sulfur cluster biogenesis" "Cytosolic iron-sulfur cluster assembly" "2" "0" "1.252" "1.149" "1.082" "1.157" "1.039" "0.904" "0.970" "1.084" "0.866" "56.0" "70.1" "64.3" "60.6" "64.8" "58.2" "50.6" "54.3" "60.7" "48.5" "" "" "" "" "" "" "" "" "" "" "29.6" "38.9" "36.8" "27.9" "35.1" "32.3" "29.8" "29.7" "34.0" "48.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9176436912319366181" "False" "High" "IsMasterProtein" "Q9Y5Q9" "General transcription factor 3C polypeptide 3 OS=Homo sapiens OX=9606 GN=GTF3C3 PE=1 SV=1" "0.000" "False" "6.796" "2" "2" "3" "2" "886" "101.2" "5.07" "7.88" "2" "RNA metabolism OR transcription;other metabolic processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13181" "9330" "ENSG00000119041" "GTF3C3" "hsa:9330; Q4ZG48; Q86XJ8; Q8WX84; Q96B44; Q9H5I8; Q9NT97; Q9Y5Q9" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "3" "0" "0.899" "1.011" "1.146" "0.982" "1.000" "1.516" "1.183" "1.275" "2.686" "161.1" "144.8" "162.9" "184.7" "158.2" "161.1" "244.3" "190.6" "205.5" "432.8" "" "" "" "" "" "" "" "" "" "" "85.3" "80.3" "93.3" "85.0" "85.6" "89.6" "143.8" "104.0" "115.3" "432.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8876035733125179295" "False" "High" "IsMasterProtein" "Q96D71" "RalBP1-associated Eps domain-containing protein 1 OS=Homo sapiens OX=9606 GN=REPS1 PE=1 SV=3" "0.000" "False" "6.776" "3" "3" "3" "3" "796" "86.6" "5.69" "4.72" "3" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12763" "85021" "ENSG00000135597" "REPS1" "B7ZBZ8; B7ZBZ9; B7ZC00; hsa:85021; J3KP76; Q5JWJ5; Q5JWJ6; Q5JWJ7; Q8NDR7; Q8WU62; Q96D71; Q9BXY9" "" "Cargo recognition for clathrin-mediated endocytosis" "2" "0" "1.317" "1.246" "1.273" "1.301" "0.940" "1.173" "1.004" "1.396" "3.869" "42.7" "56.3" "53.3" "54.4" "55.6" "40.2" "50.1" "42.9" "59.7" "165.4" "" "" "" "" "" "" "" "" "" "" "22.6" "31.2" "30.5" "25.1" "30.1" "22.4" "29.5" "23.4" "33.5" "165.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7952691654267697192" "False" "High" "IsMasterProtein" "Q15067" "Peroxisomal acyl-coenzyme A oxidase 1 OS=Homo sapiens OX=9606 GN=ACOX1 PE=1 SV=3" "0.000" "False" "6.758" "4" "3" "4" "3" "660" "74.4" "8.16" "7.31" "3" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;cytosol;other cytoplasmic organelle" "other molecular function" "Pf01756, Pf02770, Pf14749" "51" "ENSG00000161533" "ACOX1" "A8K6X8; A8KAA0; B4DK61; F5GYQ8; hsa:51; Q12863; Q15067; Q15068; Q15101; Q16131; Q7Z3W5; Q9UD31" "Estrogen receptor pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-3 / omega-6 fatty acid synthesis" "TYSND1 cleaves peroxisomal proteins" "8" "0" "1.120" "1.171" "0.938" "1.298" "1.267" "0.977" "1.052" "0.963" "0.669" "166.0" "185.8" "194.3" "155.6" "215.4" "210.2" "162.2" "174.6" "159.8" "111.1" "" "" "" "" "" "" "" "" "" "" "87.9" "103.0" "111.3" "71.7" "116.5" "116.9" "95.5" "95.3" "89.6" "111.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5610453000666898366" "False" "High" "IsMasterProtein" "Q6RFH5" "WD repeat-containing protein 74 OS=Homo sapiens OX=9606 GN=WDR74 PE=1 SV=1" "0.000" "False" "6.751" "6" "2" "3" "2" "385" "42.4" "8.32" "6.98" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf00400" "54663" "ENSG00000133316" "WDR74" "A8K8G5; hsa:54663; Q6RFH5; Q9BRC9; Q9H6X8; Q9NVY2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8443546389451323737" "False" "High" "IsMasterProtein" "Q96HJ9" "Protein FMC1 homolog OS=Homo sapiens OX=9606 GN=FMC1 PE=1 SV=2" "0.000" "False" "6.739" "18" "2" "2" "2" "113" "12.7" "10.07" "6.04" "2" "cell organization and biogenesis;other biological processes" "mitochondrion" "" "Pf13233" "100996928; 154791" "ENSG00000164898" "FMC1" "B7Z4Q3; hsa:100996928; hsa:154791; Q75M90; Q96HJ9; Q9P0B3" "" "" "0" "0" "0.915" "0.862" "1.124" "0.903" "0.998" "0.914" "0.912" "0.864" "0.514" "124.6" "114.0" "107.4" "140.1" "112.5" "124.4" "113.9" "113.6" "107.6" "64.0" "" "" "" "" "" "" "" "" "" "" "66.0" "63.2" "61.5" "64.5" "60.9" "69.2" "67.0" "62.0" "60.4" "64.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7667668452715930583" "False" "High" "IsMasterProtein" "O60264" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 OS=Homo sapiens OX=9606 GN=SMARCA5 PE=1 SV=1" "0.000" "False" "6.735" "2" "2" "2" "2" "1052" "121.8" "8.09" "6.40" "2" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf09110, Pf09111" "8467" "ENSG00000153147" "SMARCA5" "hsa:8467; O60264" "10q11.21q11.23 copy number variation syndrome" "Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; NoRC negatively regulates rRNA expression" "5" "0" "1.046" "1.011" "1.196" "0.987" "1.103" "0.903" "0.439" "1.177" "6.855" "55.0" "57.5" "55.6" "65.8" "54.2" "60.7" "49.6" "24.2" "64.7" "376.9" "" "" "" "" "" "" "" "" "" "" "29.1" "31.9" "31.8" "30.3" "29.3" "33.7" "29.2" "13.2" "36.3" "376.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3327370381573557729" "False" "High" "IsMasterProtein" "Q99611" "Selenide, water dikinase 2 OS=Homo sapiens OX=9606 GN=SEPHS2 PE=1 SV=3" "0.000" "False" "6.733" "6" "2" "2" "1" "448" "47.3" "5.88" "2.43" "2" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00586, Pf02769" "22928" "ENSG00000179918" "SEPHS2" "hsa:22928; Q99611; Q9BUQ2" "Selenium micronutrient network; Selenium metabolism and selenoproteins" "Selenocysteine synthesis" "3" "0" "0.880" "1.102" "1.331" "1.049" "0.849" "0.926" "1.023" "1.228" "0.676" "46.8" "41.1" "51.5" "62.2" "49.0" "39.7" "43.3" "47.8" "57.4" "31.6" "" "" "" "" "" "" "" "" "" "" "24.8" "22.8" "29.5" "28.7" "26.5" "22.1" "25.5" "26.1" "32.2" "31.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6751278663907923034" "False" "High" "IsMasterProtein" "Q9UFG5" "UPF0449 protein C19orf25 OS=Homo sapiens OX=9606 GN=C19orf25 PE=1 SV=2" "0.000" "False" "6.729" "18" "2" "3" "2" "118" "12.9" "5.07" "7.25" "2" "" "" "" "Pf15136" "148223" "ENSG00000119559" "C19orf25" "B3KQN6; hsa:148223; Q8N9R7; Q8WV94; Q9UFG5" "" "" "0" "0" "1.234" "1.048" "0.999" "0.991" "1.002" "1.002" "1.031" "1.034" "0.493" "299.4" "369.5" "313.8" "299.1" "296.9" "300.2" "299.9" "308.6" "309.7" "147.6" "" "" "" "" "" "" "" "" "" "" "158.6" "204.8" "179.7" "137.7" "160.6" "167.0" "176.5" "168.4" "173.7" "147.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-410624310622087342" "False" "High" "IsMasterProtein" "Q13227" "G protein pathway suppressor 2 OS=Homo sapiens OX=9606 GN=GPS2 PE=1 SV=3" "0.000" "False" "6.724" "7" "3" "4" "3" "327" "36.7" "9.52" "6.92" "3" "stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf15991" "2874" "ENSG00000132522; ENSG00000288325" "GPS2" "B4DXA1; hsa:2874; Q13227; Q6FHM8" "Rett syndrome" "HDACs deacetylate histones; PPARA activates gene expression; HCMV Early Events; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2667466145755123608" "False" "High" "IsMasterProtein" "O75380" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS6 PE=1 SV=1" "0.000" "False" "6.720" "20" "3" "3" "3" "124" "13.7" "8.28" "7.97" "3" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf10276" "4726" "ENSG00000145494" "NDUFS6" "hsa:4726; O75380" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "1.011" "1.082" "0.959" "1.080" "0.953" "1.021" "0.992" "1.081" "0.429" "443.5" "448.5" "480.1" "425.4" "479.1" "422.5" "453.0" "440.1" "479.3" "190.1" "" "" "" "" "" "" "" "" "" "" "234.8" "248.7" "274.9" "195.9" "259.2" "235.0" "266.6" "240.2" "268.9" "190.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6782447041087316008" "False" "High" "IsMasterProtein" "Q9UNF0" "Protein kinase C and casein kinase substrate in neurons protein 2 OS=Homo sapiens OX=9606 GN=PACSIN2 PE=1 SV=2" "0.000" "False" "6.716" "5" "3" "3" "3" "486" "55.7" "5.20" "7.34" "3" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00611, Pf14604" "11252" "ENSG00000100266" "PACSIN2" "hsa:11252; O95921; Q96HV9; Q9H0D3; Q9NPN1; Q9UNF0; Q9Y4V2" "" "Clathrin-mediated endocytosis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5875198809388005970" "False" "High" "IsMasterProtein" "Q9H3H3" "UPF0696 protein C11orf68 OS=Homo sapiens OX=9606 GN=C11orf68 PE=1 SV=3" "0.000" "False" "6.716" "6" "2" "4" "2" "292" "31.4" "6.32" "12.41" "2" "" "" "" "Pf08939" "83638" "ENSG00000175573" "C11orf68" "hsa:83638; J3KQG9; Q9BT13; Q9H3H3" "" "" "0" "0" "0.947" "0.867" "0.890" "1.035" "0.969" "1.032" "0.889" "0.921" "0.740" "80.0" "75.7" "69.4" "71.1" "82.8" "77.5" "82.6" "71.1" "73.6" "59.2" "" "" "" "" "" "" "" "" "" "" "42.3" "42.0" "39.7" "32.8" "44.8" "43.1" "48.6" "38.8" "41.3" "59.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1558588285545917257" "False" "High" "IsMasterProtein" "O75531" "Barrier-to-autointegration factor OS=Homo sapiens OX=9606 GN=BANF1 PE=1 SV=1" "0.000" "False" "6.713" "17" "2" "4" "2" "89" "10.1" "6.09" "10.49" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02961" "8815" "ENSG00000175334" "BANF1" "hsa:8815; O60558; O75531; Q6FGG7" "Envelope proteins and their potential roles in EDMD physiopathology; Familial partial lipodystrophy; Progeria-associated lipodystrophy" "Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Nuclear Envelope Breakdown; Initiation of Nuclear Envelope (NE) Reformation" "11" "0" "0.843" "1.003" "0.886" "0.859" "0.806" "0.780" "0.930" "0.793" "0.143" "563.4" "475.1" "565.0" "499.2" "484.1" "454.2" "439.4" "523.7" "447.0" "80.8" "" "" "" "" "" "" "" "" "" "" "298.3" "263.4" "323.6" "229.9" "261.9" "252.6" "258.6" "285.9" "250.7" "80.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1697211468385276031" "False" "High" "IsMasterProtein" "P62861" "Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein OS=Homo sapiens OX=9606 GN=FAU PE=1 SV=2" "0.000" "False" "6.709" "8" "1" "2" "1" "133" "14.4" "10.17" "1.97" "1" "protein metabolism;other metabolic processes;stress response" "non-structural extracellular;cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00240, Pf04758" "2197" "ENSG00000149806" "FAU" "hsa:2197; P35544; P62861; Q05472; Q95261; Q9H5V4" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Formation of the ternary complex, and subsequently, the 43S complex; SARS-CoV-1 modulates host translation machinery" "19" "0" "1.237" "1.166" "1.304" "1.061" "1.291" "2.042" "1.596" "1.925" "0.481" "39.5" "48.9" "46.1" "51.5" "41.9" "51.0" "80.7" "63.1" "76.1" "19.0" "" "" "" "" "" "" "" "" "" "" "20.9" "27.1" "26.4" "23.7" "22.7" "28.4" "47.5" "34.4" "42.7" "19.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1047661720353379507" "False" "High" "IsMasterProtein" "Q03426" "Mevalonate kinase OS=Homo sapiens OX=9606 GN=MVK PE=1 SV=1" "0.000" "False" "6.701" "6" "3" "5" "3" "396" "42.4" "6.46" "12.80" "3" "other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00288, Pf08544" "4598" "ENSG00000110921" "MVK" "hsa:4598; Q03426" "Cholesterol biosynthesis pathway; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "8" "0" "0.987" "0.994" "1.023" "1.013" "1.032" "0.906" "0.904" "0.891" "0.612" "515.0" "508.4" "511.8" "527.0" "521.7" "531.5" "466.8" "465.8" "458.9" "315.2" "" "" "" "" "" "" "" "" "" "" "272.7" "281.9" "293.1" "242.7" "282.3" "295.6" "274.7" "254.2" "257.4" "315.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6705073720058711891" "False" "High" "IsMasterProtein" "Q96BP2" "Small ribosomal subunit protein mS37 OS=Homo sapiens OX=9606 GN=CHCHD1 PE=1 SV=1" "0.000" "False" "6.700" "9" "1" "1" "1" "118" "13.5" "10.21" "3.81" "1" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus;nucleus" "" "Pf06747" "118487" "ENSG00000172586" "CHCHD1" "hsa:118487; Q96BP2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.142" "1.229" "1.258" "1.220" "1.035" "1.197" "1.237" "1.131" "0.998" "110.6" "126.3" "135.9" "139.1" "134.9" "114.4" "132.3" "136.8" "125.0" "110.4" "" "" "" "" "" "" "" "" "" "" "58.5" "70.0" "77.8" "64.1" "73.0" "63.7" "77.9" "74.7" "70.1" "110.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8911180821409162451" "False" "High" "IsMasterProtein" "Q9NYB9" "Abl interactor 2 OS=Homo sapiens OX=9606 GN=ABI2 PE=1 SV=1" "0.000" "False" "6.693" "6" "2" "2" "1" "513" "55.6" "6.16" "5.69" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00018, Pf07815" "10152" "ENSG00000138443" "ABI2" "B4DSN1; hsa:10152; Q13147; Q13249; Q13801; Q9BV70; Q9NYB9" "Regulation of actin cytoskeleton" "RAC1 GTPase cycle; RAC3 GTPase cycle; RAC2 GTPase cycle; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs" "8" "0" "1.464" "1.612" "1.416" "1.078" "1.244" "1.178" "1.144" "1.264" "2.056" "27.5" "40.3" "44.4" "39.0" "29.7" "34.2" "32.4" "31.5" "34.8" "56.6" "" "" "" "" "" "" "" "" "" "" "14.6" "22.3" "25.4" "17.9" "16.0" "19.0" "19.1" "17.2" "19.5" "56.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8448471456180421378" "False" "High" "IsMasterProtein" "Q9P275" "Ubiquitin carboxyl-terminal hydrolase 36 OS=Homo sapiens OX=9606 GN=USP36 PE=1 SV=4" "0.000" "False" "6.686" "2" "3" "3" "3" "1123" "122.8" "9.70" "8.19" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443" "57602" "ENSG00000055483" "USP36" "hsa:57602; Q05C98; Q05DD0; Q6IQ38; Q8NDM8; Q9NVC8; Q9P275" "" "" "0" "0" "0.907" "0.879" "1.205" "1.049" "0.869" "1.709" "1.485" "1.690" "0.916" "139.0" "126.2" "122.2" "167.5" "145.9" "120.8" "237.6" "206.5" "234.9" "127.3" "" "" "" "" "" "" "" "" "" "" "73.6" "70.0" "70.0" "77.1" "78.9" "67.2" "139.9" "112.7" "131.8" "127.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1728061732538429863" "False" "High" "IsMasterProtein" "Q9UQC2" "GRB2-associated-binding protein 2 OS=Homo sapiens OX=9606 GN=GAB2 PE=1 SV=1" "0.000" "False" "6.684" "4" "3" "3" "3" "676" "74.4" "8.31" "4.22" "3" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00169" "9846" "ENSG00000033327" "GAB2" "A2RRM2; A6NEW9; A7MD36; hsa:9846; O60317; Q9UQC2" "RANKL/RANK signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Imatinib and chronic myeloid leukemia; BDNF-TrkB signaling; IL-4 signaling pathway; Ras signaling; EGF/EGFR signaling pathway; IL-2 signaling pathway; GDNF signaling; Interferon type I signaling pathways; T-cell receptor signaling pathway" "PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by SCF-KIT; Signaling by CSF3 (G-CSF); Signaling by cytosolic FGFR1 fusion mutants; Signaling by FLT3 fusion proteins; STAT5 activation downstream of FLT3 ITD mutants; Interleukin-15 signaling; STAT5 Activation; Role of LAT2/NTAL/LAB on calcium mobilization; RET signaling; Interleukin receptor SHC signaling; PI3K Cascade; Signaling by CSF1 (M-CSF) in myeloid cells; Signaling by FLT3 ITD and TKD mutants" "32" "0" "1.273" "1.302" "1.342" "1.466" "1.381" "1.934" "1.623" "1.724" "2.209" "51.4" "65.4" "66.9" "68.9" "75.3" "71.0" "99.4" "83.4" "88.6" "113.5" "" "" "" "" "" "" "" "" "" "" "27.2" "36.3" "38.3" "31.7" "40.7" "39.5" "58.5" "45.5" "49.7" "113.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3013067335374835843" "False" "High" "IsMasterProtein" "Q13153" "Serine/threonine-protein kinase PAK 1 OS=Homo sapiens OX=9606 GN=PAK1 PE=1 SV=2" "0.000" "False" "6.682" "4" "2" "2" "1" "545" "60.6" "5.76" "6.00" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00786" "5058" "ENSG00000149269" "PAK1" "hsa:5058; O75561; Q13153; Q13567; Q32M53; Q32M54; Q86W79" "Integrin-mediated cell adhesion; Prolactin signaling pathway; Microtubule cytoskeleton regulation; Androgen receptor network in prostate cancer; Focal adhesion; Hepatocyte growth factor receptor signaling; Fas ligand pathway and stress induction of heat shock proteins; RAC1/PAK1/p38/MMP2 pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; Gastrin signaling pathway; Melanoma; Pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway; T-cell receptor signaling pathway" "CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOU GTPase cycle; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs; MAPK6/MAPK4 signaling; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; Generation of second messenger molecules; RHOQ GTPase cycle; RHOV GTPase cycle; EPHB-mediated forward signaling; Ephrin signaling; G beta:gamma signalling through CDC42; Sema3A PAK dependent Axon repulsion; Signal transduction by L1; DSCAM interactions; VEGFR2 mediated vascular permeability; Activation of RAC1; RHOH GTPase cycle; CD209 (DC-SIGN) signaling; CD28 dependent Vav1 pathway" "56" "0" "0.929" "1.045" "1.244" "1.029" "0.959" "0.971" "0.963" "0.975" "0.628" "113.4" "105.3" "118.5" "141.1" "116.6" "108.7" "110.1" "109.2" "110.5" "71.2" "" "" "" "" "" "" "" "" "" "" "60.0" "58.4" "67.9" "65.0" "63.1" "60.5" "64.8" "59.6" "62.0" "71.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5357648313694038384" "False" "High" "IsMasterProtein" "Q8IUD2" "ELKS/Rab6-interacting/CAST family member 1 OS=Homo sapiens OX=9606 GN=ERC1 PE=1 SV=1" "0.000" "False" "6.681" "3" "3" "3" "3" "1116" "128.0" "5.97" "1.97" "3" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf09457, Pf10174" "23085" "ENSG00000082805" "ERC1" "A2RU77; A7E295; D3DUP7; D3DUP8; hsa:23085; Q6NVK2; Q8IUD2; Q8IUD3; Q8IUD4; Q8IUD5; Q8NAS1; Q9NXN5; Q9UIK7; Q9UPS1" "Cell lineage map for neuronal differentiation" "" "1" "0" "1.058" "0.942" "1.071" "1.271" "0.982" "1.379" "0.783" "0.839" "2.664" "30.5" "32.3" "28.7" "32.7" "38.8" "30.0" "42.1" "23.9" "25.6" "81.3" "" "" "" "" "" "" "" "" "" "" "16.2" "17.9" "16.5" "15.0" "21.0" "16.7" "24.8" "13.0" "14.4" "81.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1811232654349558643" "False" "High" "IsMasterProtein" "P18846" "Cyclic AMP-dependent transcription factor ATF-1 OS=Homo sapiens OX=9606 GN=ATF1 PE=1 SV=2" "0.000" "False" "6.681" "8" "3" "4" "2" "271" "29.2" "8.37" "7.18" "3" "cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf02173" "466" "ENSG00000123268" "ATF1" "B4DRF9; hsa:466; P18846; P25168; Q9H4A8" "Integrated cancer pathway; Androgen receptor network in prostate cancer; Interleukin-11 signaling pathway; Myometrial relaxation and contraction pathways; EGF/EGFR signaling pathway; GDNF signaling; Serotonin receptor 4/6/7 and NR3C signaling" "NGF-stimulated transcription; CREB phosphorylation" "9" "0" "0.955" "1.034" "0.939" "0.954" "0.941" "0.938" "1.020" "0.964" "0.515" "401.8" "383.6" "415.3" "377.1" "383.4" "378.1" "376.7" "410.0" "387.2" "207.0" "" "" "" "" "" "" "" "" "" "" "212.7" "212.7" "237.8" "173.7" "207.4" "210.3" "221.7" "223.8" "217.2" "207.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2036911108115043510" "False" "High" "IsMasterProtein" "Q96F86" "Enhancer of mRNA-decapping protein 3 OS=Homo sapiens OX=9606 GN=EDC3 PE=1 SV=1" "0.000" "False" "6.679" "5" "3" "4" "3" "508" "56.0" "7.11" "9.48" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf03853, Pf09532, Pf12701, Pf16598" "80153" "ENSG00000179151" "EDC3" "B3KPH0; D3DW61; hsa:80153; Q96F86; Q9H797" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "0.906" "0.976" "1.166" "1.129" "0.974" "1.134" "0.980" "1.040" "1.921" "202.7" "183.6" "197.9" "236.2" "228.9" "197.5" "229.9" "198.7" "210.8" "389.4" "" "" "" "" "" "" "" "" "" "" "107.3" "101.8" "113.3" "108.8" "123.8" "109.9" "135.3" "108.5" "118.2" "389.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3718082725162177882" "False" "High" "IsMasterProtein" "O95822" "Malonyl-CoA decarboxylase, mitochondrial OS=Homo sapiens OX=9606 GN=MLYCD PE=1 SV=3" "0.000" "False" "6.676" "5" "2" "2" "2" "493" "55.0" "8.95" "4.48" "2" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05292, Pf17408" "23417" "ENSG00000103150" "MLYCD" "hsa:23417; O95822; Q9UNU5; Q9Y3F2" "" "" "0" "0" "1.426" "0.884" "1.285" "1.297" "1.312" "1.195" "1.074" "0.930" "1.085" "37.1" "52.9" "32.8" "47.7" "48.1" "48.7" "44.4" "39.9" "34.5" "40.3" "" "" "" "" "" "" "" "" "" "" "19.7" "29.3" "18.8" "22.0" "26.0" "27.1" "26.1" "21.8" "19.4" "40.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3335218336630157461" "False" "High" "IsMasterProtein" "Q9UFN0" "Protein NipSnap homolog 3A OS=Homo sapiens OX=9606 GN=NIPSNAP3A PE=1 SV=2" "0.000" "False" "6.652" "11" "3" "4" "3" "247" "28.4" "9.16" "4.94" "3" "" "cytosol;mitochondrion" "" "Pf07978" "25934" "ENSG00000136783" "NIPSNAP3A" "A6NM55; hsa:25934; Q5VX32; Q9BRV7; Q9H843; Q9P083; Q9UFN0" "" "" "0" "0" "0.938" "0.854" "0.763" "0.978" "0.771" "0.859" "0.851" "0.817" "0.664" "207.3" "194.5" "176.9" "158.1" "202.7" "159.7" "178.1" "176.3" "169.4" "137.6" "" "" "" "" "" "" "" "" "" "" "109.7" "107.8" "101.3" "72.8" "109.7" "88.8" "104.8" "96.2" "95.0" "137.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8411894831205011543" "False" "High" "IsMasterProtein" "Q7L8J4" "SH3 domain-binding protein 5-like OS=Homo sapiens OX=9606 GN=SH3BP5L PE=1 SV=1" "0.000" "False" "6.650" "6" "3" "3" "3" "393" "43.5" "5.77" "6.25" "3" "signal transduction" "other cell component" "enzyme regulator activity" "Pf05276" "80851" "ENSG00000175137" "SH3BP5L" "B4DQ94; hsa:80851; Q7L8J4; Q96FI5; Q9BQH8; Q9C0E3" "" "" "0" "0" "1.025" "1.044" "1.051" "1.016" "0.926" "0.865" "0.947" "0.928" "1.086" "561.3" "575.3" "586.1" "589.7" "570.4" "519.9" "485.6" "531.7" "520.9" "609.8" "" "" "" "" "" "" "" "" "" "" "297.2" "319.0" "335.7" "271.6" "308.6" "289.2" "285.8" "290.2" "292.2" "609.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4563440572163449089" "False" "High" "IsMasterProtein" "P60520" "Gamma-aminobutyric acid receptor-associated protein-like 2 OS=Homo sapiens OX=9606 GN=GABARAPL2 PE=1 SV=1" "0.000" "False" "6.649" "21" "3" "4" "3" "117" "13.7" "8.10" "9.95" "3" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf02991" "11345" "ENSG00000034713" "GABARAPL2" "hsa:11345; O08765; P60520; Q6FG91; Q9DCP8; Q9UQF7" "Network map of SARS-CoV-2 signaling pathway; 2q37 copy number variation syndrome; 8q11.23 (RB1CC1) copy number variation" "TBC/RABGAPs; Macroautophagy" "5" "0" "1.052" "1.036" "1.081" "0.989" "0.973" "1.014" "1.046" "1.008" "0.745" "307.2" "323.1" "318.2" "332.1" "304.0" "298.8" "311.4" "321.4" "309.8" "229.0" "" "" "" "" "" "" "" "" "" "" "162.7" "179.1" "182.3" "152.9" "164.5" "166.2" "183.3" "175.4" "173.8" "229.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4235790517375748562" "False" "High" "IsMasterProtein" "O43924" "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta OS=Homo sapiens OX=9606 GN=PDE6D PE=1 SV=1" "0.000" "False" "6.648" "16" "2" "3" "2" "150" "17.4" "5.67" "8.03" "2" "other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf05351" "5147" "ENSG00000156973" "PDE6D" "hsa:5147; O43250; O43924" "Phosphodiesterases in neuronal function; Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "ARL13B-mediated ciliary trafficking of INPP5E; RAS processing" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8357658854123366068" "False" "High" "IsMasterProtein" "O00629" "Importin subunit alpha-3 OS=Homo sapiens OX=9606 GN=KPNA4 PE=1 SV=1" "0.000" "False" "6.645" "5" "3" "4" "1" "521" "57.9" "4.96" "10.53" "3" "cell-cell signaling;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3840" "ENSG00000186432" "KPNA4" "A8K4S6; D3DNM2; hsa:3840; O00190; O00629" "Leptin signaling pathway" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways" "3" "0" "1.120" "0.936" "1.307" "1.167" "1.111" "1.439" "1.116" "1.064" "1.905" "66.0" "74.0" "61.8" "86.3" "77.1" "73.3" "95.0" "73.7" "70.3" "125.8" "" "" "" "" "" "" "" "" "" "" "35.0" "41.0" "35.4" "39.7" "41.7" "40.8" "55.9" "40.2" "39.4" "125.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7903572994601535827" "False" "High" "IsMasterProtein" "Q9Y6N5" "Sulfide:quinone oxidoreductase, mitochondrial OS=Homo sapiens OX=9606 GN=SQOR PE=1 SV=1" "0.000" "False" "6.633" "6" "2" "2" "2" "450" "49.9" "9.11" "2.74" "2" "other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf07992" "58472" "ENSG00000137767" "SQOR" "hsa:58472; Q9UQM8; Q9Y6N5" "" "Sulfide oxidation to sulfate" "1" "0" "1.582" "1.057" "1.241" "1.205" "1.277" "1.653" "1.097" "1.795" "1.202" "23.3" "36.8" "24.6" "28.9" "28.1" "29.7" "38.5" "25.5" "41.8" "28.0" "" "" "" "" "" "" "" "" "" "" "12.3" "20.4" "14.1" "13.3" "15.2" "16.5" "22.7" "13.9" "23.4" "28.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "866424040394030727" "False" "High" "IsMasterProtein" "Q15052" "Rho guanine nucleotide exchange factor 6 OS=Homo sapiens OX=9606 GN=ARHGEF6 PE=1 SV=2" "0.000" "False" "6.629" "3" "3" "3" "3" "776" "87.4" "6.05" "6.93" "3" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00169, Pf00307, Pf00621, Pf07653, Pf16523, Pf16614, Pf16615" "9459" "ENSG00000129675" "ARHGEF6" "A6NMW9; A8K6S7; B1AL37; hsa:9459; Q15052; Q15396; Q5JQ66; Q7Z3W1; Q86XH0" "Pancreatic adenocarcinoma pathway; Regulation of actin cytoskeleton" "G alpha (12/13) signalling events; G beta:gamma signalling through CDC42; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOU GTPase cycle; NRAGE signals death through JNK; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "9" "0" "1.039" "0.967" "1.119" "1.087" "0.973" "0.936" "0.435" "1.056" "7.259" "163.0" "169.4" "157.6" "182.4" "177.1" "158.6" "152.5" "70.9" "172.1" "1183.2" "" "" "" "" "" "" "" "" "" "" "86.3" "93.9" "90.2" "84.0" "95.8" "88.2" "89.8" "38.7" "96.5" "1183.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9173522146093415156" "False" "High" "IsMasterProtein" "Q9P0J7" "E3 ubiquitin-protein ligase KCMF1 OS=Homo sapiens OX=9606 GN=KCMF1 PE=1 SV=2" "0.000" "False" "6.628" "4" "2" "3" "2" "381" "41.9" "5.66" "8.52" "2" "cell-cell signaling" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00569, Pf05605" "56888" "ENSG00000176407" "KCMF1" "Q4ZG04; Q53SC7; Q9BWK2; Q9H8P5; Q9P0J7; Q9UFE8" "" "Neutrophil degranulation" "1" "0" "1.090" "1.080" "1.066" "1.174" "1.087" "1.021" "0.864" "0.978" "1.856" "357.4" "389.5" "385.8" "381.0" "419.5" "388.4" "364.9" "308.7" "349.7" "663.2" "" "" "" "" "" "" "" "" "" "" "189.2" "216.0" "221.0" "175.5" "227.0" "216.1" "214.8" "168.5" "196.2" "663.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2612054938348296953" "False" "High" "IsMasterProtein" "Q16595" "Frataxin, mitochondrial OS=Homo sapiens OX=9606 GN=FXN PE=1 SV=2" "0.000" "False" "6.618" "8" "1" "2" "1" "210" "23.1" "8.69" "7.57" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf01491" "2395" "ENSG00000165060" "FXN" "A8MXJ6; C9JJ89; hsa:2395; O15545; O95656; Q15294; Q16595; Q5VZ01" "Iron-sulfur cluster biogenesis" "Mitochondrial protein import; Mitochondrial iron-sulfur cluster biogenesis" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3476524128370901588" "False" "High" "IsMasterProtein" "P53634" "Dipeptidyl peptidase 1 OS=Homo sapiens OX=9606 GN=CTSC PE=1 SV=2" "0.000" "False" "6.613" "4" "2" "3" "2" "463" "51.8" "6.99" "9.04" "2" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00112, Pf08773" "1075" "ENSG00000109861" "CTSC" "A8K7V2; B5MDD5; hsa:1075; P53634; Q2HIY8; Q53G93; Q71E75; Q71E76; Q7M4N9; Q7Z3G7; Q7Z5U7; Q8WY99; Q8WYA7; Q8WYA8" "" "Neutrophil degranulation; MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER" "4" "0" "0.845" "0.923" "0.774" "0.766" "0.759" "0.866" "0.784" "0.719" "0.551" "175.8" "148.4" "162.3" "136.0" "134.6" "133.4" "152.3" "137.7" "126.5" "96.9" "" "" "" "" "" "" "" "" "" "" "93.1" "82.3" "93.0" "62.6" "72.8" "74.2" "89.6" "75.2" "70.9" "96.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-443661170883717287" "False" "High" "IsMasterProtein" "Q9NQ92" "Coordinator of PRMT5 and differentiation stimulator OS=Homo sapiens OX=9606 GN=COPRS PE=1 SV=3" "0.000" "False" "6.612" "14" "2" "2" "2" "184" "20.1" "4.18" "3.43" "2" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf15340" "55352" "ENSG00000172301" "COPRS" "A6NP14; E1P656; hsa:55352; Q96EF5; Q96P75; Q9NQ92" "NF1 copy number variation syndrome" "RMTs methylate histone arginines" "2" "0" "0.993" "1.039" "1.188" "0.999" "0.928" "1.030" "1.232" "0.939" "0.435" "106.0" "105.2" "110.1" "125.9" "105.9" "98.3" "109.1" "130.5" "99.5" "46.1" "" "" "" "" "" "" "" "" "" "" "56.1" "58.3" "63.1" "58.0" "57.3" "54.7" "64.2" "71.3" "55.8" "46.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6978617919950458725" "False" "High" "IsMasterProtein" "O43592" "Exportin-T OS=Homo sapiens OX=9606 GN=XPOT PE=1 SV=2" "0.000" "False" "6.612" "2" "2" "3" "2" "962" "109.9" "5.39" "6.68" "2" "transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03810, Pf08389, Pf19282" "11260" "ENSG00000184575" "XPOT" "A6NLH1; hsa:11260; O43592; O43784; Q8WUG2; Q9BVS7" "" "tRNA processing in the nucleus" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8486015732534254879" "False" "High" "IsMasterProtein" "Q7Z5W3" "RNA 5'-monophosphate methyltransferase OS=Homo sapiens OX=9606 GN=BCDIN3D PE=1 SV=1" "0.000" "False" "6.603" "5" "2" "2" "2" "292" "33.2" "6.70" "3.47" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06859" "144233" "ENSG00000186666" "BCDIN3D" "A8K829; hsa:144233; Q7Z5W3" "" "MicroRNA (miRNA) biogenesis" "1" "0" "1.148" "0.953" "1.070" "1.205" "0.952" "0.799" "0.926" "1.013" "0.795" "74.1" "85.0" "70.6" "79.2" "89.3" "70.5" "59.2" "68.6" "75.0" "58.9" "" "" "" "" "" "" "" "" "" "" "39.2" "47.2" "40.4" "36.5" "48.3" "39.2" "34.8" "37.4" "42.1" "58.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-710496043913301714" "False" "High" "IsMasterProtein" "Q15714" "TSC22 domain family protein 1 OS=Homo sapiens OX=9606 GN=TSC22D1 PE=1 SV=3" "0.000" "False" "6.602" "3" "3" "3" "2" "1073" "109.6" "5.64" "7.32" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01166" "8848" "ENSG00000102804" "TSC22D1" "A0A087X0H8; B3KRL7; B9EGI0; hsa:8848; O00666; Q15714; Q6AHX5; Q6IBU1; Q8NCN1; Q96JS5" "Ectoderm differentiation; Ectoderm differentiation" "" "2" "1" "0.967" "0.976" "0.944" "1.044" "0.971" "0.990" "1.031" "0.995" "0.860" "458.8" "443.6" "447.7" "432.9" "479.1" "445.5" "454.4" "472.9" "456.6" "394.6" "" "" "" "" "" "" "" "" "" "" "242.9" "246.0" "256.4" "199.4" "259.2" "247.8" "267.4" "258.2" "256.1" "394.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-90342498941342912" "False" "High" "IsMasterProtein" "Q8N8R5" "Mitochondrial protein C2orf69 OS=Homo sapiens OX=9606 GN=C2orf69 PE=1 SV=1" "0.000" "False" "6.602" "8" "3" "3" "3" "385" "43.4" "8.09" "4.51" "3" "other metabolic processes" "other membranes;mitochondrion" "" "Pf10561" "205327" "ENSG00000178074" "C2orf69" "hsa:205327; Q8N8R5; Q8NE30" "" "" "0" "0" "0.983" "1.080" "1.242" "1.139" "1.008" "1.211" "1.041" "1.000" "1.247" "85.5" "84.0" "92.3" "106.2" "97.3" "86.2" "103.6" "89.0" "85.5" "106.6" "" "" "" "" "" "" "" "" "" "" "45.3" "46.6" "52.9" "48.9" "52.7" "47.9" "60.9" "48.6" "48.0" "106.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5611096213630678464" "False" "High" "IsMasterProtein" "P11279" "Lysosome-associated membrane glycoprotein 1 OS=Homo sapiens OX=9606 GN=LAMP1 PE=1 SV=3" "0.000" "False" "6.592" "4" "2" "2" "2" "417" "44.9" "8.75" "6.15" "2" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01299, Pf21222" "3916" "ENSG00000185896" "LAMP1" "B4DWL3; hsa:3916; P11279; Q8WU33; Q96I40; Q9BRD2; Q9NP13" "" "Neutrophil degranulation" "1" "0" "0.985" "1.012" "1.030" "0.964" "0.845" "1.020" "0.982" "0.916" "0.524" "337.3" "332.3" "341.4" "347.3" "325.1" "285.1" "343.9" "331.4" "308.9" "176.6" "" "" "" "" "" "" "" "" "" "" "178.6" "184.3" "195.5" "159.9" "175.9" "158.6" "202.4" "180.9" "173.3" "176.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "484436176042567230" "False" "High" "IsMasterProtein" "P02686" "Myelin basic protein OS=Homo sapiens OX=9606 GN=MBP PE=1 SV=3" "0.000" "False" "6.588" "9" "3" "4" "3" "304" "33.1" "9.79" "9.19" "3" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf01669" "4155" "ENSG00000197971" "MBP" "A4FU54; A6NI84; A8MY86; A8MYL4; B3KY66; B7ZKS2; B7ZKS4; hsa:4155; P02686; Q15337; Q15338; Q15339; Q15340; Q59GX3; Q65ZS4; Q6AI64; Q6FH37; Q6FI04; Q6PK23" "Neural crest differentiation; Glial cell differentiation; Spinal cord injury; Interleukin-1 (IL-1) structural pathway; MECP2 and associated Rett syndrome; MAPK cascade; Complement system in neuronal development and plasticity; Opioid receptor pathways; Cell lineage map for neuronal differentiation" "EGR2 and SOX10-mediated initiation of Schwann cell myelination" "10" "0" "1.111" "1.138" "1.161" "1.038" "1.056" "1.070" "1.058" "0.955" "0.586" "398.0" "442.3" "453.0" "462.0" "413.2" "420.3" "425.9" "421.0" "380.2" "233.2" "" "" "" "" "" "" "" "" "" "" "210.8" "245.2" "259.4" "212.8" "223.5" "233.8" "250.7" "229.8" "213.3" "233.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2630091394541072843" "False" "High" "IsMasterProtein" "Q9P2Y5" "UV radiation resistance-associated gene protein OS=Homo sapiens OX=9606 GN=UVRAG PE=1 SV=1" "0.000" "False" "6.586" "3" "2" "2" "2" "699" "78.1" "8.29" "5.54" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf10186" "7405" "ENSG00000198382" "UVRAG" "B3KTC1; hsa:7405; O00392; Q9P2Y5" "Nanoparticle triggered autophagic cell death; Autophagy" "Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; SARS-CoV-2 modulates autophagy" "6" "0" "1.045" "0.930" "1.112" "1.094" "1.118" "1.127" "1.001" "1.040" "1.239" "158.9" "166.0" "147.7" "176.6" "173.9" "177.5" "179.0" "159.0" "165.3" "196.8" "" "" "" "" "" "" "" "" "" "" "84.1" "92.0" "84.6" "81.3" "94.1" "98.8" "105.3" "86.8" "92.7" "196.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7997158032231502372" "False" "High" "IsMasterProtein" "Q9Y6D9" "Mitotic spindle assembly checkpoint protein MAD1 OS=Homo sapiens OX=9606 GN=MAD1L1 PE=1 SV=2" "0.000" "False" "6.582" "3" "2" "2" "2" "718" "83.0" "5.92" "5.58" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05557" "8379" "ENSG00000002822" "MAD1L1" "B3KR41; hsa:8379; Q13312; Q75MI0; Q86UM4; Q9UNH0; Q9Y6D9" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; Pleural mesothelioma; CCL18 signaling pathway" "RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "10" "0" "1.389" "1.056" "1.077" "0.735" "0.941" "1.175" "0.526" "1.181" "6.517" "35.1" "48.8" "37.1" "37.8" "25.8" "33.0" "41.3" "18.5" "41.5" "228.9" "" "" "" "" "" "" "" "" "" "" "18.6" "27.1" "21.2" "17.4" "14.0" "18.4" "24.3" "10.1" "23.3" "228.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3327789120096563661" "False" "High" "IsMasterProtein" "Q9NR56" "Muscleblind-like protein 1 OS=Homo sapiens OX=9606 GN=MBNL1 PE=1 SV=2" "0.000" "False" "6.577" "5" "2" "2" "2" "388" "41.8" "8.90" "4.75" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608" "4154" "ENSG00000152601" "MBNL1" "E9PBW7; hsa:4154; O43311; O43797; Q86UV8; Q86UV9; Q96P92; Q96RE3; Q9NR56" "Adipogenesis" "" "1" "0" "1.047" "1.103" "1.123" "1.026" "1.087" "0.978" "1.085" "1.001" "0.828" "275.9" "288.9" "304.4" "309.9" "283.2" "299.9" "270.0" "299.5" "276.3" "228.4" "" "" "" "" "" "" "" "" "" "" "146.1" "160.2" "174.3" "142.7" "153.2" "166.8" "158.9" "163.5" "155.0" "228.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6142056770574276442" "False" "High" "IsMasterProtein" "Q96T58" "Msx2-interacting protein OS=Homo sapiens OX=9606 GN=SPEN PE=1 SV=1" "0.000" "False" "6.569" "1" "2" "2" "2" "3664" "402.0" "7.64" "5.65" "2" "signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf07744, Pf20808, Pf20809, Pf20810" "23013" "ENSG00000065526" "SPEN" "hsa:23013; Q96T58; Q9H9A8; Q9NWH5; Q9UQ01; Q9Y556" "Notch signaling pathway" "RHOBTB1 GTPase cycle" "2" "0" "1.470" "1.057" "1.324" "1.258" "1.144" "1.053" "1.275" "1.172" "1.142" "66.0" "97.1" "69.8" "87.4" "83.1" "75.5" "69.5" "84.2" "77.4" "75.4" "" "" "" "" "" "" "" "" "" "" "35.0" "53.8" "40.0" "40.2" "45.0" "42.0" "40.9" "46.0" "43.4" "75.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7763347901800507563" "False" "High" "IsMasterProtein" "Q9HB19" "Pleckstrin homology domain-containing family A member 2 OS=Homo sapiens OX=9606 GN=PLEKHA2 PE=1 SV=3" "0.000" "False" "6.556" "6" "3" "3" "3" "425" "47.2" "8.66" "4.44" "3" "other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00169" "59339" "ENSG00000169499" "PLEKHA2" "A8K727; hsa:59339; Q9HB19" "" "Synthesis of PIPs at the plasma membrane" "1" "0" "0.963" "1.016" "0.882" "1.060" "1.015" "0.871" "0.026" "0.885" "10.802" "110.6" "106.5" "112.4" "97.5" "117.2" "112.2" "96.3" "2.9" "97.8" "1194.5" "" "" "" "" "" "" "" "" "" "" "58.5" "59.1" "64.4" "44.9" "63.4" "62.4" "56.7" "1.6" "54.9" "1194.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8526861795692287608" "False" "High" "IsMasterProtein" "Q6PK04" "Coiled-coil domain-containing protein 137 OS=Homo sapiens OX=9606 GN=CCDC137 PE=1 SV=1" "0.000" "False" "6.549" "6" "2" "2" "2" "289" "33.2" "10.93" "5.76" "2" "" "nucleus;other cell component" "" "" "339230" "ENSG00000185298" "CCDC137" "hsa:339230; Q6PK04" "" "" "0" "0" "1.040" "1.047" "1.159" "1.216" "1.059" "1.251" "1.270" "1.275" "0.596" "162.6" "169.0" "170.1" "188.3" "197.7" "172.2" "203.4" "206.5" "207.3" "96.9" "" "" "" "" "" "" "" "" "" "" "86.1" "93.7" "97.4" "86.7" "106.9" "95.8" "119.7" "112.7" "116.3" "96.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3588161142439279914" "False" "High" "IsMasterProtein" "Q96RG2" "PAS domain-containing serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=PASK PE=1 SV=3" "0.000" "False" "6.544" "2" "2" "3" "2" "1323" "142.8" "4.86" "4.98" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf13426" "23178" "ENSG00000115687" "PASK" "G5E9F1; hsa:23178; Q05BE4; Q68DY3; Q6GSJ5; Q86XH6; Q96RG2; Q99763; Q9UFR7" "2q37 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3683679323439236664" "False" "High" "IsMasterProtein" "Q6IPR3" "tRNA wybutosine-synthesizing protein 3 homolog OS=Homo sapiens OX=9606 GN=TYW3 PE=1 SV=2" "0.000" "False" "6.540" "7" "2" "3" "2" "259" "29.8" "7.68" "5.53" "2" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "other molecular function" "Pf02676" "127253" "ENSG00000162623" "TYW3" "B4DSP9; E9PGR7; hsa:127253; Q5HYJ0; Q6IPR3; Q8N7L1" "" "Synthesis of wybutosine at G37 of tRNA(Phe)" "1" "0" "1.023" "1.007" "1.113" "1.027" "1.021" "0.990" "1.010" "0.866" "0.625" "630.5" "645.1" "635.1" "701.7" "647.6" "644.0" "624.3" "636.8" "546.3" "394.2" "" "" "" "" "" "" "" "" "" "" "333.9" "357.7" "363.7" "323.2" "350.4" "358.2" "367.4" "347.6" "306.4" "394.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7521593605618506386" "False" "High" "IsMasterProtein" "Q02556" "Interferon regulatory factor 8 OS=Homo sapiens OX=9606 GN=IRF8 PE=1 SV=2" "0.000" "False" "6.537" "7" "3" "3" "3" "426" "48.3" "6.77" "7.72" "3" "other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605, Pf10401" "3394" "ENSG00000140968" "IRF8" "A0AV82; hsa:3394; Q02556" "Vitamin D receptor pathway; Development of pulmonary dendritic cells and macrophage subsets; Extrafollicular and follicular B cell activation by SARS-CoV-2; 2q37 copy number variation syndrome; Type II interferon signaling" "Interferon gamma signaling; Interferon alpha/beta signaling" "7" "0" "1.117" "1.180" "1.088" "1.107" "1.080" "1.351" "1.136" "1.155" "2.445" "210.1" "234.6" "247.8" "228.5" "232.5" "227.0" "283.9" "238.7" "242.7" "513.6" "" "" "" "" "" "" "" "" "" "" "111.3" "130.1" "141.9" "105.2" "125.8" "126.3" "167.1" "130.3" "136.1" "513.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1941330484708974901" "False" "High" "IsMasterProtein" "P18621" "Large ribosomal subunit protein uL22 OS=Homo sapiens OX=9606 GN=RPL17 PE=1 SV=3" "0.000" "False" "6.518" "9" "2" "3" "2" "184" "21.4" "10.17" "10.56" "2" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf00237" "6139" "ENSG00000265681" "RPL17" "B2R4H3; B4E3C2; B5ME31; hsa:6139; J3QL51; P18621; Q3KQW2; Q6NZ54; Q7M4M5" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.942" "1.021" "1.005" "0.941" "1.009" "0.884" "0.909" "0.970" "0.806" "909.8" "857.0" "928.7" "914.3" "856.2" "918.3" "803.8" "827.1" "882.4" "733.3" "" "" "" "" "" "" "" "" "" "" "481.7" "475.1" "531.9" "421.1" "463.3" "510.8" "473.1" "451.5" "495.0" "733.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7927368921331951811" "False" "High" "IsMasterProtein" "Cont_O46375" "Transthyretin OS=Bos taurus OX=9913 GN=TTR PE=1 SV=1" "0.000" "True" "6.515" "10" "1" "1" "1" "147" "15.7" "6.30" "3.32" "1" "other metabolic processes;signal transduction" "non-structural extracellular" "signal transduction activity or receptor binding;other molecular function" "Pf00576" "102267525; 104980319; 109577967; 280948" "ENSBGRG00000022634; ENSBIXG00000008920; ENSBIXG00005017301; ENSBTAG00000010991" "TTR" "A0A4W2BU20; A0A6B0QTW8; A0A6P3GKP7; A0A6P5DX06; A0A8B9YDR1; bbis:104980319; biu:109577967; bom:102267525; bta:280948; O46375; Q3SZ91" "" "Neutrophil degranulation; Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision)" "3" "0" "1.139" "1.103" "1.178" "1.112" "1.241" "1.084" "1.222" "1.326" "0.688" "53.6" "61.0" "59.1" "63.1" "59.6" "66.5" "58.1" "65.5" "71.0" "36.9" "" "" "" "" "" "" "" "" "" "" "28.4" "33.8" "33.8" "29.1" "32.2" "37.0" "34.2" "35.7" "39.8" "36.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4607454407969117171" "False" "High" "IsMasterProtein" "A6NED2" "RCC1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RCCD1 PE=1 SV=1" "0.000" "False" "6.511" "3" "1" "1" "1" "376" "40.1" "5.27" "4.39" "1" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf00415" "91433" "ENSG00000166965" "RCCD1" "A6NED2; B2RTP9; hsa:91433; Q29RX6" "" "Protein hydroxylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4465081379876381336" "False" "High" "IsMasterProtein" "Q86U70" "LIM domain-binding protein 1 OS=Homo sapiens OX=9606 GN=LDB1 PE=1 SV=2" "0.000" "False" "6.510" "7" "3" "3" "3" "411" "46.5" "6.96" "5.28" "3" "cell adhesion;cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01803, Pf17916" "8861" "ENSG00000198728" "LDB1" "B4DUC4; hsa:8861; O75479; O96010; Q1EQX1; Q86U70; Q9UGM4" "" "Regulation of expression of SLITs and ROBOs; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Expression and translocation of olfactory receptors; Cardiogenesis" "4" "0" "0.951" "1.005" "0.982" "1.001" "0.995" "1.033" "1.091" "1.055" "0.746" "396.9" "377.6" "398.9" "389.8" "397.2" "395.1" "409.9" "433.1" "418.6" "296.0" "" "" "" "" "" "" "" "" "" "" "210.2" "209.4" "228.5" "179.5" "214.9" "219.8" "241.2" "236.4" "234.8" "296.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4223527727478599420" "False" "High" "IsMasterProtein" "Q9UBF8" "Phosphatidylinositol 4-kinase beta OS=Homo sapiens OX=9606 GN=PI4KB PE=1 SV=1" "0.000" "False" "6.502" "3" "2" "2" "2" "816" "91.3" "6.25" "4.65" "2" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00454, Pf21245" "5298" "ENSG00000143393" "PI4KB" "B4DGI2; hsa:5298; O15096; P78405; Q5VWB9; Q5VWC0; Q5VWC1; Q9BWR6; Q9UBF8" "" "Synthesis of PIPs at the Golgi membrane" "1" "0" "1.245" "1.048" "1.324" "1.361" "1.052" "1.277" "1.178" "0.953" "0.774" "149.7" "186.3" "156.9" "198.1" "203.7" "157.5" "191.2" "176.3" "142.7" "115.8" "" "" "" "" "" "" "" "" "" "" "79.3" "103.3" "89.8" "91.2" "110.2" "87.6" "112.5" "96.3" "80.1" "115.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5377867133964341860" "False" "High" "IsMasterProtein" "P02656" "Apolipoprotein C-III OS=Homo sapiens OX=9606 GN=APOC3 PE=1 SV=1" "0.000" "False" "6.498" "16" "1" "1" "1" "99" "10.8" "5.41" "3.51" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "non-structural extracellular;other cytoplasmic organelle" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf05778" "345" "ENSG00000110245" "APOC3" "hsa:345; P02656; Q08E83; Q6Q786" "PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Statin inhibition of cholesterol production; Cholesterol metabolism" "Retinoid metabolism and transport; Chylomicron assembly; Chylomicron remodeling; HDL remodeling" "9" "0" "1.492" "1.456" "1.381" "1.499" "1.175" "1.615" "1.678" "1.409" "1.061" "21.3" "31.8" "31.1" "29.5" "32.0" "25.1" "34.5" "35.8" "30.1" "22.7" "" "" "" "" "" "" "" "" "" "" "11.3" "17.6" "17.8" "13.6" "17.3" "14.0" "20.3" "19.5" "16.9" "22.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5219092479354345629" "False" "High" "IsMasterProtein" "O94855" "Protein transport protein Sec24D OS=Homo sapiens OX=9606 GN=SEC24D PE=1 SV=2" "0.000" "False" "6.496" "1" "1" "1" "1" "1032" "112.9" "7.25" "3.95" "1" "cell organization and biogenesis;transport;developmental processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "9871" "ENSG00000150961" "SEC24D" "hsa:9871; O94855; Q8IYI7" "Sterol regulatory element-binding proteins (SREBP) signaling" "MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "7" "0" "1.356" "1.022" "1.204" "1.028" "1.198" "1.130" "1.177" "1.191" "2.550" "80.5" "109.1" "82.3" "96.9" "82.7" "96.4" "90.9" "94.7" "95.8" "205.2" "" "" "" "" "" "" "" "" "" "" "42.6" "60.5" "47.1" "44.6" "44.7" "53.6" "53.5" "51.7" "53.8" "205.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5015349167503174310" "False" "High" "IsMasterProtein" "Q8NCC3" "Lysosomal phospholipase A and acyltransferase OS=Homo sapiens OX=9606 GN=PLA2G15 PE=1 SV=2" "0.000" "False" "6.487" "5" "2" "3" "2" "412" "46.6" "6.73" "9.41" "2" "other metabolic processes" "non-structural extracellular;other membranes;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02450" "23659" "ENSG00000103066" "PLA2G15" "B3KMF3; B4DUD1; hsa:23659; Q53GZ1; Q8NCC3; Q9NPQ6; Q9UG04; Q9Y2B3" "" "Hydrolysis of LPC" "1" "0" "1.229" "1.080" "0.989" "1.117" "0.797" "1.198" "1.140" "0.965" "0.723" "50.8" "62.4" "54.8" "50.2" "56.7" "40.5" "60.8" "57.9" "49.0" "36.7" "" "" "" "" "" "" "" "" "" "" "26.9" "34.6" "31.4" "23.1" "30.7" "22.5" "35.8" "31.6" "27.5" "36.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5208996323542288612" "False" "High" "IsMasterProtein" "Q8N5P1" "Zinc finger CCCH domain-containing protein 8 OS=Homo sapiens OX=9606 GN=ZC3H8 PE=1 SV=2" "0.000" "False" "6.484" "10" "3" "3" "3" "291" "33.6" "8.28" "7.10" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608, Pf18345" "84524" "ENSG00000144161" "ZC3H8" "hsa:84524; Q8N5P1; Q9BZ75" "2q13 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "0.925" "0.965" "0.939" "0.870" "0.814" "0.843" "0.876" "0.823" "0.401" "483.2" "447.0" "466.2" "453.9" "420.4" "393.5" "407.6" "423.4" "397.4" "193.9" "" "" "" "" "" "" "" "" "" "" "255.9" "247.8" "267.0" "209.1" "227.5" "218.9" "239.9" "231.1" "223.0" "193.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "882715983706929749" "False" "High" "IsMasterProtein" "Q9NZ08" "Endoplasmic reticulum aminopeptidase 1 OS=Homo sapiens OX=9606 GN=ERAP1 PE=1 SV=3" "0.000" "False" "6.480" "2" "2" "3" "2" "941" "107.2" "6.46" "7.05" "2" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01433, Pf11838, Pf17900" "51752" "ENSG00000164307" "ERAP1" "hsa:51752; O60278; Q6UWY6; Q8NEL4; Q8TAD0; Q9NZ08; Q9UHF8; Q9UKY2" "" "Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "1" "0" "1.051" "0.967" "0.959" "0.960" "0.821" "1.160" "0.968" "0.935" "2.600" "38.5" "40.4" "37.2" "36.9" "36.9" "31.6" "44.6" "37.2" "35.9" "100.0" "" "" "" "" "" "" "" "" "" "" "20.4" "22.4" "21.3" "17.0" "20.0" "17.6" "26.3" "20.3" "20.2" "100.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4970253198694079027" "False" "High" "IsMasterProtein" "Q96BW1" "Uracil phosphoribosyltransferase homolog OS=Homo sapiens OX=9606 GN=UPRT PE=1 SV=1" "0.000" "False" "6.474" "9" "3" "3" "3" "309" "33.8" "6.04" "3.04" "3" "other metabolic processes;transport;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf14681" "139596" "ENSG00000094841" "UPRT" "hsa:139596; Q5JRL1; Q5JRL3; Q68DN0; Q96BW1; Q96MW2" "Pyrimidine metabolism" "" "1" "0" "1.024" "0.911" "1.124" "1.007" "0.950" "1.099" "0.824" "0.957" "0.728" "207.6" "212.6" "189.2" "233.4" "209.0" "197.3" "228.0" "171.1" "198.7" "151.2" "" "" "" "" "" "" "" "" "" "" "109.9" "117.9" "108.3" "107.5" "113.1" "109.7" "134.2" "93.4" "111.5" "151.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1418350428187629844" "False" "High" "IsMasterProtein" "O43678" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 OS=Homo sapiens OX=9606 GN=NDUFA2 PE=1 SV=3" "0.000" "False" "6.473" "9" "1" "3" "1" "99" "10.9" "9.57" "8.04" "1" "cell organization and biogenesis;other metabolic processes;transport;developmental processes" "other membranes;mitochondrion" "transporter activity" "Pf05047" "4695" "ENSG00000131495" "NDUFA2" "D6RJD6; hsa:4695; O43678; Q6IAY8" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis; Mitochondrial protein degradation" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2857218708684993243" "False" "High" "IsMasterProtein" "Q9Y315" "Deoxyribose-phosphate aldolase OS=Homo sapiens OX=9606 GN=DERA PE=1 SV=2" "0.000" "False" "6.473" "10" "3" "7" "3" "318" "35.2" "8.94" "13.33" "3" "other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01791" "51071" "ENSG00000023697" "DERA" "hsa:51071; Q53HN9; Q6PHW2; Q9Y315" "Pentose phosphate pathway in senescent cells" "Neutrophil degranulation; Pentose phosphate pathway" "3" "0" "0.950" "0.834" "1.144" "1.158" "1.074" "1.068" "0.819" "0.991" "0.741" "60.5" "57.5" "50.5" "69.2" "70.1" "65.0" "64.6" "49.6" "59.9" "44.8" "" "" "" "" "" "" "" "" "" "" "32.0" "31.9" "28.9" "31.9" "37.9" "36.2" "38.0" "27.1" "33.6" "44.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4386101623326845776" "False" "High" "IsMasterProtein" "Q9Y4F5" "Centrosomal protein of 170 kDa protein B OS=Homo sapiens OX=9606 GN=CEP170B PE=1 SV=4" "0.000" "False" "6.473" "2" "3" "4" "1" "1589" "171.6" "6.84" "5.29" "3" "" "cytoskeleton;other cell component" "" "Pf00498, Pf15308" "283638" "ENSG00000099814" "CEP170B" "hsa:283638; Q2KHR7; Q86TI7; Q9Y4F5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "558828740565352174" "False" "High" "IsMasterProtein" "Q2VPK5" "Cytoplasmic tRNA 2-thiolation protein 2 OS=Homo sapiens OX=9606 GN=CTU2 PE=1 SV=1" "0.000" "False" "6.472" "3" "2" "3" "2" "515" "56.1" "6.32" "8.42" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf10288" "348180" "ENSG00000174177" "CTU2" "B2RXK0; hsa:348180; Q0P511; Q2VPK5; Q66K78; Q6P4C8; Q86SV4" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.022" "0.967" "1.007" "1.022" "1.052" "0.918" "0.914" "1.372" "1.279" "394.2" "402.7" "381.1" "396.8" "402.8" "414.5" "361.8" "360.4" "540.9" "504.0" "" "" "" "" "" "" "" "" "" "" "208.7" "223.3" "218.2" "182.7" "217.9" "230.6" "213.0" "196.7" "303.4" "504.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3246140782840633700" "False" "High" "IsMasterProtein" "Q96B01" "RAD51-associated protein 1 OS=Homo sapiens OX=9606 GN=RAD51AP1 PE=1 SV=1" "0.000" "False" "6.471" "5" "2" "2" "2" "352" "38.4" "9.11" "5.92" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf15696" "10635" "ENSG00000111247" "RAD51AP1" "A8K7D3; hsa:10635; O43403; Q7Z779; Q96B01" "" "Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Homologous DNA Pairing and Strand Exchange; Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2" "8" "0" "1.231" "1.051" "1.014" "0.979" "0.886" "0.812" "1.035" "0.909" "0.574" "319.5" "393.4" "335.7" "324.0" "312.7" "283.0" "259.4" "330.6" "290.5" "183.4" "" "" "" "" "" "" "" "" "" "" "169.2" "218.1" "192.3" "149.2" "169.2" "157.4" "152.7" "180.5" "163.0" "183.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2991774416485678648" "False" "High" "IsMasterProtein" "P51948" "CDK-activating kinase assembly factor MAT1 OS=Homo sapiens OX=9606 GN=MNAT1 PE=1 SV=1" "0.000" "False" "6.467" "6" "2" "2" "2" "309" "35.8" "6.09" "5.63" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus" "enzyme regulator activity;other molecular function" "Pf06391, Pf17121" "4331" "ENSG00000020426" "MNAT1" "G3V1U8; hsa:4331; P51948; Q15817; Q6ICQ7" "Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; RUNX1 regulates transcription of genes involved in differentiation of HSCs; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "38" "0" "1.357" "1.410" "1.367" "1.405" "1.285" "1.361" "1.249" "1.500" "1.345" "50.3" "68.2" "70.9" "68.7" "70.6" "64.6" "68.4" "62.8" "75.4" "67.6" "" "" "" "" "" "" "" "" "" "" "26.6" "37.8" "40.6" "31.6" "38.2" "35.9" "40.3" "34.3" "42.3" "67.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1553540605597619179" "False" "High" "IsMasterProtein" "P51965" "Ubiquitin-conjugating enzyme E2 E1 OS=Homo sapiens OX=9606 GN=UBE2E1 PE=1 SV=1" "0.000" "False" "6.464" "9" "1" "1" "1" "193" "21.4" "8.53" "4.09" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7324" "ENSG00000170142" "UBE2E1" "B2RBX4; C9J8K2; hsa:7324; K4DI90; P51965" "Photodynamic therapy-induced unfolded protein response; 7q11.23 copy number variation syndrome" "Separation of Sister Chromatids; Assembly of the pre-replicative complex; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; ISG15 antiviral mechanism; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "23" "0" "0.893" "1.263" "0.963" "1.472" "1.589" "1.194" "1.051" "2.116" "6.249" "26.3" "23.5" "33.2" "25.3" "38.7" "41.8" "31.4" "27.6" "55.6" "164.3" "" "" "" "" "" "" "" "" "" "" "13.9" "13.0" "19.0" "11.7" "20.9" "23.2" "18.5" "15.1" "31.2" "164.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4231086194268643311" "False" "High" "IsMasterProtein" "Q8N6R0" "eEF1A lysine and N-terminal methyltransferase OS=Homo sapiens OX=9606 GN=METTL13 PE=1 SV=1" "0.000" "False" "6.445" "2" "2" "3" "2" "699" "78.7" "6.73" "7.53" "2" "other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01564, Pf13847" "51603" "ENSG00000010165" "METTL13" "A6NFK0; A8K6S5; hsa:51603; O94940; Q53EZ6; Q5TGP9; Q5TGQ0; Q8N2P8; Q8N6R0; Q96J11; Q96SQ0; Q9Y2Z1; Q9Y3M6" "" "" "0" "0" "0.913" "0.993" "1.162" "1.132" "0.951" "1.137" "0.527" "0.904" "7.419" "87.5" "80.0" "86.9" "101.8" "99.1" "83.3" "99.5" "46.2" "79.1" "649.5" "" "" "" "" "" "" "" "" "" "" "46.4" "44.3" "49.8" "46.9" "53.6" "46.3" "58.6" "25.2" "44.4" "649.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5299456138050834551" "False" "High" "IsMasterProtein" "O00115" "Deoxyribonuclease-2-alpha OS=Homo sapiens OX=9606 GN=DNASE2 PE=1 SV=2" "0.000" "False" "6.442" "5" "2" "3" "2" "360" "39.6" "8.05" "8.72" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf03265" "1777" "ENSG00000105612" "DNASE2" "B2RD06; B7Z4K6; hsa:1777; O00115; O43910" "" "Lysosome Vesicle Biogenesis" "1" "0" "1.167" "1.311" "1.204" "0.956" "0.992" "0.822" "1.185" "1.150" "0.689" "248.4" "289.8" "325.6" "299.1" "237.6" "246.5" "204.2" "294.3" "285.6" "171.2" "" "" "" "" "" "" "" "" "" "" "131.5" "160.7" "186.5" "137.7" "128.5" "137.1" "120.2" "160.7" "160.2" "171.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4153058016593714536" "False" "High" "IsMasterProtein" "Q9UKT5" "F-box only protein 4 OS=Homo sapiens OX=9606 GN=FBXO4 PE=1 SV=2" "0.000" "False" "6.439" "5" "2" "2" "2" "387" "44.1" "6.16" "5.42" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00646" "26272" "ENSG00000151876" "FBXO4" "hsa:26272; Q68CU8; Q86VT8; Q9UK98; Q9UKT5" "" "Association of TriC/CCT with target proteins during biosynthesis; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "3" "0" "1.438" "1.177" "1.239" "1.090" "1.041" "1.104" "1.026" "1.212" "0.940" "64.0" "92.0" "75.4" "79.3" "69.8" "66.6" "70.7" "65.7" "77.6" "60.2" "" "" "" "" "" "" "" "" "" "" "33.9" "51.0" "43.2" "36.5" "37.7" "37.1" "41.6" "35.8" "43.5" "60.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3157784244312675539" "False" "High" "IsMasterProtein" "Q9UKD2" "mRNA turnover protein 4 homolog OS=Homo sapiens OX=9606 GN=MRTO4 PE=1 SV=2" "0.000" "False" "6.423" "8" "2" "2" "2" "239" "27.5" "8.29" "7.12" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00466, Pf17777" "51154" "ENSG00000053372" "MRTO4" "B3KNB3; hsa:51154; Q5TG55; Q96SS6; Q9BPV9; Q9UKD2" "" "" "0" "0" "1.066" "1.045" "1.076" "1.126" "1.095" "1.118" "1.044" "1.090" "1.389" "388.9" "414.6" "406.6" "418.6" "437.8" "426.0" "434.7" "405.9" "423.8" "540.2" "" "" "" "" "" "" "" "" "" "" "205.9" "229.9" "232.9" "192.8" "236.9" "237.0" "255.8" "221.6" "237.7" "540.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2811678325838740313" "False" "High" "IsMasterProtein" "Q9NXW9" "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 OS=Homo sapiens OX=9606 GN=ALKBH4 PE=1 SV=1" "0.000" "False" "6.419" "7" "2" "2" "2" "302" "33.8" "6.67" "3.03" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "54784" "ENSG00000160993" "ALKBH4" "hsa:54784; Q53H92; Q9H6A4; Q9NXW9" "" "" "0" "0" "1.226" "1.104" "1.139" "1.160" "1.124" "1.279" "1.062" "1.009" "1.500" "64.4" "79.0" "71.1" "73.4" "74.7" "72.4" "82.4" "68.4" "65.0" "96.6" "" "" "" "" "" "" "" "" "" "" "34.1" "43.8" "40.7" "33.8" "40.4" "40.3" "48.5" "37.3" "36.4" "96.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9188891296985920952" "False" "High" "IsMasterProtein" "P31483" "Cytotoxic granule associated RNA binding protein TIA1 OS=Homo sapiens OX=9606 GN=TIA1 PE=1 SV=3" "0.000" "False" "6.415" "5" "2" "3" "1" "386" "42.9" "7.74" "10.75" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "7072" "ENSG00000116001" "TIA1" "hsa:7072; P31483; Q53SS9; Q96B58" "" "FGFR2 alternative splicing" "1" "0" "0.968" "0.962" "0.739" "0.927" "1.028" "0.844" "0.865" "0.993" "0.484" "954.2" "923.8" "917.5" "705.4" "885.0" "980.5" "805.0" "825.0" "947.4" "462.2" "" "" "" "" "" "" "" "" "" "" "505.3" "512.2" "525.5" "324.9" "478.8" "545.4" "473.8" "450.3" "531.5" "462.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7103280702382610433" "False" "High" "IsMasterProtein" "Q8IX90" "Spindle and kinetochore-associated protein 3 OS=Homo sapiens OX=9606 GN=SKA3 PE=1 SV=2" "0.000" "False" "6.415" "2" "1" "1" "1" "412" "46.3" "5.11" "3.68" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "" "221150" "ENSG00000165480" "SKA3" "A2A330; A2A331; B2RBY2; hsa:221150; Q5VZV5; Q86WR2; Q8IX90; Q8NBG1; Q96D22" "" "" "0" "0" "0.918" "0.890" "1.023" "1.082" "0.915" "0.992" "0.712" "0.885" "5.109" "73.7" "67.7" "65.6" "75.4" "79.7" "67.4" "73.1" "52.5" "65.2" "376.4" "" "" "" "" "" "" "" "" "" "" "39.0" "37.5" "37.5" "34.7" "43.1" "37.5" "43.0" "28.6" "36.6" "376.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6321776130452368548" "False" "High" "IsMasterProtein" "Q9H7Z6" "Histone acetyltransferase KAT8 OS=Homo sapiens OX=9606 GN=KAT8 PE=1 SV=2" "0.000" "False" "6.399" "2" "1" "1" "1" "458" "52.4" "8.27" "4.33" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01853, Pf11717, Pf17772" "84148" "ENSG00000103510" "KAT8" "A8K4Z1; G5E9P2; hsa:84148; Q659G0; Q7LC17; Q8IY59; Q8WYB4; Q8WZ14; Q9H7Z6; Q9HAC5; Q9NR35" "" "HATs acetylate histones; Formation of WDR5-containing histone-modifying complexes" "2" "0" "0.887" "0.730" "1.003" "1.005" "0.992" "1.018" "0.882" "1.178" "2.014" "80.2" "71.2" "58.6" "80.5" "80.7" "79.6" "81.7" "70.8" "94.5" "161.6" "" "" "" "" "" "" "" "" "" "" "42.5" "39.5" "33.5" "37.1" "43.6" "44.3" "48.1" "38.6" "53.0" "161.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4336688759083416299" "False" "High" "IsMasterProtein" "Q15813" "Tubulin-specific chaperone E OS=Homo sapiens OX=9606 GN=TBCE PE=1 SV=1" "0.000" "False" "6.383" "3" "2" "2" "2" "527" "59.3" "6.76" "6.53" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf01302, Pf14560" "6905" "ENSG00000284770" "TBCE" "A8K8C2; B7Z3P1; Q15813" "" "Post-chaperonin tubulin folding pathway" "1" "0" "0.942" "0.981" "1.046" "0.935" "1.003" "1.006" "0.347" "1.005" "6.507" "206.1" "194.2" "202.1" "215.6" "192.8" "206.8" "207.4" "71.6" "207.1" "1341.1" "" "" "" "" "" "" "" "" "" "" "109.1" "107.7" "115.7" "99.3" "104.3" "115.0" "122.0" "39.1" "116.2" "1341.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5982542769367786087" "False" "High" "IsMasterProtein" "O75116" "Rho-associated protein kinase 2 OS=Homo sapiens OX=9606 GN=ROCK2 PE=1 SV=4" "0.000" "False" "6.382" "2" "3" "3" "2" "1388" "160.8" "6.02" "7.20" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf08912" "9475" "ENSG00000134318" "ROCK2" "hsa:9475; O75116; Q53QZ0; Q53SJ7; Q9UQN5" "Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Pathogenic Escherichia coli infection; Spinal cord injury; Focal adhesion; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Wnt signaling; Airway smooth muscle cell contraction; Regulation of actin cytoskeleton; GDNF signaling; G13 signaling pathway" "Potential therapeutics for SARS; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHOB GTPase cycle; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHOBTB1 GTPase cycle; RHOH GTPase cycle" "27" "0" "0.845" "0.875" "1.112" "0.960" "0.948" "1.084" "0.679" "0.955" "3.453" "156.9" "132.6" "137.3" "174.5" "150.7" "148.7" "170.0" "106.5" "149.8" "541.8" "" "" "" "" "" "" "" "" "" "" "83.1" "73.5" "78.6" "80.4" "81.5" "82.7" "100.1" "58.1" "84.0" "541.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6373190460563601224" "False" "High" "IsMasterProtein" "Q7L014" "Probable ATP-dependent RNA helicase DDX46 OS=Homo sapiens OX=9606 GN=DDX46 PE=1 SV=2" "0.000" "False" "6.374" "3" "3" "3" "3" "1031" "117.3" "9.29" "7.05" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "other membranes;nucleus" "other molecular function" "Pf00270, Pf00271" "9879" "ENSG00000145833" "DDX46" "hsa:9879; O94894; Q7L014; Q96EI0; Q9Y658" "" "mRNA Splicing - Major Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4518477556068487686" "False" "High" "IsMasterProtein" "P30046" "D-dopachrome decarboxylase OS=Homo sapiens OX=9606 GN=DDT PE=1 SV=3" "0.000" "False" "6.374" "13" "2" "3" "2" "118" "12.7" "7.30" "8.69" "2" "other metabolic processes;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01187" "1652" "ENSG00000099977; ENSG00000275003" "DDT" "B7Z522; hsa:1652; O00774; O60787; P30046; Q13534" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5797798922783167285" "False" "High" "IsMasterProtein" "Q2TAY7" "WD40 repeat-containing protein SMU1 OS=Homo sapiens OX=9606 GN=SMU1 PE=1 SV=2" "0.000" "False" "6.364" "5" "3" "4" "3" "513" "57.5" "7.18" "9.84" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00400, Pf17814" "55234" "ENSG00000122692" "SMU1" "B4E3L0; hsa:55234; Q2TAY7; Q9BU59; Q9HA96; Q9NVD1" "" "mRNA Splicing - Major Pathway" "1" "0" "0.925" "1.016" "0.909" "0.993" "1.024" "0.977" "1.029" "1.191" "1.570" "218.7" "202.3" "222.3" "198.9" "217.2" "224.0" "213.8" "225.1" "260.5" "343.4" "" "" "" "" "" "" "" "" "" "" "115.8" "112.1" "127.3" "91.6" "117.5" "124.6" "125.8" "122.9" "146.2" "343.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8494734003636031426" "False" "High" "IsMasterProtein" "Q8N2Z9" "Centromere protein S OS=Homo sapiens OX=9606 GN=CENPS PE=1 SV=1" "0.000" "False" "6.357" "14" "2" "2" "2" "138" "15.9" "6.05" "2.66" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15630" "100526739; 378708" "ENSG00000175279" "CENPS" "hsa:100526739; hsa:378708; Q8N2Z9; Q8NFE5; Q8NFG5" "DNA repair pathways, full network" "PKR-mediated signaling; Fanconi Anemia Pathway; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere" "10" "0" "0.978" "1.034" "1.107" "1.084" "0.948" "1.037" "1.040" "1.174" "0.770" "82.5" "80.7" "85.3" "91.3" "89.4" "78.2" "85.5" "85.8" "96.8" "63.5" "" "" "" "" "" "" "" "" "" "" "43.7" "44.7" "48.8" "42.0" "48.4" "43.5" "50.3" "46.8" "54.3" "63.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5993686438301718268" "False" "High" "IsMasterProtein" "Q96P11" "28S rRNA (cytosine-C(5))-methyltransferase OS=Homo sapiens OX=9606 GN=NSUN5 PE=1 SV=2" "0.000" "False" "6.356" "5" "2" "2" "2" "429" "46.7" "8.62" "5.18" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus" "other molecular function" "Pf01189, Pf21148, Pf21153" "55695" "ENSG00000130305" "NSUN5" "B3KX04; B4DP79; G3V0G9; hsa:55695; Q6ZUI8; Q96HT9; Q96P11; Q9NW70" "" "" "0" "0" "1.143" "1.085" "1.111" "1.133" "1.189" "1.148" "1.056" "1.117" "3.011" "85.5" "97.7" "92.8" "95.0" "96.9" "101.7" "98.1" "90.3" "95.5" "257.4" "" "" "" "" "" "" "" "" "" "" "45.3" "54.2" "53.1" "43.8" "52.4" "56.6" "57.7" "49.3" "53.6" "257.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4597913287802266182" "False" "High" "IsMasterProtein" "O60921" "Checkpoint protein HUS1 OS=Homo sapiens OX=9606 GN=HUS1 PE=1 SV=1" "0.000" "False" "6.356" "6" "1" "1" "1" "280" "31.7" "6.84" "3.38" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04005" "3364" "ENSG00000136273" "HUS1" "B4DFI9; hsa:3364; O60921" "ATR signaling" "Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "8" "0" "0.997" "1.028" "1.290" "1.068" "0.976" "1.063" "1.008" "1.007" "0.787" "27.9" "27.8" "28.7" "36.0" "29.8" "27.2" "29.6" "28.1" "28.1" "22.0" "" "" "" "" "" "" "" "" "" "" "14.8" "15.4" "16.4" "16.6" "16.1" "15.1" "17.4" "15.3" "15.8" "22.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4257899417113298170" "False" "High" "IsMasterProtein" "P78316" "Nucleolar protein 14 OS=Homo sapiens OX=9606 GN=NOP14 PE=1 SV=3" "0.000" "False" "6.321" "2" "2" "2" "2" "857" "97.6" "7.58" "5.62" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04147" "8602" "ENSG00000087269" "NOP14" "D3DVR6; hsa:8602; P78316; Q7LGI5; Q7Z6K0; Q8TBR6" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "0.967" "0.886" "1.186" "1.135" "0.986" "2.290" "2.271" "2.085" "1.549" "159.9" "154.7" "141.8" "189.7" "181.5" "157.7" "366.2" "363.2" "333.4" "247.8" "" "" "" "" "" "" "" "" "" "" "84.7" "85.8" "81.2" "87.4" "98.2" "87.7" "215.5" "198.3" "187.0" "247.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2129800861400375686" "False" "High" "IsMasterProtein" "O60220" "Mitochondrial import inner membrane translocase subunit Tim8 A OS=Homo sapiens OX=9606 GN=TIMM8A PE=1 SV=1" "0.000" "False" "6.320" "11" "1" "1" "1" "97" "11.0" "5.16" "3.43" "1" "cell organization and biogenesis;transport;developmental processes" "other membranes;mitochondrion" "other molecular function" "Pf02953" "1678" "ENSG00000126953" "TIMM8A" "B2R5A6; O60220; Q6IRW6" "" "Mitochondrial protein import" "1" "0" "1.162" "1.258" "1.136" "1.184" "1.165" "0.960" "1.109" "1.149" "0.609" "136.5" "158.6" "171.6" "155.1" "161.5" "158.9" "131.1" "151.3" "156.7" "83.1" "" "" "" "" "" "" "" "" "" "" "72.3" "87.9" "98.3" "71.4" "87.4" "88.4" "77.1" "82.6" "87.9" "83.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5438538710980627953" "False" "High" "IsMasterProtein" "Q9H2C0" "Gigaxonin OS=Homo sapiens OX=9606 GN=GAN PE=1 SV=1" "0.000" "False" "6.312" "3" "2" "3" "2" "597" "67.6" "5.85" "8.82" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "" "Pf00651, Pf01344, Pf07707" "8139" "ENSG00000261609" "GAN" "hsa:8139; Q9H2C0" "" "Neddylation; Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "1.014" "0.974" "1.056" "1.090" "1.269" "1.194" "1.154" "1.184" "0.964" "426.0" "432.2" "415.0" "449.7" "464.4" "540.8" "508.8" "491.9" "504.4" "410.6" "" "" "" "" "" "" "" "" "" "" "225.6" "239.6" "237.7" "207.1" "251.3" "300.8" "299.4" "268.5" "283.0" "410.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8924414405991965446" "False" "High" "IsMasterProtein" "P98179" "RNA-binding protein 3 OS=Homo sapiens OX=9606 GN=RBM3 PE=1 SV=1" "0.000" "False" "6.311" "15" "3" "7" "3" "157" "17.2" "8.91" "19.23" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity" "Pf00076" "5935" "ENSG00000102317" "RBM3" "hsa:5935; P98179" "" "" "0" "0" "0.978" "1.152" "0.957" "0.909" "0.981" "0.858" "0.992" "0.938" "0.615" "1015.8" "993.1" "1170.2" "972.4" "923.3" "996.4" "871.6" "1007.5" "952.5" "624.9" "" "" "" "" "" "" "" "" "" "" "537.9" "550.6" "670.2" "447.8" "499.5" "554.2" "513.0" "550.0" "534.3" "624.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-448736336253279631" "False" "High" "IsMasterProtein" "Q9Y2H0" "Disks large-associated protein 4 OS=Homo sapiens OX=9606 GN=DLGAP4 PE=1 SV=3" "0.000" "False" "6.309" "1" "1" "2" "1" "992" "107.9" "7.08" "4.73" "1" "other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf03359" "22839" "ENSG00000080845" "DLGAP4" "E1P5T5; hsa:22839; Q5QPG4; Q5T2Y4; Q5T2Y5; Q9H137; Q9H138; Q9H1L7; Q9Y2H0" "" "Neurexins and neuroligins" "1" "0" "1.152" "1.223" "1.361" "1.250" "0.918" "1.104" "1.301" "1.386" "0.462" "34.1" "39.3" "41.7" "46.4" "42.6" "31.3" "37.7" "44.4" "47.3" "15.8" "" "" "" "" "" "" "" "" "" "" "18.1" "21.8" "23.9" "21.4" "23.1" "17.4" "22.2" "24.2" "26.5" "15.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4812205563963537221" "False" "High" "IsMasterProtein" "Q9BSH5" "Haloacid dehalogenase-like hydrolase domain-containing protein 3 OS=Homo sapiens OX=9606 GN=HDHD3 PE=1 SV=1" "0.000" "False" "6.301" "6" "2" "2" "2" "251" "28.0" "6.71" "6.26" "2" "" "nucleus;other cell component" "" "Pf00702" "81932" "ENSG00000119431" "HDHD3" "B2RD47; hsa:81932; Q9BSH5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9040349963704556613" "False" "High" "IsMasterProtein" "P30154" "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform OS=Homo sapiens OX=9606 GN=PPP2R1B PE=1 SV=3" "0.000" "False" "6.297" "3" "3" "6" "1" "601" "66.2" "4.94" "18.12" "3" "other biological processes" "other membranes;other cell component" "enzyme regulator activity" "Pf02985, Pf13646" "5519" "ENSG00000137713" "PPP2R1B" "A8MY67; B0YJ69; B4DGQ6; B4DK91; B4DWW5; F8W8G1; hsa:5519; O75620; P30154; Q8NHV8" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Netrin-UNC5B signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; DARPP-32 events; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; PKR-mediated signaling; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of TP53 Degradation; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Cyclin A/B1/B2 associated events during G2/M transition; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "40" "0" "1.020" "1.073" "1.206" "0.862" "0.908" "0.940" "0.863" "0.958" "4.232" "110.8" "113.0" "118.9" "133.6" "95.5" "100.6" "104.2" "95.6" "106.2" "468.8" "" "" "" "" "" "" "" "" "" "" "58.7" "62.7" "68.1" "61.5" "51.7" "55.9" "61.3" "52.2" "59.6" "468.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "945913478307562709" "False" "High" "IsMasterProtein" "Q9Y2Q9" "Small ribosomal subunit protein bS1m OS=Homo sapiens OX=9606 GN=MRPS28 PE=1 SV=1" "0.000" "False" "6.291" "5" "1" "2" "1" "187" "20.8" "9.10" "5.56" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf10246" "28957" "ENSG00000147586" "MRPS28" "B2RDZ7; hsa:28957; Q96Q21; Q9Y2Q9" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1612491288449717862" "False" "High" "IsMasterProtein" "Q13155" "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 OS=Homo sapiens OX=9606 GN=AIMP2 PE=1 SV=2" "0.000" "False" "6.283" "8" "2" "4" "2" "320" "35.3" "8.22" "11.34" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00043, Pf16780, Pf18569" "7965" "ENSG00000106305" "AIMP2" "F8W950; hsa:7965; Q13155; Q75MR1; Q96CZ5; Q9P1L2" "Osteoclast signaling; Transcriptional activation by NRF2 in response to phytochemicals; NRF2-ARE regulation" "Cytosolic tRNA aminoacylation; Selenoamino acid metabolism" "5" "0" "1.072" "1.175" "1.173" "1.174" "1.138" "1.041" "0.670" "1.070" "5.195" "213.5" "229.0" "250.9" "250.5" "250.7" "242.9" "222.3" "143.1" "228.5" "1109.2" "" "" "" "" "" "" "" "" "" "" "113.1" "127.0" "143.7" "115.3" "135.6" "135.1" "130.9" "78.1" "128.2" "1109.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9084351700158867792" "False" "High" "IsMasterProtein" "Q9HD33" "Large ribosomal subunit protein uL29m OS=Homo sapiens OX=9606 GN=MRPL47 PE=1 SV=2" "0.000" "False" "6.267" "7" "2" "3" "2" "250" "29.4" "10.37" "2.16" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf06984" "57129" "ENSG00000136522" "MRPL47" "hsa:57129; Q6XRG1; Q8N5D1; Q9HD33" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.098" "1.260" "1.265" "1.224" "1.015" "1.133" "0.973" "0.912" "1.277" "138.5" "152.1" "174.4" "175.1" "169.5" "140.6" "156.9" "134.8" "126.3" "176.8" "" "" "" "" "" "" "" "" "" "" "73.3" "84.3" "99.9" "80.6" "91.7" "78.2" "92.4" "73.6" "70.9" "176.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5291509197618805102" "False" "High" "IsMasterProtein" "Cont_Q3SZ57" "Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1" "0.000" "True" "6.259" "4" "3" "3" "2" "610" "68.5" "6.29" "6.99" "3" "other metabolic processes;developmental processes;signal transduction" "non-structural extracellular;other cell component" "other molecular function" "Pf00273" "506011" "ENSBIXG00000005150; ENSBTAG00000017131" "AFP" "A0A4W2DDK5; bta:506011; Q3SZ57" "" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "2" "0" "0.963" "1.062" "0.919" "1.019" "1.146" "0.968" "1.113" "1.184" "0.791" "202.9" "195.3" "215.5" "186.4" "206.7" "232.6" "196.5" "225.9" "240.2" "160.6" "" "" "" "" "" "" "" "" "" "" "107.4" "108.3" "123.4" "85.9" "111.8" "129.4" "115.6" "123.3" "134.7" "160.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5796509123597455273" "False" "High" "IsMasterProtein" "Q14558" "Phosphoribosyl pyrophosphate synthase-associated protein 1 OS=Homo sapiens OX=9606 GN=PRPSAP1 PE=1 SV=2" "0.000" "False" "6.252" "10" "4" "4" "3" "356" "39.4" "7.20" "5.29" "4" "other metabolic processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf13793, Pf14572" "5635" "ENSG00000161542" "PRPSAP1" "B2R6M4; hsa:5635; Q14558; Q96H06" "" "" "0" "0" "1.135" "1.022" "1.116" "1.342" "1.213" "1.228" "1.261" "1.194" "0.693" "300.0" "340.5" "306.7" "334.8" "402.5" "363.9" "368.4" "378.3" "358.2" "207.8" "" "" "" "" "" "" "" "" "" "" "158.9" "188.8" "175.6" "154.2" "217.8" "202.4" "216.8" "206.5" "200.9" "207.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8388783144784420231" "False" "High" "IsMasterProtein" "P82930" "Small ribosomal subunit protein mS34 OS=Homo sapiens OX=9606 GN=MRPS34 PE=1 SV=2" "0.000" "False" "6.248" "10" "3" "3" "3" "218" "25.6" "9.98" "4.50" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf16053" "65993" "ENSG00000074071" "MRPS34" "hsa:65993; P82930; Q9BVI7" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7201160367223049830" "False" "High" "IsMasterProtein" "Cont_Q3MHN5" "Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1" "0.000" "True" "6.235" "3" "2" "2" "2" "474" "53.3" "5.52" "5.55" "2" "transport" "non-structural extracellular;other cell component" "transporter activity;cytoskeletal activity;other molecular function" "Pf00273, Pf09164" "530076" "" "GC" "bta:530076; Q3MHN5" "" "" "0" "0" "1.154" "1.103" "1.071" "1.433" "1.505" "1.228" "1.404" "1.559" "0.672" "128.2" "147.9" "141.4" "137.4" "183.7" "192.9" "157.5" "180.0" "199.9" "86.2" "" "" "" "" "" "" "" "" "" "" "67.9" "82.0" "81.0" "63.3" "99.4" "107.3" "92.7" "98.3" "112.1" "86.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5373690399274413822" "False" "High" "IsMasterProtein" "Q8N543" "Prolyl 3-hydroxylase OGFOD1 OS=Homo sapiens OX=9606 GN=OGFOD1 PE=1 SV=1" "0.000" "False" "6.226" "4" "3" "3" "3" "542" "63.2" "5.11" "7.92" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf10637, Pf13661" "55239" "ENSG00000087263" "OGFOD1" "H3BUQ2; hsa:55239; Q8N543; Q9H7U5; Q9H9J9; Q9HA87; Q9HCG0; Q9NVB6" "" "Protein hydroxylation" "1" "0" "0.683" "0.664" "0.951" "0.906" "0.892" "1.060" "0.795" "0.805" "0.851" "54.6" "37.3" "36.3" "52.0" "49.5" "48.7" "57.9" "43.4" "44.0" "46.5" "" "" "" "" "" "" "" "" "" "" "28.9" "20.7" "20.8" "23.9" "26.8" "27.1" "34.1" "23.7" "24.7" "46.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3464311242002607672" "False" "High" "IsMasterProtein" "P86790" "Vacuolar fusion protein CCZ1 homolog B OS=Homo sapiens OX=9606 GN=CCZ1B PE=1 SV=1" "0.000" "False" "6.215" "4" "2" "2" "2" "482" "55.8" "6.48" "3.76" "2" "transport" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf19031, Pf19032, Pf19033" "221960; 51622" "ENSG00000146574" "CCZ1B" "A2RU45; hsa:221960; hsa:51622; O95766; P86790; Q9UG65; Q9Y359" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6883226900925947322" "False" "High" "IsMasterProtein" "Q9BW83" "Intraflagellar transport protein 27 homolog OS=Homo sapiens OX=9606 GN=IFT27 PE=1 SV=1" "0.000" "False" "6.211" "9" "2" "3" "2" "186" "20.5" "5.41" "8.22" "2" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00071" "11020" "ENSG00000100360" "IFT27" "hsa:11020; O60897; Q9BW83" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies; GDNF/RET signaling axis; Alstrom syndrome; Bardet-Biedl syndrome" "Intraflagellar transport" "8" "0" "1.069" "0.976" "0.971" "1.014" "1.038" "1.022" "0.887" "1.002" "0.578" "337.2" "360.6" "329.1" "327.6" "342.0" "350.0" "344.6" "299.2" "337.9" "195.1" "" "" "" "" "" "" "" "" "" "" "178.6" "199.9" "188.5" "150.8" "185.0" "194.7" "202.8" "163.3" "189.6" "195.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "961314597478386434" "False" "High" "IsMasterProtein" "P57740" "Nuclear pore complex protein Nup107 OS=Homo sapiens OX=9606 GN=NUP107 PE=1 SV=1" "0.000" "False" "6.207" "2" "2" "2" "2" "925" "106.3" "5.43" "4.63" "2" "cell organization and biogenesis;other metabolic processes;transport;developmental processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf04121" "57122" "ENSG00000111581" "NUP107" "B4DZ67; hsa:57122; P57740; Q6PJE1" "Gastric cancer network 1; Primary ovarian insufficiency" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; SUMOylation of RNA binding proteins; Regulation of HSF1-mediated heat shock response; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "37" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3728877322360888626" "False" "High" "IsMasterProtein" "P62854" "Small ribosomal subunit protein eS26 OS=Homo sapiens OX=9606 GN=RPS26 PE=1 SV=3" "0.000" "False" "6.204" "14" "2" "2" "2" "115" "13.0" "11.00" "5.79" "2" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01283" "6231" "ENSG00000197728" "RPS26" "hsa:6231; P02383; P62854; P70394; Q06722; Q3MHD8; Q6IRY4" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Peptide chain elongation; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.001" "1.028" "1.160" "1.050" "1.094" "0.980" "1.009" "0.931" "1.050" "286.4" "286.7" "294.4" "332.3" "300.8" "313.3" "280.6" "288.8" "266.7" "300.6" "" "" "" "" "" "" "" "" "" "" "151.6" "159.0" "168.6" "153.0" "162.7" "174.3" "165.2" "157.7" "149.6" "300.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8105981666538771075" "False" "High" "IsMasterProtein" "P80297" "Metallothionein-1X OS=Homo sapiens OX=9606 GN=MT1X PE=1 SV=1" "0.000" "False" "6.194" "13" "1" "2" "1" "61" "6.1" "7.96" "4.36" "1" "stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00131" "4501" "ENSG00000187193" "MT1X" "A8MUC7; hsa:4501; P80297" "Copper homeostasis; Zinc homeostasis; Oxidative stress response" "Metallothioneins bind metals" "4" "0" "1.063" "1.120" "1.182" "0.939" "0.917" "0.993" "0.849" "0.827" "0.501" "165.0" "175.4" "184.7" "195.0" "154.9" "151.2" "163.9" "140.0" "136.5" "82.6" "" "" "" "" "" "" "" "" "" "" "87.3" "97.2" "105.8" "89.8" "83.8" "84.1" "96.4" "76.4" "76.6" "82.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6665456693960719485" "False" "High" "IsMasterProtein" "Q86V88" "Magnesium-dependent phosphatase 1 OS=Homo sapiens OX=9606 GN=MDP1 PE=1 SV=1" "0.000" "False" "6.181" "7" "1" "1" "1" "176" "20.1" "6.39" "3.62" "1" "" "" "other molecular function" "Pf12689" "145553" "ENSG00000213920; ENSG00000285200" "MDP1" "hsa:145553; Q86V88; Q86Y84; Q8NAD9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-374289036912732411" "False" "High" "IsMasterProtein" "Q15042" "Rab3 GTPase-activating protein catalytic subunit OS=Homo sapiens OX=9606 GN=RAB3GAP1 PE=1 SV=3" "0.000" "False" "6.179" "2" "2" "3" "2" "981" "110.5" "5.55" "5.17" "2" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf13890, Pf19533" "22930" "ENSG00000115839" "RAB3GAP1" "A6H8Z3; C9J837; hsa:22930; Q15042; Q659F5; Q8TBB4" "" "RAB GEFs exchange GTP for GDP on RABs; COPI-independent Golgi-to-ER retrograde traffic" "2" "0" "1.348" "1.105" "1.532" "1.250" "1.175" "1.159" "0.471" "1.090" "7.589" "115.2" "155.3" "127.4" "176.4" "144.0" "135.4" "133.5" "54.3" "125.5" "874.3" "" "" "" "" "" "" "" "" "" "" "61.0" "86.1" "72.9" "81.3" "77.9" "75.3" "78.6" "29.6" "70.4" "874.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5841636671217917151" "False" "High" "IsMasterProtein" "Q5JTJ3" "Cytochrome c oxidase assembly factor 6 homolog OS=Homo sapiens OX=9606 GN=COA6 PE=1 SV=1" "0.000" "False" "6.177" "11" "1" "1" "1" "125" "14.1" "8.25" "4.34" "1" "cell organization and biogenesis;other metabolic processes" "plasma membrane;other membranes;mitochondrion;nucleus" "other molecular function" "Pf02297" "388753" "ENSG00000168275" "COA6" "hsa:388753; Q5JTJ2; Q5JTJ3; Q5JTJ4; Q8TA88" "Mitochondrial complex IV assembly" "Mitochondrial protein import" "2" "0" "0.930" "1.080" "0.971" "0.958" "0.811" "0.894" "0.947" "0.865" "0.398" "309.2" "287.6" "333.9" "300.2" "296.1" "250.8" "276.6" "292.7" "267.6" "123.2" "" "" "" "" "" "" "" "" "" "" "163.7" "159.5" "191.2" "138.3" "160.2" "139.5" "162.8" "159.8" "150.1" "123.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4119933875415276465" "False" "High" "IsMasterProtein" "P07902" "Galactose-1-phosphate uridylyltransferase OS=Homo sapiens OX=9606 GN=GALT PE=1 SV=3" "0.000" "False" "6.166" "5" "2" "5" "2" "379" "43.3" "6.99" "14.06" "2" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01087, Pf02744" "2592" "ENSG00000213930" "GALT" "B4E097; E7ET32; hsa:2592; P07902; Q14355; Q14356; Q14357; Q14358; Q14359; Q14360; Q14361; Q14363; Q14364; Q14365; Q14369; Q14370; Q14371; Q14372; Q14373; Q14374; Q14375; Q14377; Q14378; Q14380; Q14381; Q14382; Q14383; Q14384; Q14385; Q14386; Q14387; Q14389; Q16766; Q53XK1; Q5VZ81; Q96BY1" "Disorders of galactose metabolism ; Primary ovarian insufficiency" "Defective GALT can cause GALCT; Galactose catabolism" "4" "0" "1.022" "1.013" "1.006" "1.032" "0.987" "0.877" "0.872" "0.939" "0.531" "381.0" "389.4" "385.9" "383.4" "393.3" "376.2" "334.2" "332.2" "357.8" "202.3" "" "" "" "" "" "" "" "" "" "" "201.8" "215.9" "221.0" "176.6" "212.8" "209.3" "196.7" "181.3" "200.7" "202.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6631585726403495176" "False" "High" "IsMasterProtein" "O14787" "Transportin-2 OS=Homo sapiens OX=9606 GN=TNPO2 PE=1 SV=3" "0.000" "False" "6.163" "2" "2" "2" "1" "897" "101.3" "5.01" "6.53" "2" "transport" "nucleus;other cell component" "other molecular function" "Pf02985, Pf03810" "30000" "ENSG00000105576" "TNPO2" "hsa:30000; O14655; O14787; Q6IN77" "" "" "0" "0" "0.999" "1.069" "1.290" "0.821" "0.767" "1.147" "0.214" "0.919" "14.220" "19.3" "19.2" "20.6" "24.9" "15.8" "14.8" "22.1" "4.1" "17.7" "273.9" "" "" "" "" "" "" "" "" "" "" "10.2" "10.7" "11.8" "11.4" "8.6" "8.2" "13.0" "2.2" "9.9" "273.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7088025864314276117" "False" "High" "IsMasterProtein" "O95793" "Double-stranded RNA-binding protein Staufen homolog 1 OS=Homo sapiens OX=9606 GN=STAU1 PE=1 SV=2" "0.000" "False" "6.149" "4" "2" "2" "2" "577" "63.1" "9.44" "5.39" "2" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf16482" "6780" "ENSG00000124214" "STAU1" "A8K9Z4; E1P5Y1; E1P608; hsa:6780; O95793; Q5JW29; Q6GTM4; Q9H5B4; Q9H5B5; Q9Y3Q2" "" "" "0" "0" "1.011" "1.152" "1.134" "1.024" "0.979" "0.887" "1.064" "1.032" "0.900" "82.5" "83.4" "95.0" "93.5" "84.5" "80.7" "73.2" "87.8" "85.1" "74.2" "" "" "" "" "" "" "" "" "" "" "43.7" "46.2" "54.4" "43.1" "45.7" "44.9" "43.1" "47.9" "47.7" "74.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8026992804565503724" "False" "High" "IsMasterProtein" "Q13257" "Mitotic spindle assembly checkpoint protein MAD2A OS=Homo sapiens OX=9606 GN=MAD2L1 PE=1 SV=1" "0.000" "False" "6.144" "9" "2" "3" "2" "205" "23.5" "5.08" "9.55" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf02301" "4085" "ENSG00000164109" "MAD2L1" "hsa:4085; Q13257; Q53F56; Q548X9; Q6IRW7; Q8IZX3" "Regulation of sister chromatid separation at the metaphase-anaphase transition; Pleural mesothelioma" "RHO GTPases Activate Formins; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A" "13" "0" "0.992" "1.071" "1.096" "1.111" "1.112" "1.286" "1.119" "1.187" "2.269" "333.1" "330.5" "356.8" "365.1" "370.1" "370.5" "428.5" "372.9" "395.6" "755.8" "" "" "" "" "" "" "" "" "" "" "176.4" "183.3" "204.3" "168.1" "200.2" "206.1" "252.2" "203.5" "221.9" "755.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2618859431670300252" "False" "High" "IsMasterProtein" "Q5VSG8" "Glycoprotein endo-alpha-1,2-mannosidase-like protein OS=Homo sapiens OX=9606 GN=MANEAL PE=1 SV=1" "0.000" "False" "6.140" "2" "1" "1" "1" "457" "51.3" "6.98" "4.25" "1" "" "other membranes;ER/Golgi" "other molecular function" "Pf16317" "149175" "ENSG00000185090" "MANEAL" "hsa:149175; Q5VSG8; Q6DD86; Q6P497; Q8N5P8; Q96G55; Q96N42" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7547854547274614235" "False" "High" "IsMasterProtein" "Q66K74" "Microtubule-associated protein 1S OS=Homo sapiens OX=9606 GN=MAP1S PE=1 SV=2" "0.000" "False" "6.139" "1" "1" "1" "1" "1059" "112.1" "7.30" "3.31" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "" "55201" "ENSG00000130479" "MAP1S" "B4DH53; hsa:55201; Q27QB1; Q66K74; Q6NXF1; Q8N3L8; Q8N3W5; Q8NI88; Q96H94; Q96IT4; Q96SP8; Q9BRC6; Q9H928; Q9NVK7" "" "" "0" "0" "1.075" "0.953" "0.844" "1.025" "0.833" "0.996" "0.446" "0.987" "2.727" "25.7" "27.6" "24.5" "21.7" "26.3" "21.4" "25.6" "11.5" "25.4" "70.1" "" "" "" "" "" "" "" "" "" "" "13.6" "15.3" "14.0" "10.0" "14.2" "11.9" "15.1" "6.3" "14.2" "70.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4832676921386861974" "False" "High" "IsMasterProtein" "Q8WW33" "Gametocyte-specific factor 1 OS=Homo sapiens OX=9606 GN=GTSF1 PE=1 SV=2" "0.000" "False" "6.135" "13" "2" "2" "2" "167" "19.3" "6.51" "3.31" "2" "other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf05253" "121355" "ENSG00000170627" "GTSF1" "B3KQ60; hsa:121355; Q0VGM4; Q8N778; Q8WW33" "" "" "0" "0" "1.393" "0.982" "1.418" "1.655" "1.253" "1.332" "1.127" "1.371" "2.055" "32.9" "45.8" "32.3" "46.7" "54.5" "41.2" "43.8" "37.1" "45.1" "67.6" "" "" "" "" "" "" "" "" "" "" "17.4" "25.4" "18.5" "21.5" "29.5" "22.9" "25.8" "20.3" "25.3" "67.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6133678444779992417" "False" "High" "IsMasterProtein" "Q9UGU0" "Transcription factor 20 OS=Homo sapiens OX=9606 GN=TCF20 PE=1 SV=3" "0.000" "False" "6.132" "1" "2" "3" "2" "1960" "211.6" "9.04" "7.82" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13771" "6942" "ENSG00000100207; ENSG00000262024; ENSG00000276461" "TCF20" "A9JX12; hsa:6942; O14528; Q13078; Q4V353; Q9H4M0; Q9UGU0" "Matrix metalloproteinases" "" "1" "0" "1.305" "1.085" "1.576" "1.327" "1.509" "1.595" "1.789" "1.509" "1.010" "52.0" "67.8" "56.4" "81.9" "69.0" "78.4" "82.9" "93.0" "78.5" "52.5" "" "" "" "" "" "" "" "" "" "" "27.5" "37.6" "32.3" "37.7" "37.3" "43.6" "48.8" "50.8" "44.0" "52.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1355108408195266018" "False" "High" "IsMasterProtein" "Q6NZ67" "Mitotic-spindle organizing protein 2B OS=Homo sapiens OX=9606 GN=MZT2B PE=1 SV=1" "0.000" "False" "6.131" "14" "1" "1" "1" "158" "16.2" "10.15" "3.79" "1" "" "cytosol;cytoskeleton;nucleus" "" "Pf12926" "80097" "ENSG00000152082; ENSG00000292119" "MZT2B" "hsa:80097; Q6NZ67; Q96CG4" "" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7202922108567294127" "False" "High" "IsMasterProtein" "Q8IZP0" "Abl interactor 1 OS=Homo sapiens OX=9606 GN=ABI1 PE=1 SV=4" "0.000" "False" "6.127" "4" "2" "4" "1" "508" "55.0" "7.06" "10.75" "2" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00018, Pf07815" "10006" "ENSG00000136754" "ABI1" "A9Z1Y6; B3KX62; B4DQ58; H7BXI6; hsa:10006; O15147; O76049; O95060; Q5T2R3; Q5T2R4; Q5T2R6; Q5T2R7; Q5T2R9; Q5W070; Q5W072; Q8IZP0; Q8TB63; Q96S81; Q9NXZ9; Q9NYB8" "EGF/EGFR signaling pathway" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway" "8" "1" "1.060" "1.081" "0.912" "1.129" "1.073" "0.970" "1.041" "0.942" "1.513" "157.1" "166.6" "169.8" "143.3" "177.3" "168.6" "152.5" "163.6" "148.0" "237.7" "" "" "" "" "" "" "" "" "" "" "83.2" "92.4" "97.2" "66.0" "95.9" "93.8" "89.7" "89.3" "83.0" "237.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4531671785395663771" "False" "High" "IsMasterProtein" "Q5SXM8" "DNL-type zinc finger protein OS=Homo sapiens OX=9606 GN=DNLZ PE=1 SV=1" "0.000" "False" "6.121" "8" "1" "1" "1" "178" "19.2" "9.80" "3.93" "1" "protein metabolism;other metabolic processes;transport;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf05180" "728489" "ENSG00000213221" "DNLZ" "B2RUX5; B9EJE1; hsa:728489; Q5SXM8" "" "" "0" "0" "1.078" "1.143" "1.050" "0.981" "0.944" "0.916" "0.918" "0.723" "0.475" "53.2" "57.3" "60.8" "55.8" "52.2" "50.2" "48.7" "48.8" "38.4" "25.2" "" "" "" "" "" "" "" "" "" "" "28.2" "31.8" "34.8" "25.7" "28.2" "27.9" "28.7" "26.7" "21.6" "25.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5836561258245124912" "False" "High" "IsMasterProtein" "Q6P6C2" "RNA demethylase ALKBH5 OS=Homo sapiens OX=9606 GN=ALKBH5 PE=1 SV=2" "0.000" "False" "6.110" "5" "2" "2" "2" "394" "44.2" "9.09" "5.43" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf13532" "54890" "ENSG00000091542" "ALKBH5" "B4DVJ4; D3DXC6; hsa:54890; Q6P6C2; Q9NXD6" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Reversal of alkylation damage by DNA dioxygenases" "2" "0" "0.906" "1.037" "0.960" "1.280" "1.116" "1.187" "1.074" "1.092" "1.212" "180.2" "163.3" "186.9" "172.9" "230.7" "201.1" "213.8" "193.5" "196.8" "218.3" "" "" "" "" "" "" "" "" "" "" "95.4" "90.5" "107.1" "79.6" "124.8" "111.9" "125.8" "105.6" "110.4" "218.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7652692427915398655" "False" "High" "IsMasterProtein" "Q9H0H5" "Rac GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RACGAP1 PE=1 SV=1" "0.000" "False" "6.104" "3" "1" "1" "1" "632" "71.0" "8.88" "3.38" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00130, Pf00620" "29127" "ENSG00000161800" "RACGAP1" "hsa:29127; Q6PJ26; Q9H0H5; Q9NWN2; Q9P250; Q9P2W2" "S1P receptor signal transduction; Wnt signaling pathway and pluripotency" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; RHOC GTPase cycle; RHOA GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle" "13" "0" "1.058" "1.103" "1.528" "1.486" "1.149" "2.167" "2.070" "1.993" "1.963" "63.0" "66.7" "69.5" "96.3" "93.7" "72.4" "136.6" "130.5" "125.6" "123.7" "" "" "" "" "" "" "" "" "" "" "33.4" "37.0" "39.8" "44.4" "50.7" "40.3" "80.4" "71.2" "70.5" "123.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8200753479416328933" "False" "High" "IsMasterProtein" "Q8NF50" "Dedicator of cytokinesis protein 8 OS=Homo sapiens OX=9606 GN=DOCK8 PE=1 SV=3" "0.000" "False" "6.097" "1" "3" "3" "3" "2099" "238.4" "6.87" "4.89" "3" "cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity" "Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "81704" "ENSG00000107099" "DOCK8" "A2A350; A2BDF2; A4FU78; B7ZLP0; E9PH09; hsa:81704; Q3MV16; Q5JPJ1; Q8NF50; Q8TEP1; Q8WUY2; Q9BYJ5; Q9H1Q2; Q9H1Q3; Q9H308; Q9H7P2" "" "Factors involved in megakaryocyte development and platelet production; CDC42 GTPase cycle; RHOJ GTPase cycle; RAC1 GTPase cycle" "4" "0" "0.977" "1.017" "1.323" "1.033" "1.112" "1.174" "0.744" "0.992" "2.460" "158.9" "155.2" "161.7" "210.2" "164.2" "176.8" "186.7" "118.3" "157.6" "391.0" "" "" "" "" "" "" "" "" "" "" "84.2" "86.1" "92.6" "96.8" "88.8" "98.3" "109.9" "64.6" "88.4" "391.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2101401554741180333" "False" "High" "IsMasterProtein" "Q8N5M1" "ATP synthase mitochondrial F1 complex assembly factor 2 OS=Homo sapiens OX=9606 GN=ATPAF2 PE=1 SV=1" "0.000" "False" "6.091" "3" "1" "3" "1" "289" "32.8" "7.09" "5.46" "1" "cell organization and biogenesis" "cytosol;mitochondrion;nucleus" "" "Pf07542" "91647" "ENSG00000171953" "ATPAF2" "A6NDE5; A8K2J2; hsa:91647; Q6XYC7; Q8N5M1" "7q11.23 copy number variation syndrome; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "" "2" "0" "1.038" "0.985" "1.101" "1.001" "0.976" "1.092" "0.985" "0.982" "0.587" "288.8" "299.9" "284.5" "318.0" "289.2" "282.0" "315.4" "284.4" "283.7" "169.6" "" "" "" "" "" "" "" "" "" "" "152.9" "166.3" "163.0" "146.5" "156.5" "156.9" "185.6" "155.3" "159.1" "169.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6359108141380896600" "False" "High" "IsMasterProtein" "Q86W50" "RNA N6-adenosine-methyltransferase METTL16 OS=Homo sapiens OX=9606 GN=METTL16 PE=1 SV=2" "0.000" "False" "6.088" "4" "2" "2" "2" "562" "63.6" "7.85" "3.94" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05971" "79066" "ENSG00000127804" "METTL16" "D3DTI8; hsa:79066; Q86TE5; Q86W50; Q96T16; Q9BVG7" "" "" "0" "0" "1.243" "0.930" "1.483" "1.088" "0.894" "1.332" "1.053" "1.137" "1.362" "28.5" "35.4" "26.5" "42.3" "31.0" "25.5" "38.0" "30.0" "32.4" "38.8" "" "" "" "" "" "" "" "" "" "" "15.1" "19.6" "15.2" "19.5" "16.8" "14.2" "22.3" "16.4" "18.2" "38.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1597744866915900932" "False" "High" "IsMasterProtein" "P51114" "RNA-binding protein FXR1 OS=Homo sapiens OX=9606 GN=FXR1 PE=1 SV=3" "0.000" "False" "6.084" "3" "2" "2" "1" "621" "69.7" "6.15" "5.62" "2" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf05641, Pf12235, Pf16096, Pf16097, Pf17904, Pf18336" "8087" "ENSG00000114416" "FXR1" "A8K9B8; hsa:8087; P51114; Q7Z450; Q8N6R8" "Bile acids synthesis and enterohepatic circulation" "Signaling by BRAF and RAF1 fusions" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2576467063852337379" "False" "High" "IsMasterProtein" "Q12912" "Inositol 1,4,5-triphosphate receptor associated 2 OS=Homo sapiens OX=9606 GN=IRAG2 PE=1 SV=3" "0.000" "False" "6.084" "3" "2" "2" "2" "555" "62.1" "5.85" "5.47" "2" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf05781" "4033" "ENSG00000118308" "IRAG2" "A0AVM2; B4E077; hsa:4033; Q12912; Q8N301" "" "Neutrophil degranulation" "1" "0" "1.054" "1.022" "0.990" "1.315" "1.106" "1.187" "1.202" "1.191" "0.812" "115.8" "122.0" "118.4" "114.7" "152.3" "128.1" "137.4" "139.1" "137.9" "94.0" "" "" "" "" "" "" "" "" "" "" "61.3" "67.6" "67.8" "52.8" "82.4" "71.3" "80.9" "76.0" "77.3" "94.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9158242191706838173" "False" "High" "IsMasterProtein" "Q71RC2" "La-related protein 4 OS=Homo sapiens OX=9606 GN=LARP4 PE=1 SV=3" "0.000" "False" "6.078" "2" "1" "1" "1" "724" "80.5" "6.61" "3.59" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf05383" "113251" "ENSG00000161813" "LARP4" "A8K6T1; E9PDG5; G3XAA8; G5E976; hsa:113251; Q5CZ97; Q6ZV14; Q71RC2; Q96NF9" "" "" "0" "0" "0.914" "0.815" "1.058" "0.880" "0.831" "1.071" "0.966" "0.821" "0.874" "125.4" "114.6" "102.2" "132.7" "110.3" "104.3" "134.4" "121.2" "103.0" "109.6" "" "" "" "" "" "" "" "" "" "" "66.4" "63.5" "58.5" "61.1" "59.7" "58.0" "79.1" "66.1" "57.8" "109.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7912852613905627854" "False" "High" "IsMasterProtein" "Q01196" "Runt-related transcription factor 1 OS=Homo sapiens OX=9606 GN=RUNX1 PE=1 SV=3" "0.000" "False" "6.077" "5" "2" "3" "2" "453" "48.7" "9.35" "8.24" "2" "cell cycle OR cell proliferation;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00853, Pf08504" "861" "ENSG00000159216" "RUNX1" "A8MV94; B2RMS4; D3DSG1; hsa:861; O60472; O60473; O76047; O76089; Q01196; Q13081; Q13755; Q13756; Q13757; Q13758; Q13759; Q15341; Q15343; Q16122; Q16284; Q16285; Q16286; Q16346; Q16347; Q92479" "Hematopoietic stem cell differentiation; Dual hijack model of Vif in HIV infection; Orexin receptor pathway; Th17 cell differentiation pathway; Acute myeloid leukemia" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Estrogen-dependent gene expression; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RUNX1 regulates expression of components of tight junctions; Pre-NOTCH Transcription and Translation; RUNX1 regulates transcription of genes involved in differentiation of keratinocytes; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates estrogen receptor mediated transcription; RUNX1 regulates transcription of genes involved in WNT signaling; Organic cation transport; SARS-CoV-1 activates/modulates innate immune responses; Transcriptional regulation of granulopoiesis; RUNX3 regulates p14-ARF; RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs); RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; RUNX1 regulates transcription of genes involved in interleukin signaling; Regulation of RUNX1 Expression and Activity; RUNX2 regulates genes involved in differentiation of myeloid cells; RUNX1 regulates transcription of genes involved in BCR signaling" "24" "0" "0.919" "0.862" "1.211" "1.210" "1.033" "0.934" "0.924" "0.974" "1.237" "94.7" "87.0" "81.6" "114.6" "114.5" "97.8" "88.5" "87.5" "92.2" "117.1" "" "" "" "" "" "" "" "" "" "" "50.1" "48.3" "46.7" "52.8" "62.0" "54.4" "52.1" "47.8" "51.7" "117.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6002739480164065296" "False" "High" "IsMasterProtein" "Q14137" "Ribosome biogenesis protein BOP1 OS=Homo sapiens OX=9606 GN=BOP1 PE=1 SV=2" "0.000" "False" "6.074" "3" "2" "3" "2" "746" "83.6" "6.19" "7.55" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf08145" "23246" "ENSG00000261236" "BOP1" "hsa:23246; Q14137; Q969Z6; Q96IS8; Q96Q25; Q9BSA7; Q9BVM0" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.139" "1.338" "1.417" "1.362" "1.292" "1.217" "1.282" "1.277" "2.261" "76.1" "86.6" "101.8" "107.8" "103.6" "98.3" "92.6" "97.5" "97.1" "172.0" "" "" "" "" "" "" "" "" "" "" "40.3" "48.0" "58.3" "49.6" "56.0" "54.7" "54.5" "53.2" "54.5" "172.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7158651141849584646" "False" "High" "IsMasterProtein" "Q9Y294" "Histone chaperone ASF1A OS=Homo sapiens OX=9606 GN=ASF1A PE=1 SV=1" "0.000" "False" "6.066" "7" "1" "1" "1" "204" "23.0" "4.41" "3.48" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04729" "25842" "ENSG00000111875" "ASF1A" "hsa:25842; Q6IA08; Q9P014; Q9Y294" "22q11.2 copy number variation syndrome" "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "2" "0" "1.163" "1.238" "1.191" "1.224" "1.099" "1.061" "1.095" "1.331" "1.135" "47.6" "55.3" "58.9" "56.6" "58.2" "52.3" "50.5" "52.1" "63.3" "54.0" "" "" "" "" "" "" "" "" "" "" "25.2" "30.7" "33.7" "26.1" "31.5" "29.1" "29.7" "28.4" "35.5" "54.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7550232429458165552" "False" "High" "IsMasterProtein" "Q9NRZ9" "Lymphoid-specific helicase OS=Homo sapiens OX=9606 GN=HELLS PE=1 SV=1" "0.000" "False" "6.064" "2" "2" "3" "2" "838" "97.0" "7.93" "8.81" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00176, Pf00271" "3070" "ENSG00000119969" "HELLS" "B2RB41; hsa:3070; Q3LID1; Q6I7N7; Q76H76; Q76H77; Q76H78; Q76H79; Q76H80; Q76H81; Q7Z397; Q7Z5X2; Q8N6P4; Q9H4P5; Q9NRZ9" "Apoptosis; Apoptosis-related network due to altered Notch3 in ovarian cancer" "" "2" "0" "0.933" "0.988" "0.949" "1.031" "1.021" "1.687" "1.794" "1.692" "0.854" "271.3" "253.1" "268.0" "257.4" "279.8" "276.9" "457.8" "486.6" "459.1" "231.7" "" "" "" "" "" "" "" "" "" "" "143.7" "140.3" "153.5" "118.6" "151.4" "154.0" "269.4" "265.6" "257.6" "231.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1149947407616018825" "False" "High" "IsMasterProtein" "Q9NTX7" "E3 ubiquitin-protein ligase RNF146 OS=Homo sapiens OX=9606 GN=RNF146 PE=1 SV=1" "0.000" "False" "6.059" "4" "1" "1" "1" "359" "38.9" "5.33" "3.41" "1" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf02825, Pf13920" "81847" "ENSG00000118518" "RNF146" "E1P572; hsa:81847; Q6FIB2; Q7L8H4; Q96K03; Q96T06; Q9NTX6; Q9NTX7" "" "Degradation of AXIN; Ub-specific processing proteases; Regulation of PTEN stability and activity" "4" "0" "0.899" "0.712" "0.623" "0.836" "0.849" "1.011" "0.973" "0.970" "0.686" "35.7" "32.1" "25.4" "22.2" "29.8" "30.3" "36.1" "34.7" "34.6" "24.5" "" "" "" "" "" "" "" "" "" "" "18.9" "17.8" "14.6" "10.2" "16.1" "16.8" "21.2" "19.0" "19.4" "24.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1536948539302412641" "False" "High" "IsMasterProtein" "O60927" "E3 ubiquitin-protein ligase PPP1R11 OS=Homo sapiens OX=9606 GN=PPP1R11 PE=1 SV=1" "0.000" "False" "6.054" "13" "1" "1" "1" "126" "13.9" "7.01" "4.20" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf07491" "6992" "ENSG00000204619; ENSG00000206501; ENSG00000227720; ENSG00000233314; ENSG00000234058; ENSG00000236560; ENSG00000237403; ENSG00000237829" "PPP1R11" "hsa:6992; O60927" "" "" "0" "0" "1.072" "1.108" "1.180" "1.205" "1.070" "1.051" "1.006" "1.049" "0.831" "129.2" "138.5" "143.2" "152.5" "155.7" "138.3" "135.9" "130.0" "135.5" "107.4" "" "" "" "" "" "" "" "" "" "" "68.4" "76.8" "82.0" "70.2" "84.2" "76.9" "80.0" "71.0" "76.0" "107.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4596787228496680093" "False" "High" "IsMasterProtein" "Q9BV86" "N-terminal Xaa-Pro-Lys N-methyltransferase 1 OS=Homo sapiens OX=9606 GN=NTMT1 PE=1 SV=3" "0.000" "False" "6.053" "4" "2" "2" "2" "223" "25.4" "5.52" "6.53" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05891" "28989" "ENSG00000148335" "NTMT1" "A8K4J2; A8K8G7; hsa:28989; Q5SZB9; Q9BV86; Q9UI28" "" "" "0" "0" "0.886" "0.873" "1.160" "1.053" "0.883" "0.945" "0.727" "0.914" "1.242" "160.3" "142.1" "140.0" "186.0" "168.8" "141.5" "151.5" "116.5" "146.6" "199.2" "" "" "" "" "" "" "" "" "" "" "84.9" "78.8" "80.2" "85.7" "91.4" "78.7" "89.2" "63.6" "82.2" "199.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1141936988023863748" "False" "High" "IsMasterProtein" "Q9NP61" "ADP-ribosylation factor GTPase-activating protein 3 OS=Homo sapiens OX=9606 GN=ARFGAP3 PE=1 SV=1" "0.000" "False" "6.052" "4" "2" "2" "2" "516" "56.9" "7.36" "6.10" "2" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf01412" "26286" "ENSG00000242247" "ARFGAP3" "E9PB03; hsa:26286; Q9BSC6; Q9H9J0; Q9NP61; Q9NT10; Q9NUP5; Q9Y4V3; Q9Y4V4" "Ciliary landscape" "COPI-mediated anterograde transport; CDC42 GTPase cycle; RHOG GTPase cycle; COPI-dependent Golgi-to-ER retrograde traffic" "5" "0" "0.925" "1.263" "0.946" "1.032" "1.002" "1.059" "1.125" "1.104" "1.014" "93.5" "86.5" "118.1" "88.5" "96.5" "93.7" "99.1" "105.2" "103.3" "94.9" "" "" "" "" "" "" "" "" "" "" "49.5" "48.0" "67.7" "40.7" "52.2" "52.1" "58.3" "57.4" "57.9" "94.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3093573351125982310" "False" "High" "IsMasterProtein" "Q86WJ1" "Chromodomain-helicase-DNA-binding protein 1-like OS=Homo sapiens OX=9606 GN=CHD1L PE=1 SV=3" "0.000" "False" "6.046" "3" "3" "4" "3" "897" "100.9" "6.90" "6.77" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00176, Pf00271" "9557" "ENSG00000131778" "CHD1L" "A5YM64; B4DDE1; B5MDZ7; Q53EZ3; Q5VXX7; Q6DD94; Q6PK83; Q86WJ1; Q86XH3; Q96HF7; Q96SP3; Q9BVJ1; Q9NVV8" "1q21.1 copy number variation syndrome; Nucleotide excision repair in xeroderma pigmentosum" "Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "4" "0" "1.282" "1.126" "1.452" "1.104" "1.221" "1.312" "0.762" "1.095" "4.583" "64.8" "83.1" "73.0" "94.1" "71.5" "79.2" "85.0" "49.4" "71.0" "297.0" "" "" "" "" "" "" "" "" "" "" "34.3" "46.1" "41.8" "43.4" "38.7" "44.0" "50.0" "26.9" "39.8" "297.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7828842707520281021" "False" "High" "IsMasterProtein" "P41223" "Protein BUD31 homolog OS=Homo sapiens OX=9606 GN=BUD31 PE=1 SV=2" "0.000" "False" "6.045" "19" "2" "2" "2" "144" "17.0" "8.82" "5.57" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01125" "8896" "ENSG00000106245" "BUD31" "A4D274; B7Z4S9; D6W5S6; hsa:8896; P41223; Q6IB53; Q9UDV1" "" "mRNA Splicing - Major Pathway" "1" "0" "0.951" "1.091" "0.880" "1.006" "0.983" "1.032" "1.230" "1.017" "0.895" "285.2" "271.2" "311.1" "250.9" "286.9" "280.3" "294.4" "350.7" "290.1" "255.4" "" "" "" "" "" "" "" "" "" "" "151.0" "150.4" "178.2" "115.5" "155.2" "155.9" "173.3" "191.4" "162.7" "255.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "173468840260374204" "False" "High" "IsMasterProtein" "Q86WB0" "Zinc finger C3HC-type protein 1 OS=Homo sapiens OX=9606 GN=ZC3HC1 PE=1 SV=1" "0.000" "False" "6.026" "5" "2" "2" "2" "502" "55.2" "5.62" "4.71" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "other membranes;nucleus" "other molecular function" "Pf07967, Pf08600" "51530" "ENSG00000091732" "ZC3HC1" "A6NH66; hsa:51530; Q75MF3; Q75MF4; Q86WB0; Q8N330; Q96F75; Q9HA34; Q9NVX4; Q9P0R0" "" "Nuclear events stimulated by ALK signaling in cancer" "1" "0" "1.071" "0.936" "1.235" "1.159" "1.071" "1.520" "1.289" "1.275" "1.509" "104.4" "111.8" "97.7" "128.9" "121.0" "111.8" "158.6" "134.5" "133.0" "157.4" "" "" "" "" "" "" "" "" "" "" "55.3" "62.0" "55.9" "59.4" "65.5" "62.2" "93.3" "73.4" "74.6" "157.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4947084340596136770" "False" "High" "IsMasterProtein" "Q8TF05" "Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PPP4R1 PE=1 SV=1" "0.000" "False" "6.025" "2" "2" "3" "2" "950" "106.9" "4.77" "5.95" "2" "protein metabolism;other metabolic processes;signal transduction" "other cell component" "enzyme regulator activity" "Pf02985, Pf15017" "9989" "ENSG00000154845" "PPP4R1" "hsa:9989; Q8TF05; Q99774; Q9UNQ7" "16p11.2 proximal deletion syndrome" "" "1" "0" "0.976" "1.009" "0.936" "1.052" "0.967" "0.941" "0.954" "0.871" "1.293" "380.9" "371.6" "384.5" "356.7" "400.6" "368.4" "358.5" "363.2" "331.9" "492.5" "" "" "" "" "" "" "" "" "" "" "201.7" "206.0" "220.2" "164.3" "216.8" "204.9" "211.0" "198.3" "186.2" "492.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8347343991909543181" "False" "High" "IsMasterProtein" "P48200" "Iron-responsive element-binding protein 2 OS=Homo sapiens OX=9606 GN=IREB2 PE=1 SV=4" "0.000" "False" "6.021" "2" "2" "2" "2" "963" "105.0" "7.05" "5.92" "2" "other metabolic processes;transport;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00330, Pf00694" "3658" "ENSG00000136381" "IREB2" "A0A0A6YY96; A8KAC7; E1CJT9; H0YKU0; hsa:3658; P48200; Q13095; Q1HE21; Q59FQ7; Q8WVK6; Q9UF17" "Iron metabolism in placenta; Ferroptosis" "Iron uptake and transport" "3" "0" "0.946" "0.916" "1.012" "0.870" "0.879" "1.034" "0.873" "0.981" "1.826" "286.2" "270.8" "262.0" "289.5" "248.9" "251.6" "295.8" "249.8" "280.7" "522.5" "" "" "" "" "" "" "" "" "" "" "151.5" "150.1" "150.1" "133.3" "134.7" "139.9" "174.1" "136.4" "157.5" "522.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8834965082719872925" "False" "High" "IsMasterProtein" "Q96EQ0" "Small glutamine-rich tetratricopeptide repeat-containing protein beta OS=Homo sapiens OX=9606 GN=SGTB PE=1 SV=1" "0.000" "False" "6.019" "7" "2" "2" "2" "304" "33.4" "4.92" "4.98" "2" "cell organization and biogenesis;other biological processes" "other membranes;cytosol" "other molecular function" "Pf00515, Pf13414, Pf16546" "54557" "ENSG00000197860" "SGTB" "hsa:54557; Q96EQ0" "" "" "0" "0" "0.990" "0.995" "0.917" "1.054" "1.107" "1.044" "1.121" "1.147" "0.762" "123.6" "122.4" "123.0" "113.4" "130.3" "136.9" "129.1" "138.6" "141.8" "94.2" "" "" "" "" "" "" "" "" "" "" "65.5" "67.9" "70.4" "52.2" "70.5" "76.1" "76.0" "75.6" "79.5" "94.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6388610480367959150" "False" "High" "IsMasterProtein" "O15446" "DNA-directed RNA polymerase I subunit RPA34 OS=Homo sapiens OX=9606 GN=POLR1G PE=1 SV=1" "0.000" "False" "6.019" "3" "1" "1" "1" "510" "55.0" "8.51" "3.42" "1" "RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytosol;mitochondrion;nucleus;other cell component" "" "Pf08208" "10849" "ENSG00000117877" "POLR1G" "hsa:10849; O15446; Q32N11; Q7Z5U2; Q9UPF6" "2q13 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "6" "0" "1.605" "1.774" "1.719" "1.635" "1.310" "2.140" "1.610" "1.527" "1.167" "15.4" "24.7" "27.2" "26.4" "25.1" "20.1" "32.9" "24.7" "23.5" "17.9" "" "" "" "" "" "" "" "" "" "" "8.1" "13.7" "15.6" "12.2" "13.6" "11.2" "19.3" "13.5" "13.2" "17.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8390687985957490189" "False" "High" "IsMasterProtein" "Q5VTR2" "E3 ubiquitin-protein ligase BRE1A OS=Homo sapiens OX=9606 GN=RNF20 PE=1 SV=2" "0.000" "False" "6.013" "3" "3" "3" "3" "975" "113.6" "5.94" "4.24" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097" "56254" "ENSG00000155827" "RNF20" "A7MCT5; hsa:56254; Q2TB34; Q5VTR2; Q69YL5; Q6P527; Q8N3J4; Q96JD3; Q9H9Y7; Q9HA51; Q9NUR4; Q9NWQ3; Q9NX83" "ATM signaling in development and disease" "E3 ubiquitin ligases ubiquitinate target proteins; RHOBTB1 GTPase cycle" "3" "0" "0.931" "0.892" "1.000" "0.806" "0.939" "1.036" "0.797" "0.743" "0.649" "37.6" "35.0" "33.5" "37.5" "30.3" "35.3" "38.9" "29.9" "27.9" "24.4" "" "" "" "" "" "" "" "" "" "" "19.9" "19.4" "19.2" "17.3" "16.4" "19.6" "22.9" "16.3" "15.6" "24.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6342560622817440014" "False" "High" "IsMasterProtein" "Q96PU8" "KH domain-containing RNA-binding protein QKI OS=Homo sapiens OX=9606 GN=QKI PE=1 SV=1" "0.000" "False" "6.001" "5" "2" "3" "2" "341" "37.6" "8.56" "8.59" "2" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf16544, Pf16551" "9444" "ENSG00000112531" "QKI" "hsa:9444; Q2I375; Q5MJQ1; Q969L9; Q96EJ3; Q96KA3; Q96PU6; Q96PU7; Q96PU8; Q9P0X6; Q9P0X7; Q9P0X8; Q9P0X9; Q9P0Y0; Q9P0Y1" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation" "Signaling by BRAF and RAF1 fusions" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3972038562420252503" "False" "High" "IsMasterProtein" "P61254" "Large ribosomal subunit protein uL24 OS=Homo sapiens OX=9606 GN=RPL26 PE=1 SV=1" "0.000" "False" "5.993" "12" "2" "2" "2" "145" "17.2" "10.55" "6.50" "2" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00467, Pf16906" "6154" "ENSG00000161970" "RPL26" "B2R4F0; D3DTR8; hsa:6154; P61254; Q02877; Q6IPY2" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Peptide chain elongation; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "1.109" "1.011" "1.453" "1.375" "1.153" "1.086" "1.261" "1.243" "1.553" "131.8" "146.3" "133.3" "191.5" "181.3" "152.0" "143.2" "166.2" "163.8" "204.7" "" "" "" "" "" "" "" "" "" "" "69.8" "81.1" "76.3" "88.2" "98.1" "84.5" "84.3" "90.7" "91.9" "204.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4967759419043337591" "False" "High" "IsMasterProtein" "Q9UJ83" "2-hydroxyacyl-CoA lyase 1 OS=Homo sapiens OX=9606 GN=HACL1 PE=1 SV=2" "0.000" "False" "5.988" "3" "2" "2" "2" "578" "63.7" "7.36" "5.18" "2" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00205, Pf02775, Pf02776" "26061" "ENSG00000131373" "HACL1" "B4DWI1; B4DXI5; E9PEN4; hsa:26061; Q9BV42; Q9P0A2; Q9UJ83" "" "Peroxisomal protein import; Alpha-oxidation of phytanate" "2" "0" "0.920" "0.932" "0.882" "0.939" "0.911" "0.917" "0.737" "0.899" "0.545" "169.1" "155.5" "157.7" "149.1" "158.9" "154.0" "155.1" "124.6" "152.0" "92.1" "" "" "" "" "" "" "" "" "" "" "89.6" "86.2" "90.3" "68.7" "85.9" "85.7" "91.3" "68.0" "85.3" "92.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8230923864296422238" "False" "High" "IsMasterProtein" "Q9Y303" "N-acetylglucosamine-6-phosphate deacetylase OS=Homo sapiens OX=9606 GN=AMDHD2 PE=1 SV=2" "0.000" "False" "5.984" "5" "2" "3" "2" "409" "43.7" "6.70" "7.34" "2" "other metabolic processes" "cytosol" "other molecular function" "Pf01979" "51005" "ENSG00000162066" "AMDHD2" "B4DL77; hsa:51005; Q8WV54; Q9Y303" "" "Synthesis of UDP-N-acetyl-glucosamine" "1" "0" "1.103" "1.015" "1.072" "1.060" "0.909" "1.055" "1.034" "1.024" "0.702" "154.3" "170.2" "156.6" "165.4" "163.5" "140.2" "162.8" "159.6" "158.0" "108.3" "" "" "" "" "" "" "" "" "" "" "81.7" "94.4" "89.7" "76.2" "88.5" "78.0" "95.8" "87.1" "88.6" "108.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4137720252324409143" "False" "High" "IsMasterProtein" "O60716" "Catenin delta-1 OS=Homo sapiens OX=9606 GN=CTNND1 PE=1 SV=1" "0.000" "False" "5.978" "2" "2" "2" "2" "968" "108.1" "6.23" "4.76" "2" "cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00514" "1500" "ENSG00000198561" "CTNND1" "A8K939; hsa:1500; O15088; O60713; O60714; O60715; O60716; O60935; Q6DHZ7; Q6RBX8; Q9UP71; Q9UP72; Q9UP73" "VEGFA-VEGFR2 signaling; Wnt signaling pathway and pluripotency" "VEGFR2 mediated vascular permeability; Adherens junctions interactions; InlA-mediated entry of Listeria monocytogenes into host cells; Regulation of CDH11 function; Regulation of CDH19 Expression and Function; CDH11 homotypic and heterotypic interactions" "8" "0" "1.032" "0.992" "1.330" "1.125" "1.150" "1.914" "1.693" "2.001" "2.024" "108.8" "112.2" "108.0" "144.7" "122.4" "125.1" "208.2" "184.1" "217.7" "220.2" "" "" "" "" "" "" "" "" "" "" "57.6" "62.2" "61.8" "66.6" "66.2" "69.6" "122.5" "100.5" "122.1" "220.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7527678404860705700" "False" "High" "IsMasterProtein" "Q96K21" "Abscission/NoCut checkpoint regulator OS=Homo sapiens OX=9606 GN=ZFYVE19 PE=1 SV=3" "0.000" "False" "5.965" "6" "3" "3" "3" "471" "51.5" "5.73" "7.40" "3" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf01363" "84936" "ENSG00000166140" "ZFYVE19" "B3KVB2; C9JNF4; H3BUF9; hsa:84936; Q86WC2; Q8WU96; Q96K21" "" "" "0" "0" "0.866" "0.882" "1.029" "0.903" "0.892" "0.916" "0.957" "0.916" "0.577" "254.6" "220.5" "224.7" "262.1" "230.0" "227.1" "233.2" "243.8" "233.4" "146.8" "" "" "" "" "" "" "" "" "" "" "134.8" "122.2" "128.7" "120.7" "124.4" "126.3" "137.2" "133.1" "130.9" "146.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1007819713485126010" "False" "High" "IsMasterProtein" "P83916" "Chromobox protein homolog 1 OS=Homo sapiens OX=9606 GN=CBX1 PE=1 SV=1" "0.000" "False" "5.953" "15" "2" "2" "1" "185" "21.4" "4.93" "2.27" "2" "cell organization and biogenesis;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00385, Pf01393" "10951" "ENSG00000108468" "CBX1" "hsa:10951; P23197; P83916" "Effect of progerin on genes involved in progeria" "HCMV Early Events" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5094708502747754814" "False" "High" "IsMasterProtein" "P61313" "Large ribosomal subunit protein eL15 OS=Homo sapiens OX=9606 GN=RPL15 PE=1 SV=2" "0.000" "False" "5.949" "8" "2" "2" "2" "204" "24.1" "11.62" "5.34" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00827" "6138" "ENSG00000174748" "RPL15" "hsa:6138; P39030; P41051; P61313; Q5U0C0; Q642I1; Q6IPX6; Q8WYP2; Q96C44; Q9H2E5" "Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.062" "1.069" "1.336" "0.970" "1.181" "0.931" "0.883" "0.878" "0.678" "274.9" "291.9" "293.8" "367.2" "266.7" "324.6" "255.9" "242.8" "241.3" "186.4" "" "" "" "" "" "" "" "" "" "" "145.6" "161.8" "168.3" "169.1" "144.3" "180.6" "150.6" "132.5" "135.3" "186.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2699883784093853229" "False" "High" "IsMasterProtein" "Q8IY47" "Kelch repeat and BTB domain-containing protein 2 OS=Homo sapiens OX=9606 GN=KBTBD2 PE=1 SV=2" "0.000" "False" "5.945" "2" "1" "1" "1" "623" "71.3" "5.62" "3.84" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "" "" "Pf00651, Pf01344, Pf07707" "25948" "ENSG00000170852" "KBTBD2" "A8K9T7; hsa:25948; Q86Y62; Q8IY47; Q9P239; Q9UFM7; Q9Y382" "" "" "0" "0" "1.134" "0.966" "1.121" "1.115" "1.067" "1.185" "1.011" "0.936" "0.895" "176.6" "200.3" "170.6" "198.0" "196.9" "188.5" "209.3" "178.6" "165.2" "158.0" "" "" "" "" "" "" "" "" "" "" "93.5" "111.1" "97.7" "91.2" "106.5" "104.8" "123.2" "97.5" "92.7" "158.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4878144000314540155" "False" "High" "IsMasterProtein" "Q9NWU5" "Large ribosomal subunit protein uL22m OS=Homo sapiens OX=9606 GN=MRPL22 PE=1 SV=1" "0.000" "False" "5.940" "9" "2" "2" "2" "206" "23.6" "9.94" "5.27" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00237" "29093" "ENSG00000082515" "MRPL22" "A6NGJ8; hsa:29093; Q5H9Q1; Q96Q51; Q9NWU5; Q9P006" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.055" "0.995" "0.919" "0.989" "1.086" "0.907" "0.827" "0.978" "1.199" "376.7" "397.2" "374.7" "346.1" "372.4" "409.2" "341.7" "311.7" "368.6" "451.6" "" "" "" "" "" "" "" "" "" "" "199.5" "220.2" "214.6" "159.4" "201.5" "227.6" "201.1" "170.1" "206.8" "451.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4764020307768204184" "False" "High" "IsMasterProtein" "P61586" "Transforming protein RhoA OS=Homo sapiens OX=9606 GN=RHOA PE=1 SV=1" "0.000" "False" "5.937" "5" "1" "3" "1" "193" "21.8" "6.10" "7.61" "1" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "387" "ENSG00000067560" "RHOA" "hsa:387; P06749; P61586; Q53HM4; Q5U024; Q9UDJ0; Q9UEJ4" "Androgen receptor signaling pathway; Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Leptin signaling pathway; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; Focal adhesion; G protein signaling pathways; Wnt signaling pathway; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Wnt signaling pathway and pluripotency; Fibrin complement receptor 3 signaling pathway; Wnt signaling in kidney disease; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; Wnt signaling; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Leukocyte-intrinsic Hippo pathway functions; Neural crest cell migration during development; Neural crest cell migration in cancer; Joubert syndrome; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; GDNF signaling; PtdIns(4,5)P2 in cytokinesis pathway; 2q11.2 copy number variation syndrome; 2q21.1 copy number variation syndrome; G13 signaling pathway; 13q12.12 copy number variation; GNAQ pathways in port-wine stain; DNA damage response (only ATM dependent); Serotonin HTR1 group and FOS pathway" "Neutrophil degranulation; VEGFA-VEGFR2 Pathway; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHO GTPases Activate Formins; EPHB-mediated forward signaling; GPVI-mediated activation cascade; PI3K/AKT activation; ERBB2 Regulates Cell Motility; RHO GTPases activate CIT; G beta:gamma signalling through PI3Kgamma; PCP/CE pathway; RHO GTPases Activate Rhotekin and Rhophilins; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; Sema4D mediated inhibition of cell attachment and migration; Ovarian tumor domain proteases; SLIT2:ROBO1 increases RHOA activity; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); Axonal growth stimulation; Axonal growth inhibition (RHOA activation); RHO GTPases activate KTN1" "71" "0" "0.924" "0.856" "1.035" "1.007" "1.276" "1.008" "1.062" "0.969" "0.834" "51.8" "47.8" "44.3" "53.6" "52.1" "66.0" "52.2" "55.0" "50.2" "43.2" "" "" "" "" "" "" "" "" "" "" "27.4" "26.5" "25.4" "24.7" "28.2" "36.7" "30.7" "30.0" "28.2" "43.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6935074334363071802" "False" "High" "IsMasterProtein" "O00762" "Ubiquitin-conjugating enzyme E2 C OS=Homo sapiens OX=9606 GN=UBE2C PE=1 SV=1" "0.000" "False" "5.932" "6" "1" "1" "1" "179" "19.6" "7.37" "3.60" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "11065" "ENSG00000175063" "UBE2C" "A6NP33; E1P5N7; G3XAB7; hsa:11065; O00762" "Gastric cancer network 1; Gastric cancer network 2" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "21" "0" "1.144" "1.039" "0.900" "1.040" "1.072" "0.995" "0.744" "1.206" "3.712" "116.8" "133.6" "121.4" "105.1" "121.5" "125.3" "116.2" "86.8" "140.8" "433.5" "" "" "" "" "" "" "" "" "" "" "61.8" "74.1" "69.5" "48.4" "65.7" "69.7" "68.4" "47.4" "79.0" "433.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3951454542439150493" "False" "High" "IsMasterProtein" "Q9HB40" "Retinoid-inducible serine carboxypeptidase OS=Homo sapiens OX=9606 GN=SCPEP1 PE=1 SV=1" "0.000" "False" "5.927" "4" "2" "2" "2" "452" "50.8" "5.81" "5.56" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00450" "59342" "ENSG00000121064" "SCPEP1" "hsa:59342; Q96A94; Q9H3F0; Q9HB40" "" "" "0" "0" "1.218" "1.045" "1.269" "1.272" "1.153" "1.375" "1.218" "1.155" "0.821" "112.2" "136.6" "117.2" "142.3" "142.7" "129.3" "154.2" "136.7" "129.6" "92.1" "" "" "" "" "" "" "" "" "" "" "59.4" "75.7" "67.1" "65.5" "77.2" "71.9" "90.8" "74.6" "72.7" "92.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7794810011178551467" "False" "High" "IsMasterProtein" "O75348" "V-type proton ATPase subunit G 1 OS=Homo sapiens OX=9606 GN=ATP6V1G1 PE=1 SV=3" "0.000" "False" "5.921" "14" "2" "2" "2" "118" "13.7" "8.79" "5.23" "2" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf03179" "9550" "ENSG00000136888" "ATP6V1G1" "hsa:9550; O75348; Q6IB33" "Osteoclast signaling; Proximal tubule transport" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "7" "0" "1.039" "1.021" "1.005" "0.995" "1.025" "0.941" "0.980" "0.944" "0.669" "240.2" "249.7" "245.3" "241.4" "239.0" "246.1" "226.0" "235.3" "226.8" "160.8" "" "" "" "" "" "" "" "" "" "" "127.2" "138.4" "140.5" "111.2" "129.3" "136.9" "133.0" "128.5" "127.3" "160.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1344142120960836563" "False" "High" "IsMasterProtein" "Q9BWS9" "Chitinase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CHID1 PE=1 SV=1" "0.000" "False" "5.916" "6" "3" "3" "3" "393" "44.9" "8.63" "5.41" "3" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00704" "66005" "ENSG00000177830" "CHID1" "B3KWB0; hsa:66005; Q8NBM9; Q96CZ3; Q96S93; Q96SK0; Q9BWS9; Q9BY52" "" "Platelet degranulation" "1" "0" "0.960" "0.990" "1.073" "1.031" "1.052" "1.118" "0.941" "1.087" "2.092" "229.5" "220.2" "227.2" "246.3" "236.5" "241.5" "256.4" "215.9" "249.3" "480.0" "" "" "" "" "" "" "" "" "" "" "121.5" "122.1" "130.1" "113.4" "128.0" "134.3" "150.9" "117.8" "139.9" "480.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8312057505130700222" "False" "High" "IsMasterProtein" "P06865" "Beta-hexosaminidase subunit alpha OS=Homo sapiens OX=9606 GN=HEXA PE=1 SV=2" "0.000" "False" "5.915" "3" "2" "3" "1" "529" "60.7" "5.16" "8.40" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00728, Pf14845" "3073" "ENSG00000213614" "HEXA" "B4DKE7; E7ENH7; hsa:3073; P06865; Q53HS8; Q6AI32" "Degradation pathway of sphingolipids, including diseases; Glycosaminoglycan degradation" "CS/DS degradation; Hyaluronan uptake and degradation; Glycosphingolipid catabolism; Keratan sulfate degradation; Defective HEXA causes GM2G1" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5925761923209875400" "False" "High" "IsMasterProtein" "Q12824" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 OS=Homo sapiens OX=9606 GN=SMARCB1 PE=1 SV=2" "0.000" "False" "5.910" "3" "1" "1" "1" "385" "44.1" "6.23" "3.71" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04855, Pf21459" "6598" "ENSG00000099956; ENSG00000275837" "SMARCB1" "hsa:6598; O75784; O95474; Q12824; Q17S11; Q38GA1; Q76N08; Q9UBH2" "Tumor suppressor activity of SMARCB1; Thermogenesis; Modulators of TCR signaling and T cell activation; DYRK1A involvement regarding cell proliferation in brain development; Kleefstra syndrome; 10q11.21q11.23 copy number variation syndrome" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7173592296681882204" "False" "High" "IsMasterProtein" "Q15651" "High mobility group nucleosome-binding domain-containing protein 3 OS=Homo sapiens OX=9606 GN=HMGN3 PE=1 SV=2" "0.000" "False" "5.910" "17" "2" "5" "2" "99" "10.7" "9.66" "8.94" "2" "cell organization and biogenesis" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "9324" "ENSG00000118418" "HMGN3" "B2RD37; hsa:9324; Q15651; Q5HYD3; Q7RTT0; Q969M5; Q9BZT7" "" "" "0" "0" "0.950" "0.956" "0.959" "0.763" "0.744" "0.849" "0.910" "0.831" "0.404" "890.9" "846.3" "851.8" "854.5" "679.9" "663.2" "756.8" "810.8" "740.4" "360.0" "" "" "" "" "" "" "" "" "" "" "471.7" "469.2" "487.8" "393.5" "367.8" "368.9" "445.4" "442.6" "415.4" "360.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5817906340983341960" "False" "High" "IsMasterProtein" "P61956" "Small ubiquitin-related modifier 2 OS=Homo sapiens OX=9606 GN=SUMO2 PE=1 SV=3" "0.000" "False" "5.909" "23" "2" "5" "1" "95" "10.9" "5.50" "15.40" "2" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf11976" "6613" "ENSG00000188612" "SUMO2" "B2R4I2; hsa:6613; P55855; P61956; Q32Q42; Q6IPZ6; Q96HK1" "TAR syndrome" "SUMOylation of DNA damage response and repair proteins; Processing of DNA double-strand break ends; SUMOylation of chromatin organization proteins; SUMOylation of intracellular receptors; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed" "15" "0" "0.828" "0.919" "0.750" "0.953" "0.833" "0.936" "0.775" "1.047" "0.575" "559.2" "462.8" "514.0" "419.3" "533.1" "466.0" "523.2" "433.2" "585.5" "321.4" "" "" "" "" "" "" "" "" "" "" "296.1" "256.6" "294.3" "193.1" "288.4" "259.2" "307.9" "236.5" "328.5" "321.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "965973480370309944" "False" "High" "IsMasterProtein" "Q53HC9" "EARP and GARP complex-interacting protein 1 OS=Homo sapiens OX=9606 GN=EIPR1 PE=1 SV=2" "0.000" "False" "5.905" "5" "2" "3" "2" "387" "43.6" "5.06" "9.43" "2" "protein metabolism;other metabolic processes;transport;other biological processes" "ER/Golgi" "" "Pf00400" "7260" "ENSG00000032389" "EIPR1" "D6W4Y1; hsa:7260; O43179; Q53HC9; Q53S19; Q53SG2" "Ciliary landscape" "" "1" "0" "1.050" "1.105" "1.020" "1.010" "1.059" "1.076" "1.017" "1.023" "0.808" "310.3" "325.8" "342.9" "316.5" "313.5" "328.6" "333.9" "315.4" "317.2" "250.7" "" "" "" "" "" "" "" "" "" "" "164.3" "180.7" "196.4" "145.7" "169.6" "182.8" "196.5" "172.2" "178.0" "250.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8862135404577219062" "False" "High" "IsMasterProtein" "Q9UJZ1" "Stomatin-like protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=STOML2 PE=1 SV=1" "0.000" "False" "5.905" "3" "1" "1" "1" "356" "38.5" "7.39" "3.48" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;mitochondrion" "signal transduction activity or receptor binding;other molecular function" "Pf01145, Pf16200" "30968" "ENSG00000165283" "STOML2" "B4E1K7; D3DRN3; hsa:30968; O60376; Q53G29; Q96FY2; Q9P042; Q9UJZ1" "" "Processing of SMDT1; Cellular response to mitochondrial stress" "2" "0" "0.982" "1.057" "1.131" "1.048" "1.105" "1.177" "1.042" "1.167" "0.781" "113.4" "111.4" "119.8" "128.2" "118.8" "125.3" "133.4" "118.1" "132.3" "88.5" "" "" "" "" "" "" "" "" "" "" "60.0" "61.7" "68.6" "59.1" "64.3" "69.7" "78.5" "64.5" "74.2" "88.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "57787487465406304" "False" "High" "IsMasterProtein" "Q08945" "FACT complex subunit SSRP1 OS=Homo sapiens OX=9606 GN=SSRP1 PE=1 SV=1" "0.000" "False" "5.893" "2" "1" "1" "1" "709" "81.0" "6.87" "3.98" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00505, Pf03531, Pf08512, Pf17292, Pf21092, Pf21103" "6749" "ENSG00000149136" "SSRP1" "hsa:6749; Q08945; Q5BJG8" "" "Regulation of TP53 Activity through Phosphorylation; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "12" "0" "0.883" "0.915" "1.004" "1.033" "0.810" "1.533" "1.796" "1.562" "0.587" "90.5" "79.9" "82.8" "90.8" "93.5" "73.3" "138.7" "162.5" "141.3" "53.1" "" "" "" "" "" "" "" "" "" "" "47.9" "44.3" "47.4" "41.8" "50.6" "40.7" "81.7" "88.7" "79.3" "53.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8417235359346522376" "False" "High" "IsMasterProtein" "Q9NR12" "PDZ and LIM domain protein 7 OS=Homo sapiens OX=9606 GN=PDLIM7 PE=1 SV=1" "0.000" "False" "5.893" "4" "2" "2" "2" "457" "49.8" "8.41" "6.59" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595" "9260" "ENSG00000196923" "PDLIM7" "hsa:9260; Q14250; Q5XG82; Q6NVZ5; Q96C91; Q9BXB8; Q9BXB9; Q9NR12" "Ebstein-Barr virus LMP1 signaling; GDNF signaling; 5q35 copy number variation" "RET signaling" "4" "0" "0.995" "1.088" "1.028" "1.081" "0.977" "1.002" "0.927" "1.007" "1.837" "295.8" "294.3" "321.8" "303.9" "319.9" "289.0" "296.4" "274.1" "297.9" "543.4" "" "" "" "" "" "" "" "" "" "" "156.6" "163.1" "184.3" "140.0" "173.1" "160.8" "174.4" "149.6" "167.1" "543.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7384087443166083849" "False" "High" "IsMasterProtein" "O14562" "Ubiquitin domain-containing protein UBFD1 OS=Homo sapiens OX=9606 GN=UBFD1 PE=1 SV=2" "0.000" "False" "5.882" "6" "1" "1" "1" "309" "33.4" "5.77" "2.24" "1" "" "" "" "Pf00240" "56061" "ENSG00000103353" "UBFD1" "A8MW58; D3DWF2; hsa:56061; O14562" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7152432727454643144" "False" "High" "IsMasterProtein" "Q6PII3" "Coiled-coil domain-containing protein 174 OS=Homo sapiens OX=9606 GN=CCDC174 PE=1 SV=3" "0.000" "False" "5.878" "4" "2" "3" "2" "467" "53.9" "6.33" "7.72" "2" "" "nucleus" "" "Pf13300" "51244" "ENSG00000154781" "CCDC174" "hsa:51244; Q6PII3; Q96CS5" "" "" "0" "0" "1.052" "0.726" "0.879" "1.016" "0.966" "0.734" "0.653" "0.803" "0.616" "35.9" "37.8" "26.1" "31.6" "36.5" "34.7" "26.4" "23.5" "28.9" "22.1" "" "" "" "" "" "" "" "" "" "" "19.0" "21.0" "14.9" "14.5" "19.7" "19.3" "15.5" "12.8" "16.2" "22.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1583521273813264514" "False" "High" "IsMasterProtein" "P35236" "Tyrosine-protein phosphatase non-receptor type 7 OS=Homo sapiens OX=9606 GN=PTPN7 PE=1 SV=3" "0.000" "False" "5.876" "6" "2" "2" "2" "360" "40.5" "6.79" "2.68" "2" "protein metabolism;other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00102" "5778" "ENSG00000143851" "PTPN7" "B3KXE1; hsa:5778; P35236; Q53XK4; Q5SXQ0; Q5SXQ1; Q9BV05" "MAPK signaling pathway; IL-18 signaling pathway" "Interleukin-37 signaling; Negative regulation of MAPK pathway" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-788718536083084523" "False" "High" "IsMasterProtein" "Q9ULR0" "Pre-mRNA-splicing factor ISY1 homolog OS=Homo sapiens OX=9606 GN=ISY1 PE=1 SV=3" "0.000" "False" "5.876" "6" "2" "2" "2" "285" "33.0" "5.17" "6.11" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf06246" "100534599; 57461" "ENSG00000240682" "ISY1" "hsa:100534599; hsa:57461; Q96IL2; Q9BT05; Q9ULR0" "" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "5" "0" "1.001" "0.865" "0.890" "0.934" "0.965" "1.033" "1.130" "1.135" "0.821" "336.5" "336.8" "291.0" "299.6" "314.4" "324.6" "347.8" "380.1" "382.0" "276.2" "" "" "" "" "" "" "" "" "" "" "178.2" "186.7" "166.6" "138.0" "170.1" "180.6" "204.7" "207.5" "214.3" "276.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4842107794335973179" "False" "High" "IsMasterProtein" "P15336" "Cyclic AMP-dependent transcription factor ATF-2 OS=Homo sapiens OX=9606 GN=ATF2 PE=1 SV=4" "0.000" "False" "5.872" "4" "3" "3" "1" "505" "54.5" "7.88" "4.73" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "1386" "ENSG00000115966" "ATF2" "A1L3Z2; A4D7U4; A4D7U5; A4D7V1; D3DPE9; G8JLM5; hsa:1386; P15336; Q13000; Q3B7B7; Q4ZFU9; Q53RY2; Q8TAR1; Q96JT8" "Energy metabolism; IL-1 signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; ATM signaling pathway; Interleukin-1 (IL-1) structural pathway; Myometrial relaxation and contraction pathways; Photodynamic therapy-induced AP-1 survival signaling; TGF-beta signaling pathway; MAPK signaling pathway; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; DNA IR-double strand breaks and cellular response via ATM; Ethanol effects on histone modifications; p38 MAPK signaling pathway; PI3K-Akt signaling pathway; Thermogenesis; Gastrin signaling pathway; Hepatitis B infection; Thyroid hormones production and peripheral downstream signaling effects; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; 10q11.21q11.23 copy number variation syndrome; T-cell receptor signaling pathway" "NGF-stimulated transcription; Heme signaling; Regulation of PTEN gene transcription; TP53 Regulates Transcription of DNA Repair Genes; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; Estrogen-dependent gene expression; HATs acetylate histones; Activation of the AP-1 family of transcription factors; Response of EIF2AK4 (GCN2) to amino acid deficiency" "36" "0" "1.169" "0.913" "0.856" "1.088" "0.957" "1.087" "1.074" "1.078" "0.797" "56.0" "65.5" "51.1" "48.0" "60.9" "53.6" "60.9" "60.1" "60.3" "44.6" "" "" "" "" "" "" "" "" "" "" "29.6" "36.3" "29.3" "22.1" "33.0" "29.8" "35.8" "32.8" "33.8" "44.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2435225049251902172" "False" "High" "IsMasterProtein" "Q8NEY8" "Periphilin-1 OS=Homo sapiens OX=9606 GN=PPHLN1 PE=1 SV=2" "0.000" "False" "5.871" "3" "2" "2" "2" "458" "52.7" "9.11" "6.10" "2" "cell organization and biogenesis;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf11488" "51535" "ENSG00000134283" "PPHLN1" "E9PAX8; hsa:51535; Q86YT2; Q8IXN3; Q8NEY8; Q8TB09; Q96NB9; Q9NXL4; Q9P0P6; Q9P0R9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8899762439150821704" "False" "High" "IsMasterProtein" "Q9H9Q4" "Non-homologous end-joining factor 1 OS=Homo sapiens OX=9606 GN=NHEJ1 PE=1 SV=1" "0.000" "False" "5.869" "5" "1" "1" "1" "299" "33.3" "5.97" "3.58" "1" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09302" "79840" "ENSG00000187736" "NHEJ1" "B8ZZA4; hsa:79840; Q4ZFW7; Q6IA64; Q96JS9; Q9H9Q4" "Non-homologous end joining; DNA repair pathways, full network" "Nonhomologous End-Joining (NHEJ)" "3" "0" "0.912" "1.057" "1.009" "1.103" "0.925" "0.887" "1.182" "1.076" "0.611" "163.8" "149.3" "173.0" "165.2" "180.6" "151.5" "145.2" "193.6" "176.2" "100.0" "" "" "" "" "" "" "" "" "" "" "86.7" "82.8" "99.1" "76.1" "97.7" "84.3" "85.5" "105.7" "98.8" "100.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-143757823348630571" "False" "High" "IsMasterProtein" "Q8IV08" "5'-3' exonuclease PLD3 OS=Homo sapiens OX=9606 GN=PLD3 PE=1 SV=1" "0.000" "False" "5.861" "4" "2" "2" "2" "490" "54.7" "6.47" "5.36" "2" "DNA metabolism;stress response;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf13918" "23646" "ENSG00000105223" "PLD3" "hsa:23646; Q8IV08; Q92853; Q9BW87" "" "Role of phospholipids in phagocytosis; Synthesis of PG" "2" "0" "1.071" "0.952" "1.071" "1.068" "1.098" "1.113" "0.832" "0.931" "1.109" "56.5" "60.5" "53.8" "60.5" "60.3" "62.0" "62.9" "47.0" "52.6" "62.6" "" "" "" "" "" "" "" "" "" "" "29.9" "33.5" "30.8" "27.8" "32.6" "34.5" "37.0" "25.6" "29.5" "62.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7454062146017555339" "False" "High" "IsMasterProtein" "P32019" "Type II inositol 1,4,5-trisphosphate 5-phosphatase OS=Homo sapiens OX=9606 GN=INPP5B PE=1 SV=4" "0.000" "False" "5.840" "2" "3" "3" "3" "993" "112.8" "5.57" "4.81" "3" "other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00620, Pf16776, Pf21310" "3633" "ENSG00000204084" "INPP5B" "C9J6U5; hsa:3633; P32019; Q5VSG9; Q5VSH0; Q5VSH1; Q658Q5; Q6P6D4; Q6PD53; Q86YE1" "" "Synthesis of IP2, IP, and Ins in the cytosol; Synthesis of IP3 and IP4 in the cytosol" "2" "0" "1.165" "1.003" "0.941" "0.768" "0.898" "1.010" "0.901" "0.894" "2.639" "57.4" "66.9" "57.6" "54.0" "44.1" "51.5" "58.0" "51.7" "51.3" "151.4" "" "" "" "" "" "" "" "" "" "" "30.4" "37.1" "33.0" "24.9" "23.9" "28.7" "34.1" "28.2" "28.8" "151.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1233062915994962718" "False" "High" "IsMasterProtein" "Q9HC16" "DNA dC->dU-editing enzyme APOBEC-3G OS=Homo sapiens OX=9606 GN=APOBEC3G PE=1 SV=1" "0.000" "False" "5.835" "4" "2" "2" "2" "384" "46.4" "8.00" "5.69" "2" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05240, Pf18782" "60489" "ENSG00000239713" "APOBEC3G" "B2RDR9; hsa:60489; Q45F02; Q5TF77; Q7Z2N1; Q7Z2N4; Q9H9H8; Q9HC16" "Dual hijack model of Vif in HIV infection" "" "1" "0" "1.039" "0.939" "0.944" "1.045" "1.081" "0.968" "0.910" "0.880" "0.798" "277.6" "288.5" "260.6" "262.0" "290.1" "300.1" "268.6" "252.7" "244.2" "221.6" "" "" "" "" "" "" "" "" "" "" "147.0" "159.9" "149.3" "120.7" "156.9" "166.9" "158.1" "138.0" "137.0" "221.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1058361017873513588" "False" "High" "IsMasterProtein" "P63173" "Large ribosomal subunit protein eL38 OS=Homo sapiens OX=9606 GN=RPL38 PE=1 SV=2" "0.000" "False" "5.825" "24" "2" "5" "2" "70" "8.2" "10.10" "12.48" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01781" "6169" "ENSG00000172809" "RPL38" "B2R5A8; hsa:6169; P23411; P63173" "Mesodermal commitment pathway; Mesodermal commitment pathway; Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Response of EIF2AK4 (GCN2) to amino acid deficiency; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "16" "0" "1.118" "1.136" "1.368" "1.296" "1.426" "1.435" "1.505" "1.517" "1.195" "390.7" "437.0" "443.9" "534.4" "506.5" "557.4" "560.5" "588.1" "592.9" "467.0" "" "" "" "" "" "" "" "" "" "" "206.9" "242.3" "254.2" "246.1" "274.0" "310.0" "329.9" "321.0" "332.6" "467.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5154209306994627467" "False" "High" "IsMasterProtein" "Q14938" "Nuclear factor 1 X-type OS=Homo sapiens OX=9606 GN=NFIX PE=1 SV=2" "0.000" "False" "5.823" "4" "2" "3" "1" "502" "55.1" "8.68" "4.71" "2" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00859, Pf03165, Pf10524" "4784" "ENSG00000008441" "NFIX" "B4DM25; hsa:4784; O60413; Q0VG09; Q12859; Q13050; Q13052; Q14938; Q5U094; Q9UPH1; Q9Y6R8" "Oxidative stress response" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5102394332226681343" "False" "High" "IsMasterProtein" "Q05932" "Folylpolyglutamate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=FPGS PE=1 SV=3" "0.000" "False" "5.819" "3" "2" "2" "2" "587" "64.6" "7.94" "4.85" "2" "cell cycle OR cell proliferation;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "" "2356" "ENSG00000136877" "FPGS" "B3KPW4; B7Z2Z3; F5H0K6; hsa:2356; Q05932; Q5JU19; Q5JU22; Q6P2P6" "Fluoropyrimidine activity" "" "1" "0" "1.128" "1.272" "1.434" "1.168" "1.085" "1.271" "0.781" "1.271" "5.221" "67.4" "76.1" "85.8" "96.7" "78.8" "73.1" "85.7" "52.7" "85.7" "352.1" "" "" "" "" "" "" "" "" "" "" "35.7" "42.2" "49.1" "44.5" "42.6" "40.7" "50.4" "28.8" "48.1" "352.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5021225223718005983" "False" "High" "IsMasterProtein" "P31949" "Protein S100-A11 OS=Homo sapiens OX=9606 GN=S100A11 PE=1 SV=2" "0.000" "False" "5.806" "24" "3" "4" "3" "105" "11.7" "7.12" "11.61" "3" "signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00036, Pf01023" "6282" "ENSG00000163191" "S100A11" "hsa:6282; P31949; Q5VTK0" "" "Neutrophil degranulation" "1" "0" "1.010" "1.011" "0.945" "1.023" "0.930" "0.971" "1.033" "0.997" "0.472" "660.4" "667.3" "667.4" "624.1" "675.4" "614.4" "641.3" "682.0" "658.3" "311.6" "" "" "" "" "" "" "" "" "" "" "349.7" "370.0" "382.2" "287.4" "365.4" "341.8" "377.4" "372.3" "369.3" "311.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "680199301258843894" "False" "High" "IsMasterProtein" "O95229" "ZW10 interactor OS=Homo sapiens OX=9606 GN=ZWINT PE=1 SV=2" "0.000" "False" "5.803" "8" "2" "2" "2" "277" "31.3" "5.15" "2.69" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf15556" "11130" "ENSG00000122952" "ZWINT" "A6NNV6; hsa:11130; O95229; Q0D2I3; Q9BWD0" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "1.100" "0.981" "1.107" "0.964" "1.032" "1.081" "0.845" "0.987" "1.872" "107.8" "118.6" "105.7" "119.3" "103.9" "111.2" "116.5" "91.1" "106.4" "201.8" "" "" "" "" "" "" "" "" "" "" "57.1" "65.7" "60.5" "54.9" "56.2" "61.8" "68.6" "49.7" "59.7" "201.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-428002072210945893" "False" "High" "IsMasterProtein" "P52657" "Transcription initiation factor IIA subunit 2 OS=Homo sapiens OX=9606 GN=GTF2A2 PE=1 SV=1" "0.000" "False" "5.800" "20" "3" "4" "3" "109" "12.4" "6.62" "10.28" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02268, Pf02751" "2958" "ENSG00000140307" "GTF2A2" "A8MYQ7; hsa:2958; P52657; Q6FGB5" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Estrogen-dependent gene expression" "11" "0" "0.976" "1.043" "0.906" "0.961" "1.007" "0.968" "0.994" "0.971" "0.544" "414.2" "404.2" "432.2" "375.1" "398.1" "417.0" "401.0" "411.5" "402.2" "225.3" "" "" "" "" "" "" "" "" "" "" "219.3" "224.1" "247.5" "172.8" "215.4" "232.0" "236.0" "224.6" "225.6" "225.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-763212604296308746" "False" "High" "IsMasterProtein" "Q8IXH7" "Negative elongation factor C/D OS=Homo sapiens OX=9606 GN=NELFCD PE=1 SV=2" "0.000" "False" "5.799" "3" "2" "2" "2" "590" "66.2" "5.10" "5.49" "2" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf04858" "51497" "ENSG00000101158" "NELFCD" "B4DE06; hsa:51497; Q8IXH7; Q9BYL2; Q9H405; Q9H888; Q9H8T3; Q9NVX5; Q9P029; Q9UGN1; Q9UGN2; Q9UGN3" "Initiation of transcription and translation elongation at the HIV-1 LTR; 4p16.3 copy number variation" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "16" "0" "1.293" "1.200" "1.335" "1.376" "1.043" "1.428" "0.644" "0.823" "8.452" "38.5" "49.8" "46.2" "51.5" "53.0" "40.2" "55.0" "24.8" "31.7" "325.7" "" "" "" "" "" "" "" "" "" "" "20.4" "27.6" "26.5" "23.7" "28.7" "22.3" "32.4" "13.5" "17.8" "325.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3372054881013806202" "False" "High" "IsMasterProtein" "Q9NVZ3" "Adaptin ear-binding coat-associated protein 2 OS=Homo sapiens OX=9606 GN=NECAP2 PE=1 SV=1" "0.000" "False" "5.797" "7" "2" "3" "2" "263" "28.3" "8.38" "8.03" "2" "transport" "other membranes" "" "Pf07933" "55707" "ENSG00000157191; ENSG00000291380" "NECAP2" "B4DY19; E9PGQ8; hsa:55707; Q5VSU4; Q5VSU5; Q9H7L1; Q9H8L1; Q9NVZ3" "" "Cargo recognition for clathrin-mediated endocytosis" "2" "0" "1.127" "1.002" "0.992" "1.186" "0.972" "1.026" "0.994" "1.188" "0.885" "270.1" "304.4" "270.6" "267.8" "320.4" "262.5" "277.1" "268.4" "320.9" "239.1" "" "" "" "" "" "" "" "" "" "" "143.0" "168.8" "155.0" "123.3" "173.3" "146.0" "163.1" "146.5" "180.0" "239.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-145222249138625553" "False" "High" "IsMasterProtein" "Q9BYG3" "MKI67 FHA domain-interacting nucleolar phosphoprotein OS=Homo sapiens OX=9606 GN=NIFK PE=1 SV=1" "0.000" "False" "5.795" "3" "1" "2" "1" "293" "34.2" "9.88" "4.18" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf12196" "84365" "ENSG00000155438" "NIFK" "A8K788; hsa:84365; Q8TB66; Q96ED4; Q9BYG3" "" "" "0" "0" "1.079" "1.001" "1.104" "1.044" "1.013" "1.102" "1.126" "1.129" "1.541" "73.2" "78.9" "73.2" "80.8" "76.4" "74.1" "80.6" "82.4" "82.6" "112.8" "" "" "" "" "" "" "" "" "" "" "38.7" "43.8" "41.9" "37.2" "41.3" "41.2" "47.5" "45.0" "46.3" "112.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4372358057775812967" "False" "High" "IsMasterProtein" "Q9UMZ2" "Synergin gamma OS=Homo sapiens OX=9606 GN=SYNRG PE=1 SV=2" "0.000" "False" "5.792" "2" "2" "2" "2" "1314" "140.6" "5.03" "4.88" "2" "transport" "other membranes;ER/Golgi;other cell component" "" "" "11276" "ENSG00000274047; ENSG00000275066" "SYNRG" "A8MWU4; B7ZKZ2; B7ZKZ3; hsa:11276; Q17RI2; Q5BKU5; Q6ZT17; Q9UMZ2" "17q12 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1650974207865814862" "False" "High" "IsMasterProtein" "P04818" "Thymidylate synthase OS=Homo sapiens OX=9606 GN=TYMS PE=1 SV=3" "0.000" "False" "5.792" "5" "2" "3" "2" "313" "35.7" "7.01" "9.21" "2" "DNA metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00303" "7298" "ENSG00000176890" "TYMS" "hsa:7298; P04818; Q8WYK3; Q8WYK4" "Fluoropyrimidine activity; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates; G1/S-Specific Transcription" "9" "0" "0.955" "1.095" "0.957" "1.091" "1.124" "1.088" "0.736" "0.969" "4.188" "111.0" "106.0" "121.6" "106.2" "121.1" "124.8" "120.8" "81.6" "107.6" "464.7" "" "" "" "" "" "" "" "" "" "" "58.8" "58.7" "69.6" "48.9" "65.5" "69.4" "71.1" "44.6" "60.4" "464.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8413974576400389324" "False" "High" "IsMasterProtein" "Q9NQT5" "Exosome complex component RRP40 OS=Homo sapiens OX=9606 GN=EXOSC3 PE=1 SV=3" "0.000" "False" "5.789" "8" "1" "1" "1" "275" "29.6" "8.10" "3.79" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf15985, Pf21261, Pf21262" "51010" "ENSG00000107371" "EXOSC3" "A8K0K6; hsa:51010; Q5QP85; Q9NQT5; Q9Y3A8" "" "ATF4 activates genes in response to endoplasmic reticulum stress; Major pathway of rRNA processing in the nucleolus and cytosol; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "6" "0" "1.060" "1.057" "0.711" "0.841" "1.056" "0.904" "1.030" "1.023" "1.149" "38.9" "41.3" "41.1" "27.7" "32.7" "41.1" "35.2" "40.1" "39.8" "44.7" "" "" "" "" "" "" "" "" "" "" "20.6" "22.9" "23.6" "12.7" "17.7" "22.9" "20.7" "21.9" "22.3" "44.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4100918330742864628" "False" "High" "IsMasterProtein" "Q96GK7" "Oxaloacetate tautomerase FAHD2A, mitochondrial OS=Homo sapiens OX=9606 GN=FAHD2A PE=1 SV=1" "0.000" "False" "5.758" "6" "2" "3" "2" "314" "34.6" "8.24" "6.89" "2" "" "" "other molecular function" "Pf01557" "51011" "ENSG00000115042; ENSG00000292086" "FAHD2A" "hsa:51011; Q96GK7; Q9Y3B0" "" "" "0" "0" "0.938" "1.041" "0.956" "1.120" "0.967" "0.981" "0.980" "1.032" "0.636" "521.8" "489.5" "543.4" "498.6" "584.2" "504.7" "512.1" "511.2" "538.2" "331.6" "" "" "" "" "" "" "" "" "" "" "276.3" "271.4" "311.2" "229.6" "316.1" "280.7" "301.4" "279.0" "301.9" "331.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9168897576622990740" "False" "High" "IsMasterProtein" "O43617" "Trafficking protein particle complex subunit 3 OS=Homo sapiens OX=9606 GN=TRAPPC3 PE=1 SV=1" "0.000" "False" "5.757" "10" "2" "3" "2" "180" "20.3" "4.96" "8.96" "2" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04051" "27095" "ENSG00000054116" "TRAPPC3" "A6NDN0; B2RDN2; D3DPS2; hsa:27095; O43617" "" "COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs" "2" "0" "1.123" "1.028" "0.875" "0.975" "1.089" "1.085" "0.928" "1.187" "1.831" "230.0" "258.3" "236.4" "201.2" "224.3" "250.5" "249.5" "213.4" "273.0" "421.0" "" "" "" "" "" "" "" "" "" "" "121.8" "143.2" "135.4" "92.7" "121.4" "139.3" "146.9" "116.5" "153.2" "421.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3480687027944615342" "False" "High" "IsMasterProtein" "Q8NHG8" "E3 ubiquitin-protein ligase ZNRF2 OS=Homo sapiens OX=9606 GN=ZNRF2 PE=1 SV=1" "0.000" "False" "5.747" "5" "1" "2" "1" "242" "24.1" "7.09" "7.64" "1" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13639" "223082" "ENSG00000180233" "ZNRF2" "Q8NHG8" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.205" "1.194" "1.285" "1.378" "1.129" "1.154" "1.070" "1.390" "1.009" "27.9" "33.6" "33.3" "35.8" "38.4" "31.5" "32.2" "29.8" "38.8" "28.1" "" "" "" "" "" "" "" "" "" "" "14.8" "18.6" "19.1" "16.5" "20.8" "17.5" "18.9" "16.3" "21.7" "28.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5314014285931232470" "False" "High" "IsMasterProtein" "P18124" "Large ribosomal subunit protein uL30 OS=Homo sapiens OX=9606 GN=RPL7 PE=1 SV=1" "0.000" "False" "5.738" "9" "2" "4" "2" "248" "29.2" "10.65" "10.05" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00327, Pf08079" "6129" "ENSG00000147604" "RPL7" "A8K504; hsa:6129; P18124; Q15289; Q3KQU0; Q5I0X1; Q6IBM9" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "0.986" "1.051" "1.410" "1.007" "1.090" "0.926" "0.880" "1.010" "0.467" "82.5" "81.3" "86.7" "116.3" "83.1" "89.9" "76.4" "72.6" "83.3" "38.5" "" "" "" "" "" "" "" "" "" "" "43.7" "45.1" "49.6" "53.5" "44.9" "50.0" "44.9" "39.6" "46.8" "38.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8644531714570174079" "False" "High" "IsMasterProtein" "Q8WVM0" "Dimethyladenosine transferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=TFB1M PE=1 SV=1" "0.000" "False" "5.731" "6" "1" "1" "1" "346" "39.5" "9.26" "3.23" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00398" "51106" "ENSG00000029639" "TFB1M" "hsa:51106; Q05DR0; Q8WVM0; Q9Y384" "Energy metabolism; Mitochondrial gene expression" "Transcriptional activation of mitochondrial biogenesis; rRNA modification in the mitochondrion" "4" "0" "1.680" "0.865" "1.492" "1.739" "1.243" "1.812" "1.334" "0.916" "1.188" "15.9" "26.6" "13.7" "23.6" "27.6" "19.7" "28.7" "21.1" "14.5" "18.8" "" "" "" "" "" "" "" "" "" "" "8.4" "14.8" "7.9" "10.9" "14.9" "11.0" "16.9" "11.5" "8.1" "18.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1035023352736906795" "False" "High" "IsMasterProtein" "O00399" "Dynactin subunit 6 OS=Homo sapiens OX=9606 GN=DCTN6 PE=1 SV=1" "0.000" "False" "5.731" "8" "2" "3" "2" "190" "20.7" "6.32" "8.45" "2" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton;other cell component" "other molecular function" "" "10671" "ENSG00000104671" "DCTN6" "B2RAC1; hsa:10671; O00399" "Vasopressin-regulated water reabsorption" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic" "5" "0" "1.008" "1.000" "1.002" "0.878" "0.965" "0.962" "1.002" "1.010" "0.599" "189.7" "191.1" "189.6" "190.0" "166.5" "183.0" "182.4" "190.0" "191.5" "113.7" "" "" "" "" "" "" "" "" "" "" "100.4" "106.0" "108.6" "87.5" "90.1" "101.8" "107.4" "103.7" "107.5" "113.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7904410846819458044" "False" "High" "IsMasterProtein" "Q92796" "Disks large homolog 3 OS=Homo sapiens OX=9606 GN=DLG3 PE=1 SV=2" "0.000" "False" "5.729" "3" "2" "2" "2" "817" "90.3" "7.03" "2.69" "2" "cell adhesion;cell-cell signaling;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00018, Pf00595, Pf00625, Pf10600" "1741" "ENSG00000082458" "DLG3" "B4E0H1; D3DVU5; hsa:1741; Q5JUW6; Q5JUW7; Q92796; Q9ULI8" "Cell lineage map for neuronal differentiation" "Assembly and cell surface presentation of NMDA receptors; RAF/MAP kinase cascade; Neurexins and neuroligins; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Synaptic adhesion-like molecules; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; NrCAM interactions; Activation of Ca-permeable Kainate Receptor" "11" "0" "1.013" "1.019" "0.975" "0.999" "1.047" "1.028" "0.877" "0.871" "0.746" "265.4" "268.9" "270.4" "258.7" "265.2" "278.0" "272.9" "232.8" "231.2" "197.9" "" "" "" "" "" "" "" "" "" "" "140.5" "149.1" "154.9" "119.2" "143.5" "154.6" "160.6" "127.1" "129.7" "197.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2262786275028472849" "False" "High" "IsMasterProtein" "Q9Y421" "Protein FAM32A OS=Homo sapiens OX=9606 GN=FAM32A PE=1 SV=2" "0.000" "False" "5.720" "12" "1" "1" "1" "112" "13.2" "9.99" "4.17" "1" "cell cycle OR cell proliferation;other biological processes" "nucleus" "" "Pf08555" "26017" "ENSG00000105058" "FAM32A" "hsa:26017; Q9BT02; Q9Y421" "" "mRNA Splicing - Major Pathway" "1" "0" "0.898" "0.955" "0.970" "0.952" "0.982" "0.867" "0.946" "0.800" "0.472" "122.5" "110.0" "117.0" "118.8" "116.6" "120.3" "106.2" "115.9" "97.9" "57.8" "" "" "" "" "" "" "" "" "" "" "64.9" "61.0" "67.0" "54.7" "63.1" "66.9" "62.5" "63.3" "54.9" "57.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6553541234872075133" "False" "High" "IsMasterProtein" "Q8N488" "RING1 and YY1-binding protein OS=Homo sapiens OX=9606 GN=RYBP PE=1 SV=2" "0.000" "False" "5.708" "8" "2" "2" "2" "228" "24.8" "9.63" "5.34" "2" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00641, Pf17219" "23429" "ENSG00000163602; ENSG00000281766" "RYBP" "hsa:23429; Q8N488; Q9P2W5; Q9UMW4" "" "Transcriptional Regulation by E2F6; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "2" "0" "1.045" "1.011" "0.927" "0.937" "0.989" "0.990" "1.090" "0.990" "0.628" "281.2" "293.7" "284.2" "260.5" "263.4" "277.9" "278.4" "306.4" "278.3" "176.5" "" "" "" "" "" "" "" "" "" "" "148.9" "162.8" "162.7" "120.0" "142.5" "154.6" "163.9" "167.3" "156.1" "176.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1428811385271777844" "False" "High" "IsMasterProtein" "Q9H488" "GDP-fucose protein O-fucosyltransferase 1 OS=Homo sapiens OX=9606 GN=POFUT1 PE=1 SV=1" "0.000" "False" "5.698" "3" "1" "3" "1" "388" "43.9" "8.53" "7.05" "1" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf10250" "23509" "ENSG00000101346" "POFUT1" "A8K4R8; E1P5M4; hsa:23509; Q14685; Q5W185; Q9BW76; Q9H488" "" "Pre-NOTCH Processing in the Endoplasmic Reticulum" "1" "0" "0.950" "1.043" "1.038" "0.994" "1.018" "0.998" "1.039" "0.951" "0.658" "259.9" "246.9" "271.0" "269.8" "258.4" "264.7" "259.5" "269.9" "247.0" "170.9" "" "" "" "" "" "" "" "" "" "" "137.6" "136.9" "155.2" "124.2" "139.8" "147.2" "152.7" "147.3" "138.6" "170.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2014587900474496052" "False" "High" "IsMasterProtein" "Q9P015" "Large ribosomal subunit protein uL15m OS=Homo sapiens OX=9606 GN=MRPL15 PE=1 SV=1" "0.000" "False" "5.693" "6" "2" "2" "2" "296" "33.4" "10.01" "3.99" "2" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00828" "29088" "ENSG00000137547" "MRPL15" "hsa:29088; Q96Q54; Q9H0Y1; Q9P015" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.059" "0.971" "1.137" "1.154" "0.992" "1.041" "1.115" "1.013" "1.226" "127.8" "135.4" "124.1" "145.3" "147.6" "126.8" "133.1" "142.5" "129.5" "156.8" "" "" "" "" "" "" "" "" "" "" "67.7" "75.0" "71.1" "66.9" "79.8" "70.5" "78.3" "77.8" "72.7" "156.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4572306403840384650" "False" "High" "IsMasterProtein" "O75208" "Ubiquinone biosynthesis protein COQ9, mitochondrial OS=Homo sapiens OX=9606 GN=COQ9 PE=1 SV=1" "0.000" "False" "5.691" "5" "2" "3" "2" "318" "35.5" "5.94" "5.54" "2" "other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf08511, Pf21392" "57017" "ENSG00000088682" "COQ9" "A8K3L2; hsa:57017; O75208; Q7L5V7; Q7Z5T6; Q8NBL4; Q9NTJ2; Q9P056" "" "Ubiquinol biosynthesis" "1" "0" "1.108" "1.070" "1.037" "1.063" "1.060" "1.011" "1.048" "1.051" "0.805" "324.1" "359.1" "346.7" "336.0" "344.6" "343.5" "327.7" "339.7" "340.8" "260.8" "" "" "" "" "" "" "" "" "" "" "171.6" "199.1" "198.6" "154.8" "186.5" "191.1" "192.9" "185.4" "191.2" "260.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6636555355274069790" "False" "High" "IsMasterProtein" "Q9Y5J9" "Mitochondrial import inner membrane translocase subunit Tim8 B OS=Homo sapiens OX=9606 GN=TIMM8B PE=1 SV=1" "0.000" "False" "5.690" "18" "2" "2" "2" "83" "9.3" "5.12" "3.19" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf02953" "26521" "ENSG00000150779" "TIMM8B" "B0YJA5; hsa:26521; Q3KQS9; Q9UN04; Q9Y5J9" "" "Mitochondrial protein import" "1" "0" "1.011" "1.091" "0.984" "0.919" "0.903" "1.001" "1.099" "0.972" "0.660" "146.5" "148.0" "159.8" "144.1" "134.6" "132.3" "146.7" "161.1" "142.4" "96.7" "" "" "" "" "" "" "" "" "" "" "77.6" "82.1" "91.5" "66.4" "72.8" "73.6" "86.3" "87.9" "79.9" "96.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4833705581656825044" "False" "High" "IsMasterProtein" "Q96RT1" "Erbin OS=Homo sapiens OX=9606 GN=ERBIN PE=1 SV=2" "0.000" "False" "5.689" "1" "2" "2" "2" "1412" "158.2" "5.50" "4.93" "2" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "extracellular matrix;plasma membrane;other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity" "Pf00595, Pf13855" "55914" "ENSG00000112851" "ERBIN" "A0AVR1; B4E3F1; B7ZLV9; E7EQW9; E9PCR8; hsa:55914; Q1RMD0; Q86W38; Q96RT1; Q9NR18; Q9NW48; Q9ULJ5" "Nucleotide-binding oligomerization domain (NOD) pathway; Nod-like receptor (NLR) signaling pathway; Pathways affected in adenoid cystic carcinoma" "RHOC GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; Drug-mediated inhibition of ERBB2 signaling; Resistance of ERBB2 KD mutants to trastuzumab; Resistance of ERBB2 KD mutants to sapitinib; Resistance of ERBB2 KD mutants to tesevatinib; Resistance of ERBB2 KD mutants to neratinib; Resistance of ERBB2 KD mutants to osimertinib; Resistance of ERBB2 KD mutants to afatinib; Resistance of ERBB2 KD mutants to AEE788; Resistance of ERBB2 KD mutants to lapatinib; Drug resistance in ERBB2 TMD/JMD mutants" "26" "0" "0.895" "1.005" "0.961" "1.120" "0.997" "1.090" "0.952" "1.115" "0.712" "101.7" "91.1" "102.3" "97.8" "113.9" "101.4" "110.9" "96.8" "113.4" "72.5" "" "" "" "" "" "" "" "" "" "" "53.9" "50.5" "58.6" "45.0" "61.6" "56.4" "65.3" "52.9" "63.6" "72.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5167676998188788346" "False" "High" "IsMasterProtein" "Q96EV2" "RNA-binding protein 33 OS=Homo sapiens OX=9606 GN=RBM33 PE=1 SV=3" "0.000" "False" "5.688" "1" "1" "1" "1" "1170" "129.9" "6.93" "2.64" "1" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "155435" "ENSG00000184863" "RBM33" "A4D244; B5MC24; hsa:155435; Q52LF5; Q75LN9; Q75ML5; Q96EV2; Q9NSV0" "" "" "0" "0" "1.296" "0.999" "1.104" "1.509" "1.254" "1.279" "1.123" "1.207" "2.322" "24.3" "31.5" "24.3" "26.8" "36.6" "30.5" "31.1" "27.3" "29.3" "56.4" "" "" "" "" "" "" "" "" "" "" "12.9" "17.5" "13.9" "12.3" "19.8" "16.9" "18.3" "14.9" "16.4" "56.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5828949100496623215" "False" "High" "IsMasterProtein" "Q92844" "TRAF family member-associated NF-kappa-B activator OS=Homo sapiens OX=9606 GN=TANK PE=1 SV=2" "0.000" "False" "5.674" "3" "1" "2" "1" "425" "47.8" "5.68" "6.06" "1" "stress response;signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf12845" "10010" "ENSG00000136560" "TANK" "D3DPB5; hsa:10010; Q7Z4J6; Q92844; Q92885" "TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Novel intracellular components of RIG-I-like receptor pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "Activation of IRF3, IRF7 mediated by TBK1, IKBKE; TICAM1-dependent activation of IRF3/IRF7; TRAF6 mediated IRF7 activation" "7" "0" "0.982" "0.988" "1.005" "0.935" "0.861" "1.020" "0.889" "0.925" "1.319" "133.5" "131.1" "132.0" "134.3" "124.8" "114.9" "136.2" "118.8" "123.5" "176.2" "" "" "" "" "" "" "" "" "" "" "70.7" "72.7" "75.6" "61.8" "67.5" "63.9" "80.1" "64.8" "69.3" "176.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3150532128508731386" "False" "High" "IsMasterProtein" "O75554" "WW domain-binding protein 4 OS=Homo sapiens OX=9606 GN=WBP4 PE=1 SV=1" "0.000" "False" "5.663" "5" "2" "3" "2" "376" "42.5" "5.57" "8.64" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00397, Pf06220" "11193" "ENSG00000120688" "WBP4" "B7Z4M2; hsa:11193; O75554; Q32P29" "" "mRNA Splicing - Major Pathway" "1" "0" "0.981" "1.067" "1.018" "1.030" "0.922" "0.987" "1.107" "1.008" "0.500" "1005.2" "986.0" "1073.0" "1023.0" "1035.5" "926.8" "992.6" "1113.2" "1013.4" "502.6" "" "" "" "" "" "" "" "" "" "" "532.3" "546.6" "614.5" "471.1" "560.2" "515.5" "584.2" "607.7" "568.5" "502.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2229585917492551052" "False" "High" "IsMasterProtein" "P53992" "Protein transport protein Sec24C OS=Homo sapiens OX=9606 GN=SEC24C PE=1 SV=3" "0.000" "False" "5.657" "1" "1" "1" "1" "1094" "118.2" "7.06" "3.48" "1" "cell organization and biogenesis;transport;developmental processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "9632" "ENSG00000176986" "SEC24C" "B4DZT4; hsa:9632; P53992; Q8WV25" "Sterol regulatory element-binding proteins (SREBP) signaling" "COPII-mediated vesicle transport; MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6716133539155154712" "False" "High" "IsMasterProtein" "P82650" "Small ribosomal subunit protein mS22 OS=Homo sapiens OX=9606 GN=MRPS22 PE=1 SV=1" "0.000" "False" "5.638" "3" "1" "1" "1" "360" "41.3" "7.90" "3.51" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf10245" "56945" "ENSG00000175110" "MRPS22" "hsa:56945; P82650; Q9H3I1" "Primary ovarian insufficiency" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "1.038" "1.143" "1.088" "0.942" "1.053" "0.806" "0.590" "0.908" "6.551" "109.2" "113.3" "124.8" "118.8" "102.8" "115.0" "88.0" "64.5" "99.1" "715.2" "" "" "" "" "" "" "" "" "" "" "57.8" "62.8" "71.4" "54.7" "55.6" "63.9" "51.8" "35.2" "55.6" "715.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-323839447441261697" "False" "High" "IsMasterProtein" "Q9NWK9" "Box C/D snoRNA protein 1 OS=Homo sapiens OX=9606 GN=ZNHIT6 PE=1 SV=1" "0.000" "False" "5.634" "6" "3" "3" "3" "470" "53.9" "5.80" "8.06" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04438" "54680" "ENSG00000117174" "ZNHIT6" "B2RBA1; B4DP13; D3DT20; hsa:54680; Q9H278; Q9H3X3; Q9NWK9; Q9NWN0" "" "" "0" "0" "1.090" "1.085" "1.342" "1.143" "1.016" "1.214" "1.084" "1.136" "2.209" "104.4" "113.7" "113.3" "140.1" "119.3" "106.1" "126.7" "113.1" "118.6" "230.6" "" "" "" "" "" "" "" "" "" "" "55.3" "63.0" "64.9" "64.5" "64.5" "59.0" "74.6" "61.8" "66.5" "230.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1389983804562693885" "False" "High" "IsMasterProtein" "A2RUC4" "tRNA wybutosine-synthesizing protein 5 OS=Homo sapiens OX=9606 GN=TYW5 PE=1 SV=1" "0.000" "False" "5.629" "9" "3" "3" "3" "315" "36.5" "7.55" "6.21" "3" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf13621" "129450" "ENSG00000162971" "TYW5" "A2RUC4; B2RNE3; hsa:129450; Q8N1R2" "" "Synthesis of wybutosine at G37 of tRNA(Phe)" "1" "0" "1.398" "1.436" "1.272" "1.157" "1.552" "1.277" "0.918" "1.324" "0.944" "32.7" "45.7" "47.0" "41.6" "37.9" "50.8" "41.8" "30.0" "43.3" "30.9" "" "" "" "" "" "" "" "" "" "" "17.3" "25.3" "26.9" "19.2" "20.5" "28.2" "24.6" "16.4" "24.3" "30.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8397270974056062959" "False" "High" "IsMasterProtein" "Q9NRL3" "Striatin-4 OS=Homo sapiens OX=9606 GN=STRN4 PE=1 SV=2" "0.000" "False" "5.625" "2" "1" "1" "1" "753" "80.5" "5.40" "4.30" "1" "" "other membranes;other cell component" "other molecular function" "Pf00400, Pf08232" "29888" "ENSG00000090372" "STRN4" "A0A024R0V2; B4DQH7; F8VYA6; hsa:29888; Q8NE53; Q9NRL3" "" "" "0" "0" "1.123" "1.143" "1.454" "1.075" "1.411" "1.480" "1.282" "1.193" "1.227" "58.0" "65.1" "66.3" "84.3" "62.3" "81.9" "85.8" "74.3" "69.2" "71.2" "" "" "" "" "" "" "" "" "" "" "30.7" "36.1" "38.0" "38.8" "33.7" "45.5" "50.5" "40.6" "38.8" "71.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8976168612742678464" "False" "High" "IsMasterProtein" "Q13243" "Serine/arginine-rich splicing factor 5 OS=Homo sapiens OX=9606 GN=SRSF5 PE=1 SV=1" "0.000" "False" "5.621" "6" "2" "5" "1" "272" "31.2" "11.59" "13.14" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "" "Pf00076" "6430" "ENSG00000100650" "SRSF5" "hsa:6430; O14797; Q13243; Q16662; Q49AD6; Q6FGE0" "mRNA processing" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "6" "0" "1.105" "1.057" "1.074" "1.079" "1.077" "1.376" "1.090" "1.111" "0.718" "86.1" "95.1" "91.0" "92.5" "92.9" "92.7" "118.5" "93.8" "95.7" "61.9" "" "" "" "" "" "" "" "" "" "" "45.6" "52.7" "52.1" "42.6" "50.3" "51.6" "69.7" "51.2" "53.7" "61.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3946386613732823747" "False" "High" "IsMasterProtein" "Q8WXD5" "Gem-associated protein 6 OS=Homo sapiens OX=9606 GN=GEMIN6 PE=1 SV=1" "0.000" "False" "5.620" "14" "2" "3" "2" "167" "18.8" "5.12" "8.74" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf06372, Pf20417" "79833" "ENSG00000152147" "GEMIN6" "B2RDP8; hsa:79833; Q53SI5; Q8WVB4; Q8WXD5; Q9H5G6" "" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "2" "0" "1.087" "1.057" "1.309" "0.994" "1.183" "1.038" "0.956" "1.081" "0.893" "61.0" "66.3" "64.5" "79.8" "60.6" "72.2" "63.3" "58.3" "66.0" "54.5" "" "" "" "" "" "" "" "" "" "" "32.3" "36.8" "36.9" "36.8" "32.8" "40.2" "37.3" "31.8" "37.0" "54.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8414928618058390258" "False" "High" "IsMasterProtein" "Q8N9N2" "Activating signal cointegrator 1 complex subunit 1 OS=Homo sapiens OX=9606 GN=ASCC1 PE=1 SV=1" "0.000" "False" "5.620" "4" "2" "3" "2" "400" "45.5" "5.54" "7.76" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00013, Pf10469" "51008" "ENSG00000138303" "ASCC1" "hsa:51008; Q5SW06; Q5SW07; Q8N9N2; Q96EI8; Q9Y307" "Neuroinflammation" "ALKBH3 mediated reversal of alkylation damage" "2" "0" "1.056" "0.925" "1.161" "1.115" "1.127" "0.987" "1.047" "1.259" "1.085" "112.2" "118.4" "103.7" "130.2" "125.0" "126.4" "110.7" "117.5" "141.3" "121.7" "" "" "" "" "" "" "" "" "" "" "59.4" "65.6" "59.4" "60.0" "67.7" "70.3" "65.2" "64.1" "79.2" "121.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5258302069466510735" "False" "High" "IsMasterProtein" "P56279" "T-cell leukemia/lymphoma protein 1A OS=Homo sapiens OX=9606 GN=TCL1A PE=1 SV=1" "0.000" "False" "5.611" "13" "2" "4" "2" "114" "13.5" "5.11" "11.57" "2" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01840" "8115" "ENSG00000100721" "TCL1A" "hsa:8115; P56279; Q6IBK7" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "" "2" "0" "0.916" "0.943" "0.940" "0.935" "0.968" "0.932" "0.948" "0.919" "0.631" "1172.4" "1073.6" "1106.1" "1102.0" "1095.6" "1134.5" "1092.7" "1111.7" "1077.6" "739.7" "" "" "" "" "" "" "" "" "" "" "620.8" "595.2" "633.5" "507.5" "592.8" "631.1" "643.1" "606.8" "604.5" "739.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6251688870276858346" "False" "High" "IsMasterProtein" "Q9BX40" "Protein LSM14 homolog B OS=Homo sapiens OX=9606 GN=LSM14B PE=1 SV=1" "0.000" "False" "5.606" "6" "2" "2" "1" "385" "42.0" "9.69" "2.46" "2" "other biological processes" "other cell component" "nucleic acid binding activity" "Pf09532, Pf12701" "149986" "ENSG00000149657" "LSM14B" "hsa:149986; Q6PFW8; Q96LH8; Q9BX40" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6501697818920195355" "False" "High" "IsMasterProtein" "Q9Y3B9" "RRP15-like protein OS=Homo sapiens OX=9606 GN=RRP15 PE=1 SV=2" "0.000" "False" "5.599" "9" "2" "2" "2" "282" "31.5" "5.52" "5.25" "2" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "" "Pf07890" "51018" "ENSG00000067533" "RRP15" "hsa:51018; Q9Y3B9" "" "" "0" "0" "1.157" "1.235" "1.066" "1.161" "1.065" "1.234" "1.350" "1.171" "0.347" "173.9" "201.1" "214.7" "185.4" "201.8" "185.1" "214.5" "234.7" "203.6" "60.4" "" "" "" "" "" "" "" "" "" "" "92.1" "111.5" "123.0" "85.4" "109.2" "103.0" "126.2" "128.1" "114.2" "60.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1663461843225663368" "False" "High" "IsMasterProtein" "O00716" "Transcription factor E2F3 OS=Homo sapiens OX=9606 GN=E2F3 PE=1 SV=1" "0.000" "False" "5.596" "4" "2" "2" "2" "465" "49.1" "5.44" "5.15" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02319, Pf16421" "1871" "ENSG00000112242" "E2F3" "hsa:1871; O00716; Q15000; Q68DT0; Q9BZ44" "Cell cycle; Metastatic brain tumor; B cell receptor signaling pathway; Retinoblastoma gene in cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; G1 to S cell cycle control; Small cell lung cancer; Melanoma; Nephrotic syndrome" "Oxidative Stress Induced Senescence; Pre-NOTCH Transcription and Translation; Oncogene Induced Senescence; G2 Phase; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)" "17" "0" "1.037" "1.046" "1.188" "1.130" "1.016" "1.108" "1.069" "1.134" "1.064" "201.3" "208.7" "210.5" "239.0" "227.5" "204.4" "223.0" "215.2" "228.3" "214.3" "" "" "" "" "" "" "" "" "" "" "106.6" "115.7" "120.6" "110.1" "123.1" "113.7" "131.3" "117.4" "128.1" "214.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2769790673461720299" "False" "High" "IsMasterProtein" "Q96DF8" "Splicing factor ESS-2 homolog OS=Homo sapiens OX=9606 GN=ESS2 PE=1 SV=1" "0.000" "False" "5.586" "6" "3" "3" "3" "476" "52.5" "7.56" "7.43" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "" "Pf09751" "8220" "ENSG00000100056" "ESS2" "hsa:8220; Q49AH7; Q96DF8; Q9BTZ4" "22q11.2 copy number variation syndrome" "" "1" "0" "1.140" "1.074" "1.092" "1.010" "1.073" "1.102" "1.233" "1.121" "1.059" "217.5" "247.9" "233.6" "237.5" "219.8" "233.4" "239.6" "268.3" "243.9" "230.3" "" "" "" "" "" "" "" "" "" "" "115.2" "137.5" "133.8" "109.4" "118.9" "129.8" "141.0" "146.4" "136.8" "230.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-911938199932515837" "False" "High" "IsMasterProtein" "Q9NZQ3" "NCK-interacting protein with SH3 domain OS=Homo sapiens OX=9606 GN=NCKIPSD PE=1 SV=1" "0.000" "False" "5.570" "3" "2" "2" "2" "722" "78.9" "6.38" "4.65" "2" "cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00018, Pf09431" "51517" "ENSG00000213672" "NCKIPSD" "B4DFL5; hsa:51517; Q6GU34; Q6SPF3; Q8TC10; Q9NZQ3; Q9UGM8" "" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs" "3" "0" "1.052" "0.824" "1.306" "1.020" "1.174" "1.278" "0.729" "1.079" "3.836" "65.4" "68.8" "53.9" "85.4" "66.7" "76.8" "83.6" "47.7" "70.6" "250.8" "" "" "" "" "" "" "" "" "" "" "34.6" "38.1" "30.9" "39.3" "36.1" "42.7" "49.2" "26.0" "39.6" "250.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2566135857611723126" "False" "High" "IsMasterProtein" "P23743" "Diacylglycerol kinase alpha OS=Homo sapiens OX=9606 GN=DGKA PE=1 SV=3" "0.000" "False" "5.568" "4" "3" "3" "3" "735" "82.6" "6.73" "4.24" "3" "other metabolic processes;stress response;signal transduction" "plasma membrane;other membranes;cytosol" "kinase activity;other molecular function" "Pf00130, Pf00609, Pf00781, Pf14513" "1606" "ENSG00000065357" "DGKA" "hsa:1606; O75481; O75482; O75483; O95217; P23743; Q3ZE25; Q8IZ56; Q8N5Q2" "Modulators of TCR signaling and T cell activation" "Effects of PIP2 hydrolysis" "2" "0" "0.886" "0.993" "1.003" "1.019" "0.966" "1.072" "0.479" "0.735" "3.405" "82.9" "73.4" "82.3" "83.1" "84.5" "80.1" "88.9" "39.7" "60.9" "282.2" "" "" "" "" "" "" "" "" "" "" "43.9" "40.7" "47.2" "38.3" "45.7" "44.5" "52.3" "21.7" "34.2" "282.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-768881656379736442" "False" "High" "IsMasterProtein" "Q9BT73" "Proteasome assembly chaperone 3 OS=Homo sapiens OX=9606 GN=PSMG3 PE=1 SV=1" "0.000" "False" "5.556" "11" "1" "3" "1" "122" "13.1" "7.88" "5.50" "1" "cell organization and biogenesis" "other cell component" "other molecular function" "Pf10178" "84262" "ENSG00000157778" "PSMG3" "A4D216; A8MPW2; hsa:84262; Q9BT73" "" "" "0" "0" "1.573" "1.088" "1.879" "1.339" "1.360" "1.462" "1.034" "1.137" "1.060" "34.1" "53.7" "37.1" "64.1" "45.7" "46.4" "49.9" "35.3" "38.8" "36.2" "" "" "" "" "" "" "" "" "" "" "18.1" "29.8" "21.2" "29.5" "24.7" "25.8" "29.4" "19.3" "21.8" "36.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4230777369959258810" "False" "High" "IsMasterProtein" "O95239" "Chromosome-associated kinesin KIF4A OS=Homo sapiens OX=9606 GN=KIF4A PE=1 SV=3" "0.000" "False" "5.555" "2" "2" "2" "2" "1232" "139.8" "6.27" "2.87" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00225" "24137" "ENSG00000090889" "KIF4A" "B2R7V5; D3DVU4; hsa:24137; O95239; Q86TN3; Q86XX7; Q9NNY6; Q9NY24; Q9UMW3" "Retinoblastoma gene in cancer" "Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5153257351632709387" "False" "High" "IsMasterProtein" "P26374" "Rab proteins geranylgeranyltransferase component A 2 OS=Homo sapiens OX=9606 GN=CHML PE=1 SV=2" "0.000" "False" "5.552" "3" "2" "2" "2" "656" "74.0" "4.93" "5.61" "2" "protein metabolism;other metabolic processes;transport;signal transduction" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "1122" "ENSG00000203668" "CHML" "B2RAB9; hsa:1122; P26374; Q17RE0; Q9H1Y4" "" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation" "2" "0" "1.044" "1.007" "1.061" "1.114" "1.077" "1.169" "1.180" "1.001" "0.758" "233.0" "243.2" "234.5" "247.1" "259.5" "250.9" "272.3" "275.0" "233.2" "176.5" "" "" "" "" "" "" "" "" "" "" "123.4" "134.8" "134.3" "113.8" "140.4" "139.6" "160.3" "150.1" "130.8" "176.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4847329680640326989" "False" "High" "IsMasterProtein" "Q8NDI1" "EH domain-binding protein 1 OS=Homo sapiens OX=9606 GN=EHBP1 PE=1 SV=3" "0.000" "False" "5.551" "1" "2" "2" "2" "1231" "139.9" "5.35" "5.11" "2" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle" "" "Pf00307, Pf10358, Pf12130" "23301" "ENSG00000115504" "EHBP1" "hsa:23301; O94977; Q53TG7; Q53TV6; Q580X2; Q6NX72; Q6PIT3; Q6QNV2; Q8NDI1; Q9NWI9" "Ciliary landscape" "" "1" "0" "0.919" "0.845" "0.855" "1.131" "0.877" "1.138" "1.154" "1.183" "1.082" "167.2" "153.7" "141.2" "142.9" "189.1" "146.7" "190.2" "192.9" "197.9" "180.8" "" "" "" "" "" "" "" "" "" "" "88.5" "85.2" "80.9" "65.8" "102.3" "81.6" "112.0" "105.3" "111.0" "180.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6451212714764409168" "False" "High" "IsMasterProtein" "Cont_A0A3Q1M3L6" "Uncharacterized protein OS=Bos taurus OX=9913 PE=1 SV=1" "0.000" "True" "5.530" "3" "1" "1" "1" "367" "40.5" "5.34" "3.86" "1" "stress response;other biological processes" "non-structural extracellular;other membranes" "signal transduction activity or receptor binding;other molecular function" "Pf07654" "" "" "" "" "" "Initial triggering of complement; Classical antibody-mediated complement activation; Regulation of Complement cascade; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; FCGR activation" "6" "0" "0.996" "1.166" "1.320" "1.097" "1.233" "1.027" "1.048" "1.054" "0.858" "80.5" "80.2" "93.8" "106.2" "88.3" "99.2" "82.6" "84.4" "84.8" "69.1" "" "" "" "" "" "" "" "" "" "" "42.6" "44.5" "53.7" "48.9" "47.8" "55.2" "48.6" "46.0" "47.6" "69.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4477032751293866758" "False" "High" "IsMasterProtein" "Q96MF7" "E3 SUMO-protein ligase NSE2 OS=Homo sapiens OX=9606 GN=NSMCE2 PE=1 SV=2" "0.000" "False" "5.524" "4" "1" "1" "1" "247" "27.9" "7.74" "3.66" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11789" "286053" "ENSG00000156831" "NSMCE2" "hsa:286053; Q8N549; Q96MF7" "" "SUMOylation of DNA damage response and repair proteins" "1" "0" "1.110" "1.051" "1.085" "1.009" "0.960" "1.191" "1.266" "1.132" "1.628" "59.2" "65.7" "62.2" "64.3" "59.7" "56.8" "70.5" "75.0" "67.0" "96.4" "" "" "" "" "" "" "" "" "" "" "31.3" "36.4" "35.6" "29.6" "32.3" "31.6" "41.5" "40.9" "37.6" "96.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3778187452605941811" "False" "High" "IsMasterProtein" "Q9NZ52" "ADP-ribosylation factor-binding protein GGA3 OS=Homo sapiens OX=9606 GN=GGA3 PE=1 SV=1" "0.000" "False" "5.520" "3" "2" "2" "2" "723" "78.3" "5.58" "4.95" "2" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf02883, Pf03127, Pf18308" "23163" "ENSG00000125447" "GGA3" "B7Z7E2; B7Z7M9; hsa:23163; J3KRN0; Q15017; Q6IS16; Q9NZ52; Q9UJY3" "" "Amyloid fiber formation; TBC/RABGAPs; MET receptor recycling" "3" "0" "1.046" "1.217" "1.144" "0.979" "1.177" "1.568" "1.792" "1.551" "2.206" "63.4" "66.4" "77.2" "72.5" "62.1" "74.7" "99.4" "113.6" "98.4" "139.9" "" "" "" "" "" "" "" "" "" "" "33.6" "36.8" "44.2" "33.4" "33.6" "41.5" "58.5" "62.0" "55.2" "139.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6657686065862137180" "False" "High" "IsMasterProtein" "Q9Y371" "Endophilin-B1 OS=Homo sapiens OX=9606 GN=SH3GLB1 PE=1 SV=1" "0.000" "False" "5.519" "4" "2" "2" "1" "365" "40.8" "6.04" "5.87" "2" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03114, Pf14604" "51100" "ENSG00000097033" "SH3GLB1" "B4E182; hsa:51100; Q5H8U5; Q9H3Z0; Q9NR47; Q9NYA9; Q9Y371" "Nanoparticle triggered autophagic cell death" "" "1" "0" "0.880" "1.108" "1.080" "1.245" "0.961" "1.294" "0.892" "0.964" "5.436" "41.5" "36.6" "46.0" "44.9" "51.7" "39.9" "53.8" "37.0" "40.1" "225.8" "" "" "" "" "" "" "" "" "" "" "22.0" "20.3" "26.4" "20.7" "28.0" "22.2" "31.6" "20.2" "22.5" "225.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "307320246962858459" "False" "High" "IsMasterProtein" "Q6UWZ7" "BRCA1-A complex subunit Abraxas 1 OS=Homo sapiens OX=9606 GN=ABRAXAS1 PE=1 SV=2" "0.000" "False" "5.517" "4" "2" "2" "2" "409" "46.6" "7.05" "5.80" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "cytoskeletal activity;other molecular function" "Pf21125" "84142" "ENSG00000163322" "ABRAXAS1" "A5JJ07; hsa:84142; Q6UWZ7; Q9H8I1; Q9H9N4" "5q35 copy number variation" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; Metalloprotease DUBs; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "6" "0" "1.091" "1.085" "1.129" "1.116" "1.068" "1.213" "1.206" "1.279" "0.849" "233.2" "254.3" "253.1" "263.3" "260.2" "249.0" "282.8" "281.1" "298.2" "197.9" "" "" "" "" "" "" "" "" "" "" "123.5" "141.0" "144.9" "121.2" "140.8" "138.5" "166.4" "153.5" "167.3" "197.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8527831482180649662" "False" "High" "IsMasterProtein" "Q8NCE2" "Myotubularin-related protein 14 OS=Homo sapiens OX=9606 GN=MTMR14 PE=1 SV=2" "0.000" "False" "5.511" "2" "1" "1" "1" "650" "72.2" "6.24" "2.86" "1" "other metabolic processes" "cytosol;other cell component" "other molecular function" "" "64419" "ENSG00000163719" "MTMR14" "hsa:64419; Q0JTH5; Q0JU83; Q6PIZ4; Q6QE21; Q86VK9; Q8IYK1; Q8NCE2; Q8TCM7; Q9H6C0" "" "Synthesis of PIPs at the plasma membrane; Macroautophagy" "2" "0" "0.968" "1.097" "0.956" "0.981" "0.953" "0.986" "0.851" "0.977" "1.558" "112.4" "108.8" "123.3" "107.4" "110.3" "107.1" "110.8" "95.6" "109.8" "175.1" "" "" "" "" "" "" "" "" "" "" "59.5" "60.3" "70.6" "49.5" "59.7" "59.6" "65.2" "52.2" "61.6" "175.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4925331307854051957" "False" "High" "IsMasterProtein" "Q14739" "Delta(14)-sterol reductase LBR OS=Homo sapiens OX=9606 GN=LBR PE=1 SV=2" "0.000" "False" "5.508" "3" "2" "3" "2" "615" "70.7" "9.36" "8.78" "2" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01222, Pf09465" "3930" "ENSG00000143815" "LBR" "B2R5P3; hsa:3930; Q14739; Q14740; Q53GU7; Q59FE6" "Gastric cancer network 2; Envelope proteins and their potential roles in EDMD physiopathology; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; Regulation of MECP2 expression and activity; Initiation of Nuclear Envelope (NE) Reformation; Cholesterol biosynthesis" "18" "0" "1.042" "1.011" "1.208" "1.235" "1.329" "1.148" "1.166" "1.165" "1.297" "263.7" "274.8" "266.5" "318.5" "325.6" "350.4" "302.8" "307.4" "307.1" "342.1" "" "" "" "" "" "" "" "" "" "" "139.6" "152.4" "152.6" "146.7" "176.2" "194.9" "178.2" "167.8" "172.3" "342.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5043456387620106594" "False" "High" "IsMasterProtein" "Q86US8" "Telomerase-binding protein EST1A OS=Homo sapiens OX=9606 GN=SMG6 PE=1 SV=2" "0.000" "False" "5.488" "1" "2" "2" "2" "1419" "160.4" "7.05" "5.46" "2" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10373, Pf10374, Pf13638" "23293" "ENSG00000070366" "SMG6" "B7Z874; hsa:23293; O94837; Q86US8; Q86VH6; Q9UF60" "" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "1" "0" "0.896" "1.062" "1.518" "1.640" "1.414" "2.040" "1.942" "2.164" "1.317" "117.4" "105.2" "124.7" "178.2" "192.5" "166.0" "239.5" "228.0" "254.0" "154.6" "" "" "" "" "" "" "" "" "" "" "62.2" "58.3" "71.4" "82.1" "104.2" "92.3" "140.9" "124.5" "142.5" "154.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3659608677254824690" "False" "High" "IsMasterProtein" "P53582" "Methionine aminopeptidase 1 OS=Homo sapiens OX=9606 GN=METAP1 PE=1 SV=2" "0.000" "False" "5.487" "3" "1" "2" "1" "386" "43.2" "7.17" "4.65" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00557, Pf15801" "23173" "ENSG00000164024" "METAP1" "B4E2E6; hsa:23173; P53582" "" "Inactivation, recovery and regulation of the phototransduction cascade" "1" "0" "1.086" "0.948" "1.265" "1.147" "1.030" "1.013" "1.028" "1.293" "0.770" "114.0" "123.8" "108.0" "144.2" "130.8" "117.4" "115.5" "117.2" "147.4" "87.8" "" "" "" "" "" "" "" "" "" "" "60.4" "68.6" "61.9" "66.4" "70.8" "65.3" "68.0" "64.0" "82.7" "87.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4573185288358324905" "False" "High" "IsMasterProtein" "P21953" "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=BCKDHB PE=1 SV=2" "0.000" "False" "5.468" "5" "2" "3" "2" "392" "43.1" "6.29" "8.54" "2" "other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf02779, Pf02780" "594" "ENSG00000083123" "BCKDHB" "hsa:594; P21953; Q5T2J3; Q9BQL0" "Primary ovarian insufficiency" "Glyoxylate metabolism and glycine degradation; Branched-chain amino acid catabolism" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4593935513655895610" "False" "High" "IsMasterProtein" "Q13614" "Myotubularin-related protein 2 OS=Homo sapiens OX=9606 GN=MTMR2 PE=1 SV=4" "0.000" "False" "5.451" "4" "3" "3" "3" "643" "73.3" "7.40" "7.18" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02893, Pf06602" "8898" "ENSG00000087053" "MTMR2" "A6NN98; hsa:8898; Q13614; Q9UPS9" "Intracellular trafficking proteins involved in CMT neuropathy" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; Synthesis of PIPs at the ER membrane" "5" "0" "1.039" "0.982" "1.385" "1.157" "1.066" "1.044" "0.964" "0.906" "0.934" "59.0" "61.3" "57.9" "81.7" "68.2" "62.9" "61.6" "56.9" "53.5" "55.1" "" "" "" "" "" "" "" "" "" "" "31.2" "34.0" "33.2" "37.6" "36.9" "35.0" "36.3" "31.0" "30.0" "55.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6980948205033410350" "False" "High" "IsMasterProtein" "Q8WXI9" "Transcriptional repressor p66-beta OS=Homo sapiens OX=9606 GN=GATAD2B PE=1 SV=1" "0.000" "False" "5.446" "4" "2" "2" "2" "593" "65.2" "9.70" "5.08" "2" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00320, Pf16563" "57459" "ENSG00000143614; ENSG00000261992" "GATAD2B" "D3DUZ2; hsa:57459; Q5VUR2; Q7LG68; Q8WXI9; Q9ULS0" "" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "6" "0" "0.885" "1.068" "1.098" "0.941" "1.014" "1.331" "1.222" "1.402" "2.386" "67.8" "60.0" "72.5" "74.5" "63.9" "68.8" "90.3" "82.9" "95.1" "161.9" "" "" "" "" "" "" "" "" "" "" "35.9" "33.3" "41.5" "34.3" "34.5" "38.2" "53.1" "45.2" "53.3" "161.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6974141516308557016" "False" "High" "IsMasterProtein" "Q969T9" "WW domain-binding protein 2 OS=Homo sapiens OX=9606 GN=WBP2 PE=1 SV=1" "0.000" "False" "5.444" "8" "2" "2" "2" "261" "28.1" "5.91" "5.73" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02893" "23558" "ENSG00000132471" "WBP2" "B4DFG2; O95638; Q969T9" "" "" "0" "0" "0.925" "1.027" "0.931" "1.019" "0.970" "0.964" "1.019" "0.906" "0.706" "474.6" "438.8" "487.3" "441.7" "483.4" "460.4" "457.6" "483.6" "430.2" "334.9" "" "" "" "" "" "" "" "" "" "" "251.3" "243.3" "279.0" "203.4" "261.6" "256.1" "269.3" "264.0" "241.3" "334.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7098201232450387464" "False" "High" "IsMasterProtein" "Q8N999" "RNA ligase 1 OS=Homo sapiens OX=9606 GN=RLIG1 PE=1 SV=2" "0.000" "False" "5.442" "6" "2" "2" "2" "325" "37.5" "7.06" "2.79" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "" "other molecular function" "Pf17720" "91298" "ENSG00000133641" "RLIG1" "Q569K5; Q6AWA8; Q6PEK5; Q8IYQ5; Q8N999; Q9NT75" "" "" "0" "0" "1.069" "0.850" "0.931" "1.073" "0.948" "1.039" "1.024" "0.943" "0.778" "132.5" "141.7" "112.7" "123.4" "142.3" "125.7" "137.6" "135.8" "124.9" "103.1" "" "" "" "" "" "" "" "" "" "" "70.2" "78.6" "64.5" "56.8" "77.0" "69.9" "81.0" "74.1" "70.1" "103.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3811066710026793793" "False" "High" "IsMasterProtein" "P21580" "Tumor necrosis factor alpha-induced protein 3 OS=Homo sapiens OX=9606 GN=TNFAIP3 PE=1 SV=1" "0.000" "False" "5.441" "3" "3" "3" "3" "790" "89.6" "8.22" "7.11" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01754, Pf02338" "7128" "ENSG00000118503" "TNFAIP3" "B2R767; E1P588; hsa:7128; P21580; Q2HIX9; Q5VXQ7; Q9NSR6" "TNF-alpha signaling pathway; Vitamin D receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Measles virus infection; IL-18 signaling pathway; Burn wound healing; Modulators of TCR signaling and T cell activation" "NOD1/2 Signaling Pathway; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; Negative regulators of DDX58/IFIH1 signaling; Ovarian tumor domain proteases; TNFR1-induced proapoptotic signaling" "14" "0" "0.896" "1.027" "0.986" "0.835" "0.904" "0.927" "0.911" "0.813" "0.799" "101.1" "90.6" "103.9" "99.7" "84.4" "91.4" "93.8" "92.1" "82.3" "80.8" "" "" "" "" "" "" "" "" "" "" "53.6" "50.2" "59.5" "45.9" "45.7" "50.9" "55.2" "50.3" "46.1" "80.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3962544923963048156" "False" "High" "IsMasterProtein" "Q9Y243" "RAC-gamma serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=AKT3 PE=1 SV=1" "0.000" "False" "5.434" "4" "2" "2" "2" "479" "55.7" "6.02" "5.49" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00169, Pf00433" "10000" "ENSG00000117020; ENSG00000275199" "AKT3" "hsa:10000; Q0VAA6; Q5VTI1; Q5VTI2; Q96QV3; Q9UFP5; Q9Y243" "Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; S1P receptor signal transduction; Focal adhesion; Overview of nanoparticle effects; MAPK signaling pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Lipid metabolism pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Nonalcoholic fatty liver disease; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Synaptic signaling pathways associated with autism spectrum disorder; Neural crest cell migration during development; Neural crest cell migration in cancer; Translation inhibitors in chronically activated PDGFRA cells; Small cell lung cancer; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Pleural mesothelioma; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; Sildenafil treatment; JAK-STAT signaling in the regulation of beta cells; Osteoarthritic chondrocyte hypertrophy; Artemisinin inhibition of uveal melanoma; ErbB signaling pathway; Toll-like receptor signaling pathway" "Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; Regulation of TP53 Degradation; Downregulation of ERBB2:ERBB3 signaling; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry; RAB GEFs exchange GTP for GDP on RABs; AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of localization of FOXO transcription factors; CD28 dependent PI3K/Akt signaling; TP53 Regulates Metabolic Genes; G beta:gamma signalling through PI3Kgamma; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; AKT phosphorylates targets in the cytosol; Regulation of TP53 Activity through Association with Co-factors; VEGFR2 mediated vascular permeability; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; FLT3 Signaling; Negative regulation of the PI3K/AKT network; Regulation of TP53 Activity through Acetylation; RUNX2 regulates genes involved in cell migration; CTLA4 inhibitory signaling; Activation of BAD and translocation to mitochondria ; AKT-mediated inactivation of FOXO1A" "70" "0" "0.898" "0.908" "0.909" "0.933" "0.942" "0.918" "0.906" "0.927" "0.828" "283.8" "255.0" "257.6" "257.9" "264.7" "267.2" "260.5" "257.0" "263.1" "234.9" "" "" "" "" "" "" "" "" "" "" "150.3" "141.4" "147.5" "118.8" "143.2" "148.6" "153.3" "140.3" "147.6" "234.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5064408970215960207" "False" "High" "IsMasterProtein" "Q9C0H2" "Protein tweety homolog 3 OS=Homo sapiens OX=9606 GN=TTYH3 PE=1 SV=3" "0.000" "False" "5.419" "3" "2" "2" "2" "523" "57.5" "5.39" "5.47" "2" "transport" "plasma membrane;other membranes" "transporter activity" "Pf04906" "80727" "ENSG00000136295" "TTYH3" "A4D201; B7WP98; hsa:80727; Q6L749; Q6ZVG3; Q8TEG6; Q9C0H2" "" "Stimuli-sensing channels" "1" "0" "0.913" "0.883" "1.109" "1.083" "1.020" "1.198" "0.921" "0.958" "0.864" "206.5" "188.6" "182.3" "229.0" "223.6" "210.7" "247.5" "190.1" "197.8" "178.3" "" "" "" "" "" "" "" "" "" "" "109.3" "104.6" "104.4" "105.5" "121.0" "117.2" "145.6" "103.8" "111.0" "178.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8559290960834017297" "False" "High" "IsMasterProtein" "O14976" "Cyclin-G-associated kinase OS=Homo sapiens OX=9606 GN=GAK PE=1 SV=2" "0.000" "False" "5.417" "2" "2" "2" "2" "1311" "143.1" "5.73" "4.43" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf10409" "2580" "ENSG00000178950" "GAK" "hsa:2580; O14976; Q5U4P5; Q9BVY6" "" "Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis" "2" "0" "0.903" "1.051" "1.148" "1.346" "1.029" "1.342" "0.967" "1.323" "2.967" "37.1" "33.5" "39.0" "42.6" "50.0" "38.2" "49.8" "35.9" "49.1" "110.1" "" "" "" "" "" "" "" "" "" "" "19.7" "18.6" "22.3" "19.6" "27.0" "21.2" "29.3" "19.6" "27.5" "110.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7100137965290358990" "False" "High" "IsMasterProtein" "Q9UJW0" "Dynactin subunit 4 OS=Homo sapiens OX=9606 GN=DCTN4 PE=1 SV=1" "0.000" "False" "5.412" "3" "1" "1" "1" "460" "52.3" "7.34" "3.24" "1" "" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf05502" "51164" "ENSG00000132912" "DCTN4" "B3KWW0; D3DQH0; E5RGT5; hsa:51164; Q8TAN8; Q9UJW0" "Vasopressin-regulated water reabsorption" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; MHC class II antigen presentation; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9198167910452048535" "False" "High" "IsMasterProtein" "P18887" "DNA repair protein XRCC1 OS=Homo sapiens OX=9606 GN=XRCC1 PE=1 SV=3" "0.000" "False" "5.410" "3" "2" "2" "2" "633" "69.5" "6.28" "5.60" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00533, Pf01834" "7515" "ENSG00000073050" "XRCC1" "hsa:7515; P18887; Q6IBS4; Q9HCB1" "Base excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Gap-filling DNA repair synthesis and ligation in TC-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; HDR through MMEJ (alt-NHEJ); Resolution of AP sites via the single-nucleotide replacement pathway; Gap-filling DNA repair synthesis and ligation in GG-NER" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6036892115816411697" "False" "High" "IsMasterProtein" "Q9H9G7" "Protein argonaute-3 OS=Homo sapiens OX=9606 GN=AGO3 PE=1 SV=2" "0.000" "False" "5.404" "2" "2" "2" "1" "860" "97.3" "9.11" "5.43" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02170, Pf02171, Pf08699, Pf16486, Pf16487, Pf16488" "192669" "ENSG00000126070" "AGO3" "B1ALI0; hsa:192669; Q5TA55; Q9H1U6; Q9H9G7" "" "Oxidative Stress Induced Senescence; MAPK6/MAPK4 signaling; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Ca2+ pathway; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Small interfering RNA (siRNA) biogenesis; Nuclear events stimulated by ALK signaling in cancer; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "21" "0" "1.065" "1.005" "1.347" "1.122" "1.071" "1.238" "1.258" "1.377" "0.982" "188.2" "200.6" "189.2" "253.5" "211.2" "201.7" "233.0" "236.8" "259.3" "184.8" "" "" "" "" "" "" "" "" "" "" "99.7" "111.2" "108.3" "116.8" "114.3" "112.2" "137.1" "129.2" "145.4" "184.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5985118232380264359" "False" "High" "IsMasterProtein" "Q15363" "Transmembrane emp24 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=TMED2 PE=1 SV=1" "0.000" "False" "5.404" "9" "2" "2" "2" "201" "22.7" "5.17" "2.46" "2" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi;other cell component" "signal transduction activity or receptor binding" "Pf01105" "10959" "ENSG00000086598" "TMED2" "hsa:10959; Q15363" "5q35 copy number variation" "COPII-mediated vesicle transport; Cargo concentration in the ER; COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; Pre-NOTCH Processing in Golgi" "6" "0" "1.097" "0.970" "1.026" "0.970" "1.215" "1.176" "0.977" "1.083" "1.604" "61.2" "67.1" "59.4" "62.8" "59.4" "74.4" "72.0" "59.8" "66.3" "98.2" "" "" "" "" "" "" "" "" "" "" "32.4" "37.2" "34.0" "28.9" "32.1" "41.4" "42.4" "32.6" "37.2" "98.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9069432479560653681" "False" "High" "IsMasterProtein" "Q08AM6" "Protein VAC14 homolog OS=Homo sapiens OX=9606 GN=VAC14 PE=1 SV=1" "0.000" "False" "5.399" "2" "2" "2" "2" "782" "87.9" "6.13" "6.20" "2" "other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf11916, Pf12755" "55697" "ENSG00000103043" "VAC14" "B3KPJ5; B3KSM8; hsa:55697; Q08AM6; Q13174; Q6IA12; Q7L4Y1; Q9BW96; Q9H6V6" "" "Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "3" "0" "0.943" "0.953" "0.948" "0.975" "0.982" "0.906" "0.856" "0.861" "0.606" "320.5" "302.1" "305.4" "303.8" "312.6" "314.8" "290.4" "274.5" "275.9" "194.3" "" "" "" "" "" "" "" "" "" "" "169.7" "167.5" "174.9" "139.9" "169.1" "175.1" "170.9" "149.8" "154.8" "194.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "289518910119416826" "False" "High" "IsMasterProtein" "P61966" "AP-1 complex subunit sigma-1A OS=Homo sapiens OX=9606 GN=AP1S1 PE=1 SV=1" "0.000" "False" "5.382" "10" "1" "1" "1" "158" "18.7" "5.73" "4.14" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01217" "1174" "ENSG00000106367" "AP1S1" "B2R5D8; hsa:1174; P61966; P82267; Q00382; Q53YA7; Q9BTN4; Q9UDW9" "" "Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; MHC class II antigen presentation; Nef mediated downregulation of MHC class I complex cell surface expression" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6104701307196402264" "False" "High" "IsMasterProtein" "Q96PE3" "Inositol polyphosphate-4-phosphatase type I A OS=Homo sapiens OX=9606 GN=INPP4A PE=1 SV=1" "0.000" "False" "5.381" "1" "1" "2" "1" "977" "109.9" "6.96" "7.11" "1" "other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "" "3631" "ENSG00000040933" "INPP4A" "hsa:3631; O15326; Q13187; Q53TD8; Q8TC02; Q96PE3" "Insulin signaling" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of IP2, IP, and Ins in the cytosol" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8423697794257816374" "False" "High" "IsMasterProtein" "Q6ZMU5" "Tripartite motif-containing protein 72 OS=Homo sapiens OX=9606 GN=TRIM72 PE=1 SV=2" "0.000" "False" "5.375" "4" "2" "2" "2" "477" "52.7" "6.48" "2.74" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13765, Pf15227" "493829" "ENSG00000177238" "TRIM72" "hsa:493829; Q6ZMU5; Q8N4X6; Q8NBD9" "" "Smooth Muscle Contraction" "1" "0" "0.886" "1.057" "1.193" "1.030" "1.159" "1.061" "1.052" "1.032" "0.899" "130.0" "115.2" "137.4" "155.2" "133.9" "150.8" "137.9" "136.8" "134.3" "117.0" "" "" "" "" "" "" "" "" "" "" "68.9" "63.9" "78.7" "71.5" "72.5" "83.9" "81.2" "74.7" "75.3" "117.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7723203762439641288" "False" "High" "IsMasterProtein" "Q9Y5N5" "Methyltransferase N6AMT1 OS=Homo sapiens OX=9606 GN=N6AMT1 PE=1 SV=4" "0.000" "False" "5.369" "9" "2" "2" "2" "214" "22.9" "5.11" "5.32" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05175" "29104" "ENSG00000156239" "N6AMT1" "B2RA97; hsa:29104; Q96F73; Q9Y5N5" "" "Eukaryotic Translation Termination; Methylation" "2" "0" "0.914" "0.946" "0.874" "0.946" "0.995" "0.963" "0.923" "0.908" "0.501" "497.5" "454.8" "470.8" "434.7" "470.6" "494.8" "479.0" "459.2" "451.7" "249.0" "" "" "" "" "" "" "" "" "" "" "263.4" "252.2" "269.6" "200.2" "254.6" "275.2" "281.9" "250.7" "253.4" "249.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8425906233400524175" "False" "High" "IsMasterProtein" "P17026" "Zinc finger protein 22 OS=Homo sapiens OX=9606 GN=ZNF22 PE=1 SV=3" "0.000" "False" "5.366" "8" "2" "2" "2" "224" "25.9" "10.04" "5.33" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "7570" "ENSG00000165512" "ZNF22" "hsa:7570; P17026; Q5T741; Q96FM4" "" "" "0" "0" "1.109" "1.034" "0.933" "0.987" "1.153" "1.111" "0.960" "1.247" "0.937" "49.8" "55.2" "51.4" "46.4" "49.1" "57.4" "55.3" "47.8" "62.1" "46.7" "" "" "" "" "" "" "" "" "" "" "26.4" "30.6" "29.5" "21.4" "26.6" "31.9" "32.6" "26.1" "34.8" "46.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4068487784358334043" "False" "High" "IsMasterProtein" "Q8TDX7" "Serine/threonine-protein kinase Nek7 OS=Homo sapiens OX=9606 GN=NEK7 PE=1 SV=1" "0.000" "False" "5.362" "4" "1" "1" "1" "302" "34.5" "8.25" "4.08" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "140609" "ENSG00000151414" "NEK7" "A6NGT8; hsa:140609; Q8TDX7" "Ciliary landscape; EPAC1 and PKA reduction of retinal inflammation" "Nuclear Pore Complex (NPC) Disassembly; EML4 and NUDC in mitotic spindle formation; Activation of NIMA Kinases NEK9, NEK6, NEK7" "5" "0" "0.902" "0.965" "0.853" "1.077" "1.062" "0.922" "0.747" "1.091" "1.338" "85.9" "77.5" "82.9" "73.2" "92.5" "91.2" "79.2" "64.1" "93.7" "114.9" "" "" "" "" "" "" "" "" "" "" "45.5" "43.0" "47.5" "33.7" "50.1" "50.7" "46.6" "35.0" "52.6" "114.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-378984088295691653" "False" "High" "IsMasterProtein" "P49023" "Paxillin OS=Homo sapiens OX=9606 GN=PXN PE=1 SV=3" "0.000" "False" "5.361" "3" "2" "2" "2" "591" "64.5" "6.19" "5.76" "2" "cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00412, Pf03535" "5829" "ENSG00000089159" "PXN" "B2RAI3; B7ZMB4; hsa:5829; O14970; O14971; O60360; P49023; Q5HYA4" "Integrin-mediated cell adhesion; Prolactin signaling pathway; Androgen receptor network in prostate cancer; Oncostatin M signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; 3q29 copy number variation syndrome; Regulation of actin cytoskeleton; GDNF signaling; HDAC6 interactions in the central nervous system" "VEGFA-VEGFR2 Pathway; GAB1 signalosome; Smooth Muscle Contraction; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Localization of the PINCH-ILK-PARVIN complex to focal adhesions; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "21" "0" "1.132" "1.174" "0.929" "1.155" "1.108" "0.922" "1.134" "1.326" "0.843" "163.2" "184.7" "191.5" "151.5" "188.5" "180.8" "150.4" "185.0" "216.3" "137.6" "" "" "" "" "" "" "" "" "" "" "86.4" "102.4" "109.7" "69.8" "102.0" "100.6" "88.5" "101.0" "121.3" "137.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2951655110054191757" "False" "High" "IsMasterProtein" "Q5VW32" "BRO1 domain-containing protein BROX OS=Homo sapiens OX=9606 GN=BROX PE=1 SV=1" "0.000" "False" "5.361" "6" "3" "3" "3" "411" "46.4" "7.65" "6.86" "3" "cell cycle OR cell proliferation;cell organization and biogenesis" "other membranes;nucleus" "" "Pf03097" "148362" "ENSG00000162819" "BROX" "B7Z9G5; hsa:148362; Q5VW32; Q96MG1" "" "" "0" "0" "1.020" "0.844" "1.108" "0.899" "1.035" "1.131" "0.579" "0.915" "4.671" "65.1" "66.4" "54.9" "72.1" "58.5" "67.4" "73.6" "37.7" "59.6" "304.1" "" "" "" "" "" "" "" "" "" "" "34.5" "36.8" "31.5" "33.2" "31.7" "37.5" "43.3" "20.6" "33.4" "304.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5839197527488627088" "False" "High" "IsMasterProtein" "P09110" "3-ketoacyl-CoA thiolase, peroxisomal OS=Homo sapiens OX=9606 GN=ACAA1 PE=1 SV=2" "0.000" "False" "5.361" "7" "2" "2" "2" "424" "44.3" "8.44" "5.80" "2" "other metabolic processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00108, Pf02803" "30" "ENSG00000060971" "ACAA1" "G5E935; hsa:30; P09110; Q96CA6" "PPAR-alpha pathway; Nuclear receptors meta-pathway; Amino acid metabolism; PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX)" "Neutrophil degranulation; TYSND1 cleaves peroxisomal proteins; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of very long chain fatty acids" "11" "0" "1.035" "1.073" "1.037" "0.987" "1.101" "0.873" "1.050" "0.859" "0.573" "223.0" "230.8" "239.3" "231.2" "220.0" "245.4" "194.7" "234.2" "191.4" "127.8" "" "" "" "" "" "" "" "" "" "" "118.1" "128.0" "137.0" "106.5" "119.0" "136.5" "114.6" "127.8" "107.4" "127.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5858537743821975597" "False" "High" "IsMasterProtein" "O75843" "AP-1 complex subunit gamma-like 2 OS=Homo sapiens OX=9606 GN=AP1G2 PE=1 SV=1" "0.000" "False" "5.359" "3" "3" "3" "2" "785" "87.1" "6.55" "6.59" "3" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf01602, Pf02883" "8906" "ENSG00000213983" "AP1G2" "D3DS51; hsa:8906; O75504; O75843" "" "Lysosome Vesicle Biogenesis" "1" "0" "1.066" "1.223" "1.308" "0.925" "0.937" "0.973" "1.323" "1.053" "1.089" "141.7" "151.0" "173.3" "185.3" "131.1" "132.8" "137.9" "187.4" "149.2" "154.3" "" "" "" "" "" "" "" "" "" "" "75.0" "83.7" "99.2" "85.3" "70.9" "73.8" "81.1" "102.3" "83.7" "154.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5151232376153751801" "False" "High" "IsMasterProtein" "Q9UIM3" "FK506-binding protein-like OS=Homo sapiens OX=9606 GN=FKBPL PE=1 SV=1" "0.000" "False" "5.357" "5" "2" "2" "2" "349" "38.2" "5.50" "4.43" "2" "other biological processes" "non-structural extracellular;cytosol" "" "Pf00515" "63943" "ENSG00000204315; ENSG00000223666; ENSG00000224200; ENSG00000230907" "FKBPL" "A8K5V3; B0UYX8; hsa:63943; Q9H5G3; Q9UIM3" "" "The role of GTSE1 in G2/M progression after G2 checkpoint" "1" "0" "0.947" "0.879" "0.934" "0.970" "0.968" "0.895" "1.000" "1.095" "0.750" "116.2" "110.0" "102.1" "108.5" "112.7" "112.4" "104.0" "116.2" "127.2" "87.1" "" "" "" "" "" "" "" "" "" "" "61.5" "61.0" "58.5" "50.0" "61.0" "62.5" "61.2" "63.4" "71.4" "87.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3524460011519656721" "False" "High" "IsMasterProtein" "P50749" "Ras association domain-containing protein 2 OS=Homo sapiens OX=9606 GN=RASSF2 PE=1 SV=1" "0.000" "False" "5.355" "6" "2" "2" "2" "326" "37.8" "8.84" "4.55" "2" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity" "Pf00788, Pf16517" "9770" "ENSG00000101265" "RASSF2" "A6NIX9; A8K5Z3; hsa:9770; P50749; Q17S06; Q53HD0; Q6AHZ2; Q8IZA5" "Pleural mesothelioma" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3035595102958398127" "False" "High" "IsMasterProtein" "P46777" "Large ribosomal subunit protein uL18 OS=Homo sapiens OX=9606 GN=RPL5 PE=1 SV=3" "0.000" "False" "5.352" "6" "2" "3" "2" "297" "34.3" "9.72" "5.13" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf14204, Pf17144" "6125" "ENSG00000122406" "RPL5" "hsa:6125; P46777; Q32LZ3; Q53HH6; Q9H3F4" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "1.039" "1.043" "1.065" "1.012" "0.995" "1.031" "1.178" "1.031" "1.093" "185.2" "192.4" "193.2" "197.3" "187.5" "184.4" "190.9" "218.2" "191.0" "202.5" "" "" "" "" "" "" "" "" "" "" "98.1" "106.7" "110.6" "90.9" "101.4" "102.5" "112.4" "119.1" "107.1" "202.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6012550924560015135" "False" "High" "IsMasterProtein" "O43805" "Microtubule nucleation factor SSNA1 OS=Homo sapiens OX=9606 GN=SSNA1 PE=1 SV=2" "0.000" "False" "5.339" "18" "3" "4" "3" "119" "13.6" "5.38" "11.68" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "8636" "ENSG00000176101" "SSNA1" "hsa:8636; O43805; Q5VSG0; Q6FG70; Q9BVW8" "Ciliary landscape" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "8" "0" "0.898" "0.948" "1.012" "0.896" "0.862" "0.867" "0.936" "0.932" "0.675" "1305.3" "1171.7" "1236.8" "1321.5" "1169.5" "1125.1" "1131.3" "1221.4" "1217.0" "881.1" "" "" "" "" "" "" "" "" "" "" "691.2" "649.6" "708.3" "608.6" "632.7" "625.8" "665.8" "666.7" "682.7" "881.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8595092831186639682" "False" "High" "IsMasterProtein" "Q99961" "Endophilin-A2 OS=Homo sapiens OX=9606 GN=SH3GL1 PE=1 SV=1" "0.000" "False" "5.333" "4" "2" "3" "2" "368" "41.5" "5.43" "7.96" "2" "cell organization and biogenesis;transport;developmental processes;signal transduction" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf03114" "6455" "ENSG00000141985" "SH3GL1" "B4DRA1; E7EVZ4; hsa:6455; M0QZV5; Q99668; Q99961" "Fragile X syndrome" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "6" "0" "1.066" "0.993" "1.085" "1.065" "1.173" "1.119" "0.642" "1.218" "5.180" "102.7" "109.6" "102.1" "111.4" "109.4" "120.5" "115.0" "65.9" "125.2" "532.3" "" "" "" "" "" "" "" "" "" "" "54.4" "60.8" "58.5" "51.3" "59.2" "67.0" "67.7" "36.0" "70.2" "532.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8582316469479536789" "False" "High" "IsMasterProtein" "Q92567" "Protein FAM168A OS=Homo sapiens OX=9606 GN=FAM168A PE=1 SV=2" "0.000" "False" "5.333" "4" "1" "1" "1" "244" "26.2" "8.98" "4.03" "1" "other biological processes" "" "" "Pf14944" "23201" "ENSG00000054965" "FAM168A" "A2ICY2; A2ID81; hsa:23201; Q86UG2; Q92567" "" "" "0" "0" "0.919" "0.982" "1.110" "1.006" "0.989" "0.962" "1.117" "1.035" "0.564" "185.4" "170.3" "182.1" "205.8" "186.5" "183.4" "178.4" "207.1" "191.8" "104.5" "" "" "" "" "" "" "" "" "" "" "98.2" "94.4" "104.3" "94.8" "100.9" "102.0" "105.0" "113.0" "107.6" "104.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5339836283997496681" "False" "High" "IsMasterProtein" "O95163" "Elongator complex protein 1 OS=Homo sapiens OX=9606 GN=ELP1 PE=1 SV=3" "0.000" "False" "5.322" "1" "2" "2" "2" "1332" "150.2" "5.94" "4.77" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04762" "8518" "ENSG00000070061" "ELP1" "hsa:8518; O95163; Q5JSV2; Q9H327; Q9UG87" "HDAC6 interactions in the central nervous system" "HATs acetylate histones" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4099103662110185134" "False" "High" "IsMasterProtein" "Q08722" "Leukocyte surface antigen CD47 OS=Homo sapiens OX=9606 GN=CD47 PE=1 SV=1" "0.000" "False" "5.322" "6" "2" "2" "2" "323" "35.2" "7.21" "5.49" "2" "cell adhesion;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf04549, Pf08204" "961" "ENSG00000196776" "CD47" "A8K198; D3DN59; hsa:961; Q08722; Q53Y71; Q96A60" "Spinal cord injury; Pleural mesothelioma" "Neutrophil degranulation; Cell surface interactions at the vascular wall; Integrin cell surface interactions; Signal regulatory protein family interactions" "6" "0" "1.071" "1.080" "1.093" "0.916" "1.130" "1.079" "1.066" "0.978" "0.462" "210.1" "224.9" "226.8" "229.6" "192.5" "237.5" "226.7" "224.0" "205.4" "97.1" "" "" "" "" "" "" "" "" "" "" "111.3" "124.7" "129.9" "105.8" "104.2" "132.1" "133.4" "122.3" "115.2" "97.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-93736052394886069" "False" "High" "IsMasterProtein" "P50583" "Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] OS=Homo sapiens OX=9606 GN=NUDT2 PE=1 SV=3" "0.000" "False" "5.316" "10" "1" "1" "1" "147" "16.8" "5.35" "3.43" "1" "other metabolic processes;stress response;other biological processes" "mitochondrion" "other molecular function" "Pf00293" "318" "ENSG00000164978" "NUDT2" "D3DRM0; hsa:318; P50583; Q5T589" "" "Detoxification of Reactive Oxygen Species" "1" "0" "0.974" "1.263" "0.732" "0.926" "0.839" "0.859" "0.801" "0.860" "0.736" "122.6" "119.4" "154.9" "89.8" "113.6" "102.9" "105.3" "98.2" "105.4" "90.3" "" "" "" "" "" "" "" "" "" "" "64.9" "66.2" "88.7" "41.3" "61.4" "57.2" "62.0" "53.6" "59.2" "90.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4353457585173966729" "False" "High" "IsMasterProtein" "P84101" "Small EDRK-rich factor 2 OS=Homo sapiens OX=9606 GN=SERF2 PE=1 SV=1" "0.000" "False" "5.312" "29" "2" "2" "2" "59" "6.9" "10.45" "5.36" "2" "other biological processes" "cytosol;nucleus" "" "Pf04419" "10169" "ENSG00000140264" "SERF2" "A6NL45; B5MCG1; B9A026; hsa:10169; O75918; O88891; P84101; Q9BZH7" "" "" "0" "0" "0.860" "0.827" "0.804" "0.780" "0.795" "0.685" "0.709" "1.016" "0.336" "218.9" "188.2" "181.0" "176.0" "170.8" "174.0" "149.8" "155.1" "222.4" "73.5" "" "" "" "" "" "" "" "" "" "" "115.9" "104.4" "103.6" "81.0" "92.4" "96.8" "88.2" "84.7" "124.8" "73.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1252831994268086785" "False" "High" "IsMasterProtein" "O00268" "Transcription initiation factor TFIID subunit 4 OS=Homo sapiens OX=9606 GN=TAF4 PE=1 SV=2" "0.000" "False" "5.312" "2" "2" "2" "2" "1085" "110.0" "9.94" "2.66" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf05236, Pf07531" "6874" "ENSG00000130699" "TAF4" "A6NGD9; hsa:6874; O00268; Q5TBP6; Q99721; Q9BR40; Q9BX42" "" "RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8625580668015925346" "False" "High" "IsMasterProtein" "Q9HCK8" "Chromodomain-helicase-DNA-binding protein 8 OS=Homo sapiens OX=9606 GN=CHD8 PE=1 SV=5" "0.000" "False" "5.308" "1" "3" "3" "3" "2581" "290.3" "6.47" "2.51" "3" "cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf07533" "57680" "ENSG00000100888" "CHD8" "hsa:57680; Q4G0D8; Q68DQ0; Q6DKH9; Q6P440; Q6ZNL7; Q8N3Z9; Q8NCY4; Q8TBR9; Q96F26; Q9HCK8" "lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma" "Deactivation of the beta-catenin transactivating complex" "5" "0" "1.013" "0.970" "1.007" "1.075" "1.084" "1.023" "0.951" "0.944" "0.999" "297.8" "301.7" "289.0" "300.0" "320.0" "322.7" "304.6" "283.2" "281.1" "297.5" "" "" "" "" "" "" "" "" "" "" "157.7" "167.3" "165.5" "138.2" "173.1" "179.5" "179.3" "154.6" "157.7" "297.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4637087941136759499" "False" "High" "IsMasterProtein" "O15126" "Secretory carrier-associated membrane protein 1 OS=Homo sapiens OX=9606 GN=SCAMP1 PE=1 SV=2" "0.000" "False" "5.307" "5" "2" "2" "1" "338" "37.9" "7.42" "7.04" "2" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04144" "9522" "ENSG00000085365" "SCAMP1" "hsa:9522; O15126; O43587; Q6FG23; Q96BX1; Q96QK5" "" "Neutrophil degranulation" "1" "0" "0.891" "0.927" "0.901" "0.969" "0.873" "0.888" "0.912" "0.880" "0.517" "299.6" "266.9" "277.7" "269.9" "290.2" "261.4" "266.1" "273.1" "263.8" "154.9" "" "" "" "" "" "" "" "" "" "" "158.6" "148.0" "159.0" "124.3" "157.0" "145.4" "156.6" "149.1" "148.0" "154.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1229807806236447203" "False" "High" "IsMasterProtein" "Q7Z7L1" "Schlafen family member 11 OS=Homo sapiens OX=9606 GN=SLFN11 PE=1 SV=2" "0.000" "False" "5.300" "2" "2" "2" "1" "901" "102.8" "7.77" "4.96" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04326, Pf09848, Pf17057, Pf21026" "91607" "ENSG00000172716" "SLFN11" "E1P643; hsa:91607; Q7Z7L1; Q8N3S8; Q8N762; Q8TEE0" "17q12 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3096317975956610268" "False" "High" "IsMasterProtein" "Q9HBL8" "NmrA-like family domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NMRAL1 PE=1 SV=1" "0.000" "False" "5.298" "5" "2" "2" "2" "299" "33.3" "7.52" "5.08" "2" "" "cytosol;nucleus;other cell component" "other molecular function" "Pf05368" "57407" "ENSG00000153406; ENSG00000274684" "NMRAL1" "hsa:57407; Q9HBL8" "" "Urea cycle" "1" "0" "1.117" "1.206" "1.137" "1.278" "1.225" "1.268" "0.990" "1.086" "3.046" "109.0" "121.7" "131.5" "123.9" "139.3" "133.4" "138.1" "107.9" "118.3" "331.9" "" "" "" "" "" "" "" "" "" "" "57.7" "67.5" "75.3" "57.0" "75.4" "74.2" "81.3" "58.9" "66.4" "331.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6666030451106529783" "False" "High" "IsMasterProtein" "Q9NRY2" "SOSS complex subunit C OS=Homo sapiens OX=9606 GN=INIP PE=1 SV=1" "0.000" "False" "5.287" "13" "1" "2" "1" "104" "11.4" "9.25" "5.91" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf15925" "58493" "ENSG00000148153" "INIP" "hsa:58493; Q5VWJ7; Q96E04; Q9NRY2; Q9P090" "" "" "0" "0" "0.777" "0.872" "0.809" "0.827" "0.989" "0.890" "1.010" "1.028" "1.010" "111.2" "86.4" "97.0" "90.0" "92.0" "109.9" "99.0" "112.3" "114.3" "112.4" "" "" "" "" "" "" "" "" "" "" "58.9" "47.9" "55.5" "41.4" "49.8" "61.2" "58.2" "61.3" "64.1" "112.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6571071577836756123" "False" "High" "IsMasterProtein" "Q9NUP1" "Biogenesis of lysosome-related organelles complex 1 subunit 4 OS=Homo sapiens OX=9606 GN=BLOC1S4 PE=1 SV=1" "0.000" "False" "5.286" "8" "1" "1" "1" "217" "23.3" "4.98" "4.43" "1" "cell adhesion;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "cytosol;other cell component" "" "" "55330" "ENSG00000186222" "BLOC1S4" "hsa:55330; Q6NVY6; Q96G84; Q9NUP1" "Alstrom syndrome" "Golgi Associated Vesicle Biogenesis" "2" "0" "1.001" "1.022" "0.815" "1.117" "1.012" "0.992" "1.185" "1.083" "1.058" "64.8" "64.9" "66.3" "52.8" "72.4" "65.6" "64.3" "76.8" "70.2" "68.5" "" "" "" "" "" "" "" "" "" "" "34.3" "36.0" "37.9" "24.3" "39.2" "36.5" "37.9" "41.9" "39.4" "68.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1532626323839813541" "False" "High" "IsMasterProtein" "Q99622" "Protein C10 OS=Homo sapiens OX=9606 GN=C12orf57 PE=1 SV=1" "0.000" "False" "5.286" "12" "1" "1" "1" "126" "13.2" "5.14" "3.00" "1" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf14974" "113246" "ENSG00000111678" "C12orf57" "B2R4Q6; hsa:113246; Q99622" "" "" "0" "0" "0.988" "0.996" "1.118" "0.687" "0.852" "1.076" "0.949" "0.759" "1.595" "40.9" "40.4" "40.8" "45.8" "28.1" "34.9" "44.1" "38.9" "31.1" "65.3" "" "" "" "" "" "" "" "" "" "" "21.7" "22.4" "23.3" "21.1" "15.2" "19.4" "25.9" "21.2" "17.4" "65.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2337830748365545884" "False" "High" "IsMasterProtein" "Q53FT3" "Protein Hikeshi OS=Homo sapiens OX=9606 GN=HIKESHI PE=1 SV=2" "0.000" "False" "5.280" "8" "1" "1" "1" "197" "21.6" "5.45" "3.35" "1" "cell organization and biogenesis;stress response;transport;developmental processes" "cytosol;nucleus" "other molecular function" "Pf05603, Pf21057" "51501" "ENSG00000149196" "HIKESHI" "hsa:51501; Q53FT3; Q8WVE8; Q9NVQ2; Q9NZZ1; Q9P022; Q9P0N1" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "0.982" "1.057" "0.950" "0.939" "1.006" "0.904" "0.824" "0.880" "0.973" "103.4" "101.5" "109.2" "98.2" "97.0" "103.9" "93.5" "85.2" "91.0" "100.5" "" "" "" "" "" "" "" "" "" "" "54.7" "56.3" "62.6" "45.2" "52.5" "57.8" "55.0" "46.5" "51.0" "100.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "265917510829417511" "False" "High" "IsMasterProtein" "Q5JS37" "NHL repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=NHLRC3 PE=1 SV=1" "0.000" "False" "5.278" "4" "1" "1" "1" "347" "38.3" "6.43" "3.39" "1" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;other cytoplasmic organelle" "other molecular function" "Pf01436" "387921" "ENSG00000188811" "NHLRC3" "B2RTZ2; B4DTL0; hsa:387921; Q5JS37; Q69YI9" "" "Neutrophil degranulation" "1" "0" "1.024" "1.005" "1.422" "1.242" "1.069" "1.126" "1.017" "1.070" "1.052" "68.2" "69.9" "68.6" "97.0" "84.8" "73.0" "76.8" "69.4" "73.0" "71.8" "" "" "" "" "" "" "" "" "" "" "36.1" "38.8" "39.3" "44.7" "45.9" "40.6" "45.2" "37.9" "41.0" "71.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1871609499973025843" "False" "High" "IsMasterProtein" "Q07021" "Complement component 1 Q subcomponent-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=C1QBP PE=1 SV=1" "0.000" "False" "5.278" "7" "1" "1" "1" "282" "31.3" "4.84" "3.64" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;translation activity;nucleic acid binding activity;other molecular function" "Pf02330" "708" "ENSG00000108561" "C1QBP" "hsa:708; Q07021; Q2HXR8; Q9NNY8" "Complement system; Mesodermal commitment pathway; Ebola virus infection in host" "RHOC GTPase cycle; RHOA GTPase cycle; Intrinsic Pathway of Fibrin Clot Formation; Apoptotic factor-mediated response; Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function" "8" "0" "1.051" "1.154" "1.001" "0.970" "1.059" "1.005" "0.895" "0.927" "1.472" "23.7" "24.9" "27.3" "23.7" "23.0" "25.1" "23.8" "21.2" "22.0" "34.9" "" "" "" "" "" "" "" "" "" "" "12.5" "13.8" "15.7" "10.9" "12.4" "13.9" "14.0" "11.6" "12.3" "34.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3311968132693307525" "False" "High" "IsMasterProtein" "P42773" "Cyclin-dependent kinase 4 inhibitor C OS=Homo sapiens OX=9606 GN=CDKN2C PE=1 SV=1" "0.000" "False" "5.263" "9" "2" "2" "2" "168" "18.1" "6.52" "5.88" "2" "cell cycle OR cell proliferation;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf12796" "1031" "ENSG00000123080" "CDKN2C" "hsa:1031; P42773; Q8TB83" "Cell cycle; Glioblastoma signaling pathways; Vitamin D receptor pathway; G1 to S cell cycle control" "Oxidative Stress Induced Senescence; Oncogene Induced Senescence; Cyclin D associated events in G1; Senescence-Associated Secretory Phenotype (SASP)" "8" "0" "0.981" "1.021" "0.918" "0.920" "0.951" "0.943" "0.997" "0.971" "0.644" "767.4" "753.1" "783.5" "704.5" "706.4" "729.7" "723.6" "764.8" "744.8" "494.3" "" "" "" "" "" "" "" "" "" "" "406.3" "417.6" "448.7" "324.4" "382.2" "405.9" "425.9" "417.5" "417.8" "494.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7984281592385059565" "False" "High" "IsMasterProtein" "Q6ZU35" "Capping protein-inhibiting regulator of actin dynamics OS=Homo sapiens OX=9606 GN=CRACD PE=1 SV=3" "0.000" "False" "5.251" "1" "2" "2" "2" "1233" "136.7" "5.60" "5.03" "2" "cell organization and biogenesis;other biological processes" "cytosol" "" "Pf15262" "57482" "ENSG00000109265" "CRACD" "hsa:57482; Q6ZU35; Q9NTE2; Q9NTP8; Q9ULK9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6249152470973198342" "False" "High" "IsMasterProtein" "Q9NYZ3" "G2 and S phase-expressed protein 1 OS=Homo sapiens OX=9606 GN=GTSE1 PE=1 SV=4" "0.000" "False" "5.243" "3" "2" "2" "2" "739" "78.5" "9.23" "3.02" "2" "cell cycle OR cell proliferation;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity" "Pf15259" "51512" "ENSG00000075218" "GTSE1" "B0QYM3; hsa:51512; Q20WK2; Q53GX5; Q5R3I6; Q6DHX4; Q9BRE0; Q9NYZ3; Q9UGZ9; Q9Y557" "" "G2/M Checkpoints; The role of GTSE1 in G2/M progression after G2 checkpoint" "2" "0" "1.139" "0.882" "1.252" "0.963" "0.941" "1.229" "0.956" "0.991" "1.071" "215.8" "245.7" "190.4" "270.1" "207.8" "203.0" "265.2" "206.4" "213.8" "231.1" "" "" "" "" "" "" "" "" "" "" "114.2" "136.2" "109.0" "124.4" "112.4" "112.9" "156.1" "112.6" "119.9" "231.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4348390061636338319" "False" "High" "IsMasterProtein" "Q9HAW4" "Claspin OS=Homo sapiens OX=9606 GN=CLSPN PE=1 SV=3" "0.000" "False" "5.231" "1" "2" "3" "2" "1339" "151.0" "4.82" "7.91" "2" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "" "63967" "ENSG00000092853" "CLSPN" "A6NFL4; hsa:63967; Q1RMC6; Q2KHM3; Q5VYG0; Q6P6H5; Q8IWI1; Q9HAW4" "" "Activation of ATR in response to replication stress; Ub-specific processing proteases; Processing of DNA double-strand break ends; Apoptotic cleavage of cellular proteins" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2629792950046784631" "False" "High" "IsMasterProtein" "Q12849" "G-rich sequence factor 1 OS=Homo sapiens OX=9606 GN=GRSF1 PE=1 SV=3" "0.000" "False" "5.228" "2" "1" "1" "1" "480" "53.1" "6.19" "3.82" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "2926" "ENSG00000132463" "GRSF1" "B3KPW0; hsa:2926; Q12849; Q4W5S5; Q6ZST3; Q8IWD6; Q8NBD2" "VEGFA-VEGFR2 signaling" "Viral mRNA Translation; Mitochondrial RNA degradation" "3" "0" "0.911" "0.862" "0.880" "0.903" "1.012" "0.847" "0.404" "0.777" "7.186" "62.8" "57.2" "54.1" "55.2" "56.7" "63.6" "53.2" "25.4" "48.8" "451.3" "" "" "" "" "" "" "" "" "" "" "33.3" "31.7" "31.0" "25.4" "30.7" "35.4" "31.3" "13.8" "27.4" "451.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6888861531159930886" "False" "High" "IsMasterProtein" "Q9H832" "Ubiquitin-conjugating enzyme E2 Z OS=Homo sapiens OX=9606 GN=UBE2Z PE=1 SV=2" "0.000" "False" "5.227" "7" "3" "3" "3" "354" "38.2" "5.62" "7.73" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf00179" "65264" "ENSG00000159202" "UBE2Z" "A6N8M6; A6NC60; hsa:65264; Q7L354; Q8TCM4; Q9H832; Q9H893" "" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "1.028" "0.960" "1.079" "1.025" "1.042" "1.031" "1.009" "1.066" "0.746" "348.3" "358.0" "334.4" "375.7" "357.1" "363.0" "359.0" "351.3" "371.1" "259.9" "" "" "" "" "" "" "" "" "" "" "184.4" "198.5" "191.5" "173.0" "193.2" "201.9" "211.3" "191.8" "208.2" "259.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3661455698439909776" "False" "High" "IsMasterProtein" "Q96AG4" "Leucine-rich repeat-containing protein 59 OS=Homo sapiens OX=9606 GN=LRRC59 PE=1 SV=1" "0.000" "False" "5.222" "6" "2" "2" "2" "307" "34.9" "9.57" "5.44" "2" "signal transduction" "other membranes;mitochondrion;ER/Golgi;nucleus;other cell component" "" "Pf13855" "55379" "ENSG00000108829" "LRRC59" "B2RE83; D3DTX8; hsa:55379; Q96AG4; Q9P189" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.050" "1.206" "0.973" "1.047" "1.020" "0.879" "1.097" "1.045" "0.746" "199.9" "209.8" "241.1" "194.5" "209.4" "203.8" "175.6" "219.3" "208.9" "149.1" "" "" "" "" "" "" "" "" "" "" "105.8" "116.3" "138.1" "89.6" "113.3" "113.4" "103.3" "119.7" "117.2" "149.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5097662091813912850" "False" "High" "IsMasterProtein" "Q02252" "Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial OS=Homo sapiens OX=9606 GN=ALDH6A1 PE=1 SV=2" "0.000" "False" "5.216" "4" "2" "2" "2" "535" "57.8" "8.50" "5.08" "2" "other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf00171" "4329" "ENSG00000119711" "ALDH6A1" "B2R609; B4DFS8; hsa:4329; J3KNU8; Q02252; Q9UKM8" "" "Branched-chain amino acid catabolism" "1" "0" "0.882" "0.991" "1.010" "0.985" "1.025" "0.919" "0.744" "0.863" "3.373" "190.7" "168.3" "189.0" "192.6" "188.0" "195.6" "175.2" "142.0" "164.7" "643.4" "" "" "" "" "" "" "" "" "" "" "101.0" "93.3" "108.2" "88.7" "101.7" "108.8" "103.1" "77.5" "92.4" "643.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7441376780111574138" "False" "High" "IsMasterProtein" "Q96BS2" "Calcineurin B homologous protein 3 OS=Homo sapiens OX=9606 GN=TESC PE=1 SV=3" "0.000" "False" "5.210" "6" "1" "2" "1" "214" "24.7" "4.93" "5.68" "1" "protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf13405" "54997" "ENSG00000088992" "TESC" "F5H1Y5; hsa:54997; Q96BS2; Q9NWT9" "" "" "0" "0" "0.817" "0.948" "1.027" "1.048" "0.907" "1.019" "0.962" "1.046" "1.670" "105.4" "86.1" "99.8" "108.2" "110.4" "95.6" "107.4" "101.4" "110.2" "175.9" "" "" "" "" "" "" "" "" "" "" "55.8" "47.7" "57.2" "49.8" "59.7" "53.2" "63.2" "55.3" "61.8" "175.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8260610778738387308" "False" "High" "IsMasterProtein" "Q13907" "Isopentenyl-diphosphate Delta-isomerase 1 OS=Homo sapiens OX=9606 GN=IDI1 PE=1 SV=2" "0.000" "False" "5.204" "8" "2" "3" "2" "227" "26.3" "6.34" "10.33" "2" "other metabolic processes" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00293" "3422" "ENSG00000067064" "IDI1" "B4E155; hsa:3422; Q13907; Q32Q13; Q53GQ6; Q86U81; Q8WUX8; Q96IZ4; Q9BQ74" "Target of rapamycin signaling; Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Exercise-induced circadian regulation; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Cholesterol biosynthesis pathway in hepatocytes; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "11" "0" "0.977" "0.930" "0.842" "0.908" "0.923" "1.009" "0.843" "0.873" "0.666" "1226.6" "1198.2" "1140.5" "1033.3" "1113.4" "1131.7" "1238.2" "1034.3" "1070.9" "817.1" "" "" "" "" "" "" "" "" "" "" "649.5" "664.3" "653.2" "475.9" "602.4" "629.5" "728.7" "564.6" "600.7" "817.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3522483334195236405" "False" "High" "IsMasterProtein" "Q13542" "Eukaryotic translation initiation factor 4E-binding protein 2 OS=Homo sapiens OX=9606 GN=EIF4EBP2 PE=1 SV=1" "0.000" "False" "5.202" "12" "1" "2" "1" "120" "12.9" "6.67" "6.70" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05456" "1979" "ENSG00000148730" "EIF4EBP2" "hsa:1979; Q13542" "Translation factors; Fragile X syndrome" "" "2" "0" "0.960" "1.057" "1.265" "1.122" "1.090" "1.089" "0.920" "1.001" "0.829" "101.1" "97.1" "106.9" "127.9" "113.5" "110.2" "110.1" "93.0" "101.2" "83.9" "" "" "" "" "" "" "" "" "" "" "53.6" "53.9" "61.2" "58.9" "61.4" "61.3" "64.8" "50.8" "56.8" "83.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-345660777743534482" "False" "High" "IsMasterProtein" "Q9NPJ6" "Mediator of RNA polymerase II transcription subunit 4 OS=Homo sapiens OX=9606 GN=MED4 PE=1 SV=1" "0.000" "False" "5.199" "4" "1" "1" "1" "270" "29.7" "5.10" "3.53" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf10018" "29079" "ENSG00000136146" "MED4" "B4DX67; hsa:29079; Q53GB4; Q53H68; Q5T912; Q6FHC4; Q6IA79; Q9BS95; Q9NPJ6; Q9NYR5" "" "Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; RSV-host interactions; Generic Transcription Pathway" "4" "0" "1.136" "1.068" "1.035" "1.124" "1.009" "1.189" "1.049" "1.226" "1.475" "162.8" "184.9" "173.8" "168.4" "183.0" "164.3" "193.5" "170.8" "199.5" "240.0" "" "" "" "" "" "" "" "" "" "" "86.2" "102.5" "99.6" "77.6" "99.0" "91.4" "113.9" "93.2" "111.9" "240.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4683582367495080514" "False" "High" "IsMasterProtein" "Q6IA86" "Elongator complex protein 2 OS=Homo sapiens OX=9606 GN=ELP2 PE=1 SV=2" "0.000" "False" "5.192" "2" "2" "2" "2" "826" "92.4" "5.96" "2.92" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "55250" "ENSG00000134759" "ELP2" "A8KAI6; B4DTG0; B4DXP0; E7EP23; E9PCX0; Q53GZ0; Q687Y8; Q6IA86; Q8N5C2; Q96GV4; Q96PI7; Q9H9N0; Q9NV81" "" "HATs acetylate histones" "1" "0" "1.207" "1.012" "0.969" "1.077" "1.309" "1.337" "1.024" "1.066" "1.806" "34.7" "41.9" "35.1" "33.6" "37.4" "45.4" "46.4" "35.6" "37.0" "62.7" "" "" "" "" "" "" "" "" "" "" "18.4" "23.2" "20.1" "15.5" "20.2" "25.3" "27.3" "19.4" "20.8" "62.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-580197304848334652" "False" "High" "IsMasterProtein" "Q13496" "Myotubularin OS=Homo sapiens OX=9606 GN=MTM1 PE=1 SV=2" "0.000" "False" "5.185" "3" "2" "2" "2" "603" "69.9" "8.18" "3.18" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02893, Pf06602" "4534" "ENSG00000171100" "MTM1" "A6NDB1; B7Z491; F2Z330; hsa:4534; Q13496; Q8NEL1" "" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1820553366353762966" "False" "High" "IsMasterProtein" "Q9UKF7" "Cytoplasmic phosphatidylinositol transfer protein 1 OS=Homo sapiens OX=9606 GN=PITPNC1 PE=1 SV=3" "0.000" "False" "5.184" "6" "2" "3" "2" "332" "38.4" "6.40" "7.53" "2" "cell organization and biogenesis;transport;signal transduction" "cytosol;nucleus;other cell component" "transporter activity;other molecular function" "Pf02121" "26207" "ENSG00000154217" "PITPNC1" "A8K473; hsa:26207; J3QR20; Q96I07; Q9UKF7" "" "" "0" "0" "1.275" "1.352" "1.321" "1.073" "1.131" "1.204" "1.057" "1.171" "1.081" "79.8" "101.8" "107.9" "105.4" "85.6" "90.2" "96.1" "84.4" "93.5" "86.3" "" "" "" "" "" "" "" "" "" "" "42.3" "56.4" "61.8" "48.5" "46.3" "50.2" "56.5" "46.1" "52.4" "86.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4664258247594329003" "False" "High" "IsMasterProtein" "Q9H9B1" "Histone-lysine N-methyltransferase EHMT1 OS=Homo sapiens OX=9606 GN=EHMT1 PE=1 SV=4" "0.000" "False" "5.178" "2" "2" "3" "2" "1298" "141.4" "5.76" "5.36" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00856, Pf05033, Pf12796, Pf21533" "79813" "ENSG00000181090" "EHMT1" "B1AQ58; B1AQ59; hsa:79813; Q86X08; Q8TCN7; Q96F53; Q96JF1; Q96KH4; Q9H9B1" "Histone modifications; MTHFR deficiency; Kleefstra syndrome" "Senescence-Associated Secretory Phenotype (SASP); Regulation of TP53 Activity through Methylation; Transcriptional Regulation by E2F6; Transcriptional Regulation by VENTX; PKMTs methylate histone lysines" "8" "0" "0.984" "1.074" "1.299" "1.025" "0.930" "1.607" "1.613" "1.619" "1.347" "68.3" "67.3" "73.4" "88.8" "70.1" "63.6" "109.8" "110.3" "110.6" "92.1" "" "" "" "" "" "" "" "" "" "" "36.2" "37.3" "42.0" "40.9" "37.9" "35.4" "64.6" "60.2" "62.1" "92.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7630345377865006626" "False" "High" "IsMasterProtein" "Q9NVS9" "Pyridoxine-5'-phosphate oxidase OS=Homo sapiens OX=9606 GN=PNPO PE=1 SV=1" "0.000" "False" "5.177" "6" "1" "3" "1" "261" "30.0" "7.06" "8.26" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf01243, Pf10590" "55163" "ENSG00000108439" "PNPO" "B4E0V0; B4E152; B4E1D7; D3DTT9; hsa:55163; Q9NVS9" "Selenium micronutrient network; Vitamin B6-dependent and responsive disorders" "Vitamin B6 activation to pyridoxal phosphate" "3" "0" "0.924" "1.030" "1.086" "1.024" "0.992" "1.091" "0.971" "0.990" "0.724" "192.3" "177.7" "198.0" "208.8" "196.8" "190.7" "209.8" "186.7" "190.4" "139.2" "" "" "" "" "" "" "" "" "" "" "101.8" "98.5" "113.4" "96.2" "106.5" "106.1" "123.5" "101.9" "106.8" "139.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5048841209035306562" "False" "High" "IsMasterProtein" "Q9H845" "Complex I assembly factor ACAD9, mitochondrial OS=Homo sapiens OX=9606 GN=ACAD9 PE=1 SV=1" "0.000" "False" "5.169" "3" "2" "2" "2" "621" "68.7" "7.96" "6.04" "2" "cell organization and biogenesis;other metabolic processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00441, Pf02770, Pf02771, Pf21343" "28976" "ENSG00000177646" "ACAD9" "D3DNB8; hsa:28976; Q8WXX3; Q9H845" "Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "Complex I biogenesis" "3" "0" "1.302" "1.154" "1.230" "1.192" "1.266" "1.075" "1.260" "1.052" "1.152" "96.9" "126.2" "111.9" "119.3" "115.5" "122.7" "104.2" "122.1" "102.0" "111.6" "" "" "" "" "" "" "" "" "" "" "51.3" "70.0" "64.1" "54.9" "62.5" "68.2" "61.3" "66.7" "57.2" "111.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7381193083052724868" "False" "High" "IsMasterProtein" "Q9Y6R4" "Mitogen-activated protein kinase kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP3K4 PE=1 SV=2" "0.000" "False" "5.168" "2" "3" "3" "3" "1608" "181.6" "6.32" "4.95" "3" "other metabolic processes;developmental processes;signal transduction;other biological processes" "other cell component" "kinase activity;other molecular function" "Pf00069, Pf19431" "4216" "ENSG00000085511" "MAP3K4" "A6H8W0; B7ZLD3; B9EG75; hsa:4216; Q5VTT8; Q5VTT9; Q92612; Q9H408; Q9Y6R4" "MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Insulin signaling; MAP3K1 role in promoting and blocking gonadal determination; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; G13 signaling pathway; DNA damage response (only ATM dependent)" "" "9" "0" "1.174" "1.057" "1.109" "1.108" "1.040" "0.956" "0.848" "0.935" "1.050" "331.9" "389.6" "350.9" "368.0" "367.8" "345.3" "317.3" "281.6" "310.2" "348.4" "" "" "" "" "" "" "" "" "" "" "175.8" "216.0" "201.0" "169.5" "199.0" "192.1" "186.7" "153.7" "174.0" "348.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6079513439335487390" "False" "High" "IsMasterProtein" "Q9UGV2" "Protein NDRG3 OS=Homo sapiens OX=9606 GN=NDRG3 PE=1 SV=2" "0.000" "False" "5.165" "4" "1" "1" "1" "375" "41.4" "5.31" "3.91" "1" "signal transduction;other biological processes" "other cell component" "" "Pf03096" "57446" "ENSG00000101079" "NDRG3" "A2A2S8; E1P5U7; E1P5U8; hsa:57446; Q5TH32; Q96PL8; Q96SM2; Q9BXY7; Q9H3N7; Q9H411; Q9H8J6; Q9UGV2" "" "" "0" "0" "1.014" "1.057" "0.980" "1.026" "1.161" "1.047" "1.117" "1.013" "1.262" "219.3" "222.5" "231.8" "214.9" "225.1" "254.7" "229.6" "244.9" "222.1" "276.8" "" "" "" "" "" "" "" "" "" "" "116.1" "123.4" "132.7" "99.0" "121.8" "141.7" "135.1" "133.7" "124.6" "276.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7634397569492690707" "False" "High" "IsMasterProtein" "Q96HY7" "2-oxoadipate dehydrogenase complex component E1 OS=Homo sapiens OX=9606 GN=DHTKD1 PE=1 SV=2" "0.000" "False" "5.162" "2" "2" "2" "2" "919" "103.0" "6.93" "6.09" "2" "other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf00676, Pf02779, Pf16870" "55526" "ENSG00000181192" "DHTKD1" "hsa:55526; Q68CU5; Q96HY7; Q9BUM8; Q9HCE2" "" "Glyoxylate metabolism and glycine degradation" "1" "0" "0.991" "0.923" "0.917" "0.931" "0.889" "0.873" "0.856" "0.835" "1.029" "270.4" "268.0" "249.6" "247.9" "251.7" "240.4" "236.1" "231.6" "225.8" "278.3" "" "" "" "" "" "" "" "" "" "" "143.2" "148.6" "142.9" "114.2" "136.2" "133.7" "139.0" "126.4" "126.6" "278.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4571084566871798353" "False" "High" "IsMasterProtein" "Q9Y2S6" "Translation machinery-associated protein 7 OS=Homo sapiens OX=9606 GN=TMA7 PE=1 SV=1" "0.000" "False" "5.150" "14" "1" "2" "1" "64" "7.1" "9.99" "7.86" "1" "" "" "" "Pf09072" "51372" "ENSG00000232112" "TMA7" "hsa:51372; Q9P052; Q9Y2S6" "" "" "0" "0" "0.929" "1.094" "0.930" "0.861" "0.812" "0.922" "0.926" "0.805" "0.403" "694.4" "645.2" "759.6" "645.9" "597.9" "563.9" "640.5" "642.8" "559.3" "280.0" "" "" "" "" "" "" "" "" "" "" "367.7" "357.7" "435.0" "297.4" "323.5" "313.7" "376.9" "350.9" "313.7" "280.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8826640121646055106" "False" "High" "IsMasterProtein" "P13473" "Lysosome-associated membrane glycoprotein 2 OS=Homo sapiens OX=9606 GN=LAMP2 PE=1 SV=2" "0.000" "False" "5.145" "2" "1" "1" "1" "410" "44.9" "5.63" "3.85" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01299, Pf21222" "3920" "ENSG00000005893" "LAMP2" "A8K4X5; D3DTF0; hsa:3920; P13473; Q16641; Q6Q3G8; Q96J30; Q99534; Q9UD93" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Clock-controlled autophagy in bone metabolism" "Neutrophil degranulation; Platelet degranulation ; Chaperone Mediated Autophagy" "5" "0" "0.857" "1.021" "0.926" "1.057" "0.860" "0.940" "1.114" "0.943" "0.372" "295.8" "253.6" "302.1" "273.8" "312.8" "254.3" "278.0" "329.5" "279.0" "110.2" "" "" "" "" "" "" "" "" "" "" "156.6" "140.6" "173.0" "126.1" "169.2" "141.5" "163.6" "179.8" "156.5" "110.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8979611846707191829" "False" "High" "IsMasterProtein" "O76080" "AN1-type zinc finger protein 5 OS=Homo sapiens OX=9606 GN=ZFAND5 PE=1 SV=1" "0.000" "False" "5.142" "4" "1" "2" "1" "213" "23.1" "8.51" "6.82" "1" "developmental processes;signal transduction;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf01428, Pf01754" "7763" "ENSG00000107372" "ZFAND5" "A8K484; hsa:7763; O76080" "" "" "0" "0" "0.919" "1.034" "0.975" "0.911" "0.865" "0.816" "0.799" "0.769" "0.421" "317.9" "292.2" "328.6" "309.9" "289.7" "274.9" "259.5" "254.1" "244.5" "133.7" "" "" "" "" "" "" "" "" "" "" "168.3" "162.0" "188.2" "142.7" "156.7" "152.9" "152.7" "138.7" "137.2" "133.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2471884395781023228" "False" "High" "IsMasterProtein" "Q9Y5X2" "Sorting nexin-8 OS=Homo sapiens OX=9606 GN=SNX8 PE=1 SV=1" "0.000" "False" "5.126" "5" "2" "2" "2" "465" "52.5" "7.39" "4.18" "2" "transport" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00787, Pf19566" "29886" "ENSG00000106266" "SNX8" "A4D207; hsa:29886; Q96I67; Q9Y5X2" "" "" "0" "0" "1.073" "1.039" "0.953" "0.986" "0.945" "0.965" "1.125" "1.076" "1.101" "44.1" "47.4" "45.9" "42.1" "43.5" "41.7" "42.6" "49.7" "47.5" "48.6" "" "" "" "" "" "" "" "" "" "" "23.4" "26.3" "26.3" "19.4" "23.6" "23.2" "25.1" "27.1" "26.7" "48.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5831318780158998432" "False" "High" "IsMasterProtein" "Q9H0C8" "Integrin-linked kinase-associated serine/threonine phosphatase 2C OS=Homo sapiens OX=9606 GN=ILKAP PE=1 SV=1" "0.000" "False" "5.123" "4" "2" "3" "2" "392" "42.9" "7.09" "7.42" "2" "" "other cell component" "other molecular function" "Pf00481" "80895" "ENSG00000132323" "ILKAP" "B3KM39; hsa:80895; Q9H0C8" "2q37 copy number variation syndrome" "" "1" "0" "1.331" "1.143" "0.890" "1.197" "1.526" "0.940" "0.314" "1.345" "11.776" "32.9" "43.8" "37.6" "29.3" "39.4" "50.2" "30.9" "10.3" "44.3" "387.6" "" "" "" "" "" "" "" "" "" "" "17.4" "24.3" "21.5" "13.5" "21.3" "27.9" "18.2" "5.6" "24.8" "387.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5526079506929447963" "False" "High" "IsMasterProtein" "O14617" "AP-3 complex subunit delta-1 OS=Homo sapiens OX=9606 GN=AP3D1 PE=1 SV=1" "0.000" "False" "5.111" "2" "2" "3" "2" "1153" "130.1" "8.48" "5.18" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01602, Pf06375" "8943" "ENSG00000065000" "AP3D1" "O00202; O14617; O75262; Q59HF5; Q96G11; Q9H3C6" "" "" "0" "0" "1.181" "1.092" "1.174" "1.131" "1.184" "1.019" "0.932" "1.042" "1.460" "112.0" "132.2" "122.2" "131.5" "126.6" "132.5" "114.1" "104.4" "116.7" "163.5" "" "" "" "" "" "" "" "" "" "" "59.3" "73.3" "70.0" "60.5" "68.5" "73.7" "67.2" "57.0" "65.5" "163.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "947873724462567429" "False" "High" "IsMasterProtein" "Q9UNQ2" "Dimethyladenosine transferase OS=Homo sapiens OX=9606 GN=DIMT1 PE=1 SV=1" "0.000" "False" "5.101" "8" "3" "3" "3" "313" "35.2" "9.99" "5.29" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00398" "27292" "ENSG00000086189" "DIMT1" "O76025; Q9BU77; Q9UES1; Q9UNQ2" "" "rRNA modification in the nucleus and cytosol" "1" "0" "0.897" "0.885" "1.053" "1.020" "1.061" "1.160" "1.046" "1.128" "0.905" "272.7" "244.6" "241.4" "287.1" "278.2" "289.3" "316.4" "285.3" "307.5" "246.7" "" "" "" "" "" "" "" "" "" "" "144.4" "135.6" "138.3" "132.2" "150.5" "160.9" "186.2" "155.7" "172.5" "246.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1914361862769815360" "False" "High" "IsMasterProtein" "O00507" "Ubiquitin carboxyl-terminal hydrolase 9Y OS=Homo sapiens OX=9606 GN=USP9Y PE=1 SV=2" "0.000" "False" "5.097" "1" "2" "2" "2" "2555" "290.9" "5.86" "4.95" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf12030" "8287" "ENSG00000114374" "USP9Y" "hsa:8287; O00507; O14601" "" "" "0" "0" "0.818" "0.805" "0.862" "0.967" "1.040" "1.026" "0.867" "0.783" "1.041" "73.1" "59.8" "58.8" "63.0" "70.7" "76.0" "75.0" "63.3" "57.2" "76.1" "" "" "" "" "" "" "" "" "" "" "38.7" "33.2" "33.7" "29.0" "38.3" "42.3" "44.1" "34.6" "32.1" "76.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6665492664209257681" "False" "High" "IsMasterProtein" "Q6P1Q9" "tRNA N(3)-methylcytidine methyltransferase METTL2B OS=Homo sapiens OX=9606 GN=METTL2B PE=1 SV=3" "0.000" "False" "5.089" "6" "2" "2" "2" "378" "43.4" "5.86" "4.45" "2" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "other molecular function" "Pf08242" "55798" "ENSG00000165055" "METTL2B" "B4DZ68; hsa:55798; Q0IJ54; Q3B7J1; Q6P1Q9" "" "" "0" "0" "1.028" "0.839" "0.929" "0.839" "0.978" "0.898" "0.586" "0.854" "2.838" "91.7" "94.3" "77.0" "85.2" "77.0" "89.7" "82.3" "53.8" "78.4" "260.3" "" "" "" "" "" "" "" "" "" "" "48.6" "52.3" "44.1" "39.2" "41.7" "49.9" "48.5" "29.3" "44.0" "260.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6548869844035824343" "False" "High" "IsMasterProtein" "Q9UKM9" "RNA-binding protein Raly OS=Homo sapiens OX=9606 GN=RALY PE=1 SV=1" "0.000" "False" "5.088" "3" "1" "1" "1" "306" "32.4" "9.17" "2.67" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00076" "22913" "ENSG00000125970" "RALY" "hsa:22913; Q14621; Q2M365; Q5QPL8; Q9BQX6; Q9UJE3; Q9UKM9" "" "" "0" "0" "1.111" "1.390" "1.027" "0.895" "1.136" "0.786" "0.305" "1.110" "7.645" "55.2" "61.3" "76.7" "56.7" "49.4" "62.7" "43.4" "16.9" "61.3" "421.9" "" "" "" "" "" "" "" "" "" "" "29.2" "34.0" "43.9" "26.1" "26.7" "34.9" "25.5" "9.2" "34.4" "421.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2810950685469585295" "False" "High" "IsMasterProtein" "Q2TBE0" "CWF19-like protein 2 OS=Homo sapiens OX=9606 GN=CWF19L2 PE=1 SV=4" "0.000" "False" "5.080" "2" "2" "2" "2" "894" "103.7" "8.65" "2.60" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf04676, Pf04677" "143884" "ENSG00000152404" "CWF19L2" "A4FU66; A4FU67; A4FU68; A8KAD6; hsa:143884; Q2TBE0; Q6PHW1; Q96MI1" "" "mRNA Splicing - Major Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5613056624096108144" "False" "High" "IsMasterProtein" "Q7Z7E8" "Ubiquitin-conjugating enzyme E2 Q1 OS=Homo sapiens OX=9606 GN=UBE2Q1 PE=1 SV=1" "0.000" "False" "5.074" "4" "2" "2" "2" "422" "46.1" "5.10" "5.14" "2" "cell-cell signaling;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "55585" "ENSG00000160714" "UBE2Q1" "B4DF92; hsa:55585; Q29SN7; Q3B841; Q5I0X2; Q6IS04; Q6P7P2; Q7Z7E8; Q96MV4; Q9BVX5; Q9UGL6" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.980" "0.908" "0.952" "0.976" "0.943" "1.083" "0.829" "1.064" "3.076" "289.1" "283.4" "262.5" "275.3" "282.2" "272.8" "313.0" "239.8" "307.7" "889.3" "" "" "" "" "" "" "" "" "" "" "153.1" "157.1" "150.3" "126.8" "152.7" "151.7" "184.2" "130.9" "172.6" "889.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7526425454586707099" "False" "High" "IsMasterProtein" "Q8TE02" "Elongator complex protein 5 OS=Homo sapiens OX=9606 GN=ELP5 PE=1 SV=3" "0.000" "False" "5.069" "5" "1" "1" "1" "300" "33.2" "4.98" "4.00" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf10483" "23587" "ENSG00000170291; ENSG00000288485" "ELP5" "A8K1M5; D3DTN9; Q659B6; Q7Z2T4; Q8TDR9; Q8TE02; Q9BUB2; Q9Y2Q4" "" "HATs acetylate histones" "1" "0" "0.950" "0.948" "1.093" "1.121" "1.023" "1.076" "1.044" "1.041" "0.889" "73.2" "69.6" "69.4" "80.0" "82.1" "75.0" "78.8" "76.5" "76.3" "65.1" "" "" "" "" "" "" "" "" "" "" "38.8" "38.6" "39.7" "36.9" "44.4" "41.7" "46.4" "41.7" "42.8" "65.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7855128710481582123" "False" "High" "IsMasterProtein" "P50238" "Cysteine-rich protein 1 OS=Homo sapiens OX=9606 GN=CRIP1 PE=1 SV=3" "0.000" "False" "5.061" "21" "2" "3" "2" "77" "8.5" "8.75" "8.14" "2" "stress response;developmental processes;signal transduction;other biological processes" "other cell component" "other molecular function" "Pf00412" "1396" "ENSG00000213145" "CRIP1" "H3BPI2; hsa:1396; P50238; Q13628; Q53XY7; Q96J34" "" "" "0" "0" "0.909" "1.063" "0.924" "0.944" "0.885" "0.900" "0.947" "0.879" "0.419" "924.9" "840.6" "982.7" "854.8" "872.9" "818.8" "832.5" "876.0" "812.6" "387.3" "" "" "" "" "" "" "" "" "" "" "489.8" "466.1" "562.8" "393.7" "472.3" "455.4" "489.9" "478.2" "455.9" "387.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4937271554403891889" "False" "High" "IsMasterProtein" "P16150" "Leukosialin OS=Homo sapiens OX=9606 GN=SPN PE=1 SV=1" "0.000" "False" "5.059" "10" "2" "2" "2" "400" "40.3" "5.10" "1.82" "2" "cell adhesion;cell cycle OR cell proliferation;stress response;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "" "6693" "ENSG00000197471" "SPN" "A8K9B1; hsa:6693; P16150" "16p11.2 proximal deletion syndrome" "Basigin interactions" "3" "0" "1.027" "1.097" "1.045" "1.110" "1.288" "0.987" "1.154" "1.106" "0.811" "40.9" "42.0" "44.9" "42.8" "45.5" "52.7" "40.4" "47.2" "45.3" "33.2" "" "" "" "" "" "" "" "" "" "" "21.7" "23.3" "25.7" "19.7" "24.6" "29.3" "23.8" "25.8" "25.4" "33.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-700049213662343528" "False" "High" "IsMasterProtein" "P06396" "Gelsolin OS=Homo sapiens OX=9606 GN=GSN PE=1 SV=1" "0.000" "True" "5.054" "3" "2" "2" "2" "782" "85.6" "6.28" "1.88" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00626" "2934" "ENSG00000148180" "GSN" "A2A418; A8MUD1; A8MYN7; B7Z373; B7Z5V1; F5H1A8; hsa:2934; P06396; Q5T0I2; Q8WVV7" "Ebola virus infection in host; Regulation of actin cytoskeleton" "Neutrophil degranulation; Amyloid fiber formation; Sensory processing of sound by outer hair cells of the cochlea; Caspase-mediated cleavage of cytoskeletal proteins" "6" "0" "0.970" "1.080" "0.986" "0.970" "0.906" "1.142" "0.965" "0.975" "0.756" "73.4" "71.2" "79.3" "72.4" "71.2" "66.5" "83.9" "70.9" "71.6" "55.5" "" "" "" "" "" "" "" "" "" "" "38.9" "39.5" "45.4" "33.4" "38.5" "37.0" "49.4" "38.7" "40.2" "55.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5589324606331654897" "False" "High" "IsMasterProtein" "Q6P161" "Large ribosomal subunit protein mL54 OS=Homo sapiens OX=9606 GN=MRPL54 PE=1 SV=1" "0.000" "False" "5.037" "7" "1" "2" "1" "138" "15.8" "9.60" "8.18" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf08561" "116541" "ENSG00000183617" "MRPL54" "hsa:116541; Q6P161" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.940" "1.019" "0.974" "0.891" "0.849" "0.897" "1.027" "0.956" "0.453" "661.8" "622.4" "674.7" "644.8" "589.8" "561.7" "593.8" "679.9" "632.5" "299.6" "" "" "" "" "" "" "" "" "" "" "350.4" "345.1" "386.4" "296.9" "319.1" "312.4" "349.5" "371.1" "354.8" "299.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8070677658803742602" "False" "High" "IsMasterProtein" "P20585" "DNA mismatch repair protein Msh3 OS=Homo sapiens OX=9606 GN=MSH3 PE=1 SV=4" "0.000" "False" "5.032" "1" "1" "1" "1" "1137" "127.3" "8.02" "3.59" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00488, Pf01624, Pf05188, Pf05192" "4437" "ENSG00000113318" "MSH3" "A1L480; A1L482; A6NMM6; hsa:4437; P20585; Q6PJT5; Q86UQ6; Q92867" "Chromosomal and microsatellite instability in colorectal cancer ; DNA repair pathways, full network" "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MSH3; Defective Mismatch Repair Associated With MSH2" "5" "0" "0.923" "0.862" "0.845" "0.911" "0.824" "0.788" "0.637" "0.816" "2.467" "71.1" "65.6" "61.3" "60.1" "64.8" "58.6" "56.0" "45.3" "58.0" "175.4" "" "" "" "" "" "" "" "" "" "" "37.6" "36.4" "35.1" "27.7" "35.0" "32.6" "32.9" "24.7" "32.5" "175.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7864399280568064191" "False" "High" "IsMasterProtein" "Q9BT23" "LIM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=LIMD2 PE=1 SV=1" "0.000" "False" "5.022" "13" "2" "2" "2" "127" "14.1" "9.03" "5.22" "2" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00412" "80774" "ENSG00000136490" "LIMD2" "D3DU16; hsa:80774; Q96S91; Q9BT23" "" "" "0" "0" "0.929" "0.979" "0.862" "0.844" "0.860" "0.845" "0.972" "0.963" "0.437" "667.0" "619.7" "652.7" "575.2" "562.8" "573.7" "563.8" "648.3" "642.5" "291.7" "" "" "" "" "" "" "" "" "" "" "353.2" "343.6" "373.8" "264.9" "304.5" "319.1" "331.8" "353.9" "360.4" "291.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7824788000835968644" "False" "High" "IsMasterProtein" "O15182" "Centrin-3 OS=Homo sapiens OX=9606 GN=CETN3 PE=1 SV=2" "0.000" "False" "5.019" "8" "2" "2" "1" "167" "19.5" "4.74" "5.37" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf13499" "1070" "ENSG00000153140" "CETN3" "hsa:1070; O15182; Q53YD2; Q9BS23" "Breast cancer pathway" "" "1" "0" "1.106" "1.022" "1.018" "1.015" "1.178" "0.919" "0.912" "0.810" "1.042" "101.5" "112.3" "103.8" "103.4" "103.1" "119.6" "93.3" "92.6" "82.3" "105.8" "" "" "" "" "" "" "" "" "" "" "53.8" "62.3" "59.4" "47.6" "55.8" "66.5" "54.9" "50.5" "46.1" "105.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2644989191906863874" "False" "High" "IsMasterProtein" "Q6ZSZ5" "Rho guanine nucleotide exchange factor 18 OS=Homo sapiens OX=9606 GN=ARHGEF18 PE=1 SV=4" "0.000" "False" "5.018" "1" "1" "1" "1" "1361" "151.5" "6.33" "2.66" "1" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00621, Pf17838" "23370" "ENSG00000104880" "ARHGEF18" "A8MV62; B5ME81; hsa:23370; I3L1I5; O60274; Q6DD92; Q6ZSZ5" "" "RHOA GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8298200234612729181" "False" "High" "IsMasterProtein" "P46527" "Cyclin-dependent kinase inhibitor 1B OS=Homo sapiens OX=9606 GN=CDKN1B PE=1 SV=1" "0.000" "False" "5.006" "13" "2" "2" "2" "198" "22.1" "7.02" "3.71" "2" "cell cycle OR cell proliferation;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf02234" "1027" "ENSG00000111276" "CDKN1B" "hsa:1027; P46527; Q16307; Q5U0H2; Q9BUS6" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Integrated cancer pathway; Thyroid stimulating hormone (TSH) signaling pathway; IL-7 signaling pathway; Glioblastoma signaling pathways; Oncostatin M signaling pathway; Spinal cord injury; Retinoblastoma gene in cancer; Primary focal segmental glomerulosclerosis (FSGS); Aryl hydrocarbon receptor pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; Nuclear receptors meta-pathway; Ovarian infertility; Imatinib and chronic myeloid leukemia; Physico-chemical features and toxicity-associated pathways; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miR-222 in exercise-induced cardiac growth; Oxidative damage response; miRNA regulation of prostate cancer signaling pathways; PI3K-Akt signaling pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Galanin receptor pathway; Modulators of TCR signaling and T cell activation; DYRK1A involvement regarding cell proliferation in brain development; TROP2 regulatory signaling; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)" "Senescence-Associated Secretory Phenotype (SASP); Constitutive Signaling by AKT1 E17K in Cancer; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; SCF(Skp2)-mediated degradation of p27/p21; DNA Damage/Telomere Stress Induced Senescence; p53-Dependent G1 DNA Damage Response; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); RHO GTPases activate CIT; FOXO-mediated transcription of cell cycle genes; AKT phosphorylates targets in the cytosol; FLT3 Signaling; PTK6 Regulates Cell Cycle" "52" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5277181117143708744" "False" "High" "IsMasterProtein" "P60866" "Small ribosomal subunit protein uS10 OS=Homo sapiens OX=9606 GN=RPS20 PE=1 SV=1" "0.000" "False" "5.005" "15" "2" "3" "2" "119" "13.4" "9.94" "8.27" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00338" "6224" "ENSG00000008988" "RPS20" "B2R4F4; B4DW28; hsa:6224; P17075; P60866; Q5M8S9" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.100" "1.120" "1.190" "1.202" "1.190" "1.352" "1.492" "1.321" "0.908" "232.6" "255.9" "260.5" "276.7" "279.6" "276.8" "314.6" "347.0" "307.3" "211.3" "" "" "" "" "" "" "" "" "" "" "123.2" "141.9" "149.2" "127.4" "151.2" "154.0" "185.1" "189.4" "172.4" "211.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5480517122965498200" "False" "High" "IsMasterProtein" "P15735" "Phosphorylase b kinase gamma catalytic chain, liver/testis isoform OS=Homo sapiens OX=9606 GN=PHKG2 PE=1 SV=1" "0.000" "False" "5.000" "6" "3" "4" "3" "406" "46.4" "6.38" "8.34" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069" "5261" "ENSG00000156873" "PHKG2" "A8K0C7; B4DEB7; E9PEU3; hsa:5261; P11800; P15735" "Ferroptosis; Glycogen synthesis and degradation; 1p36 copy number variation syndrome" "Glycogen breakdown (glycogenolysis)" "4" "0" "1.116" "0.926" "0.989" "1.062" "0.966" "0.847" "0.717" "0.811" "1.231" "496.0" "553.5" "459.5" "490.7" "526.7" "478.9" "420.0" "355.6" "402.4" "610.8" "" "" "" "" "" "" "" "" "" "" "262.6" "306.9" "263.2" "226.0" "285.0" "266.4" "247.2" "194.1" "225.8" "610.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2939496649029224586" "False" "High" "IsMasterProtein" "P51812" "Ribosomal protein S6 kinase alpha-3 OS=Homo sapiens OX=9606 GN=RPS6KA3 PE=1 SV=1" "0.000" "False" "4.991" "2" "2" "2" "1" "740" "83.7" "6.89" "5.49" "2" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00433" "6197" "ENSG00000177189" "RPS6KA3" "B2R9V4; hsa:6197; P51812; Q4VAP3; Q59H26; Q5JPK8; Q7Z3Z7" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Thermogenesis; EGF/EGFR signaling pathway; Cytoplasmic ribosomal proteins; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Macrophage-stimulating protein (MSP) signaling network map" "Senescence-Associated Secretory Phenotype (SASP); Recycling pathway of L1; RSK activation; ERK/MAPK targets; CREB phosphorylation; Gastrin-CREB signalling pathway via PKC and MAPK" "18" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1479259144489451223" "False" "High" "IsMasterProtein" "Q96DG6" "Carboxymethylenebutenolidase homolog OS=Homo sapiens OX=9606 GN=CMBL PE=1 SV=1" "0.000" "False" "4.988" "6" "2" "3" "2" "245" "28.0" "7.18" "8.32" "2" "other metabolic processes" "cytosol" "other molecular function" "Pf01738" "134147" "ENSG00000164237" "CMBL" "D3DTC7; hsa:134147; Q8TED6; Q96DG6" "" "Phase I - Functionalization of compounds" "1" "0" "0.872" "0.836" "0.816" "0.914" "0.916" "0.872" "0.907" "0.858" "0.567" "477.5" "416.5" "399.2" "389.8" "436.5" "437.3" "416.5" "433.2" "409.9" "270.9" "" "" "" "" "" "" "" "" "" "" "252.8" "230.9" "228.6" "179.5" "236.1" "243.3" "245.1" "236.5" "230.0" "270.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4865445723935678396" "False" "High" "IsMasterProtein" "Q13309" "S-phase kinase-associated protein 2 OS=Homo sapiens OX=9606 GN=SKP2 PE=1 SV=2" "0.000" "False" "4.973" "4" "2" "2" "2" "424" "47.7" "7.11" "5.15" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12937" "6502" "ENSG00000145604" "SKP2" "A8K5E0; B4DJT4; hsa:6502; Q13309; Q8TDZ0; Q8TDZ1; Q9BV69" "Cell cycle; Retinoblastoma gene in cancer; Imatinib and chronic myeloid leukemia" "Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Aberrant regulation of mitotic exit in cancer due to RB1 defects; Ub-specific processing proteases; Orc1 removal from chromatin; Regulation of RUNX2 expression and activity; Neddylation; SCF(Skp2)-mediated degradation of p27/p21; Cyclin D associated events in G1; Regulation of BACH1 activity" "13" "0" "0.916" "0.959" "0.983" "0.980" "0.946" "0.821" "0.771" "0.821" "1.734" "74.9" "68.6" "71.8" "73.6" "73.4" "70.8" "61.5" "57.7" "61.4" "129.8" "" "" "" "" "" "" "" "" "" "" "39.6" "38.0" "41.1" "33.9" "39.7" "39.4" "36.2" "31.5" "34.5" "129.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5260823146616738925" "False" "High" "IsMasterProtein" "O43829" "Zinc finger and BTB domain-containing protein 14 OS=Homo sapiens OX=9606 GN=ZBTB14 PE=1 SV=2" "0.000" "False" "4.967" "3" "2" "2" "2" "449" "50.9" "6.04" "3.63" "2" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "7541" "ENSG00000198081" "ZBTB14" "hsa:7541; O00403; O43829; Q2TB80" "" "" "0" "0" "1.003" "0.959" "1.039" "1.079" "1.034" "1.068" "1.066" "1.082" "0.989" "231.4" "232.0" "221.9" "240.3" "249.6" "239.3" "247.2" "246.7" "250.4" "228.8" "" "" "" "" "" "" "" "" "" "" "122.5" "128.6" "127.1" "110.7" "135.0" "133.1" "145.5" "134.7" "140.5" "228.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5023759696218809409" "False" "High" "IsMasterProtein" "Q7Z434" "Mitochondrial antiviral-signaling protein OS=Homo sapiens OX=9606 GN=MAVS PE=1 SV=2" "0.000" "False" "4.954" "2" "1" "1" "1" "540" "56.5" "5.52" "3.25" "1" "stress response;signal transduction;other biological processes" "other membranes;mitochondrion;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf16739" "57506" "ENSG00000088888" "MAVS" "A8K6X0; B2BD33; B2BD34; F5H6C8; hsa:57506; M1P2Z0; Q2HWT5; Q3I0Y2; Q5T7I6; Q7Z434; Q86VY7; Q9H1H3; Q9H4Y1; Q9H8D3; Q9ULE9" "Novel intracellular components of RIG-I-like receptor pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Lung pathology of COVID-19; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Negative regulators of DDX58/IFIH1 signaling; SARS-CoV-1 activates/modulates innate immune responses; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses; PKR-mediated signaling; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Ovarian tumor domain proteases" "24" "0" "0.951" "1.062" "1.064" "1.037" "1.007" "1.450" "1.486" "1.446" "0.745" "143.9" "136.8" "152.9" "153.1" "149.2" "144.8" "208.6" "213.8" "208.0" "107.2" "" "" "" "" "" "" "" "" "" "" "76.2" "75.9" "87.5" "70.5" "80.7" "80.6" "122.8" "116.7" "116.7" "107.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5430220103658382973" "False" "High" "IsMasterProtein" "Q969Q0" "Ribosomal protein eL42-like OS=Homo sapiens OX=9606 GN=RPL36AL PE=1 SV=3" "0.000" "False" "4.950" "16" "2" "3" "2" "106" "12.5" "10.65" "7.16" "2" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;ER/Golgi;translational apparatus;nucleus" "other molecular function" "Pf00935" "6166" "ENSG00000165502" "RPL36AL" "hsa:6166; Q3B7A5; Q969Q0" "" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "13" "0" "1.087" "1.015" "1.310" "1.182" "1.188" "1.356" "1.395" "1.383" "1.275" "300.0" "326.1" "304.4" "392.9" "354.7" "356.5" "407.0" "418.6" "414.9" "382.6" "" "" "" "" "" "" "" "" "" "" "158.9" "180.8" "174.3" "180.9" "191.9" "198.3" "239.5" "228.5" "232.8" "382.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7214504578644122811" "False" "High" "IsMasterProtein" "P62942" "Peptidyl-prolyl cis-trans isomerase FKBP1A OS=Homo sapiens OX=9606 GN=FKBP1A PE=1 SV=2" "0.000" "False" "4.939" "13" "1" "2" "1" "108" "11.9" "8.16" "6.28" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00254" "2280" "ENSG00000088832" "FKBP1A" "D3DVW6; hsa:2280; P20071; P62942; Q4VC47; Q6FGD9; Q6LEU3; Q9H103; Q9H566" "Target of rapamycin signaling; Spinal cord injury; Head and neck squamous cell carcinoma; TGF-beta receptor signaling in skeletal dysplasias; Affected pathways in Duchenne muscular dystrophy; Calcium regulation in cardiac cells; TGF-beta receptor signaling" "Potential therapeutics for SARS; mTORC1-mediated signalling; SARS-CoV-1 activates/modulates innate immune responses; TGF-beta receptor signaling activates SMADs; Calcineurin activates NFAT; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); TGFBR1 LBD Mutants in Cancer" "14" "0" "0.975" "0.835" "1.098" "1.221" "1.036" "0.877" "0.884" "1.127" "0.731" "158.4" "154.5" "132.3" "173.9" "193.3" "164.1" "138.9" "139.9" "178.5" "115.7" "" "" "" "" "" "" "" "" "" "" "83.9" "85.6" "75.7" "80.1" "104.6" "91.3" "81.7" "76.4" "100.1" "115.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6052842143076663631" "False" "High" "IsMasterProtein" "P15260" "Interferon gamma receptor 1 OS=Homo sapiens OX=9606 GN=IFNGR1 PE=1 SV=1" "0.000" "False" "4.934" "3" "1" "1" "1" "489" "54.4" "4.91" "2.78" "1" "stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf01108, Pf07140, Pf20634" "3459" "ENSG00000027697" "IFNGR1" "B4DFT7; E1P587; hsa:3459; P15260; Q53Y96" "Immune response to tuberculosis; Selective expression of chemokine receptors during T-cell polarization; Overview of interferons-mediated signaling pathway; Neuroinflammation and glutamatergic signaling; Th17 cell differentiation pathway; Inflammatory bowel disease signaling; JAK-STAT signaling in the regulation of beta cells; Type II interferon signaling" "Potential therapeutics for SARS; Regulation of IFNG signaling; IFNG signaling activates MAPKs" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2897023766042750801" "False" "High" "IsMasterProtein" "P19256" "Lymphocyte function-associated antigen 3 OS=Homo sapiens OX=9606 GN=CD58 PE=1 SV=1" "0.000" "False" "4.933" "4" "1" "1" "1" "250" "28.1" "6.76" "3.23" "1" "cell adhesion;stress response;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding" "" "965" "ENSG00000116815" "CD58" "A8K7G5; hsa:965; P19256; Q5U053; Q6IB65; Q96KI9" "" "Cell surface interactions at the vascular wall; Neutrophil degranulation" "2" "0" "1.177" "1.011" "1.144" "1.094" "1.084" "1.205" "1.155" "0.983" "0.486" "96.1" "113.1" "97.2" "110.0" "105.2" "104.2" "115.8" "111.0" "94.5" "46.7" "" "" "" "" "" "" "" "" "" "" "50.9" "62.7" "55.6" "50.6" "56.9" "58.0" "68.2" "60.6" "53.0" "46.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6971851119340033318" "False" "High" "IsMasterProtein" "Q712K3" "Ubiquitin-conjugating enzyme E2 R2 OS=Homo sapiens OX=9606 GN=UBE2R2 PE=1 SV=1" "0.000" "False" "4.933" "8" "2" "2" "2" "238" "27.1" "4.42" "6.32" "2" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00179" "54926" "ENSG00000107341" "UBE2R2" "D3DRL5; hsa:54926; Q712K3; Q9NX64" "" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2769761607326504072" "False" "High" "IsMasterProtein" "Q9Y3P9" "Rab GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RABGAP1 PE=1 SV=3" "0.000" "False" "4.926" "2" "2" "2" "2" "1069" "121.7" "5.25" "4.12" "2" "cell cycle OR cell proliferation;other biological processes" "cytosol;cytoskeleton" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00566, Pf00640, Pf12473" "23637" "ENSG00000011454" "RABGAP1" "B9A6L2; hsa:23637; Q05CW2; Q6ZMY1; Q9HA28; Q9P0E2; Q9UG67; Q9Y3P9" "" "TBC/RABGAPs" "1" "0" "0.944" "0.948" "0.992" "1.100" "1.080" "0.977" "0.993" "0.934" "1.773" "92.9" "87.7" "88.0" "92.1" "102.2" "100.4" "90.8" "92.3" "86.8" "164.7" "" "" "" "" "" "" "" "" "" "" "49.2" "48.6" "50.4" "42.4" "55.3" "55.8" "53.4" "50.4" "48.7" "164.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6656067604424276740" "False" "High" "IsMasterProtein" "O95365" "Zinc finger and BTB domain-containing protein 7A OS=Homo sapiens OX=9606 GN=ZBTB7A PE=1 SV=1" "0.000" "False" "4.923" "2" "1" "1" "1" "584" "61.4" "5.19" "2.86" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "51341" "ENSG00000178951" "ZBTB7A" "D6W619; hsa:51341; O00456; O95365; Q14D41; Q5XG86" "IL-18 signaling pathway" "" "1" "0" "1.011" "0.877" "0.936" "1.123" "0.807" "1.219" "0.811" "1.052" "2.363" "35.8" "36.2" "31.4" "33.5" "40.2" "28.9" "43.6" "29.0" "37.6" "84.5" "" "" "" "" "" "" "" "" "" "" "18.9" "20.0" "18.0" "15.4" "21.7" "16.1" "25.7" "15.8" "21.1" "84.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7216673517695953879" "False" "High" "IsMasterProtein" "Q8TDZ2" "[F-actin]-monooxygenase MICAL1 OS=Homo sapiens OX=9606 GN=MICAL1 PE=1 SV=2" "0.000" "False" "4.920" "1" "2" "2" "2" "1067" "117.8" "6.40" "5.48" "2" "cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00412, Pf01494, Pf12130" "64780" "ENSG00000135596" "MICAL1" "B7Z3R5; E1P5F0; Q7Z633; Q8IVS9; Q8TDZ2; Q96G47; Q9H6X6; Q9H7I0; Q9HAA1; Q9UFF7" "" "Factors involved in megakaryocyte development and platelet production" "1" "0" "1.154" "1.062" "0.891" "0.971" "1.127" "1.063" "0.808" "1.077" "3.865" "117.6" "135.7" "124.9" "104.7" "114.2" "132.6" "125.0" "95.0" "126.6" "454.5" "" "" "" "" "" "" "" "" "" "" "62.3" "75.2" "71.6" "48.2" "61.8" "73.7" "73.6" "51.9" "71.0" "454.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4765552648658305889" "False" "High" "IsMasterProtein" "Q96JH7" "Deubiquitinating protein VCPIP1 OS=Homo sapiens OX=9606 GN=VCPIP1 PE=1 SV=2" "0.000" "False" "4.919" "1" "1" "1" "1" "1222" "134.2" "7.20" "3.93" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02338, Pf19437, Pf21403" "80124" "ENSG00000175073" "VCPIP1" "hsa:80124; Q504T4; Q86T93; Q86W01; Q8N3A9; Q96JH7; Q9H5R8" "Alstrom syndrome" "Ovarian tumor domain proteases" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3357604607996684691" "False" "High" "IsMasterProtein" "Q9NX58" "Cell growth-regulating nucleolar protein OS=Homo sapiens OX=9606 GN=LYAR PE=1 SV=3" "0.000" "False" "4.912" "2" "1" "1" "1" "379" "43.6" "9.57" "3.91" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08790, Pf17848" "55646" "ENSG00000145220" "LYAR" "D3DVS4; hsa:55646; Q6FI78; Q9NX58; Q9NYS1" "" "" "0" "0" "1.134" "1.154" "1.340" "1.400" "1.389" "2.800" "2.848" "3.289" "0.966" "82.3" "93.3" "95.0" "110.3" "115.2" "114.3" "230.4" "234.3" "270.6" "79.5" "" "" "" "" "" "" "" "" "" "" "43.6" "51.7" "54.4" "50.8" "62.3" "63.6" "135.6" "127.9" "151.8" "79.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1245532746290238029" "False" "High" "IsMasterProtein" "P61353" "Large ribosomal subunit protein eL27 OS=Homo sapiens OX=9606 GN=RPL27 PE=1 SV=2" "0.000" "False" "4.912" "13" "2" "2" "2" "136" "15.8" "10.56" "5.26" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00467, Pf01777" "6155" "ENSG00000131469" "RPL27" "hsa:6155; P08526; P61353; Q4G0A9" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "0.819" "1.135" "1.381" "0.873" "1.247" "0.798" "0.953" "0.821" "1.119" "174.8" "143.2" "198.5" "241.4" "152.6" "218.0" "139.4" "166.5" "143.5" "195.6" "" "" "" "" "" "" "" "" "" "" "92.6" "79.4" "113.7" "111.2" "82.6" "121.3" "82.1" "90.9" "80.5" "195.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6528342238616596443" "False" "High" "IsMasterProtein" "Q92542" "Nicastrin OS=Homo sapiens OX=9606 GN=NCSTN PE=1 SV=2" "0.000" "False" "4.908" "2" "1" "1" "1" "709" "78.4" "5.99" "3.05" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05450, Pf18266" "23385" "ENSG00000162736" "NCSTN" "hsa:23385; Q5T207; Q5T208; Q86VV5; Q92542" "Alzheimer's disease and miRNA effects; Notch signaling; Inclusion body myositis; Alzheimer's disease; DYRK1A involvement regarding cell proliferation in brain development; Notch signaling pathway" "Neutrophil degranulation; Amyloid fiber formation; Degradation of the extracellular matrix; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; Nuclear signaling by ERBB4; EPH-ephrin mediated repulsion of cells; NOTCH4 Activation and Transmission of Signal to the Nucleus; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; Noncanonical activation of NOTCH3" "20" "0" "0.974" "0.873" "0.973" "1.145" "0.927" "0.987" "1.009" "0.878" "0.756" "81.4" "79.2" "71.1" "79.2" "93.1" "75.4" "80.3" "82.1" "71.5" "61.5" "" "" "" "" "" "" "" "" "" "" "43.1" "43.9" "40.7" "36.5" "50.4" "41.9" "47.3" "44.8" "40.1" "61.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6391839617332390225" "False" "High" "IsMasterProtein" "P07203" "Glutathione peroxidase 1 OS=Homo sapiens OX=9606 GN=GPX1 PE=1 SV=4" "0.000" "False" "4.903" "14" "2" "2" "2" "203" "22.1" "6.55" "2.79" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00255" "2876" "ENSG00000233276" "GPX1" "E9PAS1; hsa:2876; P07203; Q7Z5H1; Q9BW12" "Glutathione metabolism; Selenium micronutrient network; Folate metabolism; Amyotrophic lateral sclerosis (ALS); Trans-sulfuration, one-carbon metabolism and related pathways; Selenium metabolism and selenoproteins; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; One-carbon metabolism and related pathways; TYROBP causal network in microglia; Oxidative stress response; Male infertility; p53 transcriptional gene network; Omega-6-fatty acids in senescence" "Detoxification of Reactive Oxygen Species; Synthesis of 15-eicosatetraenoic acid derivatives; Synthesis of 12-eicosatetraenoic acid derivatives; Synthesis of 5-eicosatetraenoic acids" "18" "0" "1.154" "0.954" "1.142" "1.127" "1.057" "1.178" "0.855" "0.886" "0.654" "77.2" "89.1" "73.7" "88.2" "87.0" "81.6" "91.0" "66.0" "68.4" "50.5" "" "" "" "" "" "" "" "" "" "" "40.9" "49.4" "42.2" "40.6" "47.1" "45.4" "53.5" "36.0" "38.4" "50.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1703725255333180782" "False" "High" "IsMasterProtein" "O14530" "Thioredoxin domain-containing protein 9 OS=Homo sapiens OX=9606 GN=TXNDC9 PE=1 SV=2" "0.000" "False" "4.898" "8" "2" "2" "2" "226" "26.5" "5.88" "4.96" "2" "cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf00085" "10190" "ENSG00000115514" "TXNDC9" "B2R9G8; D3DVI4; hsa:10190; O14530; Q53HG4; Q53RV8; Q6NSF5; Q8TB70; Q9BRU6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3143517004493314389" "False" "High" "IsMasterProtein" "Q01970" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 OS=Homo sapiens OX=9606 GN=PLCB3 PE=1 SV=2" "0.000" "False" "4.898" "1" "1" "1" "1" "1234" "138.7" "5.90" "3.62" "1" "other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00168, Pf00387, Pf00388, Pf08703, Pf09279, Pf17787" "5331" "ENSG00000149782" "PLCB3" "A5PKZ6; G5E960; hsa:5331; Q01970; Q8N1A4" "Alzheimer's disease and miRNA effects; S1P receptor signal transduction; Myometrial relaxation and contraction pathways; G protein signaling pathways; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; GPR40 pathway; MAPK cascade; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; Hippo signaling regulation pathways; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Neuroinflammation and glutamatergic signaling; Alzheimer's disease; Calcium regulation in cardiac cells" "G alpha (q) signalling events; Synthesis of IP3 and IP4 in the cytosol; Ca2+ pathway; G beta:gamma signalling through PLC beta; Presynaptic function of Kainate receptors; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion; PLC beta mediated events; Acetylcholine regulates insulin secretion" "26" "0" "1.052" "1.022" "1.061" "1.081" "1.142" "1.021" "1.015" "0.994" "0.939" "165.6" "174.1" "169.2" "175.7" "179.0" "189.0" "169.0" "168.0" "164.5" "155.5" "" "" "" "" "" "" "" "" "" "" "87.7" "96.5" "96.9" "80.9" "96.8" "105.1" "99.5" "91.7" "92.3" "155.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3805240560895531655" "False" "High" "IsMasterProtein" "Q15532" "Protein SSXT OS=Homo sapiens OX=9606 GN=SS18 PE=1 SV=3" "0.000" "False" "4.895" "2" "1" "1" "1" "418" "45.9" "6.46" "3.74" "1" "cell organization and biogenesis;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05030" "6760" "ENSG00000141380" "SS18" "B0YJ95; hsa:6760; Q15532; Q16404; Q4VAX1; Q9BXC6" "" "" "0" "0" "0.919" "1.068" "0.952" "1.031" "0.910" "1.091" "0.795" "0.963" "2.437" "186.6" "171.6" "199.3" "177.7" "192.4" "169.9" "203.7" "148.4" "179.6" "454.7" "" "" "" "" "" "" "" "" "" "" "98.8" "95.1" "114.2" "81.9" "104.1" "94.5" "119.9" "81.0" "100.8" "454.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5461850800476976864" "False" "High" "IsMasterProtein" "Q9UBB5" "Methyl-CpG-binding domain protein 2 OS=Homo sapiens OX=9606 GN=MBD2 PE=1 SV=1" "0.000" "False" "4.883" "4" "2" "2" "1" "411" "43.2" "10.04" "5.40" "2" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01429, Pf14048, Pf16564" "8932" "ENSG00000134046" "MBD2" "hsa:8932; O95242; Q9UBB5; Q9UIS8" "Effect of progerin on genes involved in progeria" "NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Opening" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2740233867527592751" "False" "High" "IsMasterProtein" "Q5M775" "Cytospin-B OS=Homo sapiens OX=9606 GN=SPECC1 PE=1 SV=1" "0.000" "False" "4.872" "2" "2" "2" "1" "1068" "118.5" "6.70" "3.06" "2" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf00307" "92521" "ENSG00000128487" "SPECC1" "B4DHH0; B7WNS8; hsa:92521; Q5IBP1; Q5IBP2; Q5IBP3; Q5IBP4; Q5M772; Q5M773; Q5M774; Q5M775; Q86XT8; Q8N4U4; Q8WU84; Q9HCQ3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7256809200695467141" "False" "High" "IsMasterProtein" "Q02083" "N-acylethanolamine-hydrolyzing acid amidase OS=Homo sapiens OX=9606 GN=NAAA PE=1 SV=3" "0.000" "False" "4.870" "4" "2" "2" "2" "359" "40.0" "8.75" "5.41" "2" "other metabolic processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02275, Pf15508" "27163" "ENSG00000138744" "NAAA" "hsa:27163; Q02083; Q5KTF2; Q96EY2; Q9BRA8" "" "Neurotransmitter release cycle" "1" "0" "1.138" "1.168" "1.184" "1.118" "1.117" "1.245" "1.201" "1.150" "0.771" "241.2" "274.4" "281.8" "285.5" "269.6" "269.6" "300.4" "289.6" "277.5" "186.0" "" "" "" "" "" "" "" "" "" "" "127.7" "152.1" "161.4" "131.5" "145.9" "149.9" "176.8" "158.1" "155.7" "186.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4941414792679987409" "False" "High" "IsMasterProtein" "Q00403" "Transcription initiation factor IIB OS=Homo sapiens OX=9606 GN=GTF2B PE=1 SV=1" "0.000" "False" "4.861" "3" "1" "2" "1" "316" "34.8" "8.35" "5.61" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00382, Pf08271" "2959" "ENSG00000137947" "GTF2B" "A8K1A7; hsa:2959; Q00403; Q5JS30" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "10" "0" "1.905" "0.942" "1.494" "2.602" "2.643" "1.882" "1.160" "1.747" "5.455" "37.3" "71.1" "35.2" "55.8" "97.1" "98.6" "70.2" "43.3" "65.2" "203.6" "" "" "" "" "" "" "" "" "" "" "19.8" "39.4" "20.1" "25.7" "52.6" "54.9" "41.3" "23.6" "36.6" "203.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6498746836985135124" "False" "High" "IsMasterProtein" "C9J7I0" "UBAP1-MVB12-associated (UMA)-domain containing protein 1 OS=Homo sapiens OX=9606 GN=UMAD1 PE=1 SV=2" "0.000" "False" "4.854" "10" "1" "1" "1" "137" "15.2" "4.48" "3.19" "1" "" "" "" "" "729852" "ENSG00000219545" "UMAD1" "A4D104; C9J7I0; hsa:729852" "" "" "0" "0" "1.142" "1.194" "1.042" "0.976" "0.973" "1.137" "1.043" "0.911" "1.016" "71.2" "81.3" "85.1" "74.3" "69.5" "69.3" "81.0" "74.3" "64.9" "72.4" "" "" "" "" "" "" "" "" "" "" "37.7" "45.1" "48.7" "34.2" "37.6" "38.6" "47.7" "40.6" "36.4" "72.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3249380285139605434" "False" "High" "IsMasterProtein" "Q96CB9" "5-methylcytosine rRNA methyltransferase NSUN4 OS=Homo sapiens OX=9606 GN=NSUN4 PE=1 SV=2" "0.000" "False" "4.850" "3" "1" "1" "1" "384" "43.1" "8.18" "3.19" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf01189" "387338" "ENSG00000117481" "NSUN4" "A8K6S6; B3KQ50; B4DHA4; hsa:387338; Q5TDF7; Q96AN8; Q96CB9; Q9HAJ8" "" "rRNA modification in the mitochondrion" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2722320561760144151" "False" "High" "IsMasterProtein" "Q6GPH4" "XIAP-associated factor 1 OS=Homo sapiens OX=9606 GN=XAF1 PE=1 SV=1" "0.000" "False" "4.844" "5" "2" "2" "2" "301" "34.6" "8.19" "6.35" "2" "other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf18608, Pf21366" "54739" "ENSG00000132530" "XAF1" "A2T931; A2T932; A8K2L1; A8K9Y3; D3DTM6; hsa:54739; Q6GPH4; Q6MZE8; Q8N557; Q99982" "Copper homeostasis" "Interferon alpha/beta signaling" "2" "0" "0.964" "1.028" "1.010" "0.992" "0.882" "0.887" "0.950" "0.964" "0.798" "345.4" "332.9" "355.0" "348.9" "342.7" "304.5" "306.3" "328.3" "333.1" "275.6" "" "" "" "" "" "" "" "" "" "" "182.9" "184.6" "203.3" "160.7" "185.4" "169.4" "180.3" "179.2" "186.9" "275.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6720248987179001386" "False" "High" "IsMasterProtein" "O60313" "Dynamin-like GTPase OPA1, mitochondrial OS=Homo sapiens OX=9606 GN=OPA1 PE=1 SV=3" "0.000" "False" "4.838" "2" "2" "2" "2" "960" "111.6" "7.87" "4.96" "2" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00350, Pf19434" "4976" "ENSG00000198836" "OPA1" "D3DNW4; E5KLJ5; E5KLJ6; E5KLJ7; E5KLK1; E5KLK2; hsa:4976; O60313" "Orexin receptor pathway" "Mitochondrial protein degradation; Regulation of Apoptosis" "3" "0" "0.907" "0.976" "0.962" "0.987" "0.952" "0.762" "0.962" "0.930" "1.191" "102.3" "92.8" "99.9" "98.4" "101.0" "97.4" "78.0" "98.4" "95.2" "121.9" "" "" "" "" "" "" "" "" "" "" "54.2" "51.4" "57.2" "45.3" "54.7" "54.2" "45.9" "53.7" "53.4" "121.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3997402182379015815" "False" "High" "IsMasterProtein" "O15371" "Eukaryotic translation initiation factor 3 subunit D OS=Homo sapiens OX=9606 GN=EIF3D PE=1 SV=1" "0.000" "False" "4.832" "2" "1" "1" "1" "548" "63.9" "6.05" "3.60" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf05091" "8664" "ENSG00000100353" "EIF3D" "A8MWD3; B2R7D4; B4DTF8; B4DVY1; hsa:8664; O15371; Q3MJD9; Q5M9Q6" "Translation factors; VEGFA-VEGFR2 signaling; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "9" "0" "0.926" "1.011" "1.059" "0.946" "0.948" "0.880" "0.428" "0.771" "6.483" "137.1" "126.9" "138.5" "145.2" "129.6" "129.9" "120.6" "58.7" "105.7" "888.6" "" "" "" "" "" "" "" "" "" "" "72.6" "70.3" "79.3" "66.8" "70.1" "72.3" "70.9" "32.0" "59.3" "888.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1244063578202926483" "False" "High" "IsMasterProtein" "Q68D10" "Protein SPT2 homolog OS=Homo sapiens OX=9606 GN=SPTY2D1 PE=1 SV=3" "0.000" "False" "4.830" "1" "1" "2" "1" "685" "75.6" "9.79" "5.90" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf08243" "144108" "ENSG00000179119" "SPTY2D1" "hsa:144108; Q68D10; Q6AWA5; Q6MZI5; Q7Z390; Q7Z470; Q86VG8; Q8N3E7; Q8N417; Q8N8I3" "" "" "0" "0" "1.051" "1.048" "1.194" "1.160" "1.044" "1.383" "1.307" "1.483" "2.978" "288.6" "303.3" "302.4" "344.5" "334.6" "301.2" "399.2" "377.2" "428.0" "859.5" "" "" "" "" "" "" "" "" "" "" "152.8" "168.2" "173.2" "158.7" "181.0" "167.5" "234.9" "205.9" "240.1" "859.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2146106311129589736" "False" "High" "IsMasterProtein" "P35244" "Replication protein A 14 kDa subunit OS=Homo sapiens OX=9606 GN=RPA3 PE=1 SV=1" "0.000" "False" "4.829" "21" "2" "2" "2" "121" "13.6" "5.08" "1.93" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf08661" "6119" "ENSG00000106399" "RPA3" "hsa:6119; P35244; Q549U6" "Retinoblastoma gene in cancer; G1 to S cell cycle control; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "HSF1 activation; Fanconi Anemia Pathway; Regulation of HSF1-mediated heat shock response; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Meiotic recombination; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "36" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7779362395337591117" "False" "High" "IsMasterProtein" "Q96FX7" "tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A OS=Homo sapiens OX=9606 GN=TRMT61A PE=1 SV=1" "0.000" "False" "4.829" "9" "1" "2" "1" "289" "31.4" "7.36" "6.06" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf08704" "115708" "ENSG00000166166" "TRMT61A" "A6NN78; hsa:115708; Q8N7Q9; Q96FX7" "" "tRNA modification in the nucleus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1981774019348378929" "False" "High" "IsMasterProtein" "P0DOY2" "Immunoglobulin lambda constant 2 OS=Homo sapiens OX=9606 GN=IGLC2 PE=1 SV=1" "0.000" "False" "4.827" "9" "1" "1" "1" "106" "11.3" "7.24" "3.92" "1" "other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf07654" "" "ENSG00000211677" "IGLC2" "A0A075B6K9; A0M8Q4; P0CG05; P0CG06; P0DOY2; P80423" "" "FCERI mediated NF-kB activation; Potential therapeutics for SARS; Cell surface interactions at the vascular wall; FCGR activation; Role of LAT2/NTAL/LAB on calcium mobilization; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Initial triggering of complement; Classical antibody-mediated complement activation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Scavenging of heme from plasma; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; CD22 mediated BCR regulation; Regulation of Complement cascade" "19" "0" "0.982" "1.008" "0.828" "0.873" "0.766" "0.775" "0.755" "0.807" "1.227" "279.1" "274.0" "281.3" "231.1" "243.7" "213.7" "216.2" "210.6" "225.4" "342.4" "" "" "" "" "" "" "" "" "" "" "147.8" "151.9" "161.1" "106.4" "131.8" "118.9" "127.3" "115.0" "126.4" "342.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8852337030398889599" "False" "High" "IsMasterProtein" "C9JRZ8" "Aldo-keto reductase family 1 member B15 OS=Homo sapiens OX=9606 GN=AKR1B15 PE=1 SV=2" "0.000" "False" "4.809" "8" "2" "2" "1" "316" "36.5" "6.70" "4.79" "2" "other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00248" "441282" "ENSG00000227471" "AKR1B15" "C9J3V2; C9JRZ8; hsa:441282" "" "Estrogen biosynthesis" "1" "0" "1.044" "1.217" "1.171" "1.205" "1.269" "1.108" "1.342" "1.421" "0.538" "127.2" "132.8" "154.9" "149.0" "153.3" "161.4" "140.9" "170.8" "180.8" "68.4" "" "" "" "" "" "" "" "" "" "" "67.4" "73.6" "88.7" "68.6" "82.9" "89.8" "82.9" "93.2" "101.4" "68.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5593036104782441701" "False" "High" "IsMasterProtein" "Q8NCF5" "NFATC2-interacting protein OS=Homo sapiens OX=9606 GN=NFATC2IP PE=1 SV=1" "0.000" "False" "4.797" "4" "1" "1" "1" "419" "45.8" "6.60" "2.73" "1" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf11976" "84901" "ENSG00000176953" "NFATC2IP" "B7Z4G5; hsa:84901; Q66K34; Q6NVK1; Q8NCF5; Q8NFR2; Q96ST9" "16p11.2 distal deletion syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-421989768094974956" "False" "High" "IsMasterProtein" "Q96BM9" "ADP-ribosylation factor-like protein 8A OS=Homo sapiens OX=9606 GN=ARL8A PE=1 SV=1" "0.000" "False" "4.796" "5" "1" "1" "1" "186" "21.4" "7.77" "3.12" "1" "cell cycle OR cell proliferation;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00025" "127829" "ENSG00000143862" "ARL8A" "B3KXD0; hsa:127829; Q96BM9" "" "Neutrophil degranulation" "1" "0" "0.928" "0.962" "0.955" "0.972" "0.979" "1.039" "1.021" "0.887" "0.578" "212.7" "197.4" "204.7" "203.1" "206.7" "208.2" "220.9" "217.3" "188.6" "123.0" "" "" "" "" "" "" "" "" "" "" "112.6" "109.4" "117.3" "93.5" "111.8" "115.8" "130.0" "118.6" "105.8" "123.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6957065747657519198" "False" "High" "IsMasterProtein" "P33552" "Cyclin-dependent kinases regulatory subunit 2 OS=Homo sapiens OX=9606 GN=CKS2 PE=1 SV=1" "0.000" "False" "4.793" "20" "2" "3" "1" "79" "9.9" "8.46" "7.89" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf01111" "1164" "ENSG00000123975" "CKS2" "hsa:1164; P33552; Q6FGI9; Q6LET5" "Small cell lung cancer" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1492167490634941437" "False" "High" "IsMasterProtein" "P49914" "5-formyltetrahydrofolate cyclo-ligase OS=Homo sapiens OX=9606 GN=MTHFS PE=1 SV=2" "0.000" "False" "4.792" "12" "2" "2" "2" "203" "23.2" "7.88" "0.00" "2" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf01812" "10588" "ENSG00000136371" "MTHFS" "H3BQ75; hsa:10588; P49914" "Folate metabolism; One-carbon metabolism; Disorders of folate metabolism and transport" "Metabolism of folate and pterines" "4" "0" "0.907" "0.730" "1.476" "1.159" "0.818" "1.264" "0.948" "0.809" "0.896" "28.4" "25.7" "20.7" "41.9" "32.9" "23.2" "35.9" "26.9" "22.9" "25.4" "" "" "" "" "" "" "" "" "" "" "15.0" "14.3" "11.9" "19.3" "17.8" "12.9" "21.1" "14.7" "12.9" "25.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4743606762570339993" "False" "High" "IsMasterProtein" "P43403" "Tyrosine-protein kinase ZAP-70 OS=Homo sapiens OX=9606 GN=ZAP70 PE=1 SV=1" "0.000" "False" "4.791" "5" "3" "3" "2" "619" "69.8" "7.69" "3.27" "3" "cell adhesion;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00017, Pf07714" "7535" "ENSG00000115085; ENSG00000291603" "ZAP70" "A6NFP4; P43403; Q6PIA4; Q8IXD6; Q9UBS6" "Prolactin signaling pathway; T cell receptor and co-stimulatory signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Ras signaling; MicroRNA network associated with chronic lymphocytic leukemia; Inflammatory response pathway; Cancer immunotherapy by PD-1 blockade; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Modulators of TCR signaling and T cell activation; Network map of SARS-CoV-2 signaling pathway; Th17 cell differentiation pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis; Interferon type I signaling pathways; T-cell receptor signaling pathway" "Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; RHOH GTPase cycle; Nuclear events stimulated by ALK signaling in cancer" "18" "0" "1.055" "0.878" "0.983" "1.081" "0.830" "0.900" "0.154" "0.717" "9.455" "20.7" "21.8" "18.2" "20.3" "22.4" "17.2" "18.6" "3.2" "14.8" "195.6" "" "" "" "" "" "" "" "" "" "" "11.0" "12.1" "10.4" "9.4" "12.1" "9.6" "11.0" "1.7" "8.3" "195.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6452221919959736930" "False" "High" "IsMasterProtein" "O75122" "CLIP-associating protein 2 OS=Homo sapiens OX=9606 GN=CLASP2 PE=1 SV=3" "0.000" "False" "4.790" "2" "2" "2" "2" "1294" "141.0" "8.40" "5.13" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf12348, Pf21040" "23122" "ENSG00000163539" "CLASP2" "B2RTR1; F5H604; hsa:23122; O75122; Q7L8F6; Q8N6R6; Q9BQT3; Q9BQT4; Q9H7A3; Q9NSZ2" "7q11.23 copy number variation syndrome" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Role of ABL in ROBO-SLIT signaling" "8" "0" "1.058" "1.007" "1.136" "1.140" "1.059" "1.439" "1.351" "1.442" "4.473" "132.8" "140.4" "133.8" "150.9" "151.3" "140.6" "191.1" "179.4" "191.4" "593.9" "" "" "" "" "" "" "" "" "" "" "70.3" "77.8" "76.6" "69.5" "81.9" "78.2" "112.5" "97.9" "107.4" "593.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3443446084982214279" "False" "High" "IsMasterProtein" "Q9UN37" "Vacuolar protein sorting-associated protein 4A OS=Homo sapiens OX=9606 GN=VPS4A PE=1 SV=1" "0.000" "False" "4.778" "2" "1" "1" "1" "437" "48.9" "7.80" "3.23" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00004, Pf04212, Pf09336, Pf17862" "27183" "ENSG00000132612" "VPS4A" "B2RCB7; hsa:27183; Q8TF07; Q9UI03; Q9UN37; Q9Y582" "Ebola virus infection in host; Ciliary landscape" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III" "6" "0" "1.206" "1.137" "0.903" "1.280" "1.004" "0.751" "0.183" "0.803" "10.353" "27.7" "33.4" "31.5" "25.0" "35.4" "27.8" "20.8" "5.1" "22.2" "286.7" "" "" "" "" "" "" "" "" "" "" "14.7" "18.5" "18.0" "11.5" "19.2" "15.5" "12.2" "2.8" "12.5" "286.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5593923735961542225" "False" "High" "IsMasterProtein" "Q9BRG1" "Vacuolar protein-sorting-associated protein 25 OS=Homo sapiens OX=9606 GN=VPS25 PE=1 SV=1" "0.000" "False" "4.776" "6" "1" "1" "1" "176" "20.7" "6.34" "3.52" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05871" "84313" "ENSG00000131475" "VPS25" "B2R581; hsa:84313; Q9BRG1" "" "HCMV Late Events; Endosomal Sorting Complex Required For Transport (ESCRT)" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3559199072785365377" "False" "High" "IsMasterProtein" "Q14493" "Histone RNA hairpin-binding protein OS=Homo sapiens OX=9606 GN=SLBP PE=1 SV=1" "0.000" "False" "4.774" "6" "2" "4" "2" "270" "31.3" "7.47" "8.97" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15247" "7884" "ENSG00000163950" "SLBP" "B3KRJ5; hsa:7884; Q14493" "8p23.1 copy number variation syndrome; 4p16.3 copy number variation" "RNA Polymerase II Transcription Termination; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; Transport of the SLBP Dependant Mature mRNA" "5" "0" "0.937" "0.870" "0.673" "0.891" "0.891" "0.855" "0.805" "0.827" "1.196" "368.5" "345.4" "320.6" "248.1" "328.2" "328.3" "315.0" "296.7" "304.8" "440.6" "" "" "" "" "" "" "" "" "" "" "195.1" "191.5" "183.6" "114.2" "177.6" "182.6" "185.4" "161.9" "171.0" "440.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1677934760849169098" "False" "High" "IsMasterProtein" "Q8IVH4" "Methylmalonic aciduria type A protein, mitochondrial OS=Homo sapiens OX=9606 GN=MMAA PE=1 SV=1" "0.000" "False" "4.773" "2" "1" "2" "1" "418" "46.5" "9.29" "3.43" "1" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf03308" "166785" "ENSG00000151611" "MMAA" "B3KX40; hsa:166785; Q495G7; Q8IVH4" "" "Propionyl-CoA catabolism; Defective MMAA causes MMA, cblA type; Defective MUT causes MMAM; Cobalamin (Cbl) metabolism" "4" "0" "0.976" "1.011" "1.029" "1.009" "0.984" "1.008" "0.914" "0.888" "1.121" "254.1" "248.0" "256.9" "261.5" "256.4" "250.1" "256.2" "232.3" "225.7" "284.8" "" "" "" "" "" "" "" "" "" "" "134.5" "137.5" "147.1" "120.4" "138.7" "139.1" "150.8" "126.8" "126.6" "284.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5805697236743296122" "False" "High" "IsMasterProtein" "Q96QU8" "Exportin-6 OS=Homo sapiens OX=9606 GN=XPO6 PE=1 SV=1" "0.000" "False" "4.772" "1" "1" "1" "1" "1125" "128.8" "6.35" "3.21" "1" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03810, Pf08389" "23214" "ENSG00000169180" "XPO6" "A1L3W4; D3DWF9; hsa:23214; Q2YDX3; Q53G88; Q68G50; Q76N88; Q96CP8; Q96QU8; Q9BT21" "" "" "0" "0" "1.314" "1.080" "1.363" "1.216" "1.090" "1.303" "0.480" "1.202" "6.097" "42.5" "55.9" "45.9" "58.0" "51.7" "46.4" "55.4" "20.4" "51.1" "259.4" "" "" "" "" "" "" "" "" "" "" "22.5" "31.0" "26.3" "26.7" "28.0" "25.8" "32.6" "11.2" "28.7" "259.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1908933075179858623" "False" "High" "IsMasterProtein" "Cont_A2I7N3" "Serpin A3-7 OS=Bos taurus OX=9913 GN=SERPINA3-7 PE=3 SV=1" "0.000" "True" "4.756" "3" "2" "3" "2" "417" "46.9" "6.34" "8.20" "2" "" "non-structural extracellular;other cell component" "enzyme regulator activity" "Pf00079" "" "" "SERPINA3-7" "A2I7N3" "" "" "0" "0" "1.173" "1.115" "0.926" "1.187" "1.330" "1.198" "1.227" "1.466" "0.598" "285.0" "334.2" "317.8" "264.0" "338.4" "379.0" "341.5" "349.5" "417.8" "170.4" "" "" "" "" "" "" "" "" "" "" "150.9" "185.3" "182.0" "121.6" "183.1" "210.8" "201.0" "190.8" "234.4" "170.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "549572925276105069" "False" "High" "IsMasterProtein" "P11274" "Breakpoint cluster region protein OS=Homo sapiens OX=9606 GN=BCR PE=1 SV=2" "0.000" "False" "4.753" "2" "2" "2" "2" "1271" "142.7" "7.03" "4.16" "2" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00168, Pf00620, Pf00621, Pf09036, Pf19057" "613" "ENSG00000186716" "BCR" "hsa:613; P11274; P78501; Q12842; Q4LE80; Q6NZI3" "Imatinib and chronic myeloid leukemia; Extrafollicular and follicular B cell activation by SARS-CoV-2" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "11" "0" "1.010" "1.068" "1.461" "0.954" "0.949" "1.416" "1.335" "1.367" "3.291" "21.9" "22.1" "23.4" "32.0" "20.9" "20.8" "31.0" "29.2" "29.9" "72.0" "" "" "" "" "" "" "" "" "" "" "11.6" "12.2" "13.4" "14.7" "11.3" "11.5" "18.2" "15.9" "16.8" "72.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3754812835242028685" "False" "High" "IsMasterProtein" "Q6ZSR9" "Uncharacterized protein FLJ45252 OS=Homo sapiens OX=9606 PE=1 SV=2" "0.000" "False" "4.745" "5" "1" "1" "1" "355" "38.0" "5.26" "3.81" "1" "" "" "" "Pf15282" "" "" "" "" "" "" "0" "0" "1.505" "1.108" "1.331" "1.053" "1.238" "1.451" "1.103" "1.128" "0.870" "39.9" "60.1" "44.3" "53.1" "42.0" "49.4" "58.0" "44.1" "45.1" "34.8" "" "" "" "" "" "" "" "" "" "" "21.1" "33.3" "25.3" "24.5" "22.7" "27.5" "34.1" "24.1" "25.3" "34.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9151780766463194199" "False" "High" "IsMasterProtein" "P24863" "Cyclin-C OS=Homo sapiens OX=9606 GN=CCNC PE=1 SV=2" "0.000" "False" "4.744" "4" "1" "1" "1" "283" "33.2" "7.33" "3.13" "1" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00134, Pf16899" "892" "ENSG00000112237" "CCNC" "B4DPZ1; hsa:892; P24863; Q9H543" "Vitamin D receptor pathway" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH1 Intracellular Domain Regulates Transcription" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1239746035430338710" "False" "High" "IsMasterProtein" "Q2T9J0" "Peroxisomal leader peptide-processing protease OS=Homo sapiens OX=9606 GN=TYSND1 PE=1 SV=3" "0.000" "False" "4.732" "2" "1" "1" "1" "566" "59.3" "6.20" "3.16" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf13365" "219743" "ENSG00000156521" "TYSND1" "hsa:219743; Q2T9J0; Q5SQT4; Q5SQU1; Q8N6H2; Q96AR5" "" "TYSND1 cleaves peroxisomal proteins" "2" "0" "1.168" "1.145" "1.247" "1.438" "1.102" "1.236" "1.058" "0.966" "0.818" "86.1" "100.6" "98.6" "107.3" "123.8" "94.9" "106.4" "91.1" "83.2" "70.4" "" "" "" "" "" "" "" "" "" "" "45.6" "55.8" "56.5" "49.4" "67.0" "52.8" "62.6" "49.7" "46.6" "70.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4255183124898333384" "False" "High" "IsMasterProtein" "Q9Y6G5" "COMM domain-containing protein 10 OS=Homo sapiens OX=9606 GN=COMMD10 PE=1 SV=1" "0.000" "False" "4.729" "6" "1" "1" "1" "202" "23.0" "6.54" "2.91" "1" "" "nucleus;other cell component" "" "Pf07258, Pf21672" "51397" "ENSG00000145781" "COMMD10" "D3DT07; hsa:51397; Q9P077; Q9Y6G5" "" "Neddylation" "1" "0" "1.258" "1.183" "1.170" "1.256" "1.373" "1.405" "1.185" "1.387" "1.079" "57.6" "72.4" "68.1" "67.4" "72.3" "79.1" "80.9" "68.2" "79.9" "62.1" "" "" "" "" "" "" "" "" "" "" "30.5" "40.2" "39.0" "31.0" "39.1" "44.0" "47.6" "37.2" "44.8" "62.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8271257472643545210" "False" "High" "IsMasterProtein" "Q6PCE3" "Glucose 1,6-bisphosphate synthase OS=Homo sapiens OX=9606 GN=PGM2L1 PE=1 SV=3" "0.000" "False" "4.720" "2" "2" "3" "1" "622" "70.4" "7.15" "8.28" "2" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf02878, Pf02879, Pf02880" "283209" "ENSG00000165434" "PGM2L1" "hsa:283209; Q6PCE3; Q96MQ7; Q9UIK3" "" "Glycolysis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5469843517911814877" "False" "High" "IsMasterProtein" "Q969S8" "Polyamine deacetylase HDAC10 OS=Homo sapiens OX=9606 GN=HDAC10 PE=1 SV=1" "0.000" "False" "4.718" "2" "2" "2" "2" "669" "71.4" "5.74" "5.87" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00850" "83933" "ENSG00000100429" "HDAC10" "hsa:83933; Q08AP4; Q6STF9; Q969S8; Q96P77; Q96P78; Q9H028; Q9UGX1; Q9UGX2" "Neural crest differentiation; Ectoderm differentiation; Ectoderm differentiation; Ethanol effects on histone modifications" "Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; HDACs deacetylate histones; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway" "9" "0" "0.928" "0.916" "0.941" "0.976" "0.942" "0.964" "0.961" "0.916" "0.924" "421.9" "391.6" "386.3" "396.8" "411.5" "397.6" "406.8" "405.2" "386.2" "389.7" "" "" "" "" "" "" "" "" "" "" "223.4" "217.1" "221.2" "182.8" "222.7" "221.1" "239.4" "221.2" "216.7" "389.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1635726356787300158" "False" "High" "IsMasterProtein" "Q7LDG7" "RAS guanyl-releasing protein 2 OS=Homo sapiens OX=9606 GN=RASGRP2 PE=1 SV=1" "0.000" "False" "4.711" "2" "1" "1" "1" "609" "69.2" "7.80" "2.86" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00130, Pf00617, Pf00618, Pf13202" "10235" "ENSG00000068831" "RASGRP2" "A6NDC7; hsa:10235; O00538; Q7LDG7; Q9UL65" "MAPK signaling pathway; Chemokine signaling pathway; Ras signaling" "Integrin signaling; Rap1 signalling; FCERI mediated NF-kB activation; Effects of PIP2 hydrolysis" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3192969394575095847" "False" "High" "IsMasterProtein" "Q9BT17" "Mitochondrial ribosome-associated GTPase 1 OS=Homo sapiens OX=9606 GN=MTG1 PE=1 SV=2" "0.000" "False" "4.696" "5" "2" "2" "2" "334" "37.2" "9.47" "5.08" "2" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf01926" "92170" "ENSG00000148824" "MTG1" "hsa:92170; Q5VWX8; Q6PIY9; Q8IYJ4; Q8NC48; Q9BT17; Q9BVU8" "" "" "0" "0" "1.117" "0.988" "1.074" "1.148" "1.131" "1.072" "0.832" "0.983" "1.073" "85.9" "95.9" "84.8" "92.3" "98.6" "97.2" "92.0" "71.4" "84.4" "92.2" "" "" "" "" "" "" "" "" "" "" "45.5" "53.2" "48.6" "42.5" "53.4" "54.1" "54.2" "39.0" "47.4" "92.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1858767456070720034" "False" "High" "IsMasterProtein" "P55735" "Protein SEC13 homolog OS=Homo sapiens OX=9606 GN=SEC13 PE=1 SV=3" "0.000" "False" "4.688" "3" "1" "1" "1" "322" "35.5" "5.48" "3.01" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "6396" "ENSG00000157020" "SEC13" "A8MV37; B4DXJ1; hsa:6396; P55735; Q5BJF0; Q9BRM6; Q9BUG7" "Sterol regulatory element-binding proteins (SREBP) signaling" "ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; snRNP Assembly; Regulation of HSF1-mediated heat shock response; Separation of Sister Chromatids; MHC class II antigen presentation; HCMV Late Events; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; Amino acids regulate mTORC1; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; COPII-mediated vesicle transport; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Postmitotic nuclear pore complex (NPC) reformation" "40" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9059271771169400119" "False" "High" "IsMasterProtein" "Q9UBK9" "Protein UXT OS=Homo sapiens OX=9606 GN=UXT PE=1 SV=1" "0.000" "False" "4.687" "5" "1" "2" "1" "157" "18.2" "7.59" "6.73" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02996" "8409" "ENSG00000126756" "UXT" "A0A0C4DFR8; B2R561; hsa:8409; Q5JZG3; Q9UBK9; Q9Y6E5" "" "Transcriptional Regulation by E2F6" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7058356130293402746" "False" "High" "IsMasterProtein" "Q6ZRS2" "Helicase SRCAP OS=Homo sapiens OX=9606 GN=SRCAP PE=1 SV=3" "0.000" "False" "4.684" "0" "1" "1" "1" "3230" "343.3" "5.96" "3.88" "1" "cell organization and biogenesis;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf07529" "10847" "ENSG00000080603" "SRCAP" "B0JZA6; hsa:10847; O15026; Q6ZRS2; Q7Z744; Q9Y5L9" "Pathways affected in adenoid cystic carcinoma" "" "1" "0" "1.132" "0.984" "1.576" "1.534" "1.374" "2.261" "2.424" "2.175" "2.309" "88.3" "100.0" "86.8" "139.2" "135.4" "121.3" "199.7" "214.0" "192.1" "203.9" "" "" "" "" "" "" "" "" "" "" "46.8" "55.4" "49.7" "64.1" "73.3" "67.5" "117.5" "116.8" "107.7" "203.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2746041825889845794" "False" "High" "IsMasterProtein" "Q15059" "Bromodomain-containing protein 3 OS=Homo sapiens OX=9606 GN=BRD3 PE=1 SV=1" "0.000" "False" "4.684" "3" "2" "2" "1" "726" "79.5" "9.36" "1.82" "2" "cell organization and biogenesis;other biological processes" "nucleus" "other molecular function" "Pf00439, Pf17035" "8019" "ENSG00000169925" "BRD3" "B1APD9; hsa:8019; Q15059; Q4G5Y3; Q5T1R7; Q8N5M3; Q92645" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3077097618423052072" "False" "High" "IsMasterProtein" "Q15032" "R3H domain-containing protein 1 OS=Homo sapiens OX=9606 GN=R3HDM1 PE=1 SV=3" "0.000" "False" "4.683" "2" "2" "2" "2" "1099" "120.6" "8.75" "4.38" "2" "" "" "" "Pf01424, Pf12752" "23518" "ENSG00000048991" "R3HDM1" "A8K1V0; B3KXQ9; E9PBB4; E9PG42; G5E9G8; hsa:23518; Q15032; Q8IW32" "" "" "0" "0" "1.143" "1.091" "1.137" "1.095" "1.127" "1.322" "1.414" "1.410" "1.100" "133.5" "152.6" "145.6" "151.7" "146.1" "150.4" "176.4" "188.7" "188.2" "146.8" "" "" "" "" "" "" "" "" "" "" "70.7" "84.6" "83.4" "69.9" "79.1" "83.6" "103.8" "103.0" "105.6" "146.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4795865386403905334" "False" "High" "IsMasterProtein" "Q9Y4Z0" "U6 snRNA-associated Sm-like protein LSm4 OS=Homo sapiens OX=9606 GN=LSM4 PE=1 SV=1" "0.000" "False" "4.671" "9" "1" "1" "1" "139" "15.3" "9.99" "3.50" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "25804" "ENSG00000130520" "LSM4" "hsa:25804; Q9Y4Z0" "Ciliary landscape" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "3" "0" "0.871" "1.062" "1.015" "0.992" "0.940" "0.974" "1.079" "1.389" "0.498" "201.9" "175.7" "214.5" "205.0" "200.3" "189.8" "196.7" "217.9" "280.5" "100.6" "" "" "" "" "" "" "" "" "" "" "106.9" "97.4" "122.8" "94.4" "108.4" "105.6" "115.7" "119.0" "157.3" "100.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6964625045538099576" "False" "High" "IsMasterProtein" "Q9H6R7" "WD repeat and coiled-coil-containing protein OS=Homo sapiens OX=9606 GN=WDCP PE=1 SV=1" "0.000" "False" "4.671" "2" "2" "3" "2" "721" "79.1" "6.70" "7.13" "2" "cell organization and biogenesis" "" "other molecular function" "Pf15390" "80304" "ENSG00000163026" "WDCP" "D6W532; hsa:80304; Q8IYK0; Q9H6R7; Q9HBP5" "Mesodermal commitment pathway" "Signaling by ALK fusions and activated point mutants" "2" "0" "1.010" "0.900" "1.136" "1.030" "0.995" "1.013" "1.193" "1.054" "1.426" "141.2" "142.6" "127.1" "160.5" "145.4" "140.6" "143.0" "168.5" "148.9" "201.4" "" "" "" "" "" "" "" "" "" "" "74.8" "79.1" "72.8" "73.9" "78.7" "78.2" "84.2" "92.0" "83.5" "201.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6769080269671987288" "False" "High" "IsMasterProtein" "Q9NVP1" "ATP-dependent RNA helicase DDX18 OS=Homo sapiens OX=9606 GN=DDX18 PE=1 SV=2" "0.000" "False" "4.662" "1" "1" "1" "1" "670" "75.4" "9.50" "3.24" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271, Pf13959" "8886" "ENSG00000088205" "DDX18" "hsa:8886; Q6GTZ9; Q6IAU4; Q92732; Q9BQB7; Q9NVP1" "" "" "0" "0" "0.898" "1.011" "0.999" "0.924" "0.824" "1.141" "1.192" "1.319" "1.503" "86.9" "78.0" "87.8" "86.8" "80.3" "71.6" "99.1" "103.6" "114.6" "130.6" "" "" "" "" "" "" "" "" "" "" "46.0" "43.2" "50.3" "40.0" "43.5" "39.8" "58.3" "56.5" "64.3" "130.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3530814954955127226" "False" "High" "IsMasterProtein" "Q9UKV0" "Histone deacetylase 9 OS=Homo sapiens OX=9606 GN=HDAC9 PE=1 SV=2" "0.000" "False" "4.661" "1" "2" "2" "2" "1011" "111.2" "6.89" "5.80" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00850, Pf12203" "9734" "ENSG00000048052" "HDAC9" "A7E2F3; B7Z4I4; B7Z917; B7Z928; B7Z940; C9JS87; E7EX34; F8W9E0; hsa:9734; O94845; O95028; Q2M2R6; Q86SL1; Q86US3; Q9UKV0" "MicroRNAs in cardiomyocyte hypertrophy; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; HDAC6 interactions in the central nervous system; Sudden infant death syndrome (SIDS) susceptibility pathways" "Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway" "12" "0" "0.989" "0.989" "1.002" "0.999" "0.988" "0.891" "0.826" "0.963" "1.972" "217.0" "214.7" "214.7" "217.5" "216.7" "214.4" "193.4" "179.2" "209.0" "428.1" "" "" "" "" "" "" "" "" "" "" "114.9" "119.0" "122.9" "100.2" "117.3" "119.3" "113.8" "97.8" "117.3" "428.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4785395366368004219" "False" "High" "IsMasterProtein" "Q15274" "Nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Homo sapiens OX=9606 GN=QPRT PE=1 SV=3" "0.000" "False" "4.657" "4" "1" "1" "1" "297" "30.8" "6.21" "2.75" "1" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01729, Pf02749" "23475" "ENSG00000103485" "QPRT" "hsa:23475; Q15274; Q53XW7; Q96G22; Q9BSG6" "NAD biosynthesis II (from tryptophan); NAD+ biosynthetic pathways; 16p11.2 proximal deletion syndrome; Kynurenine pathway and links to cell senescence" "Nicotinate metabolism" "5" "0" "0.899" "0.957" "0.894" "0.947" "0.851" "0.870" "0.908" "0.852" "0.750" "128.3" "115.3" "122.8" "114.6" "121.5" "109.1" "111.6" "116.5" "109.3" "96.2" "" "" "" "" "" "" "" "" "" "" "67.9" "63.9" "70.3" "52.8" "65.7" "60.7" "65.7" "63.6" "61.3" "96.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2544930509745837934" "False" "High" "IsMasterProtein" "P81877" "Single-stranded DNA-binding protein 2 OS=Homo sapiens OX=9606 GN=SSBP2 PE=1 SV=2" "0.000" "False" "4.654" "4" "1" "1" "1" "361" "37.8" "6.64" "3.77" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf04503" "23635" "ENSG00000145687" "SSBP2" "B2R5W1; B7Z1J2; B7Z2L9; B7Z665; D6RH18; E9PB74; E9PDA8; hsa:23635; P81877; Q8N2Q2; Q9BWW6; Q9Y4T7" "" "" "0" "0" "1.007" "0.806" "1.043" "0.752" "0.998" "0.919" "0.958" "1.078" "0.569" "50.4" "50.8" "40.7" "52.6" "37.9" "50.3" "46.3" "48.3" "54.4" "28.7" "" "" "" "" "" "" "" "" "" "" "26.7" "28.2" "23.3" "24.2" "20.5" "28.0" "27.3" "26.4" "30.5" "28.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2996634066211424368" "False" "High" "IsMasterProtein" "Q92994" "Transcription factor IIIB 90 kDa subunit OS=Homo sapiens OX=9606 GN=BRF1 PE=1 SV=1" "0.000" "False" "4.631" "2" "1" "1" "1" "677" "73.8" "5.43" "3.30" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00382, Pf07741, Pf08271" "2972" "ENSG00000185024" "BRF1" "B3KU36; B4DIG5; B7Z2N3; F5H5Z7; F8WA46; hsa:2972; Q13223; Q3SYD9; Q5PR24; Q6IQ02; Q92994; Q96KX3; Q9HCW6; Q9HCW7; Q9HCW8" "TAR syndrome" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "4" "0" "0.989" "1.005" "1.171" "1.728" "1.353" "1.389" "0.701" "0.974" "2.752" "16.1" "15.9" "16.1" "18.8" "27.7" "21.7" "22.3" "11.3" "15.6" "44.2" "" "" "" "" "" "" "" "" "" "" "8.5" "8.8" "9.2" "8.7" "15.0" "12.1" "13.1" "6.1" "8.8" "44.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6138498598484703965" "False" "High" "IsMasterProtein" "P30405" "Peptidyl-prolyl cis-trans isomerase F, mitochondrial OS=Homo sapiens OX=9606 GN=PPIF PE=1 SV=1" "0.000" "False" "4.630" "7" "2" "3" "1" "207" "22.0" "9.38" "8.89" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00160" "10105" "ENSG00000108179" "PPIF" "hsa:10105; P30405; Q2YDB7; Q5W131" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "" "2" "0" "0.929" "1.059" "0.869" "0.825" "0.857" "0.821" "0.786" "0.893" "0.793" "394.7" "366.7" "418.0" "343.0" "325.6" "338.5" "324.1" "310.1" "352.7" "312.8" "" "" "" "" "" "" "" "" "" "" "209.0" "203.3" "239.4" "157.9" "176.2" "188.3" "190.8" "169.3" "197.8" "312.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1301679656055029716" "False" "High" "IsMasterProtein" "Q9BWG6" "Sodium channel modifier 1 OS=Homo sapiens OX=9606 GN=SCNM1 PE=1 SV=1" "0.000" "False" "4.627" "8" "2" "2" "2" "230" "25.9" "8.87" "5.90" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf15803, Pf15805" "100534012; 79005" "ENSG00000163156" "SCNM1" "B4DWR1; hsa:100534012; hsa:79005; Q5JR74; Q9BWG6" "" "" "0" "0" "1.090" "1.062" "1.110" "1.061" "1.062" "1.063" "1.061" "0.987" "0.878" "231.0" "251.9" "245.2" "256.4" "245.2" "245.3" "245.6" "245.0" "227.9" "202.9" "" "" "" "" "" "" "" "" "" "" "122.3" "139.6" "140.4" "118.1" "132.6" "136.4" "144.6" "133.7" "127.8" "202.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7226470696601852520" "False" "High" "IsMasterProtein" "Q9H0A8" "COMM domain-containing protein 4 OS=Homo sapiens OX=9606 GN=COMMD4 PE=1 SV=1" "0.000" "False" "4.625" "8" "2" "2" "2" "199" "21.8" "7.31" "4.37" "2" "" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf07258, Pf21672" "54939" "ENSG00000140365" "COMMD4" "B2RBN4; H3BUL2; hsa:54939; Q7L637; Q9H0A8; Q9NX43" "" "Neddylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8244788051015200479" "False" "High" "IsMasterProtein" "O43447" "Peptidyl-prolyl cis-trans isomerase H OS=Homo sapiens OX=9606 GN=PPIH PE=1 SV=1" "0.000" "False" "4.623" "12" "3" "3" "2" "177" "19.2" "8.07" "4.03" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00160" "10465" "ENSG00000171960" "PPIH" "A6NNE7; hsa:10465; O43447" "" "mRNA Splicing - Major Pathway; SARS-CoV-1 activates/modulates innate immune responses" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7987145187797725947" "False" "High" "IsMasterProtein" "Q9H6R0" "ATP-dependent RNA helicase DHX33 OS=Homo sapiens OX=9606 GN=DHX33 PE=1 SV=2" "0.000" "False" "4.615" "2" "1" "1" "1" "707" "78.8" "8.91" "2.76" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "56919" "ENSG00000005100" "DHX33" "B4DHF9; hsa:56919; Q4G149; Q5CZ73; Q9H5M9; Q9H6R0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-728003267780759381" "False" "High" "IsMasterProtein" "Q8WV07" "Protein LTO1 homolog OS=Homo sapiens OX=9606 GN=LTO1 PE=1 SV=2" "0.000" "False" "4.611" "12" "2" "2" "2" "137" "15.3" "5.80" "2.94" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "nucleus" "" "Pf09811" "220064" "ENSG00000149716" "LTO1" "B2R4R2; hsa:220064; Q8NFK0; Q8WV07" "" "" "0" "0" "1.388" "1.224" "1.284" "1.142" "1.144" "1.182" "1.102" "0.945" "0.936" "142.6" "198.0" "174.7" "183.1" "162.9" "163.2" "168.7" "157.2" "134.7" "133.6" "" "" "" "" "" "" "" "" "" "" "75.5" "109.8" "100.0" "84.3" "88.2" "90.8" "99.3" "85.8" "75.6" "133.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8476150003951297336" "False" "High" "IsMasterProtein" "Q96KG9" "N-terminal kinase-like protein OS=Homo sapiens OX=9606 GN=SCYL1 PE=1 SV=1" "0.000" "False" "4.609" "2" "2" "2" "2" "808" "89.6" "6.30" "4.15" "2" "stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069" "57410" "ENSG00000142186" "SCYL1" "A6NJF1; hsa:57410; Q96G50; Q96KG8; Q96KG9; Q96KH1; Q9HAW5; Q9HBL3; Q9NR53" "" "" "0" "0" "1.078" "1.150" "1.322" "1.060" "0.830" "1.125" "0.808" "1.066" "1.942" "61.0" "65.8" "70.2" "80.7" "64.7" "50.6" "68.6" "49.3" "65.0" "118.5" "" "" "" "" "" "" "" "" "" "" "32.3" "36.5" "40.2" "37.1" "35.0" "28.1" "40.4" "26.9" "36.5" "118.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7473966995224482536" "False" "High" "IsMasterProtein" "Q13233" "Mitogen-activated protein kinase kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP3K1 PE=1 SV=4" "0.000" "False" "4.608" "1" "2" "2" "2" "1512" "164.4" "7.74" "1.99" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf04434, Pf21040" "4214" "ENSG00000095015" "MAP3K1" "hsa:4214; Q13233" "IL-1 signaling pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor pathway; Angiopoietin-like protein 8 regulatory pathway; BMP signaling in eyelid development; Oxidative damage response; PDGFR-beta pathway; p38 MAPK signaling pathway; MAPK cascade; EGF/EGFR signaling pathway; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Hepatitis B infection; Insulin signaling; MAP3K1 role in promoting and blocking gonadal determination; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Interferon type I signaling pathways; DNA damage response (only ATM dependent); Serotonin HTR1 group and FOS pathway" "MyD88:MAL(TIRAP) cascade initiated on plasma membrane; FCERI mediated MAPK activation; TRAF6 mediated NF-kB activation; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation; MyD88 cascade initiated on plasma membrane" "32" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6167412320153067815" "False" "High" "IsMasterProtein" "P35613" "Basigin OS=Homo sapiens OX=9606 GN=BSG PE=1 SV=2" "0.000" "False" "4.604" "4" "2" "2" "2" "385" "42.2" "5.66" "4.53" "2" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13927" "682" "ENSG00000172270" "BSG" "A6NJW1; D3YLG5; hsa:682; P35613; Q7Z796; Q8IZL7" "Matrix metalloproteinases; VEGFA-VEGFR2 signaling; IL-18 signaling pathway" "Degradation of the extracellular matrix; Integrin cell surface interactions; Pyruvate metabolism; Aspirin ADME; Basigin interactions; Proton-coupled monocarboxylate transport; Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)" "10" "0" "0.973" "1.036" "1.008" "0.884" "0.885" "1.052" "1.035" "0.972" "0.762" "334.1" "325.1" "346.1" "336.8" "295.5" "295.8" "351.6" "345.8" "324.8" "254.7" "" "" "" "" "" "" "" "" "" "" "176.9" "180.3" "198.2" "155.1" "159.9" "164.5" "206.9" "188.7" "182.2" "254.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3933155493213774730" "False" "High" "IsMasterProtein" "Cont_Q3SZV7" "Hemopexin OS=Bos taurus OX=9913 GN=HPX PE=2 SV=1" "0.000" "True" "4.597" "4" "2" "2" "2" "459" "52.2" "7.80" "5.33" "2" "other metabolic processes;transport;other biological processes" "non-structural extracellular" "transporter activity;other molecular function" "Pf00045" "534509" "ENSBIXG00000017851" "HPX" "A0A4W2EKG5; bta:534509; Q3SZV7" "" "" "0" "0" "1.067" "1.002" "1.118" "1.383" "1.305" "1.052" "1.276" "1.354" "0.668" "181.0" "193.1" "181.5" "202.3" "250.4" "236.3" "190.5" "231.0" "245.1" "121.0" "" "" "" "" "" "" "" "" "" "" "95.9" "107.1" "103.9" "93.2" "135.5" "131.4" "112.1" "126.1" "137.5" "121.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8564322409184755345" "False" "High" "IsMasterProtein" "Q9Y4K3" "TNF receptor-associated factor 6 OS=Homo sapiens OX=9606 GN=TRAF6 PE=1 SV=1" "0.000" "False" "4.596" "4" "2" "2" "2" "522" "59.5" "6.44" "2.79" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02176, Pf13923, Pf18048, Pf21355" "7189" "ENSG00000175104" "TRAF6" "A6NKI7; A8KAB3; D3DR16; hsa:7189; Q8NEH5; Q9Y4K3" "IL-1 signaling pathway; RANKL/RANK signaling pathway; IL-17 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Melatonin metabolism and effects; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced NF-kB survival signaling; Interleukin-1 induced activation of NF-kB; TGF-beta signaling pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; MYD88 distinct input-output pathway; ApoE and miR-146 in inflammation and atherosclerosis; Oxidative damage response; Fibrin complement receptor 3 signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; miRNA role in immune response in sepsis; LTF danger signal response pathway; Signal transduction through IL1R; Interactions between immune cells and microRNAs in tumor microenvironment; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; 16p11.2 proximal deletion syndrome; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Modulators of TCR signaling and T cell activation; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction; Clock-controlled autophagy in bone metabolism; Induction of autophagy and toll-like receptor signaling pathways by graphene oxide ; T-cell receptor signaling pathway; Toll-like receptor signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; SARS-CoV-2 activates/modulates innate and adaptive immune responses; PIP3 activates AKT signaling; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; TRAF6 mediated NF-kB activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; SARS-CoV-1 activates/modulates innate immune responses; Alpha-protein kinase 1 signaling pathway; Ovarian tumor domain proteases; TRAF6 mediated IRF7 activation; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "78" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4939366548436887845" "False" "High" "IsMasterProtein" "Q7L0Y3" "tRNA methyltransferase 10 homolog C OS=Homo sapiens OX=9606 GN=TRMT10C PE=1 SV=2" "0.000" "False" "4.592" "2" "1" "1" "1" "403" "47.3" "9.36" "3.75" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01746" "54931" "ENSG00000174173" "TRMT10C" "hsa:54931; Q7L0Y3; Q9NRG5; Q9NX54; Q9Y596" "" "tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion" "3" "0" "0.994" "1.016" "1.036" "0.964" "0.985" "0.834" "0.728" "0.847" "2.473" "149.3" "148.4" "151.8" "154.6" "144.0" "147.0" "124.5" "108.7" "126.5" "369.2" "" "" "" "" "" "" "" "" "" "" "79.1" "82.3" "86.9" "71.2" "77.9" "81.8" "73.2" "59.3" "70.9" "369.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5046480723636324863" "False" "High" "IsMasterProtein" "Q9Y314" "Nitric oxide synthase-interacting protein OS=Homo sapiens OX=9606 GN=NOSIP PE=1 SV=1" "0.000" "False" "4.588" "4" "1" "1" "1" "301" "33.2" "8.82" "3.50" "1" "other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf15906" "51070" "ENSG00000142546" "NOSIP" "Q96FD2; Q9Y314" "" "NOSIP mediated eNOS trafficking" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "Not Found" "High" "High" "1" "" "-331948696601358906" "False" "High" "IsMasterProtein" "Q969T7" "7-methylguanosine phosphate-specific 5'-nucleotidase OS=Homo sapiens OX=9606 GN=NT5C3B PE=1 SV=4" "0.000" "False" "4.586" "3" "1" "2" "1" "300" "34.4" "6.38" "5.67" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf05822" "115024" "ENSG00000141698" "NT5C3B" "A8MWB9; C9JKC4; hsa:115024; Q7L3B7; Q969T7" "" "mRNA decay by 3' to 5' exoribonuclease" "1" "0" "1.366" "1.395" "1.390" "1.213" "1.213" "1.337" "1.041" "1.323" "1.981" "75.1" "102.5" "104.7" "104.4" "91.0" "91.1" "100.4" "78.2" "99.3" "148.7" "" "" "" "" "" "" "" "" "" "" "39.7" "56.8" "60.0" "48.1" "49.2" "50.7" "59.1" "42.7" "55.7" "148.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1197629715335020775" "False" "High" "IsMasterProtein" "Q02535" "DNA-binding protein inhibitor ID-3 OS=Homo sapiens OX=9606 GN=ID3 PE=1 SV=2" "0.000" "False" "4.582" "10" "1" "1" "1" "119" "13.0" "5.83" "3.23" "1" "developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00010" "3399" "ENSG00000117318; ENSG00000283060" "ID3" "A8K1T8; hsa:3399; O75641; Q02535" "Adipogenesis; Orexin receptor pathway; ID signaling pathway" "NGF-stimulated transcription" "4" "0" "0.941" "0.755" "1.074" "1.038" "0.804" "0.899" "0.559" "0.607" "3.355" "63.9" "60.2" "48.3" "68.7" "66.4" "51.4" "57.5" "35.7" "38.8" "214.5" "" "" "" "" "" "" "" "" "" "" "33.9" "33.4" "27.6" "31.6" "35.9" "28.6" "33.8" "19.5" "21.8" "214.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5826180734752496445" "False" "High" "IsMasterProtein" "Q8N0X7" "Spartin OS=Homo sapiens OX=9606 GN=SPART PE=1 SV=1" "0.000" "False" "4.580" "2" "1" "1" "1" "666" "72.8" "5.91" "2.82" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf06911" "23111" "ENSG00000133104" "SPART" "hsa:23111; O60349; Q86Y67; Q8N0X7; Q9H1T2; Q9H1T3" "" "" "0" "0" "0.864" "1.062" "1.327" "1.174" "0.939" "1.214" "1.582" "1.344" "0.587" "47.2" "40.8" "50.1" "62.6" "55.3" "44.3" "57.3" "74.6" "63.4" "27.7" "" "" "" "" "" "" "" "" "" "" "25.0" "22.6" "28.7" "28.8" "29.9" "24.6" "33.7" "40.7" "35.6" "27.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2115401272640635068" "False" "High" "IsMasterProtein" "P41226" "Ubiquitin-like modifier-activating enzyme 7 OS=Homo sapiens OX=9606 GN=UBA7 PE=1 SV=2" "0.000" "False" "4.578" "2" "2" "2" "2" "1012" "111.6" "6.04" "4.65" "2" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf00899, Pf09358, Pf10585, Pf16190, Pf16191" "7318" "ENSG00000182179" "UBA7" "hsa:7318; P41226; Q9BRB2" "Proteasome degradation; Parkinson's disease pathway" "Termination of translesion DNA synthesis; Antigen processing: Ubiquitination & Proteasome degradation; ISG15 antiviral mechanism; Negative regulators of DDX58/IFIH1 signaling" "7" "0" "1.060" "1.028" "1.230" "1.235" "1.047" "1.109" "0.985" "1.155" "1.965" "205.9" "218.2" "211.7" "253.2" "254.4" "215.6" "228.3" "202.8" "237.9" "404.6" "" "" "" "" "" "" "" "" "" "" "109.0" "121.0" "121.2" "116.6" "137.6" "119.9" "134.3" "110.7" "133.4" "404.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8251896987743937176" "False" "High" "IsMasterProtein" "P53680" "AP-2 complex subunit sigma OS=Homo sapiens OX=9606 GN=AP2S1 PE=1 SV=2" "0.000" "False" "4.578" "12" "2" "3" "2" "142" "17.0" "6.18" "3.28" "2" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01217" "1175" "ENSG00000042753" "AP2S1" "B2R4Z4; hsa:1175; O75977; P53680; Q6PK67" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome" "MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; Potential therapeutics for SARS; Recycling pathway of L1; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "18" "0" "1.585" "1.294" "1.403" "1.325" "1.330" "1.644" "1.538" "1.349" "1.157" "62.2" "98.6" "80.5" "87.3" "82.4" "82.8" "102.3" "95.7" "83.9" "72.0" "" "" "" "" "" "" "" "" "" "" "32.9" "54.7" "46.1" "40.2" "44.6" "46.0" "60.2" "52.2" "47.1" "72.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8993746763041335004" "False" "High" "IsMasterProtein" "Q69YQ0" "Cytospin-A OS=Homo sapiens OX=9606 GN=SPECC1L PE=1 SV=3" "0.000" "False" "4.570" "1" "2" "2" "1" "1117" "124.5" "5.76" "5.58" "2" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "Pf00307" "23384" "ENSG00000100014" "SPECC1L" "B7Z758; F5H1H6; hsa:23384; O15081; Q69YQ0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-781411655815037660" "False" "High" "IsMasterProtein" "P14316" "Interferon regulatory factor 2 OS=Homo sapiens OX=9606 GN=IRF2 PE=1 SV=2" "0.000" "False" "4.566" "4" "2" "3" "2" "349" "39.3" "7.52" "5.88" "2" "cell cycle OR cell proliferation;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605" "3660" "ENSG00000168310" "IRF2" "D6RCK5; H0Y8S3; hsa:3660; P14316; Q6IAS7; Q96B99" "Apoptosis; Rubinstein-Taybi syndrome 1; Type II interferon signaling" "Interferon gamma signaling; Factors involved in megakaryocyte development and platelet production; Interferon alpha/beta signaling; Pyroptosis" "7" "0" "0.987" "1.131" "1.195" "1.025" "1.056" "1.270" "1.433" "1.306" "1.147" "167.6" "165.3" "189.6" "200.3" "171.7" "176.9" "212.8" "240.1" "218.9" "192.3" "" "" "" "" "" "" "" "" "" "" "88.7" "91.7" "108.6" "92.2" "92.9" "98.4" "125.2" "131.1" "122.8" "192.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6257643935121491465" "False" "High" "IsMasterProtein" "Q15120" "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial OS=Homo sapiens OX=9606 GN=PDK3 PE=1 SV=1" "0.000" "False" "4.563" "4" "2" "2" "2" "406" "46.9" "8.37" "2.60" "2" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "mitochondrion;nucleus" "kinase activity;other molecular function" "Pf02518, Pf10436" "5165" "ENSG00000067992" "PDK3" "B4DXG6; hsa:5165; Q15120" "" "Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "2" "0" "1.108" "1.097" "1.508" "1.032" "1.129" "1.042" "1.051" "1.002" "0.871" "49.2" "54.5" "53.9" "74.1" "50.7" "55.5" "51.2" "51.7" "49.3" "42.8" "" "" "" "" "" "" "" "" "" "" "26.0" "30.2" "30.9" "34.1" "27.5" "30.9" "30.2" "28.2" "27.6" "42.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7938684201688622214" "False" "High" "IsMasterProtein" "Q8NC96" "Adaptin ear-binding coat-associated protein 1 OS=Homo sapiens OX=9606 GN=NECAP1 PE=1 SV=2" "0.000" "False" "4.560" "6" "2" "3" "2" "275" "29.7" "6.80" "5.06" "2" "transport" "other membranes;cytosol" "" "Pf07933" "25977" "ENSG00000089818" "NECAP1" "hsa:25977; Q2NL73; Q5XG95; Q6NWY6; Q8N153; Q8NC96; Q8NCB0; Q9BU52; Q9Y407" "" "Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis" "3" "0" "0.833" "0.867" "0.894" "1.056" "0.925" "0.866" "0.834" "0.933" "0.716" "287.4" "239.3" "249.2" "256.9" "303.5" "265.8" "248.8" "239.8" "268.0" "205.7" "" "" "" "" "" "" "" "" "" "" "152.2" "132.7" "142.7" "118.3" "164.2" "147.9" "146.4" "130.9" "150.3" "205.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2780012699029809096" "False" "High" "IsMasterProtein" "Q9H9J2" "Large ribosomal subunit protein mL44 OS=Homo sapiens OX=9606 GN=MRPL44 PE=1 SV=1" "0.000" "False" "4.559" "5" "2" "2" "2" "332" "37.5" "8.40" "5.55" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;mitochondrion;translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "" "65080" "ENSG00000135900" "MRPL44" "hsa:65080; Q53S16; Q6IA62; Q9H821; Q9H9J2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-268059577032989138" "False" "High" "IsMasterProtein" "Q9NVJ2" "ADP-ribosylation factor-like protein 8B OS=Homo sapiens OX=9606 GN=ARL8B PE=1 SV=1" "0.000" "False" "4.557" "5" "1" "1" "1" "186" "21.5" "8.43" "3.34" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00025" "55207" "ENSG00000134108" "ARL8B" "B4DI85; hsa:55207; Q9NVJ2" "Ciliary landscape" "" "1" "0" "1.003" "0.971" "0.889" "1.042" "1.086" "0.960" "0.989" "0.957" "0.703" "180.0" "180.6" "174.7" "160.0" "187.6" "195.5" "172.8" "178.0" "172.3" "126.5" "" "" "" "" "" "" "" "" "" "" "95.3" "100.1" "100.1" "73.7" "101.5" "108.8" "101.7" "97.2" "96.7" "126.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7224643183628006691" "False" "High" "IsMasterProtein" "O00303" "Eukaryotic translation initiation factor 3 subunit F OS=Homo sapiens OX=9606 GN=EIF3F PE=1 SV=1" "0.000" "False" "4.552" "5" "2" "2" "2" "357" "37.5" "5.45" "1.83" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01398, Pf13012" "8665" "ENSG00000175390" "EIF3F" "A8K0S2; hsa:8665; O00303; Q6IB45; Q8N978" "Translation factors; VEGFA-VEGFR2 signaling; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6714422319878504399" "False" "High" "IsMasterProtein" "O95391" "Pre-mRNA-splicing factor SLU7 OS=Homo sapiens OX=9606 GN=SLU7 PE=1 SV=2" "0.000" "False" "4.545" "2" "2" "2" "2" "586" "68.3" "7.14" "6.31" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11708" "10569" "ENSG00000164609" "SLU7" "D3DQK2; hsa:10569; O95391; Q3LUJ0; Q3LUJ1; Q6RXQ5; Q96FM9" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway" "4" "0" "1.085" "1.062" "1.446" "1.270" "1.206" "2.473" "2.633" "2.491" "1.857" "307.2" "333.5" "326.3" "444.4" "390.3" "370.4" "759.9" "809.1" "765.3" "570.6" "" "" "" "" "" "" "" "" "" "" "162.7" "184.9" "186.9" "204.6" "211.1" "206.0" "447.2" "441.6" "429.3" "570.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8849242953917426165" "False" "High" "IsMasterProtein" "Q9HCD5" "Nuclear receptor coactivator 5 OS=Homo sapiens OX=9606 GN=NCOA5 PE=1 SV=2" "0.000" "False" "4.536" "3" "2" "2" "2" "579" "65.5" "9.60" "4.94" "2" "signal transduction;other biological processes" "cytoskeleton;nucleus" "other molecular function" "" "57727" "ENSG00000124160" "NCOA5" "B2RTV9; E1P5R0; Q6HA99; Q9H1F2; Q9H2T2; Q9H4Y9; Q9HCD5" "" "" "0" "0" "0.993" "0.936" "1.420" "1.372" "1.134" "1.857" "1.866" "1.962" "1.078" "69.2" "68.8" "64.8" "98.3" "95.0" "78.5" "128.5" "129.2" "135.8" "74.6" "" "" "" "" "" "" "" "" "" "" "36.7" "38.1" "37.1" "45.3" "51.4" "43.7" "75.6" "70.5" "76.2" "74.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1907773996049463670" "False" "High" "IsMasterProtein" "O43504" "Ragulator complex protein LAMTOR5 OS=Homo sapiens OX=9606 GN=LAMTOR5 PE=1 SV=1" "0.000" "False" "4.532" "11" "1" "1" "1" "91" "9.6" "4.87" "3.71" "1" "cell organization and biogenesis;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf16672" "10542" "ENSG00000134248" "LAMTOR5" "A0A0C4DGV4; hsa:10542; O43504; Q6IBD8" "" "mTORC1-mediated signalling; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "7" "0" "1.007" "1.223" "1.101" "1.052" "0.948" "1.139" "0.958" "0.895" "0.628" "97.5" "98.2" "119.3" "107.4" "102.6" "92.5" "111.1" "93.4" "87.3" "61.2" "" "" "" "" "" "" "" "" "" "" "51.6" "54.4" "68.3" "49.5" "55.5" "51.5" "65.4" "51.0" "49.0" "61.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6827069170954705052" "False" "High" "IsMasterProtein" "Q9UKJ3" "G patch domain-containing protein 8 OS=Homo sapiens OX=9606 GN=GPATCH8 PE=1 SV=2" "0.000" "False" "4.531" "1" "2" "3" "2" "1502" "164.1" "8.66" "8.36" "2" "" "nucleus" "other molecular function" "Pf01585" "23131" "ENSG00000186566" "GPATCH8" "B9EGP9; hsa:23131; O60300; Q8TB99; Q9UKJ3" "" "" "0" "0" "0.961" "0.981" "1.013" "1.028" "0.937" "1.129" "1.010" "1.039" "0.883" "359.0" "344.9" "352.1" "363.6" "369.0" "336.5" "405.4" "362.5" "373.1" "316.9" "" "" "" "" "" "" "" "" "" "" "190.1" "191.2" "201.7" "167.5" "199.7" "187.2" "238.6" "197.8" "209.3" "316.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9119183533352449248" "False" "High" "IsMasterProtein" "Q9P0P8" "Mitochondrial transcription rescue factor 1 OS=Homo sapiens OX=9606 GN=MTRES1 PE=1 SV=1" "0.000" "False" "4.521" "6" "2" "2" "2" "240" "27.9" "9.29" "5.71" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "translation activity;nucleic acid binding activity" "" "51250" "ENSG00000130349" "MTRES1" "B3KRG9; hsa:51250; Q9P0P8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7421726054682487966" "False" "High" "IsMasterProtein" "Q9NX18" "Succinate dehydrogenase assembly factor 2, mitochondrial OS=Homo sapiens OX=9606 GN=SDHAF2 PE=1 SV=1" "0.000" "False" "4.516" "11" "2" "2" "2" "166" "19.6" "6.80" "2.52" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus" "" "Pf03937" "54949" "ENSG00000167985" "SDHAF2" "hsa:54949; Q9NX18" "Mitochondrial complex II assembly" "" "1" "0" "1.033" "0.928" "1.010" "0.880" "0.848" "1.035" "0.973" "1.021" "0.506" "156.8" "162.0" "145.5" "158.4" "138.1" "132.9" "162.3" "152.5" "160.2" "79.4" "" "" "" "" "" "" "" "" "" "" "83.0" "89.8" "83.3" "73.0" "74.7" "73.9" "95.5" "83.3" "89.8" "79.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6354667477089484627" "False" "High" "IsMasterProtein" "Q5T2E6" "Armadillo-like helical domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ARMH3 PE=1 SV=1" "0.000" "False" "4.505" "3" "2" "2" "2" "689" "78.7" "6.60" "4.66" "2" "other biological processes" "other membranes;cytosol;ER/Golgi" "" "Pf08427" "79591" "ENSG00000120029" "ARMH3" "hsa:79591; Q2TB87; Q5T2E6; Q9H8Z9" "" "" "0" "0" "1.231" "1.189" "1.070" "1.297" "1.179" "1.090" "1.445" "1.213" "0.894" "55.0" "67.7" "65.4" "58.8" "71.3" "64.8" "59.9" "79.5" "66.7" "49.2" "" "" "" "" "" "" "" "" "" "" "29.1" "37.5" "37.4" "27.1" "38.6" "36.0" "35.3" "43.4" "37.4" "49.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4934809763916306973" "False" "High" "IsMasterProtein" "Q6ZS81" "WD repeat- and FYVE domain-containing protein 4 OS=Homo sapiens OX=9606 GN=WDFY4 PE=1 SV=3" "0.000" "False" "4.503" "0" "1" "1" "1" "3184" "353.4" "6.32" "2.42" "1" "other metabolic processes;other biological processes" "ER/Golgi;other cytoplasmic organelle" "" "Pf00400, Pf02138" "57705" "ENSG00000128815" "WDFY4" "B9ZVP2; hsa:57705; Q6ZS81; Q86WZ4; Q8N4A3; Q8TEN7; Q96BE1; Q9H7H8; Q9HCG5" "10q11.21q11.23 copy number variation syndrome" "" "1" "0" "0.955" "1.338" "1.208" "1.310" "0.983" "1.230" "0.802" "0.993" "3.006" "29.9" "28.6" "40.0" "36.1" "39.2" "29.4" "36.8" "24.0" "29.7" "89.9" "" "" "" "" "" "" "" "" "" "" "15.8" "15.8" "22.9" "16.6" "21.2" "16.3" "21.6" "13.1" "16.7" "89.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2858962051142088186" "False" "High" "IsMasterProtein" "Q8WXE1" "ATR-interacting protein OS=Homo sapiens OX=9606 GN=ATRIP PE=1 SV=1" "0.000" "False" "4.501" "3" "2" "3" "2" "791" "85.8" "6.32" "1.84" "2" "DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "other molecular function" "" "84126" "ENSG00000164053" "ATRIP" "A8K6A3; A8K714; B2RCE7; B4DU92; B5MEB7; hsa:84126; Q69YK9; Q8NHQ2; Q8WUG7; Q8WXE1; Q96CL3; Q9HA30" "miRNA regulation of DNA damage response; ATR signaling; DNA damage response" "Fanconi Anemia Pathway; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "11" "0" "1.073" "0.939" "1.180" "1.064" "0.945" "0.984" "0.932" "0.859" "0.748" "74.9" "80.3" "70.3" "88.3" "79.6" "70.8" "73.7" "69.7" "64.3" "56.0" "" "" "" "" "" "" "" "" "" "" "39.6" "44.5" "40.3" "40.7" "43.1" "39.4" "43.4" "38.1" "36.0" "56.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8104731299280243918" "False" "High" "IsMasterProtein" "Q4G148" "Glucoside xylosyltransferase 1 OS=Homo sapiens OX=9606 GN=GXYLT1 PE=1 SV=2" "0.000" "False" "4.499" "5" "2" "2" "2" "440" "50.5" "8.65" "4.57" "2" "protein metabolism;other metabolic processes" "other membranes" "other molecular function" "Pf01501" "283464" "ENSG00000151233" "GXYLT1" "B3KWJ2; hsa:283464; Q4G148; Q8IXV1; Q96BH4" "" "" "0" "0" "1.080" "1.028" "1.175" "1.113" "1.064" "1.205" "1.228" "1.092" "1.032" "123.4" "133.3" "126.9" "145.0" "137.3" "131.3" "148.7" "151.6" "134.8" "127.3" "" "" "" "" "" "" "" "" "" "" "65.3" "73.9" "72.7" "66.8" "74.3" "73.0" "87.5" "82.7" "75.6" "127.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6438294564185077030" "False" "High" "IsMasterProtein" "Q9BPW8" "Protein NipSnap homolog 1 OS=Homo sapiens OX=9606 GN=NIPSNAP1 PE=1 SV=1" "0.000" "False" "4.492" "5" "2" "3" "1" "284" "33.3" "9.31" "8.84" "2" "other biological processes" "plasma membrane;other membranes;mitochondrion" "" "Pf07978" "8508" "ENSG00000184117" "NIPSNAP1" "B2RAY3; hsa:8508; O43800; Q9BPW8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "592112739915171791" "False" "High" "IsMasterProtein" "Q8NCG7" "Diacylglycerol lipase-beta OS=Homo sapiens OX=9606 GN=DAGLB PE=1 SV=2" "0.000" "False" "4.490" "2" "1" "1" "1" "672" "73.7" "6.55" "3.00" "1" "cell cycle OR cell proliferation;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus" "other molecular function" "Pf01764" "221955" "ENSG00000164535" "DAGLB" "A4D2P3; B3KV90; B4DQU0; hsa:221955; Q6PIX3; Q8N2N2; Q8N9S1; Q8NCG7; Q8TED3; Q8WXE6" "Cannabinoid receptor signaling; ADHD and autism (ASD) linked metabolic pathways and SNP" "Arachidonate production from DAG" "3" "0" "1.106" "1.143" "1.126" "0.998" "1.020" "1.016" "1.087" "1.147" "0.944" "113.6" "125.6" "129.8" "127.9" "113.4" "115.9" "115.4" "123.4" "130.3" "107.2" "" "" "" "" "" "" "" "" "" "" "60.1" "69.6" "74.3" "58.9" "61.4" "64.5" "67.9" "67.4" "73.1" "107.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9154000995379348407" "False" "High" "IsMasterProtein" "Q16644" "MAP kinase-activated protein kinase 3 OS=Homo sapiens OX=9606 GN=MAPKAPK3 PE=1 SV=1" "0.000" "False" "4.490" "6" "2" "2" "1" "382" "43.0" "7.28" "3.72" "2" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "7867" "ENSG00000114738" "MAPKAPK3" "B5BU67; hsa:7867; Q16644" "Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; Serotonin HTR1 group and FOS pathway" "Oxidative Stress Induced Senescence; VEGFA-VEGFR2 Pathway; p38MAPK events; activated TAK1 mediates p38 MAPK activation" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7551679411334968012" "False" "High" "IsMasterProtein" "Q15649" "Zinc finger HIT domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZNHIT3 PE=1 SV=2" "0.000" "False" "4.489" "6" "1" "1" "1" "155" "17.6" "5.67" "3.73" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04438, Pf21373" "9326" "ENSG00000273611; ENSG00000278574" "ZNHIT3" "A8K493; hsa:9326; K7EQP1; Q15649; Q8WVJ3" "17q12 copy number variation syndrome" "" "1" "0" "1.063" "1.103" "1.148" "1.182" "1.046" "1.111" "1.181" "1.158" "0.688" "191.6" "203.7" "211.3" "220.0" "226.5" "200.6" "212.9" "226.3" "222.0" "131.8" "" "" "" "" "" "" "" "" "" "" "101.5" "112.9" "121.0" "101.3" "122.6" "111.6" "125.3" "123.5" "124.5" "131.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2093622632730469128" "False" "High" "IsMasterProtein" "Q15418" "Ribosomal protein S6 kinase alpha-1 OS=Homo sapiens OX=9606 GN=RPS6KA1 PE=1 SV=2" "0.000" "False" "4.488" "2" "2" "2" "1" "735" "82.7" "7.83" "5.00" "2" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00433" "6195" "ENSG00000117676; ENSG00000281877" "RPS6KA1" "A6NGG4; A8K9K7; B2RDY8; B7Z5J0; E9PRI4; hsa:6195; Q15418; Q5SVM5; Q5SVM8; Q5SVM9; Q96C05; Q9BQK2" "IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; BDNF-TrkB signaling; Angiopoietin-like protein 8 regulatory pathway; TYROBP causal network in microglia; Thermogenesis; EGF/EGFR signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Cytoplasmic ribosomal proteins; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Hippocampal synaptogenesis and neurogenesis; Macrophage-stimulating protein (MSP) signaling network map" "Senescence-Associated Secretory Phenotype (SASP); Recycling pathway of L1; RSK activation; ERK/MAPK targets; CREB phosphorylation; Gastrin-CREB signalling pathway via PKC and MAPK" "26" "0" "0.860" "0.786" "0.867" "0.861" "1.015" "0.789" "0.676" "0.891" "2.349" "82.4" "70.8" "64.8" "71.4" "70.9" "83.7" "65.0" "55.7" "73.4" "193.6" "" "" "" "" "" "" "" "" "" "" "43.6" "39.3" "37.1" "32.9" "38.4" "46.5" "38.3" "30.4" "41.2" "193.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7588852199291352544" "False" "High" "IsMasterProtein" "Q68D06" "Schlafen family member 13 OS=Homo sapiens OX=9606 GN=SLFN13 PE=1 SV=1" "0.000" "False" "4.486" "2" "2" "2" "1" "897" "102.0" "6.96" "4.86" "2" "RNA metabolism OR transcription;other metabolic processes;stress response" "other cell component" "nucleic acid binding activity;other molecular function" "Pf04326, Pf09848, Pf17057, Pf21026" "146857" "ENSG00000154760" "SLFN13" "E1P645; hsa:146857; Q658M1; Q68D06; Q6ZS51; Q96A81" "17q12 copy number variation syndrome" "" "1" "1" "1.108" "1.187" "1.091" "1.031" "1.152" "1.127" "1.056" "1.020" "1.296" "146.7" "162.5" "174.2" "160.1" "151.3" "169.1" "165.3" "154.8" "149.6" "190.1" "" "" "" "" "" "" "" "" "" "" "77.7" "90.1" "99.7" "73.7" "81.9" "94.0" "97.3" "84.5" "83.9" "190.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2748783261369810529" "False" "High" "IsMasterProtein" "P11182" "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DBT PE=1 SV=4" "0.000" "False" "4.485" "2" "1" "2" "1" "482" "53.5" "8.51" "5.67" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "0.909" "0.873" "0.909" "0.922" "0.829" "0.902" "0.852" "0.917" "0.520" "272.4" "247.6" "237.9" "247.6" "251.2" "225.9" "245.7" "232.0" "249.7" "141.6" "" "" "" "" "" "" "" "" "" "" "144.2" "137.3" "136.2" "114.0" "135.9" "125.6" "144.6" "126.6" "140.1" "141.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8624164927491725104" "False" "High" "IsMasterProtein" "O75449" "Katanin p60 ATPase-containing subunit A1 OS=Homo sapiens OX=9606 GN=KATNA1 PE=1 SV=1" "0.000" "False" "4.482" "3" "2" "3" "2" "491" "55.9" "6.90" "7.81" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00004, Pf09336, Pf17862, Pf21126" "11104" "ENSG00000186625" "KATNA1" "E1P5A3; hsa:11104; O75449; Q5TFA8; Q5TFA9; Q86VN2; Q9NU52" "" "" "0" "0" "0.983" "0.979" "1.000" "1.007" "1.175" "0.962" "0.723" "1.094" "2.711" "313.4" "308.0" "306.9" "313.5" "315.6" "368.4" "301.6" "226.6" "342.9" "849.6" "" "" "" "" "" "" "" "" "" "" "166.0" "170.8" "175.8" "144.4" "170.8" "204.9" "177.5" "123.7" "192.4" "849.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8551300482488071361" "False" "High" "IsMasterProtein" "P78332" "RNA-binding protein 6 OS=Homo sapiens OX=9606 GN=RBM6 PE=1 SV=5" "0.000" "False" "4.473" "2" "2" "2" "2" "1123" "128.6" "6.32" "2.54" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf01585, Pf17780" "10180" "ENSG00000004534" "RBM6" "B4E0G6; hsa:10180; O60549; O75524; P78332; Q86SS3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3269838763012707348" "False" "High" "IsMasterProtein" "P0C7P4" "Putative cytochrome b-c1 complex subunit Rieske-like protein 1 OS=Homo sapiens OX=9606 GN=UQCRFS1P1 PE=5 SV=1" "0.000" "False" "4.472" "6" "2" "2" "2" "283" "30.8" "8.87" "5.04" "2" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00355, Pf02921, Pf09165" "" "" "UQCRFS1P1" "P0C7P4" "" "" "0" "0" "1.091" "1.130" "1.082" "1.073" "1.048" "1.016" "0.987" "0.986" "1.288" "460.0" "501.7" "519.8" "497.6" "493.6" "482.3" "467.2" "454.1" "453.3" "592.3" "" "" "" "" "" "" "" "" "" "" "243.5" "278.1" "297.7" "229.2" "267.0" "268.3" "275.0" "247.9" "254.3" "592.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2247702318764912013" "False" "High" "IsMasterProtein" "Q8NI22" "Multiple coagulation factor deficiency protein 2 OS=Homo sapiens OX=9606 GN=MCFD2 PE=1 SV=1" "0.000" "False" "4.469" "9" "1" "2" "1" "146" "16.4" "4.63" "6.05" "1" "transport" "other membranes;ER/Golgi" "other molecular function" "Pf13499" "90411" "ENSG00000180398" "MCFD2" "A8K7W2; D6W5A9; E9PD95; hsa:90411; Q53SS3; Q68D61; Q8N3M5; Q8NI22" "" "COPII-mediated vesicle transport; Cargo concentration in the ER; Transport to the Golgi and subsequent modification" "3" "0" "0.860" "1.183" "0.992" "1.044" "1.064" "0.999" "1.087" "1.346" "0.882" "131.0" "112.7" "155.0" "130.0" "136.8" "139.5" "130.9" "142.4" "176.4" "115.5" "" "" "" "" "" "" "" "" "" "" "69.4" "62.5" "88.8" "59.9" "74.0" "77.6" "77.0" "77.8" "98.9" "115.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-355239685975103350" "False" "High" "IsMasterProtein" "O14578" "Citron Rho-interacting kinase OS=Homo sapiens OX=9606 GN=CIT PE=1 SV=2" "0.000" "False" "4.469" "1" "2" "2" "2" "2027" "231.3" "6.57" "4.96" "2" "cell cycle OR cell proliferation;other metabolic processes;developmental processes;other biological processes" "cytosol" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00169, Pf00433, Pf00780" "11113" "ENSG00000122966" "CIT" "hsa:11113; O14578; Q2M5E1; Q6XUH8; Q86UQ9; Q9UPZ7" "Pleural mesothelioma; G13 signaling pathway" "RHOC GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; RHO GTPases activate CIT" "7" "0" "1.163" "1.052" "1.232" "1.304" "1.297" "1.196" "0.979" "1.314" "2.514" "164.4" "191.2" "173.0" "202.6" "214.3" "213.1" "196.5" "160.9" "216.0" "413.2" "" "" "" "" "" "" "" "" "" "" "87.0" "106.0" "99.1" "93.3" "116.0" "118.5" "115.7" "87.8" "121.2" "413.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5255338936326354588" "False" "High" "IsMasterProtein" "O75448" "Mediator of RNA polymerase II transcription subunit 24 OS=Homo sapiens OX=9606 GN=MED24 PE=1 SV=1" "0.000" "False" "4.462" "1" "1" "1" "1" "989" "110.2" "6.95" "3.22" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf11277" "9862" "ENSG00000008838" "MED24" "A8K4S5; B3KMR9; hsa:9862; O75448; Q14143; Q9NNY5" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1124967282390941354" "False" "High" "IsMasterProtein" "Q9HB90" "Ras-related GTP-binding protein C OS=Homo sapiens OX=9606 GN=RRAGC PE=1 SV=1" "0.000" "False" "4.455" "2" "1" "1" "1" "399" "44.2" "5.10" "3.62" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04670" "64121" "ENSG00000116954" "RRAGC" "hsa:64121; Q9H202; Q9H8Q8; Q9HB90" "Target of rapamycin signaling; Orexin receptor pathway; 2q37 copy number variation syndrome" "Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Amino acids regulate mTORC1; mTORC1-mediated signalling; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "10" "0" "1.047" "1.177" "0.903" "1.101" "1.235" "1.252" "1.213" "1.200" "0.534" "154.5" "161.7" "181.9" "139.5" "170.2" "190.9" "193.4" "187.5" "185.4" "82.5" "" "" "" "" "" "" "" "" "" "" "81.8" "89.7" "104.2" "64.2" "92.1" "106.2" "113.8" "102.3" "104.0" "82.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2737319948807008641" "False" "High" "IsMasterProtein" "Q9H8G2" "Caspase activity and apoptosis inhibitor 1 OS=Homo sapiens OX=9606 GN=CAAP1 PE=1 SV=2" "0.000" "False" "4.452" "4" "1" "1" "1" "361" "38.3" "4.72" "0.00" "1" "other biological processes" "" "" "Pf15335" "79886" "ENSG00000120159" "CAAP1" "B4DWT4; D3DRK4; hsa:79886; Q5VY32; Q6IPE6; Q96C59; Q9H8G2" "Acute viral myocarditis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5964921006077680004" "False" "High" "IsMasterProtein" "Q92522" "Histone H1.10 OS=Homo sapiens OX=9606 GN=H1-10 PE=1 SV=1" "0.000" "False" "4.450" "4" "1" "1" "1" "213" "22.5" "10.76" "3.23" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "8971" "ENSG00000184897" "H1-10" "hsa:8971; Q92522" "" "" "0" "0" "0.941" "0.911" "1.004" "1.081" "0.927" "0.839" "0.864" "1.024" "0.630" "139.0" "130.8" "126.6" "139.6" "150.3" "128.8" "116.7" "120.2" "142.4" "87.5" "" "" "" "" "" "" "" "" "" "" "73.6" "72.5" "72.5" "64.3" "81.3" "71.7" "68.7" "65.6" "79.9" "87.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2588914150961402946" "False" "High" "IsMasterProtein" "Q9H492" "Microtubule-associated proteins 1A/1B light chain 3A OS=Homo sapiens OX=9606 GN=MAP1LC3A PE=1 SV=2" "0.000" "False" "4.438" "12" "2" "2" "2" "121" "14.3" "8.68" "5.44" "2" "cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf02991" "84557" "ENSG00000101460" "MAP1LC3A" "E1P5P4; E1P5P5; hsa:84557; Q9BXW5; Q9H492" "Nanoparticle triggered autophagic cell death; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; CAMKK2 pathway; Clock-controlled autophagy in bone metabolism; 2q37 copy number variation syndrome; ADHD and autism (ASD) linked metabolic pathways and SNP; HDAC6 interactions in the central nervous system" "Macroautophagy; PINK1-PRKN Mediated Mitophagy; Receptor Mediated Mitophagy" "12" "0" "0.988" "0.931" "0.889" "0.912" "0.901" "0.913" "0.939" "0.855" "0.715" "356.4" "352.2" "332.0" "316.9" "325.0" "321.0" "325.6" "334.6" "304.8" "254.7" "" "" "" "" "" "" "" "" "" "" "188.7" "195.3" "190.1" "145.9" "175.8" "178.5" "191.6" "182.7" "171.0" "254.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6209481463683659801" "False" "High" "IsMasterProtein" "Q71F23" "Centromere protein U OS=Homo sapiens OX=9606 GN=CENPU PE=1 SV=1" "0.000" "False" "4.435" "4" "1" "1" "1" "418" "47.5" "9.13" "3.56" "1" "cell cycle OR cell proliferation;developmental processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf13097" "79682" "ENSG00000151725" "CENPU" "A2RRD9; hsa:79682; Q09GN2; Q32Q71; Q71F23; Q9H5G1" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Deposition of new CENPA-containing nucleosomes at the centromere; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "1.258" "1.263" "1.646" "1.525" "1.394" "1.652" "1.331" "1.337" "1.078" "32.1" "40.4" "40.6" "52.9" "49.0" "44.8" "53.0" "42.8" "42.9" "34.6" "" "" "" "" "" "" "" "" "" "" "17.0" "22.4" "23.2" "24.3" "26.5" "24.9" "31.2" "23.3" "24.1" "34.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8782034775898615298" "False" "High" "IsMasterProtein" "Q96NC0" "Zinc finger matrin-type protein 2 OS=Homo sapiens OX=9606 GN=ZMAT2 PE=1 SV=1" "0.000" "False" "4.431" "7" "2" "4" "2" "199" "23.6" "9.01" "12.26" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf12171" "153527" "ENSG00000146007" "ZMAT2" "hsa:153527; Q96NC0" "" "mRNA Splicing - Major Pathway" "1" "0" "0.947" "1.023" "0.980" "0.948" "0.860" "0.911" "1.063" "0.928" "0.458" "907.3" "859.5" "928.4" "889.1" "859.8" "780.5" "826.7" "964.5" "842.0" "415.7" "" "" "" "" "" "" "" "" "" "" "480.4" "476.6" "531.7" "409.5" "465.2" "434.2" "486.5" "526.5" "472.3" "415.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5951829502980748262" "False" "High" "IsMasterProtein" "Q92989" "Polyribonucleotide 5'-hydroxyl-kinase Clp1 OS=Homo sapiens OX=9606 GN=CLP1 PE=1 SV=1" "0.000" "False" "4.430" "4" "2" "2" "2" "425" "47.6" "6.62" "4.46" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf06807, Pf16573, Pf16575" "10978" "ENSG00000172409" "CLP1" "B2R7J6; B4DTI8; hsa:10978; Q92989" "mRNA processing" "tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6530118680274496318" "False" "High" "IsMasterProtein" "Q9UHB7" "AF4/FMR2 family member 4 OS=Homo sapiens OX=9606 GN=AFF4 PE=1 SV=1" "0.000" "False" "4.430" "1" "1" "1" "1" "1163" "127.4" "9.31" "3.19" "1" "stress response;other biological processes" "nucleus;other cell component" "" "Pf05110, Pf18875, Pf18876" "27125" "ENSG00000072364" "AFF4" "B2RP19; B7WPD2; hsa:27125; Q498B2; Q59FB3; Q6P592; Q8TDR1; Q9P0E4; Q9UHB7" "" "RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex" "3" "0" "0.974" "0.862" "0.985" "1.173" "1.055" "1.148" "1.285" "1.426" "1.013" "94.7" "92.3" "81.6" "93.3" "111.0" "99.9" "108.7" "121.7" "135.0" "95.9" "" "" "" "" "" "" "" "" "" "" "50.1" "51.2" "46.7" "43.0" "60.1" "55.6" "64.0" "66.4" "75.8" "95.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "935705506060532462" "False" "High" "IsMasterProtein" "A0A0U1RRE5" "Negative regulator of P-body association OS=Homo sapiens OX=9606 GN=NBDY PE=1 SV=1" "0.000" "False" "4.429" "12" "1" "1" "1" "68" "7.0" "9.42" "2.75" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other cell component" "" "" "550643" "ENSG00000204272" "NBDY" "A0A0U1RRE5" "" "" "0" "0" "0.928" "1.047" "1.094" "0.865" "0.860" "0.844" "0.888" "0.931" "0.777" "173.4" "160.9" "181.5" "189.8" "150.0" "149.1" "146.4" "154.0" "161.4" "134.7" "" "" "" "" "" "" "" "" "" "" "91.8" "89.2" "103.9" "87.4" "81.1" "83.0" "86.1" "84.1" "90.6" "134.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3570886289104636423" "False" "High" "IsMasterProtein" "Q9NYP9" "Protein Mis18-alpha OS=Homo sapiens OX=9606 GN=MIS18A PE=1 SV=1" "0.000" "False" "4.425" "6" "2" "2" "2" "233" "25.8" "5.20" "5.48" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03226" "54069" "ENSG00000159055" "MIS18A" "B2R562; hsa:54069; Q542Z0; Q9NYP9" "" "Deposition of new CENPA-containing nucleosomes at the centromere" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6609542144732775052" "False" "High" "IsMasterProtein" "Q92615" "La-related protein 4B OS=Homo sapiens OX=9606 GN=LARP4B PE=1 SV=3" "0.000" "False" "4.417" "1" "1" "1" "1" "738" "80.5" "6.92" "3.30" "1" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05383" "23185" "ENSG00000107929" "LARP4B" "A7MD20; hsa:23185; Q5T3R3; Q5T3R4; Q5T3R5; Q68CY4; Q92615" "" "" "0" "0" "1.106" "1.016" "1.394" "1.170" "0.956" "2.086" "2.104" "1.792" "1.408" "79.9" "88.3" "81.2" "111.4" "93.5" "76.4" "166.6" "168.0" "143.1" "112.4" "" "" "" "" "" "" "" "" "" "" "42.3" "49.0" "46.5" "51.3" "50.6" "42.5" "98.1" "91.7" "80.3" "112.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7606738261010209794" "False" "High" "IsMasterProtein" "Q7Z569" "BRCA1-associated protein OS=Homo sapiens OX=9606 GN=BRAP PE=1 SV=2" "0.000" "False" "4.401" "3" "2" "2" "2" "592" "67.3" "5.92" "4.61" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02148, Pf07576, Pf13639" "8315" "ENSG00000089234" "BRAP" "B4DRM1; B9EGS8; hsa:8315; O43238; O75341; Q7Z569" "Ras signaling" "RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Negative regulation of MAPK pathway" "6" "0" "1.086" "0.965" "0.876" "1.038" "1.103" "1.225" "1.220" "1.481" "2.831" "40.5" "44.0" "39.1" "35.5" "42.1" "44.7" "49.6" "49.5" "60.0" "114.8" "" "" "" "" "" "" "" "" "" "" "21.5" "24.4" "22.4" "16.3" "22.8" "24.9" "29.2" "27.0" "33.7" "114.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6108294970833743211" "False" "High" "IsMasterProtein" "Q5XUX1" "F-box/WD repeat-containing protein 9 OS=Homo sapiens OX=9606 GN=FBXW9 PE=1 SV=3" "0.000" "False" "4.397" "3" "2" "2" "2" "458" "50.7" "6.48" "5.38" "2" "" "cytosol" "" "Pf00400, Pf12937" "84261" "ENSG00000132004" "FBXW9" "B3KVP7; hsa:84261; Q5XUX1; Q9BT89" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Association of TriC/CCT with target proteins during biosynthesis" "3" "0" "1.050" "0.853" "0.970" "0.991" "0.956" "0.964" "0.901" "0.947" "0.650" "359.0" "377.0" "306.1" "348.1" "355.9" "343.4" "346.2" "323.6" "340.0" "233.2" "" "" "" "" "" "" "" "" "" "" "190.1" "209.0" "175.3" "160.3" "192.5" "191.0" "203.7" "176.7" "190.7" "233.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5986646952840969808" "False" "High" "IsMasterProtein" "Q9BUE6" "Iron-sulfur cluster assembly 1 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=ISCA1 PE=1 SV=1" "0.000" "False" "4.394" "20" "2" "2" "2" "129" "14.2" "9.07" "1.68" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01521" "81689" "ENSG00000135070" "ISCA1" "B3KP34; B4DJI5; hsa:81689; Q8ND75; Q9BUE6; Q9BZR2" "" "Mitochondrial iron-sulfur cluster biogenesis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6884862282451345768" "False" "High" "IsMasterProtein" "Q9Y232" "Chromodomain Y-like protein OS=Homo sapiens OX=9606 GN=CDYL PE=1 SV=2" "0.000" "False" "4.384" "2" "1" "1" "1" "598" "66.4" "9.45" "3.80" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00378, Pf00385" "9425" "ENSG00000153046" "CDYL" "A8K6D6; B4DLG4; hsa:9425; Q0VDG7; Q32NC5; Q5VX99; Q6P7T5; Q9BWZ2; Q9Y232; Q9Y424" "" "" "0" "0" "0.939" "0.942" "1.124" "1.138" "1.255" "1.865" "1.785" "1.806" "1.688" "118.6" "111.4" "111.7" "133.3" "135.0" "148.8" "221.2" "211.7" "214.2" "200.2" "" "" "" "" "" "" "" "" "" "" "62.8" "61.8" "64.0" "61.4" "73.0" "82.8" "130.2" "115.6" "120.1" "200.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7643769137675685694" "False" "High" "IsMasterProtein" "P82933" "Small ribosomal subunit protein uS9m OS=Homo sapiens OX=9606 GN=MRPS9 PE=1 SV=2" "0.000" "False" "4.380" "5" "2" "2" "2" "396" "45.8" "9.51" "1.86" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf00380" "64965" "ENSG00000135972" "MRPS9" "hsa:64965; P82933; Q6PG40" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.264" "1.034" "1.016" "0.957" "0.900" "0.787" "0.699" "0.837" "3.923" "21.9" "27.6" "22.6" "22.2" "20.9" "19.7" "17.2" "15.3" "18.3" "85.8" "" "" "" "" "" "" "" "" "" "" "11.6" "15.3" "12.9" "10.2" "11.3" "10.9" "10.1" "8.3" "10.3" "85.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1998622485497627376" "False" "High" "IsMasterProtein" "Q8NFP7" "Diphosphoinositol polyphosphate phosphohydrolase 3-alpha OS=Homo sapiens OX=9606 GN=NUDT10 PE=1 SV=1" "0.000" "False" "4.379" "5" "1" "1" "1" "164" "18.5" "5.68" "3.20" "1" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00293" "170685" "ENSG00000122824" "NUDT10" "A8K7D7; D3DX69; hsa:170685; Q86VK1; Q86VR0; Q8NFP7" "" "Synthesis of pyrophosphates in the cytosol" "1" "0" "1.003" "1.045" "0.952" "0.975" "0.957" "1.039" "0.990" "0.906" "4.855" "59.6" "59.8" "62.3" "56.7" "58.1" "57.0" "61.9" "59.0" "54.0" "289.4" "" "" "" "" "" "" "" "" "" "" "31.6" "33.1" "35.7" "26.1" "31.4" "31.7" "36.4" "32.2" "30.3" "289.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9008676394331225875" "False" "High" "IsMasterProtein" "Q9ULV3" "Cip1-interacting zinc finger protein OS=Homo sapiens OX=9606 GN=CIZ1 PE=1 SV=2" "0.000" "False" "4.377" "3" "2" "2" "2" "898" "100.0" "6.11" "5.76" "2" "other biological processes" "plasma membrane;other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf12171" "25792" "ENSG00000148337" "CIZ1" "A8K9J8; B4E131; B7ZAS8; hsa:25792; Q5SYW3; Q5SYW5; Q8WU72; Q9H868; Q9NYM8; Q9UHK4; Q9ULV3; Q9Y3F9; Q9Y3G0" "" "" "0" "0" "1.192" "0.930" "0.986" "1.205" "1.098" "1.130" "1.194" "1.127" "0.778" "25.1" "29.9" "23.3" "24.7" "30.2" "27.5" "28.3" "30.0" "28.3" "19.5" "" "" "" "" "" "" "" "" "" "" "13.3" "16.6" "13.4" "11.4" "16.4" "15.3" "16.7" "16.4" "15.9" "19.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5588774124192242024" "False" "High" "IsMasterProtein" "P54132" "RecQ-like DNA helicase BLM OS=Homo sapiens OX=9606 GN=BLM PE=1 SV=1" "0.000" "False" "4.371" "1" "1" "1" "1" "1417" "158.9" "7.49" "2.64" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf00570, Pf08072, Pf09382, Pf16124, Pf16202, Pf16204" "641" "ENSG00000197299" "BLM" "hsa:641; P54132; Q52M96" "Primary ovarian insufficiency" "Meiotic recombination; Resolution of D-loop Structures through Holliday Junction Intermediates; SUMOylation of DNA damage response and repair proteins; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Processive synthesis on the C-strand of the telomere" "18" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "61926280635528933" "False" "High" "IsMasterProtein" "O60885" "Bromodomain-containing protein 4 OS=Homo sapiens OX=9606 GN=BRD4 PE=1 SV=2" "0.000" "False" "4.352" "2" "2" "2" "1" "1362" "152.1" "9.19" "2.37" "2" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00439, Pf17035, Pf17105" "23476" "ENSG00000141867" "BRD4" "hsa:23476; O60433; O60885; Q4G0X8; Q86YS8; Q96PD3" "VEGFA-VEGFR2 signaling; 7q11.23 copy number variation syndrome" "Potential therapeutics for SARS" "3" "1" "1.161" "0.814" "1.111" "1.160" "1.101" "1.188" "0.998" "1.020" "1.849" "76.6" "89.0" "62.3" "85.1" "88.9" "84.4" "91.0" "76.5" "78.1" "141.6" "" "" "" "" "" "" "" "" "" "" "40.6" "49.3" "35.7" "39.2" "48.1" "46.9" "53.6" "41.7" "43.8" "141.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3220884936245267041" "False" "High" "IsMasterProtein" "Q8WUA7" "TBC1 domain family member 22A OS=Homo sapiens OX=9606 GN=TBC1D22A PE=1 SV=2" "0.000" "False" "4.349" "3" "2" "2" "2" "517" "59.1" "5.97" "5.20" "2" "" "" "enzyme regulator activity;other molecular function" "Pf00566" "25771" "ENSG00000054611" "TBC1D22A" "B0QYI2; B0QYI3; B9A6M3; hsa:25771; Q5TE47; Q6ZUH2; Q8WUA7; Q92680; Q9BVD6; Q9UGG0; Q9UGT2; Q9UGU6; Q9UH25; Q9Y4W5" "" "" "0" "0" "0.901" "0.873" "1.051" "1.249" "0.837" "1.163" "0.950" "1.139" "0.615" "24.0" "21.7" "21.0" "25.3" "30.0" "20.1" "27.9" "22.8" "27.4" "14.8" "" "" "" "" "" "" "" "" "" "" "12.7" "12.0" "12.0" "11.6" "16.2" "11.2" "16.4" "12.5" "15.3" "14.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2715683272122769400" "False" "High" "IsMasterProtein" "Q14197" "Large ribosomal subunit protein mL62 OS=Homo sapiens OX=9606 GN=MRPL58 PE=1 SV=1" "0.000" "False" "4.345" "5" "1" "1" "1" "206" "23.6" "10.07" "3.13" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "plasma membrane;other membranes;mitochondrion;translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "Pf00472" "3396" "ENSG00000167862" "MRPL58" "B2RAD1; hsa:3396; Q14197; Q53HM7; Q53Y11" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.162" "1.074" "1.373" "1.248" "1.159" "1.019" "0.870" "0.979" "1.571" "126.6" "147.2" "136.0" "173.9" "158.1" "146.8" "129.1" "110.1" "123.9" "198.9" "" "" "" "" "" "" "" "" "" "" "67.1" "81.6" "77.9" "80.1" "85.5" "81.7" "76.0" "60.1" "69.5" "198.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8649705542655534815" "False" "High" "IsMasterProtein" "Q8N573" "Oxidation resistance protein 1 OS=Homo sapiens OX=9606 GN=OXR1 PE=1 SV=2" "0.000" "False" "4.344" "3" "2" "2" "2" "874" "97.9" "5.47" "4.28" "2" "stress response;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf01476, Pf07534" "55074" "ENSG00000164830" "OXR1" "A6NK11; A8KA34; B3KXL1; B7Z402; B7Z8N5; D3HIS6; hsa:55074; Q3LIB5; Q6ZVK9; Q8N573; Q8N8V0; Q9H266; Q9NWC7" "" "" "0" "0" "0.792" "0.824" "0.872" "0.973" "0.790" "0.911" "0.733" "0.871" "0.581" "81.3" "64.4" "67.0" "70.9" "79.1" "64.2" "74.1" "59.6" "70.8" "47.3" "" "" "" "" "" "" "" "" "" "" "43.1" "35.7" "38.4" "32.7" "42.8" "35.7" "43.6" "32.5" "39.7" "47.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5208446995115017732" "False" "High" "IsMasterProtein" "Q5TFE4" "5'-nucleotidase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NT5DC1 PE=1 SV=1" "0.000" "False" "4.343" "3" "2" "3" "2" "455" "51.8" "6.35" "8.10" "2" "" "" "other molecular function" "Pf05761" "221294" "ENSG00000178425" "NT5DC1" "B2RND9; B3KR35; hsa:221294; Q5TFE4; Q6XYD5" "" "" "0" "0" "0.983" "0.950" "0.861" "0.794" "0.906" "0.765" "0.954" "0.932" "0.505" "437.7" "430.2" "416.0" "376.9" "347.5" "396.6" "334.8" "417.4" "408.1" "220.9" "" "" "" "" "" "" "" "" "" "" "231.8" "238.5" "238.2" "173.6" "188.0" "220.6" "197.0" "227.8" "228.9" "220.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9053740260663860944" "False" "High" "IsMasterProtein" "Q9NZN8" "CCR4-NOT transcription complex subunit 2 OS=Homo sapiens OX=9606 GN=CNOT2 PE=1 SV=1" "0.000" "False" "4.342" "4" "2" "3" "2" "540" "59.7" "7.66" "6.80" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf04153" "4848" "ENSG00000111596" "CNOT2" "hsa:4848; Q9H3E0; Q9NSX5; Q9NWR6; Q9NZN8; Q9P028" "" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "3" "0" "1.214" "1.080" "1.416" "1.508" "1.307" "2.312" "2.299" "1.891" "2.547" "38.1" "46.3" "41.2" "54.0" "57.5" "49.8" "88.2" "87.7" "72.1" "97.1" "" "" "" "" "" "" "" "" "" "" "20.2" "25.7" "23.6" "24.9" "31.1" "27.7" "51.9" "47.8" "40.4" "97.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7697367026041443041" "False" "High" "IsMasterProtein" "Q96A49" "Synapse-associated protein 1 OS=Homo sapiens OX=9606 GN=SYAP1 PE=1 SV=1" "0.000" "False" "4.341" "6" "2" "2" "2" "352" "39.9" "4.53" "4.65" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf03909" "94056" "ENSG00000169895" "SYAP1" "hsa:94056; Q68CP1; Q96A49; Q96C60; Q96JQ6; Q96T20" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4950317330528062097" "False" "High" "IsMasterProtein" "Q92466" "DNA damage-binding protein 2 OS=Homo sapiens OX=9606 GN=DDB2 PE=1 SV=1" "0.000" "False" "4.339" "2" "1" "1" "1" "427" "47.8" "9.47" "3.64" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400" "1643" "ENSG00000134574" "DDB2" "B2R875; hsa:1643; Q76E54; Q76E55; Q76E56; Q76E57; Q92466" "miRNA regulation of DNA damage response; miRNA regulation of p53 pathway in prostate cancer; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Small cell lung cancer; Hepatitis B infection; Melanoma; Nucleotide excision repair; DNA repair pathways, full network; p53 transcriptional gene network; Nucleotide excision repair in xeroderma pigmentosum ; DNA damage response" "TP53 Regulates Transcription of DNA Repair Genes; Dual Incision in GG-NER; Ub-specific processing proteases; Neddylation; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "21" "0" "1.037" "1.143" "1.170" "1.056" "1.108" "1.089" "1.165" "1.188" "0.983" "131.6" "136.5" "150.4" "154.1" "139.0" "145.8" "143.4" "153.4" "156.4" "129.4" "" "" "" "" "" "" "" "" "" "" "69.7" "75.7" "86.2" "71.0" "75.2" "81.1" "84.4" "83.7" "87.7" "129.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3241628752191747033" "False" "High" "IsMasterProtein" "Q9Y6W3" "Calpain-7 OS=Homo sapiens OX=9606 GN=CAPN7 PE=1 SV=1" "0.000" "False" "4.339" "1" "1" "1" "1" "813" "92.6" "7.65" "2.15" "1" "protein metabolism;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00648, Pf01067, Pf04212" "23473" "ENSG00000131375" "CAPN7" "hsa:23473; Q9Y6W3" "Integrin-mediated cell adhesion" "Degradation of the extracellular matrix" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1882529908578060163" "False" "High" "IsMasterProtein" "Q9HAS0" "Protein Njmu-R1 OS=Homo sapiens OX=9606 GN=C17orf75 PE=1 SV=2" "0.000" "False" "4.336" "5" "2" "2" "2" "396" "44.6" "5.03" "4.19" "2" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "" "Pf15053" "64149" "ENSG00000108666" "C17orf75" "hsa:64149; Q7Z2H4; Q9HAS0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2766829585988969351" "False" "High" "IsMasterProtein" "O75190" "DnaJ homolog subfamily B member 6 OS=Homo sapiens OX=9606 GN=DNAJB6 PE=1 SV=2" "0.000" "False" "4.335" "5" "2" "2" "2" "326" "36.1" "9.16" "2.37" "2" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00226" "10049" "ENSG00000105993" "DNAJB6" "A4D232; A8K7D8; A8KAG0; B4DN73; E9PCZ2; hsa:10049; O75190; O95806; Q53EN8; Q59EF2; Q6FIC8; Q75MA2; Q9UIK6" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "1.061" "0.950" "1.206" "1.104" "1.040" "1.010" "0.901" "0.983" "1.567" "117.0" "124.2" "111.1" "141.2" "129.2" "121.7" "118.2" "105.4" "115.1" "183.4" "" "" "" "" "" "" "" "" "" "" "62.0" "68.9" "63.7" "65.0" "69.9" "67.7" "69.6" "57.6" "64.5" "183.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4578961420069997890" "False" "High" "IsMasterProtein" "P31930" "Cytochrome b-c1 complex subunit 1, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRC1 PE=1 SV=3" "0.000" "False" "4.334" "3" "2" "2" "1" "480" "52.6" "6.37" "6.01" "2" "other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00675, Pf05193" "7384" "ENSG00000010256" "UQCRC1" "B2R7R8; hsa:7384; P31930; Q96DD2" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "Respiratory electron transport" "4" "0" "0.993" "1.091" "1.078" "1.113" "1.158" "0.894" "0.958" "0.820" "0.952" "168.2" "166.9" "183.5" "181.3" "187.2" "194.8" "150.3" "161.1" "137.9" "160.0" "" "" "" "" "" "" "" "" "" "" "89.0" "92.5" "105.1" "83.5" "101.3" "108.3" "88.5" "88.0" "77.4" "160.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3674589448003344018" "False" "High" "IsMasterProtein" "Q5T749" "Keratinocyte proline-rich protein OS=Homo sapiens OX=9606 GN=KPRP PE=1 SV=1" "0.000" "False" "4.332" "4" "2" "2" "2" "579" "64.1" "8.27" "4.60" "2" "" "other cell component" "" "" "448834" "ENSG00000203786" "KPRP" "hsa:448834; Q5T749" "" "" "0" "0" "0.616" "0.421" "0.714" "0.491" "0.681" "0.705" "0.703" "0.472" "0.442" "56.7" "34.9" "23.9" "40.4" "27.8" "38.6" "40.0" "39.8" "26.8" "25.0" "" "" "" "" "" "" "" "" "" "" "30.0" "19.3" "13.7" "18.6" "15.0" "21.5" "23.5" "21.8" "15.0" "25.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2682819818401791106" "False" "High" "IsMasterProtein" "Q9NZJ0" "Denticleless protein homolog OS=Homo sapiens OX=9606 GN=DTL PE=1 SV=3" "0.000" "False" "4.329" "1" "1" "1" "1" "730" "79.4" "8.87" "2.87" "1" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400" "51514" "ENSG00000143476" "DTL" "A8K8H8; D3DT98; hsa:51514; Q5VT77; Q96SN0; Q9NW03; Q9NW34; Q9NWM5; Q9NZJ0" "" "Neddylation; Recognition of DNA damage by PCNA-containing replication complex" "2" "0" "0.952" "1.064" "0.930" "1.060" "1.229" "0.993" "0.795" "1.029" "2.243" "83.5" "79.5" "88.8" "77.6" "88.5" "102.6" "82.9" "66.4" "85.9" "187.2" "" "" "" "" "" "" "" "" "" "" "44.2" "44.1" "50.9" "35.7" "47.9" "57.1" "48.8" "36.2" "48.2" "187.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7676030556128945513" "False" "High" "IsMasterProtein" "Q8WXX7" "Autism susceptibility gene 2 protein OS=Homo sapiens OX=9606 GN=AUTS2 PE=1 SV=1" "0.000" "False" "4.329" "1" "2" "2" "2" "1259" "138.9" "9.38" "5.20" "2" "cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15336" "26053" "ENSG00000158321" "AUTS2" "A4D1Y9; L7QET3; L7QF75; Q5D049; Q6PJU5; Q8WXX7; Q9Y4F2" "" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6795582567929622559" "False" "High" "IsMasterProtein" "P61916" "NPC intracellular cholesterol transporter 2 OS=Homo sapiens OX=9606 GN=NPC2 PE=1 SV=1" "0.000" "False" "4.328" "9" "2" "3" "2" "151" "16.6" "7.65" "9.32" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle" "transporter activity;other molecular function" "Pf02221" "10577" "ENSG00000119655" "NPC2" "B4DQV7; P61916; Q15668; Q29413" "TYROBP causal network in microglia; Degradation pathway of sphingolipids, including diseases; Ebola virus infection in host; Cholesterol metabolism; Fatty acids and lipoproteins transport in hepatocytes" "Neutrophil degranulation; LDL clearance" "7" "0" "0.848" "1.001" "0.733" "0.842" "0.837" "0.785" "1.025" "0.901" "0.464" "523.6" "444.1" "524.4" "383.8" "441.1" "438.3" "411.1" "537.0" "471.8" "242.7" "" "" "" "" "" "" "" "" "" "" "277.3" "246.2" "300.3" "176.8" "238.7" "243.8" "241.9" "293.1" "264.6" "242.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3928347610324358029" "False" "High" "IsMasterProtein" "Q9HAP6" "Protein lin-7 homolog B OS=Homo sapiens OX=9606 GN=LIN7B PE=1 SV=1" "0.000" "False" "4.324" "5" "1" "1" "1" "207" "22.9" "8.66" "3.82" "1" "cell-cell signaling;transport;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00595, Pf02828" "64130" "ENSG00000104863" "LIN7B" "hsa:64130; Q9HAP6" "" "Assembly and cell surface presentation of NMDA receptors; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle; RHO GTPases Activate Rhotekin and Rhophilins" "4" "0" "1.146" "1.215" "0.919" "1.159" "1.168" "1.024" "1.313" "1.329" "1.130" "90.9" "104.1" "110.5" "83.6" "105.4" "106.2" "93.1" "119.3" "120.8" "102.7" "" "" "" "" "" "" "" "" "" "" "48.1" "57.7" "63.3" "38.5" "57.0" "59.1" "54.8" "65.1" "67.8" "102.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7135249905505884321" "False" "High" "IsMasterProtein" "P0DTL6" "Zinc finger TRAF-type-containing protein 1 OS=Homo sapiens OX=9606 GN=ZFTRAF1 PE=1 SV=1" "0.000" "False" "4.321" "4" "1" "1" "1" "404" "43.8" "6.76" "2.60" "1" "" "nucleus;other cell component" "other molecular function" "" "157542; 50626; 84773" "ENSG00000187954" "ZFTRAF1" "B3KSX0; D3DWM3; E9PJD7; hsa:157542; hsa:50626; hsa:84773; P0DTL6; Q6ZMK1; Q9BSF6; Q9BSU6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3877552904475964910" "False" "High" "IsMasterProtein" "Q9NX63" "MICOS complex subunit MIC19 OS=Homo sapiens OX=9606 GN=CHCHD3 PE=1 SV=1" "0.000" "False" "4.315" "4" "1" "1" "1" "227" "26.1" "8.28" "3.71" "1" "cell organization and biogenesis" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf05300" "54927" "ENSG00000106554" "CHCHD3" "hsa:54927; Q9NX63" "" "Cristae formation; Mitochondrial protein import" "2" "0" "0.928" "1.114" "0.956" "0.926" "1.033" "0.892" "1.080" "1.005" "0.147" "236.0" "219.1" "262.9" "225.6" "218.5" "243.8" "210.5" "254.9" "237.2" "34.7" "" "" "" "" "" "" "" "" "" "" "125.0" "121.5" "150.6" "103.9" "118.2" "135.6" "123.9" "139.1" "133.1" "34.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2974134927255505490" "False" "High" "IsMasterProtein" "Q6VY07" "Phosphofurin acidic cluster sorting protein 1 OS=Homo sapiens OX=9606 GN=PACS1 PE=1 SV=2" "0.000" "False" "4.312" "2" "2" "3" "2" "963" "104.8" "7.74" "8.30" "2" "other biological processes" "cytosol;ER/Golgi" "other molecular function" "Pf10254" "55690" "ENSG00000175115" "PACS1" "hsa:55690; Q6PJY6; Q6PKB6; Q6VY07; Q7Z590; Q7Z5W4; Q8N8K6; Q96MW0; Q9NW92; Q9ULP5" "" "Nef mediated downregulation of MHC class I complex cell surface expression" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7848338417616042821" "False" "High" "IsMasterProtein" "P35270" "Sepiapterin reductase OS=Homo sapiens OX=9606 GN=SPR PE=1 SV=1" "0.000" "False" "4.308" "10" "3" "3" "3" "261" "28.0" "8.05" "4.39" "3" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00106" "6697" "ENSG00000116096" "SPR" "A8K741; D6W5H2; hsa:6697; P35270; Q53GI9; Q9UBB1" "" "eNOS activation; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "2" "0" "0.881" "1.097" "1.074" "1.099" "0.993" "1.001" "1.295" "0.950" "0.694" "33.5" "29.5" "36.8" "36.0" "36.8" "33.3" "33.6" "43.4" "31.8" "23.3" "" "" "" "" "" "" "" "" "" "" "17.7" "16.4" "21.1" "16.6" "19.9" "18.5" "19.7" "23.7" "17.9" "23.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7603913648578901731" "False" "High" "IsMasterProtein" "Q5VWZ2" "Lysophospholipase-like protein 1 OS=Homo sapiens OX=9606 GN=LYPLAL1 PE=1 SV=3" "0.000" "False" "4.304" "6" "2" "5" "2" "237" "26.3" "7.84" "10.43" "2" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf02230" "127018" "ENSG00000143353" "LYPLAL1" "A8K677; hsa:127018; Q5VWZ2; Q5VWZ3; Q7Z4A3; Q96AV0" "" "" "0" "0" "1.014" "0.909" "1.067" "1.017" "1.036" "1.064" "1.009" "0.900" "0.992" "375.0" "380.3" "340.9" "400.2" "381.4" "388.5" "399.1" "378.3" "337.4" "371.9" "" "" "" "" "" "" "" "" "" "" "198.6" "210.8" "195.3" "184.3" "206.4" "216.1" "234.9" "206.5" "189.3" "371.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2121660018572641519" "False" "High" "IsMasterProtein" "Q9Y6I9" "Testis-expressed protein 264 OS=Homo sapiens OX=9606 GN=TEX264 PE=1 SV=1" "0.000" "False" "4.302" "4" "1" "1" "1" "313" "34.2" "4.86" "2.50" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "" "51368" "ENSG00000164081" "TEX264" "B3KN87; hsa:51368; Q9UKD7; Q9Y6I9" "" "Platelet degranulation" "1" "0" "0.737" "0.859" "1.048" "0.846" "0.866" "1.251" "1.433" "1.528" "0.553" "46.8" "34.5" "40.2" "49.0" "39.5" "40.5" "58.5" "67.0" "71.4" "25.9" "" "" "" "" "" "" "" "" "" "" "24.8" "19.1" "23.0" "22.6" "21.4" "22.5" "34.4" "36.6" "40.1" "25.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6429762109324514714" "False" "High" "IsMasterProtein" "O75607" "Nucleoplasmin-3 OS=Homo sapiens OX=9606 GN=NPM3 PE=1 SV=3" "0.000" "False" "4.299" "8" "1" "1" "1" "178" "19.3" "4.63" "3.77" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03066" "10360" "ENSG00000107833" "NPM3" "hsa:10360; O75607; Q9UNY6" "" "" "0" "0" "0.767" "0.776" "0.679" "0.812" "0.810" "0.723" "0.650" "0.518" "0.477" "399.9" "306.6" "310.4" "271.6" "324.7" "324.1" "289.0" "260.1" "207.1" "190.7" "" "" "" "" "" "" "" "" "" "" "211.8" "170.0" "177.8" "125.1" "175.6" "180.3" "170.1" "142.0" "116.2" "190.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3864595288643475005" "False" "High" "IsMasterProtein" "P61011" "Signal recognition particle subunit SRP54 OS=Homo sapiens OX=9606 GN=SRP54 PE=1 SV=1" "0.000" "False" "4.295" "2" "1" "1" "1" "504" "55.7" "8.75" "2.40" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00448, Pf02881, Pf02978" "6729" "ENSG00000100883" "SRP54" "B2R759; B4DUW6; hsa:6729; P13624; P61011" "VEGFA-VEGFR2 signaling; mRNA processing" "SRP-dependent cotranslational protein targeting to membrane" "3" "0" "0.847" "0.815" "0.951" "0.915" "0.986" "1.044" "0.757" "0.795" "1.631" "45.2" "38.3" "36.8" "43.0" "41.4" "44.6" "47.2" "34.2" "35.9" "73.8" "" "" "" "" "" "" "" "" "" "" "24.0" "21.3" "21.1" "19.8" "22.4" "24.8" "27.8" "18.7" "20.2" "73.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-115181160460478952" "False" "High" "IsMasterProtein" "P35754" "Glutaredoxin-1 OS=Homo sapiens OX=9606 GN=GLRX PE=1 SV=2" "0.000" "False" "4.293" "10" "1" "1" "1" "106" "11.8" "8.09" "3.01" "1" "other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00462" "2745" "ENSG00000173221" "GLRX" "B2R4L2; hsa:2745; P35754; Q3KQS1; Q6ICT1" "One-carbon metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "1.190" "1.103" "1.164" "1.328" "1.081" "0.914" "1.303" "1.104" "0.672" "33.3" "39.6" "36.7" "38.8" "44.2" "36.0" "30.5" "43.4" "36.8" "22.4" "" "" "" "" "" "" "" "" "" "" "17.6" "22.0" "21.0" "17.9" "23.9" "20.0" "17.9" "23.7" "20.6" "22.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5869916031675078190" "False" "High" "IsMasterProtein" "O95486" "Protein transport protein Sec24A OS=Homo sapiens OX=9606 GN=SEC24A PE=1 SV=2" "0.000" "False" "4.293" "2" "2" "2" "2" "1093" "119.7" "7.66" "3.91" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10802" "ENSG00000113615" "SEC24A" "A8MVW3; hsa:10802; O95486; Q8WUV2; Q96GP7" "Sterol regulatory element-binding proteins (SREBP) signaling" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7356302297912569782" "False" "High" "IsMasterProtein" "O75400" "Pre-mRNA-processing factor 40 homolog A OS=Homo sapiens OX=9606 GN=PRPF40A PE=1 SV=2" "0.000" "False" "4.289" "1" "1" "1" "1" "957" "108.7" "7.56" "2.85" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf00397, Pf01846" "55660" "ENSG00000196504" "PRPF40A" "hsa:55660; O43856; O75400; O75404; Q8TBQ1; Q9H782; Q9NWU9; Q9P0Q2; Q9Y5A8" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.991" "1.103" "0.815" "0.964" "1.185" "1.760" "2.398" "2.118" "1.462" "77.5" "76.7" "85.4" "63.1" "74.7" "91.8" "136.3" "185.7" "164.1" "113.2" "" "" "" "" "" "" "" "" "" "" "41.0" "42.6" "48.9" "29.1" "40.4" "51.1" "80.2" "101.4" "92.1" "113.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3667791429140774240" "False" "High" "IsMasterProtein" "Q9NUM4" "Transmembrane protein 106B OS=Homo sapiens OX=9606 GN=TMEM106B PE=1 SV=2" "0.000" "False" "4.285" "4" "1" "1" "1" "274" "31.1" "6.99" "3.43" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle" "other molecular function" "Pf07092, Pf21002" "54664" "ENSG00000106460" "TMEM106B" "A4D108; hsa:54664; Q53FL9; Q8N4L0; Q9NUM4" "" "" "0" "0" "1.166" "1.172" "0.849" "1.134" "1.331" "1.057" "1.129" "1.321" "0.644" "88.5" "103.2" "103.7" "75.1" "100.4" "117.8" "93.5" "99.9" "116.9" "57.0" "" "" "" "" "" "" "" "" "" "" "46.9" "57.2" "59.4" "34.6" "54.3" "65.5" "55.0" "54.5" "65.6" "57.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6220946712320524294" "False" "High" "IsMasterProtein" "Q7L5D6" "Golgi to ER traffic protein 4 homolog OS=Homo sapiens OX=9606 GN=GET4 PE=1 SV=1" "0.000" "False" "4.281" "7" "2" "2" "2" "327" "36.5" "5.41" "1.86" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04190" "51608" "ENSG00000239857" "GET4" "A4D2Q1; B3KNC7; hsa:51608; Q7L5D6; Q9UFC9; Q9Y309" "" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "1" "0" "1.169" "1.172" "1.338" "1.227" "1.188" "1.123" "0.993" "1.030" "2.772" "44.8" "52.3" "52.4" "59.9" "54.9" "53.2" "50.2" "44.4" "46.1" "124.0" "" "" "" "" "" "" "" "" "" "" "23.7" "29.0" "30.0" "27.6" "29.7" "29.6" "29.6" "24.3" "25.9" "124.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6384522747761550778" "False" "High" "IsMasterProtein" "Q9NUP7" "tRNA:m(4)X modification enzyme TRM13 homolog OS=Homo sapiens OX=9606 GN=TRMT13 PE=1 SV=2" "0.000" "False" "4.279" "2" "1" "2" "1" "481" "54.2" "8.09" "4.49" "1" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf05206, Pf05253, Pf11722" "54482" "ENSG00000122435" "TRMT13" "hsa:54482; Q5VVL0; Q9NUP7; Q9NW65" "" "tRNA modification in the nucleus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5625848183831329232" "False" "High" "IsMasterProtein" "Q6VMQ6" "Activating transcription factor 7-interacting protein 1 OS=Homo sapiens OX=9606 GN=ATF7IP PE=1 SV=3" "0.000" "False" "4.277" "2" "2" "2" "2" "1270" "136.3" "4.70" "2.98" "2" "DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf16788, Pf16794" "55729" "ENSG00000171681" "ATF7IP" "F5GX74; G3V1U0; hsa:55729; Q4G0T9; Q6P3T3; Q6VMQ6; Q86XW5; Q9NVJ9; Q9NWC2; Q9Y4X8" "" "PKMTs methylate histone lysines" "1" "0" "0.931" "1.000" "0.880" "0.997" "0.944" "1.044" "1.125" "1.013" "0.983" "320.4" "298.4" "320.4" "282.0" "319.4" "302.6" "334.4" "360.6" "324.6" "314.9" "" "" "" "" "" "" "" "" "" "" "169.7" "165.4" "183.5" "129.9" "172.8" "168.3" "196.8" "196.8" "182.1" "314.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5422158606125759469" "False" "High" "IsMasterProtein" "Q86U42" "Polyadenylate-binding protein 2 OS=Homo sapiens OX=9606 GN=PABPN1 PE=1 SV=3" "0.000" "False" "4.274" "3" "1" "2" "1" "306" "32.7" "5.06" "5.42" "1" "RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "8106" "ENSG00000100836" "PABPN1" "D3DS49; hsa:8106; O43484; Q86U42" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Z-decay: degradation of maternal mRNAs by zygotically expressed factors; Inhibition of Host mRNA Processing and RNA Silencing" "7" "0" "0.998" "0.998" "0.979" "1.073" "0.988" "1.182" "1.367" "1.218" "1.451" "307.8" "307.1" "307.2" "301.4" "330.3" "304.3" "363.9" "420.7" "375.1" "446.6" "" "" "" "" "" "" "" "" "" "" "163.0" "170.3" "175.9" "138.8" "178.7" "169.3" "214.1" "229.6" "210.4" "446.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5378807455886263528" "False" "High" "IsMasterProtein" "Q13740" "CD166 antigen OS=Homo sapiens OX=9606 GN=ALCAM PE=1 SV=2" "0.000" "False" "4.269" "4" "2" "2" "2" "583" "65.1" "6.25" "4.03" "2" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf08205, Pf13927" "214" "ENSG00000170017" "ALCAM" "B2RNS3; B4DTU0; hsa:214; O60892; Q13740; Q1HGM8; Q1HGM9; Q6PEY4; Q6ZS95" "" "L1CAM interactions" "1" "0" "0.880" "1.049" "0.898" "0.905" "0.845" "0.833" "0.915" "0.874" "0.474" "73.6" "64.8" "77.2" "66.1" "66.6" "62.2" "61.3" "67.3" "64.3" "34.9" "" "" "" "" "" "" "" "" "" "" "39.0" "35.9" "44.2" "30.4" "36.0" "34.6" "36.1" "36.7" "36.1" "34.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5241124612822470915" "False" "High" "IsMasterProtein" "P36639" "Oxidized purine nucleoside triphosphate hydrolase OS=Homo sapiens OX=9606 GN=NUDT1 PE=1 SV=4" "0.000" "False" "4.268" "8" "1" "1" "1" "156" "17.9" "5.08" "2.47" "1" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293" "4521" "ENSG00000106268" "NUDT1" "A4D205; hsa:4521; P36639; Q6LES7; Q6P0Y6; Q7Z7N6; Q8IV95; Q9UBM0; Q9UBM9" "" "" "0" "0" "1.126" "0.768" "1.059" "1.012" "1.027" "0.996" "1.009" "0.919" "1.405" "40.2" "45.2" "30.8" "42.5" "40.6" "41.2" "40.0" "40.5" "36.9" "56.4" "" "" "" "" "" "" "" "" "" "" "21.3" "25.1" "17.7" "19.6" "22.0" "22.9" "23.5" "22.1" "20.7" "56.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4156627100779081460" "False" "High" "IsMasterProtein" "Q02446" "Transcription factor Sp4 OS=Homo sapiens OX=9606 GN=SP4 PE=1 SV=2" "0.000" "False" "4.266" "3" "1" "1" "1" "784" "81.9" "7.05" "2.64" "1" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "6671" "ENSG00000105866" "SP4" "hsa:6671; O60402; Q02446; Q32M52" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "High" "High" "High" "Not Found" "Not Found" "High" "High" "Not Found" "1" "" "340121106600756603" "False" "High" "IsMasterProtein" "Q9UPY3" "Endoribonuclease Dicer OS=Homo sapiens OX=9606 GN=DICER1 PE=1 SV=3" "0.000" "False" "4.266" "1" "1" "1" "1" "1922" "218.5" "5.68" "2.32" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf00636, Pf02170, Pf03368, Pf20930, Pf20931, Pf20932" "23405" "ENSG00000100697" "DICER1" "A7E2D3; B3KRG4; E0AD28; hsa:23405; O95943; Q9UPY3; Q9UQ02" "miRNA biogenesis; exRNA mechanism of action and biogenesis; Hypoxia-mediated EMT and stemness; mRNA processing; Fragile X syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "M-decay: degradation of maternal mRNAs by maternally stored factors; MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis; tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6144698658960758490" "False" "High" "IsMasterProtein" "Q8IXB1" "DnaJ homolog subfamily C member 10 OS=Homo sapiens OX=9606 GN=DNAJC10 PE=1 SV=2" "0.000" "False" "4.261" "1" "1" "2" "1" "793" "91.0" "7.18" "4.38" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi" "other molecular function" "Pf00085, Pf00226" "54431" "ENSG00000077232" "DNAJC10" "hsa:54431; Q17RJ6; Q3B7W8; Q4ZG06; Q53QT7; Q6UWZ6; Q86T61; Q8IXB1; Q8NC82; Q8TD87; Q96K38; Q96K44; Q96K54; Q9NSY6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2990327377986760395" "False" "High" "IsMasterProtein" "Q8N9Q2" "Protein SREK1IP1 OS=Homo sapiens OX=9606 GN=SREK1IP1 PE=1 SV=1" "0.000" "False" "4.250" "10" "2" "2" "2" "155" "18.2" "9.85" "6.40" "2" "RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "Pf13917" "285672" "ENSG00000153006" "SREK1IP1" "hsa:285672; Q32NC8; Q8N9Q2" "" "" "0" "0" "1.103" "1.154" "1.121" "1.134" "1.029" "1.348" "1.266" "1.303" "0.491" "147.5" "162.7" "170.3" "165.4" "167.3" "151.8" "198.8" "186.8" "192.2" "72.4" "" "" "" "" "" "" "" "" "" "" "78.1" "90.2" "97.5" "76.2" "90.5" "84.4" "117.0" "102.0" "107.8" "72.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-949132700508493695" "False" "High" "IsMasterProtein" "Q8WW59" "SPRY domain-containing protein 4 OS=Homo sapiens OX=9606 GN=SPRYD4 PE=1 SV=3" "0.000" "False" "4.245" "9" "2" "2" "2" "207" "23.1" "6.93" "2.52" "2" "" "nucleus" "" "Pf00622" "283377" "ENSG00000176422" "SPRYD4" "A8K7A5; hsa:283377; Q8WW59" "" "" "0" "0" "1.030" "0.918" "1.055" "0.973" "0.953" "0.988" "0.940" "0.928" "0.763" "394.9" "406.6" "362.4" "416.5" "384.2" "376.2" "390.2" "371.3" "366.6" "301.3" "" "" "" "" "" "" "" "" "" "" "209.1" "225.4" "207.6" "191.8" "207.8" "209.2" "229.7" "202.7" "205.7" "301.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-902532758451743562" "False" "High" "IsMasterProtein" "Q96B26" "Exosome complex component RRP43 OS=Homo sapiens OX=9606 GN=EXOSC8 PE=1 SV=1" "0.000" "False" "4.244" "3" "1" "1" "1" "276" "30.0" "5.30" "3.72" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "11340" "ENSG00000120699" "EXOSC8" "hsa:11340; O43480; Q5TBA5; Q96B26" "" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "6" "0" "0.923" "0.959" "0.867" "0.966" "1.126" "0.904" "1.044" "0.992" "0.515" "200.3" "184.8" "192.1" "173.7" "193.5" "225.5" "181.1" "209.2" "198.6" "103.2" "" "" "" "" "" "" "" "" "" "" "106.0" "102.4" "110.0" "80.0" "104.7" "125.4" "106.6" "114.2" "111.4" "103.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6180191668945880169" "False" "High" "IsMasterProtein" "Q9H269" "Vacuolar protein sorting-associated protein 16 homolog OS=Homo sapiens OX=9606 GN=VPS16 PE=1 SV=2" "0.000" "False" "4.238" "1" "1" "1" "1" "839" "94.6" "6.77" "2.80" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf04840, Pf04841" "64601" "ENSG00000215305" "VPS16" "hsa:64601; Q5JUB1; Q8WU31; Q96EE7; Q96N92; Q9H1Q4; Q9H1Q5; Q9H269" "Ebola virus infection in host; Network map of SARS-CoV-2 signaling pathway" "SARS-CoV-2 modulates autophagy" "3" "0" "0.884" "0.681" "0.831" "1.078" "0.871" "0.983" "0.773" "0.987" "3.936" "77.8" "68.8" "53.0" "64.7" "83.9" "67.8" "76.6" "60.1" "76.8" "306.3" "" "" "" "" "" "" "" "" "" "" "41.2" "38.1" "30.3" "29.8" "45.4" "37.7" "45.1" "32.8" "43.1" "306.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7975170816643306332" "False" "High" "IsMasterProtein" "O43543" "DNA repair protein XRCC2 OS=Homo sapiens OX=9606 GN=XRCC2 PE=1 SV=1" "0.000" "False" "4.233" "4" "1" "2" "1" "280" "31.9" "6.04" "6.37" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423" "7516" "ENSG00000196584" "XRCC2" "B2R925; hsa:7516; O43543" "Male infertility; Primary ovarian insufficiency" "Resolution of D-loop Structures through Holliday Junction Intermediates; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2" "11" "0" "1.211" "1.183" "1.163" "1.337" "1.259" "1.110" "1.046" "0.968" "0.779" "86.3" "104.5" "102.1" "100.4" "115.3" "108.7" "95.7" "90.3" "83.5" "67.3" "" "" "" "" "" "" "" "" "" "" "45.7" "57.9" "58.5" "46.2" "62.4" "60.4" "56.3" "49.3" "46.9" "67.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "583939558635172856" "False" "High" "IsMasterProtein" "Q9Y4P1" "Cysteine protease ATG4B OS=Homo sapiens OX=9606 GN=ATG4B PE=1 SV=2" "0.000" "False" "4.227" "3" "1" "1" "1" "393" "44.3" "5.07" "3.08" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03416, Pf20166" "23192" "ENSG00000168397" "ATG4B" "B7WNK2; hsa:23192; Q53NU4; Q6ZUV8; Q8WYM9; Q96K07; Q96K96; Q96SZ1; Q9Y2F2; Q9Y4P1" "2q37 copy number variation syndrome" "Macroautophagy" "2" "0" "1.269" "1.114" "1.380" "0.978" "0.931" "1.364" "0.446" "1.174" "6.571" "33.1" "42.0" "36.9" "45.7" "32.4" "30.8" "45.1" "14.8" "38.9" "217.6" "" "" "" "" "" "" "" "" "" "" "17.5" "23.3" "21.1" "21.0" "17.5" "17.1" "26.6" "8.1" "21.8" "217.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7638543548033193713" "False" "High" "IsMasterProtein" "Q00765" "Receptor expression-enhancing protein 5 OS=Homo sapiens OX=9606 GN=REEP5 PE=1 SV=3" "0.000" "False" "4.223" "4" "1" "2" "1" "189" "21.5" "8.10" "5.72" "1" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi" "" "Pf03134" "7905" "ENSG00000129625" "REEP5" "B7Z681; D3DT04; hsa:7905; Q00765; Q04198; Q5QGT0; Q9BWH9" "" "" "0" "0" "1.007" "1.011" "0.904" "1.024" "1.024" "0.888" "0.873" "0.963" "0.592" "437.7" "440.8" "442.6" "395.5" "448.0" "448.1" "388.7" "382.2" "421.7" "259.2" "" "" "" "" "" "" "" "" "" "" "231.8" "244.4" "253.5" "182.1" "242.4" "249.3" "228.8" "208.6" "236.5" "259.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8900361841491851768" "False" "High" "IsMasterProtein" "Q8N567" "Zinc finger CCHC domain-containing protein 9 OS=Homo sapiens OX=9606 GN=ZCCHC9 PE=1 SV=2" "0.000" "False" "4.212" "8" "2" "2" "2" "271" "30.5" "9.17" "4.54" "2" "" "nucleus" "other molecular function" "Pf00098" "84240" "ENSG00000131732" "ZCCHC9" "B2RAE7; hsa:84240; Q8N567; Q9H027" "" "" "0" "0" "0.852" "0.988" "0.909" "1.042" "0.920" "1.032" "0.897" "1.095" "0.225" "56.0" "47.7" "55.3" "50.9" "58.4" "51.5" "57.8" "50.2" "61.3" "12.6" "" "" "" "" "" "" "" "" "" "" "29.6" "26.5" "31.7" "23.4" "31.6" "28.7" "34.0" "27.4" "34.4" "12.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6537965283186170392" "False" "High" "IsMasterProtein" "Q9UM13" "Anaphase-promoting complex subunit 10 OS=Homo sapiens OX=9606 GN=ANAPC10 PE=1 SV=1" "0.000" "False" "4.201" "11" "2" "2" "2" "185" "21.2" "9.06" "4.26" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf03256" "10393" "ENSG00000164162" "ANAPC10" "D3DNZ7; hsa:10393; Q2V500; Q9UG51; Q9UM13; Q9Y5R0" "Cell cycle" "Separation of Sister Chromatids; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "1.121" "0.907" "1.416" "1.095" "0.971" "1.295" "1.229" "0.979" "1.601" "195.5" "219.2" "177.3" "276.8" "214.0" "189.8" "253.1" "240.2" "191.4" "312.9" "" "" "" "" "" "" "" "" "" "" "103.5" "121.5" "101.5" "127.5" "115.8" "105.6" "149.0" "131.1" "107.4" "312.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3037258603534985886" "False" "High" "IsMasterProtein" "Q12974" "Protein tyrosine phosphatase type IVA 2 OS=Homo sapiens OX=9606 GN=PTP4A2 PE=1 SV=1" "0.000" "False" "4.190" "5" "1" "1" "1" "167" "19.1" "8.37" "3.55" "1" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00102" "8073" "ENSG00000184007" "PTP4A2" "A8K9I8; B4DM39; D3DPP0; E9PGJ6; hsa:8073; O00649; Q12974; Q15197; Q15259; Q15260; Q15261; R4GN50" "" "RAB geranylgeranylation" "1" "0" "0.988" "0.892" "0.863" "1.077" "0.951" "0.966" "0.896" "0.969" "0.669" "191.3" "189.0" "170.6" "165.0" "205.9" "181.8" "184.7" "171.4" "185.4" "127.9" "" "" "" "" "" "" "" "" "" "" "101.3" "104.8" "97.7" "76.0" "111.4" "101.1" "108.7" "93.5" "104.0" "127.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6721724367357589607" "False" "High" "IsMasterProtein" "Q6IPU0" "Centromere protein P OS=Homo sapiens OX=9606 GN=CENPP PE=1 SV=1" "0.000" "False" "4.184" "3" "1" "1" "1" "288" "33.1" "6.27" "2.25" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;nucleus;other cell component" "" "Pf13096" "401541" "ENSG00000188312; ENSG00000291348" "CENPP" "B3KRA5; B3KS17; hsa:401541; Q5T9F8; Q5T9F9; Q6IPU0" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "697554350722155722" "False" "High" "IsMasterProtein" "Q96B45" "BLOC-1-related complex subunit 7 OS=Homo sapiens OX=9606 GN=BORCS7 PE=1 SV=2" "0.000" "False" "4.182" "9" "1" "2" "1" "106" "11.7" "6.79" "5.79" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf16088" "119032" "ENSG00000166275" "BORCS7" "B2R488; B3KUW4; C9K0X3; hsa:119032; Q96B45" "" "" "0" "0" "1.057" "1.033" "1.066" "1.043" "1.009" "1.165" "1.095" "1.037" "0.967" "390.9" "413.0" "403.9" "416.8" "407.8" "394.3" "455.5" "427.9" "405.2" "378.1" "" "" "" "" "" "" "" "" "" "" "207.0" "229.0" "231.3" "191.9" "220.7" "219.3" "268.1" "233.6" "227.3" "378.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2025748717046247647" "False" "High" "IsMasterProtein" "Q8IV63" "Serine/threonine-protein kinase VRK3 OS=Homo sapiens OX=9606 GN=VRK3 PE=1 SV=2" "0.000" "False" "4.175" "4" "1" "1" "1" "474" "52.8" "9.04" "2.88" "1" "signal transduction;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf13240" "51231" "ENSG00000105053" "VRK3" "A6NEG5; A8KA53; hsa:51231; Q502Y2; Q8IV63; Q9P2V8" "" "ERKs are inactivated" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9157929292758815644" "False" "High" "IsMasterProtein" "Q96A35" "Large ribosomal subunit protein uL24m OS=Homo sapiens OX=9606 GN=MRPL24 PE=1 SV=1" "0.000" "False" "4.163" "5" "1" "1" "1" "216" "24.9" "9.29" "2.90" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00467, Pf17136" "79590" "ENSG00000143314" "MRPL24" "D3DVC8; hsa:79590; Q53G65; Q53HT0; Q5SYZ9; Q5SZ00; Q5SZ02; Q96A35; Q96Q70; Q9H7G3" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6717831225161761415" "False" "High" "IsMasterProtein" "P46100" "Transcriptional regulator ATRX OS=Homo sapiens OX=9606 GN=ATRX PE=1 SV=6" "0.000" "False" "4.161" "1" "2" "2" "2" "2492" "282.4" "6.55" "4.33" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf17981" "546" "ENSG00000085224" "ATRX" "D3DTE2; P46100; P51068; Q15886; Q59FB5; Q59H31; Q5H9A2; Q5JWI4; Q7Z2J1; Q9H0Z1; Q9NTS3" "Pathways affected in adenoid cystic carcinoma" "Inhibition of DNA recombination at telomere; Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations; Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations" "4" "0" "0.951" "0.732" "0.882" "0.912" "0.825" "1.329" "1.224" "1.193" "0.600" "85.6" "81.5" "62.7" "75.5" "78.1" "70.7" "113.8" "104.8" "102.1" "51.4" "" "" "" "" "" "" "" "" "" "" "45.3" "45.2" "35.9" "34.8" "42.3" "39.3" "67.0" "57.2" "57.3" "51.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5243510255652215024" "False" "High" "IsMasterProtein" "Q9Y448" "Small kinetochore-associated protein OS=Homo sapiens OX=9606 GN=KNSTRN PE=1 SV=2" "0.000" "False" "4.150" "3" "1" "1" "1" "316" "35.4" "6.30" "3.11" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "90417" "ENSG00000128944" "KNSTRN" "B4DXA7; hsa:90417; Q147U5; Q32Q57; Q5ISJ0; Q6P2S5; Q6PJM0; Q86XB4; Q9Y448" "Leukocyte-intrinsic Hippo pathway functions" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4031307080017597315" "False" "High" "IsMasterProtein" "P18077" "Large ribosomal subunit protein eL33 OS=Homo sapiens OX=9606 GN=RPL35A PE=1 SV=2" "0.000" "False" "4.142" "13" "2" "2" "2" "110" "12.5" "11.06" "5.25" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01247" "6165" "ENSG00000182899" "RPL35A" "hsa:6165; P18077; Q08ES9; Q9BVN7" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.230" "1.068" "1.175" "0.989" "1.298" "0.830" "1.030" "0.918" "0.900" "145.3" "178.7" "155.2" "170.7" "143.7" "188.6" "120.7" "149.7" "133.4" "130.7" "" "" "" "" "" "" "" "" "" "" "76.9" "99.1" "88.9" "78.6" "77.7" "104.9" "71.0" "81.7" "74.9" "130.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "203506742472389879" "False" "High" "IsMasterProtein" "Q5RL73" "RNA-binding protein 48 OS=Homo sapiens OX=9606 GN=RBM48 PE=1 SV=1" "0.000" "False" "4.141" "3" "1" "2" "1" "367" "41.8" "8.72" "2.90" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "" "84060" "ENSG00000127993" "RBM48" "B7Z2K5; B7ZL51; hsa:84060; Q5H9T2; Q5RL73; Q8IYW7; Q96NS0; Q9H0V7" "" "" "0" "0" "1.092" "1.108" "1.131" "1.082" "1.095" "1.312" "1.521" "1.748" "0.795" "185.8" "202.9" "206.0" "210.2" "201.0" "203.4" "243.9" "282.7" "324.8" "147.8" "" "" "" "" "" "" "" "" "" "" "98.4" "112.5" "118.0" "96.8" "108.8" "113.2" "143.5" "154.3" "182.2" "147.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3337700356256422645" "False" "High" "IsMasterProtein" "Q86XR2" "Protein Niban 3 OS=Homo sapiens OX=9606 GN=NIBAN3 PE=1 SV=2" "0.000" "False" "4.137" "2" "1" "1" "1" "697" "77.4" "8.63" "3.35" "1" "" "" "" "" "199786" "ENSG00000167483" "NIBAN3" "B4DNU3; B4DVN7; hsa:199786; Q7Z6H6; Q86XR2; Q86XR3; Q86XR4; Q8TEQ3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2898803308841595735" "False" "High" "IsMasterProtein" "O00182" "Galectin-9 OS=Homo sapiens OX=9606 GN=LGALS9 PE=1 SV=2" "0.000" "False" "4.136" "2" "1" "1" "1" "355" "39.5" "9.17" "3.17" "1" "stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00337" "3965" "ENSG00000168961" "LGALS9" "A7VJG6; F8W9W4; hsa:3965; O00182; O14532; O75028; Q3B8N1; Q53FQ0; Q8WYQ7; Q9NQ58" "Vitamin D receptor pathway; Pleural mesothelioma; Immune infiltration in pancreatic cancer" "Interleukin-2 family signaling" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-932703795777546839" "False" "High" "IsMasterProtein" "Q96BJ3" "Axin interactor, dorsalization-associated protein OS=Homo sapiens OX=9606 GN=AIDA PE=1 SV=1" "0.000" "False" "4.135" "5" "1" "1" "1" "306" "35.0" "6.55" "2.79" "1" "developmental processes;other biological processes" "other membranes;other cell component" "other molecular function" "Pf08910, Pf14186" "64853" "ENSG00000186063" "AIDA" "A8K1F0; hsa:64853; Q49A81; Q5JRA4; Q658P1; Q96BJ3; Q9H9E8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7445573923015050179" "False" "High" "IsMasterProtein" "Q9BYC8" "Large ribosomal subunit protein bL32m OS=Homo sapiens OX=9606 GN=MRPL32 PE=1 SV=1" "0.000" "False" "4.134" "12" "1" "1" "1" "188" "21.4" "9.73" "3.13" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01783" "64983" "ENSG00000106591" "MRPL32" "hsa:64983; Q96Q68; Q9BYC8; Q9P098" "" "Mitochondrial protein degradation; Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "1.233" "1.075" "1.493" "1.225" "1.247" "1.113" "0.715" "1.176" "0.901" "17.3" "21.3" "18.5" "25.8" "21.1" "21.5" "19.2" "12.3" "20.3" "15.6" "" "" "" "" "" "" "" "" "" "" "9.1" "11.8" "10.6" "11.9" "11.4" "12.0" "11.3" "6.7" "11.4" "15.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1914895012756735579" "False" "High" "IsMasterProtein" "P08240" "Signal recognition particle receptor subunit alpha OS=Homo sapiens OX=9606 GN=SRPRA PE=1 SV=2" "0.000" "False" "4.133" "2" "1" "1" "1" "638" "69.8" "8.95" "2.47" "1" "cell organization and biogenesis;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf00448, Pf02881, Pf04086" "6734" "ENSG00000182934" "SRPRA" "A6NIB3; B2R5Z8; B4E0H3; E9PJS4; hsa:6734; P08240; Q9BVJ4" "" "XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane" "2" "0" "1.045" "1.097" "1.188" "1.028" "1.137" "1.125" "0.990" "1.095" "1.062" "68.0" "71.1" "74.6" "80.8" "69.9" "77.3" "76.5" "67.4" "74.5" "72.2" "" "" "" "" "" "" "" "" "" "" "36.0" "39.4" "42.7" "37.2" "37.8" "43.0" "45.0" "36.8" "41.8" "72.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7890622308646159318" "False" "High" "IsMasterProtein" "Q93083" "Metallothionein-1L OS=Homo sapiens OX=9606 GN=MT1L PE=1 SV=1" "0.000" "True" "4.120" "13" "1" "1" "1" "61" "6.1" "7.96" "3.59" "1" "stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00131" "" "" "MT1L" "Q93083" "" "" "0" "0" "1.213" "1.212" "1.159" "1.095" "1.074" "1.180" "0.948" "1.046" "0.511" "423.6" "513.9" "513.3" "490.9" "464.1" "454.9" "499.7" "401.5" "443.2" "216.5" "" "" "" "" "" "" "" "" "" "" "224.3" "284.9" "294.0" "226.1" "251.1" "253.0" "294.1" "219.2" "248.6" "216.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1645614495321622240" "False" "High" "IsMasterProtein" "P57678" "Gem-associated protein 4 OS=Homo sapiens OX=9606 GN=GEMIN4 PE=1 SV=2" "0.000" "False" "4.117" "1" "1" "1" "1" "1058" "120.0" "6.04" "3.23" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "" "50628" "ENSG00000179409" "GEMIN4" "hsa:50628; P57678; Q9NZS7; Q9UG32; Q9Y4Q2" "" "SARS-CoV-2 modulates host translation machinery; snRNP Assembly" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-377515032386624778" "False" "High" "IsMasterProtein" "P78346" "Ribonuclease P protein subunit p30 OS=Homo sapiens OX=9606 GN=RPP30 PE=1 SV=1" "0.000" "False" "4.115" "7" "2" "2" "2" "268" "29.3" "8.91" "2.28" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01876" "10556" "ENSG00000148688" "RPP30" "B2R799; E9PB02; hsa:10556; P78346" "" "Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus" "2" "0" "1.280" "1.097" "0.908" "1.206" "1.033" "1.122" "1.139" "1.239" "0.706" "36.5" "46.8" "40.1" "33.2" "44.0" "37.7" "41.0" "41.6" "45.3" "25.8" "" "" "" "" "" "" "" "" "" "" "19.3" "25.9" "22.9" "15.3" "23.8" "21.0" "24.1" "22.7" "25.4" "25.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8811809090486028216" "False" "High" "IsMasterProtein" "Q6QNY0" "Biogenesis of lysosome-related organelles complex 1 subunit 3 OS=Homo sapiens OX=9606 GN=BLOC1S3 PE=1 SV=1" "0.000" "False" "4.112" "8" "2" "2" "2" "202" "21.2" "5.15" "5.39" "2" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "cytosol;ER/Golgi;other cell component" "transporter activity" "Pf15753" "388552" "ENSG00000189114" "BLOC1S3" "B2RXB8; hsa:388552; Q6QNY0" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "1.062" "1.009" "0.960" "1.046" "1.044" "1.044" "0.936" "1.111" "0.718" "263.5" "279.8" "266.0" "253.1" "275.7" "275.1" "275.1" "246.6" "292.8" "189.1" "" "" "" "" "" "" "" "" "" "" "139.5" "155.1" "152.3" "116.5" "149.1" "153.0" "161.9" "134.6" "164.3" "189.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4923515790283792107" "False" "High" "IsMasterProtein" "Q7Z309" "PABIR family member 2 OS=Homo sapiens OX=9606 GN=PABIR2 PE=1 SV=2" "0.000" "False" "4.111" "5" "1" "1" "1" "247" "26.9" "6.37" "2.25" "1" "" "" "enzyme regulator activity" "" "159090" "ENSG00000156504" "PABIR2" "A8K902; hsa:159090; Q6PIM2; Q6ZU47; Q6ZV64; Q6ZVE4; Q7Z309; Q8TB75" "" "" "0" "0" "0.926" "1.263" "1.094" "1.129" "0.927" "0.890" "1.090" "0.831" "0.677" "60.0" "55.6" "75.8" "65.7" "67.7" "55.6" "53.4" "65.4" "49.9" "40.6" "" "" "" "" "" "" "" "" "" "" "31.8" "30.8" "43.4" "30.2" "36.7" "30.9" "31.4" "35.7" "28.0" "40.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4827521234037792457" "False" "High" "IsMasterProtein" "Q9NUS5" "AP-5 complex subunit sigma-1 OS=Homo sapiens OX=9606 GN=AP5S1 PE=1 SV=1" "0.000" "False" "4.104" "10" "2" "2" "2" "200" "22.5" "6.87" "2.07" "2" "DNA metabolism;stress response;transport" "other membranes;cytosol;nucleus;other cytoplasmic organelle" "" "Pf15001" "55317" "ENSG00000125843" "AP5S1" "B3KSD0; D3DVY7; hsa:55317; Q9NUS5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2091961222017639990" "False" "High" "IsMasterProtein" "Q13123" "Protein Red OS=Homo sapiens OX=9606 GN=IK PE=1 SV=3" "0.000" "False" "4.102" "2" "1" "1" "1" "557" "65.6" "6.64" "3.09" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07807, Pf07808" "3550" "ENSG00000113141" "IK" "hsa:3550; Q13123; Q6IPD8" "" "mRNA Splicing - Major Pathway" "1" "0" "0.874" "1.177" "1.118" "1.224" "1.195" "1.424" "1.165" "1.548" "2.242" "68.6" "60.0" "80.8" "76.7" "84.0" "82.0" "97.7" "80.0" "106.3" "153.9" "" "" "" "" "" "" "" "" "" "" "36.3" "33.3" "46.3" "35.3" "45.4" "45.6" "57.5" "43.7" "59.6" "153.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6933895130976224833" "False" "High" "IsMasterProtein" "P23511" "Nuclear transcription factor Y subunit alpha OS=Homo sapiens OX=9606 GN=NFYA PE=1 SV=2" "0.000" "False" "4.099" "6" "1" "1" "1" "347" "36.9" "8.94" "2.17" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02045" "4800" "ENSG00000001167" "NFYA" "hsa:4800; P23511; Q8IXU0" "Sterol regulatory element-binding proteins (SREBP) signaling; Wnt signaling pathway and pluripotency; Sudden infant death syndrome (SIDS) susceptibility pathways" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum stress; ATF6 (ATF6-alpha) activates chaperone genes" "8" "0" "1.044" "1.206" "0.954" "1.325" "1.294" "1.431" "1.392" "1.222" "0.724" "30.5" "31.8" "36.8" "29.1" "40.4" "39.5" "43.6" "42.5" "37.3" "22.1" "" "" "" "" "" "" "" "" "" "" "16.2" "17.6" "21.1" "13.4" "21.9" "22.0" "25.7" "23.2" "20.9" "22.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-501406145012788137" "False" "High" "IsMasterProtein" "Q9H2K0" "Translation initiation factor IF-3, mitochondrial OS=Homo sapiens OX=9606 GN=MTIF3 PE=1 SV=4" "0.000" "False" "4.098" "6" "2" "2" "2" "278" "31.7" "9.69" "3.27" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "translation activity;nucleic acid binding activity" "Pf05198" "219402" "ENSG00000122033" "MTIF3" "hsa:219402; Q05BL8; Q5W0V0; Q86X68; Q9H2K0" "" "Mitochondrial translation initiation" "1" "0" "0.979" "0.981" "0.887" "0.873" "0.853" "0.835" "0.804" "0.940" "0.719" "119.4" "116.9" "117.2" "105.9" "104.2" "101.8" "99.7" "96.0" "112.2" "85.9" "" "" "" "" "" "" "" "" "" "" "63.2" "64.8" "67.1" "48.8" "56.4" "56.6" "58.7" "52.4" "62.9" "85.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7499774936196670588" "False" "High" "IsMasterProtein" "A0A3B3IU46" "RNA guanine-N7 methyltransferase-activating subunit-like protein OS=Homo sapiens OX=9606 GN=RAMACL PE=3 SV=1" "0.000" "False" "4.091" "12" "2" "3" "2" "118" "14.4" "8.40" "6.15" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf15320" "" "ENSG00000235272" "RAMACL" "A0A3B3IU46" "" "" "0" "0" "0.937" "1.050" "0.843" "0.890" "0.930" "0.884" "1.040" "0.960" "0.447" "926.1" "867.7" "972.6" "780.8" "824.2" "860.9" "818.4" "963.4" "889.5" "413.7" "" "" "" "" "" "" "" "" "" "" "490.4" "481.1" "557.0" "359.6" "445.9" "478.9" "481.7" "525.9" "499.0" "413.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7054599493317546199" "False" "High" "IsMasterProtein" "Q8TCC3" "Large ribosomal subunit protein uL30m OS=Homo sapiens OX=9606 GN=MRPL30 PE=1 SV=1" "0.000" "False" "4.091" "7" "1" "1" "1" "161" "18.5" "9.99" "4.21" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00327" "51263" "ENSG00000185414" "MRPL30" "A6NIC6; D3DVI0; D3DVI3; hsa:51263; Q0D2Q7; Q6ZTP4; Q8TCC3; Q96Q69; Q9P0N0" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.066" "1.204" "1.054" "0.956" "1.092" "1.003" "0.809" "0.976" "1.398" "158.9" "169.4" "191.4" "167.5" "151.9" "173.6" "159.4" "128.6" "155.1" "222.2" "" "" "" "" "" "" "" "" "" "" "84.2" "93.9" "109.6" "77.1" "82.2" "96.5" "93.8" "70.2" "87.0" "222.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7971569862806086425" "False" "High" "IsMasterProtein" "Q9Y2Z4" "Tyrosine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=YARS2 PE=1 SV=2" "0.000" "False" "4.088" "3" "2" "2" "2" "477" "53.2" "8.98" "4.41" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00579" "51067" "ENSG00000139131" "YARS2" "D3DUW8; hsa:51067; Q9H817; Q9Y2Z4" "Orexin receptor pathway" "Mitochondrial tRNA aminoacylation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3414895648230328268" "False" "High" "IsMasterProtein" "Q92667" "A-kinase anchor protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=AKAP1 PE=1 SV=1" "0.000" "False" "4.085" "2" "2" "2" "2" "903" "97.3" "4.94" "5.43" "2" "stress response;other biological processes" "other membranes;cytosol;mitochondrion" "other molecular function" "Pf00013, Pf00567" "8165" "ENSG00000121057" "AKAP1" "A8K8Q1; D3DTZ0; hsa:8165; Q13320; Q92667; Q9BW14" "G protein signaling pathways" "Factors involved in megakaryocyte development and platelet production; Mitochondrial calcium ion transport" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7993967056221403717" "False" "High" "IsMasterProtein" "Q9BU02" "Thiamine-triphosphatase OS=Homo sapiens OX=9606 GN=THTPA PE=1 SV=3" "0.000" "False" "4.079" "5" "1" "1" "1" "230" "25.6" "4.82" "2.71" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf01928" "79178" "ENSG00000259431" "THTPA" "D3DS50; G3V4J3; hsa:79178; Q9BU02" "" "Vitamin B1 (thiamin) metabolism" "1" "0" "1.199" "1.154" "1.164" "1.307" "1.419" "1.223" "1.174" "1.341" "1.320" "46.6" "55.8" "53.7" "54.2" "60.9" "66.1" "56.9" "54.6" "62.4" "61.5" "" "" "" "" "" "" "" "" "" "" "24.7" "30.9" "30.8" "25.0" "32.9" "36.8" "33.5" "29.8" "35.0" "61.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4805951626840685734" "False" "High" "IsMasterProtein" "P50336" "Protoporphyrinogen oxidase OS=Homo sapiens OX=9606 GN=PPOX PE=1 SV=1" "0.000" "False" "4.078" "2" "1" "1" "1" "477" "50.7" "8.16" "3.29" "1" "other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf01593" "5498" "ENSG00000143224" "PPOX" "D3DVG0; hsa:5498; P50336; Q5VTW8" "Orexin receptor pathway; Hemesynthesis defects and porphyrias; Heme biosynthesis" "Heme biosynthesis" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "967030651674579734" "False" "High" "IsMasterProtein" "Q9NV88" "Integrator complex subunit 9 OS=Homo sapiens OX=9606 GN=INTS9 PE=1 SV=2" "0.000" "False" "4.072" "3" "2" "2" "2" "658" "73.8" "6.33" "4.13" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf10996, Pf16661, Pf21382" "55756" "ENSG00000104299" "INTS9" "B7Z560; B7Z6M5; hsa:55756; O00224; Q8TB16; Q9NV88" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "0.978" "1.001" "1.084" "1.013" "0.988" "0.997" "0.869" "0.866" "0.772" "194.3" "190.0" "194.5" "210.6" "196.9" "192.0" "193.7" "168.9" "168.2" "150.0" "" "" "" "" "" "" "" "" "" "" "102.9" "105.3" "111.4" "97.0" "106.5" "106.8" "114.0" "92.2" "94.4" "150.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4752916691292977805" "False" "High" "IsMasterProtein" "Q15057" "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ACAP2 PE=1 SV=3" "0.000" "False" "4.063" "3" "2" "3" "2" "778" "88.0" "6.80" "6.54" "2" "transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf01412, Pf12796, Pf16746" "23527" "ENSG00000114331" "ACAP2" "A8K2V4; hsa:23527; Q15057; Q8N5Z8; Q9UQR3" "" "" "0" "0" "1.074" "1.082" "1.219" "1.116" "1.150" "1.041" "0.911" "0.961" "1.850" "131.3" "141.1" "142.2" "160.1" "146.6" "151.1" "136.7" "119.7" "126.2" "243.0" "" "" "" "" "" "" "" "" "" "" "69.5" "78.2" "81.4" "73.7" "79.3" "84.0" "80.4" "65.3" "70.8" "243.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4044165242645246749" "False" "High" "IsMasterProtein" "Q8ND82" "Zinc finger protein 280C OS=Homo sapiens OX=9606 GN=ZNF280C PE=1 SV=1" "0.000" "False" "4.061" "2" "1" "1" "1" "737" "83.0" "9.11" "2.62" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13836" "55609" "ENSG00000056277" "ZNF280C" "A8K2V8; hsa:55609; Q8ND82; Q9NXR3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3583354851233029387" "False" "High" "IsMasterProtein" "Q9C0D0" "Phosphatase and actin regulator 1 OS=Homo sapiens OX=9606 GN=PHACTR1 PE=1 SV=3" "0.000" "False" "4.059" "2" "1" "1" "1" "580" "66.3" "6.96" "2.92" "1" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity" "Pf02755" "221692" "ENSG00000112137" "PHACTR1" "A8K1V2; hsa:221692; Q3MJ93; Q5JSJ2; Q9C0D0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6899043111177724007" "False" "High" "IsMasterProtein" "Q15208" "Serine/threonine-protein kinase 38 OS=Homo sapiens OX=9606 GN=STK38 PE=1 SV=1" "0.000" "False" "4.055" "4" "2" "2" "2" "465" "54.2" "7.15" "5.01" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433" "11329" "ENSG00000112079" "STK38" "hsa:11329; Q15208; Q503A1" "Interactome of polycomb repressive complex 2 (PRC2)" "RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7431440183355440202" "False" "High" "IsMasterProtein" "Q9ULL5" "Proline-rich protein 12 OS=Homo sapiens OX=9606 GN=PRR12 PE=1 SV=3" "0.000" "False" "4.054" "1" "1" "1" "1" "2036" "210.9" "7.87" "3.21" "1" "" "nucleus;other cell component" "" "Pf13926" "57479" "ENSG00000126464" "PRR12" "E9PB06; hsa:57479; Q8N4J6; Q9ULL5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1025854285268432181" "False" "High" "IsMasterProtein" "P56377" "AP-1 complex subunit sigma-2 OS=Homo sapiens OX=9606 GN=AP1S2 PE=1 SV=1" "0.000" "False" "4.049" "6" "1" "1" "1" "157" "18.6" "5.47" "2.87" "1" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01217" "8905" "ENSG00000182287" "AP1S2" "B4DSU4; hsa:8905; O95326; P56377; Q9H2N6" "" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "4" "0" "0.930" "0.919" "1.252" "1.051" "0.998" "1.280" "1.110" "1.223" "2.573" "89.3" "83.0" "82.1" "111.8" "93.9" "89.2" "114.3" "99.2" "109.3" "229.8" "" "" "" "" "" "" "" "" "" "" "47.3" "46.0" "47.0" "51.5" "50.8" "49.6" "67.3" "54.1" "61.3" "229.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5448927889689110920" "False" "High" "IsMasterProtein" "Q16539" "Mitogen-activated protein kinase 14 OS=Homo sapiens OX=9606 GN=MAPK14 PE=1 SV=3" "0.000" "False" "4.048" "4" "2" "2" "2" "360" "41.3" "5.78" "5.69" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1432" "ENSG00000112062" "MAPK14" "A6ZJ92; A8K6P4; B0LPH0; B5TY32; hsa:1432; O60776; Q13083; Q14084; Q16539; Q8TDX0" "Physiological and pathological hypertrophy of the heart; Angiogenesis; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Parkinson's disease pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; Alpha 6 beta 4 signaling pathway; Amyotrophic lateral sclerosis (ALS); Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Kit receptor signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; Canonical and non-canonical TGF-B signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; IL-4 signaling pathway; p38 MAPK signaling pathway; Oxidative stress response; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; miRNA role in immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Regulatory circuits of the STAT3 signaling pathway; Leukocyte-intrinsic Hippo pathway functions; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - apoptosis; Host-pathogen interaction of human coronaviruses - MAPK signaling; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; Pleural mesothelioma; Th17 cell differentiation pathway; GDNF signaling; Hippocampal synaptogenesis and neurogenesis; Comprehensive IL-17A signaling; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; IL-19 signaling pathway; Interferon type I signaling pathways; T-cell receptor signaling pathway; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Monoamine transport; Toll-like receptor signaling pathway" "Neutrophil degranulation; p38MAPK events; Oxidative Stress Induced Senescence; Activation of the AP-1 family of transcription factors; Regulation of TP53 Activity through Phosphorylation; VEGFA-VEGFR2 Pathway; Myogenesis; ADP signalling through P2Y purinoceptor 1; NOD1/2 Signaling Pathway; DSCAM interactions; activated TAK1 mediates p38 MAPK activation; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; ERK/MAPK targets; KSRP (KHSRP) binds and destabilizes mRNA; Platelet sensitization by LDL; RHO GTPases Activate NADPH Oxidases; CD163 mediating an anti-inflammatory response" "92" "0" "1.084" "0.832" "0.854" "1.012" "0.987" "1.035" "0.617" "0.995" "3.056" "99.8" "108.2" "83.1" "85.2" "101.0" "98.5" "103.2" "61.6" "99.3" "304.9" "" "" "" "" "" "" "" "" "" "" "52.8" "60.0" "47.6" "39.3" "54.6" "54.8" "60.8" "33.6" "55.7" "304.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7472508916157269106" "False" "High" "IsMasterProtein" "Q9H9P8" "L-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=L2HGDH PE=1 SV=3" "0.000" "False" "4.046" "2" "1" "1" "1" "463" "50.3" "8.15" "3.55" "1" "other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf01266" "79944" "ENSG00000087299" "L2HGDH" "hsa:79944; Q9BRR1; Q9H9P8" "Cerebral organic acidurias, including diseases" "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate" "2" "0" "1.063" "0.948" "1.006" "0.973" "0.957" "0.735" "0.775" "0.803" "0.917" "239.0" "254.0" "226.5" "240.4" "232.6" "228.8" "175.8" "185.2" "191.8" "219.2" "" "" "" "" "" "" "" "" "" "" "126.6" "140.8" "129.7" "110.7" "125.8" "127.3" "103.5" "101.1" "107.6" "219.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2134905287649132421" "False" "High" "IsMasterProtein" "Q9Y312" "Protein AAR2 homolog OS=Homo sapiens OX=9606 GN=AAR2 PE=1 SV=2" "0.000" "False" "4.045" "4" "2" "2" "2" "384" "43.4" "5.96" "5.13" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf05282, Pf20981" "25980" "ENSG00000131043" "AAR2" "E1P5S7; hsa:25980; Q9H4F9; Q9P1P3; Q9UFK9; Q9Y312" "Ciliary landscape" "" "1" "0" "1.024" "1.074" "1.073" "1.075" "0.996" "0.881" "0.730" "1.016" "2.820" "224.0" "229.3" "240.5" "240.3" "240.8" "223.2" "197.3" "163.5" "227.4" "631.6" "" "" "" "" "" "" "" "" "" "" "118.6" "127.1" "137.7" "110.7" "130.3" "124.1" "116.1" "89.2" "127.6" "631.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3231455898363948540" "False" "High" "IsMasterProtein" "Q15833" "Syntaxin-binding protein 2 OS=Homo sapiens OX=9606 GN=STXBP2 PE=1 SV=2" "0.000" "False" "4.028" "2" "1" "1" "1" "593" "66.4" "6.55" "3.12" "1" "cell-cell signaling;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00995" "6813" "ENSG00000076944" "STXBP2" "B4E175; E7EQD5; hsa:6813; Q15833; Q9BU65" "Splicing factor NOVA regulated synaptic proteins; Insulin signaling" "Platelet degranulation ; Other interleukin signaling" "4" "0" "1.129" "0.917" "1.155" "1.054" "1.314" "1.415" "0.816" "0.847" "7.673" "40.1" "45.3" "36.8" "46.3" "42.3" "52.7" "56.8" "32.7" "34.0" "308.0" "" "" "" "" "" "" "" "" "" "" "21.3" "25.1" "21.1" "21.3" "22.9" "29.3" "33.4" "17.9" "19.1" "308.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1448578471139674410" "False" "High" "IsMasterProtein" "Q6PJ69" "E3 ubiquitin-protein ligase TRIM65 OS=Homo sapiens OX=9606 GN=TRIM65 PE=1 SV=3" "0.000" "False" "4.011" "3" "2" "2" "2" "517" "57.3" "6.70" "5.26" "2" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00097, Pf00622, Pf00643" "201292" "ENSG00000141569" "TRIM65" "hsa:201292; Q4G0F0; Q6DKJ6; Q6PJ69; Q9BRP6" "" "" "0" "0" "1.132" "0.986" "1.240" "1.464" "1.046" "1.190" "0.923" "1.008" "2.879" "245.3" "277.7" "241.8" "304.2" "359.2" "256.7" "292.0" "226.5" "247.2" "706.4" "" "" "" "" "" "" "" "" "" "" "129.9" "154.0" "138.5" "140.1" "194.3" "142.8" "171.9" "123.6" "138.7" "706.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8095866348413873216" "False" "High" "IsMasterProtein" "Q8WUB8" "PHD finger protein 10 OS=Homo sapiens OX=9606 GN=PHF10 PE=1 SV=3" "0.000" "False" "4.011" "2" "1" "1" "1" "498" "56.0" "6.62" "3.15" "1" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00628" "55274" "ENSG00000130024" "PHF10" "hsa:55274; Q2YDA3; Q53HG8; Q8WUB8; Q9BXD2; Q9NV26" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8719462215085106760" "False" "High" "IsMasterProtein" "Q8N983" "Large ribosomal subunit protein mL43 OS=Homo sapiens OX=9606 GN=MRPL43 PE=1 SV=1" "0.000" "False" "3.998" "8" "2" "2" "2" "215" "23.4" "8.65" "5.09" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf05047" "84545" "ENSG00000055950" "MRPL43" "B1AL06; B1AL07; B1AL09; B1AL10; C9J5Q3; D3DR71; hsa:84545; Q5JW06; Q7Z719; Q7Z7H6; Q86XN1; Q8N983; Q9BYC7" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.015" "1.005" "0.944" "1.047" "1.044" "0.805" "0.762" "0.839" "1.474" "211.5" "214.6" "212.6" "199.6" "221.5" "220.7" "170.2" "161.2" "177.6" "311.7" "" "" "" "" "" "" "" "" "" "" "112.0" "119.0" "121.7" "91.9" "119.9" "122.8" "100.2" "88.0" "99.6" "311.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1419370867446709471" "False" "High" "IsMasterProtein" "P42677" "Small ribosomal subunit protein eS27 OS=Homo sapiens OX=9606 GN=RPS27 PE=1 SV=3" "0.000" "False" "3.997" "13" "1" "1" "1" "84" "9.5" "9.45" "3.32" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01667" "6232" "ENSG00000177954" "RPS27" "hsa:6232; P42677; Q5T4L6" "Cytoplasmic ribosomal proteins" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "25" "0" "1.035" "1.085" "1.050" "1.047" "1.123" "1.204" "1.193" "1.269" "1.481" "92.5" "95.7" "100.4" "97.1" "96.8" "103.9" "111.4" "110.4" "117.4" "137.0" "" "" "" "" "" "" "" "" "" "" "49.0" "53.1" "57.5" "44.7" "52.4" "57.8" "65.6" "60.2" "65.9" "137.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7060921209574590531" "False" "High" "IsMasterProtein" "Q01780" "Exosome complex component 10 OS=Homo sapiens OX=9606 GN=EXOSC10 PE=1 SV=2" "0.000" "False" "3.997" "2" "2" "2" "2" "885" "100.8" "8.46" "4.51" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00570, Pf01612, Pf08066" "5394" "ENSG00000171824" "EXOSC10" "B1AKQ0; B1AKQ1; hsa:5394; Q01780; Q15158" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "0.994" "0.884" "1.094" "0.955" "0.926" "0.954" "0.642" "1.074" "4.858" "94.4" "93.9" "83.4" "103.3" "90.2" "87.5" "90.1" "60.6" "101.4" "458.7" "" "" "" "" "" "" "" "" "" "" "50.0" "52.0" "47.8" "47.6" "48.8" "48.7" "53.0" "33.1" "56.9" "458.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5882151393090730100" "False" "High" "IsMasterProtein" "Q8TA86" "Retinitis pigmentosa 9 protein OS=Homo sapiens OX=9606 GN=RP9 PE=1 SV=2" "0.000" "False" "3.982" "4" "1" "1" "1" "221" "26.1" "9.79" "3.01" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "" "6100" "ENSG00000164610" "RP9" "hsa:6100; Q8TA86" "" "" "0" "0" "1.065" "1.166" "1.268" "1.112" "1.032" "1.162" "1.361" "1.214" "0.672" "134.5" "143.3" "156.7" "170.4" "149.6" "138.8" "156.2" "183.0" "163.2" "90.3" "" "" "" "" "" "" "" "" "" "" "71.2" "79.4" "89.8" "78.5" "80.9" "77.2" "91.9" "99.9" "91.6" "90.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9211390500631637896" "False" "High" "IsMasterProtein" "P04156" "Major prion protein OS=Homo sapiens OX=9606 GN=PRNP PE=1 SV=1" "0.000" "False" "3.974" "8" "2" "2" "2" "253" "27.6" "9.00" "2.26" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00377, Pf11587" "5621" "ENSG00000171867" "PRNP" "O60489; P04156; P78446; Q15216; Q15221; Q27H91; Q5QPB4; Q8TBG0; Q96E70; Q9UP19" "Complement system; Copper homeostasis; Prion disease pathway; Ferroptosis" "NCAM1 interactions; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "6" "0" "1.318" "1.175" "1.225" "1.144" "1.162" "1.251" "1.216" "1.207" "0.909" "185.0" "243.8" "217.4" "226.7" "211.7" "215.1" "231.5" "225.0" "223.4" "168.1" "" "" "" "" "" "" "" "" "" "" "98.0" "135.2" "124.5" "104.4" "114.5" "119.6" "136.2" "122.8" "125.3" "168.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2031700092780878303" "False" "High" "IsMasterProtein" "Q9Y5L4" "Mitochondrial import inner membrane translocase subunit Tim13 OS=Homo sapiens OX=9606 GN=TIMM13 PE=1 SV=1" "0.000" "False" "3.971" "11" "1" "1" "1" "95" "10.5" "8.18" "2.15" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf02953" "26517" "ENSG00000099800" "TIMM13" "hsa:26517; P62206; Q9UHL8; Q9WTL1; Q9Y5L4" "" "Mitochondrial protein import" "1" "0" "0.949" "0.842" "0.812" "0.885" "0.820" "0.777" "0.835" "1.131" "0.523" "297.0" "281.9" "250.0" "241.1" "263.0" "243.6" "230.8" "247.9" "336.0" "155.5" "" "" "" "" "" "" "" "" "" "" "157.3" "156.3" "143.2" "111.0" "142.3" "135.5" "135.8" "135.3" "188.5" "155.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5049084120360688973" "False" "High" "IsMasterProtein" "Q6PL24" "Protein TMED8 OS=Homo sapiens OX=9606 GN=TMED8 PE=1 SV=1" "0.000" "False" "3.970" "6" "1" "2" "1" "325" "35.7" "4.74" "1.69" "1" "" "" "" "Pf13897" "283578" "ENSG00000100580" "TMED8" "B3KTI6; hsa:283578; Q3MJB0; Q6PL24; Q9P1V9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5626279923656509616" "False" "High" "IsMasterProtein" "P25325" "3-mercaptopyruvate sulfurtransferase OS=Homo sapiens OX=9606 GN=MPST PE=1 SV=3" "0.000" "False" "3.967" "4" "1" "1" "1" "297" "33.2" "6.60" "3.25" "1" "other metabolic processes;developmental processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00581" "4357" "ENSG00000128309" "MPST" "A8MZ34; B3KP52; hsa:4357; J3KPV7; O75750; P25325; Q6FHN9" "Trans-sulfuration pathway; Amino acid metabolism" "Degradation of cysteine and homocysteine" "3" "0" "1.089" "0.879" "1.169" "1.235" "0.858" "1.307" "1.009" "0.964" "2.836" "38.5" "41.9" "33.9" "45.0" "47.6" "33.1" "50.3" "38.9" "37.1" "109.3" "" "" "" "" "" "" "" "" "" "" "20.4" "23.3" "19.4" "20.7" "25.7" "18.4" "29.6" "21.2" "20.8" "109.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6922732359213996073" "False" "High" "IsMasterProtein" "Q9H4L7" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 OS=Homo sapiens OX=9606 GN=SMARCAD1 PE=1 SV=2" "0.000" "False" "3.967" "1" "2" "2" "2" "1026" "117.3" "5.55" "5.41" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271" "56916" "ENSG00000163104" "SMARCAD1" "B7Z799; hsa:56916; Q05D56; Q96SX1; Q9H017; Q9H4L7; Q9H860; Q9NPU9; Q9ULU7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3276719871576654886" "False" "High" "IsMasterProtein" "Q92917" "G-patch domain and KOW motifs-containing protein OS=Homo sapiens OX=9606 GN=GPKOW PE=1 SV=2" "0.000" "False" "3.961" "4" "2" "3" "2" "476" "52.2" "6.15" "7.32" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00467, Pf12656" "27238" "ENSG00000068394; ENSG00000292204" "GPKOW" "hsa:27238; Q59EK5; Q92917; Q9BQA8" "" "mRNA Splicing - Major Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "556799029181218119" "False" "High" "IsMasterProtein" "Q13596" "Sorting nexin-1 OS=Homo sapiens OX=9606 GN=SNX1 PE=1 SV=3" "0.000" "False" "3.957" "2" "1" "1" "1" "522" "59.0" "5.15" "2.57" "1" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787, Pf03700, Pf09325" "6642" "ENSG00000028528" "SNX1" "A6NM19; A8K6T7; H0Y2M5; hsa:6642; O60750; O60751; Q13596; Q6ZRJ8" "" "" "0" "0" "1.182" "1.062" "1.317" "1.349" "1.146" "1.228" "0.851" "1.225" "2.338" "40.5" "47.9" "43.1" "53.4" "54.7" "46.5" "49.8" "34.5" "49.6" "94.8" "" "" "" "" "" "" "" "" "" "" "21.5" "26.6" "24.7" "24.6" "29.6" "25.8" "29.3" "18.8" "27.8" "94.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7550223946587707614" "False" "High" "IsMasterProtein" "Q13232" "Nucleoside diphosphate kinase 3 OS=Homo sapiens OX=9606 GN=NME3 PE=1 SV=2" "0.000" "False" "3.946" "6" "1" "1" "1" "169" "19.0" "7.84" "2.85" "1" "other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion" "kinase activity;other molecular function" "Pf00334" "4832" "ENSG00000103024" "NME3" "hsa:4832; Q13232; Q9BWH4" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4624493070796375817" "False" "High" "IsMasterProtein" "Q7Z7H8" "Large ribosomal subunit protein uL10m OS=Homo sapiens OX=9606 GN=MRPL10 PE=1 SV=3" "0.000" "False" "3.944" "4" "1" "1" "1" "261" "29.3" "9.58" "3.82" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00466" "124995" "ENSG00000159111" "MRPL10" "A6NGJ4; hsa:124995; Q7Z7H8; Q96B80; Q96Q55" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "504093738677667823" "False" "High" "IsMasterProtein" "O14867" "Transcription regulator protein BACH1 OS=Homo sapiens OX=9606 GN=BACH1 PE=1 SV=2" "0.000" "False" "3.942" "1" "1" "1" "1" "736" "81.9" "5.05" "3.43" "1" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00651, Pf03131" "571" "ENSG00000156273" "BACH1" "hsa:571; O14867; O43285; Q6ICU0" "Integrated cancer pathway; Ferroptosis" "Heme signaling; Regulation of HMOX1 expression and activity; Regulation of BACH1 activity; NFE2L2 regulating anti-oxidant/detoxification enzymes" "6" "0" "1.188" "0.948" "0.978" "1.144" "1.028" "1.354" "1.446" "1.286" "1.029" "58.2" "69.1" "55.1" "56.9" "66.6" "59.8" "78.8" "84.2" "74.8" "59.9" "" "" "" "" "" "" "" "" "" "" "30.8" "38.3" "31.6" "26.2" "36.0" "33.3" "46.4" "45.9" "42.0" "59.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3862869163996360692" "False" "High" "IsMasterProtein" "Q7LBR1" "Charged multivesicular body protein 1b OS=Homo sapiens OX=9606 GN=CHMP1B PE=1 SV=1" "0.000" "False" "3.940" "8" "2" "4" "2" "199" "22.1" "8.10" "10.46" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "57132" "ENSG00000255112" "CHMP1B" "hsa:57132; Q7LBR1; Q96E89; Q9HD41" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5531669477434534246" "False" "High" "IsMasterProtein" "Q9NX01" "Thioredoxin-like protein 4B OS=Homo sapiens OX=9606 GN=TXNL4B PE=1 SV=1" "0.000" "False" "3.936" "10" "2" "3" "2" "149" "17.0" "6.00" "5.94" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "" "Pf02966" "54957" "ENSG00000140830" "TXNL4B" "D3DWS6; hsa:54957; Q9NX01" "" "" "0" "0" "1.546" "1.217" "1.101" "1.481" "1.303" "1.197" "1.181" "1.495" "1.659" "14.0" "21.7" "17.1" "15.5" "20.8" "18.3" "16.8" "16.6" "21.0" "23.3" "" "" "" "" "" "" "" "" "" "" "7.4" "12.0" "9.8" "7.1" "11.3" "10.2" "9.9" "9.1" "11.8" "23.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5305679341133587567" "False" "High" "IsMasterProtein" "Q86WR0" "Coiled-coil domain-containing protein 25 OS=Homo sapiens OX=9606 GN=CCDC25 PE=1 SV=2" "0.000" "False" "3.901" "4" "1" "1" "1" "208" "24.5" "6.80" "2.68" "1" "other biological processes" "plasma membrane;other membranes;other cell component" "nucleic acid binding activity" "Pf05670" "55246" "ENSG00000147419" "CCDC25" "hsa:55246; Q0P663; Q86WR0; Q96SI2; Q9NV98" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2137073451658822686" "False" "High" "IsMasterProtein" "Q01664" "Transcription factor AP-4 OS=Homo sapiens OX=9606 GN=TFAP4 PE=1 SV=2" "0.000" "False" "3.891" "2" "1" "2" "1" "338" "38.7" "5.87" "5.57" "1" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "7023" "ENSG00000090447" "TFAP4" "hsa:7023; O60409; Q01664" "DYRK1A involvement regarding cell proliferation in brain development" "" "1" "0" "1.081" "0.997" "1.101" "1.223" "0.995" "1.062" "0.930" "0.899" "2.560" "189.2" "204.5" "188.7" "208.4" "231.5" "188.3" "200.9" "176.0" "170.0" "484.5" "" "" "" "" "" "" "" "" "" "" "100.2" "113.4" "108.1" "96.0" "125.3" "104.7" "118.3" "96.0" "95.4" "484.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4446297038364687966" "False" "High" "IsMasterProtein" "Q9NPA8" "Transcription and mRNA export factor ENY2 OS=Homo sapiens OX=9606 GN=ENY2 PE=1 SV=1" "0.000" "False" "3.891" "15" "2" "3" "2" "101" "11.5" "9.33" "7.93" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf10163" "56943" "ENSG00000120533" "ENY2" "B2RE52; G3V117; hsa:56943; Q9NPA8" "" "HATs acetylate histones" "1" "0" "1.118" "1.154" "1.043" "1.071" "0.975" "1.008" "1.220" "1.144" "0.649" "287.2" "320.9" "331.4" "299.5" "307.7" "279.9" "289.4" "350.5" "328.6" "186.3" "" "" "" "" "" "" "" "" "" "" "152.1" "177.9" "189.8" "137.9" "166.5" "155.7" "170.3" "191.3" "184.3" "186.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6484824469682462574" "False" "High" "IsMasterProtein" "Q17R31" "Putative deoxyribonuclease TATDN3 OS=Homo sapiens OX=9606 GN=TATDN3 PE=1 SV=1" "0.000" "False" "3.890" "3" "1" "1" "1" "274" "30.3" "7.15" "3.27" "1" "" "nucleus" "other molecular function" "Pf01026" "128387" "ENSG00000203705" "TATDN3" "A6NGS3; B7Z1C1; B7Z978; B7ZLQ6; E9PJE5; E9PNH3; G3V151; hsa:128387; Q17R31; Q4G0L1" "" "" "0" "0" "1.048" "1.091" "0.989" "1.142" "1.077" "1.164" "0.917" "0.978" "0.594" "183.4" "192.2" "200.1" "181.4" "209.4" "197.5" "213.6" "168.2" "179.5" "109.0" "" "" "" "" "" "" "" "" "" "" "97.1" "106.6" "114.6" "83.5" "113.3" "109.9" "125.7" "91.8" "100.7" "109.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3764850706603646464" "False" "High" "IsMasterProtein" "Q9ULC4" "Malignant T-cell-amplified sequence 1 OS=Homo sapiens OX=9606 GN=MCTS1 PE=1 SV=1" "0.000" "False" "3.890" "5" "1" "3" "1" "181" "20.5" "8.82" "8.82" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other cell component" "nucleic acid binding activity" "Pf01472, Pf17832" "28985" "ENSG00000232119" "MCTS1" "B4DGY2; hsa:28985; Q502X6; Q9ULC4" "" "" "0" "0" "1.103" "1.009" "0.896" "1.018" "1.121" "0.996" "0.999" "1.052" "0.846" "457.3" "504.6" "461.3" "409.8" "465.8" "512.7" "455.4" "456.7" "480.9" "386.8" "" "" "" "" "" "" "" "" "" "" "242.2" "279.8" "264.2" "188.7" "252.0" "285.2" "268.0" "249.3" "269.8" "386.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1879771635680972276" "False" "High" "IsMasterProtein" "O95208" "Epsin-2 OS=Homo sapiens OX=9606 GN=EPN2 PE=1 SV=3" "0.000" "False" "3.888" "1" "1" "2" "1" "641" "68.4" "7.52" "6.59" "1" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01417" "22905" "ENSG00000072134" "EPN2" "A8MTV8; B3KRX8; E9PBC2; hsa:22905; O95207; O95208; Q52LD0; Q9H7Z2; Q9UPT7" "" "Cargo recognition for clathrin-mediated endocytosis" "2" "0" "0.880" "1.019" "0.991" "1.087" "1.029" "0.916" "0.985" "1.058" "0.623" "255.3" "224.6" "260.1" "252.9" "277.4" "262.6" "233.9" "251.5" "270.0" "159.0" "" "" "" "" "" "" "" "" "" "" "135.2" "124.5" "148.9" "116.5" "150.1" "146.1" "137.7" "137.3" "151.4" "159.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2898221823971910502" "False" "High" "IsMasterProtein" "Q96H79" "Zinc finger CCCH-type antiviral protein 1-like OS=Homo sapiens OX=9606 GN=ZC3HAV1L PE=1 SV=2" "0.000" "False" "3.885" "3" "1" "1" "1" "300" "32.9" "8.13" "2.87" "1" "" "cytosol" "" "Pf18606" "92092" "ENSG00000146858" "ZC3HAV1L" "hsa:92092; Q8WUD9; Q96H79" "" "" "0" "0" "0.957" "1.292" "1.342" "1.252" "1.179" "1.252" "0.946" "1.297" "2.053" "45.6" "43.6" "58.9" "61.1" "57.1" "53.7" "57.1" "43.1" "59.1" "93.5" "" "" "" "" "" "" "" "" "" "" "24.1" "24.2" "33.7" "28.2" "30.9" "29.9" "33.6" "23.5" "33.1" "93.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4618404774181820652" "False" "High" "IsMasterProtein" "P57076" "Cilia- and flagella-associated protein 298 OS=Homo sapiens OX=9606 GN=CFAP298 PE=1 SV=1" "0.000" "False" "3.885" "5" "1" "1" "1" "290" "33.2" "7.44" "3.19" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "Pf11069" "56683" "ENSG00000159079" "CFAP298" "hsa:56683; P57076; Q53FH0" "Ciliopathies" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3813921513967771332" "False" "High" "IsMasterProtein" "P51825" "AF4/FMR2 family member 1 OS=Homo sapiens OX=9606 GN=AFF1 PE=1 SV=1" "0.000" "False" "3.881" "1" "2" "2" "2" "1210" "131.3" "9.20" "4.17" "2" "other biological processes" "nucleus" "" "Pf05110, Pf18875, Pf18876" "4299" "ENSG00000172493" "AFF1" "B4DTU1; E9PBM3; hsa:4299; P51825" "" "" "0" "0" "1.381" "1.459" "1.497" "1.259" "1.318" "1.324" "1.464" "1.400" "1.431" "25.9" "35.7" "37.8" "38.7" "32.6" "34.1" "34.3" "37.9" "36.2" "37.1" "" "" "" "" "" "" "" "" "" "" "13.7" "19.8" "21.6" "17.8" "17.6" "19.0" "20.2" "20.7" "20.3" "37.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5518628090009250384" "False" "High" "IsMasterProtein" "Q3V6T2" "Girdin OS=Homo sapiens OX=9606 GN=CCDC88A PE=1 SV=2" "0.000" "False" "3.881" "1" "2" "2" "2" "1871" "215.9" "6.21" "2.92" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf19047" "55704" "ENSG00000115355" "CCDC88A" "A1IGE7; B7ZM78; C9JG83; hsa:55704; Q3V6T2; Q53SF1; Q581G3; Q5HYD0; Q7Z339; Q7Z3C5" "Mesodermal commitment pathway" "RND3 GTPase cycle; RND1 GTPase cycle" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-366099160936262297" "False" "High" "IsMasterProtein" "Q9NQG5" "Regulation of nuclear pre-mRNA domain-containing protein 1B OS=Homo sapiens OX=9606 GN=RPRD1B PE=1 SV=1" "0.000" "False" "3.874" "2" "1" "1" "1" "326" "36.9" "5.97" "3.25" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04818, Pf16566" "58490" "ENSG00000101413" "RPRD1B" "hsa:58490; Q1WDE7; Q6PKF4; Q9NQG5" "Modulators of TCR signaling and T cell activation" "RNA polymerase II transcribes snRNA genes" "2" "0" "1.151" "1.043" "0.990" "1.084" "1.000" "1.133" "1.027" "1.154" "3.676" "108.8" "125.2" "113.4" "107.6" "117.9" "108.8" "123.2" "111.7" "125.6" "399.8" "" "" "" "" "" "" "" "" "" "" "57.6" "69.4" "65.0" "49.6" "63.8" "60.5" "72.5" "61.0" "70.4" "399.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7489520263377738348" "False" "High" "IsMasterProtein" "Q96DI7" "U5 small nuclear ribonucleoprotein 40 kDa protein OS=Homo sapiens OX=9606 GN=SNRNP40 PE=1 SV=1" "0.000" "False" "3.871" "8" "2" "2" "2" "357" "39.3" "8.10" "3.14" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf00400" "9410" "ENSG00000060688" "SNRNP40" "B4DQJ1; hsa:9410; O75938; O95320; Q96DI7" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5641519450922138293" "False" "High" "IsMasterProtein" "P15954" "Cytochrome c oxidase subunit 7C, mitochondrial OS=Homo sapiens OX=9606 GN=COX7C PE=1 SV=1" "0.000" "False" "3.869" "14" "1" "1" "1" "63" "7.2" "10.27" "2.94" "1" "other metabolic processes" "other membranes;mitochondrion" "" "Pf02935" "1350" "ENSG00000127184" "COX7C" "hsa:1350; P15954; Q6NR81" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "7" "0" "0.977" "1.080" "0.983" "0.841" "1.074" "0.832" "1.042" "0.969" "0.785" "87.9" "85.9" "94.9" "86.4" "73.9" "94.4" "73.1" "91.6" "85.2" "69.0" "" "" "" "" "" "" "" "" "" "" "46.5" "47.6" "54.3" "39.8" "40.0" "52.5" "43.0" "50.0" "47.8" "69.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-180619704287479053" "False" "High" "IsMasterProtein" "P01137" "Transforming growth factor beta-1 proprotein OS=Homo sapiens OX=9606 GN=TGFB1 PE=1 SV=3" "0.000" "False" "3.865" "5" "2" "2" "2" "390" "44.3" "8.53" "1.76" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00019, Pf00688" "7040" "ENSG00000105329" "TGFB1" "A8K792; hsa:7040; P01137; Q9UCG4" "MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Cell cycle; Allograft rejection; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Cardiac progenitor differentiation; Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Cardiac hypertrophic response; Mammary gland development pathway - Embryonic development (Stage 1 of 4); Pluripotent stem cell differentiation pathway; Endoderm differentiation; Dopaminergic neurogenesis; IL-3 signaling pathway; Extracellular vesicle-mediated signaling in recipient cells; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Lung fibrosis; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Interactions between LOXL4 and oxidative stress pathway; MAPK signaling pathway; Canonical and non-canonical TGF-B signaling; Clear cell renal cell carcinoma pathways; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Type 2 papillary renal cell carcinoma; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Neovascularization processes; Nonalcoholic fatty liver disease; Platelet-mediated interactions with vascular and circulating cells; Control of immune tolerance by vasoactive intestinal peptide; Selective expression of chemokine receptors during T-cell polarization; Signal transduction through IL1R; Envelope proteins and their potential roles in EDMD physiopathology; Interactions between immune cells and microRNAs in tumor microenvironment; Hepatitis B infection; Endochondral ossification; Endochondral ossification with skeletal dysplasias; TGF-beta receptor signaling in skeletal dysplasias; Regucalcin in proximal tubule epithelial kidney cells; Overlap between signal transduction pathways contributing to LMNA laminopathies; 3q29 copy number variation syndrome; Angiotensin II receptor type 1 pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; T cell modulation in pancreatic cancer; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Complement system in neuronal development and plasticity; Overview of proinflammatory and profibrotic mediators; CCL18 signaling pathway; Progeria-associated lipodystrophy; Th17 cell differentiation pathway; Urotensin-II-mediated signaling pathway; Ulcerative colitis signaling; Inflammatory bowel disease signaling; Clock-controlled autophagy in bone metabolism; Markers of kidney cell lineage; Comprehensive IL-17A signaling; Cell interactions of the pancreatic cancer microenvironment; Immune infiltration in pancreatic cancer; Cytokines and inflammatory response; 1p36 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; Affected pathways in Duchenne muscular dystrophy; IL-19 signaling pathway; ACE inhibitor pathway; TGF-beta receptor signaling; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "Cell surface interactions at the vascular wall; Transcriptional regulation of white adipocyte differentiation; UCH proteinases; ECM proteoglycans; Platelet degranulation ; Regulation of RUNX3 expression and activity; Interleukin-4 and Interleukin-13 signaling; Syndecan interactions; Downregulation of TGF-beta receptor signaling; Molecules associated with elastic fibres; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; RUNX3 regulates p14-ARF; Influenza Virus Induced Apoptosis; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); TGFBR2 MSI Frameshift Mutants in Cancer; TGFBR2 Kinase Domain Mutants in Cancer; TGFBR1 LBD Mutants in Cancer; RUNX3 regulates CDKN1A transcription" "95" "0" "0.982" "0.941" "1.131" "0.820" "0.918" "1.299" "1.085" "1.148" "0.929" "28.7" "28.2" "27.0" "32.4" "23.5" "26.3" "37.3" "31.1" "32.9" "26.7" "" "" "" "" "" "" "" "" "" "" "15.2" "15.6" "15.5" "14.9" "12.7" "14.7" "21.9" "17.0" "18.5" "26.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3000409602916512702" "False" "High" "IsMasterProtein" "O15357" "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 OS=Homo sapiens OX=9606 GN=INPPL1 PE=1 SV=2" "0.000" "False" "3.863" "1" "2" "2" "1" "1258" "138.5" "6.54" "2.38" "2" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00017, Pf00536" "3636" "ENSG00000165458" "INPPL1" "B2RTX5; hsa:3636; O15357; Q13577; Q13578" "EGF/EGFR signaling pathway; Insulin signaling" "Synthesis of PIPs at the plasma membrane; Interleukin receptor SHC signaling; Synthesis of IP3 and IP4 in the cytosol; Signaling by CSF1 (M-CSF) in myeloid cells" "6" "0" "0.897" "1.049" "1.111" "0.886" "1.038" "0.965" "0.776" "1.001" "4.229" "133.1" "119.3" "139.6" "147.8" "117.9" "138.2" "128.4" "103.2" "133.2" "562.7" "" "" "" "" "" "" "" "" "" "" "70.5" "66.2" "80.0" "68.1" "63.8" "76.9" "75.6" "56.3" "74.7" "562.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8214160649428381093" "False" "High" "IsMasterProtein" "P22415" "Upstream stimulatory factor 1 OS=Homo sapiens OX=9606 GN=USF1 PE=1 SV=1" "0.000" "False" "3.860" "5" "2" "2" "1" "310" "33.5" "5.54" "4.93" "2" "stress response;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "7391" "ENSG00000158773" "USF1" "B2RBZ4; hsa:7391; P22415; Q5SY46; Q7Z5Y1" "7q11.23 copy number variation syndrome; Familial hyperlipidemia type 2" "Estrogen-dependent gene expression" "3" "0" "1.071" "0.896" "1.163" "0.962" "0.920" "1.049" "1.019" "1.073" "1.396" "263.9" "282.7" "236.4" "306.9" "253.8" "242.8" "276.9" "268.8" "283.2" "368.4" "" "" "" "" "" "" "" "" "" "" "139.7" "156.7" "135.4" "141.3" "137.3" "135.0" "163.0" "146.7" "158.9" "368.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1396372760161625634" "False" "High" "IsMasterProtein" "Q8N129" "Protein canopy homolog 4 OS=Homo sapiens OX=9606 GN=CNPY4 PE=1 SV=1" "0.000" "False" "3.853" "5" "1" "1" "1" "248" "28.3" "4.64" "3.19" "1" "other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding" "Pf11938" "245812" "ENSG00000166997" "CNPY4" "hsa:245812; Q8N129; Q8WUN9" "" "" "0" "0" "0.978" "1.189" "1.076" "1.271" "1.017" "1.172" "1.493" "1.093" "0.929" "33.9" "33.2" "40.3" "36.5" "43.1" "34.5" "39.7" "50.6" "37.1" "31.5" "" "" "" "" "" "" "" "" "" "" "18.0" "18.4" "23.1" "16.8" "23.3" "19.2" "23.4" "27.6" "20.8" "31.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3376743551660886452" "False" "High" "IsMasterProtein" "Q8N5L8" "Ribonuclease P protein subunit p25-like protein OS=Homo sapiens OX=9606 GN=RPP25L PE=1 SV=1" "0.000" "False" "3.851" "6" "1" "1" "1" "163" "17.6" "10.30" "3.40" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf01918" "138716" "ENSG00000164967" "RPP25L" "D3DRM5; hsa:138716; Q8N5L8" "" "" "0" "0" "1.112" "0.993" "1.087" "1.105" "1.096" "1.096" "1.212" "1.106" "0.798" "118.8" "132.1" "118.0" "129.1" "131.2" "130.2" "130.2" "144.0" "131.4" "94.8" "" "" "" "" "" "" "" "" "" "" "62.9" "73.2" "67.6" "59.5" "71.0" "72.4" "76.6" "78.6" "73.7" "94.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8115574768027660471" "False" "High" "IsMasterProtein" "P30837" "Aldehyde dehydrogenase X, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH1B1 PE=1 SV=4" "0.000" "False" "3.850" "2" "1" "2" "1" "517" "57.2" "6.99" "6.05" "1" "other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00171" "219" "ENSG00000137124" "ALDH1B1" "B2R8F0; hsa:219; P30837; Q8WX76; Q9BV45" "" "Mitochondrial protein degradation; Ethanol oxidation" "2" "0" "0.959" "0.993" "0.934" "0.962" "0.872" "0.806" "0.871" "0.823" "0.676" "394.8" "378.4" "392.0" "368.9" "379.6" "344.4" "318.2" "343.8" "325.0" "266.8" "" "" "" "" "" "" "" "" "" "" "209.0" "209.8" "224.5" "169.9" "205.4" "191.6" "187.3" "187.7" "182.3" "266.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4415250102849728185" "False" "High" "IsMasterProtein" "Q76FK4" "Nucleolar protein 8 OS=Homo sapiens OX=9606 GN=NOL8 PE=1 SV=1" "0.000" "False" "3.840" "1" "1" "1" "1" "1167" "131.5" "7.09" "3.48" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00076" "55035" "ENSG00000198000; ENSG00000291347" "NOL8" "hsa:55035; Q5TCC7; Q5TCC8; Q5TCD3; Q5TCD5; Q5TCD6; Q5TCD7; Q76D35; Q76FK4; Q7L3E2; Q9H586; Q9H795; Q9H7W7; Q9H9J6; Q9NWA4; Q9NWM4" "" "" "0" "0" "0.959" "0.982" "1.234" "1.259" "0.965" "2.356" "2.576" "2.426" "0.697" "117.0" "112.2" "114.9" "144.3" "147.3" "112.9" "275.6" "301.4" "283.9" "81.5" "" "" "" "" "" "" "" "" "" "" "61.9" "62.2" "65.8" "66.5" "79.7" "62.8" "162.2" "164.5" "159.3" "81.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3003909500726814877" "False" "High" "IsMasterProtein" "O60443" "Gasdermin-E OS=Homo sapiens OX=9606 GN=GSDME PE=1 SV=2" "0.000" "False" "3.839" "4" "2" "2" "2" "496" "54.5" "5.17" "5.07" "2" "transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "transporter activity;other molecular function" "Pf04598, Pf17708" "1687" "ENSG00000105928" "GSDME" "A4D156; B2RAX9; B3KT05; O14590; O60443; Q08AQ8; Q9UBV3" "" "Regulation of TLR by endogenous ligand; Release of apoptotic factors from the mitochondria; Pyroptosis; Defective pyroptosis" "4" "0" "0.938" "0.982" "1.061" "1.012" "0.874" "1.032" "0.896" "0.910" "0.829" "122.0" "114.4" "119.8" "129.4" "123.5" "106.6" "125.9" "109.4" "111.1" "101.1" "" "" "" "" "" "" "" "" "" "" "64.6" "63.4" "68.6" "59.6" "66.8" "59.3" "74.1" "59.7" "62.3" "101.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "908398624639479548" "False" "High" "IsMasterProtein" "P62913" "Large ribosomal subunit protein uL5 OS=Homo sapiens OX=9606 GN=RPL11 PE=1 SV=2" "0.000" "False" "3.835" "9" "2" "2" "2" "178" "20.2" "9.60" "4.91" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00281, Pf00673" "6135" "ENSG00000142676" "RPL11" "hsa:6135; P25121; P39026; P62913; Q8TDH2; Q9Y674" "MET in type 1 papillary renal cell carcinoma; Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Response of EIF2AK4 (GCN2) to amino acid deficiency; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "0.991" "1.005" "1.320" "1.152" "1.259" "1.101" "1.126" "1.206" "1.581" "250.4" "248.2" "251.7" "330.5" "288.5" "315.3" "275.8" "282.1" "302.1" "396.0" "" "" "" "" "" "" "" "" "" "" "132.6" "137.6" "144.1" "152.2" "156.1" "175.4" "162.3" "154.0" "169.5" "396.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7506213950327089282" "False" "High" "IsMasterProtein" "Q8IUF8" "Ribosomal oxygenase 2 OS=Homo sapiens OX=9606 GN=RIOX2 PE=1 SV=1" "0.000" "False" "3.815" "3" "2" "2" "2" "465" "52.8" "6.70" "5.32" "2" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08007, Pf20514" "84864" "ENSG00000170854" "RIOX2" "D3DN35; Q6AHW4; Q6SKS0; Q8IU69; Q8IUF6; Q8IUF7; Q8IUF8; Q96C17; Q96KB0" "" "Protein hydroxylation; HDMs demethylate histones" "2" "0" "0.956" "0.919" "1.008" "1.019" "1.020" "1.079" "0.849" "1.021" "1.657" "353.6" "338.0" "324.9" "356.3" "360.2" "360.8" "381.4" "300.2" "360.9" "585.9" "" "" "" "" "" "" "" "" "" "" "187.2" "187.4" "186.1" "164.1" "194.9" "200.7" "224.5" "163.9" "202.5" "585.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1706468280429092974" "False" "High" "IsMasterProtein" "Q9Y3S2" "Zinc finger protein 330 OS=Homo sapiens OX=9606 GN=ZNF330 PE=1 SV=1" "0.000" "False" "3.808" "5" "2" "2" "2" "320" "36.2" "6.16" "2.20" "2" "" "nucleus;other cell component" "other molecular function" "Pf06524" "27309" "ENSG00000109445" "ZNF330" "B2RDA3; hsa:27309; Q9Y3S2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6273876737902892662" "False" "High" "IsMasterProtein" "P83876" "Thioredoxin-like protein 4A OS=Homo sapiens OX=9606 GN=TXNL4A PE=1 SV=1" "0.000" "False" "3.805" "8" "1" "1" "1" "142" "16.8" "5.85" "2.30" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf02966" "10907" "ENSG00000141759" "TXNL4A" "B2RC18; hsa:10907; O14834; P83876" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3102131592095934236" "False" "High" "IsMasterProtein" "Q969G6" "Riboflavin kinase OS=Homo sapiens OX=9606 GN=RFK PE=1 SV=2" "0.000" "False" "3.804" "6" "1" "2" "1" "155" "17.6" "8.13" "5.26" "1" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "kinase activity;other molecular function" "Pf01687" "55312" "ENSG00000135002" "RFK" "hsa:55312; Q5JSG9; Q969G6; Q9NUT7" "Selenium micronutrient network; Folate metabolism; TNF-alpha signaling pathway" "Vitamin B2 (riboflavin) metabolism" "4" "0" "0.967" "1.114" "1.072" "1.043" "1.042" "0.940" "0.882" "0.910" "0.876" "265.9" "257.2" "296.2" "285.1" "277.4" "277.1" "250.0" "234.6" "241.9" "233.0" "" "" "" "" "" "" "" "" "" "" "140.8" "142.6" "169.7" "131.3" "150.1" "154.1" "147.1" "128.1" "135.7" "233.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6030770174415932169" "False" "High" "IsMasterProtein" "P52294" "Importin subunit alpha-5 OS=Homo sapiens OX=9606 GN=KPNA1 PE=1 SV=3" "0.000" "False" "3.803" "3" "2" "2" "2" "538" "60.2" "5.01" "2.60" "2" "cell-cell signaling;cell cycle OR cell proliferation;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3836" "ENSG00000114030" "KPNA1" "D3DN93; hsa:3836; P52294; Q6IBQ9; Q9BQ56" "Ebola virus infection in host" "Apoptosis induced DNA fragmentation; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Vpr-mediated nuclear import of PICs; Interferon alpha/beta signaling; Assembly of the ORC complex at the origin of replication; Integration of provirus; Inhibition of nitric oxide production" "10" "0" "0.984" "0.970" "1.444" "1.195" "0.968" "2.084" "1.981" "1.747" "1.779" "75.9" "74.7" "73.6" "109.5" "90.6" "73.5" "158.1" "150.2" "132.5" "135.0" "" "" "" "" "" "" "" "" "" "" "40.2" "41.4" "42.2" "50.5" "49.0" "40.9" "93.0" "82.0" "74.3" "135.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6179011071974481602" "False" "High" "IsMasterProtein" "Q9NWS0" "PIH1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PIH1D1 PE=1 SV=1" "0.000" "False" "3.801" "5" "1" "1" "1" "290" "32.3" "5.14" "2.82" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf08190, Pf18201" "55011" "ENSG00000104872" "PIH1D1" "B4DGN7; B4E2X7; hsa:55011; Q9BVL0; Q9NWS0" "" "" "0" "0" "0.876" "0.829" "1.101" "1.127" "0.924" "1.002" "0.772" "1.046" "2.943" "41.8" "36.6" "34.6" "46.0" "47.1" "38.6" "41.8" "32.2" "43.7" "122.9" "" "" "" "" "" "" "" "" "" "" "22.1" "20.3" "19.8" "21.2" "25.5" "21.5" "24.6" "17.6" "24.5" "122.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2825155014730555615" "False" "High" "IsMasterProtein" "Q6GMV2" "Histone-lysine N-trimethyltransferase SMYD5 OS=Homo sapiens OX=9606 GN=SMYD5 PE=1 SV=2" "0.000" "False" "3.789" "2" "1" "3" "1" "418" "47.3" "5.05" "7.67" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "" "other molecular function" "Pf00856" "10322" "ENSG00000135632" "SMYD5" "D6W5H3; hsa:10322; Q13558; Q6GMV2" "Histone modifications" "" "1" "0" "1.169" "1.016" "1.382" "1.097" "1.162" "1.303" "1.546" "1.179" "0.617" "49.2" "57.5" "50.0" "67.9" "53.9" "57.1" "64.0" "76.0" "58.0" "30.3" "" "" "" "" "" "" "" "" "" "" "26.0" "31.9" "28.6" "31.3" "29.2" "31.8" "37.7" "41.5" "32.5" "30.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7656229856008546485" "False" "High" "IsMasterProtein" "O95453" "Poly(A)-specific ribonuclease PARN OS=Homo sapiens OX=9606 GN=PARN PE=1 SV=1" "0.000" "False" "3.788" "3" "2" "2" "2" "639" "73.4" "6.20" "5.26" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04857, Pf08675" "5073" "ENSG00000140694; ENSG00000274829" "PARN" "B2RCB3; B4DDG8; B4DSB0; B4DWR4; B4E1H6; hsa:5073; O95453" "Lung fibrosis" "Deadenylation of mRNA; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA" "4" "0" "0.973" "1.103" "1.239" "1.009" "1.134" "1.256" "1.082" "1.195" "2.339" "145.1" "141.1" "160.0" "179.7" "146.3" "164.5" "182.3" "157.0" "173.4" "339.4" "" "" "" "" "" "" "" "" "" "" "76.8" "78.2" "91.6" "82.8" "79.2" "91.5" "107.3" "85.7" "97.3" "339.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3162421235115001887" "False" "High" "IsMasterProtein" "L0R819" "ASNSD1 upstream open reading frame protein OS=Homo sapiens OX=9606 GN=ASDURF PE=1 SV=1" "0.000" "False" "3.786" "21" "1" "1" "1" "96" "11.2" "8.88" "4.33" "1" "other biological processes" "other cell component" "" "" "" "ENSG00000286053" "ASDURF" "L0R819" "" "" "0" "0" "0.935" "1.108" "1.281" "1.200" "1.269" "1.059" "1.048" "1.187" "1.394" "82.3" "76.9" "91.2" "105.4" "98.7" "104.4" "87.1" "86.2" "97.6" "114.7" "" "" "" "" "" "" "" "" "" "" "43.6" "42.7" "52.2" "48.5" "53.4" "58.1" "51.3" "47.1" "54.8" "114.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3678214923131327318" "False" "High" "IsMasterProtein" "Q96RQ3" "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=MCCC1 PE=1 SV=3" "0.000" "False" "3.783" "2" "1" "1" "1" "725" "80.4" "7.78" "2.97" "1" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00289, Pf00364, Pf02785, Pf02786" "56922" "ENSG00000078070" "MCCC1" "hsa:56922; Q59ES4; Q96RQ3; Q9H959; Q9NS97" "Amino acid metabolism" "Branched-chain amino acid catabolism; Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency" "4" "0" "0.944" "0.929" "0.995" "0.988" "1.080" "1.004" "1.043" "0.937" "0.680" "162.2" "153.1" "150.7" "161.4" "160.3" "175.2" "162.8" "169.2" "152.0" "110.2" "" "" "" "" "" "" "" "" "" "" "85.9" "84.9" "86.3" "74.3" "86.7" "97.4" "95.8" "92.4" "85.3" "110.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7042305927855089094" "False" "High" "IsMasterProtein" "Q96E09" "PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 OS=Homo sapiens OX=9606 GN=PABIR1 PE=1 SV=1" "0.000" "False" "3.779" "5" "1" "1" "1" "287" "30.5" "6.79" "4.37" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "nucleus;other cell component" "enzyme regulator activity" "" "116224" "ENSG00000187866" "PABIR1" "hsa:116224; Q96E09" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2087285006199939008" "False" "High" "IsMasterProtein" "P61626" "Lysozyme C OS=Homo sapiens OX=9606 GN=LYZ PE=1 SV=1" "0.000" "False" "3.774" "6" "1" "1" "1" "148" "16.5" "9.16" "3.47" "1" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00062" "4069" "ENSG00000090382" "LYZ" "hsa:4069; P00695; P61626; Q13170; Q9UCF8" "Macrophage markers; Pancreatic cancer subtypes" "Neutrophil degranulation; Amyloid fiber formation; Antimicrobial peptides" "5" "0" "0.951" "0.829" "0.819" "1.026" "1.020" "0.871" "0.945" "1.087" "0.608" "157.7" "150.0" "130.8" "129.3" "161.9" "160.9" "137.4" "149.1" "171.5" "95.9" "" "" "" "" "" "" "" "" "" "" "83.5" "83.1" "74.9" "59.5" "87.6" "89.5" "80.9" "81.4" "96.2" "95.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7569413463716614588" "False" "High" "IsMasterProtein" "Q8N6M0" "Deubiquitinase OTUD6B OS=Homo sapiens OX=9606 GN=OTUD6B PE=1 SV=1" "0.000" "False" "3.772" "6" "2" "2" "2" "293" "33.8" "6.05" "2.88" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "" "other molecular function" "Pf02338" "51633" "ENSG00000155100" "OTUD6B" "A8K6I1; B4DEY0; hsa:51633; Q8N6M0; Q9NTA4; Q9Y387" "Warburg effect modulated by deubiquitinating enzymes and their substrates" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6707241685728679125" "False" "High" "IsMasterProtein" "Q9NY93" "Probable ATP-dependent RNA helicase DDX56 OS=Homo sapiens OX=9606 GN=DDX56 PE=1 SV=1" "0.000" "False" "3.771" "2" "1" "1" "1" "547" "61.6" "9.26" "3.58" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "54606" "ENSG00000136271" "DDX56" "A4D2K9; C9JV95; hsa:54606; Q6IAE2; Q9H9I8; Q9NY93" "" "" "0" "0" "1.067" "0.868" "1.026" "0.878" "0.954" "0.878" "0.790" "0.819" "1.480" "99.8" "106.5" "86.6" "102.4" "87.6" "95.1" "87.6" "78.9" "81.7" "147.7" "" "" "" "" "" "" "" "" "" "" "52.8" "59.0" "49.6" "47.2" "47.4" "52.9" "51.5" "43.0" "45.8" "147.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1987024820899376297" "False" "High" "IsMasterProtein" "Q9BRA2" "Thioredoxin domain-containing protein 17 OS=Homo sapiens OX=9606 GN=TXNDC17 PE=1 SV=1" "0.000" "False" "3.769" "14" "2" "4" "2" "123" "13.9" "5.52" "6.73" "2" "signal transduction;other biological processes" "cytosol" "other molecular function" "Pf06110" "84817" "ENSG00000129235" "TXNDC17" "A8K7E8; hsa:84817; Q9BRA2" "" "" "0" "0" "0.835" "1.172" "0.902" "0.944" "0.893" "0.893" "0.992" "0.905" "0.740" "69.8" "58.3" "81.8" "63.0" "65.9" "62.4" "62.3" "69.2" "63.2" "51.7" "" "" "" "" "" "" "" "" "" "" "37.0" "32.3" "46.9" "29.0" "35.7" "34.7" "36.7" "37.8" "35.5" "51.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8048887560610190463" "False" "High" "IsMasterProtein" "Q5JPH6" "Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial OS=Homo sapiens OX=9606 GN=EARS2 PE=1 SV=2" "0.000" "False" "3.757" "2" "1" "1" "1" "523" "58.7" "8.76" "2.77" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00749, Pf19269" "124454" "ENSG00000103356" "EARS2" "B3KTT2; D3DWF1; hsa:124454; Q5JPH6; Q86YH3; Q8TF31" "" "Mitochondrial tRNA aminoacylation" "1" "0" "1.240" "1.062" "1.258" "1.079" "1.070" "1.169" "0.847" "1.072" "5.129" "47.4" "58.7" "50.3" "59.6" "51.1" "50.7" "55.3" "40.1" "50.8" "242.9" "" "" "" "" "" "" "" "" "" "" "25.1" "32.6" "28.8" "27.4" "27.6" "28.2" "32.6" "21.9" "28.5" "242.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5634766023329637374" "False" "High" "IsMasterProtein" "Q9HAF1" "Chromatin modification-related protein MEAF6 OS=Homo sapiens OX=9606 GN=MEAF6 PE=1 SV=1" "0.000" "False" "3.757" "9" "2" "2" "2" "191" "21.6" "9.32" "5.61" "2" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf09340" "64769" "ENSG00000163875" "MEAF6" "B1AK64; hsa:64769; Q4F967; Q7Z311; Q86WE3; Q9HAF1" "" "HATs acetylate histones; Regulation of TP53 Activity through Acetylation" "2" "0" "0.989" "1.160" "1.157" "1.121" "1.126" "1.213" "1.435" "1.376" "0.861" "273.7" "270.7" "317.5" "316.8" "306.8" "308.1" "331.9" "392.8" "376.6" "235.8" "" "" "" "" "" "" "" "" "" "" "144.9" "150.1" "181.8" "145.9" "166.0" "171.4" "195.4" "214.4" "211.3" "235.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1978965257736533934" "False" "High" "IsMasterProtein" "Q9NYK5" "Large ribosomal subunit protein mL39 OS=Homo sapiens OX=9606 GN=MRPL39 PE=1 SV=3" "0.000" "False" "3.755" "4" "2" "3" "2" "338" "38.7" "7.65" "6.98" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "" "54148" "ENSG00000154719" "MRPL39" "C9JYA5; hsa:54148; Q32Q74; Q5QTR3; Q96Q65; Q9BSQ7; Q9BZV6; Q9NX44; Q9NYK5" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.037" "0.919" "0.951" "0.906" "1.092" "0.911" "0.769" "0.859" "1.079" "247.8" "257.1" "227.7" "235.8" "224.4" "270.8" "225.7" "190.5" "212.9" "267.3" "" "" "" "" "" "" "" "" "" "" "131.2" "142.5" "130.4" "108.6" "121.4" "150.6" "132.8" "104.0" "119.4" "267.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1726456948051343577" "False" "High" "IsMasterProtein" "Q96G46" "tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like OS=Homo sapiens OX=9606 GN=DUS3L PE=1 SV=2" "0.000" "False" "3.754" "2" "2" "2" "2" "650" "72.5" "8.05" "5.26" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "" "other molecular function" "Pf01207" "56931" "ENSG00000141994" "DUS3L" "hsa:56931; Q96G46; Q96HM5; Q9BSU4; Q9H877; Q9NPR1" "" "" "0" "0" "1.016" "1.026" "1.126" "1.021" "1.002" "1.100" "0.831" "1.064" "3.486" "295.0" "299.7" "302.8" "332.0" "301.2" "295.6" "324.6" "245.0" "314.0" "1028.4" "" "" "" "" "" "" "" "" "" "" "156.2" "166.1" "173.4" "152.9" "162.9" "164.4" "191.0" "133.7" "176.1" "1028.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3054532643706144768" "False" "High" "IsMasterProtein" "Q9H0W9" "Ester hydrolase C11orf54 OS=Homo sapiens OX=9606 GN=C11orf54 PE=1 SV=1" "0.000" "False" "3.752" "5" "2" "2" "2" "315" "35.1" "6.70" "5.11" "2" "" "nucleus" "other molecular function" "Pf08925" "28970" "ENSG00000182919" "C11orf54" "A8K850; hsa:28970; Q6FI88; Q6XYB0; Q96EI3; Q96IX1; Q9H0W9; Q9Y6B4" "" "" "0" "0" "1.024" "1.061" "1.027" "1.143" "1.083" "1.111" "1.006" "0.869" "0.705" "282.6" "289.4" "299.9" "290.2" "323.1" "306.0" "314.0" "284.4" "245.6" "199.1" "" "" "" "" "" "" "" "" "" "" "149.6" "160.5" "171.7" "133.7" "174.8" "170.2" "184.8" "155.2" "137.8" "199.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2874165042467263127" "False" "High" "IsMasterProtein" "Q6PJG6" "BRCA1-associated ATM activator 1 OS=Homo sapiens OX=9606 GN=BRAT1 PE=1 SV=2" "0.000" "False" "3.750" "1" "1" "1" "1" "821" "88.1" "5.27" "3.39" "1" "cell cycle OR cell proliferation;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf02985" "221927" "ENSG00000106009" "BRAT1" "A4D200; C9JY24; hsa:221927; Q6PJG6; Q8IW85; Q8IZ43; Q8WVR8; Q96IV9; Q9H7J8; Q9UFA3" "" "" "0" "0" "1.230" "1.051" "1.016" "1.142" "1.349" "0.856" "0.554" "1.072" "7.014" "65.2" "80.2" "68.5" "66.2" "74.5" "88.0" "55.8" "36.1" "69.9" "457.5" "" "" "" "" "" "" "" "" "" "" "34.5" "44.5" "39.3" "30.5" "40.3" "48.9" "32.9" "19.7" "39.2" "457.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1535429357355427418" "False" "High" "IsMasterProtein" "Q9UL25" "Ras-related protein Rab-21 OS=Homo sapiens OX=9606 GN=RAB21 PE=1 SV=3" "0.000" "False" "3.749" "4" "1" "1" "1" "225" "24.3" "7.94" "2.41" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "23011" "ENSG00000080371" "RAB21" "hsa:23011; Q14466; Q569H3; Q9UL25" "Ciliary landscape" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation" "3" "0" "1.039" "1.036" "1.010" "1.003" "1.007" "1.067" "1.052" "0.963" "0.560" "186.8" "194.1" "193.6" "188.8" "187.4" "188.2" "199.4" "196.5" "179.8" "104.6" "" "" "" "" "" "" "" "" "" "" "98.9" "107.6" "110.9" "86.9" "101.4" "104.7" "117.4" "107.3" "100.9" "104.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1624029487017367107" "False" "High" "IsMasterProtein" "Q9C005" "Protein dpy-30 homolog OS=Homo sapiens OX=9606 GN=DPY30 PE=1 SV=1" "0.000" "False" "3.734" "9" "1" "1" "1" "99" "11.2" "4.88" "3.45" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport" "ER/Golgi;nucleus" "other molecular function" "Pf05186" "84661" "ENSG00000162961" "DPY30" "D6W578; hsa:84661; Q9C005" "Kleefstra syndrome" "Formation of WDR5-containing histone-modifying complexes; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "5" "0" "1.076" "0.953" "0.815" "0.918" "0.851" "1.022" "1.077" "1.028" "0.793" "211.7" "227.7" "201.8" "172.5" "194.4" "180.2" "216.4" "228.1" "217.6" "167.9" "" "" "" "" "" "" "" "" "" "" "112.1" "126.3" "115.6" "79.4" "105.2" "100.2" "127.3" "124.5" "122.1" "167.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8332128719972757989" "False" "High" "IsMasterProtein" "Q8IY67" "Ribonucleoprotein PTB-binding 1 OS=Homo sapiens OX=9606 GN=RAVER1 PE=1 SV=1" "0.000" "False" "3.725" "3" "1" "1" "1" "606" "63.8" "8.48" "3.82" "1" "" "nucleus;other cell component" "" "Pf00076" "125950" "" "RAVER1" "A6NMU4; hsa:125950; Q8IY60; Q8IY67; Q8TF24" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6376451565471680516" "False" "High" "IsMasterProtein" "Q6P4I2" "WD repeat-containing protein 73 OS=Homo sapiens OX=9606 GN=WDR73 PE=1 SV=1" "0.000" "False" "3.723" "3" "1" "3" "1" "378" "41.7" "5.78" "8.77" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "" "" "84942" "ENSG00000177082; ENSG00000291629" "WDR73" "hsa:84942; Q6P4I2; Q96JZ1; Q9P0B7" "Nephrotic syndrome; 15q25 copy number variation" "" "2" "0" "0.998" "0.936" "0.944" "1.178" "1.124" "1.115" "1.021" "1.119" "0.665" "91.3" "91.2" "85.5" "86.2" "107.5" "102.7" "101.8" "93.3" "102.2" "60.7" "" "" "" "" "" "" "" "" "" "" "48.3" "50.5" "48.9" "39.7" "58.2" "57.1" "59.9" "50.9" "57.3" "60.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8365125981762301712" "False" "High" "IsMasterProtein" "P52739" "Zinc finger protein 131 OS=Homo sapiens OX=9606 GN=ZNF131 PE=1 SV=2" "0.000" "False" "3.723" "2" "1" "1" "1" "623" "71.4" "5.19" "2.98" "1" "other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf00651, Pf12874" "7690" "ENSG00000172262" "ZNF131" "B4DRL3; hsa:7690; P52739; Q6PIF0" "" "SUMOylation of transcription cofactors" "1" "0" "0.744" "0.959" "0.879" "1.205" "1.225" "1.833" "1.776" "1.842" "3.297" "25.1" "18.7" "24.1" "22.1" "30.2" "30.7" "46.0" "44.5" "46.2" "82.7" "" "" "" "" "" "" "" "" "" "" "13.3" "10.4" "13.8" "10.2" "16.4" "17.1" "27.1" "24.3" "25.9" "82.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8697887679993430442" "False" "High" "IsMasterProtein" "Q8IYH5" "ZZ-type zinc finger-containing protein 3 OS=Homo sapiens OX=9606 GN=ZZZ3 PE=1 SV=1" "0.000" "False" "3.717" "2" "1" "1" "1" "903" "102.0" "5.69" "2.54" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf00569" "26009" "ENSG00000036549" "ZZZ3" "B7WPC6; hsa:26009; Q6N004; Q6N070; Q8IYH5; Q8IYP0; Q8IYR1; Q8TEK4; Q9Y4U0" "" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7719784497129908869" "False" "High" "IsMasterProtein" "O60566" "Mitotic checkpoint serine/threonine-protein kinase BUB1 beta OS=Homo sapiens OX=9606 GN=BUB1B PE=1 SV=3" "0.000" "False" "3.711" "2" "2" "2" "2" "1050" "119.5" "5.27" "2.35" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf08311" "701" "ENSG00000156970" "BUB1B" "B2R6U0; B4DL09; B4DLG3; hsa:701; O60501; O60566; O60627; O60758; O75389; Q59HH6; Q8WV50; Q96KM4" "Regulation of sister chromatid separation at the metaphase-anaphase transition; 10q22q23 copy number variation" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2083530276327625921" "False" "High" "IsMasterProtein" "Q9BUW7" "Bublin coiled-coil protein OS=Homo sapiens OX=9606 GN=BBLN PE=1 SV=1" "0.000" "False" "3.711" "19" "1" "1" "1" "83" "9.0" "4.22" "2.29" "1" "cell organization and biogenesis" "cytoskeleton;other cell component" "other molecular function" "Pf03670" "79095" "ENSG00000171159" "BBLN" "hsa:79095; Q5SYV8; Q9BUW7; Q9Y3F7" "" "" "0" "0" "1.398" "1.216" "1.328" "1.110" "1.064" "1.180" "1.012" "1.151" "1.178" "24.1" "33.7" "29.3" "32.0" "26.7" "25.6" "28.4" "24.4" "27.7" "28.4" "" "" "" "" "" "" "" "" "" "" "12.8" "18.7" "16.8" "14.7" "14.5" "14.3" "16.7" "13.3" "15.6" "28.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2918128559095144433" "False" "High" "IsMasterProtein" "Q9NRA8" "Eukaryotic translation initiation factor 4E transporter OS=Homo sapiens OX=9606 GN=EIF4ENIF1 PE=1 SV=2" "0.000" "False" "3.708" "1" "1" "1" "1" "985" "108.1" "8.32" "3.56" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10477" "56478" "ENSG00000184708" "EIF4ENIF1" "B1AKL2; B1AKL3; B2RBF1; hsa:56478; Q8NCF2; Q9H708; Q9NRA8" "Primary ovarian insufficiency; 10q11.21q11.23 copy number variation syndrome" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7104112355135180301" "False" "High" "IsMasterProtein" "Q9UL26" "Ras-related protein Rab-22A OS=Homo sapiens OX=9606 GN=RAB22A PE=1 SV=2" "0.000" "False" "3.699" "5" "1" "1" "1" "194" "21.8" "8.15" "3.57" "1" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "57403" "ENSG00000124209" "RAB22A" "B3KR86; E1P605; hsa:57403; Q8TF12; Q9H4E6; Q9UL26" "" "RAB geranylgeranylation" "1" "0" "0.970" "1.097" "1.131" "1.020" "1.114" "0.944" "1.050" "1.070" "0.805" "155.1" "150.5" "170.1" "175.5" "158.2" "172.8" "146.4" "162.8" "165.9" "124.8" "" "" "" "" "" "" "" "" "" "" "82.1" "83.4" "97.4" "80.8" "85.6" "96.1" "86.1" "88.9" "93.1" "124.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8819989402744158112" "False" "High" "IsMasterProtein" "Q96EW2" "HSPB1-associated protein 1 OS=Homo sapiens OX=9606 GN=HSPBAP1 PE=1 SV=1" "0.000" "False" "3.694" "3" "2" "3" "2" "488" "55.1" "5.60" "5.97" "2" "" "other cell component" "other molecular function" "Pf13621" "79663" "ENSG00000169087" "HSPBAP1" "hsa:79663; Q6P476; Q8N8J4; Q8NHH6; Q8WWF0; Q96EW2" "" "" "0" "0" "1.101" "1.015" "0.970" "0.962" "0.986" "1.097" "0.914" "1.096" "1.048" "81.1" "89.3" "82.3" "78.6" "78.0" "79.9" "89.0" "74.1" "88.9" "84.9" "" "" "" "" "" "" "" "" "" "" "42.9" "49.5" "47.1" "36.2" "42.2" "44.5" "52.4" "40.4" "49.8" "84.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8110732802669380645" "False" "High" "IsMasterProtein" "P24864" "G1/S-specific cyclin-E1 OS=Homo sapiens OX=9606 GN=CCNE1 PE=1 SV=2" "0.000" "False" "3.689" "4" "2" "2" "2" "410" "47.0" "6.04" "3.89" "2" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00134, Pf02984" "898" "ENSG00000105173" "CCNE1" "A8K684; hsa:898; P24864; Q14091; Q8NFG1; Q92501; Q9UD21" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway; Retinoblastoma gene in cancer; ATM signaling pathway; Vitamin D receptor pathway; Photodynamic therapy-induced AP-1 survival signaling; PI3K-Akt signaling pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; p53 transcriptional gene network; Pleural mesothelioma; GDNF signaling; Urotensin-II-mediated signaling pathway; ID signaling pathway; TROP2 regulatory signaling; NF1 copy number variation syndrome ; DNA damage response" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; Association of TriC/CCT with target proteins during biosynthesis; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); RHOBTB3 ATPase cycle; DNA Damage/Telomere Stress Induced Senescence; G1/S-Specific Transcription; G0 and Early G1; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; p53-Dependent G1 DNA Damage Response; PTK6 Regulates Cell Cycle" "38" "0" "1.077" "1.163" "1.312" "1.316" "1.233" "1.532" "1.517" "1.366" "0.887" "165.8" "178.6" "192.8" "217.5" "218.2" "204.3" "254.0" "251.4" "226.5" "147.1" "" "" "" "" "" "" "" "" "" "" "87.8" "99.0" "110.4" "100.1" "118.0" "113.7" "149.5" "137.2" "127.0" "147.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3666835465541347575" "False" "High" "IsMasterProtein" "Q14684" "Ribosomal RNA processing protein 1 homolog B OS=Homo sapiens OX=9606 GN=RRP1B PE=1 SV=3" "0.000" "False" "3.687" "1" "1" "1" "1" "758" "84.4" "9.76" "2.92" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05997" "23076" "ENSG00000160208" "RRP1B" "hsa:23076; Q14684; Q8TBZ4" "" "" "0" "0" "1.419" "1.045" "1.341" "1.409" "1.103" "1.233" "1.072" "1.271" "0.945" "82.7" "117.3" "86.4" "110.9" "116.5" "91.2" "102.0" "88.6" "105.1" "78.1" "" "" "" "" "" "" "" "" "" "" "43.8" "65.0" "49.5" "51.1" "63.0" "50.7" "60.0" "48.4" "59.0" "78.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5788074156748143009" "False" "High" "IsMasterProtein" "Q96IJ6" "Mannose-1-phosphate guanyltransferase alpha OS=Homo sapiens OX=9606 GN=GMPPA PE=1 SV=1" "0.000" "False" "3.682" "2" "1" "1" "1" "420" "46.3" "7.21" "3.65" "1" "other metabolic processes" "other cell component" "other molecular function" "Pf00132, Pf00483" "29926" "ENSG00000144591" "GMPPA" "A6NJ74; A8K3Q6; B3KMT4; hsa:29926; Q53GI0; Q96IJ6; Q9NWC3; Q9Y5P5" "N-glycan biosynthesis" "Synthesis of GDP-mannose" "2" "0" "1.011" "0.993" "1.047" "1.048" "1.089" "1.040" "1.077" "1.109" "0.695" "254.1" "256.8" "252.4" "266.0" "266.2" "276.8" "264.3" "273.6" "281.8" "176.5" "" "" "" "" "" "" "" "" "" "" "134.5" "142.4" "144.6" "122.5" "144.0" "153.9" "155.5" "149.4" "158.1" "176.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3695777178307527150" "False" "High" "IsMasterProtein" "Q9BZL1" "Ubiquitin-like protein 5 OS=Homo sapiens OX=9606 GN=UBL5 PE=1 SV=1" "0.000" "False" "3.680" "12" "1" "2" "1" "73" "8.5" "8.44" "6.34" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00240" "59286" "ENSG00000198258" "UBL5" "hsa:59286; Q2NL89; Q9BZL1" "" "mRNA Splicing - Major Pathway" "1" "0" "1.059" "1.027" "1.097" "0.988" "1.011" "1.045" "0.925" "0.978" "1.700" "528.6" "559.5" "543.1" "579.7" "522.4" "534.4" "552.1" "488.8" "516.7" "898.6" "" "" "" "" "" "" "" "" "" "" "279.9" "310.2" "311.0" "267.0" "282.6" "297.2" "324.9" "266.8" "289.9" "898.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7576893625228470779" "False" "High" "IsMasterProtein" "Q9H410" "Kinetochore-associated protein DSN1 homolog OS=Homo sapiens OX=9606 GN=DSN1 PE=1 SV=2" "0.000" "False" "3.676" "4" "1" "2" "1" "356" "40.0" "7.05" "2.24" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf08202" "79980" "ENSG00000149636" "DSN1" "B4DWT2; E1P5U9; hsa:79980; Q5JW55; Q5JW56; Q9H410; Q9H8P4" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Neutrophil degranulation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5772748486031489240" "False" "High" "IsMasterProtein" "Q9Y3R5" "Protein dopey-2 OS=Homo sapiens OX=9606 GN=DOP1B PE=1 SV=5" "0.000" "False" "3.673" "0" "1" "1" "1" "2298" "258.1" "6.29" "3.02" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "" "Pf04118" "9980" "ENSG00000142197" "DOP1B" "D3DSG5; hsa:9980; Q6PJQ7; Q9UEZ3; Q9Y3R5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3637812855525000132" "False" "High" "IsMasterProtein" "Q2KHR2" "DNA-binding protein RFX7 OS=Homo sapiens OX=9606 GN=RFX7 PE=1 SV=2" "0.000" "False" "3.669" "1" "1" "1" "1" "1460" "157.3" "6.61" "1.94" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02257" "64864" "ENSG00000181827" "RFX7" "hsa:64864; Q2KHR2; Q6ZRR1; Q6ZTY6; Q8N3J0; Q9H7A9; Q9H956" "" "" "0" "0" "1.182" "1.275" "1.174" "1.198" "1.677" "1.121" "1.436" "1.564" "1.568" "35.1" "41.5" "44.8" "41.2" "42.1" "58.9" "39.4" "50.4" "54.9" "55.1" "" "" "" "" "" "" "" "" "" "" "18.6" "23.0" "25.6" "19.0" "22.8" "32.8" "23.2" "27.5" "30.8" "55.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2555536461123867922" "False" "High" "IsMasterProtein" "Q86U90" "Threonylcarbamoyl-AMP synthase OS=Homo sapiens OX=9606 GN=YRDC PE=1 SV=1" "0.000" "False" "3.667" "4" "1" "1" "1" "279" "29.3" "8.57" "2.89" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf01300" "79693" "ENSG00000196449" "YRDC" "hsa:79693; Q4W4X8; Q6NVW3; Q7L4E4; Q7Z2I4; Q86U90; Q9H5F8" "" "" "0" "0" "1.488" "1.212" "1.533" "1.779" "1.396" "1.557" "0.983" "0.980" "0.979" "28.1" "41.8" "34.0" "43.1" "50.0" "39.2" "43.7" "27.6" "27.5" "27.5" "" "" "" "" "" "" "" "" "" "" "14.9" "23.2" "19.5" "19.8" "27.0" "21.8" "25.7" "15.1" "15.4" "27.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2350737749617918576" "False" "High" "IsMasterProtein" "Q5TAQ9" "DDB1- and CUL4-associated factor 8 OS=Homo sapiens OX=9606 GN=DCAF8 PE=1 SV=1" "0.000" "False" "3.655" "2" "2" "2" "2" "597" "66.8" "5.39" "2.34" "2" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "" "Pf00400" "50717" "ENSG00000132716" "DCAF8" "D3DVE6; hsa:50717; Q12839; Q4QQI6; Q53F14; Q5TAQ9; Q66K50; Q68CS7; Q96E00" "" "Neddylation" "1" "0" "1.023" "1.044" "1.105" "1.004" "1.094" "0.929" "1.030" "1.086" "1.390" "145.1" "148.5" "151.5" "160.3" "145.7" "158.8" "134.8" "149.5" "157.6" "201.7" "" "" "" "" "" "" "" "" "" "" "76.8" "82.3" "86.7" "73.8" "78.8" "88.3" "79.4" "81.6" "88.4" "201.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "385044699666679526" "False" "High" "IsMasterProtein" "P49756" "RNA-binding protein 25 OS=Homo sapiens OX=9606 GN=RBM25 PE=1 SV=3" "0.000" "False" "3.655" "2" "2" "2" "2" "843" "100.1" "6.32" "4.32" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf01480" "58517" "ENSG00000119707" "RBM25" "A0PJL9; B2RNA8; B3KT03; hsa:58517; P49756; Q2TA72; Q5XJ17; Q6P665; Q9H6A1; Q9UEQ5; Q9UIE9" "" "mRNA Splicing - Major Pathway" "1" "0" "1.036" "1.027" "1.024" "1.095" "1.061" "1.052" "1.146" "1.337" "1.968" "194.9" "201.8" "200.1" "199.5" "213.3" "206.8" "205.0" "223.3" "260.5" "383.5" "" "" "" "" "" "" "" "" "" "" "103.2" "111.9" "114.6" "91.9" "115.4" "115.0" "120.6" "121.9" "146.1" "383.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8371930933438372012" "False" "High" "IsMasterProtein" "P30039" "Phenazine biosynthesis-like domain-containing protein OS=Homo sapiens OX=9606 GN=PBLD PE=1 SV=2" "0.000" "False" "3.650" "5" "1" "1" "1" "288" "31.8" "6.52" "2.11" "1" "other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf02567" "64081" "ENSG00000108187" "PBLD" "A8MZJ3; C9JIM0; hsa:64081; P30039; Q9HCC2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8787657634019778386" "False" "High" "IsMasterProtein" "Q2TAA2" "Isoamyl acetate-hydrolyzing esterase 1 homolog OS=Homo sapiens OX=9606 GN=IAH1 PE=1 SV=1" "0.000" "False" "3.650" "3" "1" "1" "1" "248" "27.6" "5.30" "3.46" "1" "other metabolic processes" "" "other molecular function" "Pf00657" "285148" "ENSG00000134330" "IAH1" "B4DMV3; hsa:285148; Q2TAA2" "" "" "0" "0" "1.190" "1.137" "1.157" "1.116" "1.116" "1.130" "1.139" "0.964" "0.565" "184.2" "219.3" "209.5" "213.2" "205.6" "205.5" "208.1" "209.9" "177.7" "104.1" "" "" "" "" "" "" "" "" "" "" "97.5" "121.6" "120.0" "98.2" "111.3" "114.3" "122.5" "114.6" "99.7" "104.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-826752614338264709" "False" "High" "IsMasterProtein" "P54792" "Putative segment polarity protein dishevelled homolog DVL1P1 OS=Homo sapiens OX=9606 GN=DVL1P1 PE=5 SV=1" "0.000" "False" "3.641" "3" "2" "2" "1" "670" "73.2" "6.46" "2.14" "2" "cell-cell signaling;developmental processes;signal transduction" "cytosol" "signal transduction activity or receptor binding" "Pf00595, Pf00610, Pf00778, Pf02377, Pf12316" "" "" "DVL1P1" "P54792" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6643122719444543200" "False" "High" "IsMasterProtein" "Q96CB8" "Integrator complex subunit 12 OS=Homo sapiens OX=9606 GN=INTS12 PE=1 SV=1" "0.000" "False" "3.631" "2" "1" "1" "1" "462" "48.8" "9.69" "2.46" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00628" "57117" "ENSG00000138785" "INTS12" "B2RC48; hsa:57117; Q3B6Z3; Q96CB8; Q9HD71" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1964659957025433859" "False" "High" "IsMasterProtein" "Q9H2H8" "Peptidyl-prolyl cis-trans isomerase-like 3 OS=Homo sapiens OX=9606 GN=PPIL3 PE=1 SV=1" "0.000" "False" "3.631" "11" "2" "2" "2" "161" "18.1" "6.79" "4.61" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00160" "53938" "ENSG00000240344" "PPIL3" "hsa:53938; Q86WF9; Q96IA9; Q9BXZ1; Q9H2H8" "" "mRNA Splicing - Major Pathway" "1" "0" "1.146" "1.029" "1.229" "1.035" "1.055" "1.365" "0.980" "0.857" "1.486" "262.7" "301.1" "270.2" "322.9" "272.0" "277.1" "358.6" "257.6" "225.1" "390.5" "" "" "" "" "" "" "" "" "" "" "139.1" "166.9" "154.7" "148.7" "147.1" "154.1" "211.0" "140.6" "126.3" "390.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7019899548710588854" "False" "High" "IsMasterProtein" "Q14409" "Glycerol kinase 3 OS=Homo sapiens OX=9606 GN=GK3 PE=1 SV=2" "0.000" "False" "3.615" "1" "1" "1" "1" "553" "60.6" "6.39" "3.14" "1" "other metabolic processes" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf00370, Pf02782" "" "ENSG00000229894" "GK3" "Q14409; Q6NXP9" "PPAR signaling pathway" "Triglyceride biosynthesis" "2" "0" "1.148" "1.057" "1.068" "1.112" "1.157" "1.067" "0.977" "0.998" "0.715" "197.9" "227.3" "209.1" "211.3" "220.1" "228.9" "211.2" "193.2" "197.5" "141.4" "" "" "" "" "" "" "" "" "" "" "104.8" "126.0" "119.7" "97.3" "119.1" "127.3" "124.3" "105.5" "110.8" "141.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4967906594537230573" "False" "High" "IsMasterProtein" "Q9NUG6" "p53 and DNA damage-regulated protein 1 OS=Homo sapiens OX=9606 GN=PDRG1 PE=1 SV=2" "0.000" "False" "3.614" "6" "1" "1" "1" "133" "15.5" "6.06" "3.17" "1" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf01920" "81572" "ENSG00000088356" "PDRG1" "B2R511; hsa:81572; Q96GP3; Q9BUW8; Q9NUG6" "" "" "0" "0" "1.058" "1.068" "1.143" "1.038" "0.997" "1.279" "1.471" "1.295" "0.951" "171.6" "181.5" "183.3" "196.1" "178.1" "171.0" "219.4" "252.4" "222.1" "163.2" "" "" "" "" "" "" "" "" "" "" "90.9" "100.6" "105.0" "90.3" "96.3" "95.1" "129.1" "137.8" "124.6" "163.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6830968360322984650" "False" "High" "IsMasterProtein" "Q9BTV6" "Diphthine methyltransferase OS=Homo sapiens OX=9606 GN=DPH7 PE=1 SV=2" "0.000" "False" "3.611" "4" "2" "2" "2" "452" "50.5" "6.60" "5.00" "2" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00400" "92715" "ENSG00000148399" "DPH7" "hsa:92715; Q96AB7; Q9BTV6" "" "Synthesis of diphthamide-EEF2" "1" "0" "1.023" "1.027" "1.122" "1.075" "1.030" "1.035" "1.041" "1.021" "0.737" "405.4" "414.9" "416.4" "454.7" "435.7" "417.4" "419.7" "422.2" "413.8" "298.8" "" "" "" "" "" "" "" "" "" "" "214.6" "230.0" "238.5" "209.4" "235.7" "232.2" "247.0" "230.5" "232.1" "298.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1529174177095472519" "False" "High" "IsMasterProtein" "O14777" "Kinetochore protein NDC80 homolog OS=Homo sapiens OX=9606 GN=NDC80 PE=1 SV=1" "0.000" "False" "3.604" "3" "2" "2" "2" "642" "73.9" "5.60" "5.36" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03801, Pf18077" "10403" "ENSG00000080986" "NDC80" "hsa:10403; O14777; Q6PJX2" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "0.999" "0.994" "1.169" "1.128" "1.062" "1.006" "0.449" "1.008" "7.055" "137.3" "137.1" "136.4" "160.5" "154.9" "145.8" "138.1" "61.7" "138.4" "968.4" "" "" "" "" "" "" "" "" "" "" "72.7" "76.0" "78.1" "73.9" "83.8" "81.1" "81.3" "33.7" "77.6" "968.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6543857744544751788" "False" "High" "IsMasterProtein" "P38571" "Lysosomal acid lipase/cholesteryl ester hydrolase OS=Homo sapiens OX=9606 GN=LIPA PE=1 SV=2" "0.000" "False" "3.602" "4" "2" "3" "2" "399" "45.4" "6.92" "6.36" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00561" "3988" "ENSG00000107798" "LIPA" "B2RBH5; D3DR29; hsa:3988; P38571; Q16529; Q53H21; Q5T074; Q5T771; Q96EJ0" "Phase I biotransformations, non-P450; Degradation pathway of sphingolipids, including diseases; Cholesterol metabolism" "LDL clearance" "4" "0" "0.959" "1.067" "0.967" "1.074" "1.272" "1.161" "1.001" "0.956" "0.587" "165.1" "158.3" "176.2" "159.7" "177.4" "210.1" "191.6" "165.3" "157.9" "96.9" "" "" "" "" "" "" "" "" "" "" "87.4" "87.8" "100.9" "73.5" "96.0" "116.9" "112.8" "90.2" "88.6" "96.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6256207077144686062" "False" "High" "IsMasterProtein" "Q9UK61" "Protein TASOR OS=Homo sapiens OX=9606 GN=TASOR PE=1 SV=3" "0.000" "False" "3.600" "1" "1" "1" "1" "1670" "188.9" "5.80" "2.74" "1" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12509" "23272" "ENSG00000163946" "TASOR" "A1L3A4; B5ME28; hsa:23272; Q9H2F7; Q9UK61; Q9UPP7" "" "" "0" "0" "0.971" "1.137" "1.278" "0.867" "1.023" "1.902" "1.609" "1.526" "0.965" "69.8" "67.8" "79.4" "89.3" "60.5" "71.4" "132.8" "112.4" "106.6" "67.4" "" "" "" "" "" "" "" "" "" "" "37.0" "37.6" "45.5" "41.1" "32.8" "39.7" "78.2" "61.3" "59.8" "67.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5130532040742567239" "False" "High" "IsMasterProtein" "Q9HCN8" "Stromal cell-derived factor 2-like protein 1 OS=Homo sapiens OX=9606 GN=SDF2L1 PE=1 SV=2" "0.000" "False" "3.599" "7" "2" "5" "2" "221" "23.6" "7.03" "11.16" "2" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf02815" "23753" "ENSG00000128228" "SDF2L1" "A2RUD3; hsa:23753; Q9BRI5; Q9HCN8" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.975" "0.987" "1.032" "1.181" "1.077" "1.040" "1.024" "0.952" "0.985" "139.2" "135.7" "137.5" "143.6" "164.4" "149.9" "144.8" "142.6" "132.5" "137.2" "" "" "" "" "" "" "" "" "" "" "73.7" "75.3" "78.7" "66.2" "89.0" "83.4" "85.2" "77.8" "74.3" "137.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4388316332710741736" "False" "High" "IsMasterProtein" "Q96FS4" "Signal-induced proliferation-associated protein 1 OS=Homo sapiens OX=9606 GN=SIPA1 PE=1 SV=1" "0.000" "False" "3.597" "1" "1" "1" "1" "1042" "112.1" "6.60" "3.28" "1" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity" "Pf00595, Pf02145, Pf21022" "6494" "ENSG00000213445" "SIPA1" "hsa:6494; O14518; O60484; O60618; Q2YD83; Q96FS4" "MAPK cascade" "Rap1 signalling" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3115321329155830276" "False" "High" "IsMasterProtein" "Q9P2D0" "Inhibitor of Bruton tyrosine kinase OS=Homo sapiens OX=9606 GN=IBTK PE=1 SV=3" "0.000" "False" "3.596" "1" "2" "2" "2" "1353" "150.4" "7.71" "4.25" "2" "transport;other biological processes" "other membranes;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00415, Pf00651, Pf12796" "25998" "ENSG00000005700; ENSG00000283068" "IBTK" "hsa:25998; Q2QKU2; Q2QKU3; Q2QKU4; Q5TFD7; Q5TFD9; Q8IUQ9; Q8IUY7; Q8TAI4; Q9HBI8; Q9P2D0; Q9Y3T8" "Genetic causes of porto-sinusoidal vascular disease" "" "1" "0" "0.989" "0.979" "1.092" "1.160" "1.069" "0.990" "1.005" "1.078" "1.101" "157.5" "155.7" "154.1" "172.0" "182.7" "168.4" "155.9" "158.2" "169.7" "173.3" "" "" "" "" "" "" "" "" "" "" "83.4" "86.3" "88.2" "79.2" "98.9" "93.7" "91.7" "86.4" "95.2" "173.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-599104977835536313" "False" "High" "IsMasterProtein" "P28799" "Progranulin OS=Homo sapiens OX=9606 GN=GRN PE=1 SV=2" "0.000" "False" "3.588" "2" "1" "1" "1" "593" "63.5" "6.83" "2.65" "1" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "signal transduction activity or receptor binding;other molecular function" "Pf00396" "2896" "ENSG00000030582" "GRN" "D3DX55; hsa:2896; P23781; P23782; P23783; P23784; P28799; Q53HQ8; Q53Y88; Q540U8; Q9BWE7; Q9H8S1; Q9UCH0" "IL-18 signaling pathway" "Neutrophil degranulation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6910924152517685584" "False" "High" "IsMasterProtein" "P13612" "Integrin alpha-4 OS=Homo sapiens OX=9606 GN=ITGA4 PE=1 SV=3" "0.000" "False" "3.586" "2" "2" "2" "2" "1032" "114.8" "6.48" "4.29" "2" "cell adhesion;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01839, Pf08441, Pf20805, Pf20806" "3676" "ENSG00000115232" "ITGA4" "D3DPG4; hsa:3676; P13612; Q7Z4L6" "Integrin-mediated cell adhesion; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ebola virus infection in host; Cells and molecules involved in local acute inflammatory response ; Pleural mesothelioma; 11p11.2 copy number variation syndrome" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Potential therapeutics for SARS; Integrin cell surface interactions; RUNX3 Regulates Immune Response and Cell Migration" "14" "0" "0.995" "1.091" "1.363" "1.076" "1.305" "1.089" "0.936" "1.167" "0.849" "91.1" "90.7" "99.4" "124.2" "98.0" "118.9" "99.3" "85.3" "106.3" "77.3" "" "" "" "" "" "" "" "" "" "" "48.2" "50.3" "56.9" "57.2" "53.0" "66.1" "58.4" "46.6" "59.6" "77.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4429006779143257910" "False" "High" "IsMasterProtein" "Q14320" "Protein FAM50A OS=Homo sapiens OX=9606 GN=FAM50A PE=1 SV=2" "0.000" "False" "3.582" "4" "2" "2" "2" "339" "40.2" "6.83" "2.57" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf04921" "9130" "ENSG00000071859" "FAM50A" "A8KAQ4; B2R997; hsa:9130; Q14320; Q5HY37; Q6PJH5" "" "mRNA Splicing - Major Pathway" "1" "0" "1.166" "1.352" "1.015" "0.823" "0.909" "0.816" "1.115" "0.931" "0.906" "60.2" "70.2" "81.4" "61.1" "49.5" "54.7" "49.1" "67.1" "56.0" "54.5" "" "" "" "" "" "" "" "" "" "" "31.9" "38.9" "46.6" "28.1" "26.8" "30.4" "28.9" "36.6" "31.4" "54.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7640891103846222335" "False" "High" "IsMasterProtein" "O94819" "Kelch repeat and BTB domain-containing protein 11 OS=Homo sapiens OX=9606 GN=KBTBD11 PE=1 SV=1" "0.000" "False" "3.582" "2" "1" "1" "1" "623" "65.7" "6.07" "2.95" "1" "" "" "" "Pf00651, Pf01344" "9920" "ENSG00000176595; ENSG00000273645" "KBTBD11" "hsa:9920; O94819; Q3L1I0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3331965257696457103" "False" "High" "IsMasterProtein" "Q9H467" "CUE domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CUEDC2 PE=1 SV=1" "0.000" "False" "3.570" "3" "1" "2" "1" "287" "32.0" "4.81" "5.14" "1" "other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf02845" "79004" "ENSG00000107874" "CUEDC2" "D3DR88; hsa:79004; Q9BWG8; Q9H467" "" "" "0" "0" "1.101" "1.085" "1.105" "1.093" "1.079" "1.066" "1.170" "1.432" "1.200" "145.3" "159.9" "157.7" "160.5" "158.9" "156.7" "154.9" "170.0" "208.1" "174.3" "" "" "" "" "" "" "" "" "" "" "76.9" "88.7" "90.3" "73.9" "86.0" "87.2" "91.2" "92.8" "116.7" "174.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4105877346039324927" "False" "High" "IsMasterProtein" "Q9BV29" "Coiled-coil domain-containing protein 32 OS=Homo sapiens OX=9606 GN=CCDC32 PE=1 SV=2" "0.000" "False" "3.565" "5" "1" "1" "1" "185" "20.6" "4.53" "3.47" "1" "cell organization and biogenesis;other biological processes" "other membranes" "" "Pf14989" "90416" "ENSG00000128891" "CCDC32" "A8KAL4; Q86TC4; Q8N788; Q8NAR7; Q9BV29" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8892747589052197154" "False" "High" "IsMasterProtein" "Q5W0B1" "ORC ubiquitin ligase 1 OS=Homo sapiens OX=9606 GN=OBI1 PE=1 SV=1" "0.000" "False" "3.562" "1" "1" "1" "1" "726" "81.1" "5.72" "2.91" "1" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf13923" "79596" "ENSG00000152193" "OBI1" "B2RN99; hsa:79596; Q5W0B1; Q8TBY2; Q9H0T2; Q9H8M0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-538659723289809135" "False" "High" "IsMasterProtein" "Q13950" "Runt-related transcription factor 2 OS=Homo sapiens OX=9606 GN=RUNX2 PE=1 SV=2" "0.000" "False" "3.562" "2" "1" "2" "1" "521" "56.6" "8.85" "4.95" "1" "cell cycle OR cell proliferation;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00853, Pf08504" "860" "ENSG00000124813" "RUNX2" "hsa:860; O14614; O14615; O95181; Q13950" "Androgen receptor signaling pathway; Bone morphogenic protein signaling and regulation; Cell differentiation - expanded index; Interleukin-11 signaling pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Development of pulmonary dendritic cells and macrophage subsets; OSX and miRNAs in tooth development; Endochondral ossification; IL-18 signaling pathway; Osteoblast differentiation and related diseases; Endochondral ossification with skeletal dysplasias; TGF-beta receptor signaling in skeletal dysplasias; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Orexin receptor pathway; Clock-controlled autophagy in bone metabolism; Osteoarthritic chondrocyte hypertrophy; TGF-beta receptor signaling" "" "20" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8514110242710764604" "False" "High" "IsMasterProtein" "P48553" "Trafficking protein particle complex subunit 10 OS=Homo sapiens OX=9606 GN=TRAPPC10 PE=1 SV=2" "0.000" "False" "3.561" "1" "1" "1" "1" "1259" "142.1" "6.04" "3.15" "1" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf12584" "7109" "ENSG00000160218" "TRAPPC10" "hsa:7109; P48553; Q3MIR2; Q86SI7; Q9UMD4; Q9Y4L3" "" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "2" "0" "0.812" "0.726" "1.004" "0.921" "0.846" "0.845" "0.793" "0.827" "1.028" "115.7" "93.9" "84.0" "116.1" "106.5" "97.8" "97.7" "91.8" "95.7" "119.0" "" "" "" "" "" "" "" "" "" "" "61.3" "52.1" "48.1" "53.5" "57.6" "54.4" "57.5" "50.1" "53.7" "119.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8531789863272175239" "False" "High" "IsMasterProtein" "Q9BU89" "Deoxyhypusine hydroxylase OS=Homo sapiens OX=9606 GN=DOHH PE=1 SV=1" "0.000" "False" "3.556" "4" "1" "1" "1" "302" "32.9" "4.83" "2.55" "1" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf13646" "83475" "ENSG00000129932" "DOHH" "O75265; Q9BU89" "" "Hypusine synthesis from eIF5A-lysine" "1" "0" "1.134" "1.189" "1.288" "1.102" "0.982" "1.098" "0.914" "0.970" "2.534" "62.0" "70.3" "73.7" "79.9" "68.3" "60.9" "68.1" "56.7" "60.1" "157.1" "" "" "" "" "" "" "" "" "" "" "32.8" "39.0" "42.2" "36.8" "37.0" "33.9" "40.1" "30.9" "33.7" "157.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6537732196203622572" "False" "High" "IsMasterProtein" "Q8N884" "Cyclic GMP-AMP synthase OS=Homo sapiens OX=9606 GN=CGAS PE=1 SV=2" "0.000" "False" "3.555" "2" "1" "1" "1" "522" "58.8" "9.48" "1.97" "1" "cell-cell signaling;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03281, Pf20266" "115004" "ENSG00000164430" "CGAS" "hsa:115004; L0L2J9; Q14CV6; Q32NC9; Q5SWL0; Q5SWL1; Q8N884; Q96E45" "Cytosolic DNA-sensing pathway; STING pathway in Kawasaki-like disease and COVID-19; Lung pathology of COVID-19; 8p23.1 copy number variation syndrome" "STING mediated induction of host immune responses" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6271910638518906992" "False" "High" "IsMasterProtein" "Q92552" "Small ribosomal subunit protein mS27 OS=Homo sapiens OX=9606 GN=MRPS27 PE=1 SV=3" "0.000" "False" "3.552" "2" "1" "2" "1" "414" "47.6" "6.18" "6.04" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf10037" "23107" "ENSG00000113048" "MRPS27" "B4DRT2; hsa:23107; Q6P1S1; Q92552" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.041" "0.923" "0.998" "1.021" "0.937" "0.996" "0.820" "0.923" "1.979" "323.5" "336.7" "298.5" "322.9" "330.2" "303.0" "322.3" "265.2" "298.5" "640.3" "" "" "" "" "" "" "" "" "" "" "171.3" "186.7" "171.0" "148.7" "178.6" "168.5" "189.7" "144.8" "167.5" "640.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6639760008816947129" "False" "High" "IsMasterProtein" "Q6ZUM4" "Rho GTPase-activating protein 27 OS=Homo sapiens OX=9606 GN=ARHGAP27 PE=1 SV=3" "0.000" "False" "3.551" "1" "1" "1" "1" "889" "98.3" "5.59" "3.12" "1" "transport;signal transduction;other biological processes" "other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00397, Pf00620" "201176" "ENSG00000159314; ENSG00000276836; ENSG00000276907" "ARHGAP27" "A4FU35; A8K3N5; C9JTF3; hsa:201176; Q494U0; Q6NWZ8; Q6ZUM4; Q8WY58" "" "CDC42 GTPase cycle; RAC1 GTPase cycle" "2" "0" "1.060" "0.936" "1.081" "1.070" "1.050" "1.106" "1.049" "1.312" "1.169" "127.0" "134.6" "118.9" "137.3" "135.9" "133.4" "140.5" "133.3" "166.6" "148.4" "" "" "" "" "" "" "" "" "" "" "67.3" "74.6" "68.1" "63.2" "73.5" "74.2" "82.7" "72.8" "93.5" "148.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2749057131699299074" "False" "High" "IsMasterProtein" "Q9BSY4" "Coiled-coil-helix-coiled-coil-helix domain-containing protein 5 OS=Homo sapiens OX=9606 GN=CHCHD5 PE=1 SV=1" "0.000" "False" "3.549" "12" "1" "1" "1" "110" "12.4" "6.73" "2.85" "1" "other metabolic processes" "mitochondrion" "" "Pf06747, Pf16860" "84269" "ENSG00000125611" "CHCHD5" "hsa:84269; Q585T4; Q8N8C4; Q9BSY4" "2q13 copy number variation syndrome" "Mitochondrial protein import" "2" "0" "0.770" "0.764" "0.984" "0.951" "0.903" "0.803" "0.940" "0.796" "0.751" "53.2" "41.0" "40.7" "52.4" "50.6" "48.1" "42.8" "50.0" "42.4" "40.0" "" "" "" "" "" "" "" "" "" "" "28.2" "22.7" "23.3" "24.1" "27.4" "26.7" "25.2" "27.3" "23.8" "40.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-720179637671099041" "False" "High" "IsMasterProtein" "Q06546" "GA-binding protein alpha chain OS=Homo sapiens OX=9606 GN=GABPA PE=1 SV=1" "0.000" "False" "3.549" "2" "1" "1" "1" "454" "51.3" "4.97" "3.29" "1" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf02198, Pf11620" "2551" "ENSG00000154727" "GABPA" "hsa:2551; Q06546; Q12939" "Energy metabolism; Allograft rejection; Myometrial relaxation and contraction pathways; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Mitochondrial gene expression; Pleural mesothelioma" "Transcriptional activation of mitochondrial biogenesis" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8914003618785624230" "False" "High" "IsMasterProtein" "O75934" "Pre-mRNA-splicing factor SPF27 OS=Homo sapiens OX=9606 GN=BCAS2 PE=1 SV=1" "0.000" "False" "3.538" "5" "1" "1" "1" "225" "26.1" "5.66" "2.32" "1" "RNA metabolism OR transcription;other metabolic processes" "cytoskeleton;nucleus;other cell component" "" "Pf05700" "10286" "ENSG00000116752" "BCAS2" "hsa:10286; O75934; Q6FGS0" "" "mRNA Splicing - Major Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6591516084365101626" "False" "High" "IsMasterProtein" "Q9H5X1" "Cytosolic iron-sulfur assembly component 2A OS=Homo sapiens OX=9606 GN=CIAO2A PE=1 SV=1" "0.000" "False" "3.537" "7" "1" "3" "1" "160" "18.3" "4.88" "4.51" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01883" "84191" "ENSG00000166797" "CIAO2A" "A6NKS1; B2R5F8; B7Z8Z5; hsa:84191; Q9H5X1" "2q11.2 copy number variation syndrome" "" "1" "0" "1.050" "1.001" "1.071" "1.034" "0.946" "1.000" "1.078" "0.953" "0.644" "397.5" "417.5" "397.9" "425.7" "411.1" "376.1" "397.4" "428.4" "379.0" "256.2" "" "" "" "" "" "" "" "" "" "" "210.5" "231.5" "227.9" "196.0" "222.4" "209.2" "233.9" "233.9" "212.6" "256.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-404480449398085068" "False" "High" "IsMasterProtein" "P51809" "Vesicle-associated membrane protein 7 OS=Homo sapiens OX=9606 GN=VAMP7 PE=1 SV=3" "0.000" "False" "3.536" "7" "2" "2" "2" "220" "24.9" "8.60" "5.43" "2" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00957, Pf13774" "6845" "ENSG00000124333; ENSG00000292366" "VAMP7" "hsa:6845; P51809; Q53GY7; Q7Z409; Q9H4A7" "" "Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; Interleukin-12 signaling" "6" "0" "1.082" "0.933" "1.139" "1.084" "1.087" "1.558" "1.592" "1.451" "0.844" "421.5" "456.0" "393.2" "480.2" "456.9" "458.2" "656.6" "670.8" "611.7" "355.8" "" "" "" "" "" "" "" "" "" "" "223.2" "252.8" "225.2" "221.2" "247.2" "254.9" "386.4" "366.2" "343.1" "355.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7167041566668473319" "False" "High" "IsMasterProtein" "Q96RK0" "Protein capicua homolog OS=Homo sapiens OX=9606 GN=CIC PE=1 SV=3" "0.000" "False" "3.535" "0" "1" "2" "1" "2517" "257.9" "8.10" "4.75" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf16090" "23152" "ENSG00000079432" "CIC" "A0A7P0T9K5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7332918538450832394" "False" "High" "IsMasterProtein" "P18847" "Cyclic AMP-dependent transcription factor ATF-3 OS=Homo sapiens OX=9606 GN=ATF3 PE=1 SV=2" "0.000" "False" "3.534" "6" "1" "1" "1" "181" "20.6" "8.54" "3.27" "1" "other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "467" "ENSG00000162772" "ATF3" "hsa:467; P18847; Q5VTZ2; Q6ICQ9; Q7Z566; Q8WYM6" "Myometrial relaxation and contraction pathways; Photodynamic therapy-induced unfolded protein response; TGF-beta signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; IL-18 signaling pathway; Pleural mesothelioma; CCL18 signaling pathway; Hypertrophy model" "Response of EIF2AK1 (HRI) to heme deficiency; ATF4 activates genes in response to endoplasmic reticulum stress; Response of EIF2AK4 (GCN2) to amino acid deficiency" "11" "0" "1.143" "1.085" "1.436" "1.202" "1.182" "1.184" "1.243" "1.160" "1.380" "80.5" "92.0" "87.3" "115.6" "96.8" "95.1" "95.3" "100.0" "93.3" "111.0" "" "" "" "" "" "" "" "" "" "" "42.6" "51.0" "50.0" "53.2" "52.3" "52.9" "56.1" "54.6" "52.3" "111.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6471377721056749589" "False" "High" "IsMasterProtein" "Cont_Q58D62" "Fetuin-B OS=Bos taurus OX=9913 GN=FETUB PE=1 SV=1" "0.000" "True" "3.526" "2" "1" "1" "1" "387" "42.6" "5.77" "2.90" "1" "other biological processes" "non-structural extracellular" "enzyme regulator activity" "Pf00031" "504615" "ENSBTAG00000017531" "FETUB" "bta:504615; Q58D62" "" "" "0" "0" "0.940" "0.832" "1.015" "1.342" "1.491" "1.304" "1.304" "1.578" "0.632" "116.7" "109.7" "97.1" "118.4" "156.6" "174.0" "152.2" "152.2" "184.1" "73.8" "" "" "" "" "" "" "" "" "" "" "61.8" "60.8" "55.6" "54.5" "84.7" "96.8" "89.5" "83.1" "103.3" "73.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4966290939603233061" "False" "High" "IsMasterProtein" "O00461" "Golgi integral membrane protein 4 OS=Homo sapiens OX=9606 GN=GOLIM4 PE=1 SV=1" "0.000" "False" "3.522" "2" "1" "1" "1" "696" "81.8" "4.77" "2.32" "1" "" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "" "27333" "ENSG00000173905" "GOLIM4" "hsa:27333; O00461" "" "Intra-Golgi traffic" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1684474116770674977" "False" "High" "IsMasterProtein" "Q9NW68" "BSD domain-containing protein 1 OS=Homo sapiens OX=9606 GN=BSDC1 PE=1 SV=1" "0.000" "False" "3.517" "2" "1" "1" "1" "430" "47.1" "4.49" "2.64" "1" "" "other cell component" "" "Pf03909" "55108" "ENSG00000160058" "BSDC1" "B4DMS7; B4DTI7; B4DTP7; B4E2X8; hsa:55108; Q49AT8; Q68DY6; Q6IAA3; Q6MZK1; Q6UXS1; Q9HAL9; Q9NW68" "" "" "0" "0" "1.188" "0.966" "0.857" "0.976" "1.054" "1.043" "1.096" "1.032" "0.836" "51.8" "61.5" "50.0" "44.4" "50.6" "54.6" "54.0" "56.8" "53.4" "43.3" "" "" "" "" "" "" "" "" "" "" "27.4" "34.1" "28.7" "20.4" "27.4" "30.4" "31.8" "31.0" "30.0" "43.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7694948017889393545" "False" "High" "IsMasterProtein" "Q8N490" "Probable hydrolase PNKD OS=Homo sapiens OX=9606 GN=PNKD PE=1 SV=2" "0.000" "False" "3.512" "4" "1" "1" "1" "385" "42.8" "9.09" "2.94" "1" "other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion;nucleus" "other molecular function" "Pf00753, Pf16123" "25953" "ENSG00000127838" "PNKD" "A8K1F2; hsa:25953; Q8N490; Q96A48; Q9BU26; Q9NSX4; Q9ULN6; Q9Y4T1" "Mitochondrial complex IV assembly" "" "1" "0" "1.327" "0.916" "1.070" "0.869" "1.027" "0.962" "0.813" "0.950" "0.973" "66.0" "87.6" "60.5" "70.7" "57.4" "67.8" "63.5" "53.7" "62.7" "64.3" "" "" "" "" "" "" "" "" "" "" "35.0" "48.6" "34.6" "32.5" "31.0" "37.7" "37.4" "29.3" "35.2" "64.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7347727386660618652" "False" "High" "IsMasterProtein" "Q8IUI8" "Cytokine receptor-like factor 3 OS=Homo sapiens OX=9606 GN=CRLF3 PE=1 SV=2" "0.000" "False" "3.512" "2" "1" "1" "1" "442" "49.7" "5.14" "2.68" "1" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "51379" "ENSG00000176390" "CRLF3" "A6NJF3; B2R8C3; hsa:51379; Q2MLY7; Q8IUI8; Q9UNI3; Q9Y6M8" "NF1 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1455362657326634232" "False" "High" "IsMasterProtein" "Q02543" "Large ribosomal subunit protein eL20 OS=Homo sapiens OX=9606 GN=RPL18A PE=1 SV=2" "0.000" "False" "3.510" "5" "1" "1" "1" "176" "20.7" "10.71" "2.96" "1" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01775" "6142" "ENSG00000105640" "RPL18A" "hsa:6142; Q02543" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "1.008" "1.074" "1.239" "1.001" "1.054" "0.903" "1.010" "0.868" "0.562" "367.0" "369.8" "394.2" "454.8" "367.5" "386.8" "331.4" "370.5" "318.7" "206.1" "" "" "" "" "" "" "" "" "" "" "194.3" "205.1" "225.7" "209.4" "198.8" "215.1" "195.0" "202.3" "178.8" "206.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2516940427401881470" "False" "High" "IsMasterProtein" "Q13615" "Myotubularin-related protein 3 OS=Homo sapiens OX=9606 GN=MTMR3 PE=1 SV=3" "0.000" "False" "3.507" "1" "1" "1" "1" "1198" "133.5" "5.80" "2.25" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;other cell component" "other molecular function" "Pf01363, Pf06602" "8897" "ENSG00000100330" "MTMR3" "A5PL26; A7MD32; hsa:8897; Q13615; Q9NYN5; Q9NYN6; Q9UDX6; Q9UEG3" "" "Synthesis of PIPs at the plasma membrane; Macroautophagy" "2" "0" "0.856" "0.953" "0.861" "0.851" "0.887" "0.965" "0.958" "0.882" "0.594" "106.9" "91.6" "101.9" "92.1" "91.0" "94.9" "103.1" "102.4" "94.3" "63.5" "" "" "" "" "" "" "" "" "" "" "56.6" "50.8" "58.3" "42.4" "49.2" "52.8" "60.7" "55.9" "52.9" "63.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1190496341580409730" "False" "High" "IsMasterProtein" "Q5TAX3" "Terminal uridylyltransferase 4 OS=Homo sapiens OX=9606 GN=TUT4 PE=1 SV=3" "0.000" "False" "3.505" "1" "2" "2" "2" "1644" "185.0" "7.97" "4.55" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00098, Pf01909, Pf03828, Pf19088" "23318" "ENSG00000134744" "TUT4" "A2RRP0; B7Z8J5; D3DQ35; hsa:23318; Q12764; Q5TAX2; Q5TAX3; Q5TAX4; Q86XZ3" "" "Zygotic genome activation (ZGA); Deadenylation of mRNA; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7480523710602738279" "False" "High" "IsMasterProtein" "Q9BPZ3" "Polyadenylate-binding protein-interacting protein 2 OS=Homo sapiens OX=9606 GN=PAIP2 PE=1 SV=1" "0.000" "False" "3.501" "6" "1" "1" "1" "127" "15.0" "4.12" "2.61" "1" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf07145" "51247" "ENSG00000120727" "PAIP2" "B2RBI1; D3DQC6; hsa:51247; Q49A06; Q9BPZ3; Q9H0Y5; Q9P0Q8" "" "" "0" "0" "1.160" "1.149" "1.229" "1.103" "1.093" "0.974" "1.071" "1.056" "1.264" "72.8" "84.5" "83.7" "89.5" "80.4" "79.6" "71.0" "78.0" "77.0" "92.1" "" "" "" "" "" "" "" "" "" "" "38.6" "46.8" "47.9" "41.2" "43.5" "44.3" "41.8" "42.6" "43.2" "92.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8194889804076803831" "False" "High" "IsMasterProtein" "Q9UBU9" "Nuclear RNA export factor 1 OS=Homo sapiens OX=9606 GN=NXF1 PE=1 SV=1" "0.000" "False" "3.492" "1" "1" "1" "1" "619" "70.1" "8.51" "3.09" "1" "other metabolic processes;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf02136, Pf03943, Pf09162" "10482" "ENSG00000162231" "NXF1" "B4E269; hsa:10482; Q99799; Q9UBU9; Q9UQL2" "mRNA processing" "Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2896751395551910999" "False" "High" "IsMasterProtein" "O95236" "Apolipoprotein L3 OS=Homo sapiens OX=9606 GN=APOL3 PE=1 SV=3" "0.000" "False" "3.480" "3" "1" "1" "1" "402" "44.3" "8.16" "2.40" "1" "protein metabolism;other metabolic processes;stress response;transport" "non-structural extracellular;other cell component" "transporter activity;other molecular function" "Pf05461" "80833" "ENSG00000128284" "APOL3" "B1AHI4; B1AHI5; hsa:80833; O95236; Q5U5N4; Q9BQ82; Q9BQA3" "" "" "0" "0" "1.247" "1.397" "1.299" "1.120" "1.330" "1.278" "1.324" "1.215" "1.828" "48.2" "60.1" "67.3" "62.6" "53.9" "64.1" "61.6" "63.8" "58.5" "88.0" "" "" "" "" "" "" "" "" "" "" "25.5" "33.3" "38.5" "28.8" "29.2" "35.6" "36.2" "34.8" "32.8" "88.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4738177424081249956" "False" "High" "IsMasterProtein" "Q8WWI1" "LIM domain only protein 7 OS=Homo sapiens OX=9606 GN=LMO7 PE=1 SV=3" "0.000" "False" "3.478" "1" "2" "2" "2" "1683" "192.6" "8.09" "4.28" "2" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00307, Pf00412, Pf00595, Pf15949" "4008" "ENSG00000136153" "LMO7" "E9PLH4; O15462; O95346; Q5TBK6; Q8WWI1; Q9UKC1; Q9UQM5; Q9Y6A7" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Signaling by ALK fusions and activated point mutants" "3" "0" "0.811" "0.884" "0.880" "1.040" "1.145" "1.541" "1.514" "1.475" "0.977" "82.1" "66.6" "72.6" "72.3" "85.3" "94.0" "126.5" "124.3" "121.0" "80.2" "" "" "" "" "" "" "" "" "" "" "43.5" "36.9" "41.6" "33.3" "46.2" "52.3" "74.5" "67.8" "67.9" "80.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2758038755542979545" "False" "High" "IsMasterProtein" "P61769" "Beta-2-microglobulin OS=Homo sapiens OX=9606 GN=B2M PE=1 SV=1" "0.000" "False" "3.472" "8" "1" "1" "1" "119" "13.7" "6.52" "2.53" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07654" "567" "ENSG00000166710; ENSG00000273686" "B2M" "hsa:567; P01884; P61769; Q540F8; Q6IAT8; Q9UCK0; Q9UD48; Q9UDF4" "IL-18 signaling pathway" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; DAP12 signaling; Neutrophil degranulation; ER-Phagosome pathway; Amyloid fiber formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Modulation by Mtb of host immune system; Nef mediated downregulation of MHC class I complex cell surface expression; Endosomal/Vacuolar pathway" "13" "0" "0.759" "0.878" "0.942" "0.804" "0.984" "0.835" "0.898" "0.808" "0.541" "197.5" "149.9" "173.4" "186.1" "158.7" "194.3" "165.0" "177.4" "159.6" "106.8" "" "" "" "" "" "" "" "" "" "" "104.6" "83.1" "99.3" "85.7" "85.9" "108.1" "97.1" "96.8" "89.5" "106.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2926679715344885449" "False" "High" "IsMasterProtein" "O94913" "Pre-mRNA cleavage complex 2 protein Pcf11 OS=Homo sapiens OX=9606 GN=PCF11 PE=1 SV=3" "0.000" "False" "3.471" "1" "2" "2" "2" "1555" "172.9" "8.48" "2.33" "2" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04818, Pf11526, Pf20827, Pf20844, Pf20845" "51585" "ENSG00000165494" "PCF11" "A6H8W7; hsa:51585; O43671; O94913; Q6P0X8" "" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; RNA polymerase II transcribes snRNA genes; Processing of Intronless Pre-mRNAs" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8027641362663373540" "False" "High" "IsMasterProtein" "Q9NQE9" "Adenosine 5'-monophosphoramidase HINT3 OS=Homo sapiens OX=9606 GN=HINT3 PE=1 SV=1" "0.000" "False" "3.467" "5" "1" "1" "1" "182" "20.3" "6.60" "2.13" "1" "" "nucleus;other cell component" "other molecular function" "Pf11969" "135114" "ENSG00000111911" "HINT3" "B3KQ91; hsa:135114; Q8N0Y9; Q9NQE9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9099132526023132947" "False" "High" "IsMasterProtein" "Q9Y6D5" "Brefeldin A-inhibited guanine nucleotide-exchange protein 2 OS=Homo sapiens OX=9606 GN=ARFGEF2 PE=1 SV=3" "0.000" "False" "3.466" "1" "2" "2" "2" "1785" "201.9" "6.33" "2.16" "2" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf01369, Pf09324, Pf12783, Pf16213, Pf20252" "10564" "ENSG00000124198" "ARFGEF2" "hsa:10564; Q5TFT9; Q9NTS1; Q9Y6D5" "" "Association of TriC/CCT with target proteins during biosynthesis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1011365371626777610" "False" "High" "IsMasterProtein" "P56277" "Cx9C motif-containing protein 4 OS=Homo sapiens OX=9606 GN=CMC4 PE=1 SV=1" "0.000" "False" "3.460" "12" "1" "1" "1" "68" "7.7" "8.18" "3.73" "1" "" "mitochondrion" "" "Pf08991" "100272147" "ENSG00000182712" "CMC4" "hsa:100272147; P56277; Q5HYP9" "" "Mitochondrial protein import" "1" "0" "0.928" "1.108" "0.961" "0.890" "0.889" "0.941" "0.930" "0.921" "0.418" "273.7" "253.9" "303.4" "263.0" "243.7" "243.4" "257.5" "254.7" "252.0" "114.4" "" "" "" "" "" "" "" "" "" "" "144.9" "140.8" "173.7" "121.1" "131.8" "135.4" "151.6" "139.0" "141.4" "114.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8065453246646173554" "False" "High" "IsMasterProtein" "O15231" "Zinc finger protein 185 OS=Homo sapiens OX=9606 GN=ZNF185 PE=1 SV=3" "0.001" "False" "3.452" "3" "2" "3" "2" "689" "73.5" "7.01" "6.41" "2" "" "cytoskeleton;other cell component" "other molecular function" "" "7739" "ENSG00000147394; ENSG00000292196" "ZNF185" "A4FTV3; A6NME5; B4DLE9; B7Z771; B8K2L9; B8K2M0; B8K2M1; B8K2M2; E9PFR6; F5GXF7; F5GZL4; F8W8V7; H0Y4M8; hsa:7739; O00345; O15231; Q8N1R8; Q9NSD2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "514101839783017752" "False" "High" "IsMasterProtein" "Q9P021" "Cysteine-rich PDZ-binding protein OS=Homo sapiens OX=9606 GN=CRIPT PE=1 SV=1" "0.001" "False" "3.451" "8" "1" "1" "1" "101" "11.2" "9.47" "3.09" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf10235" "9419" "ENSG00000119878" "CRIPT" "hsa:9419; Q9P021" "" "" "0" "0" "1.161" "1.417" "1.358" "0.737" "0.768" "0.730" "1.180" "0.781" "0.462" "140.3" "162.9" "198.8" "190.5" "103.3" "107.8" "102.4" "165.5" "109.6" "64.9" "" "" "" "" "" "" "" "" "" "" "74.3" "90.3" "113.8" "87.7" "55.9" "59.9" "60.3" "90.3" "61.5" "64.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4381387929152042020" "False" "High" "IsMasterProtein" "Q9ULX3" "RNA-binding protein NOB1 OS=Homo sapiens OX=9606 GN=NOB1 PE=1 SV=1" "0.001" "False" "3.449" "3" "2" "2" "2" "412" "46.6" "7.18" "4.87" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08772, Pf15017, Pf17146" "28987" "ENSG00000141101" "NOB1" "hsa:28987; Q7L6B7; Q7M4M4; Q7Z4B5; Q9NWB0; Q9ULX3" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.044" "1.033" "1.087" "0.987" "1.016" "0.856" "0.842" "0.934" "2.482" "181.2" "189.1" "187.2" "197.0" "178.9" "184.1" "155.1" "152.6" "169.2" "449.7" "" "" "" "" "" "" "" "" "" "" "96.0" "104.8" "107.2" "90.7" "96.8" "102.4" "91.3" "83.3" "94.9" "449.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7691749111498675631" "False" "High" "IsMasterProtein" "O14531" "Dihydropyrimidinase-related protein 4 OS=Homo sapiens OX=9606 GN=DPYSL4 PE=1 SV=2" "0.001" "False" "3.444" "3" "1" "2" "1" "572" "61.8" "7.09" "5.12" "1" "developmental processes" "cytosol" "cytoskeletal activity;other molecular function" "Pf01979" "10570" "ENSG00000151640" "DPYSL4" "B2RMQ1; D3DRG5; hsa:10570; O00240; O14531; Q5T0Q7" "" "CRMPs in Sema3A signaling" "1" "0" "1.188" "1.058" "1.122" "1.080" "1.229" "1.162" "0.987" "1.066" "1.937" "106.6" "126.6" "112.7" "119.6" "115.1" "130.9" "123.8" "105.2" "113.6" "206.4" "" "" "" "" "" "" "" "" "" "" "56.4" "70.2" "64.5" "55.1" "62.3" "72.8" "72.9" "57.4" "63.7" "206.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4405181458594490981" "False" "High" "IsMasterProtein" "Q9NYL2" "Mitogen-activated protein kinase kinase kinase 20 OS=Homo sapiens OX=9606 GN=MAP3K20 PE=1 SV=3" "0.001" "False" "3.444" "1" "1" "1" "1" "800" "91.1" "7.87" "3.01" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;translation activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00536, Pf07714" "51776" "ENSG00000091436" "MAP3K20" "B3KPG2; hsa:51776; Q53SX1; Q580W8; Q59GY5; Q86YW8; Q9HCC4; Q9HCC5; Q9HDD2; Q9NYE9; Q9NYL2" "MAPK signaling pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2869722740218249638" "False" "High" "IsMasterProtein" "Q9Y6M4" "Casein kinase I isoform gamma-3 OS=Homo sapiens OX=9606 GN=CSNK1G3 PE=1 SV=2" "0.001" "False" "3.440" "2" "1" "1" "1" "447" "51.4" "9.22" "2.73" "1" "cell-cell signaling;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12605" "1456" "ENSG00000151292" "CSNK1G3" "A8K040; B4DSH2; B7Z9Q4; E7EVD0; hsa:1456; Q86WZ7; Q9Y6M3; Q9Y6M4" "Hedgehog signaling pathway" "" "1" "0" "0.975" "0.923" "1.034" "1.120" "0.978" "0.996" "0.917" "0.819" "0.624" "90.9" "88.6" "83.9" "94.0" "101.8" "88.8" "90.5" "83.3" "74.4" "56.7" "" "" "" "" "" "" "" "" "" "" "48.1" "49.1" "48.0" "43.3" "55.1" "49.4" "53.3" "45.5" "41.7" "56.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2508229497243424265" "False" "High" "IsMasterProtein" "P82673" "Small ribosomal subunit protein mS35 OS=Homo sapiens OX=9606 GN=MRPS35 PE=1 SV=1" "0.001" "False" "3.438" "5" "2" "3" "2" "323" "36.8" "8.24" "4.90" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf10213" "60488" "ENSG00000061794" "MRPS35" "hsa:60488; P82673; Q32LZ1; Q6P4C6; Q7L1M6; Q8NBP4; Q96AI0; Q9H044; Q9HC14; Q9P1R5" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.084" "1.016" "1.136" "0.983" "1.007" "0.977" "0.871" "0.975" "2.442" "342.8" "371.6" "348.4" "389.4" "337.1" "345.3" "335.0" "298.7" "334.1" "837.1" "" "" "" "" "" "" "" "" "" "" "181.5" "206.0" "199.5" "179.3" "182.4" "192.1" "197.2" "163.0" "187.4" "837.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8766767178054047588" "False" "High" "IsMasterProtein" "Q9BYC9" "Large ribosomal subunit protein bL20m OS=Homo sapiens OX=9606 GN=MRPL20 PE=1 SV=1" "0.001" "False" "3.425" "5" "1" "2" "1" "149" "17.4" "10.86" "5.66" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00453" "55052" "ENSG00000242485" "MRPL20" "B2RE41; B7Z746; hsa:55052; Q9BYC9" "1p36 copy number variation syndrome" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8900413936480429684" "False" "High" "IsMasterProtein" "Q9Y6I4" "Ubiquitin carboxyl-terminal hydrolase 3 OS=Homo sapiens OX=9606 GN=USP3 PE=1 SV=2" "0.001" "False" "3.420" "2" "1" "1" "1" "520" "58.9" "8.18" "2.70" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00443, Pf02148" "9960" "ENSG00000140455" "USP3" "B4DVU5; F5H1A6; hsa:9960; Q8WVD0; Q9Y6I4" "" "Ub-specific processing proteases" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1696656026908675474" "False" "High" "IsMasterProtein" "Q9BS40" "Latexin OS=Homo sapiens OX=9606 GN=LXN PE=1 SV=2" "0.001" "False" "3.418" "5" "1" "1" "1" "222" "25.7" "5.78" "2.06" "1" "stress response;other biological processes" "non-structural extracellular;other cell component" "enzyme regulator activity;other molecular function" "Pf06907, Pf20630" "56925" "ENSG00000079257" "LXN" "hsa:56925; Q96PN2; Q9BS40; Q9NQS6" "" "" "0" "0" "0.946" "1.005" "1.068" "0.997" "1.046" "1.103" "1.064" "0.888" "0.947" "127.8" "120.9" "128.5" "136.5" "127.5" "133.7" "141.0" "136.0" "113.6" "121.0" "" "" "" "" "" "" "" "" "" "" "67.7" "67.1" "73.6" "62.9" "69.0" "74.3" "83.0" "74.2" "63.7" "121.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-173769377935829106" "False" "High" "IsMasterProtein" "Cont_P15497" "Apolipoprotein A-I OS=Bos taurus OX=9913 GN=APOA1 PE=1 SV=3" "0.001" "True" "3.415" "3" "1" "1" "1" "265" "30.3" "5.97" "3.08" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;other molecular function" "Pf01442" "281631" "ENSBIXG00000010441; ENSBIXG00005004093; ENSBTAG00000002258" "APOA1" "A0A4W2DWW2; A5D7M9; bta:281631; P15497; Q3SZD9; V6F9A2" "Statin pathway; Folate metabolism; Vitamin B12 metabolism; Selenium micronutrient network" "Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Chylomicron assembly; Chylomicron remodeling; HDL remodeling; Retinoid metabolism and transport; HDL clearance; HDL assembly; Heme signaling; Scavenging by Class B Receptors" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "115101743397248701" "False" "High" "IsMasterProtein" "Q15528" "Mediator of RNA polymerase II transcription subunit 22 OS=Homo sapiens OX=9606 GN=MED22 PE=1 SV=2" "0.001" "False" "3.413" "5" "1" "1" "1" "200" "22.2" "4.68" "3.16" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf06179" "6837" "ENSG00000148297; ENSG00000281022" "MED22" "B3KW83; B3KWX4; hsa:6837; O76072; Q15528; Q5T8U0" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "3" "0" "1.066" "1.005" "1.042" "0.905" "0.986" "0.860" "0.836" "0.940" "1.311" "259.3" "276.4" "260.6" "270.3" "234.6" "255.7" "223.0" "216.7" "243.6" "340.0" "" "" "" "" "" "" "" "" "" "" "137.3" "153.2" "149.2" "124.5" "126.9" "142.3" "131.2" "118.3" "136.7" "340.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4410933930265088231" "False" "High" "IsMasterProtein" "P14927" "Cytochrome b-c1 complex subunit 7 OS=Homo sapiens OX=9606 GN=UQCRB PE=1 SV=2" "0.001" "False" "3.410" "9" "1" "1" "1" "111" "13.5" "8.78" "3.11" "1" "other metabolic processes" "other membranes;mitochondrion" "" "Pf02271" "7381" "ENSG00000156467" "UQCRB" "E5RJU0; hsa:7381; P14927; Q6FGD1" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "Respiratory electron transport" "4" "0" "1.005" "1.068" "1.005" "1.006" "0.956" "0.925" "1.048" "0.781" "0.576" "289.0" "290.3" "308.7" "290.4" "290.6" "276.3" "267.2" "302.9" "225.7" "166.5" "" "" "" "" "" "" "" "" "" "" "153.0" "161.0" "176.8" "133.7" "157.2" "153.7" "157.3" "165.4" "126.6" "166.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8213530415283437885" "False" "High" "IsMasterProtein" "Q9Y2R0" "Cytochrome c oxidase assembly factor 3 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=COA3 PE=1 SV=1" "0.001" "False" "3.407" "8" "1" "1" "1" "106" "11.7" "9.60" "4.01" "1" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "" "Pf09813" "28958" "ENSG00000183978" "COA3" "A8K498; hsa:28958; Q9Y2R0" "Mitochondrial complex IV assembly; Arsenic metabolism and reactive oxygen species generation" "" "2" "0" "0.949" "0.993" "1.050" "1.066" "0.967" "0.822" "0.996" "1.146" "0.425" "80.5" "76.4" "79.9" "84.5" "85.8" "77.8" "66.1" "80.1" "92.2" "34.2" "" "" "" "" "" "" "" "" "" "" "42.6" "42.3" "45.8" "38.9" "46.4" "43.3" "38.9" "43.7" "51.7" "34.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4549685978582378632" "False" "High" "IsMasterProtein" "Q9Y399" "Small ribosomal subunit protein uS2m OS=Homo sapiens OX=9606 GN=MRPS2 PE=1 SV=1" "0.001" "False" "3.402" "5" "2" "2" "2" "296" "33.2" "9.26" "4.16" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00318" "51116" "ENSG00000122140" "MRPS2" "hsa:51116; Q5T899; Q9BSQ4; Q9Y399" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination; Mitochondrial protein degradation" "4" "0" "0.837" "1.258" "1.146" "1.148" "1.213" "1.250" "0.745" "1.232" "3.628" "45.8" "38.3" "57.5" "52.4" "52.5" "55.5" "57.2" "34.1" "56.3" "166.0" "" "" "" "" "" "" "" "" "" "" "24.2" "21.2" "33.0" "24.1" "28.4" "30.9" "33.6" "18.6" "31.6" "166.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1639956808395934598" "False" "High" "IsMasterProtein" "Q9UKT4" "F-box only protein 5 OS=Homo sapiens OX=9606 GN=FBXO5 PE=1 SV=1" "0.001" "False" "3.394" "2" "1" "1" "1" "447" "50.1" "8.92" "2.63" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00646" "26271" "ENSG00000112029" "FBXO5" "B3KNX5; hsa:26271; Q5TF47; Q8WV29; Q9UGC8; Q9UKT4" "" "SCF-beta-TrCP mediated degradation of Emi1; G1/S-Specific Transcription; Phosphorylation of Emi1; Mitotic Metaphase/Anaphase Transition" "5" "0" "0.877" "1.006" "0.799" "0.925" "0.811" "0.856" "0.937" "0.988" "1.157" "85.9" "75.4" "86.4" "68.6" "79.4" "69.7" "73.5" "80.5" "84.9" "99.4" "" "" "" "" "" "" "" "" "" "" "45.5" "41.8" "49.5" "31.6" "43.0" "38.7" "43.3" "43.9" "47.6" "99.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1537630137721928118" "False" "High" "IsMasterProtein" "Q8IU60" "m7GpppN-mRNA hydrolase OS=Homo sapiens OX=9606 GN=DCP2 PE=1 SV=3" "0.001" "False" "3.391" "2" "1" "1" "1" "420" "48.4" "8.00" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293, Pf05026" "167227" "ENSG00000172795" "DCP2" "C9J778; hsa:167227; Q6P2D4; Q7Z5W5; Q8IU60; Q8NBG5" "" "mRNA decay by 5' to 3' exoribonuclease; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4954031466942572679" "False" "High" "IsMasterProtein" "Q6NW29" "RWD domain-containing protein 4 OS=Homo sapiens OX=9606 GN=RWDD4 PE=1 SV=3" "0.001" "False" "3.391" "5" "1" "1" "1" "188" "21.2" "5.31" "2.65" "1" "" "" "" "Pf05773" "201965" "ENSG00000182552" "RWDD4" "B2RDE9; B4DDP2; hsa:201965; Q6NW29; Q75LA9; Q8WVW2" "" "" "0" "0" "0.897" "1.062" "1.323" "1.082" "1.154" "0.910" "0.669" "1.161" "3.633" "47.4" "42.5" "50.3" "62.6" "51.3" "54.7" "43.1" "31.7" "55.0" "172.1" "" "" "" "" "" "" "" "" "" "" "25.1" "23.5" "28.8" "28.8" "27.7" "30.4" "25.4" "17.3" "30.8" "172.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7714600249941919632" "False" "High" "IsMasterProtein" "O95562" "Vesicle transport protein SFT2B OS=Homo sapiens OX=9606 GN=SFT2D2 PE=1 SV=1" "0.001" "False" "3.389" "6" "1" "2" "1" "160" "17.8" "9.13" "5.32" "1" "transport" "other membranes" "" "Pf04178" "375035" "ENSG00000213064" "SFT2D2" "A8K2R0; hsa:375035; O95562; Q6UWR8" "TYROBP causal network in microglia" "" "1" "0" "1.030" "0.982" "1.078" "1.046" "0.887" "0.953" "1.028" "1.047" "0.777" "114.8" "118.2" "112.7" "123.8" "120.1" "101.8" "109.4" "118.0" "120.2" "89.2" "" "" "" "" "" "" "" "" "" "" "60.8" "65.5" "64.6" "57.0" "65.0" "56.6" "64.4" "64.4" "67.4" "89.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5777043105444546084" "False" "High" "IsMasterProtein" "P00387" "NADH-cytochrome b5 reductase 3 OS=Homo sapiens OX=9606 GN=CYB5R3 PE=1 SV=3" "0.001" "False" "3.385" "4" "1" "1" "1" "301" "34.2" "7.59" "3.15" "1" "other metabolic processes;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00175, Pf00970" "1727" "ENSG00000100243" "CYB5R3" "B1AHF2; B7Z7L3; hsa:1727; O75675; P00387; Q8TDL8; Q8WTS8; Q9UEN4; Q9UEN5; Q9UL55; Q9UL56" "Oxidation by cytochrome P450" "Neutrophil degranulation; Phase I - Functionalization of compounds; Vitamin C (ascorbate) metabolism" "4" "0" "0.837" "0.867" "0.995" "0.905" "0.956" "0.960" "0.975" "0.888" "0.741" "51.1" "42.7" "44.3" "50.8" "46.2" "48.9" "49.0" "49.8" "45.4" "37.8" "" "" "" "" "" "" "" "" "" "" "27.1" "23.7" "25.4" "23.4" "25.0" "27.2" "28.9" "27.2" "25.4" "37.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1411414456407117859" "False" "High" "IsMasterProtein" "Q7Z6K3" "Protein prenyltransferase alpha subunit repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=PTAR1 PE=1 SV=2" "0.001" "False" "3.383" "2" "1" "1" "1" "402" "46.4" "6.99" "3.31" "1" "" "other cell component" "other molecular function" "Pf01239" "375743" "ENSG00000188647" "PTAR1" "hsa:375743; Q5T7V5; Q5T7V6; Q7Z6K3" "" "" "0" "0" "1.004" "0.948" "1.071" "0.998" "0.964" "0.804" "0.829" "0.807" "0.714" "197.5" "198.2" "187.1" "211.5" "197.1" "190.5" "158.7" "163.7" "159.3" "141.0" "" "" "" "" "" "" "" "" "" "" "104.6" "109.9" "107.2" "97.4" "106.6" "105.9" "93.4" "89.4" "89.3" "141.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3766879511259281877" "False" "High" "IsMasterProtein" "Q96CM8" "Medium-chain acyl-CoA ligase ACSF2, mitochondrial OS=Homo sapiens OX=9606 GN=ACSF2 PE=1 SV=2" "0.001" "False" "3.375" "3" "2" "3" "2" "615" "68.1" "7.55" "4.88" "2" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00501, Pf13193" "80221" "ENSG00000167107" "ACSF2" "B4DFQ6; B4DHT5; B4DUF5; hsa:80221; Q96CM8; Q9H7G2" "Mitochondrial long chain fatty acid beta-oxidation; Mitochondrial fatty acid oxidation disorders" "Mitochondrial Fatty Acid Beta-Oxidation" "3" "0" "1.192" "1.126" "1.140" "1.200" "1.265" "1.236" "1.020" "1.203" "1.420" "105.0" "125.1" "118.1" "119.6" "125.9" "132.8" "129.8" "107.0" "126.3" "149.0" "" "" "" "" "" "" "" "" "" "" "55.6" "69.3" "67.7" "55.1" "68.1" "73.9" "76.4" "58.4" "70.8" "149.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8961190954250988131" "False" "High" "IsMasterProtein" "Q16891" "MICOS complex subunit MIC60 OS=Homo sapiens OX=9606 GN=IMMT PE=1 SV=1" "0.001" "False" "3.373" "2" "2" "2" "2" "758" "83.6" "6.48" "5.00" "2" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "" "Pf09731" "10989" "ENSG00000132305" "IMMT" "B1H0U5; B2R5N6; hsa:10989; Q14539; Q15092; Q16891; Q68D41; Q69HW5; Q6IBL0; Q7Z3X1; Q8TAJ5; Q9P0V2" "" "Cristae formation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3771039295331557619" "False" "High" "IsMasterProtein" "P12694" "2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=BCKDHA PE=1 SV=2" "0.001" "False" "3.369" "2" "1" "1" "1" "445" "50.4" "8.27" "2.21" "1" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00676" "593" "ENSG00000248098" "BCKDHA" "B4DP47; E7EW46; hsa:593; P12694; Q16034; Q16472" "Lipid metabolism pathway" "Glyoxylate metabolism and glycine degradation; Branched-chain amino acid catabolism" "3" "0" "0.994" "0.920" "0.982" "0.879" "0.957" "0.915" "0.827" "0.756" "0.571" "207.8" "206.5" "191.2" "204.1" "182.5" "198.9" "190.0" "171.8" "157.0" "118.7" "" "" "" "" "" "" "" "" "" "" "110.0" "114.5" "109.5" "94.0" "98.8" "110.6" "111.8" "93.8" "88.1" "118.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6309414575858280989" "False" "High" "IsMasterProtein" "Q9GZQ3" "COMM domain-containing protein 5 OS=Homo sapiens OX=9606 GN=COMMD5 PE=1 SV=1" "0.001" "False" "3.356" "7" "2" "3" "2" "224" "24.7" "7.02" "6.60" "2" "" "cytosol;nucleus" "" "Pf07258, Pf21672" "28991" "ENSG00000170619" "COMMD5" "D3DWN7; hsa:28991; Q9GZQ3; Q9NVN6; Q9UHX5" "" "Neddylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6991992927110115551" "False" "High" "IsMasterProtein" "Q99504" "Eyes absent homolog 3 OS=Homo sapiens OX=9606 GN=EYA3 PE=1 SV=3" "0.001" "False" "3.353" "3" "1" "1" "1" "573" "62.6" "5.21" "0.00" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00702" "2140" "ENSG00000158161" "EYA3" "A8K190; B4DIR7; B4DNZ7; hsa:2140; O95463; Q8IVX7; Q99504; Q99813" "" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" "1" "0" "1.251" "1.091" "0.799" "1.103" "1.129" "1.097" "0.800" "1.204" "2.363" "31.9" "39.9" "34.8" "25.5" "35.2" "36.0" "35.0" "25.5" "38.4" "75.4" "" "" "" "" "" "" "" "" "" "" "16.9" "22.1" "19.9" "11.7" "19.0" "20.0" "20.6" "13.9" "21.6" "75.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1530095289376032453" "False" "High" "IsMasterProtein" "Q9HBH1" "Peptide deformylase, mitochondrial OS=Homo sapiens OX=9606 GN=PDF PE=1 SV=1" "0.001" "False" "3.350" "7" "2" "3" "2" "243" "27.0" "9.16" "8.24" "2" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf01327" "64146" "ENSG00000258429" "PDF" "hsa:64146; Q8WUN6; Q9HBH1" "" "" "0" "0" "1.034" "1.011" "0.999" "0.922" "1.018" "0.936" "0.949" "0.889" "0.610" "525.3" "543.1" "531.1" "524.7" "484.3" "535.0" "491.8" "498.3" "466.7" "320.6" "" "" "" "" "" "" "" "" "" "" "278.1" "301.1" "304.2" "241.7" "262.0" "297.6" "289.5" "272.0" "261.8" "320.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4962513167934133051" "False" "High" "IsMasterProtein" "P49643" "DNA primase large subunit OS=Homo sapiens OX=9606 GN=PRIM2 PE=1 SV=2" "0.001" "False" "3.348" "2" "1" "1" "1" "509" "58.8" "7.91" "2.56" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf04104" "5558" "ENSG00000146143" "PRIM2" "hsa:5558; P49643; Q53FJ8; Q6P1Q7; Q8WVL2; Q9H413" "Pyrimidine metabolism; G1 to S cell cycle control; DNA replication" "Activation of the pre-replicative complex; Polymerase switching on the C-strand of the telomere; Polymerase switching; Defective pyroptosis; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Telomere C-strand synthesis initiation; DNA replication initiation; Removal of the Flap Intermediate" "12" "0" "1.317" "1.062" "0.937" "1.098" "1.030" "1.003" "0.447" "0.879" "5.094" "30.7" "40.5" "32.6" "28.8" "33.7" "31.6" "30.8" "13.7" "27.0" "156.4" "" "" "" "" "" "" "" "" "" "" "16.3" "22.4" "18.7" "13.2" "18.2" "17.6" "18.1" "7.5" "15.1" "156.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1438891196455375570" "False" "High" "IsMasterProtein" "A9UHW6" "MIF4G domain-containing protein OS=Homo sapiens OX=9606 GN=MIF4GD PE=1 SV=1" "0.001" "False" "3.347" "7" "2" "2" "2" "222" "25.4" "5.33" "4.67" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02854" "57409" "ENSG00000125457" "MIF4GD" "A9UHW6; B4DUM7; hsa:57409; Q8N4Q5; Q9HBL5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7842122085258800044" "False" "High" "IsMasterProtein" "Q9BVM4" "Gamma-glutamylaminecyclotransferase OS=Homo sapiens OX=9606 GN=GGACT PE=1 SV=2" "0.001" "False" "3.345" "7" "1" "1" "1" "153" "17.3" "6.87" "2.23" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf06094" "87769" "ENSG00000134864" "GGACT" "B3KTN1; hsa:87769; Q9BT41; Q9BVM4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4672476971480337418" "False" "High" "IsMasterProtein" "P67870" "Casein kinase II subunit beta OS=Homo sapiens OX=9606 GN=CSNK2B PE=1 SV=1" "0.001" "False" "3.342" "4" "1" "1" "1" "215" "24.9" "5.55" "4.12" "1" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf01214" "1460" "ENSG00000204435; ENSG00000206406; ENSG00000224398; ENSG00000224774; ENSG00000228875; ENSG00000230700; ENSG00000232960" "CSNK2B" "B0UXA9; hsa:1460; P07312; P13862; P67870; Q4VX47" "Alzheimer's disease and miRNA effects; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Measles virus infection; Pleural mesothelioma; Alzheimer's disease; HDAC6 interactions in the central nervous system" "Condensation of Prometaphase Chromosomes; KEAP1-NFE2L2 pathway; Neutrophil degranulation; Regulation of PTEN stability and activity; Regulation of TP53 Activity through Phosphorylation; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Maturation of hRSV A proteins; Receptor Mediated Mitophagy; Synthesis of PC" "21" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4837224883862522345" "False" "High" "IsMasterProtein" "Q9BYD1" "Large ribosomal subunit protein uL13m OS=Homo sapiens OX=9606 GN=MRPL13 PE=1 SV=1" "0.001" "False" "3.338" "6" "1" "1" "1" "178" "20.7" "9.16" "3.09" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00572" "28998" "ENSG00000172172" "MRPL13" "B2R4R8; hsa:28998; Q9BYD1; Q9UI04" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.900" "1.050" "0.990" "1.055" "1.144" "0.851" "0.634" "0.800" "1.196" "71.1" "64.0" "74.7" "70.4" "75.0" "81.4" "60.6" "45.1" "56.9" "85.1" "" "" "" "" "" "" "" "" "" "" "37.7" "35.5" "42.8" "32.4" "40.6" "45.3" "35.6" "24.6" "31.9" "85.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2217826250867961619" "False" "High" "IsMasterProtein" "Q6P4F2" "Ferredoxin-2, mitochondrial OS=Homo sapiens OX=9606 GN=FDX2 PE=1 SV=3" "0.001" "False" "3.330" "6" "1" "1" "1" "183" "19.5" "5.38" "3.35" "1" "cell organization and biogenesis;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00111" "112812" "ENSG00000267673" "FDX2" "B7Z6L7; Q6P4F2; Q8N8B8" "" "Endogenous sterols; Pregnenolone biosynthesis; Defective CYP11A1 causes AICSR; Electron transport from NADPH to Ferredoxin" "5" "0" "1.082" "1.076" "1.205" "1.133" "0.849" "1.068" "1.116" "0.958" "0.795" "53.0" "57.3" "57.0" "63.8" "60.0" "45.0" "56.6" "59.1" "50.8" "42.1" "" "" "" "" "" "" "" "" "" "" "28.1" "31.8" "32.7" "29.4" "32.5" "25.0" "33.3" "32.3" "28.5" "42.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "407344682093019997" "False" "High" "IsMasterProtein" "Q53GL0" "Pleckstrin homology domain-containing family O member 1 OS=Homo sapiens OX=9606 GN=PLEKHO1 PE=1 SV=2" "0.001" "False" "3.325" "4" "1" "1" "1" "409" "46.2" "8.82" "0.00" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "" "Pf00169" "51177" "ENSG00000023902" "PLEKHO1" "hsa:51177; Q336K5; Q53GL0; Q8IZ51; Q9NRV3; Q9UL48" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3715584417028259664" "False" "High" "IsMasterProtein" "P56381" "ATP synthase subunit epsilon, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1E PE=1 SV=2" "0.001" "False" "3.312" "29" "2" "2" "2" "51" "5.8" "9.92" "5.68" "2" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf04627" "514" "ENSG00000124172" "ATP5F1E" "B2RDD0; E1P5H6; hsa:514; P56381; Q53XU6" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "Cristae formation; Formation of ATP by chemiosmotic coupling" "5" "0" "0.867" "1.051" "0.792" "0.990" "1.090" "0.991" "1.131" "1.025" "0.785" "283.6" "245.8" "298.0" "224.6" "280.8" "309.1" "280.9" "320.8" "290.6" "222.6" "" "" "" "" "" "" "" "" "" "" "150.1" "136.3" "170.7" "103.5" "151.9" "171.9" "165.3" "175.1" "163.0" "222.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "567113707807287491" "False" "High" "IsMasterProtein" "Q8NBT2" "Kinetochore protein Spc24 OS=Homo sapiens OX=9606 GN=SPC24 PE=1 SV=3" "0.001" "False" "3.312" "4" "1" "1" "1" "197" "22.4" "4.70" "3.05" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf08286" "147841" "ENSG00000161888" "SPC24" "B4DZZ7; C9JGC4; hsa:147841; Q8NBT2" "" "Separation of Sister Chromatids; RHO GTPases Activate Formins; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "1.069" "0.947" "0.989" "1.011" "1.010" "1.104" "0.928" "0.963" "3.178" "177.0" "189.3" "167.7" "175.1" "179.0" "178.8" "195.4" "164.4" "170.5" "562.6" "" "" "" "" "" "" "" "" "" "" "93.7" "105.0" "96.0" "80.7" "96.9" "99.4" "115.0" "89.7" "95.6" "562.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3610986345004973856" "False" "High" "IsMasterProtein" "P82664" "Small ribosomal subunit protein uS10m OS=Homo sapiens OX=9606 GN=MRPS10 PE=1 SV=2" "0.001" "False" "3.310" "5" "1" "1" "1" "201" "23.0" "8.00" "2.72" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf00338" "55173" "ENSG00000048544" "MRPS10" "B2RE89; hsa:55173; P82664; Q9H3E5; Q9NVR3" "" "Mitochondrial translation elongation; Mitochondrial protein degradation; Mitochondrial translation initiation; Mitochondrial translation termination" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3476317971320699033" "False" "High" "IsMasterProtein" "O43156" "TELO2-interacting protein 1 homolog OS=Homo sapiens OX=9606 GN=TTI1 PE=1 SV=3" "0.001" "False" "3.301" "1" "1" "1" "1" "1089" "122.0" "5.97" "2.61" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf21547" "9675" "ENSG00000101407" "TTI1" "D6W4K3; hsa:9675; O43156; Q5JX67; Q96A38; Q9BR47; Q9H4K0" "Fragile X syndrome; Pleural mesothelioma" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1756983135160374971" "False" "High" "IsMasterProtein" "Q8NBJ5" "Procollagen galactosyltransferase 1 OS=Homo sapiens OX=9606 GN=COLGALT1 PE=1 SV=1" "0.001" "False" "3.298" "2" "1" "1" "1" "622" "71.6" "7.31" "2.22" "1" "cell organization and biogenesis;other biological processes" "ER/Golgi" "other molecular function" "Pf01755, Pf13704" "79709" "ENSG00000130309" "COLGALT1" "hsa:79709; Q8NBJ5; Q8NC64" "Type I collagen synthesis in the context of osteogenesis imperfecta" "Collagen biosynthesis and modifying enzymes" "2" "0" "0.964" "0.800" "0.757" "0.899" "0.665" "0.721" "0.758" "0.733" "1.868" "44.8" "43.1" "35.8" "33.9" "40.2" "29.8" "32.3" "33.9" "32.8" "83.6" "" "" "" "" "" "" "" "" "" "" "23.7" "23.9" "20.5" "15.6" "21.8" "16.6" "19.0" "18.5" "18.4" "83.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2556880978610824670" "False" "High" "IsMasterProtein" "P62256" "Ubiquitin-conjugating enzyme E2 H OS=Homo sapiens OX=9606 GN=UBE2H PE=1 SV=1" "0.001" "False" "3.298" "4" "1" "1" "1" "183" "20.6" "4.67" "3.35" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00179" "7328" "ENSG00000186591" "UBE2H" "A4D1L6; C9JY93; hsa:7328; P37286; P62256; Q7Z6F4" "Ciliary landscape" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "3" "0" "1.032" "1.034" "0.975" "1.099" "1.034" "1.076" "1.120" "1.225" "0.923" "280.6" "289.4" "290.0" "273.5" "308.4" "290.0" "301.8" "314.2" "343.6" "259.0" "" "" "" "" "" "" "" "" "" "" "148.6" "160.4" "166.1" "125.9" "166.8" "161.3" "177.6" "171.5" "192.8" "259.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2292330841191308535" "False" "High" "IsMasterProtein" "O75420" "GRB10-interacting GYF protein 1 OS=Homo sapiens OX=9606 GN=GIGYF1 PE=1 SV=2" "0.001" "False" "3.295" "1" "1" "1" "1" "1035" "114.5" "5.39" "2.24" "1" "signal transduction" "cytosol;other cell component" "" "Pf02213" "" "ENSG00000146830" "GIGYF1" "O75420; Q6Y7W7; Q8WZ38" "" "" "0" "0" "1.086" "0.925" "1.363" "1.164" "0.917" "1.439" "1.513" "1.181" "1.648" "29.3" "31.8" "27.1" "39.9" "34.1" "26.9" "42.2" "44.3" "34.6" "48.3" "" "" "" "" "" "" "" "" "" "" "15.5" "17.6" "15.5" "18.4" "18.5" "14.9" "24.8" "24.2" "19.4" "48.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1710541814749781042" "False" "High" "IsMasterProtein" "P54619" "5'-AMP-activated protein kinase subunit gamma-1 OS=Homo sapiens OX=9606 GN=PRKAG1 PE=1 SV=1" "0.001" "False" "3.288" "2" "1" "1" "1" "331" "37.6" "6.92" "2.75" "1" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00571" "5571" "ENSG00000181929" "PRKAG1" "B4DDT7; hsa:5571; P54619; Q8N7V9" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Angiopoietin-like protein 8 regulatory pathway; Leptin and adiponectin; Lipid metabolism pathway; Hereditary leiomyomatosis and renal cell carcinoma pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Pleural mesothelioma" "TP53 Regulates Metabolic Genes; Regulation of TP53 Activity through Phosphorylation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy" "24" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4791788072284182717" "False" "High" "IsMasterProtein" "Q96GM5" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 OS=Homo sapiens OX=9606 GN=SMARCD1 PE=1 SV=2" "0.001" "False" "3.284" "3" "2" "2" "2" "515" "58.2" "9.25" "2.07" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02201" "6602" "ENSG00000066117" "SMARCD1" "A6NN27; hsa:6602; Q92924; Q96GM5; Q9Y635" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6054246856873050357" "False" "High" "IsMasterProtein" "Q15118" "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial OS=Homo sapiens OX=9606 GN=PDK1 PE=1 SV=1" "0.001" "False" "3.283" "5" "2" "2" "2" "436" "49.2" "8.81" "3.67" "2" "cell cycle OR cell proliferation;other metabolic processes;stress response;signal transduction;other biological processes" "mitochondrion" "kinase activity;other molecular function" "Pf02518, Pf10436" "5163" "ENSG00000152256" "PDK1" "B2R6T1; B7Z937; D3DPD8; E9PD65; hsa:5163; Q15118; Q308M4" "T cell receptor and co-stimulatory signaling; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Hereditary leiomyomatosis and renal cell carcinoma pathway; Non-small cell lung cancer; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Aspirin and miRNAs; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; TCA cycle in senescence; Pleural mesothelioma; Orexin receptor pathway; Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution; Glucose metabolism in triple-negative breast cancer cells; GNAQ pathways in port-wine stain; EPO receptor signaling; DNA damage response (only ATM dependent)" "Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Mitochondrial protein degradation" "23" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5177131133338512997" "False" "High" "IsMasterProtein" "Q8IXM3" "Large ribosomal subunit protein mL41 OS=Homo sapiens OX=9606 GN=MRPL41 PE=1 SV=1" "0.001" "False" "3.275" "7" "1" "1" "1" "137" "15.4" "9.57" "2.29" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;other cell component" "other molecular function" "Pf09809" "64975" "ENSG00000182154" "MRPL41" "hsa:64975; Q8IXM3; Q96Q49" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "1" "" "4936048942270731480" "False" "High" "IsMasterProtein" "O00567" "Nucleolar protein 56 OS=Homo sapiens OX=9606 GN=NOP56 PE=1 SV=4" "0.001" "False" "3.274" "3" "1" "1" "1" "594" "66.0" "9.19" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01798, Pf08156" "10528" "ENSG00000101361" "NOP56" "hsa:10528; O00567; Q2M3T6; Q9NQ05" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Association of TriC/CCT with target proteins during biosynthesis" "3" "0" "0.702" "1.172" "1.499" "1.271" "1.151" "1.162" "1.292" "1.301" "0.649" "17.3" "12.1" "20.2" "25.9" "21.9" "19.9" "20.1" "22.3" "22.4" "11.2" "" "" "" "" "" "" "" "" "" "" "9.1" "6.7" "11.6" "11.9" "11.9" "11.1" "11.8" "12.2" "12.6" "11.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-792882720935006206" "False" "High" "IsMasterProtein" "Q9HAV4" "Exportin-5 OS=Homo sapiens OX=9606 GN=XPO5 PE=1 SV=1" "0.001" "False" "3.270" "1" "2" "2" "2" "1204" "136.2" "5.80" "4.15" "2" "RNA metabolism OR transcription;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03810, Pf08389, Pf19273" "57510" "ENSG00000124571" "XPO5" "hsa:57510; Q5JTE6; Q96G48; Q96HN3; Q9BWM6; Q9BZV5; Q9H9M4; Q9HAV4; Q9NT89; Q9NW39; Q9ULC9" "miRNA biogenesis; exRNA mechanism of action and biogenesis; Primary ovarian insufficiency" "MicroRNA (miRNA) biogenesis" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7586099756274293155" "False" "High" "IsMasterProtein" "Q71UM5" "Ribosomal protein eS27-like OS=Homo sapiens OX=9606 GN=RPS27L PE=1 SV=3" "0.001" "False" "3.265" "13" "1" "1" "1" "84" "9.5" "9.45" "2.38" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01667" "51065" "ENSG00000185088" "RPS27L" "hsa:51065; Q71UM5; Q9BTJ1" "" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "18" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1240749293216846131" "False" "High" "IsMasterProtein" "Q13526" "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 OS=Homo sapiens OX=9606 GN=PIN1 PE=1 SV=1" "0.001" "False" "3.261" "5" "1" "1" "1" "163" "18.2" "8.82" "3.01" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00397, Pf00639" "5300" "ENSG00000127445" "PIN1" "A8K4V9; hsa:5300; Q13526; Q53X75" "Novel intracellular components of RIG-I-like receptor pathway" "Regulation of TP53 Activity through Phosphorylation; ISG15 antiviral mechanism; Negative regulators of DDX58/IFIH1 signaling; PI5P Regulates TP53 Acetylation; RHO GTPases Activate NADPH Oxidases" "6" "0" "0.985" "1.005" "0.995" "0.910" "0.885" "0.993" "0.901" "0.900" "1.497" "266.1" "262.0" "267.4" "264.7" "242.3" "235.4" "264.2" "239.7" "239.6" "398.4" "" "" "" "" "" "" "" "" "" "" "140.9" "145.3" "153.2" "121.9" "131.1" "131.0" "155.5" "130.9" "134.4" "398.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6062683060595135562" "False" "High" "IsMasterProtein" "Q9NVE7" "4'-phosphopantetheine phosphatase OS=Homo sapiens OX=9606 GN=PANK4 PE=1 SV=1" "0.001" "False" "3.253" "1" "1" "1" "1" "773" "85.9" "6.28" "2.15" "1" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01937, Pf03630" "55229" "ENSG00000157881; ENSG00000273494" "PANK4" "B9DI84; hsa:55229; Q53EU3; Q5TA84; Q7RTX3; Q9H3X5; Q9NVE7" "1p36 copy number variation syndrome" "Vitamin B5 (pantothenate) metabolism" "2" "0" "1.197" "1.292" "1.427" "1.292" "1.406" "1.199" "1.158" "0.896" "1.603" "50.8" "60.8" "65.6" "72.5" "65.6" "71.4" "60.9" "58.8" "45.5" "81.4" "" "" "" "" "" "" "" "" "" "" "26.9" "33.7" "37.6" "33.4" "35.5" "39.7" "35.8" "32.1" "25.5" "81.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7828527280741994957" "False" "High" "IsMasterProtein" "O75971" "snRNA-activating protein complex subunit 5 OS=Homo sapiens OX=9606 GN=SNAPC5 PE=1 SV=1" "0.001" "False" "3.251" "9" "1" "4" "1" "98" "11.3" "4.58" "9.21" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf15497" "10302" "ENSG00000174446" "SNAPC5" "A8K7N6; hsa:10302; O75971; Q96CF3" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA polymerase II transcribes snRNA genes" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8429981221702182893" "False" "High" "IsMasterProtein" "P20340" "Ras-related protein Rab-6A OS=Homo sapiens OX=9606 GN=RAB6A PE=1 SV=3" "0.001" "False" "3.250" "7" "1" "2" "1" "208" "23.6" "5.54" "5.31" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "5870" "ENSG00000175582" "RAB6A" "A8K133; B7Z772; F5H668; hsa:5870; P20340; Q1W5D8; Q5U0A8; Q9UBE4" "" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; COPI-independent Golgi-to-ER retrograde traffic; Pre-NOTCH Processing in Golgi; Retrograde transport at the Trans-Golgi-Network; TBC/RABGAPs" "7" "0" "1.094" "1.114" "1.183" "1.248" "1.284" "1.325" "1.247" "1.318" "0.781" "80.7" "88.2" "89.9" "95.4" "100.7" "103.6" "106.9" "100.6" "106.4" "63.0" "" "" "" "" "" "" "" "" "" "" "42.7" "48.9" "51.5" "44.0" "54.5" "57.6" "62.9" "54.9" "59.7" "63.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2744059212078180576" "False" "High" "IsMasterProtein" "P17029" "Zinc finger protein with KRAB and SCAN domains 1 OS=Homo sapiens OX=9606 GN=ZKSCAN1 PE=1 SV=3" "0.001" "False" "3.245" "2" "1" "1" "1" "563" "63.6" "7.05" "2.54" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352, Pf02023" "7586" "ENSG00000106261" "ZKSCAN1" "A4D294; hsa:7586; P17029; P52745; Q2M1U1; Q8TBW5; Q8TEK7" "" "Generic Transcription Pathway" "1" "0" "1.170" "1.120" "1.144" "1.019" "1.088" "0.852" "0.351" "0.918" "5.913" "35.9" "42.0" "40.2" "41.1" "36.6" "39.1" "30.6" "12.6" "33.0" "212.4" "" "" "" "" "" "" "" "" "" "" "19.0" "23.3" "23.0" "18.9" "19.8" "21.7" "18.0" "6.9" "18.5" "212.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1015618648752571383" "False" "High" "IsMasterProtein" "P55210" "Caspase-7 OS=Homo sapiens OX=9606 GN=CASP7 PE=1 SV=1" "0.001" "False" "3.244" "7" "2" "2" "2" "303" "34.3" "6.07" "1.97" "2" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00656" "840" "ENSG00000165806" "CASP7" "B4DQU7; B5BU45; D3DRB8; hsa:840; P55210; Q13364; Q53YD5; Q5SVL0; Q5SVL3; Q96BA0" "Nucleotide-binding oligomerization domain (NOD) pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Allograft rejection; Parkinson's disease pathway; Oncostatin M signaling pathway; Nanomaterial induced apoptosis; Apoptosis; Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; RAC1/PAK1/p38/MMP2 pathway; Hepatitis C and hepatocellular carcinoma; Apoptosis modulation by HSP70; ERK pathway in Huntington's disease; Acute viral myocarditis; Nonalcoholic fatty liver disease; Host-pathogen interaction of human coronaviruses - apoptosis; 3q29 copy number variation syndrome; Complement system in neuronal development and plasticity; Alzheimer's disease" "Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Caspase-mediated cleavage of cytoskeletal proteins" "27" "0" "1.020" "0.598" "1.580" "1.041" "0.587" "1.388" "0.667" "0.503" "0.535" "633.0" "645.5" "378.7" "1000.2" "658.8" "371.7" "878.5" "421.9" "318.4" "338.6" "" "" "" "" "" "" "" "" "" "" "335.2" "357.9" "216.9" "460.6" "356.4" "206.7" "517.0" "230.3" "178.6" "338.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3366730786778732406" "False" "High" "IsMasterProtein" "Q9UKB3" "DnaJ homolog subfamily C member 12 OS=Homo sapiens OX=9606 GN=DNAJC12 PE=1 SV=1" "0.001" "False" "3.238" "5" "1" "1" "1" "198" "23.4" "5.71" "2.66" "1" "" "other cell component" "" "Pf00226" "56521" "ENSG00000108176" "DNAJC12" "hsa:56521; Q5JVQ1; Q9UKB2; Q9UKB3" "" "" "0" "0" "1.039" "0.976" "1.064" "1.110" "0.958" "1.056" "1.151" "0.926" "0.726" "92.5" "96.1" "90.3" "98.4" "102.7" "88.6" "97.7" "106.5" "85.7" "67.2" "" "" "" "" "" "" "" "" "" "" "49.0" "53.3" "51.7" "45.3" "55.6" "49.3" "57.5" "58.2" "48.1" "67.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1400550207963658767" "False" "High" "IsMasterProtein" "Q8WWY3" "U4/U6 small nuclear ribonucleoprotein Prp31 OS=Homo sapiens OX=9606 GN=PRPF31 PE=1 SV=2" "0.001" "False" "3.226" "2" "1" "1" "1" "499" "55.4" "5.78" "2.94" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01798, Pf09785" "26121" "ENSG00000105618; ENSG00000274144; ENSG00000274651; ENSG00000274894; ENSG00000275117; ENSG00000275885; ENSG00000276421; ENSG00000277154; ENSG00000277707; ENSG00000277953" "PRPF31" "E7ESA8; F1T0A4; F1T0A5; hsa:26121; Q17RB4; Q8N7F9; Q8WWY3; Q9H271; Q9Y439" "" "mRNA Splicing - Major Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4463882674882175167" "False" "High" "IsMasterProtein" "Q5NDL2" "EGF domain-specific O-linked N-acetylglucosamine transferase OS=Homo sapiens OX=9606 GN=EOGT PE=1 SV=1" "0.001" "False" "3.223" "3" "2" "2" "2" "527" "62.0" "7.05" "4.20" "2" "protein metabolism;other metabolic processes" "ER/Golgi" "other molecular function" "Pf04577" "285203" "ENSG00000163378" "EOGT" "A8K2U1; B4DFH5; hsa:285203; L7X1M5; Q5NDL2; Q6MZY0; Q6P985; Q6ZTV0" "Genetic causes of porto-sinusoidal vascular disease" "" "1" "0" "1.026" "0.865" "1.026" "1.181" "1.254" "1.030" "0.925" "1.234" "1.565" "122.0" "125.2" "105.5" "125.1" "144.0" "152.9" "125.6" "112.8" "150.5" "190.9" "" "" "" "" "" "" "" "" "" "" "64.6" "69.4" "60.4" "57.6" "77.9" "85.1" "73.9" "61.6" "84.4" "190.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1178215793923997367" "False" "High" "IsMasterProtein" "Q96DM3" "Regulator of MON1-CCZ1 complex OS=Homo sapiens OX=9606 GN=RMC1 PE=1 SV=2" "0.001" "False" "3.214" "2" "1" "1" "1" "657" "74.9" "7.83" "2.38" "1" "other metabolic processes;other biological processes" "other membranes;other cytoplasmic organelle" "" "Pf07035, Pf21029" "29919" "ENSG00000141452" "RMC1" "Q96DM3; Q9BU17; Q9Y5M0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2776993726351284183" "False" "High" "IsMasterProtein" "Q9BVJ6" "U3 small nucleolar RNA-associated protein 14 homolog A OS=Homo sapiens OX=9606 GN=UTP14A PE=1 SV=1" "0.001" "False" "3.212" "3" "2" "2" "2" "771" "87.9" "7.87" "2.10" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf04615" "10813" "ENSG00000156697" "UTP14A" "A8K7A3; A8MVQ1; B4DQ08; E9PEL7; hsa:10813; Q5JYF1; Q9BVJ6" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4461868117343589472" "False" "High" "IsMasterProtein" "Q66K14" "TBC1 domain family member 9B OS=Homo sapiens OX=9606 GN=TBC1D9B PE=1 SV=3" "0.001" "False" "3.211" "1" "1" "1" "1" "1250" "140.4" "5.25" "2.22" "1" "" "other membranes" "enzyme regulator activity;other molecular function" "Pf00566, Pf02893" "23061" "ENSG00000197226; ENSG00000284400" "TBC1D9B" "D3DWQ5; D3DWQ6; hsa:23061; O75163; Q53EY0; Q66K14; Q6MZI2; Q96H49" "" "" "0" "0" "0.922" "0.747" "1.018" "0.801" "0.771" "0.910" "0.734" "0.704" "2.669" "40.2" "37.0" "30.0" "40.9" "32.2" "31.0" "36.6" "29.5" "28.3" "107.2" "" "" "" "" "" "" "" "" "" "" "21.3" "20.5" "17.2" "18.8" "17.4" "17.2" "21.5" "16.1" "15.9" "107.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1224423870794083930" "False" "High" "IsMasterProtein" "P49356" "Protein farnesyltransferase subunit beta OS=Homo sapiens OX=9606 GN=FNTB PE=1 SV=1" "0.001" "False" "3.210" "2" "1" "1" "1" "437" "48.7" "5.82" "2.59" "1" "protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00432" "100529261; 2342" "ENSG00000257365" "FNTB" "B2RDX6; B4E1A0; hsa:100529261; hsa:2342; P49356" "" "Potential therapeutics for SARS; Inactivation, recovery and regulation of the phototransduction cascade; RAS processing" "3" "0" "0.926" "0.864" "0.976" "1.079" "1.011" "1.075" "0.936" "0.904" "0.838" "144.0" "133.4" "124.4" "140.6" "155.4" "145.5" "154.9" "134.8" "130.1" "120.7" "" "" "" "" "" "" "" "" "" "" "76.3" "74.0" "71.3" "64.8" "84.1" "81.0" "91.1" "73.6" "73.0" "120.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1234088544826657040" "False" "High" "IsMasterProtein" "Q9H871" "E3 ubiquitin-protein transferase RMND5A OS=Homo sapiens OX=9606 GN=RMND5A PE=1 SV=1" "0.001" "False" "3.208" "2" "1" "1" "1" "391" "44.0" "6.06" "2.68" "1" "protein metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf10607, Pf13445" "64795" "ENSG00000153561" "RMND5A" "D6W5M6; hsa:64795; Q6NTF0; Q9H6W5; Q9H871; Q9H9H2" "Ciliary landscape" "" "1" "0" "1.185" "1.012" "1.242" "1.332" "1.084" "1.235" "0.985" "1.083" "1.989" "117.0" "138.6" "118.4" "145.3" "155.9" "126.8" "144.5" "115.2" "126.7" "232.7" "" "" "" "" "" "" "" "" "" "" "61.9" "76.9" "67.8" "66.9" "84.3" "70.5" "85.0" "62.9" "71.1" "232.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2179808201318642480" "False" "High" "IsMasterProtein" "Cont_Q3SZR3" "Alpha-1-acid glycoprotein OS=Bos taurus OX=9913 GN=ORM1 PE=2 SV=1" "0.001" "True" "3.203" "4" "1" "1" "1" "202" "23.2" "5.87" "3.05" "1" "stress response;other biological processes" "non-structural extracellular" "" "Pf00061" "497200" "" "ORM1" "bta:497200; Q3SZR3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7900354501110065761" "False" "High" "IsMasterProtein" "O00170" "AH receptor-interacting protein OS=Homo sapiens OX=9606 GN=AIP PE=1 SV=3" "0.001" "False" "3.201" "2" "1" "1" "1" "330" "37.6" "6.42" "3.57" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00254" "9049" "ENSG00000110711" "AIP" "A0SZW3; A0SZW4; A0SZW5; A0SZW6; G9I2H4; hsa:9049; O00170; Q2M3Q2; Q99606" "Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway" "Aryl hydrocarbon receptor signalling; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "5" "0" "1.047" "0.890" "0.944" "1.059" "0.920" "0.931" "0.845" "1.083" "3.761" "142.6" "149.3" "126.9" "134.5" "151.0" "131.2" "132.8" "120.4" "154.4" "536.2" "" "" "" "" "" "" "" "" "" "" "75.5" "82.8" "72.7" "62.0" "81.7" "73.0" "78.1" "65.7" "86.6" "536.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1398033593130895886" "False" "High" "IsMasterProtein" "O43264" "Centromere/kinetochore protein zw10 homolog OS=Homo sapiens OX=9606 GN=ZW10 PE=1 SV=3" "0.001" "False" "3.199" "1" "1" "2" "1" "779" "88.8" "6.27" "4.47" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf06248, Pf20665, Pf20666" "9183" "ENSG00000086827" "ZW10" "A1A528; hsa:9183; O43264" "" "COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "0.885" "0.999" "0.927" "1.086" "0.997" "1.278" "1.016" "1.217" "3.801" "121.6" "107.7" "121.5" "112.8" "132.1" "121.2" "155.4" "123.6" "148.0" "462.3" "" "" "" "" "" "" "" "" "" "" "64.4" "59.7" "69.6" "51.9" "71.5" "67.4" "91.4" "67.5" "83.0" "462.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9193624318579361527" "False" "High" "IsMasterProtein" "Q9UGI8" "Testin OS=Homo sapiens OX=9606 GN=TES PE=1 SV=1" "0.001" "False" "3.187" "2" "1" "1" "1" "421" "48.0" "7.68" "2.84" "1" "other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00412, Pf06297" "26136" "ENSG00000135269" "TES" "A4D0U6; hsa:26136; Q9GZQ1; Q9HAJ9; Q9UGI8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7534759113121094513" "False" "High" "IsMasterProtein" "Q9Y3D9" "Small ribosomal subunit protein mS23 OS=Homo sapiens OX=9606 GN=MRPS23 PE=1 SV=2" "0.001" "False" "3.185" "9" "2" "3" "2" "190" "21.8" "8.90" "2.26" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf10484" "51649" "ENSG00000181610" "MRPS23" "B2R6V3; hsa:51649; Q96Q24; Q9BWH8; Q9P053; Q9Y3D9" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5131911605729766219" "False" "High" "IsMasterProtein" "O60516" "Eukaryotic translation initiation factor 4E-binding protein 3 OS=Homo sapiens OX=9606 GN=EIF4EBP3 PE=1 SV=1" "0.001" "False" "3.184" "18" "1" "1" "1" "100" "10.9" "4.48" "0.00" "1" "other biological processes" "translational apparatus;nucleus;other cell component" "other molecular function" "Pf05456" "8637" "ENSG00000243056" "EIF4EBP3" "hsa:8637; O60516" "Translation factors" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5623462440984321357" "False" "High" "IsMasterProtein" "Q96CW5" "Gamma-tubulin complex component 3 OS=Homo sapiens OX=9606 GN=TUBGCP3 PE=1 SV=2" "0.001" "False" "3.174" "1" "1" "1" "1" "907" "103.5" "8.12" "2.10" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf04130, Pf17681" "10426" "ENSG00000126216" "TUBGCP3" "hsa:10426; O43631; O60852; O60853; Q5T8L2; Q7Z4K1; Q96CW5; Q96I79" "Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1871023154594230453" "False" "High" "IsMasterProtein" "Q14241" "Elongin-A OS=Homo sapiens OX=9606 GN=ELOA PE=1 SV=3" "0.001" "False" "3.170" "1" "1" "3" "1" "772" "87.2" "9.57" "6.63" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf06881, Pf08711" "6924" "ENSG00000011007" "ELOA" "B2R7Q8; hsa:6924; Q14241; Q8IXH1" "VEGFA-VEGFR2 signaling; MET in type 1 papillary renal cell carcinoma; 10q11.21q11.23 copy number variation syndrome" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8359859415185382416" "False" "High" "IsMasterProtein" "O75575" "DNA-directed RNA polymerase III subunit RPC9 OS=Homo sapiens OX=9606 GN=CRCP PE=1 SV=1" "0.001" "False" "3.167" "5" "1" "1" "1" "148" "16.9" "5.39" "2.75" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03874" "27297" "ENSG00000241258" "CRCP" "A8MUZ4; A8MW23; B2R4H4; B4E198; hsa:27297; O75575; Q3KRA3; Q5HYF1; Q8IXL4" "Myometrial relaxation and contraction pathways" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "8" "0" "1.016" "1.005" "1.104" "1.241" "1.143" "0.932" "1.044" "1.051" "0.924" "49.4" "50.2" "49.6" "54.5" "61.3" "56.4" "46.0" "51.5" "51.9" "45.6" "" "" "" "" "" "" "" "" "" "" "26.1" "27.8" "28.4" "25.1" "33.2" "31.4" "27.1" "28.1" "29.1" "45.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3684476333316036577" "False" "High" "IsMasterProtein" "Q5R372" "Rab GTPase-activating protein 1-like OS=Homo sapiens OX=9606 GN=RABGAP1L PE=1 SV=1" "0.001" "False" "3.159" "1" "1" "1" "1" "815" "92.5" "5.31" "3.19" "1" "transport;other biological processes" "ER/Golgi;nucleus;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00566, Pf00640, Pf12473" "9910" "ENSG00000152061" "RABGAP1L" "O75059; Q3ZTR8; Q5R369; Q5R372; Q8IVV0; Q8N921; Q8WV78; Q9NSP8; Q9UQ19; Q9UQP5; Q9Y6Y5; Q9Y6Y6" "" "" "0" "0" "1.062" "1.032" "0.998" "1.023" "1.041" "0.998" "0.940" "1.073" "1.199" "174.0" "184.8" "179.5" "173.7" "178.0" "181.2" "173.6" "163.6" "186.7" "208.7" "" "" "" "" "" "" "" "" "" "" "92.1" "102.4" "102.8" "80.0" "96.3" "100.8" "102.2" "89.3" "104.8" "208.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4125655909395712746" "False" "High" "IsMasterProtein" "Q8IUR7" "Armadillo repeat-containing protein 8 OS=Homo sapiens OX=9606 GN=ARMC8 PE=1 SV=2" "0.001" "False" "3.158" "2" "1" "1" "1" "673" "75.5" "6.73" "2.96" "1" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00514" "25852" "ENSG00000114098" "ARMC8" "A8K0L2; B7Z441; B7Z453; D3DNE6; F5GWK4; hsa:25852; Q6PIL2; Q8IUR7; Q96D19; Q96HZ5; Q9NV02; Q9NV94; Q9Y4R9" "Ciliary landscape" "Neutrophil degranulation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5919366994915360532" "False" "High" "IsMasterProtein" "Q8NI60" "Atypical kinase COQ8A, mitochondrial OS=Homo sapiens OX=9606 GN=COQ8A PE=1 SV=1" "0.001" "False" "3.154" "3" "2" "3" "2" "647" "71.9" "6.99" "3.76" "2" "other metabolic processes" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf03109" "56997" "ENSG00000163050" "COQ8A" "hsa:56997; Q5T7A5; Q63HK0; Q8NCJ6; Q8NI60; Q9HBQ1; Q9NQ67" "" "" "0" "0" "1.008" "0.897" "0.923" "0.938" "0.929" "0.712" "0.570" "0.672" "1.323" "223.0" "224.9" "200.1" "205.9" "209.2" "207.2" "158.8" "127.2" "149.9" "295.0" "" "" "" "" "" "" "" "" "" "" "118.1" "124.7" "114.6" "94.8" "113.2" "115.3" "93.5" "69.4" "84.1" "295.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8772663144839085983" "False" "High" "IsMasterProtein" "O14965" "Aurora kinase A OS=Homo sapiens OX=9606 GN=AURKA PE=1 SV=3" "0.001" "False" "3.148" "2" "1" "2" "1" "403" "45.8" "9.39" "2.90" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6790" "ENSG00000087586" "AURKA" "E1P5F9; hsa:6790; O14965; O60445; O75873; Q9BQD6; Q9UPG5" "Gastric cancer network 1; EGF/EGFR signaling pathway; p53 transcriptional gene network; HDAC6 interactions in the central nervous system" "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; SUMOylation of DNA replication proteins; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Interaction between PHLDA1 and AURKA" "12" "0" "1.022" "1.183" "1.046" "1.007" "0.759" "0.876" "0.924" "0.724" "0.711" "73.9" "75.5" "87.4" "77.2" "74.4" "56.0" "64.7" "68.2" "53.5" "52.5" "" "" "" "" "" "" "" "" "" "" "39.1" "41.8" "50.0" "35.6" "40.3" "31.2" "38.1" "37.2" "30.0" "52.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7703205907594076097" "False" "High" "IsMasterProtein" "Q12982" "BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 OS=Homo sapiens OX=9606 GN=BNIP2 PE=1 SV=1" "0.001" "False" "3.140" "4" "1" "2" "1" "314" "36.0" "4.81" "5.85" "1" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf12496, Pf13716" "663" "ENSG00000140299" "BNIP2" "B4DS94; hsa:663; Q12982" "Acute viral myocarditis" "Myogenesis" "2" "0" "1.111" "1.016" "1.012" "1.108" "1.033" "1.122" "1.036" "1.079" "1.148" "81.1" "90.1" "82.4" "82.0" "89.8" "83.7" "91.0" "84.0" "87.5" "93.0" "" "" "" "" "" "" "" "" "" "" "42.9" "49.9" "47.2" "37.8" "48.6" "46.6" "53.6" "45.9" "49.1" "93.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8713380436033100522" "False" "High" "IsMasterProtein" "Q71SY5" "Mediator of RNA polymerase II transcription subunit 25 OS=Homo sapiens OX=9606 GN=MED25 PE=1 SV=2" "0.001" "False" "3.139" "1" "1" "1" "1" "747" "78.1" "8.34" "2.06" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11232, Pf11235, Pf11265" "81857" "ENSG00000104973" "MED25" "A8K095; B9TX30; hsa:81857; O95783; Q6P143; Q6QMH5; Q707U4; Q71SY5; Q8TB55; Q9H0L5; Q9HB34" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "0.826" "0.587" "0.802" "1.031" "0.960" "0.886" "0.700" "0.794" "1.060" "27.6" "22.8" "16.2" "22.2" "28.5" "26.5" "24.5" "19.3" "22.0" "29.3" "" "" "" "" "" "" "" "" "" "" "14.6" "12.7" "9.3" "10.2" "15.4" "14.8" "14.4" "10.6" "12.3" "29.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-996241339141020167" "False" "High" "IsMasterProtein" "Q96SB8" "Structural maintenance of chromosomes protein 6 OS=Homo sapiens OX=9606 GN=SMC6 PE=1 SV=2" "0.001" "False" "3.135" "1" "1" "1" "1" "1091" "126.2" "6.99" "2.37" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13476" "79677" "ENSG00000163029" "SMC6" "A8K8Q6; D6W518; hsa:79677; Q05BV4; Q96SB8; Q9H0X3; Q9H6M0" "" "SUMOylation of DNA damage response and repair proteins" "1" "0" "1.330" "1.088" "1.294" "1.316" "1.443" "1.237" "1.109" "1.345" "2.440" "76.9" "102.3" "83.6" "99.4" "101.1" "110.9" "95.1" "85.3" "103.4" "187.5" "" "" "" "" "" "" "" "" "" "" "40.7" "56.7" "47.9" "45.8" "54.7" "61.7" "55.9" "46.5" "58.0" "187.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1604052202135203910" "False" "High" "IsMasterProtein" "O00592" "Podocalyxin OS=Homo sapiens OX=9606 GN=PODXL PE=1 SV=2" "0.001" "False" "3.131" "2" "1" "2" "1" "558" "58.6" "5.49" "4.99" "1" "cell adhesion;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "" "Pf06365" "5420" "ENSG00000128567" "PODXL" "A6NHX8; hsa:5420; O00592; Q52LZ7; Q53ER6" "Primary focal segmental glomerulosclerosis (FSGS); Ectoderm differentiation; Hepatitis C and hepatocellular carcinoma; Nephrotic syndrome; Pleural mesothelioma" "" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3281625266906913156" "False" "High" "IsMasterProtein" "Q7RTP6" "[F-actin]-monooxygenase MICAL3 OS=Homo sapiens OX=9606 GN=MICAL3 PE=1 SV=2" "0.001" "False" "3.131" "0" "1" "1" "1" "2002" "224.2" "5.55" "2.50" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00412, Pf01494, Pf12130" "57553" "ENSG00000243156" "MICAL3" "B2RXJ5; E9PEF0; O94909; Q5U4P4; Q6ICK4; Q7RTP6; Q96DF2; Q9P2I3" "" "" "0" "0" "0.964" "0.965" "1.146" "0.997" "0.929" "0.939" "0.840" "0.991" "1.579" "45.2" "43.5" "43.6" "51.7" "45.0" "41.9" "42.4" "37.9" "44.8" "71.3" "" "" "" "" "" "" "" "" "" "" "23.9" "24.1" "24.9" "23.8" "24.4" "23.3" "24.9" "20.7" "25.1" "71.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3559430331434459476" "False" "High" "IsMasterProtein" "O95630" "STAM-binding protein OS=Homo sapiens OX=9606 GN=STAMBP PE=1 SV=1" "0.001" "False" "3.125" "2" "1" "1" "1" "424" "48.0" "6.29" "2.85" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf01398, Pf08969" "10617" "ENSG00000124356" "STAMBP" "B5M0B6; D6W5H7; hsa:10617; O95630; Q3MJE7" "EGF/EGFR signaling pathway" "Metalloprotease DUBs" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3285411290895157654" "False" "High" "IsMasterProtein" "Q9H6H4" "Receptor expression-enhancing protein 4 OS=Homo sapiens OX=9606 GN=REEP4 PE=1 SV=1" "0.001" "False" "3.124" "3" "1" "1" "1" "257" "29.4" "9.73" "2.45" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;cytoskeleton;ER/Golgi" "cytoskeletal activity" "Pf03134" "80346" "ENSG00000168476" "REEP4" "D3DSQ9; hsa:80346; Q86VL1; Q9H6H4; Q9H6I5; Q9HBP4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6052535811300559173" "False" "High" "IsMasterProtein" "Q2NL82" "Pre-rRNA-processing protein TSR1 homolog OS=Homo sapiens OX=9606 GN=TSR1 PE=1 SV=1" "0.001" "False" "3.124" "1" "1" "1" "1" "804" "91.8" "7.42" "2.84" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04950, Pf08142" "55720" "ENSG00000167721" "TSR1" "hsa:55720; Q2NL82; Q8WUY5; Q9NVT0; Q9P2E6" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2000966759959030184" "False" "High" "IsMasterProtein" "Q9H267" "Vacuolar protein sorting-associated protein 33B OS=Homo sapiens OX=9606 GN=VPS33B PE=1 SV=2" "0.001" "False" "3.122" "3" "2" "2" "2" "617" "70.5" "6.71" "1.87" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00995" "26276" "ENSG00000184056" "VPS33B" "B3KQF6; hsa:26276; Q96K14; Q9H267; Q9NRP6; Q9NSF3" "" "Prevention of phagosomal-lysosomal fusion; SARS-CoV-2 modulates autophagy" "2" "0" "1.122" "0.988" "1.401" "1.335" "1.083" "1.058" "0.929" "1.238" "2.709" "50.8" "57.0" "50.1" "71.1" "67.8" "55.0" "53.7" "47.1" "62.9" "137.5" "" "" "" "" "" "" "" "" "" "" "26.9" "31.6" "28.7" "32.8" "36.7" "30.6" "31.6" "25.7" "35.3" "137.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "576551174696518957" "False" "High" "IsMasterProtein" "Q5T447" "E3 ubiquitin-protein ligase HECTD3 OS=Homo sapiens OX=9606 GN=HECTD3 PE=1 SV=1" "0.001" "False" "3.114" "1" "1" "1" "1" "861" "97.1" "5.64" "2.15" "1" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00632, Pf03256" "79654" "ENSG00000126107" "HECTD3" "B3KPV7; B3KRH4; hsa:79654; Q5T447; Q5T448; Q9H783" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5294747431044223143" "False" "High" "IsMasterProtein" "Q9UBN7" "Histone deacetylase 6 OS=Homo sapiens OX=9606 GN=HDAC6 PE=1 SV=2" "0.001" "False" "3.104" "1" "2" "2" "2" "1215" "131.3" "5.30" "2.69" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00850, Pf02148" "10013" "ENSG00000094631" "HDAC6" "hsa:10013; O94975; Q6NT75; Q7L3E5; Q96CY0; Q9UBN7" "Neural crest differentiation; Ectoderm differentiation; Ectoderm differentiation; Ethanol effects on histone modifications; 7q11.23 copy number variation syndrome; HDAC6 interactions in the central nervous system" "Late endosomal microautophagy; Chaperone Mediated Autophagy; Cilium Assembly; Aggrephagy; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Transcriptional regulation by RUNX2; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX2 regulates osteoblast differentiation; HSF1 activation" "17" "0" "0.747" "0.918" "0.703" "0.637" "0.741" "0.787" "0.721" "0.662" "0.662" "125.1" "93.5" "114.8" "87.9" "79.7" "92.7" "98.4" "90.2" "82.8" "82.8" "" "" "" "" "" "" "" "" "" "" "66.2" "51.8" "65.8" "40.5" "43.1" "51.6" "57.9" "49.2" "46.5" "82.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4655855300014543961" "False" "High" "IsMasterProtein" "Q06330" "Recombining binding protein suppressor of hairless OS=Homo sapiens OX=9606 GN=RBPJ PE=1 SV=3" "0.001" "False" "3.102" "2" "1" "1" "1" "500" "55.6" "7.18" "2.72" "1" "cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09270, Pf09271, Pf20144" "3516" "ENSG00000168214" "RBPJ" "B4DY22; hsa:3516; Q06330; Q5XKH9; Q6P1N3" "Neural crest differentiation; Notch signaling; Canonical and non-canonical Notch signaling; PTF1A related regulatory pathway; Epithelial to mesenchymal transition in colorectal cancer; Osteoblast differentiation and related diseases; Genetic causes of porto-sinusoidal vascular disease; Notch signaling pathway" "Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Formation of paraxial mesoderm; Somitogenesis; Pre-NOTCH Transcription and Translation; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH2 intracellular domain regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "20" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8950408743700017704" "False" "High" "IsMasterProtein" "O60645" "Exocyst complex component 3 OS=Homo sapiens OX=9606 GN=EXOC3 PE=1 SV=3" "0.001" "False" "3.100" "1" "1" "1" "1" "745" "85.5" "6.29" "2.67" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf06046" "11336" "ENSG00000180104" "EXOC3" "hsa:11336; O60645; Q6P2E8; Q8TEN6; Q8WUW0; Q96DI4" "Ciliary landscape" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "4" "0" "0.941" "1.005" "1.195" "1.393" "1.062" "1.044" "0.732" "1.192" "4.317" "41.5" "39.1" "41.7" "49.7" "57.9" "44.1" "43.4" "30.4" "49.5" "179.3" "" "" "" "" "" "" "" "" "" "" "22.0" "21.7" "23.9" "22.9" "31.3" "24.5" "25.5" "16.6" "27.8" "179.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3382226448836069029" "False" "High" "IsMasterProtein" "Q69YH5" "Cell division cycle-associated protein 2 OS=Homo sapiens OX=9606 GN=CDCA2 PE=1 SV=2" "0.001" "False" "3.099" "1" "1" "1" "1" "1023" "112.6" "8.40" "2.20" "1" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "" "Pf15276" "157313" "ENSG00000184661" "CDCA2" "hsa:157313; Q3SX74; Q4G0W0; Q5RKN0; Q69YH5; Q69YI4; Q6P464; Q8N7C1" "" "" "0" "0" "0.823" "0.764" "1.195" "0.957" "0.869" "1.105" "0.987" "1.181" "1.002" "53.7" "44.2" "41.0" "64.2" "51.4" "46.7" "59.3" "53.0" "63.4" "53.8" "" "" "" "" "" "" "" "" "" "" "28.4" "24.5" "23.5" "29.6" "27.8" "26.0" "34.9" "28.9" "35.6" "53.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4646306898255403066" "False" "High" "IsMasterProtein" "Q96FF9" "Sororin OS=Homo sapiens OX=9606 GN=CDCA5 PE=1 SV=1" "0.001" "False" "3.099" "3" "1" "2" "1" "252" "27.6" "9.61" "5.75" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf09666" "113130" "ENSG00000146670" "CDCA5" "A8K625; hsa:113130; Q96FF9" "" "Resolution of Sister Chromatid Cohesion; Separation of Sister Chromatids; Establishment of Sister Chromatid Cohesion" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-431742904065760490" "False" "High" "IsMasterProtein" "O75955" "Flotillin-1 OS=Homo sapiens OX=9606 GN=FLOT1 PE=1 SV=3" "0.001" "False" "3.098" "2" "1" "1" "1" "427" "47.3" "7.49" "1.99" "1" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01145" "10211" "ENSG00000137312; ENSG00000206379; ENSG00000206480; ENSG00000230143; ENSG00000232280" "FLOT1" "B4DVY7; hsa:10211; O75955; Q969J8; Q9UHW1; Q9UNV8" "Angiopoietin-like protein 8 regulatory pathway; Insulin signaling" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Regulation of necroptotic cell death; Synaptic adhesion-like molecules" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-81494833362564834" "False" "High" "IsMasterProtein" "Q8WVJ2" "NudC domain-containing protein 2 OS=Homo sapiens OX=9606 GN=NUDCD2 PE=1 SV=1" "0.001" "False" "3.089" "6" "1" "1" "1" "157" "17.7" "5.07" "3.13" "1" "protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf04969" "134492" "ENSG00000170584" "NUDCD2" "B2R4V0; hsa:134492; Q8WVJ2" "" "" "0" "0" "0.931" "0.819" "0.884" "0.990" "0.983" "1.003" "0.642" "0.884" "6.186" "91.6" "85.2" "75.0" "81.0" "90.7" "90.0" "91.8" "58.8" "81.0" "566.5" "" "" "" "" "" "" "" "" "" "" "48.5" "47.3" "43.0" "37.3" "49.1" "50.1" "54.1" "32.1" "45.4" "566.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5456206388273003181" "False" "High" "IsMasterProtein" "O95985" "DNA topoisomerase 3-beta-1 OS=Homo sapiens OX=9606 GN=TOP3B PE=1 SV=1" "0.001" "False" "3.088" "1" "1" "1" "1" "862" "96.6" "8.12" "2.53" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01131, Pf01751" "8940" "ENSG00000100038" "TOP3B" "A0M8Q3; hsa:8940; O95985; Q9BUP5" "" "" "0" "0" "1.012" "1.022" "1.087" "1.016" "1.070" "1.309" "1.377" "1.642" "1.020" "64.4" "65.2" "65.8" "70.0" "65.5" "68.9" "84.3" "88.7" "105.8" "65.7" "" "" "" "" "" "" "" "" "" "" "34.1" "36.2" "37.7" "32.2" "35.4" "38.3" "49.6" "48.4" "59.3" "65.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4297435359722797915" "False" "High" "IsMasterProtein" "Q99755" "Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha OS=Homo sapiens OX=9606 GN=PIP5K1A PE=1 SV=1" "0.001" "False" "3.088" "2" "1" "1" "1" "562" "62.6" "8.21" "2.33" "1" "cell adhesion;cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf01504" "8394" "ENSG00000143398" "PIP5K1A" "A8K4Q0; B4DIN0; hsa:8394; Q99754; Q99755; Q99756" "B cell receptor signaling pathway; Regulation of actin cytoskeleton" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" "4" "0" "1.194" "0.850" "1.335" "1.143" "0.827" "1.091" "0.820" "1.109" "0.569" "18.5" "22.0" "15.7" "24.7" "21.1" "15.3" "20.1" "15.1" "20.5" "10.5" "" "" "" "" "" "" "" "" "" "" "9.8" "12.2" "9.0" "11.4" "11.4" "8.5" "11.9" "8.3" "11.5" "10.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3881079650873622249" "False" "High" "IsMasterProtein" "P29466" "Caspase-1 OS=Homo sapiens OX=9606 GN=CASP1 PE=1 SV=1" "0.001" "False" "3.086" "2" "1" "1" "1" "404" "45.1" "5.91" "3.01" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00619, Pf00656" "834" "ENSG00000137752" "CASP1" "B5MDZ1; hsa:834; P29466; Q53EY6; Q6DMQ1; Q6GSS3; Q6PI75; Q9UCN3" "Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis modulation and signaling; Parkin-ubiquitin proteasomal system pathway; Amyotrophic lateral sclerosis (ALS); Apoptosis; Cytosolic DNA-sensing pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Pleural mesothelioma; Prostaglandin signaling" "TP53 Regulates Transcription of Caspase Activators and Caspases; The AIM2 inflammasome; NOD1/2 Signaling Pathway; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; SARS-CoV-1 activates/modulates innate immune responses; Pyroptosis; Interleukin-37 signaling; Interleukin-1 processing; The IPAF inflammasome" "19" "0" "1.543" "1.361" "1.637" "1.237" "1.447" "1.315" "0.577" "1.415" "9.924" "74.7" "115.2" "101.6" "122.2" "92.4" "108.0" "98.2" "43.1" "105.6" "740.9" "" "" "" "" "" "" "" "" "" "" "39.5" "63.9" "58.2" "56.3" "50.0" "60.1" "57.8" "23.5" "59.2" "740.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "798152879982526566" "False" "High" "IsMasterProtein" "Q8WWH5" "Pseudouridylate synthase TRUB1 OS=Homo sapiens OX=9606 GN=TRUB1 PE=1 SV=1" "0.001" "False" "3.080" "3" "1" "1" "1" "349" "37.2" "8.25" "3.50" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf01509" "142940" "ENSG00000165832" "TRUB1" "B2R716; hsa:142940; Q53ES2; Q8WWH5" "" "" "0" "0" "1.092" "1.068" "1.062" "0.960" "1.021" "0.906" "0.906" "0.980" "1.243" "189.6" "207.1" "202.6" "201.4" "182.0" "193.5" "171.9" "171.9" "185.8" "235.8" "" "" "" "" "" "" "" "" "" "" "100.4" "114.8" "116.0" "92.8" "98.5" "107.7" "101.2" "93.8" "104.2" "235.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6481945204603063978" "False" "High" "IsMasterProtein" "Q9UBB6" "Neurochondrin OS=Homo sapiens OX=9606 GN=NCDN PE=1 SV=1" "0.001" "False" "3.076" "1" "1" "1" "1" "729" "78.8" "5.48" "2.54" "1" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf05536" "23154" "ENSG00000020129" "NCDN" "D3DPR9; hsa:23154; Q9UBB6; Q9UBY2; Q9Y4A6; Q9Y4D9" "Splicing factor NOVA regulated synaptic proteins" "" "1" "0" "1.006" "0.893" "1.036" "0.918" "0.951" "0.752" "0.802" "0.987" "3.954" "100.9" "101.5" "90.1" "104.6" "92.6" "95.9" "75.8" "80.9" "99.6" "399.0" "" "" "" "" "" "" "" "" "" "" "53.4" "56.3" "51.6" "48.2" "50.1" "53.4" "44.6" "44.2" "55.9" "399.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9115814355814308870" "False" "High" "IsMasterProtein" "P05164" "Myeloperoxidase OS=Homo sapiens OX=9606 GN=MPO PE=1 SV=1" "0.001" "False" "3.073" "1" "1" "1" "1" "745" "83.8" "8.97" "3.13" "1" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03098" "4353" "ENSG00000005381" "MPO" "A1L4B8; hsa:4353; P05164; Q14862; Q4PJH5; Q9UCL7" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Benzene metabolism; Acute myeloid leukemia; Affected pathways in Duchenne muscular dystrophy" "Neutrophil degranulation; Events associated with phagocytolytic activity of PMN cells" "8" "0" "0.990" "1.016" "1.155" "0.899" "1.173" "1.036" "0.923" "0.955" "0.669" "153.3" "151.8" "155.8" "177.1" "137.9" "179.9" "158.8" "141.5" "146.3" "102.6" "" "" "" "" "" "" "" "" "" "" "81.2" "84.2" "89.3" "81.5" "74.6" "100.1" "93.5" "77.2" "82.1" "102.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1957491016862499710" "False" "High" "IsMasterProtein" "P13073" "Cytochrome c oxidase subunit 4 isoform 1, mitochondrial OS=Homo sapiens OX=9606 GN=COX4I1 PE=1 SV=1" "0.001" "False" "3.070" "7" "1" "1" "1" "169" "19.6" "9.51" "2.13" "1" "other metabolic processes;transport" "other membranes;cytosol;mitochondrion;nucleus" "transporter activity" "Pf02936" "1327" "ENSG00000131143" "COX4I1" "B2R4J2; D3DUM7; hsa:1327; P13073; Q6P666" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Mitochondrial protein degradation" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3620399161639766887" "False" "High" "IsMasterProtein" "Q99471" "Prefoldin subunit 5 OS=Homo sapiens OX=9606 GN=PFDN5 PE=1 SV=2" "0.002" "False" "3.066" "5" "1" "1" "1" "154" "17.3" "6.33" "2.37" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf02996" "5204" "ENSG00000123349; ENSG00000291834" "PFDN5" "A8K9A8; hsa:5204; Q54AA8; Q99471; Q9C083; Q9C084" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2743146227967072639" "False" "High" "IsMasterProtein" "Q86WP2" "Vasculin OS=Homo sapiens OX=9606 GN=GPBP1 PE=1 SV=1" "0.002" "False" "3.048" "2" "1" "1" "1" "473" "53.3" "7.05" "2.66" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15337" "65056" "ENSG00000062194" "GPBP1" "A6NKW3; hsa:65056; Q6NSH6; Q86WP2; Q9H0D4; Q9H785; Q9NSN4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2236984144033134213" "False" "High" "IsMasterProtein" "Q9NV70" "Exocyst complex component 1 OS=Homo sapiens OX=9606 GN=EXOC1 PE=1 SV=4" "0.002" "False" "3.046" "1" "1" "1" "1" "894" "101.9" "6.61" "2.78" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf09763, Pf15277, Pf20654" "55763" "ENSG00000090989" "EXOC1" "hsa:55763; Q504V4; Q8WUE7; Q96T15; Q9NV70; Q9NZE4" "Ciliary landscape" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "4" "0" "1.167" "1.189" "1.230" "1.158" "1.105" "1.169" "0.307" "0.966" "5.502" "45.4" "52.9" "53.9" "55.8" "52.5" "50.1" "53.0" "13.9" "43.8" "249.5" "" "" "" "" "" "" "" "" "" "" "24.0" "29.3" "30.9" "25.7" "28.4" "27.9" "31.2" "7.6" "24.6" "249.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1858291838725637521" "False" "High" "IsMasterProtein" "Q14353" "Guanidinoacetate N-methyltransferase OS=Homo sapiens OX=9606 GN=GAMT PE=1 SV=1" "0.002" "False" "3.042" "6" "1" "1" "1" "236" "26.3" "6.14" "1.83" "1" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "" "2593" "ENSG00000130005" "GAMT" "A8K0A0; hsa:2593; Q14353; Q53Y34; Q8WVJ1" "MECP2 and associated Rett syndrome; Creatine pathway" "Transcriptional Regulation by MECP2; Creatine metabolism" "4" "0" "0.981" "0.982" "1.140" "0.988" "1.225" "1.369" "1.130" "1.158" "0.958" "40.7" "39.9" "40.0" "46.4" "40.3" "49.9" "55.8" "46.1" "47.2" "39.0" "" "" "" "" "" "" "" "" "" "" "21.6" "22.1" "22.9" "21.4" "21.8" "27.8" "32.8" "25.1" "26.5" "39.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-621581403936215319" "False" "High" "IsMasterProtein" "Q96B36" "Proline-rich AKT1 substrate 1 OS=Homo sapiens OX=9606 GN=AKT1S1 PE=1 SV=1" "0.002" "False" "3.037" "3" "1" "1" "1" "256" "27.4" "4.75" "2.60" "1" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf15798" "84335" "ENSG00000204673" "AKT1S1" "A8MTQ1; B2RE93; hsa:84335; J3KPM3; Q96B36; Q96BI4; Q96IK7; Q96NG2; Q9BWR5" "Target of rapamycin signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; Thermogenesis; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Thyroid hormones production and peripheral downstream signaling effects; Autophagy; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; p53 transcriptional gene network; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; JAK-STAT signaling in the regulation of beta cells; ADHD and autism (ASD) linked metabolic pathways and SNP" "HSF1-dependent transactivation; Constitutive Signaling by AKT1 E17K in Cancer; mTORC1-mediated signalling; AKT phosphorylates targets in the cytosol" "22" "0" "1.122" "1.034" "0.996" "0.943" "0.971" "1.015" "1.091" "0.995" "0.696" "249.0" "279.3" "257.4" "247.9" "234.7" "241.8" "252.9" "271.6" "247.7" "173.4" "" "" "" "" "" "" "" "" "" "" "131.9" "154.9" "147.4" "114.2" "127.0" "134.5" "148.8" "148.2" "138.9" "173.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2834511568131292996" "False" "High" "IsMasterProtein" "O00329" "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform OS=Homo sapiens OX=9606 GN=PIK3CD PE=1 SV=2" "0.002" "False" "3.033" "1" "1" "1" "1" "1044" "119.4" "7.18" "2.12" "1" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00454, Pf00613, Pf00792, Pf00794, Pf02192" "5293" "ENSG00000171608" "PIK3CD" "A6NCG0; G1FFP1; hsa:5293; O00329; O15445; Q5SR49" "AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; IL-3 signaling pathway; Focal adhesion; Overview of nanoparticle effects; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Nonalcoholic fatty liver disease; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Synaptic signaling pathways associated with autism spectrum disorder; Neural crest cell migration during development; Neural crest cell migration in cancer; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Melanoma; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; G13 signaling pathway; Acute myeloid leukemia; Interferon type I signaling pathways; ErbB signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; PIP3 activates AKT signaling; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL" "56" "0" "1.187" "1.200" "1.122" "1.226" "1.145" "1.097" "1.110" "1.221" "1.199" "55.6" "66.0" "66.7" "62.4" "68.1" "63.6" "61.0" "61.7" "67.9" "66.7" "" "" "" "" "" "" "" "" "" "" "29.4" "36.6" "38.2" "28.7" "36.9" "35.4" "35.9" "33.7" "38.1" "66.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8051417909882487765" "False" "High" "IsMasterProtein" "Q14562" "ATP-dependent RNA helicase DHX8 OS=Homo sapiens OX=9606 GN=DHX8 PE=1 SV=1" "0.002" "False" "3.031" "1" "2" "2" "2" "1220" "139.2" "8.32" "3.94" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00270, Pf00271, Pf00575, Pf04408, Pf07717, Pf21010" "1659" "ENSG00000067596" "DHX8" "hsa:1659; Q14562" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.815" "0.942" "0.987" "1.030" "1.175" "1.622" "1.800" "1.833" "1.375" "96.3" "78.5" "90.7" "95.1" "99.2" "113.2" "156.2" "173.4" "176.5" "132.5" "" "" "" "" "" "" "" "" "" "" "51.0" "43.5" "52.0" "43.8" "53.7" "62.9" "91.9" "94.7" "99.0" "132.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2687801448742430149" "False" "High" "IsMasterProtein" "Q9H4A6" "Golgi phosphoprotein 3 OS=Homo sapiens OX=9606 GN=GOLPH3 PE=1 SV=1" "0.002" "False" "3.029" "5" "2" "2" "2" "298" "33.8" "6.44" "2.19" "2" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05719" "64083" "ENSG00000113384" "GOLPH3" "hsa:64083; Q9H4A6; Q9UIW5" "" "" "0" "0" "1.117" "0.976" "1.063" "1.034" "0.922" "0.902" "1.041" "1.035" "1.113" "173.4" "193.7" "169.3" "184.3" "179.3" "159.9" "156.3" "180.5" "179.5" "193.1" "" "" "" "" "" "" "" "" "" "" "91.8" "107.4" "96.9" "84.9" "97.0" "88.9" "92.0" "98.5" "100.7" "193.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4939449039103849626" "False" "High" "IsMasterProtein" "Q96G74" "OTU domain-containing protein 5 OS=Homo sapiens OX=9606 GN=OTUD5 PE=1 SV=1" "0.002" "False" "3.024" "3" "1" "1" "1" "571" "60.6" "6.54" "1.92" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf02338" "55593" "ENSG00000068308; ENSG00000292211" "OTUD5" "B4DGG7; G5E9D7; hsa:55593; Q4KMN9; Q8N6T5; Q96G74; Q9H650; Q9H9U0; Q9NT65" "Gastric cancer network 2; Novel intracellular components of RIG-I-like receptor pathway" "Negative regulators of DDX58/IFIH1 signaling; Ovarian tumor domain proteases" "4" "0" "1.164" "1.166" "1.282" "1.091" "1.557" "1.119" "0.910" "1.396" "1.815" "27.3" "31.8" "31.8" "35.0" "29.8" "42.5" "30.5" "24.8" "38.1" "49.5" "" "" "" "" "" "" "" "" "" "" "14.5" "17.6" "18.2" "16.1" "16.1" "23.6" "18.0" "13.6" "21.4" "49.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9025151423134884799" "False" "High" "IsMasterProtein" "Q9BY42" "Replication termination factor 2 OS=Homo sapiens OX=9606 GN=RTF2 PE=1 SV=3" "0.002" "False" "3.019" "6" "2" "2" "2" "306" "33.9" "8.59" "4.08" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf04641" "51507" "ENSG00000022277" "RTF2" "E1P5Z9; hsa:51507; Q9BY42; Q9BYL7; Q9HCV9; Q9NX29; Q9NZZ8; Q9P002; Q9UHW3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4972619903535100006" "False" "High" "IsMasterProtein" "P49916" "DNA ligase 3 OS=Homo sapiens OX=9606 GN=LIG3 PE=1 SV=2" "0.002" "False" "3.009" "1" "1" "1" "1" "1009" "112.8" "9.01" "2.86" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00645, Pf01068, Pf04675, Pf04679, Pf16759" "3980" "ENSG00000005156" "LIG3" "E5KLB5; E5KLB6; hsa:3980; P49916; Q16714; Q6NVK3" "Base excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; 17q12 copy number variation syndrome" "Gap-filling DNA repair synthesis and ligation in TC-NER; Gap-filling DNA repair synthesis and ligation in GG-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; HDR through MMEJ (alt-NHEJ); Resolution of AP sites via the single-nucleotide replacement pathway" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9207268972416967358" "False" "High" "IsMasterProtein" "O15066" "Kinesin-like protein KIF3B OS=Homo sapiens OX=9606 GN=KIF3B PE=1 SV=1" "0.002" "False" "3.008" "2" "1" "1" "1" "747" "85.1" "7.69" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "9371" "ENSG00000101350" "KIF3B" "B2RMP4; B4DSR5; E1P5M5; hsa:9371; O15066" "" "Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; MHC class II antigen presentation; Kinesins" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "Not Found" "High" "High" "High" "Not Found" "High" "Not Found" "High" "High" "1" "" "4463024331811541084" "False" "High" "IsMasterProtein" "Q15054" "DNA polymerase delta subunit 3 OS=Homo sapiens OX=9606 GN=POLD3 PE=1 SV=2" "0.002" "False" "3.004" "3" "1" "1" "1" "466" "51.4" "9.35" "2.29" "1" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf09507" "10714" "ENSG00000077514" "POLD3" "B7ZAI6; hsa:10714; Q15054; Q32MZ9; Q32N00" "Homologous recombination; Retinoblastoma gene in cancer; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "HDR through Homologous Recombination (HRR); Termination of translesion DNA synthesis; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "26" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8970901075110106383" "False" "High" "IsMasterProtein" "Q9UL54" "Serine/threonine-protein kinase TAO2 OS=Homo sapiens OX=9606 GN=TAOK2 PE=1 SV=2" "0.002" "False" "3.003" "1" "1" "1" "1" "1235" "138.2" "7.27" "2.62" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "9344" "ENSG00000149930" "TAOK2" "A5PKY1; A7MCZ2; B2RN35; B7ZM88; hsa:9344; O94957; Q6UW73; Q7LC09; Q9NSW2; Q9UL54" "MAPK signaling pathway; VEGFA-VEGFR2 signaling; 16p11.2 proximal deletion syndrome" "" "3" "0" "1.206" "1.258" "1.249" "1.174" "1.188" "1.196" "0.831" "1.111" "2.919" "71.6" "86.4" "90.1" "89.5" "84.1" "85.1" "85.7" "59.5" "79.6" "209.1" "" "" "" "" "" "" "" "" "" "" "37.9" "47.9" "51.6" "41.2" "45.5" "47.3" "50.4" "32.5" "44.6" "209.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4065169870199249389" "False" "High" "IsMasterProtein" "Q86VP1" "Tax1-binding protein 1 OS=Homo sapiens OX=9606 GN=TAX1BP1 PE=1 SV=2" "0.002" "False" "2.997" "2" "2" "2" "2" "789" "90.8" "5.43" "1.64" "2" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07888, Pf17751, Pf18112" "8887" "ENSG00000106052" "TAX1BP1" "A4D196; B4DKU7; E7ENV2; hsa:8887; O60398; O95770; Q13311; Q86VP1; Q9BQG5; Q9UI88" "" "Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling" "2" "0" "1.039" "1.051" "1.011" "1.167" "0.989" "1.024" "1.288" "1.266" "0.915" "147.3" "153.1" "154.8" "148.9" "171.9" "145.6" "150.8" "189.8" "186.6" "134.8" "" "" "" "" "" "" "" "" "" "" "78.0" "84.9" "88.6" "68.6" "93.0" "81.0" "88.7" "103.6" "104.7" "134.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7340038753290804182" "False" "High" "IsMasterProtein" "Q9Y5B9" "FACT complex subunit SPT16 OS=Homo sapiens OX=9606 GN=SUPT16H PE=1 SV=1" "0.002" "False" "2.994" "1" "1" "1" "1" "1047" "119.8" "5.66" "2.82" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf00557, Pf08512, Pf08644, Pf14826, Pf21091" "11198" "ENSG00000092201" "SUPT16H" "hsa:11198; Q6GMT8; Q6P2F1; Q6PJM1; Q9NRX0; Q9Y5B9" "" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2510158146736873084" "False" "High" "IsMasterProtein" "P29084" "Transcription initiation factor IIE subunit beta OS=Homo sapiens OX=9606 GN=GTF2E2 PE=1 SV=1" "0.002" "False" "2.993" "5" "2" "2" "2" "291" "33.0" "9.66" "2.31" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf02186, Pf18121" "2961" "ENSG00000197265" "GTF2E2" "D3DSV2; P29084; Q9H2B9" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "10" "0" "1.279" "1.074" "1.299" "1.229" "1.260" "1.307" "0.974" "1.343" "2.376" "65.8" "84.2" "70.7" "85.5" "80.9" "82.9" "86.0" "64.1" "88.4" "156.4" "" "" "" "" "" "" "" "" "" "" "34.9" "46.7" "40.5" "39.4" "43.8" "46.1" "50.6" "35.0" "49.6" "156.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4482584710342815386" "False" "High" "IsMasterProtein" "Q15773" "Myeloid leukemia factor 2 OS=Homo sapiens OX=9606 GN=MLF2 PE=1 SV=1" "0.002" "False" "2.992" "5" "1" "1" "1" "248" "28.1" "6.90" "2.45" "1" "other biological processes" "nucleus;other cell component" "" "Pf10248" "8079" "ENSG00000089693" "MLF2" "hsa:8079; Q15773" "" "" "0" "0" "1.170" "1.074" "1.299" "1.074" "1.090" "1.107" "0.833" "1.193" "3.740" "32.1" "37.6" "34.5" "41.7" "34.5" "35.0" "35.6" "26.7" "38.3" "120.1" "" "" "" "" "" "" "" "" "" "" "17.0" "20.8" "19.7" "19.2" "18.7" "19.5" "20.9" "14.6" "21.5" "120.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6385363124040609264" "False" "High" "IsMasterProtein" "Q13217" "DnaJ homolog subfamily C member 3 OS=Homo sapiens OX=9606 GN=DNAJC3 PE=1 SV=1" "0.002" "False" "2.991" "2" "1" "1" "1" "504" "57.5" "6.15" "3.25" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00226, Pf00515, Pf13181" "5611" "ENSG00000102580" "DNAJC3" "hsa:5611; Q13217; Q86WT9; Q8N4N2" "Photodynamic therapy-induced unfolded protein response" "Neutrophil degranulation; Viral mRNA Translation; PKR-mediated signaling; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; XBP1(S) activates chaperone genes" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1373534053104032037" "False" "High" "IsMasterProtein" "O14653" "Golgi SNAP receptor complex member 2 OS=Homo sapiens OX=9606 GN=GOSR2 PE=1 SV=2" "0.002" "False" "2.985" "5" "1" "1" "1" "212" "24.8" "8.06" "2.54" "1" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf12352" "9570" "ENSG00000108433" "GOSR2" "D3DXJ5; D3DXJ6; hsa:9570; O14653; Q8N4B8; Q96DA5; Q9BZZ4" "" "COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes; Cargo concentration in the ER" "5" "0" "1.098" "1.120" "1.250" "1.253" "1.063" "1.053" "1.055" "1.231" "0.905" "61.8" "67.8" "69.2" "77.2" "77.5" "65.7" "65.1" "65.2" "76.1" "55.9" "" "" "" "" "" "" "" "" "" "" "32.7" "37.6" "39.6" "35.6" "41.9" "36.6" "38.3" "35.6" "42.7" "55.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9014101916445181907" "False" "High" "IsMasterProtein" "Q6BDS2" "Bridge-like lipid transfer protein family member 3A OS=Homo sapiens OX=9606 GN=BLTP3A PE=1 SV=1" "0.002" "False" "2.981" "1" "1" "1" "1" "1440" "159.4" "6.14" "2.38" "1" "" "other cytoplasmic organelle" "other molecular function" "Pf12624" "54887" "ENSG00000065060" "BLTP3A" "hsa:54887; Q6BDS2; Q9NXE0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7470161461111362497" "False" "High" "IsMasterProtein" "Q7Z4S6" "Kinesin-like protein KIF21A OS=Homo sapiens OX=9606 GN=KIF21A PE=1 SV=2" "0.002" "False" "2.978" "1" "1" "1" "1" "1674" "187.1" "6.42" "2.51" "1" "other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf00400" "55605" "ENSG00000139116" "KIF21A" "A8MX28; B0I1R9; B9EGE4; F5H0C3; F5H219; hsa:55605; Q2UVF1; Q6UKL9; Q7Z4S6; Q7Z668; Q86WZ5; Q8IVZ8; Q9C0F5; Q9NXU4; Q9Y590" "" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5483854635859464991" "False" "High" "IsMasterProtein" "Q9UKK6" "NTF2-related export protein 1 OS=Homo sapiens OX=9606 GN=NXT1 PE=1 SV=1" "0.002" "False" "2.970" "6" "1" "1" "1" "140" "15.8" "5.03" "2.51" "1" "other metabolic processes;transport" "cytosol;nucleus;other cell component" "other molecular function" "Pf02136" "29107" "ENSG00000132661" "NXT1" "hsa:29107; Q9UKK6" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7723860297345747453" "False" "High" "IsMasterProtein" "Q9P266" "Junctional cadherin 5-associated protein OS=Homo sapiens OX=9606 GN=JCAD PE=1 SV=3" "0.002" "False" "2.969" "1" "2" "2" "2" "1359" "148.3" "7.09" "4.53" "2" "cell adhesion;other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf15351" "57608" "ENSG00000165757" "JCAD" "hsa:57608; Q5HYA7; Q5T992; Q86WZ9; Q9BYJ2; Q9P266" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3257917255703740656" "False" "High" "IsMasterProtein" "Q14181" "DNA polymerase alpha subunit B OS=Homo sapiens OX=9606 GN=POLA2 PE=1 SV=2" "0.002" "False" "2.967" "2" "1" "1" "1" "598" "65.9" "5.24" "2.84" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;transport" "cytosol;nucleus" "nucleic acid binding activity" "Pf04042, Pf08418" "23649" "ENSG00000014138" "POLA2" "B4DNB4; hsa:23649; Q14181; Q9BPV3" "Pyrimidine metabolism; G1 to S cell cycle control; DNA replication" "Defective pyroptosis; Activation of the pre-replicative complex; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; DNA replication initiation; Polymerase switching; Removal of the Flap Intermediate" "12" "0" "1.041" "0.982" "1.160" "1.129" "1.221" "1.310" "0.941" "1.084" "3.234" "187.6" "195.3" "184.3" "217.6" "211.8" "229.1" "245.8" "176.6" "203.4" "606.9" "" "" "" "" "" "" "" "" "" "" "99.4" "108.3" "105.5" "100.2" "114.6" "127.4" "144.7" "96.4" "114.1" "606.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5660529774365684631" "False" "High" "IsMasterProtein" "Q6WCQ1" "Myosin phosphatase Rho-interacting protein OS=Homo sapiens OX=9606 GN=MPRIP PE=1 SV=3" "0.002" "False" "2.960" "1" "1" "1" "1" "1025" "116.5" "6.21" "2.39" "1" "" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf00169" "23164" "ENSG00000133030" "MPRIP" "hsa:23164; Q3KQZ5; Q5FB94; Q6DHW2; Q6WCQ1; Q7Z5Y2; Q8N390; Q96G40" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Signaling by BRAF and RAF1 fusions" "2" "0" "0.902" "0.982" "1.106" "1.060" "1.148" "1.003" "0.961" "0.889" "0.908" "68.6" "61.9" "67.4" "75.9" "72.8" "78.8" "68.8" "65.9" "61.0" "62.3" "" "" "" "" "" "" "" "" "" "" "36.3" "34.3" "38.6" "35.0" "39.4" "43.8" "40.5" "36.0" "34.2" "62.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-464578960870386636" "False" "High" "IsMasterProtein" "O43639" "Cytoplasmic protein NCK2 OS=Homo sapiens OX=9606 GN=NCK2 PE=1 SV=2" "0.002" "False" "2.959" "2" "1" "1" "1" "380" "42.9" "6.95" "1.88" "1" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00018, Pf14604" "8440" "ENSG00000071051" "NCK2" "D3DVK1; hsa:8440; O43639; Q9BWN9; Q9UIC3" "Pathogenic Escherichia coli infection; Brain-derived neurotrophic factor (BDNF) signaling pathway; EGF/EGFR signaling pathway; Genes controlling nephrogenesis; ErbB signaling pathway" "RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; Downstream signal transduction; VEGFA-VEGFR2 Pathway; Ephrin signaling; Activation of RAC1; Regulation of cortical dendrite branching" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1849398190907063362" "False" "High" "IsMasterProtein" "P35813" "Protein phosphatase 1A OS=Homo sapiens OX=9606 GN=PPM1A PE=1 SV=1" "0.002" "False" "2.954" "5" "2" "2" "2" "382" "42.4" "5.36" "3.96" "2" "protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf00481, Pf07830" "5494" "ENSG00000100614" "PPM1A" "B5BU11; hsa:5494; J3KNM0; O75551; P35813" "TGF-beta signaling pathway; MAPK signaling pathway" "Energy dependent regulation of mTOR by LKB1-AMPK; Downregulation of SMAD2/3:SMAD4 transcriptional activity" "4" "0" "1.062" "1.010" "1.050" "0.840" "1.088" "1.154" "1.065" "1.005" "1.167" "68.4" "72.7" "69.1" "71.8" "57.5" "74.4" "79.0" "72.9" "68.8" "79.9" "" "" "" "" "" "" "" "" "" "" "36.2" "40.3" "39.6" "33.1" "31.1" "41.4" "46.5" "39.8" "38.6" "79.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-651184813655133351" "False" "High" "IsMasterProtein" "P13807" "Glycogen [starch] synthase, muscle OS=Homo sapiens OX=9606 GN=GYS1 PE=1 SV=2" "0.002" "False" "2.948" "1" "1" "1" "1" "737" "83.7" "6.18" "2.56" "1" "other metabolic processes;developmental processes" "cytosol;other cell component" "other molecular function" "Pf05693" "2997" "ENSG00000104812" "GYS1" "hsa:2997; P13807; Q9BTT9" "AMP-activated protein kinase signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Insulin signaling; Glycogen synthesis and degradation; Disorders of galactose metabolism ; 2q37 copy number variation syndrome" "Glycogen synthesis; Myoclonic epilepsy of Lafora; Glycogen storage disease type XV (GYG1); Glycogen storage disease type 0 (muscle GYS1)" "12" "0" "1.051" "0.953" "1.329" "0.980" "1.020" "1.127" "1.346" "1.065" "0.732" "91.5" "96.2" "87.2" "121.6" "89.6" "93.3" "103.1" "123.2" "97.5" "66.9" "" "" "" "" "" "" "" "" "" "" "48.5" "53.3" "50.0" "56.0" "48.5" "51.9" "60.7" "67.3" "54.7" "66.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9116145290149312693" "False" "High" "IsMasterProtein" "P42226" "Signal transducer and activator of transcription 6 OS=Homo sapiens OX=9606 GN=STAT6 PE=1 SV=1" "0.002" "False" "2.945" "1" "1" "1" "1" "847" "94.1" "6.23" "2.02" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf14596, Pf21354" "6778" "ENSG00000166888" "STAT6" "A8K316; B7ZA27; F5GXI9; hsa:6778; P42226; Q5FBW5; Q71UP4" "Thymic stromal lymphopoietin (TSLP) signaling pathway; Adipogenesis; VEGFA-VEGFR2 signaling; IL-4 signaling pathway; PDGFR-beta pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Neuroinflammation and glutamatergic signaling; Th17 cell differentiation pathway; Inflammatory bowel disease signaling; IL-19 signaling pathway" "Downstream signal transduction; Interleukin-4 and Interleukin-13 signaling; STAT6-mediated induction of chemokines" "13" "0" "1.259" "1.217" "1.753" "1.808" "1.592" "1.506" "1.173" "1.094" "2.669" "28.9" "36.4" "35.2" "50.7" "52.2" "46.0" "43.5" "33.9" "31.6" "77.1" "" "" "" "" "" "" "" "" "" "" "15.3" "20.2" "20.1" "23.3" "28.3" "25.6" "25.6" "18.5" "17.7" "77.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4771647564776910413" "False" "High" "IsMasterProtein" "Q96JC9" "ELL-associated factor 1 OS=Homo sapiens OX=9606 GN=EAF1 PE=1 SV=1" "0.002" "False" "2.940" "5" "1" "1" "1" "268" "29.0" "5.40" "1.78" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09816" "85403" "ENSG00000144597" "EAF1" "B4E3F5; hsa:85403; Q8IW10; Q96JC9" "" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4363739394428502664" "False" "High" "IsMasterProtein" "O75330" "Hyaluronan mediated motility receptor OS=Homo sapiens OX=9606 GN=HMMR PE=1 SV=2" "0.002" "False" "2.939" "2" "2" "2" "2" "724" "84.0" "5.83" "3.69" "2" "other metabolic processes;transport" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf15905, Pf15908" "3161" "ENSG00000072571" "HMMR" "A8K3G2; B4E114; D3DQK9; D3DQL0; E9PCS0; hsa:3161; O75330; Q32N02; Q92767" "" "AURKA Activation by TPX2; Hyaluronan uptake and degradation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2043411241930693309" "False" "High" "IsMasterProtein" "Q96JM3" "Chromosome alignment-maintaining phosphoprotein 1 OS=Homo sapiens OX=9606 GN=CHAMP1 PE=1 SV=2" "0.002" "False" "2.936" "2" "2" "2" "2" "812" "89.0" "8.44" "1.91" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "" "283489" "ENSG00000198824" "CHAMP1" "B3KU06; hsa:283489; Q6P181; Q8NC88; Q96JM3; Q9BST0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1657262686538344528" "False" "High" "IsMasterProtein" "O75717" "WD repeat and HMG-box DNA-binding protein 1 OS=Homo sapiens OX=9606 GN=WDHD1 PE=1 SV=1" "0.002" "False" "2.933" "1" "2" "2" "2" "1129" "125.9" "5.62" "4.67" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12341, Pf12894, Pf20946" "11169" "ENSG00000198554" "WDHD1" "C9JW18; F6W0U7; hsa:11169; O75717" "Mesodermal commitment pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8586542513876721198" "False" "High" "IsMasterProtein" "O43502" "DNA repair protein RAD51 homolog 3 OS=Homo sapiens OX=9606 GN=RAD51C PE=1 SV=1" "0.002" "False" "2.930" "3" "1" "1" "1" "376" "42.2" "6.74" "2.28" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423" "5889" "ENSG00000108384" "RAD51C" "hsa:5889; O43502; O43503; Q3B783" "DNA repair pathways, full network" "Resolution of D-loop Structures through Holliday Junction Intermediates; Factors involved in megakaryocyte development and platelet production; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination" "12" "0" "1.474" "0.965" "1.459" "1.043" "1.155" "1.298" "0.851" "1.074" "0.755" "41.1" "60.6" "39.7" "60.0" "42.9" "47.5" "53.4" "35.0" "44.2" "31.1" "" "" "" "" "" "" "" "" "" "" "21.8" "33.6" "22.7" "27.6" "23.2" "26.4" "31.4" "19.1" "24.8" "31.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2081784358139501247" "False" "High" "IsMasterProtein" "Q96ME1" "F-box/LRR-repeat protein 18 OS=Homo sapiens OX=9606 GN=FBXL18 PE=1 SV=3" "0.002" "False" "2.928" "2" "1" "1" "1" "718" "78.9" "8.27" "2.53" "1" "protein metabolism;other metabolic processes" "cytosol;other cell component" "" "Pf12937, Pf19729" "80028" "ENSG00000155034" "FBXL18" "A0A024R857; B3KTC9; B4DH63; H0Y6I6; hsa:80028; Q96ME1; Q9BR90; Q9BTC7; Q9HAK7" "" "Antigen processing: Ubiquitination & Proteasome degradation; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Neddylation" "3" "0" "1.111" "1.062" "1.120" "0.993" "0.927" "1.018" "0.970" "1.126" "1.245" "83.3" "92.5" "88.5" "93.3" "82.7" "77.2" "84.8" "80.8" "93.8" "103.7" "" "" "" "" "" "" "" "" "" "" "44.1" "51.3" "50.7" "43.0" "44.7" "43.0" "49.9" "44.1" "52.6" "103.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5797732752713602243" "False" "High" "IsMasterProtein" "Q15050" "Ribosome biogenesis regulatory protein homolog OS=Homo sapiens OX=9606 GN=RRS1 PE=1 SV=2" "0.002" "False" "2.924" "2" "1" "1" "1" "365" "41.2" "10.70" "2.48" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf04939" "23212" "ENSG00000179041" "RRS1" "hsa:23212; Q15050; Q9BUX8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8346227288620115762" "False" "High" "IsMasterProtein" "Q86TN4" "tRNA 2'-phosphotransferase 1 OS=Homo sapiens OX=9606 GN=TRPT1 PE=1 SV=2" "0.002" "False" "2.917" "4" "1" "1" "1" "253" "27.7" "9.98" "2.10" "1" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf01885" "83707" "ENSG00000149743" "TRPT1" "A8MU17; A8MYC9; F5H2B2; hsa:83707; Q86TN4; Q9BSB9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1224070834007844842" "False" "High" "IsMasterProtein" "Q9BW91" "ADP-ribose pyrophosphatase, mitochondrial OS=Homo sapiens OX=9606 GN=NUDT9 PE=1 SV=1" "0.002" "False" "2.916" "3" "1" "1" "1" "350" "39.1" "8.22" "0.00" "1" "other metabolic processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00293" "53343" "ENSG00000170502" "NUDT9" "hsa:53343; Q8NBN1; Q8NCB9; Q8NG25; Q9BW91" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5455074280924099638" "False" "High" "IsMasterProtein" "Q15554" "Telomeric repeat-binding factor 2 OS=Homo sapiens OX=9606 GN=TERF2 PE=1 SV=3" "0.002" "False" "2.912" "1" "1" "1" "1" "542" "59.6" "9.35" "2.47" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf08558, Pf16772" "7014" "ENSG00000132604" "TERF2" "hsa:7014; Q15554" "Hematopoietic stem cell gene regulation by GABP alpha/beta complex; DNA repair pathways, full network; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "Meiotic synapsis; Telomere Extension By Telomerase; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; DNA Damage/Telomere Stress Induced Senescence; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; Removal of the Flap Intermediate from the C-strand" "17" "0" "1.019" "0.886" "0.914" "0.878" "0.892" "1.009" "0.781" "0.848" "2.980" "111.7" "113.9" "99.0" "102.1" "98.1" "99.6" "112.7" "87.3" "94.7" "332.8" "" "" "" "" "" "" "" "" "" "" "59.1" "63.1" "56.7" "47.0" "53.1" "55.4" "66.3" "47.6" "53.1" "332.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6970631393786121187" "False" "High" "IsMasterProtein" "Q8WU79" "Stromal membrane-associated protein 2 OS=Homo sapiens OX=9606 GN=SMAP2 PE=1 SV=1" "0.002" "False" "2.910" "3" "1" "1" "1" "429" "46.8" "8.87" "3.25" "1" "" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01412" "64744" "ENSG00000084070" "SMAP2" "B2R7T1; B7Z5B5; B7Z8V2; D3DPV2; hsa:64744; Q5QPL2; Q8WU79; Q96C93; Q9NST2; Q9UJL8" "" "" "0" "0" "1.033" "1.051" "1.159" "1.017" "0.961" "1.155" "1.155" "0.967" "0.794" "204.3" "211.0" "214.7" "236.7" "207.8" "196.3" "235.9" "236.1" "197.6" "162.1" "" "" "" "" "" "" "" "" "" "" "108.2" "117.0" "123.0" "109.0" "112.4" "109.2" "138.8" "128.9" "110.9" "162.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-776165374606149247" "False" "High" "IsMasterProtein" "Q99547" "M-phase phosphoprotein 6 OS=Homo sapiens OX=9606 GN=MPHOSPH6 PE=1 SV=2" "0.002" "False" "2.902" "5" "1" "2" "1" "160" "19.0" "5.20" "4.47" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf10175" "10200" "ENSG00000135698" "MPHOSPH6" "B2RAF0; hsa:10200; Q99547" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5608231469546375684" "False" "High" "IsMasterProtein" "O00161" "Synaptosomal-associated protein 23 OS=Homo sapiens OX=9606 GN=SNAP23 PE=1 SV=1" "0.002" "False" "2.897" "5" "1" "1" "1" "211" "23.3" "5.01" "3.14" "1" "cell-cell signaling;cell organization and biogenesis;stress response;transport" "plasma membrane;other membranes;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00835" "8773" "ENSG00000092531" "SNAP23" "hsa:8773; O00161; O00162; Q13602; Q6IAE3" "Insulin signaling" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; ER-Phagosome pathway; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; trans-Golgi Network Vesicle Budding" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8474719942598486325" "False" "High" "IsMasterProtein" "Q8WYA6" "Beta-catenin-like protein 1 OS=Homo sapiens OX=9606 GN=CTNNBL1 PE=1 SV=1" "0.002" "False" "2.896" "1" "1" "1" "1" "563" "65.1" "5.05" "2.38" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08216" "56259" "ENSG00000132792" "CTNNBL1" "B4DE16; hsa:56259; Q0VAL9; Q0VAM0; Q53HI8; Q5JWZ2; Q5JWZ3; Q5JWZ7; Q5JWZ8; Q8N454; Q8NCL2; Q8TBD6; Q8WYA6; Q96KD2; Q9H7A5; Q9NQF9; Q9NTX0; Q9Y3M7" "" "mRNA Splicing - Major Pathway" "1" "0" "0.829" "1.235" "0.934" "0.955" "0.882" "1.498" "0.583" "1.517" "11.453" "34.5" "28.6" "42.6" "32.2" "33.0" "30.5" "51.7" "20.1" "52.4" "395.3" "" "" "" "" "" "" "" "" "" "" "18.3" "15.9" "24.4" "14.9" "17.8" "16.9" "30.4" "11.0" "29.4" "395.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-775611795353196892" "False" "High" "IsMasterProtein" "Q86XI2" "Condensin-2 complex subunit G2 OS=Homo sapiens OX=9606 GN=NCAPG2 PE=1 SV=1" "0.002" "False" "2.892" "1" "1" "2" "1" "1143" "130.9" "6.87" "5.27" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12422" "54892" "ENSG00000146918" "NCAPG2" "A4D228; hsa:54892; Q7Z3J9; Q86XI2; Q8WUG8; Q9BRX6; Q9H8S2; Q9H9K6" "Mesodermal commitment pathway" "Condensation of Prophase Chromosomes" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "587629030482776779" "False" "High" "IsMasterProtein" "Q5VZM2" "Ras-related GTP-binding protein B OS=Homo sapiens OX=9606 GN=RRAGB PE=1 SV=1" "0.002" "False" "2.892" "2" "1" "1" "1" "374" "43.2" "6.21" "1.65" "1" "stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04670" "10325" "ENSG00000083750" "RRAGB" "A8K042; hsa:10325; Q15348; Q5VZM2; Q8N3T0" "Target of rapamycin signaling; 2q37 copy number variation syndrome" "Macroautophagy; TP53 Regulates Metabolic Genes; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling; Energy dependent regulation of mTOR by LKB1-AMPK" "9" "0" "1.019" "0.879" "1.044" "1.043" "0.921" "0.906" "0.935" "0.970" "0.586" "94.9" "96.7" "83.4" "99.1" "99.0" "87.5" "86.0" "88.7" "92.0" "55.6" "" "" "" "" "" "" "" "" "" "" "50.3" "53.6" "47.8" "45.6" "53.6" "48.7" "50.6" "48.4" "51.6" "55.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1023835603968378243" "False" "High" "IsMasterProtein" "O75506" "Heat shock factor-binding protein 1 OS=Homo sapiens OX=9606 GN=HSBP1 PE=1 SV=1" "0.002" "False" "2.883" "14" "1" "1" "1" "76" "8.5" "4.36" "1.76" "1" "stress response;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06825" "3281" "ENSG00000230989" "HSBP1" "hsa:3281; O75506; Q53XA8; Q7Z5Z3" "" "HSF1 activation; Attenuation phase" "3" "0" "1.620" "1.373" "1.372" "1.345" "1.316" "1.556" "1.694" "1.767" "1.110" "54.4" "88.1" "74.6" "74.6" "73.2" "71.6" "84.6" "92.1" "96.1" "60.4" "" "" "" "" "" "" "" "" "" "" "28.8" "48.8" "42.7" "34.4" "39.6" "39.8" "49.8" "50.3" "53.9" "60.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3725331180764852423" "False" "High" "IsMasterProtein" "Q9ULR3" "Protein phosphatase 1H OS=Homo sapiens OX=9606 GN=PPM1H PE=1 SV=2" "0.002" "False" "2.883" "2" "1" "1" "1" "514" "56.4" "6.60" "2.66" "1" "" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00481" "57460" "ENSG00000111110" "PPM1H" "B1Q2A9; B2RXG4; hsa:57460; Q6PI86; Q9ULR3" "" "" "0" "0" "0.886" "0.936" "0.956" "0.986" "0.979" "0.952" "1.082" "1.049" "0.939" "202.5" "179.3" "189.5" "193.6" "199.6" "198.2" "192.7" "219.1" "212.4" "190.1" "" "" "" "" "" "" "" "" "" "" "107.2" "99.4" "108.5" "89.2" "108.0" "110.3" "113.4" "119.6" "119.2" "190.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "582663252060756755" "False" "High" "IsMasterProtein" "Q9NVX7" "Kelch repeat and BTB domain-containing protein 4 OS=Homo sapiens OX=9606 GN=KBTBD4 PE=1 SV=4" "0.002" "False" "2.875" "1" "1" "1" "1" "534" "59.9" "5.77" "2.72" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "1.261" "1.042" "1.194" "1.285" "1.170" "1.266" "1.188" "1.025" "0.840" "178.8" "225.5" "186.3" "213.4" "229.7" "209.1" "226.4" "212.5" "183.3" "150.3" "" "" "" "" "" "" "" "" "" "" "94.7" "125.0" "106.7" "98.3" "124.3" "116.3" "133.3" "116.0" "102.8" "150.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5468986810261152963" "False" "High" "IsMasterProtein" "Q15334" "Lethal(2) giant larvae protein homolog 1 OS=Homo sapiens OX=9606 GN=LLGL1 PE=1 SV=3" "0.002" "False" "2.869" "1" "1" "1" "1" "1064" "115.3" "6.29" "2.46" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf08366" "3996" "ENSG00000131899" "LLGL1" "A7MBM7; hsa:3996; O00188; Q15334; Q58F11; Q86UK6" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "" "1" "0" "1.211" "1.103" "1.179" "1.025" "1.063" "1.033" "1.051" "0.987" "1.085" "66.6" "80.7" "73.5" "78.6" "68.3" "70.8" "68.8" "70.0" "65.8" "72.3" "" "" "" "" "" "" "" "" "" "" "35.3" "44.7" "42.1" "36.2" "37.0" "39.4" "40.5" "38.2" "36.9" "72.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3032211375385727038" "False" "High" "IsMasterProtein" "Q15388" "Mitochondrial import receptor subunit TOM20 homolog OS=Homo sapiens OX=9606 GN=TOMM20 PE=1 SV=1" "0.002" "False" "2.861" "9" "1" "1" "1" "145" "16.3" "8.60" "0.00" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;mitochondrion;other cell component" "transporter activity;other molecular function" "Pf02064" "9804" "ENSG00000173726" "TOMM20" "A8K195; hsa:9804; Q15388; Q498B3; Q6IBT4" "" "Ub-specific processing proteases; Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6993572615210098163" "False" "High" "IsMasterProtein" "Q9UJV9" "Probable ATP-dependent RNA helicase DDX41 OS=Homo sapiens OX=9606 GN=DDX41 PE=1 SV=2" "0.002" "False" "2.859" "2" "1" "1" "1" "622" "69.8" "6.84" "2.93" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00270, Pf00271" "51428" "ENSG00000183258" "DDX41" "B2RDC8; Q96BK6; Q96K05; Q9NT96; Q9NW04; Q9UJV9" "5q35 copy number variation" "mRNA Splicing - Major Pathway; Regulation of innate immune responses to cytosolic DNA; IRF3-mediated induction of type I IFN" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5762449723745155897" "False" "High" "IsMasterProtein" "Q9H5V9" "STING ER exit protein OS=Homo sapiens OX=9606 GN=STEEP1 PE=1 SV=1" "0.002" "False" "2.858" "5" "1" "1" "1" "222" "25.6" "8.73" "3.03" "1" "cell organization and biogenesis;transport" "cytoskeleton;nucleus;other cell component" "" "" "63932" "ENSG00000018610" "STEEP1" "A8MPX7; B4DQN2; D3DWH9; F5GWL7; hsa:63932; O43351; Q9H5V9" "" "mRNA Splicing - Major Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7100203530818565223" "False" "High" "IsMasterProtein" "O00443" "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha OS=Homo sapiens OX=9606 GN=PIK3C2A PE=1 SV=2" "0.002" "False" "2.857" "0" "1" "1" "1" "1686" "190.6" "8.02" "2.86" "1" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00168, Pf00454, Pf00613, Pf00787, Pf00792, Pf00794" "5286" "ENSG00000011405" "PIK3C2A" "B0LPH2; B4E2G4; hsa:5286; O00443; Q14CQ9" "Glioblastoma signaling pathways; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; Osteoblast differentiation and related diseases; Insulin signaling; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)" "Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8654405548002230634" "False" "High" "IsMasterProtein" "Q49B96" "Cytochrome c oxidase assembly protein COX19 OS=Homo sapiens OX=9606 GN=COX19 PE=1 SV=1" "0.002" "False" "2.854" "14" "1" "1" "1" "90" "10.4" "8.72" "2.13" "1" "cell organization and biogenesis;other biological processes" "cytosol;mitochondrion" "" "Pf06747" "90639" "ENSG00000240230" "COX19" "A4FTX0; hsa:90639; Q49B96" "Mitochondrial complex IV assembly" "Cytoprotection by HMOX1; Respiratory electron transport; TP53 Regulates Metabolic Genes; Mitochondrial protein import" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1360420814074918380" "False" "High" "IsMasterProtein" "Q5T653" "Large ribosomal subunit protein uL2m OS=Homo sapiens OX=9606 GN=MRPL2 PE=1 SV=2" "0.002" "False" "2.853" "4" "1" "1" "1" "305" "33.3" "11.30" "2.84" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf00181, Pf03947" "51069" "ENSG00000112651" "MRPL2" "B2RC56; hsa:51069; Q5T653; Q8WUL1; Q96Q56; Q9Y311" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-11749500110992675" "False" "High" "IsMasterProtein" "Q92995" "Ubiquitin carboxyl-terminal hydrolase 13 OS=Homo sapiens OX=9606 GN=USP13 PE=1 SV=2" "0.002" "False" "2.847" "1" "1" "1" "1" "863" "97.3" "5.53" "2.73" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00443, Pf00627, Pf02148, Pf17807" "8975" "ENSG00000058056" "USP13" "A8K2S3; B4DYF3; D3DNS2; hsa:8975; Q92995; Q96B25" "" "Ub-specific processing proteases; Regulation of PTEN stability and activity" "2" "0" "1.005" "0.930" "0.984" "1.025" "1.014" "1.071" "0.849" "1.069" "2.661" "185.0" "186.0" "172.1" "182.0" "189.6" "187.6" "198.2" "157.1" "197.9" "492.3" "" "" "" "" "" "" "" "" "" "" "98.0" "103.1" "98.6" "83.8" "102.6" "104.4" "116.7" "85.7" "111.0" "492.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5026099811254189140" "False" "High" "IsMasterProtein" "P11166" "Solute carrier family 2, facilitated glucose transporter member 1 OS=Homo sapiens OX=9606 GN=SLC2A1 PE=1 SV=2" "0.003" "False" "2.822" "3" "1" "1" "1" "492" "54.0" "8.72" "2.10" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00083" "6513" "ENSG00000117394" "SLC2A1" "A8K9S6; B2R620; D3DPX0; hsa:6513; O75535; P11166; Q0P512; Q147X2" "Cori cycle; HIF1A and PPARG regulation of glycolysis; Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced HIF-1 survival signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; Hereditary leiomyomatosis and renal cell carcinoma pathway; Type 2 papillary renal cell carcinoma; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Insulin signaling; Proximal tubule transport; p53 transcriptional gene network; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Glucose metabolism in triple-negative breast cancer cells; Amino acid metabolism in triple-negative breast cancer cells; Warburg effect modulated by deubiquitinating enzymes and their substrates; Chronic hyperglycemia impairment of neuron function; Glycolysis and gluconeogenesis; Macrophage-stimulating protein (MSP) signaling network map; Metabolic Epileptic Disorders; Pancreatic cancer subtypes; 15q25 copy number variation; GLP-1 in pancreatic islet cells; GLP-1 from intestine and pancreas and role in glucose homeostasis" "Cellular hexose transport; Regulation of insulin secretion; Vitamin C (ascorbate) metabolism; Lactose synthesis; Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)" "36" "0" "0.978" "1.166" "0.898" "1.077" "1.013" "1.008" "1.026" "0.803" "0.766" "55.0" "53.8" "64.1" "49.4" "59.2" "55.7" "55.4" "56.4" "44.2" "42.1" "" "" "" "" "" "" "" "" "" "" "29.1" "29.8" "36.7" "22.7" "32.0" "31.0" "32.6" "30.8" "24.8" "42.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3529380218292263569" "False" "High" "IsMasterProtein" "P05423" "DNA-directed RNA polymerase III subunit RPC4 OS=Homo sapiens OX=9606 GN=POLR3D PE=1 SV=2" "0.003" "False" "2.811" "3" "1" "1" "1" "398" "44.4" "6.98" "2.97" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05132" "661" "ENSG00000168495" "POLR3D" "hsa:661; P05423; Q6FI28; Q9BPV7; Q9BPZ1; Q9BXB3" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2450286954911087625" "False" "High" "IsMasterProtein" "O43325" "LYR motif-containing protein 1 OS=Homo sapiens OX=9606 GN=LYRM1 PE=1 SV=1" "0.003" "False" "2.809" "7" "1" "1" "1" "122" "14.3" "9.94" "2.85" "1" "" "nucleus;other cell component" "" "Pf05347" "57149" "ENSG00000102897" "LYRM1" "B2R4M5; hsa:57149; O43325" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8619472182958520531" "False" "High" "IsMasterProtein" "P61960" "Ubiquitin-fold modifier 1 OS=Homo sapiens OX=9606 GN=UFM1 PE=1 SV=1" "0.003" "False" "2.806" "18" "2" "2" "2" "85" "9.1" "9.31" "4.29" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "ER/Golgi;nucleus;other cell component" "" "Pf03671" "51569" "ENSG00000120686" "UFM1" "hsa:51569; P61960; Q14346; Q5VXS0; Q6IAG6; Q9CPX2; Q9NZF2" "" "" "0" "0" "0.920" "0.810" "1.094" "0.863" "0.661" "0.977" "1.047" "0.890" "0.551" "80.5" "74.0" "65.2" "88.0" "69.4" "53.2" "78.6" "84.3" "71.6" "44.3" "" "" "" "" "" "" "" "" "" "" "42.6" "41.1" "37.3" "40.5" "37.6" "29.6" "46.2" "46.0" "40.2" "44.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1948996399981661341" "False" "High" "IsMasterProtein" "Q2TAL8" "Transcriptional regulator QRICH1 OS=Homo sapiens OX=9606 GN=QRICH1 PE=1 SV=1" "0.003" "False" "2.805" "1" "1" "1" "1" "776" "86.4" "5.87" "2.98" "1" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf12012" "54870" "ENSG00000198218" "QRICH1" "hsa:54870; Q2TAL8; Q4G0F7; Q7L621; Q8TEA5" "" "" "0" "0" "1.178" "1.068" "1.322" "1.178" "1.274" "1.622" "1.499" "1.706" "6.087" "72.8" "85.8" "77.8" "96.3" "85.8" "92.8" "118.2" "109.2" "124.3" "443.4" "" "" "" "" "" "" "" "" "" "" "38.6" "47.6" "44.6" "44.4" "46.4" "51.6" "69.6" "59.6" "69.7" "443.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1703927075416448593" "False" "High" "IsMasterProtein" "P07477" "Serine protease 1 OS=Homo sapiens OX=9606 GN=PRSS1 PE=1 SV=1" "0.003" "False" "2.803" "8" "1" "1" "1" "247" "26.5" "6.51" "0.00" "1" "cell organization and biogenesis;protein metabolism;other biological processes" "non-structural extracellular" "other molecular function" "Pf00089" "5644" "ENSG00000204983; ENSG00000274247" "PRSS1" "A1A509; A6NJ71; B2R5I5; hsa:5644; P07477; Q5NV57; Q7M4N3; Q7M4N4; Q92955; Q9HAN4; Q9HAN5; Q9HAN6; Q9HAN7" "" "Uptake of dietary cobalamins into enterocytes; Activation of Matrix Metalloproteinases" "2" "0" "0.741" "1.103" "1.026" "0.906" "0.884" "1.028" "0.873" "1.092" "0.829" "72.2" "53.5" "79.7" "74.1" "65.5" "63.9" "74.3" "63.1" "78.9" "59.9" "" "" "" "" "" "" "" "" "" "" "38.3" "29.7" "45.6" "34.1" "35.4" "35.5" "43.7" "34.4" "44.2" "59.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2137226823831967498" "False" "High" "IsMasterProtein" "Q0VD83" "Apolipoprotein B receptor OS=Homo sapiens OX=9606 GN=APOBR PE=1 SV=3" "0.003" "False" "2.797" "1" "1" "1" "1" "1097" "115.6" "4.40" "2.42" "1" "other metabolic processes;transport" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "" "55911" "ENSG00000184730" "APOBR" "H3BU97; hsa:55911; Q0VD81; Q0VD83; Q8NC15; Q9NPJ9" "" "VLDL clearance" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4502838028789951010" "False" "High" "IsMasterProtein" "P51397" "Death-associated protein 1 OS=Homo sapiens OX=9606 GN=DAP PE=1 SV=3" "0.003" "False" "2.795" "8" "1" "7" "1" "102" "11.2" "9.32" "15.02" "1" "other metabolic processes;stress response;signal transduction;other biological processes" "" "other molecular function" "Pf15228" "1611" "ENSG00000112977" "DAP" "hsa:1611; P51397; Q6FGC3; Q9BUC9" "" "" "0" "0" "1.180" "1.045" "1.072" "1.033" "0.865" "0.953" "1.163" "0.993" "0.546" "64.2" "75.8" "67.1" "68.9" "66.3" "55.5" "61.2" "74.7" "63.8" "35.1" "" "" "" "" "" "" "" "" "" "" "34.0" "42.0" "38.4" "31.7" "35.9" "30.9" "36.0" "40.8" "35.8" "35.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-631503824976752333" "False" "High" "IsMasterProtein" "Q9BYD2" "Large ribosomal subunit protein bL9m OS=Homo sapiens OX=9606 GN=MRPL9 PE=1 SV=2" "0.003" "False" "2.793" "3" "1" "1" "1" "267" "30.2" "10.08" "2.91" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01281" "65005" "ENSG00000143436" "MRPL9" "B2RD99; hsa:65005; Q5SZR2; Q9BSW8; Q9BYD2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.949" "1.011" "0.994" "1.035" "0.984" "0.791" "0.738" "0.784" "1.211" "199.7" "189.4" "201.8" "198.5" "206.7" "196.6" "157.9" "147.3" "156.5" "241.7" "" "" "" "" "" "" "" "" "" "" "105.7" "105.0" "115.6" "91.4" "111.8" "109.3" "92.9" "80.4" "87.8" "241.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4477841957846680674" "False" "High" "IsMasterProtein" "Q8IZL2" "Mastermind-like protein 2 OS=Homo sapiens OX=9606 GN=MAML2 PE=1 SV=2" "0.003" "False" "2.788" "1" "1" "1" "1" "1156" "125.1" "9.42" "2.99" "1" "signal transduction;other biological processes" "nucleus" "other molecular function" "Pf09596, Pf20804" "84441" "ENSG00000184384" "MAML2" "A7MD26; hsa:84441; Q6AI23; Q6Y3A3; Q8IUL3; Q8IZL2; Q96JK6" "Canonical and non-canonical Notch signaling; Notch signaling pathway" "Pre-NOTCH Transcription and Translation; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH2 intracellular domain regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3380259188437483549" "False" "High" "IsMasterProtein" "Q9NQ88" "Fructose-2,6-bisphosphatase TIGAR OS=Homo sapiens OX=9606 GN=TIGAR PE=1 SV=1" "0.003" "False" "2.787" "3" "1" "1" "1" "270" "30.0" "7.69" "2.69" "1" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00300" "57103" "ENSG00000078237" "TIGAR" "B2R840; hsa:57103; Q9NQ88" "Metabolic reprogramming in colon cancer; p53 transcriptional gene network" "TP53 Regulates Metabolic Genes" "3" "0" "0.905" "0.850" "1.022" "1.096" "0.977" "1.180" "0.720" "1.178" "1.352" "73.5" "66.5" "62.5" "75.1" "80.6" "71.8" "86.7" "52.9" "86.6" "99.4" "" "" "" "" "" "" "" "" "" "" "38.9" "36.9" "35.8" "34.6" "43.6" "40.0" "51.1" "28.9" "48.6" "99.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2085339884306235514" "False" "High" "IsMasterProtein" "Q13501" "Sequestosome-1 OS=Homo sapiens OX=9606 GN=SQSTM1 PE=1 SV=1" "0.003" "False" "2.777" "3" "1" "2" "1" "440" "47.7" "5.22" "1.73" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00564, Pf00569, Pf16577" "8878" "ENSG00000161011; ENSG00000284099" "SQSTM1" "A6NFN7; B2R661; B3KUW5; hsa:8878; Q13446; Q13501; Q9BUV7; Q9BVS6; Q9UEU1" "IL-1 signaling pathway; RANKL/RANK signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Nuclear receptors meta-pathway; NRF2 pathway; Interleukin-1 induced activation of NF-kB; Clear cell renal cell carcinoma pathways; CAMKK2 pathway; 7q11.23 copy number variation syndrome; Opioid receptor pathways; Clock-controlled autophagy in bone metabolism; Autophagy in pancreatic ductal adenocarcinoma; HDAC6 interactions in the central nervous system" "Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Signaling by ALK fusions and activated point mutants; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; Nuclear events mediated by NFE2L2; PINK1-PRKN Mediated Mitophagy; NRIF signals cell death from the nucleus; Pexophagy" "24" "0" "1.360" "1.338" "1.624" "1.834" "1.356" "1.272" "1.419" "1.758" "1.071" "15.9" "21.6" "21.2" "25.7" "29.1" "21.5" "20.2" "22.5" "27.9" "17.0" "" "" "" "" "" "" "" "" "" "" "8.4" "12.0" "12.1" "11.9" "15.7" "12.0" "11.9" "12.3" "15.6" "17.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9163044576809599647" "False" "High" "IsMasterProtein" "P0DPB6" "DNA-directed RNA polymerases I and III subunit RPAC2 OS=Homo sapiens OX=9606 GN=POLR1D PE=1 SV=1" "0.003" "False" "2.777" "10" "1" "1" "1" "133" "15.2" "5.80" "1.95" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01193, Pf13656" "51082" "ENSG00000186184" "POLR1D" "hsa:51082; P0DPB6; Q5TBX2; Q96BR3; Q9Y2S0" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "" "4" "0" "1.119" "0.818" "1.087" "1.524" "1.504" "1.395" "0.845" "1.223" "6.305" "18.1" "20.3" "14.8" "19.7" "27.6" "27.2" "25.2" "15.3" "22.1" "114.1" "" "" "" "" "" "" "" "" "" "" "9.6" "11.2" "8.5" "9.1" "14.9" "15.1" "14.9" "8.3" "12.4" "114.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1072346070458958756" "False" "High" "IsMasterProtein" "Q8N2H3" "Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PYROXD2 PE=1 SV=2" "0.003" "False" "2.777" "1" "1" "1" "1" "581" "63.0" "6.95" "2.14" "1" "cell organization and biogenesis" "mitochondrion" "other molecular function" "Pf01593, Pf13450" "84795" "ENSG00000119943" "PYROXD2" "D3DR61; hsa:84795; Q5TAA9; Q8N2H3; Q9BRQ1" "" "" "0" "0" "1.375" "1.051" "1.184" "1.081" "1.030" "1.508" "1.723" "1.557" "0.562" "94.5" "129.9" "99.3" "111.9" "102.2" "97.4" "142.5" "162.8" "147.1" "53.1" "" "" "" "" "" "" "" "" "" "" "50.0" "72.0" "56.9" "51.6" "55.3" "54.2" "83.9" "88.9" "82.5" "53.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8383359941094889164" "False" "High" "IsMasterProtein" "Q9NV35" "Nucleotide triphosphate diphosphatase NUDT15 OS=Homo sapiens OX=9606 GN=NUDT15 PE=1 SV=1" "0.003" "False" "2.776" "6" "1" "1" "1" "164" "18.6" "6.14" "2.33" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol" "other molecular function" "Pf00293" "55270" "ENSG00000136159" "NUDT15" "A2RUR6; hsa:55270; Q32Q27; Q6P2C9; Q9NV35" "" "Azathioprine ADME; Phosphate bond hydrolysis by NUDT proteins" "2" "0" "1.067" "1.205" "1.037" "1.182" "1.305" "1.058" "1.144" "1.200" "0.950" "171.0" "182.5" "205.9" "177.2" "202.1" "223.1" "181.0" "195.5" "205.1" "162.4" "" "" "" "" "" "" "" "" "" "" "90.5" "101.2" "117.9" "81.6" "109.4" "124.1" "106.5" "106.7" "115.1" "162.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8452486629110953776" "False" "High" "IsMasterProtein" "Q9BVC6" "Voltage-gated monoatomic cation channel TMEM109 OS=Homo sapiens OX=9606 GN=TMEM109 PE=1 SV=1" "0.003" "False" "2.775" "5" "1" "1" "1" "243" "26.2" "10.48" "2.30" "1" "stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus" "transporter activity" "Pf14965" "79073" "ENSG00000110108" "TMEM109" "hsa:79073; Q9BVC6" "" "" "0" "0" "1.022" "1.062" "1.337" "1.268" "1.332" "1.157" "0.810" "0.904" "0.967" "41.5" "42.5" "44.1" "55.6" "52.7" "55.3" "48.0" "33.6" "37.6" "40.2" "" "" "" "" "" "" "" "" "" "" "22.0" "23.5" "25.3" "25.6" "28.5" "30.8" "28.3" "18.4" "21.1" "40.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4814206487852124286" "False" "High" "IsMasterProtein" "Q9H7S9" "Zinc finger protein 703 OS=Homo sapiens OX=9606 GN=ZNF703 PE=1 SV=1" "0.003" "False" "2.771" "3" "1" "1" "1" "590" "58.2" "8.79" "2.11" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12402" "80139" "ENSG00000183779" "ZNF703" "hsa:80139; Q5XG76; Q9H7S9" "" "Generic Transcription Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5201863361074030149" "False" "High" "IsMasterProtein" "O95071" "E3 ubiquitin-protein ligase UBR5 OS=Homo sapiens OX=9606 GN=UBR5 PE=1 SV=2" "0.003" "False" "2.769" "0" "1" "1" "1" "2799" "309.2" "5.85" "2.87" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00632, Pf00658, Pf11547" "51366" "ENSG00000104517" "UBR5" "B2RP24; hsa:51366; J3KMW7; O94970; O95071; Q9NPL3" "Mesodermal commitment pathway" "" "1" "0" "1.247" "1.031" "1.020" "1.413" "1.296" "1.045" "1.105" "1.344" "6.129" "24.3" "30.3" "25.0" "24.8" "34.3" "31.5" "25.4" "26.8" "32.6" "148.8" "" "" "" "" "" "" "" "" "" "" "12.9" "16.8" "14.3" "11.4" "18.6" "17.5" "14.9" "14.6" "18.3" "148.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8849479475208291816" "False" "High" "IsMasterProtein" "Q9H8Y5" "tRNA endonuclease ANKZF1 OS=Homo sapiens OX=9606 GN=ANKZF1 PE=1 SV=1" "0.003" "False" "2.769" "2" "1" "2" "1" "726" "80.9" "8.41" "2.04" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response" "other cell component" "other molecular function" "Pf00023, Pf18716, Pf18826" "55139" "ENSG00000163516" "ANKZF1" "hsa:55139; Q9H8Y5; Q9NVZ4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-579603406694116788" "False" "High" "IsMasterProtein" "Q9H0C5" "BTB/POZ domain-containing protein 1 OS=Homo sapiens OX=9606 GN=BTBD1 PE=1 SV=1" "0.003" "False" "2.767" "2" "1" "1" "1" "482" "52.7" "6.10" "1.88" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00651, Pf07707, Pf08005" "53339" "ENSG00000064726" "BTBD1" "A6NMI8; hsa:53339; Q9BX71; Q9H0C5; Q9NWN4" "15q25 copy number variation" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "3" "0" "0.800" "0.851" "0.702" "0.688" "0.782" "0.966" "0.531" "0.696" "1.560" "26.0" "20.8" "22.2" "18.3" "17.9" "20.4" "25.2" "13.8" "18.1" "40.6" "" "" "" "" "" "" "" "" "" "" "13.8" "11.6" "12.7" "8.4" "9.7" "11.3" "14.8" "7.6" "10.2" "40.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1616595542625436951" "False" "High" "IsMasterProtein" "Q96LR5" "Ubiquitin-conjugating enzyme E2 E2 OS=Homo sapiens OX=9606 GN=UBE2E2 PE=1 SV=1" "0.003" "False" "2.760" "4" "1" "1" "1" "201" "22.2" "7.71" "2.76" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf00179" "7325" "ENSG00000182247" "UBE2E2" "hsa:7325; Q96LR5" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.804" "0.882" "1.246" "1.129" "1.052" "1.128" "1.140" "1.180" "2.078" "46.7" "37.5" "41.2" "58.2" "52.7" "49.1" "52.6" "53.2" "55.1" "97.0" "" "" "" "" "" "" "" "" "" "" "24.7" "20.8" "23.6" "26.8" "28.5" "27.3" "31.0" "29.0" "30.9" "97.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5970229024696725622" "False" "High" "IsMasterProtein" "O96020" "G1/S-specific cyclin-E2 OS=Homo sapiens OX=9606 GN=CCNE2 PE=1 SV=1" "0.003" "False" "2.756" "2" "1" "1" "1" "404" "46.7" "7.83" "3.01" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00134, Pf02984" "9134" "ENSG00000175305" "CCNE2" "hsa:9134; O95439; O96020" "miRNA regulation of DNA damage response; Cell cycle; Parkinson's disease pathway; Retinoblastoma gene in cancer; PI3K-Akt signaling pathway; Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; NF1 copy number variation syndrome ; DNA damage response" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; Association of TriC/CCT with target proteins during biosynthesis; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); DNA Damage/Telomere Stress Induced Senescence; G0 and Early G1; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; p53-Dependent G1 DNA Damage Response" "22" "0" "1.104" "1.051" "1.073" "1.162" "1.070" "1.103" "0.992" "1.142" "1.217" "109.0" "120.3" "114.5" "116.9" "126.6" "116.6" "120.2" "108.1" "124.5" "132.7" "" "" "" "" "" "" "" "" "" "" "57.7" "66.7" "65.6" "53.8" "68.5" "64.8" "70.7" "59.0" "69.8" "132.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5711081481514943927" "False" "High" "IsMasterProtein" "P07858" "Cathepsin B OS=Homo sapiens OX=9606 GN=CTSB PE=1 SV=3" "0.003" "False" "2.755" "3" "1" "1" "1" "339" "37.8" "6.30" "2.26" "1" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00112, Pf08127" "1508" "ENSG00000164733; ENSG00000285132" "CTSB" "B3KQR5; B3KRR5; hsa:1508; P07858; Q503A6; Q96D87" "Ebola virus infection in host; 8p23.1 copy number variation syndrome" "Neutrophil degranulation; MHC class II antigen presentation; Collagen degradation; Assembly of collagen fibrils and other multimeric structures; Trafficking and processing of endosomal TLR" "7" "0" "1.008" "1.034" "0.927" "1.031" "0.978" "0.850" "1.106" "0.992" "0.661" "58.0" "58.4" "60.0" "53.8" "59.8" "56.7" "49.3" "64.2" "57.5" "38.4" "" "" "" "" "" "" "" "" "" "" "30.7" "32.4" "34.3" "24.8" "32.3" "31.5" "29.0" "35.0" "32.3" "38.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9153241618277291639" "False" "High" "IsMasterProtein" "Q9ULK4" "Mediator of RNA polymerase II transcription subunit 23 OS=Homo sapiens OX=9606 GN=MED23 PE=1 SV=2" "0.003" "False" "2.754" "1" "2" "2" "2" "1368" "156.4" "7.40" "4.18" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11573" "9439" "ENSG00000112282" "MED23" "B9TX55; hsa:9439; O95403; Q5JWT3; Q5JWT4; Q6P9H6; Q9H0J2; Q9NTT9; Q9NTU0; Q9ULK4; Q9Y5P7; Q9Y667" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "0.942" "0.856" "0.886" "0.807" "0.779" "0.893" "0.852" "0.775" "1.057" "132.4" "124.7" "113.3" "117.3" "106.9" "103.1" "118.3" "112.8" "102.6" "140.0" "" "" "" "" "" "" "" "" "" "" "70.1" "69.1" "64.9" "54.0" "57.8" "57.3" "69.6" "61.6" "57.6" "140.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3273487821867758056" "False" "High" "IsMasterProtein" "Q96DV4" "Large ribosomal subunit protein mL38 OS=Homo sapiens OX=9606 GN=MRPL38 PE=1 SV=2" "0.003" "False" "2.751" "3" "1" "1" "1" "380" "44.6" "7.53" "3.28" "1" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "" "Pf01161" "64978" "ENSG00000204316" "MRPL38" "B3KN96; hsa:64978; Q96DV4; Q96Q66; Q9P0B9" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.015" "1.062" "1.045" "0.969" "0.976" "0.887" "0.748" "0.843" "1.726" "176.0" "178.6" "187.0" "183.9" "170.6" "171.8" "156.1" "131.7" "148.3" "303.8" "" "" "" "" "" "" "" "" "" "" "93.2" "99.0" "107.1" "84.7" "92.3" "95.6" "91.9" "71.9" "83.2" "303.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5885254063310961994" "False" "High" "IsMasterProtein" "Q6NXT1" "Ankyrin repeat domain-containing protein 54 OS=Homo sapiens OX=9606 GN=ANKRD54 PE=1 SV=2" "0.003" "False" "2.747" "3" "1" "1" "1" "300" "32.5" "6.28" "2.60" "1" "transport;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00023, Pf12796" "129138" "ENSG00000100124" "ANKRD54" "hsa:129138; Q6NXT1; Q6ZSB1; Q9UGV1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6536357785872288465" "False" "High" "IsMasterProtein" "P48723" "Heat shock 70 kDa protein 13 OS=Homo sapiens OX=9606 GN=HSPA13 PE=1 SV=1" "0.003" "False" "2.741" "2" "1" "1" "1" "471" "51.9" "5.76" "2.58" "1" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00012" "6782" "ENSG00000155304" "HSPA13" "B2R616; hsa:6782; P48723; Q8NE40" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "1.008" "1.286" "1.230" "1.243" "1.054" "1.091" "1.260" "1.252" "0.959" "64.2" "64.7" "82.6" "79.0" "79.8" "67.7" "70.0" "80.9" "80.4" "61.6" "" "" "" "" "" "" "" "" "" "" "34.0" "35.9" "47.3" "36.4" "43.2" "37.6" "41.2" "44.2" "45.1" "61.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7721582400660787317" "False" "High" "IsMasterProtein" "Q6NVV1" "Putative ribosomal protein uL13-like OS=Homo sapiens OX=9606 GN=RPL13AP3 PE=5 SV=1" "0.003" "False" "2.740" "11" "1" "1" "1" "102" "12.1" "10.76" "2.31" "1" "protein metabolism;other metabolic processes" "translational apparatus;other cell component" "other molecular function" "" "" "" "RPL13AP3" "Q6NVV1" "" "" "0" "0" "0.998" "1.315" "1.479" "1.044" "1.331" "0.882" "1.122" "1.063" "1.060" "51.0" "50.9" "67.0" "75.4" "53.2" "67.9" "45.0" "57.2" "54.2" "54.1" "" "" "" "" "" "" "" "" "" "" "27.0" "28.2" "38.4" "34.7" "28.8" "37.7" "26.5" "31.2" "30.4" "54.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5405439584537602890" "False" "High" "IsMasterProtein" "Q9BX46" "RNA-binding protein 24 OS=Homo sapiens OX=9606 GN=RBM24 PE=1 SV=1" "0.003" "False" "2.739" "4" "1" "1" "1" "236" "24.8" "8.51" "2.45" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf00076" "221662" "ENSG00000112183" "RBM24" "E9PAY4; hsa:221662; Q6QDA4; Q8N9D3; Q96NI3; Q9BX46" "" "" "0" "0" "1.273" "1.354" "0.930" "1.208" "1.220" "1.181" "1.090" "1.059" "0.679" "84.5" "107.5" "114.4" "78.6" "102.0" "103.0" "99.8" "92.1" "89.5" "57.4" "" "" "" "" "" "" "" "" "" "" "44.7" "59.6" "65.5" "36.2" "55.2" "57.3" "58.7" "50.3" "50.2" "57.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6983483800967602038" "False" "High" "IsMasterProtein" "Q9NVM9" "Integrator complex subunit 13 OS=Homo sapiens OX=9606 GN=INTS13 PE=1 SV=2" "0.003" "False" "2.733" "1" "1" "1" "1" "706" "80.2" "6.70" "2.01" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf10221" "55726" "ENSG00000064102" "INTS13" "B4DNK1; hsa:55726; Q86WE2; Q96HM2; Q9BTX2; Q9NTB6; Q9NVM5; Q9NVM9" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "0.856" "0.824" "1.153" "0.956" "0.995" "0.847" "0.909" "1.210" "1.287" "65.0" "55.6" "53.6" "74.9" "62.1" "64.6" "55.1" "59.0" "78.6" "83.6" "" "" "" "" "" "" "" "" "" "" "34.4" "30.8" "30.7" "34.5" "33.6" "36.0" "32.4" "32.2" "44.1" "83.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3588052474242389854" "False" "High" "IsMasterProtein" "Q92766" "Ras-responsive element-binding protein 1 OS=Homo sapiens OX=9606 GN=RREB1 PE=1 SV=3" "0.003" "False" "2.732" "0" "1" "1" "1" "1687" "181.3" "6.98" "3.07" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13894, Pf13912" "6239" "ENSG00000124782" "RREB1" "A2RRF5; E2GM80; E2GM81; hsa:6239; O75567; O75568; Q5VYB2; Q6BEP5; Q6BEP6; Q6BEP8; Q86SU2; Q92766; Q9Y474" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2534211096191502147" "False" "High" "IsMasterProtein" "O00560" "Syntenin-1 OS=Homo sapiens OX=9606 GN=SDCBP PE=1 SV=1" "0.003" "False" "2.729" "5" "2" "2" "2" "298" "32.4" "7.53" "0.00" "2" "cell-cell signaling;cell organization and biogenesis;protein metabolism;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00595" "6386" "ENSG00000137575" "SDCBP" "B2R5Q7; B4DUH3; B7ZLN2; O00173; O00560; O43391; Q14CP2" "Ectoderm differentiation; Ectoderm differentiation; VEGFA-VEGFR2 signaling; 11p11.2 copy number variation syndrome" "Neutrophil degranulation; Ephrin signaling; Neurofascin interactions; Regulation of necroptotic cell death" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1227162241055397784" "False" "High" "IsMasterProtein" "Q9H0W8" "Nonsense-mediated mRNA decay factor SMG9 OS=Homo sapiens OX=9606 GN=SMG9 PE=1 SV=1" "0.003" "False" "2.727" "3" "1" "1" "1" "520" "57.6" "7.01" "1.67" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol" "other molecular function" "" "56006" "ENSG00000105771" "SMG9" "hsa:56006; O60429; Q9H0W8; Q9H9A9" "" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6157153298590242054" "False" "High" "IsMasterProtein" "Q8IZQ5" "Selenoprotein H OS=Homo sapiens OX=9606 GN=SELENOH PE=1 SV=2" "0.003" "False" "2.723" "9" "1" "1" "1" "122" "13.4" "9.74" "0.00" "1" "" "ER/Golgi" "" "Pf10262" "280636" "ENSG00000211450" "SELENOH" "hsa:280636; Q8IZQ5; Q8N672" "Selenium micronutrient network; Selenium metabolism and selenoproteins" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5029706333006790084" "False" "High" "IsMasterProtein" "Q5VT52" "Regulation of nuclear pre-mRNA domain-containing protein 2 OS=Homo sapiens OX=9606 GN=RPRD2 PE=1 SV=1" "0.003" "False" "2.721" "1" "1" "1" "1" "1461" "155.9" "7.42" "2.44" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf04818" "23248" "ENSG00000163125" "RPRD2" "A8K6N8; B3KPT1; B4E2Q6; hsa:23248; O75048; Q5VT51; Q5VT52; Q5VT53; Q6MZL4; Q86XD2; Q9P0D7" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5104969040472016970" "False" "High" "IsMasterProtein" "Q13576" "Ras GTPase-activating-like protein IQGAP2 OS=Homo sapiens OX=9606 GN=IQGAP2 PE=1 SV=4" "0.003" "False" "2.721" "1" "1" "1" "1" "1575" "180.5" "5.64" "2.25" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00307, Pf00612, Pf00616, Pf03836" "10788" "ENSG00000145703" "IQGAP2" "A8K4V1; B7Z8A4; hsa:10788; J3KR91; Q13576" "Ciliary landscape; G13 signaling pathway" "Neutrophil degranulation; RHO GTPases activate IQGAPs; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle" "7" "0" "1.061" "1.172" "1.061" "1.073" "1.135" "0.827" "0.764" "1.424" "2.984" "19.5" "20.6" "22.8" "20.6" "20.9" "22.1" "16.1" "14.9" "27.7" "58.1" "" "" "" "" "" "" "" "" "" "" "10.3" "11.4" "13.1" "9.5" "11.3" "12.3" "9.5" "8.1" "15.6" "58.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4234172936871541887" "False" "High" "IsMasterProtein" "Q9HA65" "TBC1 domain family member 17 OS=Homo sapiens OX=9606 GN=TBC1D17 PE=1 SV=3" "0.003" "False" "2.720" "1" "1" "1" "1" "648" "72.6" "5.21" "2.20" "1" "other metabolic processes;transport" "cytosol;other cytoplasmic organelle" "enzyme regulator activity" "Pf00566, Pf12068" "79735" "ENSG00000104946" "TBC1D17" "B4DT12; B9A6L8; F5H1W7; hsa:79735; Q9HA65" "" "TBC/RABGAPs" "1" "0" "1.181" "1.126" "1.193" "1.090" "0.956" "1.179" "1.156" "1.012" "1.604" "67.4" "79.6" "75.9" "80.4" "73.5" "64.4" "79.5" "77.9" "68.2" "108.1" "" "" "" "" "" "" "" "" "" "" "35.7" "44.1" "43.5" "37.0" "39.8" "35.8" "46.8" "42.5" "38.3" "108.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1838412941252019118" "False" "High" "IsMasterProtein" "Q9Y530" "ADP-ribose glycohydrolase OARD1 OS=Homo sapiens OX=9606 GN=OARD1 PE=1 SV=2" "0.004" "False" "2.718" "5" "1" "1" "1" "152" "17.0" "8.31" "1.65" "1" "protein metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf01661" "221443" "ENSG00000124596" "OARD1" "A6NEK4; A8K4H4; hsa:221443; Q96F23; Q9Y530" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1562013219529803649" "False" "High" "IsMasterProtein" "P15391" "B-lymphocyte antigen CD19 OS=Homo sapiens OX=9606 GN=CD19 PE=1 SV=6" "0.004" "False" "2.716" "2" "1" "1" "1" "556" "61.1" "4.98" "2.21" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "" "" "930" "ENSG00000177455" "CD19" "A0N0P9; F5H635; hsa:930; P15391; Q96S68; Q9BRD6" "B cell receptor signaling pathway; Complement system; PI3K-Akt signaling pathway; Leukocyte-intrinsic Hippo pathway functions; 16p11.2 distal deletion syndrome; Extrafollicular and follicular B cell activation by SARS-CoV-2; 11p11.2 copy number variation syndrome" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" "13" "0" "1.124" "1.322" "1.412" "1.244" "1.341" "0.857" "1.239" "0.948" "0.721" "32.7" "36.8" "43.2" "46.2" "40.7" "43.9" "28.0" "40.5" "31.0" "23.6" "" "" "" "" "" "" "" "" "" "" "17.3" "20.4" "24.8" "21.3" "22.0" "24.4" "16.5" "22.1" "17.4" "23.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "138932936592921501" "False" "High" "IsMasterProtein" "Q9ULJ3" "Zinc finger and BTB domain-containing protein 21 OS=Homo sapiens OX=9606 GN=ZBTB21 PE=1 SV=2" "0.004" "False" "2.714" "1" "1" "1" "1" "1066" "118.8" "8.29" "2.43" "1" "other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651, Pf18450" "49854" "ENSG00000173276" "ZBTB21" "hsa:49854; Q5R2W1; Q5R2W2; Q6P4R0; Q9ULJ3" "" "" "0" "0" "0.946" "1.062" "1.188" "1.182" "1.094" "1.148" "1.354" "1.137" "0.938" "107.4" "101.5" "114.1" "127.6" "127.0" "117.5" "123.2" "145.4" "122.1" "100.7" "" "" "" "" "" "" "" "" "" "" "56.8" "56.3" "65.3" "58.7" "68.7" "65.4" "72.5" "79.4" "68.5" "100.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2412952300113516382" "False" "High" "IsMasterProtein" "Cont_P28800" "Alpha-2-antiplasmin OS=Bos taurus OX=9913 GN=SERPINF2 PE=1 SV=2" "0.004" "True" "2.714" "2" "1" "1" "1" "492" "54.7" "5.72" "2.97" "1" "stress response;other biological processes" "non-structural extracellular" "enzyme regulator activity" "Pf00079" "282522" "ENSBIXG00000029361; ENSBTAG00000020859" "SERPINF2" "A0A4W2DRH6; bta:282522; P28800" "Complement and coagulation cascades; Blood clotting cascade" "Platelet degranulation ; Dissolution of Fibrin Clot" "4" "0" "1.059" "1.005" "1.196" "1.163" "1.071" "1.276" "1.125" "1.203" "0.699" "125.4" "132.8" "126.0" "150.0" "145.8" "134.3" "160.1" "141.1" "150.9" "87.7" "" "" "" "" "" "" "" "" "" "" "66.4" "73.6" "72.2" "69.1" "78.9" "74.7" "94.2" "77.0" "84.7" "87.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7557449725087676483" "False" "High" "IsMasterProtein" "Q3MIT2" "tRNA pseudouridine synthase Pus10 OS=Homo sapiens OX=9606 GN=PUS10 PE=1 SV=1" "0.004" "False" "2.709" "2" "1" "1" "1" "529" "60.2" "6.54" "1.60" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf21237, Pf21238" "150962" "ENSG00000162927" "PUS10" "hsa:150962; Q3MIT2; Q5JPJ5; Q96MI8" "" "" "0" "0" "1.010" "1.091" "1.133" "1.117" "1.121" "1.049" "1.089" "1.053" "1.633" "87.1" "87.9" "95.0" "98.7" "97.3" "97.7" "91.4" "94.8" "91.7" "142.2" "" "" "" "" "" "" "" "" "" "" "46.1" "48.8" "54.4" "45.4" "52.6" "54.3" "53.8" "51.8" "51.4" "142.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7714801153834532541" "False" "High" "IsMasterProtein" "O14733" "Dual specificity mitogen-activated protein kinase kinase 7 OS=Homo sapiens OX=9606 GN=MAP2K7 PE=1 SV=2" "0.004" "False" "2.704" "2" "1" "1" "1" "419" "47.5" "9.16" "2.72" "1" "other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5609" "ENSG00000076984" "MAP2K7" "B2R9S5; D6W659; hsa:5609; O14648; O14733; O14816; O60452; O60453; Q1PG43; Q8IY10" "MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Photodynamic therapy-induced AP-1 survival signaling; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; MAPK cascade; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Alzheimer's disease; GNAQ pathways in port-wine stain; ErbB signaling pathway; Toll-like receptor signaling pathway" "FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Uptake and function of anthrax toxins" "28" "0" "1.244" "0.849" "1.198" "1.156" "0.960" "1.031" "0.933" "0.871" "1.252" "93.8" "116.7" "79.7" "112.5" "108.5" "90.1" "96.7" "87.6" "81.7" "117.5" "" "" "" "" "" "" "" "" "" "" "49.7" "64.7" "45.6" "51.8" "58.7" "50.1" "56.9" "47.8" "45.8" "117.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7789640174005982269" "False" "High" "IsMasterProtein" "Q9Y5R2" "Matrix metalloproteinase-24 OS=Homo sapiens OX=9606 GN=MMP24 PE=1 SV=1" "0.004" "False" "2.704" "2" "1" "1" "1" "645" "73.2" "9.23" "2.07" "1" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00045, Pf00413, Pf01471, Pf11857" "10893" "ENSG00000125966" "MMP24" "B7ZBG8; hsa:10893; Q9H440; Q9Y5R2" "Matrix metalloproteinases; Chronic hyperglycemia impairment of neuron function" "Activation of Matrix Metalloproteinases" "3" "0" "0.930" "0.777" "0.935" "0.844" "0.975" "1.144" "0.875" "0.976" "0.928" "34.7" "32.3" "27.0" "32.4" "29.3" "33.8" "39.7" "30.4" "33.8" "32.2" "" "" "" "" "" "" "" "" "" "" "18.4" "17.9" "15.4" "14.9" "15.8" "18.8" "23.3" "16.6" "19.0" "32.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1176127761844367310" "False" "High" "IsMasterProtein" "Q9H2G2" "STE20-like serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=SLK PE=1 SV=1" "0.004" "False" "2.703" "1" "1" "1" "1" "1235" "142.6" "5.15" "2.86" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12474" "9748" "ENSG00000065613" "SLK" "D3DRA0; D3DRA1; hsa:9748; O00211; Q6P1Z4; Q86WU7; Q86WW1; Q92603; Q9H2G2; Q9NQL0; Q9NQL1" "TAR syndrome" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle" "4" "0" "0.953" "0.974" "0.922" "0.933" "0.914" "0.981" "0.916" "0.977" "1.476" "212.1" "202.2" "206.5" "195.5" "198.0" "193.8" "208.0" "194.2" "207.3" "313.1" "" "" "" "" "" "" "" "" "" "" "112.3" "112.1" "118.3" "90.0" "107.1" "107.8" "122.4" "106.0" "116.3" "313.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3307427478696066462" "False" "High" "IsMasterProtein" "Q96AJ9" "Vesicle transport through interaction with t-SNAREs homolog 1A OS=Homo sapiens OX=9606 GN=VTI1A PE=1 SV=2" "0.004" "False" "2.697" "4" "1" "1" "1" "217" "25.2" "6.40" "2.28" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05008, Pf12352" "143187" "ENSG00000151532" "VTI1A" "A2A307; B4E137; hsa:143187; Q5W0D7; Q96AJ9" "" "Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4400189645946568146" "False" "High" "IsMasterProtein" "O00488" "Zinc finger protein 593 OS=Homo sapiens OX=9606 GN=ZNF593 PE=1 SV=2" "0.004" "False" "2.696" "10" "1" "1" "1" "134" "15.2" "9.82" "0.00" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12171" "51042" "ENSG00000142684" "ZNF593" "B2R4S0; hsa:51042; O00488; Q5T2H7" "" "" "0" "0" "1.043" "1.085" "1.540" "1.279" "1.159" "1.516" "1.110" "1.261" "0.879" "22.3" "23.2" "24.2" "34.3" "28.5" "25.8" "33.8" "24.7" "28.1" "19.6" "" "" "" "" "" "" "" "" "" "" "11.8" "12.9" "13.8" "15.8" "15.4" "14.4" "19.9" "13.5" "15.8" "19.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5673730343044781282" "False" "High" "IsMasterProtein" "Q96HS1" "Serine/threonine-protein phosphatase PGAM5, mitochondrial OS=Homo sapiens OX=9606 GN=PGAM5 PE=1 SV=2" "0.004" "False" "2.696" "3" "1" "1" "1" "289" "32.0" "8.68" "2.79" "1" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "enzyme regulator activity;other molecular function" "Pf00300" "192111" "ENSG00000247077" "PGAM5" "A9LN06; C9IZY7; hsa:192111; Q96HS1; Q96JB0" "NRF2-ARE regulation" "" "1" "0" "1.074" "1.057" "1.073" "1.080" "1.306" "1.182" "1.026" "1.036" "1.040" "107.2" "115.1" "113.2" "115.0" "115.7" "139.9" "126.6" "110.0" "111.1" "111.4" "" "" "" "" "" "" "" "" "" "" "56.7" "63.8" "64.8" "53.0" "62.6" "77.8" "74.5" "60.0" "62.3" "111.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2561010377563702326" "False" "High" "IsMasterProtein" "Q8WX92" "Negative elongation factor B OS=Homo sapiens OX=9606 GN=NELFB PE=1 SV=1" "0.004" "False" "2.692" "2" "1" "1" "1" "580" "65.7" "6.13" "2.28" "1" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf06209" "25920" "ENSG00000188986" "NELFB" "A0A0X1KG71; A2BFA3; hsa:25920; Q8WX92; Q96EW5; Q9H9R4; Q9ULN8; Q9Y3W0" "Initiation of transcription and translation elongation at the HIV-1 LTR; 4p16.3 copy number variation; 5q35 copy number variation" "RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; TP53 Regulates Transcription of DNA Repair Genes; NTRK3 as a dependence receptor" "18" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4556599553515132582" "False" "High" "IsMasterProtein" "Q6UB28" "Methionine aminopeptidase 1D, mitochondrial OS=Homo sapiens OX=9606 GN=METAP1D PE=1 SV=1" "0.004" "False" "2.688" "5" "1" "1" "1" "335" "37.1" "6.84" "2.34" "1" "protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf00557" "254042" "ENSG00000172878; ENSG00000292097" "METAP1D" "hsa:254042; Q1WNX3; Q6UB28" "" "" "0" "0" "1.117" "1.568" "1.534" "1.207" "0.898" "1.586" "1.045" "1.117" "0.903" "30.7" "34.3" "48.1" "47.1" "37.1" "27.6" "48.7" "32.1" "34.3" "27.7" "" "" "" "" "" "" "" "" "" "" "16.3" "19.0" "27.6" "21.7" "20.1" "15.3" "28.7" "17.5" "19.2" "27.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1624211832406913783" "False" "High" "IsMasterProtein" "P15884" "Transcription factor 4 OS=Homo sapiens OX=9606 GN=TCF4 PE=1 SV=3" "0.004" "False" "2.671" "1" "1" "1" "1" "667" "71.3" "7.01" "2.75" "1" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "6925" "ENSG00000196628" "TCF4" "B3KT62; B3KUC0; B4DT37; B4DUG3; B7Z5M6; B7Z6Y1; G0LNT9; G0LNU0; G0LNU1; G0LNU2; G0LNU4; G0LNU5; G0LNU8; G0LNU9; G0LNV0; G0LNV1; G0LNV2; H3BPQ1; hsa:6925; P15884; Q08AP2; Q08AP3; Q15439; Q15440; Q15441" "Neural crest differentiation; Corticotropin-releasing hormone signaling pathway; Mesodermal commitment pathway; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Development of pulmonary dendritic cells and macrophage subsets; Rett syndrome; Gastrin signaling pathway; Neurogenesis regulation in the olfactory epithelium" "Myogenesis" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "376281410555249272" "False" "High" "IsMasterProtein" "O75592" "E3 ubiquitin-protein ligase MYCBP2 OS=Homo sapiens OX=9606 GN=MYCBP2 PE=1 SV=4" "0.004" "False" "2.666" "0" "2" "2" "2" "4678" "513.3" "7.02" "4.12" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00415, Pf03256, Pf08005, Pf13540" "23077" "ENSG00000005810" "MYCBP2" "A6NJC6; O75592; Q5JSX8; Q5VZN6; Q6PIB6; Q9UQ11; Q9Y6E4" "3q29 copy number variation syndrome" "" "1" "0" "0.985" "1.067" "1.176" "1.084" "0.914" "1.225" "0.942" "1.123" "1.692" "88.7" "87.4" "94.7" "104.3" "96.1" "81.1" "108.7" "83.5" "99.6" "150.1" "" "" "" "" "" "" "" "" "" "" "47.0" "48.5" "54.2" "48.0" "52.0" "45.1" "64.0" "45.6" "55.9" "150.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1078046361948541096" "False" "High" "IsMasterProtein" "Q6UWP2" "Dehydrogenase/reductase SDR family member 11 OS=Homo sapiens OX=9606 GN=DHRS11 PE=1 SV=1" "0.004" "False" "2.660" "4" "1" "1" "1" "260" "28.3" "6.64" "2.29" "1" "other metabolic processes" "non-structural extracellular" "other molecular function" "Pf00106" "79154" "ENSG00000275397; ENSG00000278535" "DHRS11" "A0A0U5BLD0; B2RDZ3; hsa:79154; Q6UWP2; Q9BUC7; Q9H674" "17q12 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1475037397769826540" "False" "High" "IsMasterProtein" "O75817" "Ribonuclease P protein subunit p20 OS=Homo sapiens OX=9606 GN=POP7 PE=1 SV=2" "0.004" "False" "2.659" "6" "1" "1" "1" "140" "15.6" "8.94" "3.12" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12328" "10248" "ENSG00000172336" "POP7" "A4D2E0; hsa:10248; O75817; Q9BV74" "" "tRNA processing in the nucleus" "1" "0" "0.896" "0.772" "0.901" "1.041" "0.975" "0.896" "0.787" "0.997" "0.691" "57.0" "51.1" "44.0" "51.4" "59.4" "55.6" "51.1" "44.9" "56.9" "39.4" "" "" "" "" "" "" "" "" "" "" "30.2" "28.3" "25.2" "23.7" "32.1" "30.9" "30.1" "24.5" "31.9" "39.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3774842769131475239" "False" "High" "IsMasterProtein" "Q9Y2R5" "Small ribosomal subunit protein uS17m OS=Homo sapiens OX=9606 GN=MRPS17 PE=1 SV=1" "0.004" "False" "2.658" "8" "1" "1" "1" "130" "14.5" "9.85" "2.34" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity" "Pf00366" "51373" "ENSG00000239789" "MRPS17" "hsa:51373; Q86X15; Q9Y2R5" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.327" "1.710" "1.452" "1.258" "1.226" "1.552" "1.139" "0.929" "2.523" "38.7" "51.3" "66.2" "56.2" "48.7" "47.4" "60.1" "44.1" "35.9" "97.6" "" "" "" "" "" "" "" "" "" "" "20.5" "28.5" "37.9" "25.9" "26.3" "26.4" "35.3" "24.0" "20.2" "97.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-572232975925861742" "False" "High" "IsMasterProtein" "P46779" "Large ribosomal subunit protein eL28 OS=Homo sapiens OX=9606 GN=RPL28 PE=1 SV=3" "0.004" "False" "2.649" "8" "1" "1" "1" "137" "15.7" "12.02" "0.00" "1" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01778" "6158" "ENSG00000108107" "RPL28" "B2R4A6; B4DEP9; C9JB50; E9PB24; G5E9L2; hsa:6158; P46779; Q6IAY0; Q96FX1; Q9BWQ0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis" "14" "0" "1.123" "1.108" "1.494" "1.227" "1.257" "1.115" "1.178" "0.932" "1.043" "46.4" "52.1" "51.4" "69.3" "56.9" "58.3" "51.7" "54.6" "43.2" "48.4" "" "" "" "" "" "" "" "" "" "" "24.5" "28.9" "29.4" "31.9" "30.8" "32.4" "30.4" "29.8" "24.2" "48.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2982009215915538431" "False" "High" "IsMasterProtein" "Q8TBA6" "Golgin subfamily A member 5 OS=Homo sapiens OX=9606 GN=GOLGA5 PE=1 SV=3" "0.004" "False" "2.637" "2" "1" "1" "1" "731" "83.0" "5.83" "2.18" "1" "cell organization and biogenesis;transport" "other membranes;ER/Golgi" "other molecular function" "Pf09787" "9950" "ENSG00000066455" "GOLGA5" "C9JRU1; hsa:9950; O95287; Q03962; Q2TS49; Q8TBA6; Q9UQQ7" "" "Intra-Golgi traffic" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8284852689861497980" "False" "High" "IsMasterProtein" "Q5VV52" "Zinc finger protein 691 OS=Homo sapiens OX=9606 GN=ZNF691 PE=1 SV=2" "0.004" "False" "2.633" "3" "1" "1" "1" "315" "35.8" "7.80" "2.27" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13465" "51058" "ENSG00000164011" "ZNF691" "A8MXP6; B4DJR7; hsa:51058; O95878; Q5VV52; Q9NWE8" "" "Generic Transcription Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8490030146092636123" "False" "High" "IsMasterProtein" "Q7Z422" "SUZ RNA-binding domain-containing OS=Homo sapiens OX=9606 GN=SZRD1 PE=1 SV=1" "0.004" "False" "2.620" "5" "1" "1" "1" "152" "17.0" "8.95" "3.73" "1" "" "" "" "Pf12752, Pf12901" "26099" "ENSG00000055070; ENSG00000291379" "SZRD1" "A8MXJ2; C9K0U0; hsa:26099; Q7Z422; Q7Z424; Q8IVM2; Q8TBV3; Q9Y403" "" "" "0" "0" "0.866" "0.952" "1.055" "0.882" "0.829" "0.865" "0.953" "0.873" "0.370" "281.8" "244.0" "268.3" "297.4" "248.5" "233.7" "243.7" "268.5" "246.0" "104.1" "" "" "" "" "" "" "" "" "" "" "149.2" "135.3" "153.7" "136.9" "134.5" "130.0" "143.4" "146.6" "138.0" "104.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9103143806185528671" "False" "High" "IsMasterProtein" "Q86UA1" "Pre-mRNA-processing factor 39 OS=Homo sapiens OX=9606 GN=PRPF39 PE=1 SV=3" "0.004" "False" "2.619" "3" "2" "3" "2" "669" "78.4" "5.40" "3.98" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "" "55015" "ENSG00000185246" "PRPF39" "hsa:55015; Q08AL1; Q08AL2; Q86UA1; Q9NUU5" "" "" "0" "0" "1.130" "1.223" "1.118" "1.288" "1.020" "1.276" "0.630" "0.840" "5.504" "40.3" "45.6" "49.3" "45.1" "51.9" "41.1" "51.5" "25.4" "33.9" "222.0" "" "" "" "" "" "" "" "" "" "" "21.4" "25.3" "28.3" "20.8" "28.1" "22.9" "30.3" "13.9" "19.0" "222.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6209519133895389976" "False" "High" "IsMasterProtein" "Q9P107" "GEM-interacting protein OS=Homo sapiens OX=9606 GN=GMIP PE=1 SV=2" "0.004" "False" "2.616" "1" "1" "1" "1" "970" "106.6" "5.72" "2.93" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf00620" "51291" "ENSG00000089639" "GMIP" "A0AVN9; B7ZLZ0; hsa:51291; Q9P107" "" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7269919126570467546" "False" "High" "IsMasterProtein" "Q16514" "Transcription initiation factor TFIID subunit 12 OS=Homo sapiens OX=9606 GN=TAF12 PE=1 SV=1" "0.004" "False" "2.616" "5" "1" "1" "1" "161" "17.9" "7.99" "2.31" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03847" "6883" "ENSG00000120656" "TAF12" "D3DPM5; hsa:6883; Q15775; Q16514; Q5T077" "Eukaryotic transcription initiation" "HATs acetylate histones; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4717651617297181896" "False" "High" "IsMasterProtein" "Q9UIC8" "Leucine carboxyl methyltransferase 1 OS=Homo sapiens OX=9606 GN=LCMT1 PE=1 SV=2" "0.004" "False" "2.614" "2" "1" "1" "1" "334" "38.4" "6.04" "2.66" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf04072" "51451" "ENSG00000205629" "LCMT1" "A6NL89; A8K770; hsa:51451; Q53FC5; Q96CI5; Q9H6I9; Q9NTG4; Q9UIC8; Q9Y378" "" "Cyclin A/B1/B2 associated events during G2/M transition" "1" "0" "1.002" "0.942" "1.057" "1.109" "0.977" "1.083" "1.181" "1.047" "0.598" "82.7" "82.9" "77.9" "87.4" "91.7" "80.8" "89.5" "97.6" "86.6" "49.4" "" "" "" "" "" "" "" "" "" "" "43.8" "46.0" "44.6" "40.2" "49.6" "44.9" "52.7" "53.3" "48.6" "49.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8745389805375581361" "False" "High" "IsMasterProtein" "P24539" "ATP synthase F(0) complex subunit B1, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PB PE=1 SV=2" "0.004" "False" "2.610" "3" "1" "1" "1" "256" "28.9" "9.36" "2.68" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf05405" "515" "ENSG00000116459" "ATP5PB" "hsa:515; P24539; Q9BQ68; Q9BRU8" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "Cristae formation; Formation of ATP by chemiosmotic coupling" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9138201911436176215" "False" "High" "IsMasterProtein" "Q13952" "Nuclear transcription factor Y subunit gamma OS=Homo sapiens OX=9606 GN=NFYC PE=1 SV=3" "0.004" "False" "2.609" "2" "1" "1" "1" "458" "50.3" "6.10" "3.37" "1" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "4802" "ENSG00000066136" "NFYC" "B4DUS6; B4DW63; D3DPV9; F8VWM3; hsa:4802; Q13952; Q59GY4; Q5T6K8; Q5T6K9; Q5T6L1; Q5TZR6; Q92869; Q9HBX1; Q9NXB5; Q9UM67; Q9UML0; Q9UMT7" "" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum stress; ATF6 (ATF6-alpha) activates chaperone genes" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7436482478148807515" "False" "High" "IsMasterProtein" "Q86TB9" "Protein PAT1 homolog 1 OS=Homo sapiens OX=9606 GN=PATL1 PE=1 SV=2" "0.004" "False" "2.605" "1" "1" "3" "1" "770" "86.8" "6.67" "8.53" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf09770" "219988" "ENSG00000166889" "PATL1" "B3KXT9; hsa:219988; Q2TA86; Q6P166; Q86TB9; Q8N9M6; Q8NI63" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "0.911" "0.945" "1.059" "0.834" "0.900" "1.221" "1.164" "1.103" "1.706" "166.8" "151.9" "157.6" "176.6" "139.0" "150.1" "203.6" "194.1" "184.0" "284.5" "" "" "" "" "" "" "" "" "" "" "88.3" "84.2" "90.3" "81.3" "75.2" "83.5" "119.8" "106.0" "103.2" "284.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8802052166726839277" "False" "High" "IsMasterProtein" "O75884" "Serine hydrolase RBBP9 OS=Homo sapiens OX=9606 GN=RBBP9 PE=1 SV=2" "0.004" "False" "2.592" "4" "1" "1" "1" "186" "21.0" "6.20" "2.86" "1" "developmental processes;other biological processes" "nucleus" "other molecular function" "Pf06821" "10741" "ENSG00000089050" "RBBP9" "D3DW31; hsa:10741; O75884; Q5JPH9; Q9H1D8" "" "" "0" "0" "0.943" "0.819" "1.076" "1.002" "0.978" "1.024" "0.992" "1.088" "3.038" "89.1" "84.0" "73.0" "95.8" "89.3" "87.2" "91.2" "88.4" "96.9" "270.7" "" "" "" "" "" "" "" "" "" "" "47.2" "46.6" "41.8" "44.1" "48.3" "48.5" "53.7" "48.2" "54.4" "270.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8114162095880212588" "False" "High" "IsMasterProtein" "Q9H3S7" "Tyrosine-protein phosphatase non-receptor type 23 OS=Homo sapiens OX=9606 GN=PTPN23 PE=1 SV=1" "0.004" "False" "2.590" "0" "1" "1" "1" "1636" "178.9" "6.92" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00102, Pf03097, Pf13949" "25930" "ENSG00000076201" "PTPN23" "A8K0D7; hsa:25930; Q7KZF8; Q8N6Z5; Q9BSR5; Q9H3S7; Q9P257; Q9UG03; Q9UMZ4" "" "Interleukin-37 signaling" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7740288424381142174" "False" "High" "IsMasterProtein" "O43181" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS4 PE=1 SV=1" "0.004" "False" "2.587" "5" "1" "2" "1" "175" "20.1" "10.30" "4.37" "1" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;mitochondrion" "transporter activity" "Pf04800" "4724" "ENSG00000164258" "NDUFS4" "hsa:4724; O43181; Q9BS69" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "0.870" "0.850" "1.053" "1.068" "1.079" "0.928" "1.076" "1.085" "0.341" "84.6" "73.6" "71.9" "89.1" "90.4" "91.3" "78.5" "91.0" "91.8" "28.9" "" "" "" "" "" "" "" "" "" "" "44.8" "40.8" "41.2" "41.0" "48.9" "50.8" "46.2" "49.7" "51.5" "28.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1632540778200031519" "False" "High" "IsMasterProtein" "Q9BVA0" "Katanin p80 WD40 repeat-containing subunit B1 OS=Homo sapiens OX=9606 GN=KATNB1 PE=1 SV=1" "0.004" "False" "2.584" "2" "1" "1" "1" "655" "72.3" "7.56" "2.16" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf13925" "10300" "ENSG00000140854" "KATNB1" "A6NCG6; hsa:10300; O60620; Q9BVA0" "Genes related to primary cilium development (based on CRISPR)" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6338677437993936073" "False" "High" "IsMasterProtein" "P30305" "M-phase inducer phosphatase 2 OS=Homo sapiens OX=9606 GN=CDC25B PE=1 SV=2" "0.004" "False" "2.582" "2" "1" "1" "1" "580" "64.9" "6.40" "1.96" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00581, Pf06617" "994" "ENSG00000101224" "CDC25B" "D3DVY1; D3DVY2; D3DVY3; D3DVY4; hsa:994; O43551; P30305; Q13971; Q5JX77; Q6RSS1; Q9BRA6" "Cell cycle; Integrated cancer pathway; Androgen receptor network in prostate cancer; Retinoblastoma gene in cancer; MAPK signaling pathway" "Cyclin A/B1/B2 associated events during G2/M transition; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Cyclin A:Cdk2-associated events at S phase entry" "8" "0" "0.998" "0.913" "1.367" "1.230" "0.988" "1.112" "0.980" "0.981" "0.739" "38.7" "38.7" "35.4" "52.9" "47.6" "38.3" "43.1" "38.0" "38.0" "28.6" "" "" "" "" "" "" "" "" "" "" "20.5" "21.4" "20.3" "24.4" "25.8" "21.3" "25.3" "20.7" "21.3" "28.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "485577591804044204" "False" "High" "IsMasterProtein" "Q96Q45" "Transmembrane protein 237 OS=Homo sapiens OX=9606 GN=TMEM237 PE=1 SV=2" "0.004" "False" "2.577" "2" "1" "2" "1" "408" "45.5" "6.47" "4.62" "1" "cell organization and biogenesis;other biological processes" "other cell component" "" "Pf15383" "65062" "ENSG00000155755" "TMEM237" "B4E1R8; B4E2R8; E9PAR8; E9PBF8; E9PG24; E9PGX0; hsa:65062; Q53TS9; Q53TT2; Q7Z3B6; Q8IZ18; Q8NBF8; Q96CY1; Q96Q45" "Joubert syndrome; Ciliopathies" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-104196132274101736" "False" "High" "IsMasterProtein" "Q9GZT4" "Serine racemase OS=Homo sapiens OX=9606 GN=SRR PE=1 SV=1" "0.004" "False" "2.577" "3" "1" "1" "1" "340" "36.5" "6.54" "2.26" "1" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00291" "63826" "ENSG00000167720" "SRR" "D3DTI5; hsa:63826; Q6IA55; Q9GZT4" "Neuroinflammation and glutamatergic signaling" "Serine biosynthesis" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2326437507521645462" "False" "High" "IsMasterProtein" "Q9P2W1" "Homologous-pairing protein 2 homolog OS=Homo sapiens OX=9606 GN=PSMC3IP PE=1 SV=1" "0.004" "False" "2.575" "4" "1" "1" "1" "217" "24.9" "7.81" "2.26" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf07106, Pf18517" "29893" "ENSG00000131470" "PSMC3IP" "C5ILB7; hsa:29893; Q14458; Q8WXG2; Q96HA2; Q9P2W1" "Androgen receptor signaling pathway; Primary ovarian insufficiency" "Meiotic recombination" "3" "0" "0.796" "0.903" "0.904" "1.001" "0.835" "0.831" "0.723" "0.855" "3.043" "45.8" "36.4" "41.3" "41.4" "45.8" "38.2" "38.0" "33.1" "39.1" "139.2" "" "" "" "" "" "" "" "" "" "" "24.2" "20.2" "23.7" "19.1" "24.8" "21.3" "22.4" "18.0" "22.0" "139.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4344816618369671433" "False" "High" "IsMasterProtein" "Q16537" "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform OS=Homo sapiens OX=9606 GN=PPP2R5E PE=1 SV=1" "0.004" "False" "2.574" "2" "1" "1" "1" "467" "54.7" "6.95" "2.77" "1" "signal transduction" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01603" "5529" "ENSG00000154001" "PPP2R5E" "A4FU37; B7ZAW5; B7ZKK8; B7ZKK9; hsa:5529; J3KQN6; Q16537; Q52LW4" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; DNA damage response (only ATM dependent)" "Resolution of Sister Chromatid Cohesion; CTLA4 inhibitory signaling; Separation of Sister Chromatids; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Negative regulation of MAPK pathway; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Platelet sensitization by LDL" "28" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4707319533501773453" "False" "High" "IsMasterProtein" "O95260" "Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=2" "0.004" "False" "2.574" "2" "1" "1" "1" "518" "59.1" "7.93" "2.96" "1" "protein metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf04376, Pf04377" "11101" "ENSG00000107669" "ATE1" "hsa:11101; O95260; O95261; Q5SQQ3; Q8WW04" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6587954621125457531" "False" "High" "IsMasterProtein" "Q9NVH6" "Trimethyllysine dioxygenase, mitochondrial OS=Homo sapiens OX=9606 GN=TMLHE PE=1 SV=1" "0.004" "False" "2.572" "2" "1" "1" "1" "421" "49.5" "7.72" "3.06" "1" "other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf02668, Pf06155" "55217" "ENSG00000185973" "TMLHE" "A8K6M9; B4E3R3; hsa:55217; Q5TZB5; Q6IA90; Q8TBT0; Q9NVH6" "" "Carnitine synthesis" "1" "0" "0.955" "0.941" "0.983" "1.068" "1.079" "1.251" "1.085" "0.964" "0.564" "143.4" "137.0" "134.9" "140.9" "153.2" "154.8" "179.4" "155.6" "138.2" "80.9" "" "" "" "" "" "" "" "" "" "" "75.9" "75.9" "77.3" "64.9" "82.9" "86.1" "105.6" "84.9" "77.5" "80.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "255349237203839233" "False" "High" "IsMasterProtein" "Q9Y2Y1" "DNA-directed RNA polymerase III subunit RPC10 OS=Homo sapiens OX=9606 GN=POLR3K PE=1 SV=3" "0.004" "False" "2.571" "10" "1" "1" "1" "108" "12.3" "7.83" "2.07" "1" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01096, Pf02150" "51728" "ENSG00000161980" "POLR3K" "hsa:51728; Q1W6H4; Q96S35; Q9Y2Y1" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "10" "0" "0.858" "1.149" "0.849" "0.757" "0.908" "1.099" "1.126" "1.060" "1.013" "57.6" "49.4" "66.2" "48.9" "43.6" "52.3" "63.3" "64.9" "61.1" "58.3" "" "" "" "" "" "" "" "" "" "" "30.5" "27.4" "37.9" "22.5" "23.6" "29.1" "37.2" "35.4" "34.3" "58.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9052184028571704461" "False" "High" "IsMasterProtein" "O75865" "Trafficking protein particle complex subunit 6A OS=Homo sapiens OX=9606 GN=TRAPPC6A PE=1 SV=2" "0.004" "False" "2.568" "5" "1" "1" "1" "159" "17.6" "5.26" "3.12" "1" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "" "Pf04051" "79090" "ENSG00000007255" "TRAPPC6A" "hsa:79090; K7ERB1; K7ERQ4; O75865; Q9BQ45; Q9P092" "" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7451398436155471702" "False" "High" "IsMasterProtein" "Q9BRZ2" "E3 ubiquitin-protein ligase TRIM56 OS=Homo sapiens OX=9606 GN=TRIM56 PE=1 SV=3" "0.004" "False" "2.567" "2" "1" "1" "1" "755" "81.4" "7.74" "0.00" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00643, Pf13445" "81844" "ENSG00000169871" "TRIM56" "hsa:81844; Q6PJS5; Q86VT6; Q8N2H8; Q8NAC0; Q9BRZ2; Q9H031" "" "Regulation of innate immune responses to cytosolic DNA" "1" "0" "1.532" "1.507" "1.249" "1.004" "1.127" "1.182" "1.049" "0.977" "0.963" "30.9" "47.4" "46.6" "38.7" "31.1" "34.9" "36.6" "32.4" "30.2" "29.8" "" "" "" "" "" "" "" "" "" "" "16.4" "26.3" "26.7" "17.8" "16.8" "19.4" "21.5" "17.7" "17.0" "29.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1870443060398404245" "False" "High" "IsMasterProtein" "Q9H0N5" "Pterin-4-alpha-carbinolamine dehydratase 2 OS=Homo sapiens OX=9606 GN=PCBD2 PE=1 SV=4" "0.004" "False" "2.566" "5" "1" "1" "1" "130" "14.4" "9.11" "3.14" "1" "other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01329" "84105" "ENSG00000132570" "PCBD2" "hsa:84105; Q8TD40; Q9H0N5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1339372435308816495" "False" "High" "IsMasterProtein" "Q8IWT0" "Protein archease OS=Homo sapiens OX=9606 GN=ZBTB8OS PE=1 SV=2" "0.004" "False" "2.551" "5" "1" "1" "1" "167" "19.5" "4.49" "2.44" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf01951" "339487" "ENSG00000176261" "ZBTB8OS" "hsa:339487; Q5TGK5; Q6PDA1; Q8IWS9; Q8IWT0; Q8NEV6; Q8NEV7" "" "tRNA processing in the nucleus" "1" "0" "0.856" "0.926" "0.898" "0.917" "0.979" "0.857" "0.857" "0.893" "0.617" "177.7" "152.2" "164.5" "159.5" "163.0" "174.0" "152.3" "152.3" "158.7" "109.7" "" "" "" "" "" "" "" "" "" "" "94.1" "84.4" "94.2" "73.5" "88.2" "96.8" "89.6" "83.2" "89.0" "109.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5454865549219062540" "False" "High" "IsMasterProtein" "P14859" "POU domain, class 2, transcription factor 1 OS=Homo sapiens OX=9606 GN=POU2F1 PE=1 SV=2" "0.004" "False" "2.548" "1" "1" "1" "1" "743" "76.4" "6.81" "2.38" "1" "other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf00157, Pf19536" "5451" "ENSG00000143190" "POU2F1" "B1AL91; B1AL93; B4E029; hsa:5451; J3KP77; P14859; Q5TBT7; Q6PK46; Q8NEU9; Q9BPV1" "Integrated cancer pathway" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interleukin-4 and Interleukin-13 signaling" "6" "0" "0.932" "0.970" "1.046" "1.000" "0.991" "0.984" "0.883" "0.916" "1.609" "238.0" "221.9" "231.0" "248.9" "238.1" "236.0" "234.2" "210.2" "218.1" "382.9" "" "" "" "" "" "" "" "" "" "" "126.0" "123.0" "132.3" "114.6" "128.8" "131.3" "137.8" "114.7" "122.3" "382.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5357467251583528977" "False" "High" "IsMasterProtein" "Q49AR2" "UPF0489 protein C5orf22 OS=Homo sapiens OX=9606 GN=C5orf22 PE=1 SV=2" "0.004" "False" "2.547" "3" "1" "1" "1" "442" "49.9" "4.78" "2.42" "1" "" "" "" "Pf12640" "55322" "ENSG00000082213" "C5orf22" "hsa:55322; Q49AR2; Q8ND28; Q8WU61; Q9NUR1" "" "" "0" "0" "0.995" "0.911" "0.877" "0.987" "1.051" "0.942" "0.912" "0.946" "1.098" "72.0" "71.7" "65.6" "63.2" "71.1" "75.7" "67.9" "65.7" "68.1" "79.1" "" "" "" "" "" "" "" "" "" "" "38.1" "39.7" "37.6" "29.1" "38.5" "42.1" "40.0" "35.9" "38.2" "79.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3560652470776637886" "False" "High" "IsMasterProtein" "O43567" "E3 ubiquitin-protein ligase RNF13 OS=Homo sapiens OX=9606 GN=RNF13 PE=1 SV=1" "0.004" "False" "2.544" "2" "1" "1" "1" "381" "42.8" "4.98" "2.80" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02225, Pf13639" "11342" "ENSG00000082996" "RNF13" "A6NC87; B3KR12; hsa:11342; O43567; Q05D66; Q6IBJ9" "" "" "0" "0" "0.931" "1.103" "0.923" "1.040" "0.987" "0.931" "1.069" "1.102" "0.573" "124.4" "115.9" "137.2" "114.8" "129.4" "122.9" "115.8" "133.0" "137.1" "71.3" "" "" "" "" "" "" "" "" "" "" "65.9" "64.2" "78.6" "52.9" "70.0" "68.3" "68.2" "72.6" "76.9" "71.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4212925493234983848" "False" "High" "IsMasterProtein" "Q14289" "Protein-tyrosine kinase 2-beta OS=Homo sapiens OX=9606 GN=PTK2B PE=1 SV=2" "0.004" "False" "2.542" "1" "1" "1" "1" "1009" "115.8" "6.25" "2.51" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "transporter activity;kinase activity;other molecular function" "Pf00373, Pf03623, Pf07714, Pf18038, Pf21477" "2185" "ENSG00000120899" "PTK2B" "D3DST0; hsa:2185; Q13475; Q14289; Q14290; Q16709; Q6PID4" "IL-7 signaling pathway; Androgen receptor network in prostate cancer; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Hepatocyte growth factor receptor signaling; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; EGF/EGFR signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; IL-2 signaling pathway; CCL18 signaling pathway; NPHP1 deletion syndrome; 8q11.23 (RB1CC1) copy number variation; HDAC6 interactions in the central nervous system; T-cell receptor signaling pathway" "RHOU GTPase cycle; Interleukin-2 signaling; Signal regulatory protein family interactions; VEGFA-VEGFR2 Pathway" "21" "0" "0.799" "0.598" "1.034" "0.983" "0.817" "0.665" "0.212" "0.900" "14.200" "19.6" "15.6" "11.7" "20.2" "19.2" "16.0" "13.0" "4.1" "17.6" "277.7" "" "" "" "" "" "" "" "" "" "" "10.4" "8.7" "6.7" "9.3" "10.4" "8.9" "7.7" "2.3" "9.9" "277.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4078172975795956139" "False" "High" "IsMasterProtein" "Q7Z6V5" "tRNA-specific adenosine deaminase 2 OS=Homo sapiens OX=9606 GN=ADAT2 PE=1 SV=1" "0.004" "False" "2.542" "4" "1" "1" "1" "191" "21.0" "6.74" "2.41" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf14437" "134637" "ENSG00000189007" "ADAT2" "A6NL12; B3KWY3; hsa:134637; Q7Z327; Q7Z6V5; Q8IY39" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.000" "0.878" "0.864" "0.991" "0.933" "0.893" "0.888" "0.919" "0.553" "109.6" "109.7" "96.2" "94.8" "108.6" "102.3" "97.9" "97.3" "100.7" "60.7" "" "" "" "" "" "" "" "" "" "" "58.1" "60.8" "55.1" "43.6" "58.8" "56.9" "57.6" "53.1" "56.5" "60.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3230263422708412736" "False" "High" "IsMasterProtein" "Q6UWP8" "Suprabasin OS=Homo sapiens OX=9606 GN=SBSN PE=1 SV=2" "0.004" "False" "2.537" "9" "1" "1" "1" "590" "60.5" "7.01" "0.00" "1" "" "" "" "Pf21009" "374897" "ENSG00000189001" "SBSN" "A8K5J0; E9PBV3; hsa:374897; Q6UWP8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2026118880241708351" "False" "High" "IsMasterProtein" "A5PLN9" "Trafficking protein particle complex subunit 13 OS=Homo sapiens OX=9606 GN=TRAPPC13 PE=1 SV=2" "0.004" "False" "2.529" "2" "1" "1" "1" "417" "46.5" "5.60" "1.78" "1" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf06159" "80006" "ENSG00000113597" "TRAPPC13" "A5PLN9; hsa:80006; Q17RZ9; Q49A23; Q4JHG0; Q6MZG4; Q8TCM2; Q9H8I3" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "1.052" "1.114" "1.339" "1.249" "1.147" "1.086" "0.869" "0.908" "3.527" "48.0" "50.5" "53.4" "64.2" "59.9" "55.0" "52.1" "41.7" "43.6" "169.2" "" "" "" "" "" "" "" "" "" "" "25.4" "28.0" "30.6" "29.6" "32.4" "30.6" "30.7" "22.7" "24.4" "169.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3796638279955905475" "False" "High" "IsMasterProtein" "Q9NZ32" "Actin-related protein 10 OS=Homo sapiens OX=9606 GN=ACTR10 PE=1 SV=1" "0.004" "False" "2.523" "2" "1" "1" "1" "417" "46.3" "7.37" "3.01" "1" "transport" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "" "Pf00022" "55860" "ENSG00000131966" "ACTR10" "hsa:55860; Q9H9Y5; Q9NWY2; Q9NZ32" "" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Neutrophil degranulation" "5" "0" "0.985" "1.097" "0.897" "0.891" "1.012" "1.055" "1.170" "1.061" "0.689" "209.5" "206.3" "229.8" "187.9" "186.6" "212.0" "221.1" "245.2" "222.3" "144.3" "" "" "" "" "" "" "" "" "" "" "110.9" "114.4" "131.6" "86.5" "101.0" "117.9" "130.1" "133.8" "124.7" "144.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1601999827614054718" "False" "High" "IsMasterProtein" "O95067" "G2/mitotic-specific cyclin-B2 OS=Homo sapiens OX=9606 GN=CCNB2 PE=1 SV=1" "0.004" "False" "2.523" "3" "1" "1" "1" "398" "45.3" "8.90" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf00134, Pf02984" "9133" "ENSG00000157456" "CCNB2" "B3KM93; hsa:9133; O95067; Q6FI99" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; TGF-beta signaling pathway; IL-18 signaling pathway; DNA damage response" "Resolution of Sister Chromatid Cohesion; Initiation of Nuclear Envelope (NE) Reformation; The role of GTSE1 in G2/M progression after G2 checkpoint; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Cyclin A/B1/B2 associated events during G2/M transition; Golgi Cisternae Pericentriolar Stack Reorganization; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint" "17" "0" "1.173" "1.217" "1.259" "1.057" "1.169" "1.243" "1.115" "1.199" "0.844" "48.4" "56.7" "58.9" "60.9" "51.1" "56.5" "60.1" "53.9" "58.0" "40.8" "" "" "" "" "" "" "" "" "" "" "25.6" "31.4" "33.7" "28.0" "27.7" "31.4" "35.4" "29.4" "32.5" "40.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "394232053154577892" "False" "High" "IsMasterProtein" "Q92530" "Proteasome inhibitor PI31 subunit OS=Homo sapiens OX=9606 GN=PSMF1 PE=1 SV=2" "0.004" "False" "2.522" "3" "1" "2" "1" "271" "29.8" "5.74" "2.18" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf08577, Pf11566" "9491" "ENSG00000125818" "PSMF1" "A0AVQ9; D3DVW3; hsa:9491; Q92530; Q9H4I1" "" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "59" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "282539810863181563" "False" "High" "IsMasterProtein" "Q9UL40" "Zinc finger protein 346 OS=Homo sapiens OX=9606 GN=ZNF346 PE=1 SV=1" "0.004" "False" "2.522" "3" "1" "1" "1" "294" "32.9" "9.09" "2.19" "1" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12874" "23567" "ENSG00000113761" "ZNF346" "B7Z367; hsa:23567; Q68CV9; Q6ZMW1; Q9UL40" "5q35 copy number variation" "" "1" "0" "1.004" "0.946" "0.981" "1.062" "1.235" "0.820" "0.941" "0.925" "0.803" "45.4" "45.6" "43.0" "44.6" "48.2" "56.1" "37.3" "42.8" "42.0" "36.5" "" "" "" "" "" "" "" "" "" "" "24.1" "25.3" "24.6" "20.5" "26.1" "31.2" "21.9" "23.3" "23.6" "36.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4293732190144876547" "False" "High" "IsMasterProtein" "P13498" "Cytochrome b-245 light chain OS=Homo sapiens OX=9606 GN=CYBA PE=1 SV=3" "0.004" "False" "2.521" "5" "1" "1" "1" "195" "21.0" "9.54" "2.11" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05038" "1535" "ENSG00000051523" "CYBA" "hsa:1535; P13498; Q14090; Q9BR72" "TNF-alpha signaling pathway; Microglia pathogen phagocytosis pathway; Urotensin-II-mediated signaling pathway; Genetic causes of porto-sinusoidal vascular disease" "Neutrophil degranulation; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Detoxification of Reactive Oxygen Species; VEGFA-VEGFR2 Pathway; WNT5:FZD7-mediated leishmania damping; ROS and RNS production in phagocytes; Cross-presentation of particulate exogenous antigens (phagosomes); RHO GTPases Activate NADPH Oxidases" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8170154363279556539" "False" "High" "IsMasterProtein" "Q6P1R3" "Myb/SANT-like DNA-binding domain-containing protein 2 OS=Homo sapiens OX=9606 GN=MSANTD2 PE=1 SV=1" "0.004" "False" "2.519" "2" "1" "1" "1" "559" "61.3" "6.19" "3.12" "1" "" "" "" "Pf13837" "79684" "ENSG00000120458" "MSANTD2" "B3KRY6; hsa:79684; Q6P1R3; Q9H042; Q9H5K8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1655818240381757095" "False" "High" "IsMasterProtein" "Q9NSY1" "BMP-2-inducible protein kinase OS=Homo sapiens OX=9606 GN=BMP2K PE=1 SV=2" "0.004" "False" "2.519" "1" "1" "1" "1" "1161" "129.1" "6.51" "2.59" "1" "other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf15282" "55589" "ENSG00000138756" "BMP2K" "hsa:55589; O94791; Q4W5H2; Q8IYF2; Q8N2G7; Q8NHG9; Q9NSY1; Q9NTG8" "" "" "0" "0" "0.828" "0.707" "0.680" "0.938" "0.833" "0.838" "0.836" "1.116" "0.828" "87.4" "72.3" "61.8" "59.4" "81.9" "72.8" "73.2" "73.0" "97.5" "72.3" "" "" "" "" "" "" "" "" "" "" "46.3" "40.1" "35.4" "27.4" "44.3" "40.5" "43.1" "39.9" "54.7" "72.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1233301175711817625" "False" "High" "IsMasterProtein" "P21926" "CD9 antigen OS=Homo sapiens OX=9606 GN=CD9 PE=1 SV=4" "0.004" "False" "2.519" "3" "1" "1" "1" "228" "25.4" "7.15" "3.15" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding" "Pf00335" "928" "ENSG00000010278" "CD9" "D3DUQ9; hsa:928; P21926; Q5J7W6; Q96ES4" "Vitamin D receptor pathway" "Platelet degranulation ; Uptake and function of diphtheria toxin; Acrosome Reaction and Sperm:Oocyte Membrane Binding" "4" "0" "1.030" "1.110" "0.890" "1.004" "1.205" "0.954" "0.998" "0.923" "0.361" "442.3" "455.4" "490.8" "393.6" "444.0" "533.1" "421.8" "441.4" "408.0" "159.6" "" "" "" "" "" "" "" "" "" "" "234.2" "252.5" "281.1" "181.3" "240.2" "296.5" "248.2" "240.9" "228.9" "159.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2564730176707544032" "False" "High" "IsMasterProtein" "O95479" "GDH/6PGL endoplasmic bifunctional protein OS=Homo sapiens OX=9606 GN=H6PD PE=1 SV=2" "0.004" "False" "2.518" "2" "1" "1" "1" "791" "88.8" "7.30" "2.03" "1" "other metabolic processes;other biological processes" "ER/Golgi" "other molecular function" "Pf00479, Pf01182, Pf02781" "9563" "ENSG00000049239" "H6PD" "hsa:9563; O95479; Q4TT33; Q66I35; Q68DT3; R4GMU1" "Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism" "" "1" "0" "0.924" "0.851" "0.991" "0.877" "0.948" "1.007" "0.749" "0.703" "0.954" "43.2" "39.9" "36.8" "42.8" "37.9" "41.0" "43.5" "32.3" "30.4" "41.2" "" "" "" "" "" "" "" "" "" "" "22.9" "22.1" "21.1" "19.7" "20.5" "22.8" "25.6" "17.7" "17.0" "41.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7903736519056340786" "False" "High" "IsMasterProtein" "P53985" "Monocarboxylate transporter 1 OS=Homo sapiens OX=9606 GN=SLC16A1 PE=1 SV=3" "0.004" "False" "2.515" "2" "1" "1" "1" "500" "53.9" "8.66" "3.18" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "transporter activity;other molecular function" "" "6566" "ENSG00000155380; ENSG00000281917" "SLC16A1" "hsa:6566; P53985; Q49A45; Q5T8R6; Q9NSJ9" "Photodynamic therapy-induced HIF-1 survival signaling; Fragile X syndrome; Glucose metabolism in triple-negative breast cancer cells" "Pyruvate metabolism; Aspirin ADME; Basigin interactions; Proton-coupled monocarboxylate transport; Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)" "8" "0" "0.974" "1.040" "0.891" "0.850" "0.904" "0.840" "0.711" "0.793" "0.222" "210.8" "205.2" "219.1" "187.9" "179.2" "190.5" "177.0" "149.8" "167.2" "46.9" "" "" "" "" "" "" "" "" "" "" "111.6" "113.8" "125.5" "86.5" "96.9" "106.0" "104.2" "81.8" "93.8" "46.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8401926335581845192" "False" "High" "IsMasterProtein" "Q96BU1" "S100P-binding protein OS=Homo sapiens OX=9606 GN=S100PBP PE=1 SV=1" "0.004" "False" "2.509" "2" "1" "1" "1" "408" "45.6" "5.17" "0.00" "1" "" "cytosol;nucleus" "other molecular function" "Pf15427" "64766" "ENSG00000116497" "S100PBP" "B3KR04; D3DPQ5; hsa:64766; Q5HYH3; Q96BU1; Q9H997" "" "" "0" "0" "1.165" "1.016" "1.050" "0.936" "1.012" "1.012" "1.071" "1.073" "0.811" "89.5" "104.2" "91.0" "93.9" "83.7" "90.6" "90.6" "95.9" "96.0" "72.6" "" "" "" "" "" "" "" "" "" "" "47.4" "57.8" "52.1" "43.3" "45.3" "50.4" "53.3" "52.3" "53.9" "72.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2347983332977388865" "False" "High" "IsMasterProtein" "Q9H900" "Protein zwilch homolog OS=Homo sapiens OX=9606 GN=ZWILCH PE=1 SV=2" "0.004" "False" "2.508" "1" "1" "1" "1" "591" "67.2" "6.27" "2.32" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf09817" "55055" "ENSG00000174442" "ZWILCH" "B3KVB8; hsa:55055; Q6N049; Q8N404; Q96SY7; Q9H900; Q9NWG7" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "0.969" "0.959" "0.813" "0.925" "0.942" "0.902" "0.786" "0.998" "2.550" "127.0" "123.1" "121.8" "103.3" "117.5" "119.7" "114.6" "99.8" "126.8" "324.0" "" "" "" "" "" "" "" "" "" "" "67.3" "68.2" "69.8" "47.6" "63.6" "66.6" "67.5" "54.5" "71.1" "324.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2283979429673317137" "False" "High" "IsMasterProtein" "A6NIH7" "Protein unc-119 homolog B OS=Homo sapiens OX=9606 GN=UNC119B PE=1 SV=1" "0.004" "False" "2.499" "4" "1" "1" "1" "251" "28.1" "5.68" "1.83" "1" "cell organization and biogenesis;transport;developmental processes" "cytosol;other cell component" "other molecular function" "Pf05351" "84747" "ENSG00000175970" "UNC119B" "A6NIH7; hsa:84747" "" "Trafficking of myristoylated proteins to the cilium" "1" "0" "1.162" "1.166" "0.889" "1.335" "1.205" "1.181" "1.199" "1.440" "3.295" "54.4" "63.2" "63.4" "48.4" "72.6" "65.5" "64.2" "65.2" "78.3" "179.2" "" "" "" "" "" "" "" "" "" "" "28.8" "35.0" "36.3" "22.3" "39.3" "36.4" "37.8" "35.6" "43.9" "179.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8893746772392115503" "False" "High" "IsMasterProtein" "Q6P1L5" "Protein FAM117B OS=Homo sapiens OX=9606 GN=FAM117B PE=1 SV=2" "0.004" "False" "2.493" "2" "1" "1" "1" "589" "61.9" "9.82" "1.65" "1" "" "" "" "Pf15388" "150864" "ENSG00000138439" "FAM117B" "hsa:150864; Q53QZ5; Q585T9; Q6P1L5; Q8N8W1; Q96Q34" "" "" "0" "0" "0.848" "0.805" "0.710" "0.540" "0.750" "0.789" "0.909" "0.406" "0.782" "29.8" "25.3" "24.0" "21.2" "16.1" "22.4" "23.6" "27.1" "12.1" "23.3" "" "" "" "" "" "" "" "" "" "" "15.8" "14.0" "13.7" "9.8" "8.7" "12.5" "13.9" "14.8" "6.8" "23.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1054050603788689952" "False" "High" "IsMasterProtein" "Q86YV0" "RAS protein activator like-3 OS=Homo sapiens OX=9606 GN=RASAL3 PE=1 SV=2" "0.004" "False" "2.491" "1" "1" "1" "1" "1011" "111.8" "8.75" "2.33" "1" "other biological processes" "other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00616" "64926" "ENSG00000105122" "RASAL3" "hsa:64926; Q86YV0; Q8N2T9; Q9H735" "Ras signaling" "Regulation of RAS by GAPs" "2" "0" "1.006" "0.757" "1.018" "0.782" "0.865" "1.132" "0.467" "0.926" "4.065" "29.2" "29.3" "22.1" "29.7" "22.8" "25.2" "33.0" "13.6" "27.0" "118.6" "" "" "" "" "" "" "" "" "" "" "15.4" "16.3" "12.6" "13.7" "12.3" "14.0" "19.4" "7.4" "15.1" "118.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4539117867176903484" "False" "High" "IsMasterProtein" "P50402" "Emerin OS=Homo sapiens OX=9606 GN=EMD PE=1 SV=1" "0.004" "False" "2.491" "3" "1" "1" "1" "254" "29.0" "5.50" "3.05" "1" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity" "Pf03020" "2010" "ENSG00000102119" "EMD" "hsa:2010; P50402; Q6FI02" "Arrhythmogenic right ventricular cardiomyopathy; Envelope proteins and their potential roles in EDMD physiopathology; Influence of laminopathies on Wnt signaling" "Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina; RHOG GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3757021002134428310" "False" "High" "IsMasterProtein" "Q8TBM8" "DnaJ homolog subfamily B member 14 OS=Homo sapiens OX=9606 GN=DNAJB14 PE=1 SV=1" "0.004" "False" "2.488" "2" "1" "1" "1" "379" "42.5" "8.59" "2.42" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf00226, Pf09320" "79982" "ENSG00000164031" "DNAJB14" "hsa:79982; Q6UXN1; Q7Z3P0; Q86TA7; Q86TM0; Q8TBM8; Q9GZU9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5045228690157758775" "False" "High" "IsMasterProtein" "Q9Y4E6" "WD repeat-containing protein 7 OS=Homo sapiens OX=9606 GN=WDR7 PE=1 SV=2" "0.004" "False" "2.486" "1" "1" "1" "1" "1490" "163.7" "6.92" "2.16" "1" "other biological processes" "other cell component" "" "Pf00400" "23335" "ENSG00000091157" "WDR7" "A7E2C8; hsa:23335; Q86UX5; Q86VP2; Q96PS7; Q9Y4E6" "" "" "0" "0" "1.692" "1.332" "1.600" "1.623" "1.282" "1.836" "1.228" "1.829" "3.082" "15.7" "26.5" "20.9" "25.0" "25.4" "20.1" "28.7" "19.2" "28.6" "48.2" "" "" "" "" "" "" "" "" "" "" "8.3" "14.7" "11.9" "11.5" "13.7" "11.2" "16.9" "10.5" "16.1" "48.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4503550903694701286" "False" "High" "IsMasterProtein" "O60504" "Vinexin OS=Homo sapiens OX=9606 GN=SORBS3 PE=1 SV=2" "0.004" "False" "2.483" "1" "1" "1" "1" "671" "75.3" "9.45" "2.93" "1" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00018, Pf02208, Pf14604" "10174" "ENSG00000120896" "SORBS3" "hsa:10174; O60504; Q5BJE4; Q6NX54; Q96FY4; Q9UQE4" "" "Smooth Muscle Contraction" "1" "0" "0.923" "0.925" "0.863" "0.996" "0.996" "0.807" "0.891" "0.886" "1.130" "260.3" "240.1" "240.6" "224.5" "259.2" "259.2" "210.0" "231.8" "230.7" "294.0" "" "" "" "" "" "" "" "" "" "" "137.8" "133.1" "137.8" "103.4" "140.3" "144.2" "123.6" "126.5" "129.4" "294.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4589433783542351991" "False" "High" "IsMasterProtein" "Q9NVU0" "DNA-directed RNA polymerase III subunit RPC5 OS=Homo sapiens OX=9606 GN=POLR3E PE=1 SV=1" "0.004" "False" "2.482" "1" "1" "1" "1" "708" "79.8" "6.47" "2.91" "1" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus" "" "Pf04801, Pf19725" "55718" "ENSG00000058600; ENSG00000284282" "POLR3E" "B4DL24; B4DUP6; H3BT11; hsa:55718; Q9BWF7; Q9H8W8; Q9H907; Q9NVU0; Q9P276" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4882780565556960985" "False" "High" "IsMasterProtein" "Q96MX3" "Zinc finger protein 48 OS=Homo sapiens OX=9606 GN=ZNF48 PE=1 SV=2" "0.004" "False" "2.480" "4" "1" "1" "1" "618" "67.8" "9.36" "2.53" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "197407" "ENSG00000180035" "ZNF48" "hsa:197407; Q15920; Q4G0R3; Q69YP3; Q96IL9; Q96MX3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6512701136026714686" "False" "High" "IsMasterProtein" "O95379" "Tumor necrosis factor alpha-induced protein 8 OS=Homo sapiens OX=9606 GN=TNFAIP8 PE=1 SV=1" "0.004" "False" "2.477" "5" "1" "2" "1" "198" "23.0" "7.93" "5.71" "1" "other biological processes" "nucleus;other cell component" "enzyme regulator activity" "Pf05527" "25816" "ENSG00000145779" "TNFAIP8" "B3KMH1; B3KMI2; B7Z713; hsa:25816; O95379; Q9P1Q1; Q9UER5; Q9UP47" "" "PI Metabolism" "1" "0" "0.855" "0.948" "0.839" "1.010" "0.903" "0.975" "0.946" "1.098" "1.004" "100.1" "85.6" "94.9" "84.1" "101.1" "90.4" "97.6" "94.7" "109.9" "100.6" "" "" "" "" "" "" "" "" "" "" "53.0" "47.5" "54.3" "38.7" "54.7" "50.3" "57.5" "51.7" "61.7" "100.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3087577180827751856" "False" "High" "IsMasterProtein" "Q15172" "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R5A PE=1 SV=1" "0.004" "False" "2.474" "2" "1" "1" "1" "486" "56.2" "6.71" "2.23" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01603" "5525" "ENSG00000066027" "PPP2R5A" "B2R6D2; B7Z7L2; D3DT99; hsa:5525; Q15172; Q2NL72; Q5VVB2; Q8TBI9" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Resolution of Sister Chromatid Cohesion; Separation of Sister Chromatids; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; PKR-mediated signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling" "27" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5073984553663010392" "False" "High" "IsMasterProtein" "Q86UV5" "Ubiquitin carboxyl-terminal hydrolase 48 OS=Homo sapiens OX=9606 GN=USP48 PE=1 SV=1" "0.004" "False" "2.473" "2" "1" "1" "1" "1035" "119.0" "6.05" "0.00" "1" "protein metabolism" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00443, Pf06337" "84196" "ENSG00000090686" "USP48" "B7ZKS7; hsa:84196; Q2M3I4; Q5SZI4; Q5T3T5; Q6NX53; Q86UV5; Q8N3F6; Q96F64; Q96IQ3; Q9H5N3; Q9H5T7; Q9NUJ6; Q9NXR0" "" "Ub-specific processing proteases" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "155528844813379728" "False" "High" "IsMasterProtein" "Q68CZ2" "Tensin-3 OS=Homo sapiens OX=9606 GN=TNS3 PE=1 SV=2" "0.004" "False" "2.470" "1" "1" "1" "1" "1445" "155.2" "6.81" "2.68" "1" "other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00017, Pf08416, Pf10409" "64759" "ENSG00000136205" "TNS3" "B2RNV1; hsa:64759; Q68CZ2; Q6IPQ2; Q8IZW7; Q8NAD0; Q96PE0; Q96S48" "" "MET interacts with TNS proteins" "1" "0" "1.086" "1.005" "1.421" "1.200" "1.188" "1.615" "1.201" "1.320" "3.034" "58.6" "63.6" "58.9" "83.3" "70.3" "69.6" "94.7" "70.4" "77.4" "177.8" "" "" "" "" "" "" "" "" "" "" "31.0" "35.3" "33.7" "38.4" "38.0" "38.7" "55.7" "38.4" "43.4" "177.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1189012646270467424" "False" "High" "IsMasterProtein" "Q9H5Q4" "Dimethyladenosine transferase 2, mitochondrial OS=Homo sapiens OX=9606 GN=TFB2M PE=1 SV=1" "0.004" "False" "2.470" "2" "1" "2" "1" "396" "45.3" "9.19" "5.96" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00398" "64216" "ENSG00000162851" "TFB2M" "hsa:64216; Q9H5Q4; Q9H626" "Energy metabolism; Mitochondrial gene expression" "Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7261913870359179685" "False" "High" "IsMasterProtein" "O75165" "DnaJ homolog subfamily C member 13 OS=Homo sapiens OX=9606 GN=DNAJC13 PE=1 SV=5" "0.004" "False" "2.468" "0" "1" "1" "1" "2243" "254.3" "6.74" "0.00" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf00226, Pf14237, Pf19432" "23317" "ENSG00000138246" "DNAJC13" "hsa:23317; O75165; Q3L0T1; Q6PI82; Q6UJ77; Q6ZSW1; Q6ZUT5; Q86XG3; Q96DC1; Q9BWK9" "" "Neutrophil degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7543040224215837261" "False" "High" "IsMasterProtein" "Q96EY4" "Translation machinery-associated protein 16 OS=Homo sapiens OX=9606 GN=TMA16 PE=1 SV=2" "0.004" "False" "2.461" "3" "1" "1" "1" "203" "23.8" "9.26" "3.06" "1" "other biological processes" "nucleus" "other molecular function" "Pf11176" "55319" "ENSG00000198498" "TMA16" "hsa:55319; Q0P6E4; Q0P6J1; Q96EY4; Q9NUR7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-998134309870178967" "False" "High" "IsMasterProtein" "P47974" "mRNA decay activator protein ZFP36L2 OS=Homo sapiens OX=9606 GN=ZFP36L2 PE=1 SV=3" "0.004" "False" "2.453" "2" "1" "1" "1" "494" "51.0" "8.16" "1.82" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf04553" "678" "ENSG00000152518" "ZFP36L2" "hsa:678; P47974; Q53TB4; Q9BSJ3" "Pre-implantation embryo; TYROBP causal network in microglia" "M-decay: degradation of maternal mRNAs by maternally stored factors" "3" "0" "1.084" "0.997" "1.143" "1.152" "1.074" "0.768" "0.686" "1.006" "3.665" "34.5" "37.4" "34.4" "39.5" "39.8" "37.1" "26.5" "23.7" "34.7" "126.5" "" "" "" "" "" "" "" "" "" "" "18.3" "20.7" "19.7" "18.2" "21.5" "20.6" "15.6" "12.9" "19.5" "126.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1430598846084428850" "False" "High" "IsMasterProtein" "Q3B726" "DNA-directed RNA polymerase I subunit RPA43 OS=Homo sapiens OX=9606 GN=POLR1F PE=1 SV=1" "0.004" "False" "2.450" "3" "1" "1" "1" "338" "37.4" "6.98" "3.01" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf03876, Pf17875" "221830" "ENSG00000105849" "POLR1F" "A0PJ45; B7Z724; hsa:221830; Q3B726" "Pyrimidine metabolism; 2q13 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "1" "" "-8867340794532680383" "False" "High" "IsMasterProtein" "O94967" "WD repeat-containing protein 47 OS=Homo sapiens OX=9606 GN=WDR47 PE=1 SV=1" "0.004" "False" "2.446" "1" "1" "1" "1" "919" "101.9" "5.94" "2.76" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;other cell component" "" "Pf00400, Pf17814" "22911" "ENSG00000085433" "WDR47" "A8MX09; hsa:22911; O94967; Q5TYV7; Q5TYV8; Q5TYV9; Q8IXT7; Q8IYU9" "" "" "0" "0" "0.885" "0.959" "0.993" "0.998" "0.969" "0.827" "0.999" "1.069" "0.630" "256.5" "227.1" "246.0" "254.7" "255.9" "248.5" "212.2" "256.2" "274.1" "161.5" "" "" "" "" "" "" "" "" "" "" "135.8" "125.9" "140.9" "117.3" "138.5" "138.3" "124.9" "139.9" "153.7" "161.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8574893947770882391" "False" "High" "IsMasterProtein" "P53701" "Holocytochrome c-type synthase OS=Homo sapiens OX=9606 GN=HCCS PE=1 SV=1" "0.005" "False" "2.443" "4" "1" "1" "1" "268" "30.6" "6.68" "2.31" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion" "other molecular function" "Pf01265" "3052" "ENSG00000004961" "HCCS" "B3KUS1; hsa:3052; P53701; Q502X8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7011076575076357199" "False" "High" "IsMasterProtein" "O00442" "RNA 3'-terminal phosphate cyclase OS=Homo sapiens OX=9606 GN=RTCA PE=1 SV=1" "0.005" "False" "2.441" "2" "1" "1" "1" "366" "39.3" "7.85" "3.31" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01137, Pf05189" "8634" "ENSG00000137996" "RTCA" "hsa:8634; O00442; Q5VVL5; Q5VVL6; Q96E99" "" "" "0" "0" "1.069" "1.005" "1.114" "0.932" "1.060" "1.044" "0.913" "0.938" "0.766" "199.7" "213.5" "200.7" "222.5" "186.1" "211.6" "208.4" "182.4" "187.2" "153.0" "" "" "" "" "" "" "" "" "" "" "105.7" "118.4" "114.9" "102.5" "100.7" "117.7" "122.6" "99.5" "105.0" "153.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5264367170864335030" "False" "High" "IsMasterProtein" "Q96K76" "Ubiquitin carboxyl-terminal hydrolase 47 OS=Homo sapiens OX=9606 GN=USP47 PE=1 SV=3" "0.005" "False" "2.434" "1" "1" "1" "1" "1375" "157.2" "5.08" "2.62" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf19718" "55031" "ENSG00000170242" "USP47" "B3KXF5; E9PM46; hsa:55031; Q658U0; Q86Y73; Q8TEP6; Q96K76; Q9BWI0; Q9NWN1" "" "Ub-specific processing proteases" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6289103138971436577" "False" "High" "IsMasterProtein" "Q92520" "Protein FAM3C OS=Homo sapiens OX=9606 GN=FAM3C PE=1 SV=1" "0.005" "False" "2.433" "4" "1" "1" "1" "227" "24.7" "8.29" "2.20" "1" "signal transduction" "non-structural extracellular;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf15711" "10447" "ENSG00000196937" "FAM3C" "A6NDN2; A8K3R7; hsa:10447; Q92520" "" "Platelet degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4417786093828078874" "False" "High" "IsMasterProtein" "Q9H1A4" "Anaphase-promoting complex subunit 1 OS=Homo sapiens OX=9606 GN=ANAPC1 PE=1 SV=1" "0.005" "False" "2.423" "0" "1" "1" "1" "1944" "216.4" "6.30" "1.85" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf12859, Pf18122, Pf20518, Pf21282" "64682" "ENSG00000153107" "ANAPC1" "hsa:64682; Q2M3H8; Q9BSE6; Q9H1A4; Q9H8D0" "Cell cycle; 2q13 copy number variation syndrome" "Antigen processing: Ubiquitination & Proteasome degradation; Separation of Sister Chromatids; Senescence-Associated Secretory Phenotype (SASP); APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "20" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4170065577155678868" "False" "High" "IsMasterProtein" "Q5QP82" "DDB1- and CUL4-associated factor 10 OS=Homo sapiens OX=9606 GN=DCAF10 PE=1 SV=1" "0.005" "False" "2.422" "2" "1" "1" "1" "559" "60.5" "7.50" "2.01" "1" "protein metabolism;other metabolic processes" "nucleus;other cell component" "" "Pf00400" "79269" "ENSG00000122741" "DCAF10" "A4VCJ5; hsa:79269; Q32NE2; Q5QP82; Q8N2Q5; Q96ET5; Q9BTQ5; Q9H5P6" "" "Neddylation" "1" "0" "1.023" "1.028" "1.171" "0.919" "1.044" "1.067" "0.857" "0.966" "0.910" "72.8" "74.6" "74.9" "85.3" "67.0" "76.1" "77.7" "62.4" "70.4" "66.3" "" "" "" "" "" "" "" "" "" "" "38.6" "41.3" "42.9" "39.3" "36.2" "42.3" "45.7" "34.1" "39.5" "66.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8640947955125983665" "False" "High" "IsMasterProtein" "Q9Y5A7" "NEDD8 ultimate buster 1 OS=Homo sapiens OX=9606 GN=NUB1 PE=1 SV=2" "0.005" "False" "2.419" "1" "1" "1" "1" "615" "70.5" "5.96" "2.67" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "" "Pf00627, Pf18037" "51667" "ENSG00000013374" "NUB1" "hsa:51667; O95422; Q75MR9; Q8IX22; Q9BXR2; Q9Y5A7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-981252296573627161" "False" "High" "IsMasterProtein" "Q8NCN4" "E3 ubiquitin-protein ligase RNF169 OS=Homo sapiens OX=9606 GN=RNF169 PE=1 SV=2" "0.005" "False" "2.418" "2" "1" "1" "1" "708" "77.1" "9.10" "0.00" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf13920" "254225" "ENSG00000166439" "RNF169" "hsa:254225; Q6N015; Q8NCN4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9146373126346510516" "False" "High" "IsMasterProtein" "Q96SL8" "Flt3-interacting zinc finger protein 1 OS=Homo sapiens OX=9606 GN=FIZ1 PE=1 SV=2" "0.005" "False" "2.407" "2" "1" "1" "1" "496" "52.0" "8.19" "2.86" "1" "other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00096" "84922" "ENSG00000179943" "FIZ1" "A2RU72; Q6ZMJ7; Q96SL8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2723380110301134702" "False" "High" "IsMasterProtein" "Q9UKS6" "Protein kinase C and casein kinase substrate in neurons protein 3 OS=Homo sapiens OX=9606 GN=PACSIN3 PE=1 SV=2" "0.005" "False" "2.405" "2" "1" "1" "1" "424" "48.5" "6.18" "2.42" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00611, Pf14604" "29763" "ENSG00000165912" "PACSIN3" "A6NH84; hsa:29763; Q9H331; Q9NWV9; Q9UKS6" "" "Clathrin-mediated endocytosis" "1" "0" "1.291" "1.166" "1.540" "1.210" "1.177" "0.889" "0.705" "0.915" "4.947" "43.9" "56.7" "51.2" "67.7" "53.2" "51.7" "39.1" "31.0" "40.2" "217.4" "" "" "" "" "" "" "" "" "" "" "23.3" "31.5" "29.3" "31.2" "28.8" "28.8" "23.0" "16.9" "22.6" "217.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6570966043889327404" "False" "High" "IsMasterProtein" "Q15437" "Protein transport protein Sec23B OS=Homo sapiens OX=9606 GN=SEC23B PE=1 SV=2" "0.005" "False" "2.404" "1" "1" "1" "1" "767" "86.4" "6.89" "2.24" "1" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10483" "ENSG00000101310" "SEC23B" "D3DW33; hsa:10483; Q15437; Q503A9; Q5W183; Q9BS15; Q9BSI2; Q9H1D7" "Sterol regulatory element-binding proteins (SREBP) signaling" "" "1" "0" "1.090" "1.051" "0.907" "1.159" "0.880" "0.982" "0.986" "0.950" "1.224" "50.0" "54.5" "52.5" "45.3" "57.9" "44.0" "49.1" "49.3" "47.5" "61.2" "" "" "" "" "" "" "" "" "" "" "26.5" "30.2" "30.1" "20.9" "31.3" "24.5" "28.9" "26.9" "26.6" "61.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5294861354005901566" "False" "High" "IsMasterProtein" "Cont_P17690" "Beta-2-glycoprotein 1 OS=Bos taurus OX=9913 GN=APOH PE=1 SV=4" "0.006" "True" "2.388" "3" "1" "1" "1" "345" "38.2" "8.15" "2.31" "1" "" "non-structural extracellular" "other molecular function" "Pf00084, Pf09014" "281006" "" "APOH" "bta:281006; P17690; Q148G1; Q28052" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1159360155636632788" "False" "High" "IsMasterProtein" "Q96RT6" "cTAGE family member 2 OS=Homo sapiens OX=9606 GN=CTAGE1 PE=1 SV=2" "0.006" "False" "2.384" "1" "1" "1" "1" "745" "85.2" "6.16" "2.48" "1" "transport" "other membranes;ER/Golgi" "" "" "64693" "ENSG00000212710; ENSG00000282841" "CTAGE1" "A2RUF2; hsa:64693; Q96RT6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8966374980505742475" "False" "High" "IsMasterProtein" "Q15047" "Histone-lysine N-methyltransferase SETDB1 OS=Homo sapiens OX=9606 GN=SETDB1 PE=1 SV=1" "0.006" "False" "2.382" "1" "1" "1" "1" "1291" "143.1" "6.02" "1.80" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00856, Pf01429, Pf05033, Pf18300, Pf18358, Pf18359" "9869" "ENSG00000143379" "SETDB1" "A6NEW2; hsa:9869; Q15047; Q5SZD8; Q5SZD9; Q5SZE0; Q5SZE7; Q96GM9" "Histone modifications; Pleural mesothelioma" "PKMTs methylate histone lysines" "3" "0" "1.081" "1.005" "1.068" "1.149" "1.149" "1.323" "0.991" "1.152" "3.901" "90.5" "97.8" "91.0" "96.7" "103.9" "104.0" "119.7" "89.7" "104.2" "353.0" "" "" "" "" "" "" "" "" "" "" "47.9" "54.2" "52.1" "44.5" "56.2" "57.9" "70.5" "49.0" "58.5" "353.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6937145884149963662" "False" "High" "IsMasterProtein" "Q15306" "Interferon regulatory factor 4 OS=Homo sapiens OX=9606 GN=IRF4 PE=1 SV=1" "0.006" "False" "2.381" "2" "1" "1" "1" "451" "51.7" "6.86" "2.20" "1" "cell organization and biogenesis;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605, Pf10401" "3662" "ENSG00000137265" "IRF4" "hsa:3662; Q15306; Q5VUI7; Q99660" "B cell receptor signaling pathway; Apoptosis; Vitamin D receptor pathway; Pre-implantation embryo; Development of pulmonary dendritic cells and macrophage subsets; Prion disease pathway; White fat cell differentiation; Th17 cell differentiation pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2; Type II interferon signaling; T-cell receptor signaling pathway" "Interleukin-4 and Interleukin-13 signaling; Nuclear events stimulated by ALK signaling in cancer; Interferon gamma signaling; Interferon alpha/beta signaling" "15" "0" "0.995" "1.177" "1.250" "1.017" "0.973" "0.887" "1.090" "1.132" "2.982" "49.8" "49.5" "58.6" "62.2" "50.6" "48.4" "44.1" "54.3" "56.3" "148.4" "" "" "" "" "" "" "" "" "" "" "26.4" "27.5" "33.6" "28.7" "27.4" "26.9" "26.0" "29.6" "31.6" "148.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7106533515535511067" "False" "High" "IsMasterProtein" "Q969E8" "Pre-rRNA-processing protein TSR2 homolog OS=Homo sapiens OX=9606 GN=TSR2 PE=1 SV=1" "0.006" "False" "2.379" "4" "1" "2" "1" "191" "20.9" "4.39" "7.18" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf10273" "90121" "ENSG00000158526" "TSR2" "hsa:90121; Q969E8" "" "" "0" "0" "1.065" "1.045" "1.019" "1.051" "1.079" "0.925" "0.933" "0.988" "1.045" "327.3" "348.6" "342.1" "333.5" "344.1" "353.1" "302.8" "305.2" "323.3" "342.1" "" "" "" "" "" "" "" "" "" "" "173.3" "193.3" "195.9" "153.6" "186.2" "196.4" "178.2" "166.6" "181.4" "342.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2167578291450993964" "False" "High" "IsMasterProtein" "Q8N697" "Solute carrier family 15 member 4 OS=Homo sapiens OX=9606 GN=SLC15A4 PE=1 SV=1" "0.006" "False" "2.378" "1" "1" "1" "1" "577" "62.0" "9.00" "2.29" "1" "stress response;transport;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle" "transporter activity" "Pf00854" "121260" "ENSG00000139370" "SLC15A4" "A6H8Y9; B3KTK1; hsa:121260; Q71M34; Q7Z5F8; Q8N697; Q8TAH0" "Carnosine metabolism of glial cells" "Neutrophil degranulation; Proton/oligopeptide cotransporters" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1322674044200343444" "False" "High" "IsMasterProtein" "Q12789" "General transcription factor 3C polypeptide 1 OS=Homo sapiens OX=9606 GN=GTF3C1 PE=1 SV=4" "0.006" "False" "2.378" "0" "1" "1" "1" "2109" "238.7" "7.30" "2.78" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04182" "2975" "ENSG00000077235" "GTF3C1" "B2RP21; hsa:2975; Q12789; Q12838; Q6DKN9; Q9Y4W9" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "3" "0" "0.991" "0.953" "1.179" "1.174" "1.012" "0.939" "0.982" "1.226" "3.878" "36.5" "36.2" "34.8" "43.1" "42.9" "37.0" "34.3" "35.9" "44.8" "141.7" "" "" "" "" "" "" "" "" "" "" "19.3" "20.1" "19.9" "19.8" "23.2" "20.6" "20.2" "19.6" "25.1" "141.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4327969175985067622" "False" "High" "IsMasterProtein" "Q6I9Y2" "THO complex subunit 7 homolog OS=Homo sapiens OX=9606 GN=THOC7 PE=1 SV=3" "0.006" "False" "2.377" "3" "1" "3" "1" "204" "23.7" "5.67" "8.33" "1" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05615" "80145" "ENSG00000163634" "THOC7" "hsa:80145; Q6I9Y2; Q6P1L3; Q8WUF2; Q9H5H0" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "1.077" "1.229" "1.163" "1.085" "1.237" "1.144" "1.118" "1.094" "2.216" "119.4" "128.7" "146.7" "138.9" "129.6" "147.7" "136.6" "133.5" "130.6" "264.6" "" "" "" "" "" "" "" "" "" "" "63.2" "71.3" "84.0" "64.0" "70.1" "82.1" "80.4" "72.9" "73.3" "264.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5119048535094086908" "False" "High" "IsMasterProtein" "P82912" "Small ribosomal subunit protein uS11m OS=Homo sapiens OX=9606 GN=MRPS11 PE=1 SV=2" "0.006" "False" "2.374" "6" "1" "1" "1" "194" "20.6" "10.81" "2.45" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00411" "64963" "ENSG00000181991" "MRPS11" "B2RD52; hsa:64963; P82912; Q969D7; Q96GI3; Q9BYC3" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4696215040566855502" "False" "High" "IsMasterProtein" "Q9H446" "RWD domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RWDD1 PE=1 SV=1" "0.006" "False" "2.370" "3" "1" "1" "1" "243" "27.9" "4.20" "2.88" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other cell component" "" "Pf05773, Pf16543" "51389" "ENSG00000111832" "RWDD1" "A8K3W2; A8MT24; hsa:51389; Q9H446; Q9Y313; Q9Y6B3" "" "Protein hydroxylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2714987798271116551" "False" "High" "IsMasterProtein" "Q9BUE0" "Mediator of RNA polymerase II transcription subunit 18 OS=Homo sapiens OX=9606 GN=MED18 PE=1 SV=1" "0.006" "False" "2.363" "4" "1" "1" "1" "208" "23.6" "6.54" "2.51" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09637" "54797" "ENSG00000130772; ENSG00000284944" "MED18" "D3DPM1; hsa:54797; Q9BUE0; Q9NXU9" "" "RSV-host interactions; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3934808494784224808" "False" "High" "IsMasterProtein" "Q96FJ2" "Dynein light chain 2, cytoplasmic OS=Homo sapiens OX=9606 GN=DYNLL2 PE=1 SV=1" "0.006" "False" "2.355" "8" "1" "2" "1" "89" "10.3" "7.37" "5.29" "1" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf01221" "140735" "ENSG00000264364" "DYNLL2" "B2R5B4; hsa:140735; Q96FJ2" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome; Vasopressin-regulated water reabsorption" "Separation of Sister Chromatids; MHC class II antigen presentation; Aggrephagy; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Intraflagellar transport; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Macroautophagy; Activation of BMF and translocation to mitochondria" "19" "0" "0.976" "1.080" "0.836" "0.992" "1.050" "0.990" "1.171" "1.113" "0.860" "390.3" "381.0" "421.7" "326.5" "387.2" "409.9" "386.5" "456.9" "434.3" "335.6" "" "" "" "" "" "" "" "" "" "" "206.7" "211.3" "241.5" "150.3" "209.5" "228.0" "227.5" "249.4" "243.7" "335.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7099090004337322375" "False" "High" "IsMasterProtein" "P63167" "Dynein light chain 1, cytoplasmic OS=Homo sapiens OX=9606 GN=DYNLL1 PE=1 SV=1" "0.006" "False" "2.351" "8" "1" "1" "1" "89" "10.4" "7.40" "2.71" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01221" "8655" "ENSG00000088986" "DYNLL1" "hsa:8655; P63167; Q15701" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome; Vasopressin-regulated water reabsorption" "MHC class II antigen presentation; COPI-mediated anterograde transport; Neutrophil degranulation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Intraflagellar transport; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Macroautophagy; Activation of BIM and translocation to mitochondria" "28" "0" "0.845" "1.011" "0.794" "0.983" "0.995" "0.776" "1.023" "1.110" "0.954" "164.2" "138.7" "165.9" "130.4" "161.3" "163.4" "127.4" "167.9" "182.2" "156.6" "" "" "" "" "" "" "" "" "" "" "86.9" "76.9" "95.0" "60.0" "87.3" "90.9" "75.0" "91.7" "102.2" "156.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1552810518553592315" "False" "High" "IsMasterProtein" "P49662" "Caspase-4 OS=Homo sapiens OX=9606 GN=CASP4 PE=1 SV=1" "0.006" "False" "2.350" "2" "1" "1" "1" "377" "43.2" "6.00" "2.27" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00619, Pf00656" "837" "ENSG00000196954" "CASP4" "A2NHL8; A2NHL9; A2NHM0; B3KPZ9; B4DJH5; B4E2D2; hsa:837; O95601; P49662; Q7KYX7; Q9UG96" "Apoptosis modulation and signaling; Apoptosis" "NOD1/2 Signaling Pathway; Pyroptosis" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1899154642705730358" "False" "High" "IsMasterProtein" "Q9UNK0" "Syntaxin-8 OS=Homo sapiens OX=9606 GN=STX8 PE=1 SV=2" "0.006" "False" "2.348" "3" "1" "1" "1" "236" "26.9" "4.98" "2.86" "1" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05739" "9482" "ENSG00000170310" "STX8" "hsa:9482; O60712; Q53XT8; Q9UNK0" "" "" "0" "0" "0.994" "0.815" "0.901" "0.874" "0.746" "1.005" "1.143" "1.056" "0.739" "115.2" "114.4" "93.8" "103.8" "100.6" "85.9" "115.8" "131.6" "121.6" "85.1" "" "" "" "" "" "" "" "" "" "" "61.0" "63.4" "53.7" "47.8" "54.5" "47.8" "68.1" "71.9" "68.2" "85.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7850572796846009162" "False" "High" "IsMasterProtein" "P52435" "DNA-directed RNA polymerase II subunit RPB11-a OS=Homo sapiens OX=9606 GN=POLR2J PE=1 SV=1" "0.006" "False" "2.347" "9" "1" "1" "1" "117" "13.3" "5.86" "2.82" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01193, Pf13656" "5439" "ENSG00000005075" "POLR2J" "A5D6V8; hsa:5439; O43375; P52435" "Pyrimidine metabolism; Eukaryotic transcription initiation" "RNA polymerase II transcribes snRNA genes; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Polymerase II Pre-transcription Events; mRNA Capping; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; TP53 Regulates Transcription of DNA Repair Genes; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Inhibition of DNA recombination at telomere" "43" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6950244637905263726" "False" "High" "IsMasterProtein" "Q9Y3B4" "Splicing factor 3B subunit 6 OS=Homo sapiens OX=9606 GN=SF3B6 PE=1 SV=1" "0.006" "False" "2.342" "7" "1" "1" "1" "125" "14.6" "9.38" "2.43" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "nucleic acid binding activity" "Pf00076" "51639" "ENSG00000115128" "SF3B6" "hsa:51639; Q53TM1; Q9Y3B4" "" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "2" "0" "1.062" "1.126" "0.891" "0.957" "0.947" "0.874" "0.959" "0.966" "1.100" "305.4" "324.4" "343.8" "272.2" "292.2" "289.1" "266.8" "292.8" "295.0" "335.9" "" "" "" "" "" "" "" "" "" "" "161.7" "179.8" "196.9" "125.4" "158.1" "160.8" "157.0" "159.8" "165.5" "335.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1528073227460313936" "False" "High" "IsMasterProtein" "Q9H9T3" "Elongator complex protein 3 OS=Homo sapiens OX=9606 GN=ELP3 PE=1 SV=2" "0.006" "False" "2.340" "1" "1" "1" "1" "547" "62.2" "8.88" "2.28" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf04055, Pf16199" "55140" "ENSG00000134014" "ELP3" "B4DE19; B4DIG1; E2QRI5; hsa:55140; Q53G84; Q6AWB0; Q9BVF7; Q9H9T3; Q9NVZ1" "Ethanol effects on histone modifications; HDAC6 interactions in the central nervous system" "HATs acetylate histones" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-715832753700784142" "False" "High" "IsMasterProtein" "P22830" "Ferrochelatase, mitochondrial OS=Homo sapiens OX=9606 GN=FECH PE=1 SV=2" "0.006" "False" "2.338" "4" "1" "1" "1" "423" "47.8" "8.73" "0.00" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00762" "2235" "ENSG00000066926" "FECH" "A8KA72; hsa:2235; P22830; Q8IXN1; Q8NAN0" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "Mitochondrial protein degradation; Heme biosynthesis" "4" "0" "0.954" "1.022" "1.220" "1.190" "1.139" "1.172" "1.277" "0.983" "0.798" "38.7" "37.0" "39.6" "47.3" "46.1" "44.1" "45.4" "49.5" "38.1" "30.9" "" "" "" "" "" "" "" "" "" "" "20.5" "20.5" "22.7" "21.8" "24.9" "24.5" "26.7" "27.0" "21.4" "30.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2661255315618113722" "False" "High" "IsMasterProtein" "O43493" "Trans-Golgi network integral membrane protein 2 OS=Homo sapiens OX=9606 GN=TGOLN2 PE=1 SV=4" "0.006" "False" "2.334" "2" "1" "1" "1" "437" "45.9" "5.63" "1.89" "1" "" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle" "" "Pf17818" "10618" "ENSG00000152291; ENSG00000292253" "TGOLN2" "B2R686; B8ZZ88; D6W5K3; F8W8W7; F8WBK2; hsa:10618; J3KQ45; O15282; O43492; O43493; O43499; O43500; O43501; Q53G68; Q53GV2; Q6MZV1; Q6ZTM7; Q8N6T8; Q92760; Q96QL2" "" "Golgi Associated Vesicle Biogenesis; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network" "6" "0" "0.944" "1.005" "1.019" "1.138" "0.782" "0.869" "0.974" "1.061" "0.562" "48.4" "45.6" "48.6" "49.3" "55.1" "37.8" "42.0" "47.1" "51.3" "27.2" "" "" "" "" "" "" "" "" "" "" "25.6" "25.3" "27.8" "22.7" "29.8" "21.0" "24.7" "25.7" "28.8" "27.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6933748794683119105" "False" "High" "IsMasterProtein" "P60673" "Profilin-3 OS=Homo sapiens OX=9606 GN=PFN3 PE=1 SV=1" "0.006" "False" "2.332" "7" "1" "1" "1" "137" "14.6" "9.26" "0.00" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00235" "345456" "ENSG00000196570" "PFN3" "A2RUL3; hsa:345456; P60673" "Physico-chemical features and toxicity-associated pathways; 5q35 copy number variation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3793795971274937654" "False" "High" "IsMasterProtein" "Q96S59" "Ran-binding protein 9 OS=Homo sapiens OX=9606 GN=RANBP9 PE=1 SV=1" "0.006" "False" "2.332" "1" "1" "1" "1" "729" "77.8" "6.79" "2.01" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00622, Pf08513, Pf10607" "10048" "ENSG00000010017" "RANBP9" "A0PJA2; B2R8E1; hsa:10048; O94764; Q6P3T7; Q7LBR2; Q7Z7F9; Q96S59" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Ciliary landscape" "RAF/MAP kinase cascade; L1CAM interactions; MET activates RAS signaling" "5" "0" "1.066" "0.911" "0.966" "0.869" "0.920" "1.111" "0.880" "0.839" "1.344" "90.6" "96.5" "82.5" "87.5" "78.7" "83.3" "100.6" "79.7" "76.0" "121.7" "" "" "" "" "" "" "" "" "" "" "47.9" "53.5" "47.3" "40.3" "42.6" "46.3" "59.2" "43.5" "42.6" "121.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7958389170144649522" "False" "High" "IsMasterProtein" "P45983" "Mitogen-activated protein kinase 8 OS=Homo sapiens OX=9606 GN=MAPK8 PE=1 SV=2" "0.006" "False" "2.328" "2" "1" "1" "1" "427" "48.3" "6.89" "2.84" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "5599" "ENSG00000107643" "MAPK8" "B5BTZ5; B7ZLV4; D3DX88; D3DX92; hsa:5599; P45983; Q15709; Q15712; Q15713; Q308M2" "Osteoclast signaling; Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Thymic stromal lymphopoietin (TSLP) signaling pathway; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Nanoparticle triggered regulated necrosis; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; IL-3 signaling pathway; Nod-like receptor (NLR) signaling pathway; Transcriptional activation by NRF2 in response to phytochemicals; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; Fas ligand pathway and stress induction of heat shock proteins; RAC1/PAK1/p38/MMP2 pathway; Transcription factor regulation in adipogenesis; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Wnt signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; Canonical and non-canonical TGF-B signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; PDGFR-beta pathway; Wnt signaling in kidney disease; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Ethanol metabolism production of ROS by CYP2E1; Wnt signaling; miRNA role in immune response in sepsis; Neovascularization processes; Non-genomic actions of 1,25 dihydroxyvitamin D3; NRF2-ARE regulation; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Signal transduction through IL1R; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Regulatory circuits of the STAT3 signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Gastrin signaling pathway; Hepatitis B infection; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; Pleural mesothelioma; CCL18 signaling pathway; Alzheimer's disease; Th17 cell differentiation pathway; GDNF signaling; Roles of ceramides in development of insulin resistance; IL-26 signaling pathways; 10q11.21q11.23 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; 5q35 copy number variation; 13q12.12 copy number variation; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Signaling by ALK fusions and activated point mutants; NRAGE signals death through JNK; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; WNT5:FZD7-mediated leishmania damping; DSCAM interactions; Activation of BIM and translocation to mitochondria ; Activation of the AP-1 family of transcription factors; NRIF signals cell death from the nucleus; Activation of BMF and translocation to mitochondria; Interleukin-38 signaling" "99" "0" "0.808" "0.942" "1.235" "1.235" "1.390" "1.138" "1.225" "1.292" "1.666" "155.5" "125.7" "146.5" "192.0" "192.1" "216.2" "177.0" "190.6" "201.0" "259.1" "" "" "" "" "" "" "" "" "" "" "82.4" "69.7" "83.9" "88.4" "103.9" "120.3" "104.1" "104.0" "112.7" "259.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5498683654784928386" "False" "High" "IsMasterProtein" "Q99541" "Perilipin-2 OS=Homo sapiens OX=9606 GN=PLIN2 PE=1 SV=2" "0.006" "False" "2.325" "2" "1" "1" "1" "437" "48.0" "6.80" "2.55" "1" "cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf03036" "123" "ENSG00000147872" "PLIN2" "hsa:123; Q99541; Q9BSC3" "Adipogenesis" "PPARA activates gene expression; Late endosomal microautophagy; Lipophagy; Chaperone Mediated Autophagy" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7247108035044904633" "False" "High" "IsMasterProtein" "P62244" "Small ribosomal subunit protein uS8 OS=Homo sapiens OX=9606 GN=RPS15A PE=1 SV=2" "0.006" "False" "2.321" "5" "1" "1" "1" "130" "14.8" "10.13" "3.42" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00410" "6210" "ENSG00000134419" "RPS15A" "hsa:6210; P39027; P39031; P62244; Q3MHD9; Q8C023; Q9BV24" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.995" "0.918" "1.074" "1.018" "1.166" "1.190" "1.197" "1.286" "1.019" "368.9" "366.9" "338.7" "396.2" "375.7" "430.0" "439.2" "441.5" "474.5" "376.0" "" "" "" "" "" "" "" "" "" "" "195.3" "203.4" "194.0" "182.5" "203.2" "239.2" "258.5" "241.0" "266.2" "376.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6445951316860718443" "False" "High" "IsMasterProtein" "O60343" "TBC1 domain family member 4 OS=Homo sapiens OX=9606 GN=TBC1D4 PE=1 SV=2" "0.006" "False" "2.318" "1" "1" "1" "1" "1298" "146.5" "7.01" "2.18" "1" "transport;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00566, Pf00640, Pf11830" "9882" "ENSG00000136111" "TBC1D4" "A7E2X8; B4DU25; B4E235; B6ETN8; B6ETN9; hsa:9882; O60343; Q5W0B9; Q68D14" "Ciliary landscape; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7917199320651257178" "False" "High" "IsMasterProtein" "P53801" "Pituitary tumor-transforming gene 1 protein-interacting protein OS=Homo sapiens OX=9606 GN=PTTG1IP PE=1 SV=1" "0.006" "False" "2.314" "4" "1" "1" "1" "180" "20.3" "8.79" "2.54" "1" "transport;other biological processes" "nucleus;other cell component" "other molecular function" "" "754" "ENSG00000183255" "PTTG1IP" "B2RDP7; D3DSL9; hsa:754; P53801; Q9NS09" "" "" "0" "0" "1.023" "1.137" "1.054" "0.916" "1.026" "0.969" "1.212" "1.014" "0.572" "141.7" "145.0" "161.1" "149.3" "129.8" "145.4" "137.3" "171.8" "143.7" "81.0" "" "" "" "" "" "" "" "" "" "" "75.0" "80.4" "92.3" "68.8" "70.2" "80.9" "80.8" "93.8" "80.6" "81.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8070932965104358622" "False" "High" "IsMasterProtein" "Q86YS7" "C2 domain-containing protein 5 OS=Homo sapiens OX=9606 GN=C2CD5 PE=1 SV=1" "0.006" "False" "2.312" "1" "1" "1" "1" "1000" "110.4" "5.69" "2.63" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00168" "9847" "ENSG00000111731" "C2CD5" "B4DJ03; B4DRN7; B7ZLL0; F5H2A1; F5H5R1; hsa:9847; O60280; Q17RY7; Q7Z619; Q86SU3; Q86YS7" "" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "1" "0" "1.137" "1.160" "1.214" "1.186" "1.019" "1.116" "1.093" "0.979" "0.964" "85.5" "97.2" "99.2" "103.8" "101.4" "87.1" "95.4" "93.4" "83.7" "82.4" "" "" "" "" "" "" "" "" "" "" "45.3" "53.9" "56.8" "47.8" "54.8" "48.4" "56.2" "51.0" "47.0" "82.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8789508812130398643" "False" "High" "IsMasterProtein" "Q9BTE7" "DCN1-like protein 5 OS=Homo sapiens OX=9606 GN=DCUN1D5 PE=1 SV=1" "0.006" "False" "2.312" "3" "1" "2" "1" "237" "27.5" "5.58" "4.68" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03556" "84259" "ENSG00000137692" "DCUN1D5" "hsa:84259; Q3ZTT2; Q9BTE7" "" "Neddylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2963377560695435167" "False" "High" "IsMasterProtein" "Q96P47" "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 OS=Homo sapiens OX=9606 GN=AGAP3 PE=1 SV=2" "0.006" "False" "2.310" "1" "1" "1" "1" "875" "95.0" "7.97" "2.84" "1" "protein metabolism;other metabolic processes;stress response" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00071, Pf01412, Pf12796" "116988" "ENSG00000133612" "AGAP3" "B3KNZ8; E9PAL8; hsa:116988; Q59EN0; Q96P47; Q96RK3" "" "" "0" "0" "0.928" "1.398" "1.277" "0.792" "1.373" "1.445" "1.201" "1.481" "7.764" "17.9" "16.6" "25.0" "22.8" "14.1" "24.5" "25.8" "21.5" "26.5" "138.7" "" "" "" "" "" "" "" "" "" "" "9.5" "9.2" "14.3" "10.5" "7.7" "13.6" "15.2" "11.7" "14.8" "138.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3055099900900343627" "False" "High" "IsMasterProtein" "Q9P0M9" "Large ribosomal subunit protein bL27m OS=Homo sapiens OX=9606 GN=MRPL27 PE=1 SV=1" "0.006" "False" "2.308" "5" "1" "1" "1" "148" "16.1" "10.42" "2.42" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01016" "51264" "ENSG00000108826" "MRPL27" "B2RE14; hsa:51264; Q9P0M9" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2673167889447724756" "False" "High" "IsMasterProtein" "Q8IZD4" "mRNA-decapping enzyme 1B OS=Homo sapiens OX=9606 GN=DCP1B PE=1 SV=2" "0.006" "False" "2.304" "1" "1" "1" "1" "617" "67.7" "8.56" "2.33" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf06058, Pf16741" "196513" "ENSG00000151065; ENSG00000284850" "DCP1B" "B4DRD1; hsa:196513; Q86XH9; Q8IZD4; Q96BP8; Q96MZ8" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-942541566262454804" "False" "High" "IsMasterProtein" "Q9BRQ0" "Pygopus homolog 2 OS=Homo sapiens OX=9606 GN=PYGO2 PE=1 SV=2" "0.006" "False" "2.303" "3" "1" "1" "1" "406" "41.2" "7.28" "0.00" "1" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "nucleus" "enzyme regulator activity;other molecular function" "Pf00628" "90780" "ENSG00000163348" "PYGO2" "hsa:90780; Q8WYZ4; Q96CY2; Q9BRQ0" "1q21.1 copy number variation syndrome" "Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex" "3" "0" "1.098" "0.631" "1.099" "0.779" "0.934" "0.853" "0.763" "0.705" "0.574" "57.3" "62.9" "36.2" "63.0" "44.7" "53.6" "48.9" "43.7" "40.4" "32.9" "" "" "" "" "" "" "" "" "" "" "30.4" "34.9" "20.7" "29.0" "24.2" "29.8" "28.8" "23.9" "22.7" "32.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3644173202538667698" "False" "High" "IsMasterProtein" "Q9Y4B6" "DDB1- and CUL4-associated factor 1 OS=Homo sapiens OX=9606 GN=DCAF1 PE=1 SV=3" "0.006" "False" "2.301" "1" "1" "1" "1" "1507" "168.9" "5.06" "2.37" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "" "9730" "ENSG00000145041" "DCAF1" "hsa:9730; Q2YD74; Q8TBD9; Q9HCA1; Q9UG37; Q9Y4B6" "Hippo-Merlin signaling dysregulation" "Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "1.051" "1.137" "1.064" "1.061" "0.982" "1.141" "1.130" "1.214" "2.299" "95.3" "100.1" "108.4" "101.4" "101.1" "93.6" "108.8" "107.7" "115.7" "219.2" "" "" "" "" "" "" "" "" "" "" "50.5" "55.5" "62.1" "46.7" "54.7" "52.1" "64.0" "58.8" "64.9" "219.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "859606760973151215" "False" "High" "IsMasterProtein" "Q562F6" "Shugoshin 2 OS=Homo sapiens OX=9606 GN=SGO2 PE=1 SV=2" "0.006" "False" "2.297" "1" "1" "1" "1" "1265" "144.7" "7.91" "1.95" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "" "" "151246" "ENSG00000163535" "SGO2" "hsa:151246; Q53RR9; Q53T20; Q562F6; Q86XY4; Q8IWK2; Q8IZK1; Q8N1Q5; Q96LQ3" "Cohesin complex - Cornelia de Lange syndrome" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "0.656" "0.607" "0.708" "0.889" "0.626" "1.398" "1.417" "1.902" "1.201" "20.4" "13.4" "12.4" "14.4" "18.1" "12.7" "28.5" "28.9" "38.7" "24.5" "" "" "" "" "" "" "" "" "" "" "10.8" "7.4" "7.1" "6.6" "9.8" "7.1" "16.8" "15.8" "21.7" "24.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6773616667088229623" "False" "High" "IsMasterProtein" "Q8N4Q0" "Prostaglandin reductase 3 OS=Homo sapiens OX=9606 GN=PTGR3 PE=1 SV=1" "0.006" "False" "2.294" "2" "1" "1" "1" "377" "40.1" "8.18" "0.00" "1" "other metabolic processes;other biological processes" "other cytoplasmic organelle" "other molecular function" "Pf00107, Pf08240" "284273" "ENSG00000180011" "PTGR3" "A8KA15; B4DZ91; hsa:284273; Q8N4Q0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4790562829176069588" "False" "High" "IsMasterProtein" "Q9BV19" "Uncharacterized protein C1orf50 OS=Homo sapiens OX=9606 GN=C1orf50 PE=1 SV=2" "0.006" "False" "2.284" "4" "1" "1" "1" "199" "21.9" "5.88" "2.74" "1" "" "" "other molecular function" "Pf10504" "79078" "ENSG00000164008" "C1orf50" "Q9BV19" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3573603970106114423" "False" "High" "IsMasterProtein" "Q9H2F5" "Enhancer of polycomb homolog 1 OS=Homo sapiens OX=9606 GN=EPC1 PE=1 SV=1" "0.006" "False" "2.271" "1" "1" "1" "1" "836" "93.4" "8.59" "0.00" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf06752, Pf10513" "80314" "ENSG00000120616" "EPC1" "B4DSC3; D3DRX7; hsa:80314; Q5VW54; Q5VW56; Q5VW58; Q8NAQ4; Q8NE21; Q96LF4; Q96RR6; Q9H2F5; Q9H7T7" "" "Transcriptional Regulation by E2F6; HATs acetylate histones" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8712581138028706155" "False" "High" "IsMasterProtein" "Cont_P02081" "Hemoglobin fetal subunit beta OS=Bos taurus OX=9913 PE=1 SV=1" "0.006" "True" "2.261" "6" "1" "1" "1" "145" "15.8" "7.03" "2.11" "1" "other metabolic processes;transport;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00042" "104983812; 109569915; 109569938; 511735" "ENSBIXG00000000751; ENSBTAG00000038748" "LOC104983812; LOC109569915; LOC113905586" "A0A4W2CHH0; A0A6P3GXP4; A0A6P5D2L1; bbis:104983812; biu:109569915; biu:109569938; bta:511735; P02081; Q3SX09" "" "" "0" "0" "1.099" "0.890" "1.041" "1.262" "1.975" "1.254" "0.965" "1.162" "1.091" "64.4" "70.8" "57.3" "67.1" "81.3" "127.3" "80.8" "62.2" "74.9" "70.3" "" "" "" "" "" "" "" "" "" "" "34.1" "39.3" "32.8" "30.9" "44.0" "70.8" "47.5" "33.9" "42.0" "70.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2011789362582396358" "False" "High" "IsMasterProtein" "Q9NSI8" "SAM domain-containing protein SAMSN-1 OS=Homo sapiens OX=9606 GN=SAMSN1 PE=1 SV=1" "0.006" "False" "2.260" "2" "1" "1" "1" "373" "41.7" "5.43" "1.80" "1" "other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07647, Pf07653, Pf12485" "64092" "ENSG00000155307" "SAMSN1" "B3KWJ3; F8WAA1; hsa:64092; Q8NFF7; Q9C041; Q9NSI8" "TYROBP causal network in microglia" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5281205603675225167" "False" "High" "IsMasterProtein" "Q9NX76" "CKLF-like MARVEL transmembrane domain-containing protein 6 OS=Homo sapiens OX=9606 GN=CMTM6 PE=1 SV=1" "0.006" "False" "2.260" "5" "1" "2" "1" "183" "20.4" "5.29" "3.43" "1" "transport;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle" "" "Pf01284" "54918" "ENSG00000091317" "CMTM6" "hsa:54918; Q6IAC4; Q9NX76" "" "Neutrophil degranulation" "1" "0" "1.038" "0.936" "1.750" "1.255" "1.349" "1.089" "1.366" "1.142" "0.819" "23.5" "24.4" "22.0" "41.1" "29.5" "31.7" "25.6" "32.1" "26.8" "19.2" "" "" "" "" "" "" "" "" "" "" "12.4" "13.5" "12.6" "18.9" "15.9" "17.6" "15.0" "17.5" "15.0" "19.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1970257073034718295" "False" "High" "IsMasterProtein" "Q6RW13" "Type-1 angiotensin II receptor-associated protein OS=Homo sapiens OX=9606 GN=AGTRAP PE=1 SV=1" "0.006" "False" "2.260" "5" "1" "1" "1" "159" "17.4" "6.14" "3.00" "1" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf06396" "57085" "ENSG00000177674" "AGTRAP" "A8MVQ5; hsa:57085; Q5SNV4; Q5SNV5; Q6RW13; Q96AC0; Q96PL4; Q9NRW9" "" "Signaling by BRAF and RAF1 fusions" "1" "0" "1.145" "1.016" "1.016" "1.142" "1.106" "1.187" "1.074" "0.982" "1.138" "222.0" "254.1" "225.6" "225.6" "253.5" "245.6" "263.4" "238.3" "218.0" "252.5" "" "" "" "" "" "" "" "" "" "" "117.5" "140.9" "129.2" "103.9" "137.2" "136.6" "155.0" "130.1" "122.3" "252.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5664998384620828706" "False" "High" "IsMasterProtein" "Q13895" "Bystin OS=Homo sapiens OX=9606 GN=BYSL PE=1 SV=3" "0.006" "False" "2.258" "2" "1" "1" "1" "437" "49.6" "8.12" "1.87" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05291" "705" "ENSG00000112578" "BYSL" "hsa:705; Q13895; Q6P5W4; Q86W44; Q96IP8" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.027" "0.886" "1.415" "0.851" "0.816" "1.001" "0.922" "0.981" "1.311" "45.1" "46.3" "40.0" "63.8" "38.4" "36.8" "45.1" "41.6" "44.2" "59.1" "" "" "" "" "" "" "" "" "" "" "23.9" "25.7" "22.9" "29.4" "20.8" "20.5" "26.6" "22.7" "24.8" "59.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2107690767117566608" "False" "High" "IsMasterProtein" "P04150" "Glucocorticoid receptor OS=Homo sapiens OX=9606 GN=NR3C1 PE=1 SV=1" "0.006" "False" "2.255" "1" "1" "1" "1" "777" "85.6" "6.38" "2.48" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105, Pf02155" "2908" "ENSG00000113580" "NR3C1" "A0ZXF9; B0LPG8; D3DQF4; F5ATB7; hsa:2908; P04150; P04151; Q53EP5; Q6N0A4" "Nuclear receptors; Adipogenesis; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Endoderm differentiation; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; White fat cell differentiation; Vitamin D in inflammatory diseases; 16p11.2 proximal deletion syndrome; HDAC6 interactions in the central nervous system; Sudden infant death syndrome (SIDS) susceptibility pathways; Serotonin receptor 4/6/7 and NR3C signaling" "Potential therapeutics for SARS; Regulation of RUNX2 expression and activity; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Circadian Clock; SUMOylation of intracellular receptors; PTK6 Expression; Regulation of NPAS4 gene transcription" "21" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8995657341512938219" "False" "High" "IsMasterProtein" "P47914" "Large ribosomal subunit protein eL29 OS=Homo sapiens OX=9606 GN=RPL29 PE=1 SV=2" "0.006" "False" "2.250" "5" "1" "1" "1" "159" "17.7" "11.66" "2.24" "1" "protein metabolism;other metabolic processes;developmental processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01779" "6159" "ENSG00000162244" "RPL29" "A8K0H3; B2R4M8; hsa:6159; P47914; Q6IPY3" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9192957103143993371" "False" "High" "IsMasterProtein" "Cont_Q9TTE1" "Serpin A3-1 OS=Bos taurus OX=9913 GN=SERPINA3-1 PE=1 SV=3" "0.006" "True" "2.248" "2" "1" "1" "1" "411" "46.2" "5.99" "1.81" "1" "" "non-structural extracellular;other cell component" "enzyme regulator activity" "Pf00079" "286804" "" "SERPINA3-1" "bta:286804; Q2KIQ9; Q3ZEJ7; Q9TTE1" "" "" "0" "0" "0.902" "1.016" "0.841" "1.132" "1.143" "0.912" "1.120" "1.027" "0.566" "300.4" "271.0" "305.4" "252.5" "340.2" "343.4" "273.9" "336.6" "308.7" "169.9" "" "" "" "" "" "" "" "" "" "" "159.1" "150.3" "174.9" "116.3" "184.0" "191.0" "161.2" "183.7" "173.2" "169.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6228343932262831473" "False" "High" "IsMasterProtein" "O43159" "Ribosomal RNA-processing protein 8 OS=Homo sapiens OX=9606 GN=RRP8 PE=1 SV=2" "0.006" "False" "2.247" "2" "1" "1" "1" "456" "50.7" "9.42" "2.56" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf05148" "23378" "ENSG00000132275" "RRP8" "hsa:23378; O43159; Q7KZ78; Q9BVM6" "" "SIRT1 negatively regulates rRNA expression" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5100891898626735389" "False" "High" "IsMasterProtein" "Q86WA6" "Valacyclovir hydrolase OS=Homo sapiens OX=9606 GN=BPHL PE=1 SV=1" "0.006" "False" "2.247" "2" "1" "1" "1" "291" "32.5" "9.14" "2.72" "1" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00561" "670" "ENSG00000137274" "BPHL" "hsa:670; Q00306; Q13855; Q3KP51; Q86WA6" "" "Phase I - Functionalization of compounds" "1" "0" "0.975" "0.997" "0.926" "1.008" "1.050" "0.873" "0.953" "0.865" "0.590" "296.6" "289.2" "295.8" "274.7" "298.9" "311.6" "258.8" "282.6" "256.6" "174.9" "" "" "" "" "" "" "" "" "" "" "157.1" "160.3" "169.4" "126.5" "161.7" "173.3" "152.3" "154.3" "143.9" "174.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6755296670490160775" "False" "High" "IsMasterProtein" "Q96SB3" "Neurabin-2 OS=Homo sapiens OX=9606 GN=PPP1R9B PE=1 SV=3" "0.006" "False" "2.247" "1" "1" "1" "1" "817" "89.3" "4.97" "0.00" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00595, Pf17817" "84687" "ENSG00000108819" "PPP1R9B" "D3DTX6; hsa:84687; Q8TCR9; Q96SB3" "" "" "0" "0" "1.450" "0.833" "1.351" "1.758" "1.004" "1.619" "1.202" "1.468" "1.015" "13.7" "19.9" "11.4" "18.6" "24.1" "13.8" "22.2" "16.5" "20.2" "13.9" "" "" "" "" "" "" "" "" "" "" "7.3" "11.0" "6.6" "8.5" "13.1" "7.7" "13.1" "9.0" "11.3" "13.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-560084501499272066" "False" "High" "IsMasterProtein" "Q8IY18" "Structural maintenance of chromosomes protein 5 OS=Homo sapiens OX=9606 GN=SMC5 PE=1 SV=2" "0.006" "False" "2.245" "1" "1" "1" "1" "1101" "128.7" "8.38" "2.05" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463" "23137" "ENSG00000198887" "SMC5" "A6NM81; hsa:23137; O60335; Q05D92; Q5VZ60; Q8IY18; Q96SB9" "" "SUMOylation of DNA damage response and repair proteins" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5541205227018029514" "False" "High" "IsMasterProtein" "Q9H0P0" "Cytosolic 5'-nucleotidase 3A OS=Homo sapiens OX=9606 GN=NT5C3A PE=1 SV=3" "0.006" "False" "2.245" "2" "1" "1" "1" "336" "37.9" "7.12" "2.92" "1" "other metabolic processes;stress response" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf05822" "51251" "ENSG00000122643" "NT5C3A" "A8K253; B2RAA5; B8ZZC4; hsa:51251; Q6IPZ1; Q6NXS6; Q7L3G6; Q9H0P0; Q9P0P5; Q9UC42; Q9UC43; Q9UC44; Q9UC45" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4320196251115137643" "False" "High" "IsMasterProtein" "O43405" "Cochlin OS=Homo sapiens OX=9606 GN=COCH PE=1 SV=1" "0.006" "False" "2.244" "2" "1" "1" "1" "550" "59.4" "7.96" "1.68" "1" "other biological processes" "non-structural extracellular;extracellular matrix" "other molecular function" "Pf00092, Pf03815" "1690" "ENSG00000100473" "COCH" "A8K9K9; D3DS84; hsa:1690; O43405; Q96IU6" "" "" "0" "0" "0.956" "0.976" "1.052" "1.018" "0.888" "1.024" "0.928" "1.055" "0.988" "91.5" "87.5" "89.3" "96.3" "93.2" "81.3" "93.7" "84.9" "96.6" "90.4" "" "" "" "" "" "" "" "" "" "" "48.5" "48.5" "51.2" "44.4" "50.4" "45.2" "55.2" "46.3" "54.2" "90.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3413891887359958114" "False" "High" "IsMasterProtein" "Q9BQC6" "Large ribosomal subunit protein mL63 OS=Homo sapiens OX=9606 GN=MRPL57 PE=1 SV=1" "0.007" "False" "2.224" "7" "1" "1" "1" "102" "12.3" "11.44" "3.07" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf14978" "78988" "ENSG00000173141" "MRPL57" "A2A332; hsa:78988; Q9BQC6" "" "Mitochondrial translation elongation; Mitochondrial translation initiation; Mitochondrial translation termination" "3" "0" "1.009" "0.936" "0.914" "0.994" "1.011" "0.743" "0.594" "0.815" "1.597" "313.1" "315.9" "293.0" "286.2" "311.3" "316.5" "232.7" "186.0" "255.2" "500.0" "" "" "" "" "" "" "" "" "" "" "165.8" "175.2" "167.8" "131.8" "168.4" "176.1" "136.9" "101.5" "143.2" "500.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5766769550040713609" "False" "High" "IsMasterProtein" "Q9UHI6" "Probable ATP-dependent RNA helicase DDX20 OS=Homo sapiens OX=9606 GN=DDX20 PE=1 SV=2" "0.007" "False" "2.222" "1" "1" "1" "1" "824" "92.2" "6.95" "2.22" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "11218" "ENSG00000064703" "DDX20" "B4DWV7; hsa:11218; Q96F72; Q9NVM3; Q9UF59; Q9UHI6; Q9UIY0; Q9Y659" "mRNA processing; Male infertility" "SARS-CoV-2 modulates host translation machinery; snRNP Assembly" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2088218542987526353" "False" "High" "IsMasterProtein" "P49005" "DNA polymerase delta subunit 2 OS=Homo sapiens OX=9606 GN=POLD2 PE=1 SV=1" "0.007" "False" "2.219" "1" "1" "1" "1" "469" "51.3" "5.58" "2.35" "1" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity" "Pf04042, Pf18018" "5425" "ENSG00000106628" "POLD2" "A4D2J4; B2R5S4; hsa:5425; P49005" "Homologous recombination; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Polymerase switching on the C-strand of the telomere; Polymerase switching" "25" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5532821643516687408" "False" "High" "IsMasterProtein" "Q6P158" "Putative ATP-dependent RNA helicase DHX57 OS=Homo sapiens OX=9606 GN=DHX57 PE=1 SV=2" "0.007" "False" "2.217" "1" "1" "1" "1" "1386" "155.5" "7.71" "2.19" "1" "" "" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf05773, Pf07717, Pf18044, Pf21010" "90957" "ENSG00000163214" "DHX57" "A2RRC7; hsa:90957; Q53SI4; Q6P158; Q6P9G1; Q7Z6H3; Q8NG17; Q96M33" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8657870357206849576" "False" "High" "IsMasterProtein" "Q9Y2Y0" "ADP-ribosylation factor-like protein 2-binding protein OS=Homo sapiens OX=9606 GN=ARL2BP PE=1 SV=1" "0.007" "False" "2.216" "7" "1" "1" "1" "163" "18.8" "4.35" "1.95" "1" "signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf11527" "23568" "ENSG00000102931" "ARL2BP" "B3KQJ5; hsa:23568; Q504R0; Q9Y2Y0" "Ciliopathies" "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane" "2" "0" "0.626" "0.839" "0.952" "0.913" "0.707" "0.925" "0.861" "0.899" "1.523" "52.0" "32.6" "43.7" "49.5" "47.5" "36.8" "48.1" "44.8" "46.7" "79.2" "" "" "" "" "" "" "" "" "" "" "27.5" "18.1" "25.0" "22.8" "25.7" "20.5" "28.3" "24.4" "26.2" "79.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2016868097673482949" "False" "High" "IsMasterProtein" "Q9GZY6" "Linker for activation of T-cells family member 2 OS=Homo sapiens OX=9606 GN=LAT2 PE=1 SV=1" "0.007" "False" "2.214" "6" "1" "1" "1" "243" "26.5" "4.78" "0.00" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf15703" "7462" "ENSG00000086730" "LAT2" "A6NFK6; A8K209; A8K4F1; D3DXF9; hsa:7462; Q9BXX8; Q9GZY6; Q9NZY9" "B cell receptor signaling pathway; 7q11.23 copy number variation syndrome" "Role of LAT2/NTAL/LAB on calcium mobilization" "3" "0" "1.337" "1.062" "1.707" "1.647" "1.449" "1.044" "1.024" "0.824" "0.773" "16.1" "21.5" "17.1" "27.4" "26.4" "23.3" "16.8" "16.4" "13.2" "12.4" "" "" "" "" "" "" "" "" "" "" "8.5" "11.9" "9.8" "12.6" "14.3" "12.9" "9.9" "9.0" "7.4" "12.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1654443810418690353" "False" "High" "IsMasterProtein" "Q9UJU2" "Lymphoid enhancer-binding factor 1 OS=Homo sapiens OX=9606 GN=LEF1 PE=1 SV=1" "0.008" "False" "2.204" "3" "1" "1" "1" "399" "44.2" "7.42" "1.79" "1" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf08347" "51176" "ENSG00000138795" "LEF1" "B4DG38; B7Z8E2; E9PDK3; hsa:51176; Q3ZCU4; Q9HAZ0; Q9UJU2" "Arrhythmogenic right ventricular cardiomyopathy; Endoderm differentiation; Mesodermal commitment pathway; Mesodermal commitment pathway; Wnt signaling pathway; Hepatitis C and hepatocellular carcinoma; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Amplification and expansion of oncogenic pathways as metastatic traits; Canonical and non-canonical Notch signaling; Wnt signaling pathway and pluripotency; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; Effect of progerin on genes involved in progeria; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Hippo signaling regulation pathways; TGF-beta receptor signaling in skeletal dysplasias; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Acute myeloid leukemia; 11p11.2 copy number variation syndrome ; Cell lineage map for neuronal differentiation; TGF-beta receptor signaling; DNA damage response (only ATM dependent)" "Formation of paraxial mesoderm; Transcriptional Regulation by VENTX; Ca2+ pathway; Transcriptional regulation of granulopoiesis; Somitogenesis; Formation of axial mesoderm; Deactivation of the beta-catenin transactivating complex; Cardiogenesis; Germ layer formation at gastrulation; Binding of TCF/LEF:CTNNB1 to target gene promoters; RUNX3 regulates WNT signaling; Repression of WNT target genes" "41" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2132288438487461579" "False" "High" "IsMasterProtein" "Q9BV68" "E3 ubiquitin-protein ligase RNF126 OS=Homo sapiens OX=9606 GN=RNF126 PE=1 SV=2" "0.008" "False" "2.203" "3" "1" "1" "1" "311" "33.8" "5.47" "2.99" "1" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf13639, Pf14369" "55658" "ENSG00000070423" "RNF126" "hsa:55658; Q9BV68; Q9NWX1" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.933" "1.194" "1.003" "1.017" "0.993" "0.893" "0.942" "1.057" "1.378" "193.5" "180.5" "231.1" "194.1" "196.8" "192.2" "172.8" "182.2" "204.5" "266.6" "" "" "" "" "" "" "" "" "" "" "102.4" "100.1" "132.3" "89.4" "106.5" "106.9" "101.7" "99.4" "114.7" "266.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1867390860608568122" "False" "High" "IsMasterProtein" "Q9BRJ2" "Large ribosomal subunit protein mL45 OS=Homo sapiens OX=9606 GN=MRPL45 PE=1 SV=2" "0.008" "False" "2.202" "3" "1" "1" "1" "306" "35.3" "9.03" "2.55" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf04280" "" "ENSG00000277936" "MRPL45" "A1L436; Q6ZMJ5; Q9BRJ2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2552145293122951673" "False" "High" "IsMasterProtein" "Q96P48" "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ARAP1 PE=1 SV=3" "0.008" "False" "2.200" "1" "1" "1" "1" "1450" "162.1" "6.23" "2.42" "1" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00169, Pf00536, Pf00620, Pf00788, Pf01412" "116985" "ENSG00000186635" "ARAP1" "A3KLL7; B2RTS2; hsa:116985; O94879; Q4LDD5; Q59FI7; Q6PHS3; Q8WU51; Q96HP6; Q96L71; Q96P48" "" "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; RHOA GTPase cycle; RAC1 GTPase cycle; CDC42 GTPase cycle" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6535864909566568035" "False" "High" "IsMasterProtein" "O75367" "Core histone macro-H2A.1 OS=Homo sapiens OX=9606 GN=MACROH2A1 PE=1 SV=5" "0.008" "False" "2.198" "2" "1" "1" "1" "369" "39.2" "9.83" "2.50" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00125, Pf01661, Pf16211" "9555" "ENSG00000113648" "MACROH2A1" "hsa:9555; O75367; O75377; Q503A8; Q7Z5E3; Q96D41; Q9H8P3; Q9UP96" "H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma" "" "2" "0" "1.118" "1.057" "1.529" "1.212" "1.170" "1.581" "1.680" "1.648" "1.001" "71.0" "79.4" "75.1" "108.6" "86.1" "83.1" "112.3" "119.3" "117.0" "71.1" "" "" "" "" "" "" "" "" "" "" "37.6" "44.0" "43.0" "50.0" "46.6" "46.2" "66.1" "65.1" "65.7" "71.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1354238916064112101" "False" "High" "IsMasterProtein" "Q5T6V5" "Queuosine 5'-phosphate N-glycosylase/hydrolase OS=Homo sapiens OX=9606 GN=QNG1 PE=1 SV=1" "0.008" "False" "2.196" "2" "1" "1" "1" "341" "39.0" "5.88" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf10343" "84267" "ENSG00000165118" "QNG1" "B2RPI6; hsa:84267; Q5T6V5; Q8N2B1; Q9BT18" "" "" "0" "0" "1.133" "1.085" "1.304" "1.083" "0.999" "1.083" "1.202" "1.171" "0.835" "34.5" "39.1" "37.5" "45.0" "37.4" "34.5" "37.4" "41.5" "40.4" "28.8" "" "" "" "" "" "" "" "" "" "" "18.3" "21.7" "21.5" "20.7" "20.2" "19.2" "22.0" "22.7" "22.7" "28.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1131809670189224217" "False" "High" "IsMasterProtein" "Q96EY7" "Small ribosomal subunit protein mS39 OS=Homo sapiens OX=9606 GN=PTCD3 PE=1 SV=3" "0.008" "False" "2.195" "1" "1" "1" "1" "689" "78.5" "6.42" "2.79" "1" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;translational apparatus;nucleus" "translation activity;nucleic acid binding activity" "Pf13041, Pf13812" "55037" "ENSG00000132300" "PTCD3" "A6NHD2; D6W5M1; hsa:55037; Q597H0; Q658Y9; Q96EY7; Q9BUZ8; Q9NWL0" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.015" "1.005" "1.190" "1.065" "1.194" "1.161" "0.544" "1.223" "7.059" "62.2" "63.1" "62.5" "74.0" "66.2" "74.3" "72.2" "33.9" "76.1" "439.1" "" "" "" "" "" "" "" "" "" "" "32.9" "35.0" "35.8" "34.1" "35.8" "41.3" "42.5" "18.5" "42.7" "439.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2504769513394967935" "False" "High" "IsMasterProtein" "Q2QD12" "Ribulose-phosphate 3-epimerase-like protein 1 OS=Homo sapiens OX=9606 GN=RPEL1 PE=1 SV=1" "0.008" "False" "2.193" "3" "1" "1" "1" "228" "25.0" "5.41" "2.46" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf00834" "729020" "ENSG00000235376" "RPEL1" "hsa:729020; Q2QD12" "" "Pentose phosphate pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3198334949532979984" "False" "High" "IsMasterProtein" "P59044" "NACHT, LRR and PYD domains-containing protein 6 OS=Homo sapiens OX=9606 GN=NLRP6 PE=1 SV=2" "0.008" "False" "2.189" "1" "1" "1" "1" "892" "98.7" "8.07" "1.77" "1" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02758, Pf05729, Pf17776, Pf17779" "171389" "ENSG00000174885" "NLRP6" "A8K9F3; E9PJZ8; hsa:171389; P59044" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1039110044047390579" "False" "High" "IsMasterProtein" "Q15170" "Transcription elongation factor A protein-like 1 OS=Homo sapiens OX=9606 GN=TCEAL1 PE=1 SV=3" "0.008" "False" "2.188" "4" "1" "1" "1" "159" "18.6" "5.02" "3.00" "1" "" "nucleus" "" "Pf04538" "9338" "ENSG00000172465" "TCEAL1" "hsa:9338; Q15170; Q9UJQ9" "" "" "0" "0" "0.847" "0.927" "0.957" "0.864" "0.837" "0.850" "0.847" "0.869" "0.591" "480.6" "407.3" "445.5" "459.9" "415.1" "402.4" "408.4" "407.2" "417.6" "284.2" "" "" "" "" "" "" "" "" "" "" "254.5" "225.8" "255.2" "211.8" "224.6" "223.8" "240.4" "222.3" "234.3" "284.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1383299506835269053" "False" "High" "IsMasterProtein" "Q9HCJ6" "Synaptic vesicle membrane protein VAT-1 homolog-like OS=Homo sapiens OX=9606 GN=VAT1L PE=1 SV=2" "0.008" "False" "2.188" "3" "1" "1" "1" "419" "45.9" "5.06" "0.00" "1" "" "" "other molecular function" "Pf08240, Pf13602" "57687" "ENSG00000171724" "VAT1L" "hsa:57687; Q8IYW8; Q9HCJ6" "" "" "0" "0" "1.194" "1.411" "1.265" "0.839" "1.054" "0.931" "1.010" "0.720" "0.680" "18.9" "22.5" "26.6" "23.9" "15.8" "19.9" "17.6" "19.1" "13.6" "12.8" "" "" "" "" "" "" "" "" "" "" "10.0" "12.5" "15.2" "11.0" "8.6" "11.1" "10.3" "10.4" "7.6" "12.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2029862218257081345" "False" "High" "IsMasterProtein" "O15318" "DNA-directed RNA polymerase III subunit RPC7 OS=Homo sapiens OX=9606 GN=POLR3G PE=1 SV=2" "0.008" "False" "2.186" "5" "1" "1" "1" "223" "25.9" "4.63" "2.63" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "other molecular function" "Pf11705" "10622" "ENSG00000113356" "POLR3G" "A8MTH0; hsa:10622; O15318" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; TAR syndrome" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "10" "0" "1.451" "1.131" "1.479" "1.381" "1.100" "1.185" "1.016" "1.370" "1.193" "67.6" "98.1" "76.5" "100.0" "93.4" "74.4" "80.2" "68.7" "92.6" "80.7" "" "" "" "" "" "" "" "" "" "" "35.8" "54.4" "43.8" "46.1" "50.5" "41.4" "47.2" "37.5" "52.0" "80.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7369433181564394735" "False" "High" "IsMasterProtein" "P08708" "Small ribosomal subunit protein eS17 OS=Homo sapiens OX=9606 GN=RPS17 PE=1 SV=2" "0.008" "False" "2.183" "6" "1" "1" "1" "135" "15.5" "9.85" "2.31" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00833" "6218" "ENSG00000182774; ENSG00000278229" "RPS17" "B2R4U4; hsa:6218; P08708; P0CW22" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2106052778808331693" "False" "High" "IsMasterProtein" "P62910" "Large ribosomal subunit protein eL32 OS=Homo sapiens OX=9606 GN=RPL32 PE=1 SV=2" "0.008" "False" "2.183" "5" "1" "1" "1" "135" "15.9" "11.33" "2.91" "1" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01655" "6161" "ENSG00000144713" "RPL32" "B2R4Q3; hsa:6161; P02433; P62910" "Cytoplasmic ribosomal proteins" "Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.933" "0.930" "1.152" "1.008" "1.049" "1.029" "0.914" "0.903" "0.595" "159.5" "148.9" "148.4" "183.7" "160.9" "167.4" "164.2" "145.8" "144.0" "95.0" "" "" "" "" "" "" "" "" "" "" "84.5" "82.6" "85.0" "84.6" "87.0" "93.1" "96.6" "79.6" "80.8" "95.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5978102986579792947" "False" "High" "IsMasterProtein" "Q69YL0" "Protein NCBP2AS2 OS=Homo sapiens OX=9606 GN=NCBP2AS2 PE=1 SV=1" "0.008" "False" "2.180" "8" "1" "1" "1" "99" "10.9" "12.00" "2.24" "1" "" "" "" "" "" "ENSG00000270170" "NCBP2AS2" "Q69YL0" "3q29 copy number variation syndrome" "" "1" "0" "1.054" "1.034" "1.099" "1.135" "0.965" "0.930" "0.841" "0.963" "0.898" "86.7" "91.4" "89.7" "95.2" "98.4" "83.6" "80.6" "72.9" "83.5" "77.8" "" "" "" "" "" "" "" "" "" "" "45.9" "50.7" "51.4" "43.9" "53.2" "46.5" "47.5" "39.8" "46.9" "77.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2149131157478544716" "False" "High" "IsMasterProtein" "Q6P587" "Oxaloacetate tautomerase FAHD1, mitochondrial OS=Homo sapiens OX=9606 GN=FAHD1 PE=1 SV=3" "0.008" "False" "2.179" "3" "1" "1" "1" "221" "24.5" "7.39" "2.78" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "0.873" "1.453" "1.830" "1.527" "1.570" "1.501" "1.210" "1.331" "0.744" "71.2" "62.1" "103.4" "130.2" "108.7" "111.7" "106.8" "86.1" "94.7" "52.9" "" "" "" "" "" "" "" "" "" "" "37.7" "34.4" "59.2" "60.0" "58.8" "62.1" "62.8" "47.0" "53.1" "52.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7635739719901529146" "False" "High" "IsMasterProtein" "Q8TB03" "Uncharacterized protein CXorf38 OS=Homo sapiens OX=9606 GN=CXorf38 PE=1 SV=1" "0.008" "False" "2.178" "3" "1" "1" "1" "319" "36.6" "6.30" "2.78" "1" "" "" "" "Pf15112" "159013" "ENSG00000185753" "CXorf38" "B3KW28; D3DWB5; hsa:159013; Q5JPF5; Q8N941; Q8TB03" "" "" "0" "0" "1.267" "1.051" "1.142" "1.175" "1.131" "1.256" "1.164" "1.205" "0.907" "181.8" "230.3" "191.1" "207.6" "213.6" "205.7" "228.3" "211.7" "219.1" "164.9" "" "" "" "" "" "" "" "" "" "" "96.3" "127.7" "109.4" "95.6" "115.5" "114.4" "134.4" "115.6" "122.9" "164.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6067622255201761803" "False" "High" "IsMasterProtein" "O95059" "Ribonuclease P protein subunit p14 OS=Homo sapiens OX=9606 GN=RPP14 PE=1 SV=3" "0.008" "False" "2.173" "6" "1" "2" "1" "124" "13.7" "7.75" "4.35" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01900" "11102" "ENSG00000163684" "RPP14" "O95059; Q53X97" "" "tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol" "2" "0" "1.109" "1.120" "1.477" "1.006" "1.301" "1.397" "1.229" "1.192" "0.926" "51.2" "56.8" "57.3" "75.6" "51.5" "66.6" "71.5" "62.9" "61.0" "47.4" "" "" "" "" "" "" "" "" "" "" "27.1" "31.5" "32.8" "34.8" "27.8" "37.0" "42.1" "34.3" "34.2" "47.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6814802731580382634" "False" "High" "IsMasterProtein" "Q6SJ96" "TATA box-binding protein-like 2 OS=Homo sapiens OX=9606 GN=TBPL2 PE=2 SV=2" "0.008" "False" "2.172" "2" "1" "1" "1" "343" "38.0" "5.74" "2.63" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00352" "387332" "ENSG00000182521" "TBPL2" "hsa:387332; Q17RU8; Q6SJ96" "" "Germ layer formation at gastrulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3159799509992601123" "False" "High" "IsMasterProtein" "Q96FK6" "WD repeat-containing protein 89 OS=Homo sapiens OX=9606 GN=WDR89 PE=1 SV=1" "0.008" "False" "2.171" "2" "1" "1" "1" "387" "43.2" "6.13" "2.85" "1" "developmental processes" "" "" "Pf00400" "112840" "ENSG00000140006" "WDR89" "hsa:112840; Q96FK6" "" "" "0" "0" "1.017" "1.008" "1.126" "1.086" "1.072" "1.207" "1.163" "1.097" "0.372" "199.9" "203.3" "201.5" "225.1" "217.1" "214.2" "241.3" "232.5" "219.2" "74.3" "" "" "" "" "" "" "" "" "" "" "105.8" "112.7" "115.4" "103.7" "117.4" "119.2" "142.0" "126.9" "123.0" "74.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7917759671781486439" "False" "High" "IsMasterProtein" "Q13627" "Dual specificity tyrosine-phosphorylation-regulated kinase 1A OS=Homo sapiens OX=9606 GN=DYRK1A PE=1 SV=2" "0.008" "False" "2.163" "1" "1" "1" "1" "763" "85.5" "8.75" "2.38" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "1859" "ENSG00000157540" "DYRK1A" "hsa:1859; O60769; Q13627; Q92582; Q92810; Q9UNM5" "T cell receptor and co-stimulatory signaling; DYRK1A involvement regarding cell proliferation in brain development" "G0 and Early G1" "3" "0" "1.044" "0.965" "0.975" "0.972" "0.969" "0.959" "0.807" "0.827" "0.855" "173.2" "180.9" "167.1" "168.8" "168.3" "167.9" "166.0" "139.8" "143.3" "148.0" "" "" "" "" "" "" "" "" "" "" "91.7" "100.3" "95.7" "77.7" "91.0" "93.4" "97.7" "76.3" "80.4" "148.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5875685193594640149" "False" "High" "IsMasterProtein" "Q7Z3U7" "Protein MON2 homolog OS=Homo sapiens OX=9606 GN=MON2 PE=1 SV=3" "0.008" "False" "2.159" "0" "1" "1" "1" "1717" "190.2" "6.06" "0.00" "1" "transport" "other membranes;cytosol;other cytoplasmic organelle" "" "Pf09324, Pf12783, Pf16206, Pf16213" "23041" "ENSG00000061987" "MON2" "A5D8U7; A7E2Y0; B9EGP5; F8VWA6; F8W1Z6; hsa:23041; Q7Z3U7; Q86TA2; Q8N3I5; Q8NAI0; Q8NHE2; Q9UPW1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4687575668731336676" "False" "High" "IsMasterProtein" "Q6UX04" "Spliceosome-associated protein CWC27 homolog OS=Homo sapiens OX=9606 GN=CWC27 PE=1 SV=1" "0.009" "False" "2.150" "1" "1" "1" "1" "472" "53.8" "5.80" "2.44" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00160" "10283" "ENSG00000153015" "CWC27" "hsa:10283; O60529; O60530; Q6UX04; Q96EM3" "" "mRNA Splicing - Major Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2213964009562645664" "False" "High" "IsMasterProtein" "Q9Y221" "60S ribosome subunit biogenesis protein NIP7 homolog OS=Homo sapiens OX=9606 GN=NIP7 PE=1 SV=1" "0.009" "False" "2.148" "6" "1" "1" "1" "180" "20.4" "8.51" "2.24" "1" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "" "Pf03657, Pf17833" "51388" "ENSG00000132603" "NIP7" "B2RD04; hsa:51388; Q9NZZ0; Q9Y221" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "407233124236787373" "False" "High" "IsMasterProtein" "Q96DB5" "Regulator of microtubule dynamics protein 1 OS=Homo sapiens OX=9606 GN=RMDN1 PE=1 SV=1" "0.009" "False" "2.147" "4" "1" "1" "1" "314" "35.8" "8.50" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity" "Pf21033" "51115" "ENSG00000176623" "RMDN1" "A9UMZ8; B4DNF5; B4DZW6; B5MC61; C9JSC6; E7EVI2; hsa:51115; Q96DB5; Q9Y398" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3472169871785604282" "False" "High" "IsMasterProtein" "P61009" "Signal peptidase complex subunit 3 OS=Homo sapiens OX=9606 GN=SPCS3 PE=1 SV=1" "0.009" "False" "2.147" "5" "1" "1" "1" "180" "20.3" "8.62" "1.89" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi" "" "Pf04573" "60559" "ENSG00000129128" "SPCS3" "hsa:60559; P12280; P61009; Q9H0S7" "15q25 copy number variation" "SRP-dependent cotranslational protein targeting to membrane; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP); Maturation of hRSV A proteins; Synthesis, secretion, and deacylation of Ghrelin" "6" "0" "1.205" "1.263" "1.255" "1.335" "1.222" "1.170" "1.108" "1.152" "1.519" "118.6" "142.9" "149.8" "148.9" "158.3" "144.9" "138.7" "131.4" "136.6" "180.2" "" "" "" "" "" "" "" "" "" "" "62.8" "79.2" "85.8" "68.6" "85.7" "80.6" "81.6" "71.7" "76.6" "180.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5800402154155294758" "False" "High" "IsMasterProtein" "Q8N300" "Small vasohibin-binding protein OS=Homo sapiens OX=9606 GN=SVBP PE=1 SV=1" "0.009" "False" "2.141" "11" "1" "1" "1" "66" "7.8" "9.16" "2.97" "1" "cell organization and biogenesis;protein metabolism;transport;developmental processes;other biological processes" "non-structural extracellular;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity" "Pf15674" "374969" "ENSG00000177868" "SVBP" "A8K5P1; D3DPW7; hsa:374969; Q8N300" "" "Carboxyterminal post-translational modifications of tubulin" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6960359147395003723" "False" "High" "IsMasterProtein" "P15498" "Proto-oncogene vav OS=Homo sapiens OX=9606 GN=VAV1 PE=1 SV=4" "0.009" "False" "2.140" "1" "1" "1" "1" "845" "98.3" "6.62" "1.69" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00017, Pf00018, Pf00130, Pf00169, Pf00307, Pf00621" "7409" "ENSG00000141968" "VAV1" "B4DVK9; hsa:7409; M0QXX6; P15498; Q15860" "Prolactin signaling pathway; B cell receptor signaling pathway; Hematopoietic stem cell differentiation; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL6 signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; EGF/EGFR signaling pathway; Modulators of TCR signaling and T cell activation; Regulation of actin cytoskeleton; Interferon type I signaling pathways; T-cell receptor signaling pathway" "Potential therapeutics for SARS; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated phagocytosis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; RHOA GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; RAC2 GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of signaling by CBL; GPVI-mediated activation cascade; Signaling by SCF-KIT; Azathioprine ADME; VEGFR2 mediated vascular permeability; Erythropoietin activates RAS; CD28 dependent Vav1 pathway" "38" "0" "1.073" "0.996" "1.333" "0.851" "1.174" "0.895" "0.738" "1.078" "10.119" "29.1" "31.2" "29.0" "38.8" "24.8" "34.2" "26.0" "21.5" "31.4" "294.4" "" "" "" "" "" "" "" "" "" "" "15.4" "17.3" "16.6" "17.9" "13.4" "19.0" "15.3" "11.7" "17.6" "294.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2608297445267441955" "False" "High" "IsMasterProtein" "Q96QR8" "Transcriptional regulator protein Pur-beta OS=Homo sapiens OX=9606 GN=PURB PE=1 SV=3" "0.009" "False" "2.136" "2" "1" "1" "1" "312" "33.2" "5.43" "2.85" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf04845" "5814" "ENSG00000146676" "PURB" "A4D2L7; hsa:5814; Q96QR8" "" "" "0" "0" "1.157" "1.051" "1.043" "1.050" "0.999" "0.953" "1.051" "0.993" "0.667" "249.4" "288.5" "262.1" "260.1" "261.9" "249.3" "237.6" "262.2" "247.7" "166.5" "" "" "" "" "" "" "" "" "" "" "132.1" "160.0" "150.1" "119.8" "141.7" "138.6" "139.8" "143.1" "138.9" "166.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "776622353869952197" "False" "High" "IsMasterProtein" "O60262" "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 OS=Homo sapiens OX=9606 GN=GNG7 PE=1 SV=1" "0.009" "False" "2.132" "10" "1" "1" "1" "68" "7.5" "8.51" "2.63" "1" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00631" "2788" "ENSG00000176533" "GNG7" "B2R496; hsa:2788; O60262" "Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells" "G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation" "35" "0" "1.099" "1.005" "0.966" "1.061" "0.895" "0.988" "0.992" "1.043" "0.503" "125.4" "137.9" "126.0" "121.1" "133.0" "112.3" "123.9" "124.4" "130.8" "63.1" "" "" "" "" "" "" "" "" "" "" "66.4" "76.4" "72.2" "55.8" "72.0" "62.5" "72.9" "67.9" "73.4" "63.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8286175184294444153" "False" "High" "IsMasterProtein" "A0AAG2TVC3" "Uncharacterized protein OS=Homo sapiens OX=9606 PE=4 SV=1" "0.009" "False" "2.130" "5" "1" "1" "1" "264" "28.0" "4.67" "3.21" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "0.879" "1.045" "0.955" "1.051" "0.962" "1.136" "1.134" "1.215" "1.005" "66.6" "58.6" "69.6" "63.6" "70.1" "64.1" "75.7" "75.5" "80.9" "67.0" "" "" "" "" "" "" "" "" "" "" "35.3" "32.5" "39.9" "29.3" "37.9" "35.6" "44.6" "41.2" "45.4" "67.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3289873417268458662" "False" "High" "IsMasterProtein" "Q9NX40" "OCIA domain-containing protein 1 OS=Homo sapiens OX=9606 GN=OCIAD1 PE=1 SV=1" "0.009" "False" "2.130" "3" "1" "1" "1" "245" "27.6" "7.49" "3.11" "1" "transport;other biological processes" "ER/Golgi;other cytoplasmic organelle" "" "Pf07051" "54940" "ENSG00000109180" "OCIAD1" "C9K030; G8JLN7; hsa:54940; Q9BZE8; Q9NX40" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6548984541792378367" "False" "High" "IsMasterProtein" "Q9Y5Y2" "Cytosolic Fe-S cluster assembly factor NUBP2 OS=Homo sapiens OX=9606 GN=NUBP2 PE=1 SV=1" "0.010" "False" "2.121" "4" "1" "2" "1" "271" "28.8" "5.83" "3.68" "1" "cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10609" "10101" "ENSG00000095906" "NUBP2" "D3DU80; hsa:10101; Q9NWB2; Q9Y5Y2" "Iron-sulfur cluster biogenesis" "Cytosolic iron-sulfur cluster assembly" "2" "0" "1.009" "1.081" "1.402" "1.211" "1.172" "1.108" "1.076" "0.927" "0.807" "52.9" "53.3" "57.2" "74.1" "64.0" "61.9" "58.5" "56.9" "49.0" "42.6" "" "" "" "" "" "" "" "" "" "" "28.0" "29.6" "32.7" "34.1" "34.6" "34.5" "34.5" "31.1" "27.5" "42.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4926655616225133563" "False" "High" "IsMasterProtein" "Q86TI0" "TBC1 domain family member 1 OS=Homo sapiens OX=9606 GN=TBC1D1 PE=1 SV=2" "0.010" "False" "2.117" "1" "1" "1" "1" "1168" "133.0" "6.96" "0.00" "1" "" "nucleus" "enzyme regulator activity" "Pf00566, Pf00640, Pf11830" "23216" "ENSG00000065882" "TBC1D1" "B7Z3D9; E9PGH8; hsa:23216; Q86TI0; Q96K82; Q9UPP4" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6076863243069163850" "False" "High" "IsMasterProtein" "Q8WX93" "Palladin OS=Homo sapiens OX=9606 GN=PALLD PE=1 SV=3" "0.010" "False" "2.116" "1" "1" "1" "1" "1383" "150.5" "7.09" "3.59" "1" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf07679" "23022" "ENSG00000129116" "PALLD" "B3KTG2; B5MD56; B7ZMM5; hsa:23022; Q7L3E0; Q7Z3W0; Q86WE8; Q8N1M2; Q8WX93; Q9UGA0; Q9UQF5; Q9Y2J6; Q9Y3E9" "" "" "0" "0" "1.086" "1.085" "1.033" "1.029" "1.082" "1.241" "0.720" "0.855" "2.393" "111.2" "120.7" "120.7" "114.9" "114.4" "120.3" "138.0" "80.0" "95.0" "266.0" "" "" "" "" "" "" "" "" "" "" "58.9" "66.9" "69.1" "52.9" "61.9" "66.9" "81.2" "43.7" "53.3" "266.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3534429540462627294" "False" "High" "IsMasterProtein" "P09525" "Annexin A4 OS=Homo sapiens OX=9606 GN=ANXA4 PE=1 SV=4" "0.010" "False" "2.114" "3" "1" "1" "1" "319" "35.9" "6.13" "2.02" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00191" "307" "ENSG00000196975" "ANXA4" "B4DDF9; hsa:307; P09525; Q6LES2; Q96F33; Q9BWK1" "Prostaglandin synthesis and regulation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5530400762788936201" "False" "High" "IsMasterProtein" "O43299" "AP-5 complex subunit zeta-1 OS=Homo sapiens OX=9606 GN=AP5Z1 PE=1 SV=2" "0.010" "False" "2.112" "1" "1" "1" "1" "807" "88.5" "7.01" "2.56" "1" "DNA metabolism;stress response;transport" "other membranes;nucleus;other cytoplasmic organelle;other cell component" "" "Pf14764" "9907" "ENSG00000242802" "AP5Z1" "hsa:9907; O43299; Q8N3X2; Q96H80" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7486166187731566186" "False" "High" "IsMasterProtein" "Q9BV57" "Acireductone dioxygenase OS=Homo sapiens OX=9606 GN=ADI1 PE=1 SV=1" "0.010" "False" "2.110" "9" "1" "1" "1" "179" "21.5" "5.68" "0.00" "1" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03079" "55256" "ENSG00000182551" "ADI1" "D6W4Y3; hsa:55256; Q53HW3; Q53QD3; Q57YV7; Q68CK2; Q6ZSF7; Q7Z512; Q96P85; Q9BV57; Q9NV57" "Methionine de novo and salvage pathway" "Methionine salvage pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9099415838211122916" "False" "Medium" "IsMasterProtein" "P33981" "Dual specificity protein kinase TTK OS=Homo sapiens OX=9606 GN=TTK PE=1 SV=2" "0.010" "False" "2.109" "1" "1" "1" "1" "857" "97.0" "8.16" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "7272" "ENSG00000112742" "TTK" "A8K8U5; B2RDW2; E1P543; hsa:7272; P33981; Q15272; Q5TCS0; Q9BW51; Q9NTM0" "Cell cycle; Retinoblastoma gene in cancer" "" "2" "0" "0.932" "0.875" "0.912" "0.890" "0.909" "0.958" "0.808" "0.866" "1.477" "126.4" "117.9" "110.6" "115.2" "112.5" "114.9" "121.1" "102.1" "109.4" "186.6" "" "" "" "" "" "" "" "" "" "" "66.9" "65.3" "63.3" "53.1" "60.9" "63.9" "71.3" "55.7" "61.4" "186.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7043432361938153889" "False" "Medium" "IsMasterProtein" "Q8NCP5" "Zinc finger and BTB domain-containing protein 44 OS=Homo sapiens OX=9606 GN=ZBTB44 PE=1 SV=1" "0.010" "False" "2.106" "2" "1" "1" "1" "570" "63.8" "6.61" "2.00" "1" "" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "29068" "ENSG00000196323" "ZBTB44" "hsa:29068; Q6IPT8; Q86VJ7; Q86XX5; Q8NCP5" "" "" "0" "0" "1.399" "1.327" "1.383" "1.312" "1.270" "1.352" "1.404" "1.382" "1.050" "32.9" "46.0" "43.7" "45.5" "43.1" "41.8" "44.5" "46.2" "45.5" "34.5" "" "" "" "" "" "" "" "" "" "" "17.4" "25.5" "25.0" "21.0" "23.3" "23.2" "26.2" "25.2" "25.5" "34.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2756715641617958921" "False" "Medium" "IsMasterProtein" "Q8N0T1" "Ribosomal biogenesis factor OS=Homo sapiens OX=9606 GN=RBIS PE=1 SV=4" "0.010" "False" "2.106" "9" "1" "1" "1" "100" "11.4" "10.46" "2.01" "1" "other biological processes" "cytosol;nucleus" "" "Pf15679" "401466" "ENSG00000176731" "RBIS" "B2RXE7; E5RFW5; hsa:401466; Q8N0T1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6765720071674471585" "False" "Medium" "IsMasterProtein" "Q15633" "RISC-loading complex subunit TARBP2 OS=Homo sapiens OX=9606 GN=TARBP2 PE=1 SV=3" "0.011" "False" "2.104" "2" "1" "1" "1" "366" "39.0" "6.54" "2.88" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035" "6895" "ENSG00000139546" "TARBP2" "hsa:6895; Q12878; Q15633; Q8WY32; Q8WY33; Q9BRY2" "Fragile X syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "MicroRNA (miRNA) biogenesis; PKR-mediated signaling; Small interfering RNA (siRNA) biogenesis" "6" "0" "1.151" "1.028" "1.172" "1.243" "1.030" "1.282" "1.340" "1.193" "1.576" "176.4" "203.1" "181.3" "206.8" "219.2" "181.6" "226.2" "236.3" "210.4" "278.0" "" "" "" "" "" "" "" "" "" "" "93.4" "112.6" "103.9" "95.2" "118.6" "101.0" "133.1" "129.0" "118.1" "278.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6764322891151840328" "False" "Medium" "IsMasterProtein" "P19484" "Transcription factor EB OS=Homo sapiens OX=9606 GN=TFEB PE=1 SV=3" "0.011" "False" "2.104" "2" "1" "1" "1" "476" "52.8" "6.29" "1.78" "1" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010, Pf11851, Pf15951" "7942" "ENSG00000112561" "TFEB" "hsa:7942; P19484; Q709B3; Q7Z6P9; Q9BRJ5; Q9UJD8" "PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Type 2 papillary renal cell carcinoma; Autophagy in pancreatic ductal adenocarcinoma" "" "3" "0" "1.436" "1.135" "0.718" "1.078" "1.115" "1.267" "0.748" "1.292" "2.975" "20.5" "29.4" "23.2" "14.7" "22.1" "22.8" "25.9" "15.3" "26.5" "60.9" "" "" "" "" "" "" "" "" "" "" "10.8" "16.3" "13.3" "6.8" "11.9" "12.7" "15.3" "8.4" "14.8" "60.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3948795116760064813" "False" "Medium" "IsMasterProtein" "Q7Z2Z2" "Elongation factor-like GTPase 1 OS=Homo sapiens OX=9606 GN=EFL1 PE=1 SV=2" "0.011" "False" "2.101" "1" "1" "2" "1" "1120" "125.4" "5.91" "4.95" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf14492" "79631" "ENSG00000140598" "EFL1" "A6NKY5; B7Z6I0; hsa:79631; Q7Z2Z2; Q9H8Z6" "Genetic causes of porto-sinusoidal vascular disease" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4924966722197614232" "False" "Medium" "IsMasterProtein" "Q8TB37" "Iron-sulfur cluster transfer protein NUBPL OS=Homo sapiens OX=9606 GN=NUBPL PE=1 SV=3" "0.011" "False" "2.101" "2" "1" "1" "1" "319" "34.1" "9.04" "2.67" "1" "cell organization and biogenesis" "plasma membrane;other membranes;mitochondrion" "other molecular function" "Pf10609" "80224" "ENSG00000151413" "NUBPL" "B4DHZ1; hsa:80224; Q86TZ4; Q8TB37; Q9H9M2" "Epithelial to mesenchymal transition in colorectal cancer" "Complex I biogenesis" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-123895126992999128" "False" "Medium" "IsMasterProtein" "Q96BR5" "Cytochrome c oxidase assembly factor 7 OS=Homo sapiens OX=9606 GN=COA7 PE=1 SV=2" "0.011" "False" "2.101" "3" "1" "1" "1" "231" "25.7" "6.02" "3.01" "1" "" "mitochondrion;nucleus" "" "Pf08238" "65260" "ENSG00000162377" "COA7" "hsa:65260; Q0P6I7; Q96BR5; Q9H9Z9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1020812304193846387" "False" "Medium" "IsMasterProtein" "Q96ED9" "Protein Hook homolog 2 OS=Homo sapiens OX=9606 GN=HOOK2 PE=1 SV=3" "0.011" "False" "2.097" "1" "1" "1" "1" "719" "83.2" "5.47" "2.41" "1" "cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf05622, Pf19047" "29911" "ENSG00000095066" "HOOK2" "hsa:29911; O60562; Q96ED9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6462604528965410945" "False" "Medium" "IsMasterProtein" "O15392" "Baculoviral IAP repeat-containing protein 5 OS=Homo sapiens OX=9606 GN=BIRC5 PE=1 SV=3" "0.011" "False" "2.091" "5" "1" "1" "1" "142" "16.4" "5.90" "2.55" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00653" "332" "ENSG00000089685" "BIRC5" "A2SUH6; B2R4R1; hsa:332; O15392; Q2I3N8; Q4VGX0; Q53F61; Q5MGC6; Q6FHL2; Q75SP2; Q9P2W8" "Apoptosis modulation and signaling; Interleukin-11 signaling pathway; Apoptosis; Apoptosis-related network due to altered Notch3 in ovarian cancer; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced HIF-1 survival signaling; Photodynamic therapy-induced NF-kB survival signaling; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling; IL-4 signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Extracellular vesicles in the crosstalk of cardiac cells; Gastrin signaling pathway; Hepatitis B infection; HDAC6 interactions in the central nervous system" "Separation of Sister Chromatids; Neddylation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; SUMOylation of DNA replication proteins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Interleukin-4 and Interleukin-13 signaling; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "25" "0" "0.917" "1.050" "0.944" "0.989" "1.095" "0.916" "1.079" "1.032" "0.480" "260.8" "239.1" "273.7" "246.1" "258.0" "285.5" "238.8" "281.5" "269.0" "125.1" "" "" "" "" "" "" "" "" "" "" "138.1" "132.6" "156.8" "113.3" "139.6" "158.8" "140.5" "153.6" "150.9" "125.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-383335111069342987" "False" "Medium" "IsMasterProtein" "Q6PD74" "Alpha- and gamma-adaptin-binding protein p34 OS=Homo sapiens OX=9606 GN=AAGAB PE=1 SV=1" "0.011" "False" "2.089" "3" "1" "1" "1" "315" "34.6" "4.64" "2.75" "1" "transport" "cytosol;nucleus;other cell component" "" "Pf10199" "79719" "ENSG00000103591" "AAGAB" "B4DG44; hsa:79719; Q6FI86; Q6PD74; Q7Z5X9; Q9H0P1; Q9HAK0" "" "" "0" "0" "1.091" "0.930" "0.880" "1.388" "0.982" "1.333" "1.244" "1.414" "1.403" "38.9" "42.5" "36.2" "34.3" "54.1" "38.2" "51.9" "48.4" "55.1" "54.6" "" "" "" "" "" "" "" "" "" "" "20.6" "23.6" "20.7" "15.8" "29.2" "21.3" "30.6" "26.4" "30.9" "54.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-32317680153119671" "False" "Medium" "IsMasterProtein" "O95620" "tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like OS=Homo sapiens OX=9606 GN=DUS4L PE=1 SV=2" "0.011" "False" "2.088" "3" "1" "1" "1" "317" "35.8" "7.33" "2.00" "1" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf01207" "11062" "ENSG00000105865; ENSG00000284103" "DUS4L" "B4DLX0; hsa:11062; O95620; Q2NKK1" "" "" "0" "0" "0.966" "1.120" "1.031" "1.221" "1.015" "0.989" "0.954" "0.867" "0.813" "180.6" "174.5" "202.3" "186.2" "220.6" "183.4" "178.5" "172.4" "156.6" "146.8" "" "" "" "" "" "" "" "" "" "" "95.6" "96.8" "115.8" "85.8" "119.3" "102.0" "105.1" "94.1" "87.9" "146.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9072204051848657082" "False" "Medium" "IsMasterProtein" "O75832" "26S proteasome non-ATPase regulatory subunit 10 OS=Homo sapiens OX=9606 GN=PSMD10 PE=1 SV=1" "0.011" "False" "2.083" "3" "1" "1" "1" "226" "24.4" "6.10" "3.11" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf12796" "5716" "ENSG00000101843" "PSMD10" "hsa:5716; O75832; Q5U0B2; Q8IZK9" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway" "Degradation of DVL; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "61" "0" "1.024" "1.047" "1.030" "0.884" "1.059" "1.019" "0.851" "1.123" "3.418" "253.7" "259.8" "265.5" "261.2" "224.2" "268.6" "258.4" "215.8" "284.8" "866.9" "" "" "" "" "" "" "" "" "" "" "134.3" "144.0" "152.1" "120.3" "121.3" "149.4" "152.1" "117.8" "159.8" "866.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5445595242509398747" "False" "Medium" "IsMasterProtein" "Q9UQL6" "Histone deacetylase 5 OS=Homo sapiens OX=9606 GN=HDAC5 PE=1 SV=2" "0.011" "False" "2.082" "1" "1" "1" "1" "1122" "121.9" "6.24" "1.65" "1" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00850, Pf12203" "10014" "ENSG00000108840" "HDAC5" "C9JFV9; hsa:10014; O60340; O60528; Q96DY4; Q9UQL6" "MicroRNAs in cardiomyocyte hypertrophy; Cell differentiation - expanded index; Cell differentiation - index; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; Rett syndrome" "Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of PTEN gene transcription" "14" "0" "0.871" "1.143" "1.154" "1.294" "1.204" "1.352" "0.969" "0.914" "2.021" "41.5" "36.2" "47.5" "47.9" "53.8" "50.0" "56.2" "40.2" "38.0" "84.0" "" "" "" "" "" "" "" "" "" "" "22.0" "20.1" "27.2" "22.1" "29.1" "27.8" "33.1" "22.0" "21.3" "84.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6807654734568347252" "False" "Medium" "IsMasterProtein" "Q9H972" "Uncharacterized protein C14orf93 OS=Homo sapiens OX=9606 GN=C14orf93 PE=1 SV=1" "0.011" "False" "2.081" "2" "1" "1" "1" "538" "58.7" "5.99" "0.00" "1" "other biological processes" "non-structural extracellular" "" "Pf15394" "60686" "ENSG00000100802" "C14orf93" "B7WP03; D3DS38; D3DS39; hsa:60686; Q86SE6; Q96CF7; Q9H972; Q9HA68" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6229866583710047273" "False" "Medium" "IsMasterProtein" "Q96C23" "Galactose mutarotase OS=Homo sapiens OX=9606 GN=GALM PE=1 SV=1" "0.012" "False" "2.075" "3" "1" "1" "1" "342" "37.7" "6.65" "2.37" "1" "other metabolic processes" "other cell component" "other molecular function" "Pf01263" "130589" "ENSG00000143891" "GALM" "hsa:130589; Q53RY1; Q8NIA2; Q96C23; V9HWA8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4972524321603701932" "False" "Medium" "IsMasterProtein" "Q8IW35" "Centrosomal protein of 97 kDa OS=Homo sapiens OX=9606 GN=CEP97 PE=1 SV=1" "0.012" "False" "2.074" "1" "1" "2" "1" "865" "96.9" "5.02" "4.68" "1" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf14580" "79598" "ENSG00000182504" "CEP97" "B5MDY8; hsa:79598; Q8IW35; Q8NA71; Q9H5T9" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Joubert syndrome" "Anchoring of the basal body to the plasma membrane; RHOV GTPase cycle" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5271819707192533656" "False" "Medium" "IsMasterProtein" "Q9H7E9" "UPF0488 protein C8orf33 OS=Homo sapiens OX=9606 GN=C8orf33 PE=1 SV=1" "0.013" "False" "2.066" "3" "1" "1" "1" "229" "25.0" "9.95" "2.39" "1" "" "" "" "Pf15393" "65265" "ENSG00000182307; ENSG00000291362" "C8orf33" "A6NGC0; hsa:65265; Q96BT8; Q9H7E9" "" "" "0" "0" "1.014" "0.919" "1.018" "0.940" "0.942" "0.946" "0.844" "0.956" "1.313" "88.7" "90.0" "81.5" "90.3" "83.4" "83.6" "83.9" "74.9" "84.8" "116.4" "" "" "" "" "" "" "" "" "" "" "47.0" "49.9" "46.7" "41.6" "45.1" "46.5" "49.4" "40.9" "47.6" "116.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5434950316255047491" "False" "Medium" "IsMasterProtein" "P42224" "Signal transducer and activator of transcription 1-alpha/beta OS=Homo sapiens OX=9606 GN=STAT1 PE=1 SV=2" "0.013" "False" "2.060" "1" "1" "1" "1" "750" "87.3" "6.05" "2.88" "1" "cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf12162, Pf21354" "6772" "ENSG00000115415" "STAT1" "A8K989; B2RCA0; D2KFR8; D3DPI7; hsa:6772; P42224; Q53S88; Q53XW4; Q68D00; Q9UDL5" "IL-5 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Type III interferon signaling; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Allograft rejection; Interleukin-11 signaling pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Endoderm differentiation; Kit receptor signaling pathway; IL6 signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; p38 MAPK signaling pathway; Immune response to tuberculosis; Ebola virus infection in host; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; IL-10 anti-inflammatory signaling pathway ; Overview of interferons-mediated signaling pathway; Measles virus infection; Tryptophan metabolism; Hepatitis B infection; Endochondral ossification; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Endochondral ossification with skeletal dysplasias; TGF-beta receptor signaling in skeletal dysplasias; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; IL-2 signaling pathway; SARS coronavirus and innate immunity; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; CCL18 signaling pathway; Th17 cell differentiation pathway; Inflammatory bowel disease signaling; 2q13 copy number variation syndrome; TROP2 regulatory signaling; IL-26 signaling pathways; JAK-STAT signaling in the regulation of beta cells; IL-19 signaling pathway; TGF-beta receptor signaling; EPO receptor signaling; Interferon type I signaling pathways; Type II interferon signaling; Toll-like receptor signaling pathway" "Growth hormone receptor signaling; PKR-mediated signaling; Interleukin-4 and Interleukin-13 signaling; Signaling by CSF1 (M-CSF) in myeloid cells; Regulation of RUNX2 expression and activity; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signaling by ALK fusions and activated point mutants; Signaling by SCF-KIT; Downstream signal transduction; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; Interleukin-6 signaling; Interferon alpha/beta signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Signaling by cytosolic FGFR1 fusion mutants; NOTCH3 Intracellular Domain Regulates Transcription; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-27 signaling; Interleukin-9 signaling; Interleukin-21 signaling" "83" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7765133988428364561" "False" "Medium" "IsMasterProtein" "Q58WW2" "DDB1- and CUL4-associated factor 6 OS=Homo sapiens OX=9606 GN=DCAF6 PE=1 SV=1" "0.013" "False" "2.053" "1" "1" "1" "1" "860" "96.2" "5.27" "2.98" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "55827" "ENSG00000143164" "DCAF6" "A2A295; B4DNB8; hsa:55827; Q58WW2; Q7L8I0; Q8IXH3; Q8TB19" "" "Neddylation" "1" "0" "1.156" "0.988" "1.361" "1.153" "1.070" "1.210" "1.240" "1.073" "0.804" "169.6" "196.1" "167.5" "230.7" "195.4" "181.4" "205.2" "210.2" "182.0" "136.4" "" "" "" "" "" "" "" "" "" "" "89.8" "108.7" "95.9" "106.3" "105.7" "100.9" "120.8" "114.7" "102.1" "136.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4009101809611603487" "False" "Medium" "IsMasterProtein" "Q9NUW8" "Tyrosyl-DNA phosphodiesterase 1 OS=Homo sapiens OX=9606 GN=TDP1 PE=1 SV=2" "0.013" "False" "2.051" "1" "1" "1" "1" "608" "68.4" "7.65" "2.56" "1" "DNA metabolism;other metabolic processes;stress response" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06087" "55775" "ENSG00000042088" "TDP1" "hsa:55775; Q2HXX4; Q86TV8; Q96BK7; Q9NUW8; Q9NZM7; Q9NZM8" "" "Nonhomologous End-Joining (NHEJ)" "1" "0" "0.946" "0.806" "1.118" "1.260" "0.917" "2.076" "1.641" "1.926" "2.541" "47.7" "45.1" "38.5" "53.3" "60.1" "43.7" "99.0" "78.3" "91.9" "121.2" "" "" "" "" "" "" "" "" "" "" "25.3" "25.0" "22.0" "24.6" "32.5" "24.3" "58.3" "42.7" "51.5" "121.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5233770781209120367" "False" "Medium" "IsMasterProtein" "Q9H5J0" "Zinc finger and BTB domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZBTB3 PE=1 SV=1" "0.013" "False" "2.050" "1" "1" "1" "1" "574" "61.8" "5.62" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "" "ENSG00000185670" "ZBTB3" "Q9H5J0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7752338987200815694" "False" "Medium" "IsMasterProtein" "Q9NQT4" "Exosome complex component RRP46 OS=Homo sapiens OX=9606 GN=EXOSC5 PE=1 SV=1" "0.013" "False" "2.050" "4" "1" "1" "1" "235" "25.2" "7.59" "2.15" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "56915" "ENSG00000077348" "EXOSC5" "hsa:56915; Q32Q81; Q8NG16; Q96I89; Q9NQT4" "" "ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Major pathway of rRNA processing in the nucleolus and cytosol; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3934264021141742446" "False" "Medium" "IsMasterProtein" "Q9UI12" "V-type proton ATPase subunit H OS=Homo sapiens OX=9606 GN=ATP6V1H PE=1 SV=1" "0.013" "False" "2.043" "2" "1" "1" "1" "483" "55.8" "6.48" "0.00" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "transporter activity;enzyme regulator activity" "Pf03224, Pf11698" "51606" "ENSG00000047249" "ATP6V1H" "B3KMR0; hsa:51606; Q6PK44; Q9H3E3; Q9UI12; Q9Y300" "Proximal tubule transport" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport; Nef Mediated CD4 Down-regulation; Nef Mediated CD8 Down-regulation; Blockage of phagosome acidification" "9" "0" "1.131" "1.034" "1.272" "1.150" "1.094" "1.209" "1.173" "1.220" "0.865" "101.7" "115.1" "105.2" "129.4" "117.0" "111.3" "123.0" "119.4" "124.1" "88.0" "" "" "" "" "" "" "" "" "" "" "53.9" "63.8" "60.2" "59.6" "63.3" "61.9" "72.4" "65.2" "69.6" "88.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8721939623497573862" "False" "Medium" "IsMasterProtein" "Q86YV5" "Inactive tyrosine-protein kinase PRAG1 OS=Homo sapiens OX=9606 GN=PRAG1 PE=1 SV=4" "0.013" "False" "2.042" "1" "1" "1" "1" "1406" "149.5" "7.20" "1.78" "1" "other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf07714" "157285" "ENSG00000275342" "PRAG1" "Q86YV5; Q8N3N5" "" "RND2 GTPase cycle" "1" "0" "0.844" "1.051" "0.939" "1.066" "0.888" "1.126" "1.440" "1.195" "1.031" "21.7" "18.3" "22.8" "20.4" "23.1" "19.3" "24.4" "31.2" "25.9" "22.3" "" "" "" "" "" "" "" "" "" "" "11.5" "10.1" "13.0" "9.4" "12.5" "10.7" "14.4" "17.0" "14.5" "22.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5823057819559300912" "False" "Medium" "IsMasterProtein" "O15230" "Laminin subunit alpha-5 OS=Homo sapiens OX=9606 GN=LAMA5 PE=1 SV=8" "0.013" "False" "2.042" "0" "1" "1" "1" "3695" "399.5" "7.02" "2.70" "1" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;other cell component" "signal transduction activity or receptor binding" "Pf00052, Pf00053, Pf00054, Pf00055, Pf02210, Pf06008, Pf06009" "3911" "ENSG00000130702" "LAMA5" "hsa:3911; O15230; Q5U4N9; Q8TDF8; Q8WZA7; Q9H1P1" "Alpha 6 beta 4 signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Complement system; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Inflammatory response pathway; Small cell lung cancer; Pleural mesothelioma" "Degradation of the extracellular matrix; ECM proteoglycans; Non-integrin membrane-ECM interactions; Interleukin-4 and Interleukin-13 signaling; Laminin interactions; MET activates PTK2 signaling" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "121458031031999340" "False" "Medium" "IsMasterProtein" "P35232" "Prohibitin 1 OS=Homo sapiens OX=9606 GN=PHB1 PE=1 SV=1" "0.013" "False" "2.039" "4" "1" "1" "1" "272" "29.8" "5.76" "2.37" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01145" "5245" "ENSG00000167085" "PHB1" "B4DY47; hsa:5245; P35232; Q4VBQ0" "" "RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Processing of SMDT1" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4879216047058048587" "False" "Medium" "IsMasterProtein" "P81605" "Dermcidin OS=Homo sapiens OX=9606 GN=DCD PE=1 SV=2" "0.013" "False" "2.037" "6" "1" "1" "1" "110" "11.3" "6.54" "2.48" "1" "protein metabolism;stress response;transport" "non-structural extracellular;other membranes" "transporter activity;other molecular function" "Pf15291" "117159" "ENSG00000161634" "DCD" "A5JHP2; A5JHP3; hsa:117159; P58461; P81605; Q53YJ2" "" "Antimicrobial peptides" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5403362594162546688" "False" "Medium" "IsMasterProtein" "Q15007" "Pre-mRNA-splicing regulator WTAP OS=Homo sapiens OX=9606 GN=WTAP PE=1 SV=2" "0.013" "False" "2.035" "2" "1" "1" "1" "396" "44.2" "5.19" "0.00" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf17098" "9589" "ENSG00000146457" "WTAP" "hsa:9589; Q15007; Q5TCL8; Q5TCL9; Q96T28; Q9BYJ7; Q9H4E2" "" "Processing of Capped Intron-Containing Pre-mRNA" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2541081725476023529" "False" "Medium" "IsMasterProtein" "Q8NBJ7" "Inactive C-alpha-formylglycine-generating enzyme 2 OS=Homo sapiens OX=9606 GN=SUMF2 PE=1 SV=2" "0.013" "False" "2.032" "3" "1" "1" "1" "301" "33.8" "8.00" "2.91" "1" "" "ER/Golgi" "other molecular function" "Pf03781" "25870" "ENSG00000129103" "SUMF2" "B4DU41; B4DWQ0; hsa:25870; Q14DW5; Q53ZE3; Q8NBJ7; Q96BH2; Q9BRN3; Q9BWI1; Q9Y405" "" "Glycosphingolipid catabolism; The activation of arylsulfatases" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "876115928982754265" "False" "Medium" "IsMasterProtein" "P00519" "Tyrosine-protein kinase ABL1 OS=Homo sapiens OX=9606 GN=ABL1 PE=1 SV=4" "0.013" "False" "2.030" "1" "1" "1" "1" "1130" "122.8" "8.66" "1.67" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714, Pf08919" "25" "ENSG00000097007" "ABL1" "A3KFJ3; hsa:25; P00519; Q13869; Q13870; Q16133; Q17R61; Q45F09" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; TP53 network; Cell cycle; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; Retinoblastoma gene in cancer; ATM signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Imatinib and chronic myeloid leukemia; VEGFA-VEGFR2 signaling; Ras signaling; Acute viral myocarditis; EGF/EGFR signaling pathway; Macrophage-stimulating protein (MSP) signaling network map; 5q35 copy number variation; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RHO GTPases Activate WASPs and WAVEs; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Myogenesis; Cyclin D associated events in G1; Factors involved in megakaryocyte development and platelet production; RUNX2 regulates osteoblast differentiation; HDR through Single Strand Annealing (SSA); Role of ABL in ROBO-SLIT signaling" "30" "0" "1.060" "1.057" "1.131" "1.220" "1.190" "1.419" "1.437" "1.378" "1.607" "45.8" "48.5" "48.3" "51.8" "55.8" "54.4" "64.9" "65.7" "63.1" "73.5" "" "" "" "" "" "" "" "" "" "" "24.2" "26.9" "27.7" "23.8" "30.2" "30.3" "38.2" "35.9" "35.4" "73.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7437759637941576864" "False" "Medium" "IsMasterProtein" "Q92597" "Protein NDRG1 OS=Homo sapiens OX=9606 GN=NDRG1 PE=1 SV=1" "0.013" "False" "2.030" "4" "1" "1" "1" "394" "42.8" "5.82" "0.00" "1" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf03096" "10397" "ENSG00000104419" "NDRG1" "B3KR80; B7Z446; hsa:10397; O15207; Q6IBG2; Q92597; Q9NYR6; Q9UK29" "Androgen receptor network in prostate cancer; VEGFA-VEGFR2 signaling; Hippo-YAP signaling; Leukocyte-intrinsic Hippo pathway functions; Intracellular trafficking proteins involved in CMT neuropathy; Pleural mesothelioma; Macrophage-stimulating protein (MSP) signaling network map" "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5905878438801314627" "False" "Medium" "IsMasterProtein" "P50151" "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 OS=Homo sapiens OX=9606 GN=GNG10 PE=1 SV=1" "0.013" "False" "2.027" "10" "1" "1" "1" "68" "7.2" "7.85" "2.30" "1" "signal transduction" "plasma membrane;other membranes" "other molecular function" "Pf00631" "2790" "ENSG00000242616" "GNG10" "hsa:2790; P50151; Q3B7K2; Q4VC27" "G protein signaling pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling" "GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation" "33" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3091495107374211726" "False" "Medium" "IsMasterProtein" "Q9H501" "ESF1 homolog OS=Homo sapiens OX=9606 GN=ESF1 PE=1 SV=1" "0.013" "False" "2.023" "1" "1" "1" "1" "851" "98.7" "5.11" "2.14" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf08159" "51575" "ENSG00000089048" "ESF1" "hsa:51575; Q86X92; Q9H501; Q9H9Q5; Q9HA35; Q9NX93; Q9P1S6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8587567595163417034" "False" "Medium" "IsMasterProtein" "Q9UIQ6" "Leucyl-cystinyl aminopeptidase OS=Homo sapiens OX=9606 GN=LNPEP PE=1 SV=3" "0.013" "False" "2.014" "1" "1" "1" "1" "1025" "117.3" "5.73" "2.95" "1" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01433, Pf11838, Pf17900" "4012" "ENSG00000113441" "LNPEP" "hsa:4012; O00769; Q15145; Q59H76; Q9TNQ2; Q9TNQ3; Q9UIQ6; Q9UIQ7" "" "Antigen processing: Ubiquitination & Proteasome degradation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Endosomal/Vacuolar pathway" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7234885358333908901" "False" "Medium" "IsMasterProtein" "O75915" "PRA1 family protein 3 OS=Homo sapiens OX=9606 GN=ARL6IP5 PE=1 SV=1" "0.013" "False" "2.012" "4" "1" "1" "1" "188" "21.6" "9.77" "2.65" "1" "other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi" "" "Pf03208" "10550" "ENSG00000144746" "ARL6IP5" "B2R6V5; hsa:10550; O75915; Q53ES3; Q5KU08" "" "Glutamate Neurotransmitter Release Cycle" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "864324901755663317" "False" "Medium" "IsMasterProtein" "Q8TAP9" "M-phase-specific PLK1-interacting protein OS=Homo sapiens OX=9606 GN=MPLKIP PE=1 SV=1" "0.013" "False" "2.010" "5" "1" "1" "1" "179" "19.1" "10.23" "3.01" "1" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;ER/Golgi;nucleus;other cell component" "" "Pf15502" "136647" "ENSG00000168303" "MPLKIP" "hsa:136647; Q8TAP9" "" "" "0" "0" "1.081" "1.063" "0.955" "0.979" "0.964" "0.929" "0.908" "0.889" "0.639" "152.5" "164.9" "162.1" "145.6" "149.4" "147.0" "141.8" "138.4" "135.5" "97.5" "" "" "" "" "" "" "" "" "" "" "80.8" "91.4" "92.8" "67.1" "80.8" "81.8" "83.4" "75.6" "76.0" "97.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3311926917854502333" "False" "Medium" "IsMasterProtein" "O43414" "ERI1 exoribonuclease 3 OS=Homo sapiens OX=9606 GN=ERI3 PE=1 SV=2" "0.013" "False" "2.007" "3" "1" "1" "1" "337" "37.2" "8.07" "2.35" "1" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf00929" "79033" "ENSG00000117419" "ERI3" "B1AK98; hsa:79033; O43414; Q5T2T7; Q5T2T9; Q5TG35; Q9BQA0; Q9UEB4" "" "" "0" "0" "0.920" "0.971" "1.073" "1.121" "1.119" "0.892" "0.926" "1.049" "0.454" "346.2" "318.3" "336.0" "371.3" "388.0" "387.5" "308.6" "320.6" "363.2" "157.2" "" "" "" "" "" "" "" "" "" "" "183.3" "176.5" "192.4" "171.0" "209.9" "215.5" "181.6" "175.0" "203.8" "157.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7666744292030772641" "False" "Medium" "IsMasterProtein" "Q9BRK5" "45 kDa calcium-binding protein OS=Homo sapiens OX=9606 GN=SDF4 PE=1 SV=1" "0.013" "False" "2.006" "2" "1" "1" "1" "362" "41.8" "4.86" "0.00" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13202, Pf13499" "51150" "" "SDF4" "B1AME5; B1AME6; B2RDF1; B4DSM1; hsa:51150; Q53G52; Q53HQ9; Q8NBQ3; Q96AA1; Q9BRK5; Q9NZP7; Q9UN53" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7069334460136082352" "False" "Medium" "IsMasterProtein" "Q9Y4P8" "WD repeat domain phosphoinositide-interacting protein 2 OS=Homo sapiens OX=9606 GN=WIPI2 PE=1 SV=1" "0.013" "False" "2.004" "2" "1" "1" "1" "454" "49.4" "6.46" "2.39" "1" "cell organization and biogenesis;other metabolic processes;stress response" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf21032" "26100" "ENSG00000157954" "WIPI2" "B3KNC2; hsa:26100; Q5MNZ8; Q6FI96; Q75L50; Q96IE4; Q9Y364; Q9Y4P8" "Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease; ADHD and autism (ASD) linked metabolic pathways and SNP" "Macroautophagy" "6" "0" "0.910" "0.964" "1.246" "1.347" "1.171" "2.213" "2.042" "2.074" "2.307" "204.3" "185.9" "197.0" "254.6" "275.2" "239.2" "452.1" "417.3" "423.8" "471.4" "" "" "" "" "" "" "" "" "" "" "108.2" "103.1" "112.8" "117.2" "148.9" "133.1" "266.1" "227.8" "237.7" "471.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2076182377996629975" "False" "Medium" "IsMasterProtein" "Q9H8U3" "AN1-type zinc finger protein 3 OS=Homo sapiens OX=9606 GN=ZFAND3 PE=1 SV=1" "0.013" "False" "2.004" "3" "1" "1" "1" "227" "25.2" "7.43" "2.55" "1" "" "" "nucleic acid binding activity;other molecular function" "Pf01428, Pf01754" "60685" "ENSG00000156639" "ZFAND3" "hsa:60685; Q5SZZ0; Q5SZZ1; Q9H8U3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6825792350743248999" "False" "Medium" "IsMasterProtein" "P07738" "Bisphosphoglycerate mutase OS=Homo sapiens OX=9606 GN=BPGM PE=1 SV=2" "0.013" "False" "2.004" "3" "1" "1" "1" "259" "30.0" "6.54" "2.76" "1" "other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf00300" "669" "ENSG00000172331" "BPGM" "A4D1N9; hsa:669; P07738" "IL-18 signaling pathway" "Glycolysis" "2" "0" "0.937" "0.897" "0.993" "0.959" "0.900" "0.847" "0.914" "0.845" "0.547" "189.6" "177.6" "170.1" "188.3" "181.9" "170.7" "160.6" "173.3" "160.2" "103.8" "" "" "" "" "" "" "" "" "" "" "100.4" "98.5" "97.4" "86.7" "98.4" "94.9" "94.5" "94.6" "89.8" "103.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4149430532130191750" "False" "Medium" "IsMasterProtein" "Q13057" "Bifunctional coenzyme A synthase OS=Homo sapiens OX=9606 GN=COASY PE=1 SV=4" "0.013" "False" "2.004" "1" "1" "1" "1" "564" "62.3" "6.99" "2.84" "1" "other metabolic processes" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf01121, Pf01467" "80347" "ENSG00000068120" "COASY" "B2RA78; B4DLU0; hsa:80347; Q13057; Q6GS23; Q8NBM7; Q8NEW1; Q8WXD4; Q9NRM3" "Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway" "Coenzyme A biosynthesis" "2" "0" "0.959" "0.971" "0.896" "0.943" "1.042" "0.924" "0.646" "0.870" "4.575" "117.2" "112.3" "113.7" "105.0" "110.5" "122.1" "108.3" "75.7" "101.9" "536.2" "" "" "" "" "" "" "" "" "" "" "62.1" "62.3" "65.1" "48.4" "59.8" "67.9" "63.8" "41.3" "57.2" "536.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9088626010110122517" "False" "Medium" "IsMasterProtein" "Q9UJX6" "Anaphase-promoting complex subunit 2 OS=Homo sapiens OX=9606 GN=ANAPC2 PE=1 SV=1" "0.013" "False" "2.000" "1" "1" "1" "1" "822" "93.8" "5.22" "2.42" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00888, Pf08672" "29882" "ENSG00000176248" "ANAPC2" "hsa:29882; Q5VSG1; Q96DG5; Q96GG4; Q9P2E1; Q9UJX6" "Cell cycle" "Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Senescence-Associated Secretory Phenotype (SASP); Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6810289511595074622" "False" "Medium" "IsMasterProtein" "Q15758" "Neutral amino acid transporter B(0) OS=Homo sapiens OX=9606 GN=SLC1A5 PE=1 SV=2" "0.013" "False" "2.000" "2" "1" "1" "1" "541" "56.6" "5.48" "2.53" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity;other molecular function" "Pf00375" "6510" "ENSG00000105281" "SLC1A5" "A8K9H5; B4DR77; B4DWS4; B7ZB81; D0EYG6; E9PC01; hsa:6510; O95720; Q15758; Q96RL9; Q9BWQ3; Q9UNP2" "TYROBP causal network in microglia; mRNA, protein, and metabolite inducation pathway by cyclosporin A; Metabolic reprogramming in colon cancer; Ferroptosis; Amino acid metabolism in triple-negative breast cancer cells" "RHOQ GTPase cycle; RAC1 GTPase cycle; RHOH GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; Amino acid transport across the plasma membrane" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7097092162087690863" "False" "Medium" "IsMasterProtein" "O43683" "Mitotic checkpoint serine/threonine-protein kinase BUB1 OS=Homo sapiens OX=9606 GN=BUB1 PE=1 SV=1" "0.013" "False" "1.997" "1" "1" "1" "1" "1085" "122.3" "6.47" "1.85" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf08311" "699" "ENSG00000169679" "BUB1" "E9PC26; F5GXI5; hsa:699; O43430; O43643; O43683; O60626; Q53QE4" "Cell cycle; ATM signaling in development and disease ; Regulation of sister chromatid separation at the metaphase-anaphase transition" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "9" "0" "1.262" "1.183" "1.150" "1.070" "1.310" "1.271" "0.767" "1.161" "5.061" "31.3" "39.5" "37.0" "36.0" "33.5" "41.0" "39.8" "24.0" "36.4" "158.4" "" "" "" "" "" "" "" "" "" "" "16.6" "21.9" "21.2" "16.6" "18.1" "22.8" "23.4" "13.1" "20.4" "158.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4123477520333659496" "False" "Medium" "IsMasterProtein" "Q7Z4G4" "tRNA (guanine(10)-N2)-methyltransferase homolog OS=Homo sapiens OX=9606 GN=TRMT11 PE=1 SV=1" "0.013" "False" "1.992" "2" "1" "1" "1" "463" "53.4" "7.78" "3.38" "1" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "nucleic acid binding activity" "Pf01170" "60487" "ENSG00000066651" "TRMT11" "E1P570; hsa:60487; Q5JY11; Q6PGQ5; Q7Z4G4; Q9HC13" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.896" "0.885" "0.886" "0.916" "0.923" "0.920" "0.873" "0.883" "0.489" "549.6" "492.4" "486.2" "486.9" "503.5" "507.3" "505.4" "479.9" "485.4" "268.6" "" "" "" "" "" "" "" "" "" "" "291.0" "273.0" "278.5" "224.2" "272.4" "282.2" "297.5" "261.9" "272.3" "268.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2202444694088095968" "False" "Medium" "IsMasterProtein" "Q5VXM1" "CUB domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CDCP2 PE=2 SV=2" "0.013" "False" "1.991" "2" "1" "1" "1" "540" "59.0" "5.94" "0.00" "1" "" "other membranes" "" "Pf00100, Pf00431" "" "ENSG00000157211" "CDCP2" "A0A1B0GU47" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8611257715597886633" "False" "Medium" "IsMasterProtein" "Q15555" "Microtubule-associated protein RP/EB family member 2 OS=Homo sapiens OX=9606 GN=MAPRE2 PE=1 SV=1" "0.013" "False" "1.991" "3" "1" "1" "1" "327" "37.0" "5.57" "1.86" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf03271" "10982" "ENSG00000166974" "MAPRE2" "B2RE21; B3KR39; B4DJV4; B7Z2L3; E9PHR3; F5H1V8; G5E9I6; hsa:10982; Q15555; Q9UQ33" "Ciliary landscape" "" "1" "0" "1.015" "0.913" "1.056" "1.170" "1.249" "0.988" "0.409" "0.927" "6.599" "63.4" "64.4" "57.9" "67.0" "74.2" "79.2" "62.7" "25.9" "58.8" "418.6" "" "" "" "" "" "" "" "" "" "" "33.6" "35.7" "33.2" "30.9" "40.2" "44.1" "36.9" "14.2" "33.0" "418.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3917086936507081280" "False" "Medium" "IsMasterProtein" "Q56P03" "E2F-associated phosphoprotein OS=Homo sapiens OX=9606 GN=EAPP PE=1 SV=4" "0.013" "False" "1.989" "5" "1" "1" "1" "285" "32.7" "5.12" "0.00" "1" "other biological processes" "nucleus;other cell component" "" "Pf10238" "55837" "ENSG00000129518" "EAPP" "hsa:55837; Q56P03; Q9BVF4; Q9NWV5; Q9NZ86" "" "" "0" "0" "1.114" "1.206" "1.275" "1.037" "1.227" "0.899" "1.004" "1.000" "1.153" "30.1" "33.5" "36.3" "38.4" "31.2" "36.9" "27.1" "30.2" "30.1" "34.7" "" "" "" "" "" "" "" "" "" "" "15.9" "18.6" "20.8" "17.7" "16.9" "20.6" "15.9" "16.5" "16.9" "34.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7444936349459715889" "False" "Medium" "IsMasterProtein" "Q32P28" "Prolyl 3-hydroxylase 1 OS=Homo sapiens OX=9606 GN=P3H1 PE=1 SV=2" "0.014" "False" "1.986" "2" "1" "1" "1" "736" "83.3" "5.14" "0.00" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf13640" "64175" "ENSG00000117385" "P3H1" "hsa:64175; Q32P28; Q7KZR4; Q96BR8; Q96SK8; Q96SL5; Q96SN3; Q9H6K3; Q9HC86; Q9HC87" "Type I collagen synthesis in the context of osteogenesis imperfecta" "Collagen biosynthesis and modifying enzymes" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-986396495116814729" "False" "Medium" "IsMasterProtein" "Q8IZ69" "tRNA (uracil-5-)-methyltransferase homolog A OS=Homo sapiens OX=9606 GN=TRMT2A PE=1 SV=2" "0.014" "False" "1.985" "2" "1" "1" "1" "625" "68.7" "7.94" "1.77" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol" "other molecular function" "Pf05958" "27037" "ENSG00000099899" "TRMT2A" "D3DX25; hsa:27037; Q32P57; Q8IZ69; Q96ME6; Q9H732" "22q11.2 copy number variation syndrome" "" "1" "0" "1.053" "1.039" "1.521" "1.093" "1.100" "1.061" "0.949" "0.821" "1.982" "46.0" "48.4" "47.8" "69.9" "50.2" "50.5" "48.7" "43.6" "37.7" "91.1" "" "" "" "" "" "" "" "" "" "" "24.3" "26.8" "27.4" "32.2" "27.2" "28.1" "28.7" "23.8" "21.2" "91.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5837225809424381126" "False" "Medium" "IsMasterProtein" "P51826" "AF4/FMR2 family member 3 OS=Homo sapiens OX=9606 GN=AFF3 PE=1 SV=3" "0.014" "False" "1.982" "1" "1" "1" "1" "1226" "133.4" "8.10" "2.77" "1" "developmental processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05110, Pf18875, Pf18876" "3899" "ENSG00000144218" "AFF3" "B7ZM46; B9EGL9; D3DVI6; P51826; Q53RD6; Q53S47; Q53SI6; Q53TB9; Q59F27; Q8IWJ5" "" "" "0" "0" "0.763" "0.790" "0.941" "0.933" "0.890" "1.081" "1.236" "1.337" "0.960" "59.9" "45.7" "47.4" "56.4" "56.0" "53.4" "64.8" "74.1" "80.2" "57.5" "" "" "" "" "" "" "" "" "" "" "31.7" "25.3" "27.1" "26.0" "30.3" "29.7" "38.1" "40.5" "45.0" "57.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7992266646399474025" "False" "Medium" "IsMasterProtein" "Q9Y605" "MORF4 family-associated protein 1 OS=Homo sapiens OX=9606 GN=MRFAP1 PE=1 SV=1" "0.014" "False" "1.977" "6" "1" "1" "1" "127" "14.6" "4.70" "2.70" "1" "" "nucleus;other cell component" "" "Pf15155" "93621" "ENSG00000179010" "MRFAP1" "B3KVT2; D3DVT3; hsa:93621; Q9Y605" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7824590419555307181" "False" "Medium" "IsMasterProtein" "P63165" "Small ubiquitin-related modifier 1 OS=Homo sapiens OX=9606 GN=SUMO1 PE=1 SV=1" "0.014" "False" "1.975" "7" "1" "2" "1" "101" "11.6" "5.52" "5.61" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf11976" "7341" "ENSG00000116030" "SUMO1" "A8MUS8; B2R4I5; hsa:7341; P55856; P63165; Q6FGG0; Q6NZ62; Q93068" "Androgen receptor signaling pathway; TP53 network; TGF-beta signaling pathway; Exercise-induced circadian regulation" "PKR-mediated signaling; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of DNA damage response and repair proteins; Formation of Incision Complex in GG-NER; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; Regulation of IFNG signaling; SUMOylation of transcription factors; Postmitotic nuclear pore complex (NPC) reformation; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; SUMOylation of nuclear envelope proteins; Maturation of nucleoprotein; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed" "27" "0" "1.030" "0.936" "1.135" "1.041" "0.875" "1.318" "1.233" "1.145" "1.527" "225.2" "231.9" "210.8" "255.7" "234.4" "197.1" "296.9" "277.7" "257.8" "343.8" "" "" "" "" "" "" "" "" "" "" "119.2" "128.6" "120.7" "117.7" "126.8" "109.6" "174.7" "151.6" "144.6" "343.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7829088903597684997" "False" "Medium" "IsMasterProtein" "O75976" "Carboxypeptidase D OS=Homo sapiens OX=9606 GN=CPD PE=1 SV=2" "0.014" "False" "1.973" "1" "1" "1" "1" "1380" "152.8" "6.05" "2.10" "1" "protein metabolism;other metabolic processes" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "Pf00246, Pf13620" "1362" "ENSG00000108582" "CPD" "B7Z7T9; B7ZAU4; F5GZH6; hsa:1362; O15377; O75976; Q86SH9; Q86XE6" "" "Golgi Associated Vesicle Biogenesis; RND3 GTPase cycle; RND1 GTPase cycle" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5441876211868438473" "False" "Medium" "IsMasterProtein" "Q92585" "Mastermind-like protein 1 OS=Homo sapiens OX=9606 GN=MAML1 PE=1 SV=3" "0.014" "False" "1.972" "1" "1" "1" "1" "1016" "108.0" "8.28" "2.48" "1" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09596, Pf20801, Pf20802" "9794" "ENSG00000161021; ENSG00000283780" "MAML1" "hsa:9794; Q92585; Q9NZ12" "Notch signaling; Canonical and non-canonical Notch signaling; Head and neck squamous cell carcinoma; Notch signaling pathway" "NOTCH3 Intracellular Domain Regulates Transcription; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH2 intracellular domain regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8565814559741767915" "False" "Medium" "IsMasterProtein" "Q16566" "Calcium/calmodulin-dependent protein kinase type IV OS=Homo sapiens OX=9606 GN=CAMK4 PE=1 SV=1" "0.014" "False" "1.972" "1" "1" "1" "1" "473" "51.9" "5.82" "2.75" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "814" "ENSG00000152495" "CAMK4" "D3DSZ7; hsa:814; Q16566" "Energy metabolism; Microtubule cytoskeleton regulation; Brain-derived neurotrophic factor (BDNF) signaling pathway; Common pathways underlying drug addiction; Mitochondrial gene expression; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; CAMKK2 pathway; Neuroinflammation and glutamatergic signaling; Hippocampal synaptogenesis and neurogenesis; Calcium regulation in cardiac cells" "Transcriptional activation of mitochondrial biogenesis; Regulation of MECP2 expression and activity; Negative regulation of NMDA receptor-mediated neuronal transmission; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde; Loss of phosphorylation of MECP2 at T308" "17" "0" "1.123" "1.149" "0.937" "0.999" "0.851" "0.803" "0.891" "0.736" "0.661" "224.2" "251.8" "257.5" "210.1" "224.0" "190.7" "180.0" "199.8" "165.1" "148.1" "" "" "" "" "" "" "" "" "" "" "118.7" "139.6" "147.4" "96.8" "121.2" "106.1" "105.9" "109.0" "92.6" "148.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4846678346596657924" "False" "Medium" "IsMasterProtein" "Q7L775" "EPM2A-interacting protein 1 OS=Homo sapiens OX=9606 GN=EPM2AIP1 PE=1 SV=1" "0.014" "False" "1.968" "1" "1" "1" "1" "607" "70.3" "6.11" "2.76" "1" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf18658" "9852" "ENSG00000178567" "EPM2AIP1" "hsa:9852; O94866; Q7L775; Q9H3L3" "" "" "0" "0" "1.141" "1.103" "0.981" "1.127" "1.143" "1.086" "0.982" "1.083" "1.264" "125.6" "143.3" "138.5" "123.2" "141.6" "143.5" "136.4" "123.4" "136.1" "158.8" "" "" "" "" "" "" "" "" "" "" "66.5" "79.5" "79.3" "56.8" "76.6" "79.8" "80.3" "67.4" "76.3" "158.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1988329424413395185" "False" "Medium" "IsMasterProtein" "Q8WVK7" "Spindle and kinetochore-associated protein 2 OS=Homo sapiens OX=9606 GN=SKA2 PE=1 SV=1" "0.014" "False" "1.966" "6" "1" "2" "1" "121" "14.2" "7.33" "4.42" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf16740" "348235" "ENSG00000182628" "SKA2" "A6NIL3; B3KPL3; E9PCB8; hsa:348235; Q8WVK7" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1157936408086935804" "False" "Medium" "IsMasterProtein" "O75446" "Histone deacetylase complex subunit SAP30 OS=Homo sapiens OX=9606 GN=SAP30 PE=1 SV=1" "0.014" "False" "1.966" "3" "1" "1" "1" "220" "23.3" "9.17" "2.17" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13866, Pf13867" "8819" "ENSG00000164105" "SAP30" "D3DP38; hsa:8819; O75446" "Retinoblastoma gene in cancer; Notch signaling pathway" "Potential therapeutics for SARS; HDACs deacetylate histones; NoRC negatively regulates rRNA expression" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7159093635266280091" "False" "Medium" "IsMasterProtein" "O95295" "SNARE-associated protein Snapin OS=Homo sapiens OX=9606 GN=SNAPIN PE=1 SV=1" "0.014" "False" "1.966" "5" "1" "1" "1" "136" "14.9" "9.31" "2.56" "1" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf14712" "23557" "ENSG00000143553" "SNAPIN" "D3DV56; hsa:23557; O95295; Q5SXU8" "Alstrom syndrome" "Golgi Associated Vesicle Biogenesis" "2" "0" "1.227" "1.166" "1.129" "1.038" "1.121" "1.025" "1.102" "1.063" "0.886" "89.5" "109.8" "104.3" "101.1" "92.9" "100.3" "91.8" "98.6" "95.1" "79.3" "" "" "" "" "" "" "" "" "" "" "47.4" "60.9" "59.8" "46.5" "50.3" "55.8" "54.0" "53.8" "53.4" "79.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2687201697740038391" "False" "Medium" "IsMasterProtein" "Q9NP92" "Large ribosomal subunit protein mL65 OS=Homo sapiens OX=9606 GN=MRPS30 PE=1 SV=2" "0.014" "False" "1.965" "2" "1" "1" "1" "439" "50.3" "7.97" "2.77" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf07147" "10884" "ENSG00000112996" "MRPS30" "hsa:10884; Q96I91; Q96Q19; Q9H0P8; Q9NP92; Q9NSF9; Q9NZ76" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.892" "0.962" "1.007" "0.953" "0.992" "0.919" "0.801" "0.765" "1.596" "195.1" "174.0" "187.8" "196.5" "186.0" "193.6" "179.4" "156.4" "149.2" "311.5" "" "" "" "" "" "" "" "" "" "" "103.3" "96.5" "107.6" "90.5" "100.6" "107.7" "105.6" "85.4" "83.7" "311.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5388836657935240768" "False" "Medium" "IsMasterProtein" "Q12872" "Splicing factor, suppressor of white-apricot homolog OS=Homo sapiens OX=9606 GN=SFSWAP PE=1 SV=3" "0.014" "False" "1.964" "1" "1" "1" "1" "951" "104.8" "8.05" "2.68" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf01805, Pf09750" "6433" "ENSG00000061936" "SFSWAP" "B2RN45; B7ZM97; F5H6B8; hsa:6433; Q12872; Q6PJF7" "mRNA processing" "" "1" "0" "1.011" "0.902" "1.141" "1.171" "0.944" "1.596" "1.718" "1.636" "1.587" "115.5" "116.7" "104.2" "131.8" "135.2" "109.1" "184.3" "198.4" "189.0" "183.3" "" "" "" "" "" "" "" "" "" "" "61.2" "64.7" "59.6" "60.7" "73.2" "60.7" "108.5" "108.3" "106.0" "183.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8312562393160644927" "False" "Medium" "IsMasterProtein" "Q8WV22" "Non-structural maintenance of chromosomes element 1 homolog OS=Homo sapiens OX=9606 GN=NSMCE1 PE=1 SV=5" "0.014" "False" "1.964" "3" "1" "1" "1" "266" "30.8" "7.47" "2.05" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf07574, Pf08746" "197370" "ENSG00000169189" "NSMCE1" "D3DWF6; hsa:197370; Q8WV22; Q9P045; Q9P049" "" "SUMOylation of DNA damage response and repair proteins" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5364611794781451874" "False" "Medium" "IsMasterProtein" "P08575" "Receptor-type tyrosine-protein phosphatase C OS=Homo sapiens OX=9606 GN=PTPRC PE=1 SV=3" "0.014" "False" "1.960" "1" "1" "1" "1" "1306" "147.4" "6.15" "0.00" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00041, Pf00102, Pf12453, Pf12567" "5788" "ENSG00000081237; ENSG00000262418" "PTPRC" "A0A0A0MT22; A8K7W6; hsa:5788; P08575; Q16614; Q9H0Y6; X6R433" "B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Regulatory circuits of the STAT3 signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2; EPO receptor signaling; Interferon type I signaling pathways" "Neutrophil degranulation; Phosphorylation of CD3 and TCR zeta chains; Other semaphorin interactions" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1395564513229487982" "False" "Medium" "IsMasterProtein" "O94826" "Mitochondrial import receptor subunit TOM70 OS=Homo sapiens OX=9606 GN=TOMM70 PE=1 SV=1" "0.014" "False" "1.953" "1" "1" "1" "1" "608" "67.4" "7.12" "2.64" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00515, Pf13181" "9868" "ENSG00000154174" "TOMM70" "D3DN48; hsa:9868; O94826" "Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "Ub-specific processing proteases; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Mitochondrial protein import; DDX58/IFIH1-mediated induction of interferon-alpha/beta; SARS-CoV-1 activates/modulates innate immune responses; PINK1-PRKN Mediated Mitophagy" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5658757101665122516" "False" "Medium" "IsMasterProtein" "Q9ULP9" "TBC1 domain family member 24 OS=Homo sapiens OX=9606 GN=TBC1D24 PE=1 SV=2" "0.014" "False" "1.946" "1" "1" "1" "1" "559" "62.9" "7.36" "3.00" "1" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity" "Pf00566, Pf07534" "57465" "ENSG00000162065" "TBC1D24" "A0JNW3; B9A6M6; hsa:57465; Q2KJ08; Q9ULP9" "" "TBC/RABGAPs" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3539568279205584801" "False" "Medium" "IsMasterProtein" "P57764" "Gasdermin-D OS=Homo sapiens OX=9606 GN=GSDMD PE=1 SV=1" "0.014" "False" "1.945" "1" "1" "1" "1" "484" "52.8" "5.08" "2.67" "1" "cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "transporter activity;other molecular function" "Pf04598, Pf17708" "79792" "ENSG00000104518; ENSG00000278718" "GSDMD" "A8K702; D3DWJ9; hsa:79792; P57764; Q96Q98" "STING pathway in Kawasaki-like disease and COVID-19" "Neutrophil degranulation; Purinergic signaling in leishmaniasis infection; Pyroptosis; Interleukin-1 processing; Regulation of TLR by endogenous ligand; Release of apoptotic factors from the mitochondria" "7" "0" "1.063" "1.080" "0.920" "1.100" "1.045" "0.948" "0.682" "1.088" "3.814" "117.0" "124.4" "126.3" "107.6" "128.8" "122.3" "110.9" "79.8" "127.3" "446.2" "" "" "" "" "" "" "" "" "" "" "61.9" "69.0" "72.3" "49.6" "69.7" "68.0" "65.3" "43.6" "71.4" "446.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2751742477750142499" "False" "Medium" "IsMasterProtein" "Q15345" "Leucine-rich repeat-containing protein 41 OS=Homo sapiens OX=9606 GN=LRRC41 PE=1 SV=3" "0.014" "False" "1.941" "1" "1" "1" "1" "812" "88.6" "8.38" "2.28" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "" "10489" "ENSG00000132128" "LRRC41" "A8K5G8; hsa:10489; Q15345; Q3MJ96; Q5TDF5; Q71RA8; Q9BSM0" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; RHOBTB3 ATPase cycle" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7515623990102163669" "False" "Medium" "IsMasterProtein" "P51161" "Gastrotropin OS=Homo sapiens OX=9606 GN=FABP6 PE=1 SV=2" "0.014" "False" "1.933" "7" "1" "1" "1" "128" "14.4" "6.80" "2.17" "1" "other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf14651" "2172" "ENSG00000170231" "FABP6" "hsa:2172; P51161; Q07DR7; Q8TBI3; Q9UGI7" "PPAR signaling pathway; Fatty acid transporters" "Triglyceride catabolism; Recycling of bile acids and salts; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis" "5" "0" "1.029" "0.971" "1.006" "1.038" "1.037" "0.978" "1.058" "0.890" "0.993" "335.3" "345.2" "325.4" "337.5" "348.0" "347.8" "328.1" "354.6" "298.5" "333.1" "" "" "" "" "" "" "" "" "" "" "177.6" "191.4" "186.4" "155.4" "188.3" "193.5" "193.1" "193.6" "167.4" "333.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5621842442587442909" "False" "Medium" "IsMasterProtein" "Q6ZNA5" "Ferric-chelate reductase 1 OS=Homo sapiens OX=9606 GN=FRRS1 PE=1 SV=2" "0.014" "False" "1.928" "1" "1" "1" "1" "592" "66.1" "7.47" "2.37" "1" "other biological processes" "other membranes" "other molecular function" "Pf02014, Pf03351" "391059" "ENSG00000156869" "FRRS1" "A6NLN7; hsa:391059; Q6ZNA5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4744508132045603899" "False" "Medium" "IsMasterProtein" "Q9BZG8" "2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 OS=Homo sapiens OX=9606 GN=DPH1 PE=1 SV=3" "0.014" "False" "1.924" "2" "1" "1" "1" "438" "48.1" "7.84" "2.43" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01866" "1801" "ENSG00000108963" "DPH1" "A0A6Q8JGF9; D3DTI3; hsa:1801; Q16439; Q4VBA2; Q9BTW7; Q9BZG8; Q9UCY0" "" "Synthesis of diphthamide-EEF2" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-303142054863253165" "False" "Medium" "IsMasterProtein" "Q67FW5" "Queuosine-tRNA galactosyltransferase OS=Homo sapiens OX=9606 GN=B3GNTL1 PE=1 SV=3" "0.014" "False" "1.923" "2" "1" "1" "1" "346" "39.4" "7.78" "2.34" "1" "" "" "other molecular function" "Pf00535" "146712" "ENSG00000175711; ENSG00000277033" "B3GNTL1" "hsa:146712; Q67FW5; Q6GV30; Q8WUT3" "" "O-linked glycosylation of mucins" "1" "0" "0.984" "1.022" "1.156" "1.078" "1.077" "1.202" "0.997" "1.151" "0.817" "104.6" "102.9" "106.9" "120.8" "112.7" "112.6" "125.7" "104.3" "120.3" "85.4" "" "" "" "" "" "" "" "" "" "" "55.4" "57.1" "61.2" "55.6" "61.0" "62.6" "74.0" "56.9" "67.5" "85.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8767729618822811067" "False" "Medium" "IsMasterProtein" "O14933" "Ubiquitin/ISG15-conjugating enzyme E2 L6 OS=Homo sapiens OX=9606 GN=UBE2L6 PE=1 SV=4" "0.014" "False" "1.923" "5" "1" "1" "1" "153" "17.8" "7.88" "2.29" "1" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "9246" "ENSG00000156587" "UBE2L6" "A6NDM6; A8MY53; hsa:9246; O14933; Q8N5D8; Q9UEZ0" "Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway; 7q11.23 copy number variation syndrome" "Antigen processing: Ubiquitination & Proteasome degradation; RSV-host interactions; Amyloid fiber formation; PKR-mediated signaling; ISG15 antiviral mechanism; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8563010740913614584" "False" "Medium" "IsMasterProtein" "Q96EB6" "NAD-dependent protein deacetylase sirtuin-1 OS=Homo sapiens OX=9606 GN=SIRT1 PE=1 SV=2" "0.014" "False" "1.923" "1" "1" "1" "1" "747" "81.6" "4.67" "2.79" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02146" "23411" "ENSG00000096717" "SIRT1" "hsa:23411; Q2XNF6; Q5JVQ0; Q96EB6; Q9GZR9; Q9Y6F0" "Androgen receptor signaling pathway; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Melatonin metabolism and effects; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Interactions between LOXL4 and oxidative stress pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Caloric restriction and aging; CAMKK2 pathway; 3q29 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Inclusion body myositis; Prostaglandin and leukotriene metabolism in senescence ; DYRK1A involvement regarding cell proliferation in brain development; Primary ovarian insufficiency; Prostaglandin and leukotriene metabolism in senescence ; 10q11.21q11.23 copy number variation syndrome; TAR syndrome; Omega-6-fatty acids in senescence" "Regulation of HSF1-mediated heat shock response; SIRT1 negatively regulates rRNA expression; Heme signaling; Circadian Clock; Regulation of FOXO transcriptional activity by acetylation" "27" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-946118222351064345" "False" "Medium" "IsMasterProtein" "Q6DD87" "Zinc finger protein 787 OS=Homo sapiens OX=9606 GN=ZNF787 PE=1 SV=4" "0.014" "False" "1.917" "2" "1" "1" "1" "382" "40.4" "7.96" "2.78" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13465, Pf13912" "126208" "ENSG00000142409" "ZNF787" "A0A087WUD1; hsa:126208; O00455; Q6DD87" "" "" "0" "0" "0.966" "1.005" "1.056" "0.961" "0.995" "1.142" "1.009" "0.991" "0.679" "225.4" "217.7" "226.5" "238.0" "216.6" "224.2" "257.4" "227.3" "223.4" "153.0" "" "" "" "" "" "" "" "" "" "" "119.3" "120.7" "129.7" "109.6" "117.2" "124.7" "151.5" "124.1" "125.3" "153.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6648624995345891134" "False" "Medium" "IsMasterProtein" "Q96T23" "Remodeling and spacing factor 1 OS=Homo sapiens OX=9606 GN=RSF1 PE=1 SV=2" "0.014" "False" "1.916" "0" "1" "1" "1" "1441" "163.7" "5.01" "2.15" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00628, Pf15612" "51773" "ENSG00000048649" "RSF1" "hsa:51773; Q86X86; Q96T23; Q9H3L8; Q9NVZ8; Q9NYU0" "" "Deposition of new CENPA-containing nucleosomes at the centromere" "1" "0" "1.070" "1.022" "1.567" "1.359" "1.088" "3.209" "2.675" "2.858" "1.015" "78.5" "84.0" "80.2" "123.0" "106.6" "85.3" "251.8" "209.9" "224.3" "79.7" "" "" "" "" "" "" "" "" "" "" "41.5" "46.6" "45.9" "56.6" "57.7" "47.5" "148.2" "114.6" "125.8" "79.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2668394544474588816" "False" "Medium" "IsMasterProtein" "Q99470" "Stromal cell-derived factor 2 OS=Homo sapiens OX=9606 GN=SDF2 PE=1 SV=2" "0.014" "False" "1.912" "4" "1" "2" "1" "211" "23.0" "7.33" "0.00" "1" "protein metabolism;other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf02815" "6388" "ENSG00000132581" "SDF2" "hsa:6388; Q99470; Q9BQ79" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1791941812365696393" "False" "Medium" "IsMasterProtein" "Q8WWF8" "Calcyphosin-like protein OS=Homo sapiens OX=9606 GN=CAPSL PE=1 SV=4" "0.014" "False" "1.911" "4" "1" "1" "1" "208" "24.2" "6.05" "2.04" "1" "" "other cell component" "other molecular function" "Pf13499" "133690" "ENSG00000152611" "CAPSL" "hsa:133690; Q8WWF8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2769087556665891581" "False" "Medium" "IsMasterProtein" "P35556" "Fibrillin-2 OS=Homo sapiens OX=9606 GN=FBN2 PE=1 SV=3" "0.014" "False" "1.902" "0" "1" "3" "1" "2912" "314.6" "4.86" "0.00" "1" "developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix" "signal transduction activity or receptor binding;extracellular structural activity;other molecular function" "Pf00683, Pf07645, Pf12661, Pf12662, Pf12947, Pf18193, Pf21364" "2201" "ENSG00000138829" "FBN2" "B4DU01; hsa:2201; P35556; Q59ES6" "Hypothesized pathways in pathogenesis of cardiovascular disease" "Degradation of the extracellular matrix; Molecules associated with elastic fibres" "4" "0" "0.861" "0.824" "0.819" "0.987" "0.713" "0.825" "0.964" "0.823" "0.459" "86.5" "74.5" "71.3" "70.9" "85.4" "61.6" "71.4" "83.4" "71.2" "39.7" "" "" "" "" "" "" "" "" "" "" "45.8" "41.3" "40.8" "32.6" "46.2" "34.3" "42.0" "45.5" "39.9" "39.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "545380139494389775" "False" "Medium" "IsMasterProtein" "P08962" "CD63 antigen OS=Homo sapiens OX=9606 GN=CD63 PE=1 SV=2" "0.014" "False" "1.900" "3" "1" "1" "1" "238" "25.6" "7.81" "0.00" "1" "cell adhesion;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component" "" "Pf00335" "967" "ENSG00000135404" "CD63" "F8VZE2; hsa:967; P08962; Q5TZP3; Q8N6Z9; Q9UCG6" "Extracellular vesicles in the crosstalk of cardiac cells; 11p11.2 copy number variation syndrome" "Neutrophil degranulation; Platelet degranulation" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9014625147701874173" "False" "Medium" "IsMasterProtein" "Q5T160" "Probable arginine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=RARS2 PE=1 SV=1" "0.014" "False" "1.894" "1" "1" "1" "1" "578" "65.5" "8.21" "2.56" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf00750, Pf05746" "57038" "ENSG00000146282" "RARS2" "B2RDT7; hsa:57038; Q5T160; Q96FU5; Q9H8K8" "" "Mitochondrial tRNA aminoacylation" "1" "0" "1.048" "1.091" "1.239" "1.046" "1.107" "1.024" "1.027" "1.003" "0.860" "61.6" "64.6" "67.2" "76.3" "64.5" "68.2" "63.1" "63.3" "61.8" "53.0" "" "" "" "" "" "" "" "" "" "" "32.6" "35.8" "38.5" "35.1" "34.9" "37.9" "37.1" "34.5" "34.7" "53.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5644554619979627576" "False" "Medium" "IsMasterProtein" "O75251" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS7 PE=1 SV=3" "0.014" "False" "1.891" "3" "1" "1" "1" "213" "23.5" "9.99" "2.46" "1" "cell organization and biogenesis;other metabolic processes;transport" "plasma membrane;other membranes;mitochondrion;other cell component" "transporter activity;other molecular function" "Pf01058" "374291" "ENSG00000115286" "NDUFS7" "B3KRI2; hsa:374291; O75251; Q2T9H7; Q9BV17" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "0.911" "1.085" "0.961" "0.928" "1.053" "1.011" "0.948" "1.013" "0.679" "268.9" "245.0" "291.9" "258.3" "249.5" "283.3" "271.8" "255.0" "272.5" "182.7" "" "" "" "" "" "" "" "" "" "" "142.4" "135.9" "167.2" "119.0" "135.0" "157.6" "160.0" "139.2" "152.9" "182.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3318503761924520630" "False" "Medium" "IsMasterProtein" "Q96R06" "Sperm-associated antigen 5 OS=Homo sapiens OX=9606 GN=SPAG5 PE=1 SV=2" "0.014" "False" "1.890" "1" "1" "1" "1" "1193" "134.3" "5.00" "2.12" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "" "10615" "ENSG00000076382" "SPAG5" "hsa:10615; O95213; Q96R06; Q9BWE8; Q9NT17; Q9UFE6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5646724778755280304" "False" "Medium" "IsMasterProtein" "Q8N6D5" "Ankyrin repeat domain-containing protein 29 OS=Homo sapiens OX=9606 GN=ANKRD29 PE=1 SV=2" "0.014" "False" "1.890" "3" "1" "1" "1" "301" "32.4" "9.41" "0.00" "1" "" "" "" "Pf12796" "147463" "ENSG00000154065" "ANKRD29" "B2R972; hsa:147463; Q6ZWE8; Q8N6D5; Q96LU9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5376837443182069511" "False" "Medium" "IsMasterProtein" "Q96M93" "Adenosine deaminase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ADAD1 PE=1 SV=1" "0.014" "False" "1.890" "1" "1" "1" "1" "576" "64.4" "9.01" "2.40" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf02137" "132612" "ENSG00000164113" "ADAD1" "A6NKN4; B7WPB0; D3DNX2; hsa:132612; Q8IWG6; Q8NA06; Q96M93" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6790579379401263319" "False" "Medium" "IsMasterProtein" "Q8IU85" "Calcium/calmodulin-dependent protein kinase type 1D OS=Homo sapiens OX=9606 GN=CAMK1D PE=1 SV=1" "0.014" "False" "1.889" "2" "1" "1" "1" "385" "42.9" "7.21" "2.36" "1" "other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "57118" "ENSG00000183049" "CAMK1D" "B0YIY0; hsa:57118; Q8IU85; Q9HD31" "" "" "0" "0" "0.956" "0.959" "1.093" "1.051" "1.007" "1.083" "0.883" "1.022" "3.785" "57.4" "54.9" "55.0" "62.7" "60.3" "57.8" "62.1" "50.7" "58.7" "217.2" "" "" "" "" "" "" "" "" "" "" "30.4" "30.4" "31.5" "28.9" "32.6" "32.2" "36.6" "27.7" "32.9" "217.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3813799245873050122" "False" "Medium" "IsMasterProtein" "Q96L91" "E1A-binding protein p400 OS=Homo sapiens OX=9606 GN=EP400 PE=1 SV=4" "0.014" "False" "1.889" "0" "1" "1" "1" "3159" "343.3" "9.19" "2.62" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf07529, Pf15790" "57634" "ENSG00000183495" "EP400" "hsa:57634; O15411; Q6P2F5; Q8N8Q7; Q8NE05; Q96JK7; Q96L91; Q9P230" "HDAC6 interactions in the central nervous system" "Formation of Senescence-Associated Heterochromatin Foci (SAHF); HATs acetylate histones" "4" "0" "1.481" "1.137" "1.328" "1.296" "1.213" "1.147" "0.982" "0.980" "2.686" "95.9" "142.1" "109.1" "127.4" "124.3" "116.3" "110.1" "94.2" "94.0" "257.7" "" "" "" "" "" "" "" "" "" "" "50.8" "78.8" "62.5" "58.7" "67.2" "64.7" "64.8" "51.4" "52.7" "257.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4714570572578111777" "False" "Medium" "IsMasterProtein" "Q86YS6" "Ras-related protein Rab-43 OS=Homo sapiens OX=9606 GN=RAB43 PE=1 SV=1" "0.014" "False" "1.889" "3" "1" "1" "1" "212" "23.3" "5.64" "2.82" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00071" "339122" "ENSG00000172780" "RAB43" "A8K4P9; E9PBQ0; hsa:339122; Q86YS6" "" "RAB geranylgeranylation; Retrograde transport at the Trans-Golgi-Network" "2" "0" "0.930" "0.988" "1.016" "1.009" "0.960" "1.060" "0.978" "1.108" "0.667" "169.6" "157.8" "167.5" "172.2" "171.2" "162.8" "179.7" "165.8" "187.9" "113.2" "" "" "" "" "" "" "" "" "" "" "89.8" "87.5" "95.9" "79.3" "92.6" "90.6" "105.7" "90.5" "105.4" "113.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2311185762453524816" "False" "Medium" "IsMasterProtein" "O95905" "Protein ecdysoneless homolog OS=Homo sapiens OX=9606 GN=ECD PE=1 SV=1" "0.014" "False" "1.884" "1" "1" "1" "1" "644" "72.7" "4.87" "1.94" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07093" "11319" "ENSG00000122882" "ECD" "C9JX46; E9PAW8; hsa:11319; O95905" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2674903910452323881" "False" "Medium" "IsMasterProtein" "Q9UQM7" "Calcium/calmodulin-dependent protein kinase type II subunit alpha OS=Homo sapiens OX=9606 GN=CAMK2A PE=1 SV=2" "0.014" "False" "1.879" "2" "1" "1" "1" "478" "54.1" "7.08" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf08332" "815" "ENSG00000070808" "CAMK2A" "hsa:815; Q9UL21; Q9UQM7; Q9Y2H4; Q9Y352" "B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Melatonin metabolism and effects; MECP2 and associated Rett syndrome; NO/cGMP/PKG mediated neuroprotection; Phosphodiesterases in neuronal function; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Ciliary landscape; EGF/EGFR signaling pathway; Fragile X syndrome; Disruption of postsynaptic signaling by CNV; Neuroinflammation and glutamatergic signaling; Hippocampal synaptogenesis and neurogenesis; Cardiomyocyte signaling pathways converging on titin; Calcium regulation in cardiac cells; ErbB signaling pathway" "Signaling by BRAF and RAF1 fusions; RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Regulation of MECP2 expression and activity; Assembly and cell surface presentation of NMDA receptors; Ion homeostasis; Ion transport by P-type ATPases; Interferon gamma signaling; Ca2+ pathway; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; Phase 0 - rapid depolarisation; HSF1-dependent transactivation; CaMK IV-mediated phosphorylation of CREB" "41" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6594093010420554285" "False" "Medium" "IsMasterProtein" "Q9NWZ3" "Interleukin-1 receptor-associated kinase 4 OS=Homo sapiens OX=9606 GN=IRAK4 PE=1 SV=1" "0.014" "False" "1.879" "2" "1" "1" "1" "460" "51.5" "5.41" "2.32" "1" "other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf07714" "51135" "ENSG00000198001" "IRAK4" "hsa:51135; Q69FE1; Q8TDF7; Q9NWZ3; Q9Y589" "IL-1 signaling pathway; AGE/RAGE pathway; Interleukin-1 (IL-1) structural pathway; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Fibrin complement receptor 3 signaling pathway; miRNA role in immune response in sepsis; LTF danger signal response pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Measles virus infection; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Toll-like receptor signaling pathway" "Interleukin-1 signaling; PIP3 activates AKT signaling; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; IRAK4 deficiency (TLR2/4); PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation; MyD88 cascade initiated on plasma membrane; IRAK4 deficiency (TLR5); TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "23" "0" "1.012" "0.996" "0.977" "0.854" "1.124" "1.148" "0.523" "0.981" "4.534" "57.6" "58.3" "57.3" "56.3" "49.2" "64.7" "66.1" "30.1" "56.5" "261.2" "" "" "" "" "" "" "" "" "" "" "30.5" "32.3" "32.8" "25.9" "26.6" "36.0" "38.9" "16.4" "31.7" "261.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7289415820017297402" "False" "Medium" "IsMasterProtein" "P82675" "Small ribosomal subunit protein uS5m OS=Homo sapiens OX=9606 GN=MRPS5 PE=1 SV=2" "0.014" "False" "1.878" "2" "1" "1" "1" "430" "48.0" "9.92" "2.15" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00333, Pf03719, Pf21251" "64969" "ENSG00000144029" "MRPS5" "hsa:64969; P82675; Q4ZFY5; Q96LJ6; Q9BWI4; Q9BYC4" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1467078136555344062" "False" "Medium" "IsMasterProtein" "Q8NHZ8" "Anaphase-promoting complex subunit CDC26 OS=Homo sapiens OX=9606 GN=CDC26 PE=1 SV=1" "0.014" "False" "1.878" "11" "1" "1" "1" "85" "9.8" "6.81" "1.92" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf10471" "246184" "ENSG00000176386" "CDC26" "hsa:246184; Q8NHZ8" "" "Separation of Sister Chromatids; Assembly of the pre-replicative complex; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "18" "0" "1.056" "0.993" "1.260" "1.033" "0.699" "1.061" "0.858" "0.802" "0.525" "37.9" "40.1" "37.7" "47.8" "39.2" "26.5" "40.2" "32.6" "30.4" "19.9" "" "" "" "" "" "" "" "" "" "" "20.1" "22.2" "21.6" "22.0" "21.2" "14.7" "23.7" "17.8" "17.1" "19.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3643630707960143102" "False" "Medium" "IsMasterProtein" "Q4KWH8" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 OS=Homo sapiens OX=9606 GN=PLCH1 PE=1 SV=1" "0.014" "False" "1.877" "0" "1" "2" "1" "1693" "189.1" "7.74" "3.85" "1" "other metabolic processes;transport;signal transduction" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00168, Pf00387, Pf00388, Pf09279, Pf16457" "23007" "ENSG00000114805" "PLCH1" "hsa:23007; Q29RV9; Q4KWH8; Q4KWH9; Q68CN0; Q86XK4; Q9H9U2; Q9UPT3" "Mesodermal commitment pathway; GPR40 pathway" "Synthesis of IP3 and IP4 in the cytosol" "3" "0" "1.243" "0.935" "0.988" "1.195" "1.074" "0.984" "0.888" "0.908" "1.033" "47.6" "59.2" "44.5" "47.1" "56.9" "51.1" "46.8" "42.3" "43.2" "49.2" "" "" "" "" "" "" "" "" "" "" "25.2" "32.8" "25.5" "21.7" "30.8" "28.4" "27.6" "23.1" "24.2" "49.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8399686422006739058" "False" "Medium" "IsMasterProtein" "O15116" "U6 snRNA-associated Sm-like protein LSm1 OS=Homo sapiens OX=9606 GN=LSM1 PE=1 SV=1" "0.014" "False" "1.876" "5" "1" "1" "1" "133" "15.2" "5.22" "2.52" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "27257" "ENSG00000175324" "LSM1" "B2R5E6; hsa:27257; O15116" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6208634135307330971" "False" "Medium" "IsMasterProtein" "P17480" "Nucleolar transcription factor 1 OS=Homo sapiens OX=9606 GN=UBTF PE=1 SV=1" "0.015" "False" "1.868" "1" "1" "1" "1" "764" "89.4" "5.81" "1.86" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00505, Pf09011, Pf14887" "7343" "ENSG00000108312" "UBTF" "A8K6R8; hsa:7343; P17480" "Ectoderm differentiation" "NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; RNA Polymerase I Promoter Opening" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "748867624032995252" "False" "Medium" "IsMasterProtein" "Q9H6S3" "Epidermal growth factor receptor kinase substrate 8-like protein 2 OS=Homo sapiens OX=9606 GN=EPS8L2 PE=1 SV=2" "0.015" "False" "1.867" "2" "1" "1" "1" "715" "80.6" "6.84" "0.00" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00018, Pf08416, Pf18016" "64787" "ENSG00000177106" "EPS8L2" "B3KSX1; B7ZKL3; hsa:64787; Q53GM8; Q8WYW7; Q96K06; Q9H6K9; Q9H6S3" "" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "2" "0" "1.193" "0.942" "1.584" "1.291" "0.906" "1.087" "1.018" "0.980" "1.705" "28.1" "33.5" "26.5" "44.5" "36.3" "25.5" "30.5" "28.6" "27.5" "47.9" "" "" "" "" "" "" "" "" "" "" "14.9" "18.6" "15.2" "20.5" "19.6" "14.2" "18.0" "15.6" "15.4" "47.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1889063708723088162" "False" "Medium" "IsMasterProtein" "O14772" "Fucose-1-phosphate guanylyltransferase OS=Homo sapiens OX=9606 GN=FPGT PE=1 SV=3" "0.015" "False" "1.867" "1" "1" "1" "1" "607" "68.0" "6.87" "1.79" "1" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf07959" "8790" "ENSG00000254685" "FPGT" "A0A0A0MRP2; A6NMH3; B4DRX2; B4E2Y7; E9PNQ2; hsa:8790; O14772; Q8N5J7" "" "GDP-fucose biosynthesis" "1" "0" "1.009" "0.873" "0.900" "0.943" "1.249" "0.936" "0.752" "0.717" "0.501" "78.3" "79.0" "68.3" "70.4" "73.8" "97.7" "73.2" "58.9" "56.2" "39.2" "" "" "" "" "" "" "" "" "" "" "41.4" "43.8" "39.1" "32.4" "39.9" "54.4" "43.1" "32.1" "31.5" "39.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2920922465256145671" "False" "Medium" "IsMasterProtein" "Q08AD1" "Calmodulin-regulated spectrin-associated protein 2 OS=Homo sapiens OX=9606 GN=CAMSAP2 PE=1 SV=3" "0.015" "False" "1.866" "0" "1" "1" "1" "1489" "168.0" "6.80" "0.00" "1" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi" "cytoskeletal activity;other molecular function" "Pf08683, Pf11971, Pf17095" "23271" "ENSG00000118200" "CAMSAP2" "B1APG6; hsa:23271; Q08AD1; Q08AD2; Q6PGN8; Q96FB3; Q9UG20; Q9UPS4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1583650821826420104" "False" "Medium" "IsMasterProtein" "Q9H9A5" "CCR4-NOT transcription complex subunit 10 OS=Homo sapiens OX=9606 GN=CNOT10 PE=1 SV=1" "0.015" "False" "1.864" "1" "1" "1" "1" "744" "82.3" "7.78" "2.35" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "" "25904" "ENSG00000182973; ENSG00000291502" "CNOT10" "B7Z7L1; F8WAF2; hsa:25904; Q9BU30; Q9H5J7; Q9H8X1; Q9H9A5; Q9H9W0; Q9HAH3; Q9UFJ2" "Ciliary landscape" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "4" "0" "1.025" "1.110" "1.241" "1.302" "1.094" "1.395" "1.166" "1.258" "2.366" "131.2" "134.5" "145.7" "162.9" "170.9" "143.6" "183.0" "153.0" "165.1" "310.5" "" "" "" "" "" "" "" "" "" "" "69.5" "74.6" "83.4" "75.0" "92.5" "79.9" "107.7" "83.5" "92.6" "310.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-699160270543076643" "False" "Medium" "IsMasterProtein" "Q14789" "Golgin subfamily B member 1 OS=Homo sapiens OX=9606 GN=GOLGB1 PE=1 SV=2" "0.015" "False" "1.861" "0" "1" "1" "1" "3259" "375.8" "5.00" "3.01" "1" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi" "nucleic acid binding activity" "" "2804" "ENSG00000173230" "GOLGB1" "B2ZZ91; D3DN92; E7EP74; F1T0J2; hsa:2804; Q14398; Q14789" "" "Golgi Associated Vesicle Biogenesis; COPI-mediated anterograde transport; Signaling by FLT3 fusion proteins" "3" "0" "1.086" "1.062" "1.099" "1.167" "0.935" "1.534" "1.818" "1.780" "1.226" "94.7" "102.9" "100.6" "104.1" "110.6" "88.6" "145.3" "172.2" "168.6" "116.1" "" "" "" "" "" "" "" "" "" "" "50.2" "57.0" "57.6" "48.0" "59.8" "49.3" "85.5" "94.0" "94.6" "116.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6736379060781022662" "False" "Medium" "IsMasterProtein" "P21399" "Cytoplasmic aconitate hydratase OS=Homo sapiens OX=9606 GN=ACO1 PE=1 SV=3" "0.015" "False" "1.860" "1" "1" "1" "1" "889" "98.3" "6.68" "2.61" "1" "other metabolic processes;transport;developmental processes;other biological processes" "cytosol;mitochondrion;ER/Golgi;other cell component" "nucleic acid binding activity;other molecular function" "Pf00330, Pf00694" "48" "ENSG00000122729" "ACO1" "D3DRK7; hsa:48; P21399; Q14652; Q5VZA7" "Iron metabolism in placenta; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc)" "Iron uptake and transport" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7919741535000260072" "False" "Medium" "IsMasterProtein" "Q96K80" "Zinc finger CCCH domain-containing protein 10 OS=Homo sapiens OX=9606 GN=ZC3H10 PE=1 SV=1" "0.015" "False" "1.857" "2" "1" "1" "1" "434" "46.0" "7.64" "1.64" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608" "84872" "ENSG00000135482" "ZC3H10" "hsa:84872; Q96K80" "" "" "0" "0" "0.902" "1.183" "1.308" "0.934" "0.949" "1.008" "0.993" "0.773" "0.636" "60.4" "54.5" "71.5" "79.0" "56.4" "57.3" "60.9" "60.0" "46.7" "38.4" "" "" "" "" "" "" "" "" "" "" "32.0" "30.2" "40.9" "36.4" "30.5" "31.9" "35.8" "32.7" "26.2" "38.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7187364612041296451" "False" "Medium" "IsMasterProtein" "Q96Q05" "Trafficking protein particle complex subunit 9 OS=Homo sapiens OX=9606 GN=TRAPPC9 PE=1 SV=2" "0.015" "False" "1.854" "1" "1" "1" "1" "1148" "128.4" "6.62" "1.81" "1" "cell organization and biogenesis;transport;developmental processes" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf08626" "83696" "ENSG00000167632" "TRAPPC9" "hsa:83696; Q4VTT3; Q658K7; Q6P149; Q6ZQT3; Q7L5C4; Q86Y21; Q96Q05; Q96SL2; Q9BQA2" "" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "2" "0" "1.386" "1.223" "1.505" "1.434" "1.126" "1.186" "1.109" "1.117" "1.498" "35.7" "49.5" "43.7" "53.8" "51.2" "40.2" "42.4" "39.6" "39.9" "53.5" "" "" "" "" "" "" "" "" "" "" "18.9" "27.4" "25.0" "24.8" "27.7" "22.4" "24.9" "21.6" "22.4" "53.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2965496322835630432" "False" "Medium" "IsMasterProtein" "Q9NYM9" "BET1-like protein OS=Homo sapiens OX=9606 GN=BET1L PE=1 SV=1" "0.015" "False" "1.854" "7" "1" "1" "1" "111" "12.4" "8.16" "2.31" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "" "51272" "ENSG00000177951" "BET1L" "B3KMY0; hsa:51272; Q9NYM9" "" "Intra-Golgi traffic; COPI-mediated anterograde transport" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6097346577725364269" "False" "Medium" "IsMasterProtein" "Q9UJ78" "Zinc finger MYM-type protein 5 OS=Homo sapiens OX=9606 GN=ZMYM5 PE=1 SV=4" "0.015" "False" "1.849" "1" "1" "1" "1" "669" "74.8" "8.16" "2.47" "1" "other biological processes" "nucleus" "other molecular function" "Pf06467" "9205" "ENSG00000132950" "ZMYM5" "B2R6V1; hsa:9205; Q5T6E1; Q5T6E2; Q5T6E4; Q96IY6; Q9NZY5; Q9UBW0; Q9UJ77; Q9UJ78" "" "" "0" "0" "1.094" "0.953" "0.976" "1.062" "1.007" "0.941" "1.062" "1.043" "1.362" "143.7" "157.1" "137.0" "140.2" "152.6" "144.7" "135.2" "152.6" "149.8" "195.7" "" "" "" "" "" "" "" "" "" "" "76.1" "87.1" "78.4" "64.6" "82.6" "80.5" "79.5" "83.3" "84.0" "195.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2424139350801194209" "False" "Medium" "IsMasterProtein" "Q9NRG0" "Chromatin accessibility complex protein 1 OS=Homo sapiens OX=9606 GN=CHRAC1 PE=1 SV=1" "0.015" "False" "1.849" "6" "1" "3" "1" "131" "14.7" "5.10" "6.43" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "54108" "ENSG00000104472" "CHRAC1" "hsa:54108; Q9NRG0" "Acute viral myocarditis" "" "1" "0" "1.149" "1.011" "0.901" "1.060" "0.803" "1.044" "0.966" "0.868" "0.833" "50.4" "57.9" "50.9" "45.4" "53.4" "40.5" "52.6" "48.6" "43.7" "42.0" "" "" "" "" "" "" "" "" "" "" "26.7" "32.1" "29.2" "20.9" "28.9" "22.5" "31.0" "26.6" "24.5" "42.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1217217274349295091" "False" "Medium" "IsMasterProtein" "Q9Y4E8" "Ubiquitin carboxyl-terminal hydrolase 15 OS=Homo sapiens OX=9606 GN=USP15 PE=1 SV=3" "0.015" "False" "1.844" "1" "1" "1" "1" "981" "112.3" "5.22" "2.27" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00443, Pf06337, Pf14533, Pf14836" "9958" "ENSG00000135655" "USP15" "hsa:9958; Q08AL5; Q9H8G9; Q9HCA6; Q9UNP0; Q9Y4E8; Q9Y5B5" "" "Ub-specific processing proteases; UCH proteinases; Downregulation of TGF-beta receptor signaling" "3" "0" "1.110" "1.093" "1.411" "1.003" "1.262" "1.219" "0.935" "1.165" "3.047" "66.4" "73.7" "72.6" "93.7" "66.6" "83.8" "80.9" "62.1" "77.4" "202.4" "" "" "" "" "" "" "" "" "" "" "35.2" "40.9" "41.6" "43.2" "36.0" "46.6" "47.6" "33.9" "43.4" "202.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4996953049836216410" "False" "Medium" "IsMasterProtein" "O14618" "Copper chaperone for superoxide dismutase OS=Homo sapiens OX=9606 GN=CCS PE=1 SV=1" "0.015" "False" "1.843" "3" "1" "1" "1" "274" "29.0" "5.58" "2.62" "1" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf00080, Pf00403" "9973" "ENSG00000173992" "CCS" "hsa:9973; O14618; Q2M366; Q8NEV0" "Amyotrophic lateral sclerosis (ALS); Copper homeostasis" "Detoxification of Reactive Oxygen Species" "3" "0" "1.027" "1.091" "1.027" "0.965" "1.012" "0.924" "1.036" "1.174" "1.050" "234.8" "241.0" "256.2" "241.0" "226.7" "237.5" "216.9" "243.3" "275.7" "246.6" "" "" "" "" "" "" "" "" "" "" "124.3" "133.6" "146.7" "111.0" "122.6" "132.1" "127.6" "132.8" "154.7" "246.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8152451809479341191" "False" "Medium" "IsMasterProtein" "A4UGR9" "Xin actin-binding repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=XIRP2 PE=1 SV=2" "0.015" "False" "1.839" "0" "1" "1" "1" "3374" "382.1" "6.38" "1.69" "1" "cell organization and biogenesis;developmental processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf08043" "129446" "ENSG00000163092" "XIRP2" "A0PJ94; A4UGR9; B2BBS0; B2BBS1; B2BBS4; B3KVH0; hsa:129446; J3KNB1; Q53R52; Q5MJ67; Q702N7; Q86T36; Q86T38; Q86T46; Q86T51; Q86T53; Q86T55; Q86T79; Q86TB6; Q8N1M9; Q8N3R5; Q8TBV6" "" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1936196132069053391" "False" "Medium" "IsMasterProtein" "Q8WXA9" "Splicing regulatory glutamine/lysine-rich protein 1 OS=Homo sapiens OX=9606 GN=SREK1 PE=1 SV=1" "0.015" "False" "1.838" "3" "1" "1" "1" "508" "59.3" "10.39" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00076" "140890" "ENSG00000153914" "SREK1" "A4FTW3; hsa:140890; Q2M1J0; Q86X37; Q8WXA9" "mRNA processing" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3530888468156294697" "False" "Medium" "IsMasterProtein" "O00541" "Pescadillo homolog OS=Homo sapiens OX=9606 GN=PES1 PE=1 SV=1" "0.015" "False" "1.838" "2" "1" "1" "1" "588" "68.0" "7.33" "0.00" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06732, Pf16589" "23481" "ENSG00000100029" "PES1" "hsa:23481; O00541; Q6IC29" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8417991388953307590" "False" "Medium" "IsMasterProtein" "O75064" "DENN domain-containing protein 4B OS=Homo sapiens OX=9606 GN=DENND4B PE=1 SV=4" "0.015" "False" "1.837" "1" "1" "1" "1" "1496" "163.7" "7.21" "2.67" "1" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity" "Pf02141, Pf03455, Pf03456" "9909" "ENSG00000198837" "DENND4B" "hsa:9909; O75064; Q5T4K0" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "0.989" "1.212" "1.414" "0.999" "1.006" "1.184" "1.129" "1.206" "0.945" "66.4" "65.7" "80.5" "93.9" "66.3" "66.8" "78.6" "75.0" "80.1" "62.7" "" "" "" "" "" "" "" "" "" "" "35.2" "36.4" "46.1" "43.3" "35.9" "37.2" "46.3" "40.9" "44.9" "62.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3564973388906415615" "False" "Medium" "IsMasterProtein" "Q96DY7" "Mdm2-binding protein OS=Homo sapiens OX=9606 GN=MTBP PE=1 SV=1" "0.015" "False" "1.837" "1" "1" "1" "1" "904" "102.1" "7.77" "2.59" "1" "cell cycle OR cell proliferation;other biological processes" "other cell component" "" "Pf14918, Pf14919, Pf14920" "27085" "ENSG00000172167" "MTBP" "B4DUR5; hsa:27085; Q96DY7; Q9HA89" "" "" "0" "0" "1.027" "0.884" "0.987" "1.084" "1.011" "1.040" "1.074" "0.994" "0.545" "287.0" "294.8" "253.8" "283.1" "311.0" "290.2" "298.3" "308.2" "285.2" "156.5" "" "" "" "" "" "" "" "" "" "" "152.0" "163.4" "145.3" "130.4" "168.2" "161.4" "175.6" "168.2" "160.0" "156.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1368746537246451603" "False" "Medium" "IsMasterProtein" "Q9Y2I8" "WD repeat-containing protein 37 OS=Homo sapiens OX=9606 GN=WDR37 PE=1 SV=2" "0.015" "False" "1.836" "1" "1" "1" "1" "494" "54.6" "7.23" "2.69" "1" "developmental processes;other biological processes" "nucleus;other cell component" "" "Pf00400" "22884" "ENSG00000047056" "WDR37" "A8K976; D3DRQ7; hsa:22884; Q5SW03; Q8WVG2; Q9NTJ6; Q9Y2I8" "" "" "0" "0" "0.961" "0.925" "1.078" "1.041" "0.946" "0.908" "0.824" "0.889" "1.004" "245.4" "235.9" "226.9" "264.6" "255.5" "232.1" "222.8" "202.3" "218.1" "246.3" "" "" "" "" "" "" "" "" "" "" "130.0" "130.8" "130.0" "121.9" "138.2" "129.1" "131.1" "110.4" "122.4" "246.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3535367266353514153" "False" "Medium" "IsMasterProtein" "O00160" "Unconventional myosin-If OS=Homo sapiens OX=9606 GN=MYO1F PE=1 SV=3" "0.015" "False" "1.833" "1" "1" "1" "1" "1098" "124.8" "9.11" "2.21" "1" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf00063, Pf06017" "4542" "ENSG00000142347" "MYO1F" "O00160; Q8WWN7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4492999109905159377" "False" "Medium" "IsMasterProtein" "Q15121" "Astrocytic phosphoprotein PEA-15 OS=Homo sapiens OX=9606 GN=PEA15 PE=1 SV=2" "0.015" "False" "1.832" "9" "1" "1" "1" "130" "15.0" "5.02" "2.02" "1" "transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf01335" "8682" "ENSG00000162734" "PEA15" "B1AKZ3; hsa:8682; O00511; Q15121" "Apoptosis modulation and signaling" "RAF/MAP kinase cascade; RAF-independent MAPK1/3 activation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7498907094133803237" "False" "Medium" "IsMasterProtein" "A4D1P6" "WD repeat-containing protein 91 OS=Homo sapiens OX=9606 GN=WDR91 PE=1 SV=2" "0.015" "False" "1.832" "2" "1" "1" "1" "747" "83.3" "6.58" "0.00" "1" "transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle" "enzyme regulator activity" "Pf00400, Pf12894" "29062" "ENSG00000105875" "WDR91" "A4D1P6; A6NK54; C9JMI4; hsa:29062; Q6FI65; Q6MZQ1; Q6P4I1; Q96AE5; Q96G63; Q9H062; Q9H9B6; Q9NVG7; Q9NZY6" "" "CDC42 GTPase cycle" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7128094865721745487" "False" "Medium" "IsMasterProtein" "Q9UKL6" "Phosphatidylcholine transfer protein OS=Homo sapiens OX=9606 GN=PCTP PE=1 SV=1" "0.015" "False" "1.830" "5" "1" "1" "1" "214" "24.8" "5.78" "0.00" "1" "transport;other biological processes" "cytosol" "transporter activity;other molecular function" "Pf01852" "58488" "ENSG00000141179" "PCTP" "hsa:58488; Q9BSC9; Q9UIT3; Q9UKL6; Q9UKW7" "" "Mitochondrial Fatty Acid Beta-Oxidation; Synthesis of PC" "2" "0" "1.086" "1.154" "1.204" "1.065" "1.143" "1.162" "1.218" "1.048" "0.777" "134.7" "146.2" "155.4" "162.1" "143.5" "153.9" "156.5" "164.0" "141.1" "104.7" "" "" "" "" "" "" "" "" "" "" "71.3" "81.1" "89.0" "74.7" "77.6" "85.6" "92.1" "89.5" "79.2" "104.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7033934706938727348" "False" "Medium" "IsMasterProtein" "Q9UNY4" "Transcription termination factor 2 OS=Homo sapiens OX=9606 GN=TTF2 PE=1 SV=2" "0.015" "False" "1.830" "1" "1" "1" "1" "1162" "129.5" "8.37" "2.33" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf06839" "8458" "ENSG00000116830" "TTF2" "A8K4Q2; hsa:8458; O75921; Q5T2K7; Q5VVU8; Q8N6I8; Q9UNY4" "Thyroid stimulating hormone (TSH) signaling pathway; Thyroid hormones production and peripheral downstream signaling effects" "" "2" "0" "1.074" "0.948" "0.968" "0.950" "1.054" "1.161" "0.756" "1.045" "3.777" "53.6" "57.6" "50.8" "51.9" "50.9" "56.5" "62.2" "40.5" "56.0" "202.4" "" "" "" "" "" "" "" "" "" "" "28.4" "31.9" "29.1" "23.9" "27.6" "31.4" "36.6" "22.1" "31.4" "202.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3062212909163771863" "False" "Medium" "IsMasterProtein" "P19838" "Nuclear factor NF-kappa-B p105 subunit OS=Homo sapiens OX=9606 GN=NFKB1 PE=1 SV=2" "0.015" "False" "1.829" "1" "1" "1" "1" "968" "105.3" "5.40" "2.26" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00023, Pf00531, Pf00554, Pf16179" "4790" "ENSG00000109320" "NFKB1" "A8K5Y5; B3KVE8; hsa:4790; P19838; Q68D84; Q86V43; Q8N4X7; Q9NZC0" "Osteopontin signaling; Selenium micronutrient network; Vitamin B12 metabolism; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Folate metabolism; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Neural crest differentiation; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Quercetin and Nf-kB / AP-1 induced apoptosis; PDGF pathway; Apoptosis; T cell receptor and co-stimulatory signaling; Aryl hydrocarbon receptor pathway; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; Selenium metabolism and selenoproteins; Apoptosis-related network due to altered Notch3 in ovarian cancer; IL1 and megakaryocytes in obesity; Myometrial relaxation and contraction pathways; Melatonin metabolism and effects; RAC1/PAK1/p38/MMP2 pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Photodynamic therapy-induced NF-kB survival signaling; NAD metabolism, sirtuins and aging; Hepatitis C and hepatocellular carcinoma; MAPK signaling pathway; Apoptosis modulation by HSP70; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; MYD88 distinct input-output pathway; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Oxidative damage response; IL-4 signaling pathway; miRNA regulation of prostate cancer signaling pathways; Prion disease pathway; NO/cGMP/PKG mediated neuroprotection; Oxidative stress response; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Non-genomic actions of 1,25 dihydroxyvitamin D3; Ciliary landscape; Nonalcoholic fatty liver disease; LTF danger signal response pathway; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Interactions between immune cells and microRNAs in tumor microenvironment; Canonical NF-kB pathway; Cancer immunotherapy by PD-1 blockade; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Aspirin and miRNAs; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; FGF23 signaling in hypophosphatemic rickets and related disorders; TGF-beta receptor signaling in skeletal dysplasias; Kisspeptin/kisspeptin receptor system in the ovary; Activation of NLRP3 inflammasome by SARS-CoV-2; Host-pathogen interaction of human coronaviruses - interferon induction; 16p11.2 proximal deletion syndrome; STING pathway in Kawasaki-like disease and COVID-19; RAS and bradykinin pathways in COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Modulators of TCR signaling and T cell activation; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Prostaglandin signaling; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Inclusion body myositis; Alzheimer's disease; Th17 cell differentiation pathway; Lung pathology of COVID-19; Ulcerative colitis signaling; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction; Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids; Inflammatory bowel disease signaling; Role of ROS in COVID-19 endothelial dysfunction; Genetic causes of porto-sinusoidal vascular disease; Acute myeloid leukemia; TROP2 regulatory signaling; Autophagy in pancreatic ductal adenocarcinoma; Macrophage-stimulating protein (MSP) signaling network map; Affected pathways in Duchenne muscular dystrophy; TAR syndrome; Osteoarthritic chondrocyte hypertrophy; 10q22q23 copy number variation; IL-19 signaling pathway; GNAQ pathways in port-wine stain; TGF-beta receptor signaling; Notch signaling pathway; T-cell receptor signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway; Toll-like receptor signaling pathway" "Neutrophil degranulation; FCERI mediated NF-kB activation; Downstream TCR signaling; Transcriptional regulation of white adipocyte differentiation; Activation of NF-kappaB in B cells; HCMV Early Events; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; PKMTs methylate histone lysines; RIP-mediated NFkB activation via ZBP1; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; SARS-CoV-1 activates/modulates innate immune responses; Regulation of NFE2L2 gene expression; CD209 (DC-SIGN) signaling; Interleukin-1 processing; CLEC7A/inflammasome pathway; Regulated proteolysis of p75NTR; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "151" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-973328225883047536" "False" "Medium" "IsMasterProtein" "Q8IV48" "3'-5' exoribonuclease 1 OS=Homo sapiens OX=9606 GN=ERI1 PE=1 SV=3" "0.015" "False" "1.829" "2" "1" "1" "1" "349" "40.0" "6.70" "2.62" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00929, Pf02037" "90459" "ENSG00000104626" "ERI1" "A8K4U7; hsa:90459; Q8IV48; Q9NSX3" "exRNA mechanism of action and biogenesis; 8p23.1 copy number variation syndrome; 4p16.3 copy number variation" "Major pathway of rRNA processing in the nucleolus and cytosol" "4" "0" "0.890" "0.809" "1.012" "1.060" "0.873" "0.950" "0.657" "0.953" "3.363" "174.8" "155.6" "141.4" "176.9" "185.3" "152.6" "166.1" "114.8" "166.7" "587.9" "" "" "" "" "" "" "" "" "" "" "92.6" "86.3" "81.0" "81.5" "100.2" "84.9" "97.8" "62.7" "93.5" "587.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9109513475254745228" "False" "Medium" "IsMasterProtein" "Q9UBD5" "Origin recognition complex subunit 3 OS=Homo sapiens OX=9606 GN=ORC3 PE=1 SV=1" "0.015" "False" "1.826" "1" "1" "1" "1" "711" "82.2" "7.61" "2.17" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf07034, Pf18137, Pf19675" "23595" "ENSG00000135336" "ORC3" "A2A2T5; B4E025; hsa:23595; Q13565; Q53GY6; Q5T159; Q6IUY7; Q86TN5; Q9UBD5; Q9UG44; Q9UNT6" "Cell cycle; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the ORC complex at the origin of replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; E2F-enabled inhibition of pre-replication complex formation; CDC6 association with the ORC:origin complex" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3230882669857741214" "False" "Medium" "IsMasterProtein" "Q6ZRP7" "Sulfhydryl oxidase 2 OS=Homo sapiens OX=9606 GN=QSOX2 PE=1 SV=3" "0.015" "False" "1.814" "2" "1" "1" "1" "698" "77.5" "7.72" "0.00" "1" "protein metabolism;other metabolic processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus" "other molecular function" "Pf00085, Pf04777, Pf18108, Pf18371" "169714" "ENSG00000165661" "QSOX2" "A2CEE0; A6NLB0; hsa:169714; Q5TB37; Q6ZRP7; Q7Z7B6; Q86VV7; Q8N3G2" "" "" "0" "0" "0.997" "0.999" "1.045" "1.005" "1.188" "0.968" "1.037" "1.176" "1.013" "161.1" "160.7" "161.0" "168.3" "161.9" "191.5" "156.0" "167.0" "189.6" "163.3" "" "" "" "" "" "" "" "" "" "" "85.3" "89.1" "92.2" "77.5" "87.6" "106.5" "91.8" "91.2" "106.3" "163.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3718906404474103384" "False" "Medium" "IsMasterProtein" "P19174" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 OS=Homo sapiens OX=9606 GN=PLCG1 PE=1 SV=1" "0.015" "False" "1.814" "1" "1" "1" "1" "1290" "148.4" "6.05" "0.00" "1" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018, Pf00168, Pf00169, Pf00387, Pf00388" "5335" "ENSG00000124181" "PLCG1" "B7ZLY7; B9EGH4; E1P5W4; hsa:5335; P19174; Q2V575" "Angiogenesis; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; PDGF pathway; Primary focal segmental glomerulosclerosis (FSGS); T cell receptor and co-stimulatory signaling; Myometrial relaxation and contraction pathways; Kit receptor signaling pathway; MFAP5-mediated ovarian cancer cell motility and invasiveness; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; GPR40 pathway; PDGFR-beta pathway; MET in type 1 papillary renal cell carcinoma; Ras signaling; Non-small cell lung cancer; EGF/EGFR signaling pathway; Resistin as a regulator of inflammation; Fragile X syndrome; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; mBDNF and proBDNF regulation of GABA neurotransmission; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Th17 cell differentiation pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis; GDNF signaling; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; 5q35 copy number variation; ErbB signaling pathway; T-cell receptor signaling pathway" "ISG15 antiviral mechanism; Generation of second messenger molecules; Role of phospholipids in phagocytosis; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Signaling by ALK fusions and activated point mutants; RET signaling; Downstream signal transduction; Signaling by ALK; DAP12 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; EGFR interacts with phospholipase C-gamma; Signaling by FGFR1 in disease; Synthesis of IP3 and IP4 in the cytosol; Phospholipase C-mediated cascade: FGFR1; Phospholipase C-mediated cascade; FGFR2; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Phospholipase C-mediated cascade; FGFR3; Phospholipase C-mediated cascade; FGFR4; Signaling by FGFR3 in disease; DAG and IP3 signaling; Erythropoietin activates Phospholipase C gamma (PLCG); Role of second messengers in netrin-1 signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; PLCG1 events in ERBB2 signaling; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR4 in disease; PLC-gamma1 signalling; PECAM1 interactions; Activated NTRK2 signals through PLCG1; Activated NTRK3 signals through PLCG1" "76" "0" "0.981" "0.970" "1.354" "1.015" "0.837" "1.078" "1.079" "1.129" "1.360" "48.4" "47.4" "46.9" "65.5" "49.1" "40.5" "52.2" "52.2" "54.6" "65.8" "" "" "" "" "" "" "" "" "" "" "25.6" "26.3" "26.9" "30.2" "26.6" "22.5" "30.7" "28.5" "30.6" "65.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6803937283949644789" "False" "Medium" "IsMasterProtein" "O15381" "Nuclear valosin-containing protein-like OS=Homo sapiens OX=9606 GN=NVL PE=1 SV=1" "0.015" "False" "1.810" "1" "1" "1" "1" "856" "95.0" "6.48" "2.16" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00004, Pf16725, Pf17862" "4931" "ENSG00000143748" "NVL" "B4DMC4; B4DP98; hsa:4931; O15381; Q96EM7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2256308892199755457" "False" "Medium" "IsMasterProtein" "Q969J3" "BLOC-1-related complex subunit 5 OS=Homo sapiens OX=9606 GN=BORCS5 PE=1 SV=1" "0.015" "False" "1.808" "4" "1" "1" "1" "196" "22.2" "6.35" "3.30" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf10158" "118426" "ENSG00000165714; ENSG00000280689" "BORCS5" "hsa:118426; Q969J3; Q96QS5" "" "" "0" "0" "0.910" "0.999" "0.947" "1.086" "1.045" "0.969" "1.059" "1.003" "0.885" "321.7" "292.6" "321.4" "304.6" "349.4" "336.3" "311.6" "340.7" "322.7" "284.8" "" "" "" "" "" "" "" "" "" "" "170.3" "162.2" "184.1" "140.3" "189.0" "187.1" "183.4" "186.0" "181.0" "284.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9003778122824522310" "False" "Medium" "IsMasterProtein" "Q9BRT3" "Migration and invasion enhancer 1 OS=Homo sapiens OX=9606 GN=MIEN1 PE=1 SV=1" "0.015" "False" "1.805" "6" "1" "1" "1" "115" "12.4" "4.37" "2.88" "1" "other biological processes" "plasma membrane;other membranes;cytosol" "" "Pf10262" "84299" "ENSG00000141741" "MIEN1" "hsa:84299; Q9BRT3" "17q12 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3767865638315377274" "False" "Medium" "IsMasterProtein" "O60684" "Importin subunit alpha-7 OS=Homo sapiens OX=9606 GN=KPNA6 PE=1 SV=1" "0.015" "False" "1.805" "2" "1" "1" "1" "536" "60.0" "4.98" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "23633" "ENSG00000025800" "KPNA6" "B2RDC7; D3DPP5; hsa:23633; O60684; Q5VVU3" "" "Assembly of the ORC complex at the origin of replication" "1" "0" "1.106" "1.051" "1.911" "1.182" "0.908" "1.516" "0.970" "1.022" "2.604" "36.3" "40.2" "38.2" "69.4" "42.9" "33.0" "55.1" "35.2" "37.1" "94.6" "" "" "" "" "" "" "" "" "" "" "19.2" "22.3" "21.9" "32.0" "23.2" "18.4" "32.4" "19.2" "20.8" "94.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-879380199029803556" "False" "Medium" "IsMasterProtein" "Q9ULV0" "Unconventional myosin-Vb OS=Homo sapiens OX=9606 GN=MYO5B PE=1 SV=3" "0.015" "False" "1.803" "1" "1" "1" "1" "1848" "213.5" "7.20" "0.00" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf00612, Pf01843" "4645" "ENSG00000167306" "MYO5B" "B0I1R3; hsa:4645; Q0P656; Q9H6Y6; Q9ULV0" "Alstrom syndrome" "Vasopressin regulates renal water homeostasis via Aquaporins" "2" "0" "0.953" "0.958" "1.319" "0.927" "1.061" "1.179" "0.853" "0.830" "0.738" "88.6" "84.4" "84.9" "116.8" "82.1" "93.9" "104.5" "75.6" "73.5" "65.4" "" "" "" "" "" "" "" "" "" "" "46.9" "46.8" "48.6" "53.8" "44.4" "52.3" "61.5" "41.3" "41.3" "65.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1822880503447006764" "False" "Medium" "IsMasterProtein" "Q9NX04" "AFG2-interacting ribosome maturation factor OS=Homo sapiens OX=9606 GN=AIRIM PE=1 SV=1" "0.015" "False" "1.803" "4" "1" "1" "1" "203" "23.4" "5.67" "2.32" "1" "other biological processes" "cytosol;nucleus;other cell component" "" "Pf15011" "54955" "ENSG00000116922" "AIRIM" "D3DPT1; Q8WVD1; Q9NX04" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5479231618500312272" "False" "Medium" "IsMasterProtein" "Q8NF91" "Nesprin-1 OS=Homo sapiens OX=9606 GN=SYNE1 PE=1 SV=4" "0.015" "False" "1.798" "0" "1" "1" "1" "8797" "1010.5" "5.53" "2.93" "1" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf10541" "23345" "ENSG00000131018" "SYNE1" "B3W695; E7EQI5; H0Y4C0; O94890; Q3ZCV0; Q5JV19; Q5JV22; Q8N9P7; Q8NF91; Q8TCP1; Q8WWW6; Q8WWW7; Q8WXF6; Q96N17; Q9C0A7; Q9H525; Q9H526; Q9NS36; Q9NU50; Q9UJ06; Q9UJ07; Q9ULF8" "Envelope proteins and their potential roles in EDMD physiopathology" "Meiotic synapsis" "2" "0" "1.052" "1.120" "1.243" "1.039" "0.980" "1.069" "1.107" "0.992" "0.566" "281.6" "296.1" "315.3" "349.8" "292.7" "275.9" "300.9" "311.8" "279.2" "159.2" "" "" "" "" "" "" "" "" "" "" "149.1" "164.2" "180.6" "161.1" "158.3" "153.5" "177.1" "170.2" "156.6" "159.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8049844811418031107" "False" "Medium" "IsMasterProtein" "O95707" "Ribonuclease P protein subunit p29 OS=Homo sapiens OX=9606 GN=POP4 PE=1 SV=2" "0.015" "False" "1.794" "4" "1" "1" "1" "220" "25.4" "10.07" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01868" "10775" "ENSG00000105171" "POP4" "hsa:10775; O95707; Q5XKL7; Q6FHW9; Q9UQQ3" "" "tRNA processing in the nucleus" "1" "0" "1.120" "0.746" "1.004" "1.168" "0.877" "0.964" "0.806" "0.876" "0.831" "46.2" "51.8" "34.5" "46.5" "54.0" "40.6" "44.6" "37.3" "40.5" "38.4" "" "" "" "" "" "" "" "" "" "" "24.5" "28.7" "19.8" "21.4" "29.2" "22.6" "26.2" "20.3" "22.7" "38.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3845520029655765588" "False" "Medium" "IsMasterProtein" "Q9P2G1" "Ankyrin repeat and IBR domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ANKIB1 PE=1 SV=3" "0.015" "False" "1.793" "1" "1" "1" "1" "1089" "121.9" "5.11" "0.00" "1" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf00023, Pf01485, Pf12796, Pf19422" "54467" "ENSG00000001629" "ANKIB1" "hsa:54467; Q6GMS4; Q6P3S9; Q9NTD7; Q9NW49; Q9P2G1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2707692795518285071" "False" "Medium" "IsMasterProtein" "Q567U6" "Coiled-coil domain-containing protein 93 OS=Homo sapiens OX=9606 GN=CCDC93 PE=1 SV=2" "0.015" "False" "1.790" "1" "1" "1" "1" "631" "73.2" "8.15" "2.03" "1" "transport" "other cytoplasmic organelle;other cell component" "" "Pf09762, Pf21673" "54520" "ENSG00000125633" "CCDC93" "A8K3V7; hsa:54520; Q4LE78; Q53TJ2; Q567U6; Q8TBX5; Q9H6R5; Q9NV15" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6403142608945012148" "False" "Medium" "IsMasterProtein" "Q8IX01" "SURP and G-patch domain-containing protein 2 OS=Homo sapiens OX=9606 GN=SUGP2 PE=1 SV=2" "0.015" "False" "1.789" "1" "1" "1" "1" "1082" "120.1" "7.28" "1.84" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf01585, Pf01805" "10147" "ENSG00000064607" "SUGP2" "C9JI71; hsa:10147; O15071; O60369; Q5JPH7; Q8IX01; Q8WUF7" "mRNA processing" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-658722355380059482" "False" "Medium" "IsMasterProtein" "Q9UPN4" "Centrosomal protein of 131 kDa OS=Homo sapiens OX=9606 GN=CEP131 PE=1 SV=3" "0.015" "False" "1.787" "1" "1" "1" "1" "1083" "122.1" "8.69" "2.44" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "22994" "ENSG00000141577" "CEP131" "A6NHI8; B2RN11; hsa:22994; Q96F50; Q9UPN4" "" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7781995361222793159" "False" "Medium" "IsMasterProtein" "Q9UJX2" "Cell division cycle protein 23 homolog OS=Homo sapiens OX=9606 GN=CDC23 PE=1 SV=3" "0.015" "False" "1.786" "2" "1" "1" "1" "597" "68.8" "7.02" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf04049" "8697" "ENSG00000094880" "CDC23" "A8K6E5; B4E3A2; B7WP05; D3DQB7; hsa:8697; O75433; Q53FN2; Q9BS73; Q9UJX2" "Cell cycle" "Separation of Sister Chromatids; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Inactivation of APC/C via direct inhibition of the APC/C complex; APC-Cdc20 mediated degradation of Nek2A; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5392183546824292188" "False" "Medium" "IsMasterProtein" "Q8NEY1" "Neuron navigator 1 OS=Homo sapiens OX=9606 GN=NAV1 PE=1 SV=2" "0.015" "False" "1.786" "0" "1" "1" "1" "1877" "202.3" "8.07" "2.34" "1" "cell organization and biogenesis;developmental processes" "cytoskeleton;other cell component" "other molecular function" "" "89796" "ENSG00000134369" "NAV1" "A8MS88; hsa:89796; Q5SVH1; Q5SVH2; Q5SVH3; Q5SVH7; Q5VUY9; Q8IVL2; Q8NEY1; Q96II1; Q9H7V9; Q9H9S9; Q9H9T5; Q9UGI1; Q9ULK7; Q9ULR9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2558457419742153856" "False" "Medium" "IsMasterProtein" "P53567" "CCAAT/enhancer-binding protein gamma OS=Homo sapiens OX=9606 GN=CEBPG PE=1 SV=1" "0.015" "False" "1.779" "5" "1" "1" "1" "150" "16.4" "9.77" "2.18" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07716" "1054" "ENSG00000153879" "CEBPG" "B2R946; hsa:1054; P53567; Q5U052" "Differentiation of white and brown adipocyte; Transcriptional cascade regulating adipogenesis" "Response of EIF2AK1 (HRI) to heme deficiency; ATF4 activates genes in response to endoplasmic reticulum stress; Response of EIF2AK4 (GCN2) to amino acid deficiency" "5" "0" "1.172" "1.172" "1.139" "1.028" "1.059" "1.023" "1.373" "1.151" "0.678" "120.0" "140.6" "140.6" "136.7" "123.4" "127.1" "122.8" "164.8" "138.2" "81.3" "" "" "" "" "" "" "" "" "" "" "63.5" "78.0" "80.5" "63.0" "66.7" "70.7" "72.3" "90.0" "77.5" "81.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3216762708121930784" "False" "Medium" "IsMasterProtein" "Q75N03" "E3 ubiquitin-protein ligase Hakai OS=Homo sapiens OX=9606 GN=CBLL1 PE=1 SV=1" "0.015" "False" "1.775" "2" "1" "1" "1" "491" "54.5" "8.29" "2.78" "1" "cell adhesion;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf18408" "79872" "ENSG00000105879" "CBLL1" "B7ZM03; Q75N03; Q8TAJ4; Q9H5S6" "" "InlA-mediated entry of Listeria monocytogenes into host cells" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5044889676122240904" "False" "Medium" "IsMasterProtein" "Q9H270" "Vacuolar protein sorting-associated protein 11 homolog OS=Homo sapiens OX=9606 GN=VPS11 PE=1 SV=1" "0.015" "False" "1.764" "1" "1" "1" "1" "941" "107.8" "7.05" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00637, Pf12451, Pf13923" "55823" "" "VPS11" "hsa:55823; Q8WY89; Q96EP8; Q9H270; Q9H6D9; Q9HCS6" "Network map of SARS-CoV-2 signaling pathway" "SARS-CoV-2 modulates autophagy" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5177067630619702561" "False" "Medium" "IsMasterProtein" "Q969S9" "Ribosome-releasing factor 2, mitochondrial OS=Homo sapiens OX=9606 GN=GFM2 PE=1 SV=1" "0.015" "False" "1.764" "1" "1" "1" "1" "779" "86.5" "6.51" "1.91" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" "84340" "ENSG00000164347" "GFM2" "A0AR28; hsa:84340; Q8N6D8; Q8WYI0; Q969S9; Q9H6Z1" "" "Mitochondrial translation termination" "1" "0" "1.302" "1.160" "1.271" "1.016" "0.928" "1.372" "1.091" "1.135" "3.148" "60.4" "78.6" "70.1" "76.8" "61.4" "56.0" "82.9" "65.9" "68.6" "190.2" "" "" "" "" "" "" "" "" "" "" "32.0" "43.6" "40.1" "35.4" "33.2" "31.2" "48.8" "36.0" "38.5" "190.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "602378726444352058" "False" "Medium" "IsMasterProtein" "O75828" "Carbonyl reductase [NADPH] 3 OS=Homo sapiens OX=9606 GN=CBR3 PE=1 SV=3" "0.015" "False" "1.762" "3" "1" "1" "1" "277" "30.8" "6.18" "1.79" "1" "other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00106" "874" "ENSG00000159231" "CBR3" "O75828; Q6FHP2" "Nuclear receptors meta-pathway; NRF2 pathway" "Phase I - Functionalization of compounds" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1736163179168070894" "False" "Medium" "IsMasterProtein" "Q9Y2V7" "Conserved oligomeric Golgi complex subunit 6 OS=Homo sapiens OX=9606 GN=COG6 PE=1 SV=2" "0.016" "False" "1.752" "2" "1" "1" "1" "657" "73.2" "5.76" "1.60" "1" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi" "" "Pf06419, Pf20653" "57511" "ENSG00000133103" "COG6" "hsa:57511; Q5T0U1; Q6AI19; Q86V49; Q9ULT5; Q9Y2V7" "" "COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "3" "0" "1.107" "0.896" "1.250" "0.855" "1.008" "1.243" "1.096" "0.893" "2.734" "61.3" "67.8" "54.9" "76.6" "52.4" "61.8" "76.2" "67.1" "54.7" "167.5" "" "" "" "" "" "" "" "" "" "" "32.4" "37.6" "31.4" "35.3" "28.3" "34.4" "44.8" "36.6" "30.7" "167.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2636434062481616227" "False" "Medium" "IsMasterProtein" "P42858" "Huntingtin OS=Homo sapiens OX=9606 GN=HTT PE=1 SV=2" "0.016" "False" "1.752" "0" "1" "1" "1" "3142" "347.4" "6.20" "2.71" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf20925, Pf20926, Pf20927" "3064" "ENSG00000197386" "HTT" "hsa:3064; P42858; Q9UQB7" "Mesodermal commitment pathway; Mesodermal commitment pathway; ERK pathway in Huntington's disease; Rett syndrome; 15q25 copy number variation; HDAC6 interactions in the central nervous system" "Regulation of MECP2 expression and activity" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "126204850056993689" "False" "Medium" "IsMasterProtein" "Q9NPB8" "Glycerophosphocholine phosphodiesterase GPCPD1 OS=Homo sapiens OX=9606 GN=GPCPD1 PE=1 SV=2" "0.016" "False" "1.751" "2" "1" "1" "1" "672" "76.0" "5.53" "0.00" "1" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00686, Pf03009" "56261" "ENSG00000125772" "GPCPD1" "D3DW06; hsa:56261; Q9BQL8; Q9NPB8; Q9NUX0" "" "Hydrolysis of LPC; Hydrolysis of LPE" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "729714306402912246" "False" "Medium" "IsMasterProtein" "Q15628" "Tumor necrosis factor receptor type 1-associated DEATH domain protein OS=Homo sapiens OX=9606 GN=TRADD PE=1 SV=2" "0.016" "False" "1.749" "3" "1" "1" "1" "312" "34.2" "6.27" "0.00" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00531, Pf09034" "8717" "ENSG00000102871" "TRADD" "B2RDS3; B3KQZ9; hsa:8717; Q15628; Q52NZ1" "TNF-alpha signaling pathway; Nanoparticle triggered regulated necrosis; Apoptosis; Ebstein-Barr virus LMP1 signaling; Novel intracellular components of RIG-I-like receptor pathway; p38 MAPK signaling pathway; Measles virus infection; Cytosolic DNA-sensing pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling; Defective RIPK1-mediated regulated necrosis" "20" "0" "0.918" "0.590" "0.887" "0.821" "0.825" "1.019" "0.812" "0.833" "1.196" "69.8" "64.1" "41.2" "61.9" "57.3" "57.6" "71.1" "56.7" "58.1" "83.5" "" "" "" "" "" "" "" "" "" "" "37.0" "35.5" "23.6" "28.5" "31.0" "32.0" "41.9" "30.9" "32.6" "83.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-699838257049576232" "False" "Medium" "IsMasterProtein" "Q8IWC1" "MAP7 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=MAP7D3 PE=1 SV=2" "0.017" "False" "1.744" "1" "1" "1" "1" "876" "98.4" "9.32" "0.00" "1" "cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf05672" "79649" "ENSG00000129680" "MAP7D3" "A2A2J0; A6NCZ7; A6NHR4; B4DWD2; H7BY77; hsa:79649; Q5JXI5; Q5JXI6; Q6P2S1; Q8IWC1; Q9H9M8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5424828533558395863" "False" "Medium" "IsMasterProtein" "O95352" "Ubiquitin-like modifier-activating enzyme ATG7 OS=Homo sapiens OX=9606 GN=ATG7 PE=1 SV=1" "0.017" "False" "1.741" "1" "1" "1" "1" "703" "77.9" "6.24" "1.64" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00899, Pf16420" "10533" "ENSG00000197548" "ATG7" "B4E170; E9PB95; hsa:10533; O95352; Q7L8L0; Q9BWP2; Q9UFH4" "Nanoparticle triggered autophagic cell death; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Clock-controlled autophagy in bone metabolism; Primary ovarian insufficiency; Autophagy in pancreatic ductal adenocarcinoma; ADHD and autism (ASD) linked metabolic pathways and SNP" "Neutrophil degranulation; Antigen processing: Ubiquitination & Proteasome degradation; Signaling by BRAF and RAF1 fusions; Macroautophagy" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4145241579063427930" "False" "Medium" "IsMasterProtein" "P68400" "Casein kinase II subunit alpha OS=Homo sapiens OX=9606 GN=CSNK2A1 PE=1 SV=1" "0.017" "False" "1.741" "2" "1" "1" "1" "391" "45.1" "7.74" "2.62" "1" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1457" "ENSG00000101266" "CSNK2A1" "B4DYS6; D3DVV8; hsa:1457; P19138; P20426; P68400; Q14013; Q5U065" "Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Pleural mesothelioma; Alzheimer's disease" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; Regulation of TP53 Activity through Phosphorylation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Maturation of hRSV A proteins; Receptor Mediated Mitophagy; Condensation of Prometaphase Chromosomes; Synthesis of PC" "22" "0" "1.018" "0.903" "0.923" "1.048" "0.963" "0.881" "0.821" "0.999" "1.758" "220.9" "224.9" "199.6" "203.8" "231.4" "212.6" "194.5" "181.4" "220.6" "388.4" "" "" "" "" "" "" "" "" "" "" "117.0" "124.7" "114.3" "93.9" "125.2" "118.3" "114.5" "99.0" "123.8" "388.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-847622519832317199" "False" "Medium" "IsMasterProtein" "O75626" "PR domain zinc finger protein 1 OS=Homo sapiens OX=9606 GN=PRDM1 PE=1 SV=2" "0.017" "False" "1.738" "1" "1" "1" "1" "825" "91.7" "8.48" "3.22" "1" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf21549" "639" "ENSG00000057657" "PRDM1" "B2REA6; E1P5E0; hsa:639; O75626; Q86WM7" "Nucleotide-binding oligomerization domain (NOD) pathway; Vitamin D receptor pathway; IL6 signaling pathway; Leukocyte-intrinsic Hippo pathway functions; Extrafollicular and follicular B cell activation by SARS-CoV-2; Primary ovarian insufficiency" "STAT3 nuclear events downstream of ALK signaling; Specification of primordial germ cells; Regulation of TP53 Expression" "9" "0" "1.012" "1.011" "0.984" "1.091" "1.053" "1.309" "1.350" "1.170" "1.281" "312.3" "315.9" "315.6" "307.4" "340.6" "328.9" "408.8" "421.7" "365.4" "400.0" "" "" "" "" "" "" "" "" "" "" "165.3" "175.1" "180.7" "141.6" "184.3" "183.0" "240.6" "230.2" "205.0" "400.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3531363712700192847" "False" "Medium" "IsMasterProtein" "Q9NZJ6" "Ubiquinone biosynthesis O-methyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=COQ3 PE=1 SV=3" "0.017" "False" "1.736" "2" "1" "1" "1" "369" "41.0" "7.42" "2.01" "1" "other metabolic processes;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf08241" "51805" "ENSG00000132423" "COQ3" "B3KPX0; hsa:51805; Q5T061; Q6P4F0; Q8IXG6; Q96BG1; Q9H0N1; Q9NZJ6" "" "Ubiquinol biosynthesis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5965687288212214297" "False" "Medium" "IsMasterProtein" "Q7L2H7" "Eukaryotic translation initiation factor 3 subunit M OS=Homo sapiens OX=9606 GN=EIF3M PE=1 SV=1" "0.017" "False" "1.734" "2" "1" "2" "1" "374" "42.5" "5.63" "4.42" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01399, Pf18005" "10480" "ENSG00000149100" "EIF3M" "A8K7X4; B4E2Q4; hsa:10480; O60735; Q2F836; Q53HL6; Q7L2H7; Q9BXW1" "" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "6" "0" "1.022" "1.131" "1.407" "1.497" "1.283" "1.071" "0.946" "1.068" "2.075" "41.7" "42.7" "47.2" "58.7" "62.5" "53.5" "44.7" "39.5" "44.6" "86.6" "" "" "" "" "" "" "" "" "" "" "22.1" "23.7" "27.0" "27.1" "33.8" "29.8" "26.3" "21.6" "25.0" "86.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9075280951894741873" "False" "Medium" "IsMasterProtein" "Q9NQP4" "Prefoldin subunit 4 OS=Homo sapiens OX=9606 GN=PFDN4 PE=1 SV=1" "0.017" "False" "1.729" "9" "1" "1" "1" "134" "15.3" "4.53" "1.87" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01920" "5203" "ENSG00000101132" "PFDN4" "hsa:5203; Q5TD11; Q92779; Q9NQP4" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8996103182095070186" "False" "Medium" "IsMasterProtein" "Q9UBF6" "RING-box protein 2 OS=Homo sapiens OX=9606 GN=RNF7 PE=1 SV=1" "0.017" "False" "1.727" "8" "1" "1" "1" "113" "12.7" "5.44" "0.00" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12678" "9616" "ENSG00000114125" "RNF7" "A8K1H9; A8MTB5; C9JYL3; D3DNF7; D3DNF8; hsa:9616; Q9BXN8; Q9UBF6; Q9Y5M7" "Apoptosis-related network due to altered Notch3 in ovarian cancer; Modulators of TCR signaling and T cell activation" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Inactivation of CSF3 (G-CSF) signaling" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4890653308716064100" "False" "Medium" "IsMasterProtein" "Q9H981" "Actin-related protein 8 OS=Homo sapiens OX=9606 GN=ACTR8 PE=1 SV=2" "0.017" "False" "1.727" "1" "1" "1" "1" "624" "70.4" "7.78" "2.30" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus" "other molecular function" "Pf00022" "93973" "ENSG00000113812" "ACTR8" "B3KSW7; hsa:93973; Q8N566; Q9H663; Q9H981" "" "UCH proteinases; DNA Damage Recognition in GG-NER" "2" "0" "1.211" "1.281" "1.229" "1.298" "1.190" "1.159" "1.064" "1.216" "1.640" "49.2" "59.5" "63.0" "60.4" "63.8" "58.5" "57.0" "52.3" "59.8" "80.6" "" "" "" "" "" "" "" "" "" "" "26.0" "33.0" "36.1" "27.8" "34.5" "32.5" "33.5" "28.6" "33.5" "80.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9164959202025983104" "False" "Medium" "IsMasterProtein" "Q9BSJ2" "Gamma-tubulin complex component 2 OS=Homo sapiens OX=9606 GN=TUBGCP2 PE=1 SV=2" "0.017" "False" "1.726" "1" "1" "1" "1" "902" "102.5" "6.84" "2.54" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity" "Pf04130, Pf17681" "10844" "ENSG00000130640" "TUBGCP2" "B4DM18; B7ZKL8; F5H4E0; F5H4L0; hsa:10844; O43632; Q5VWX7; Q9BSJ2" "Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "4" "0" "1.192" "1.041" "1.128" "1.059" "1.068" "1.048" "0.812" "1.032" "2.061" "123.4" "147.1" "128.4" "139.3" "130.7" "131.8" "129.3" "100.2" "127.4" "254.4" "" "" "" "" "" "" "" "" "" "" "65.3" "81.6" "73.6" "64.1" "70.7" "73.3" "76.1" "54.7" "71.5" "254.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8840476301148053294" "False" "Medium" "IsMasterProtein" "Q9NVI1" "Fanconi anemia group I protein OS=Homo sapiens OX=9606 GN=FANCI PE=1 SV=4" "0.017" "False" "1.723" "1" "1" "1" "1" "1328" "149.2" "6.74" "1.95" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf14674, Pf14675, Pf14676, Pf14677, Pf14678, Pf14679, Pf14680" "55215" "ENSG00000140525" "FANCI" "A4ZVE4; A5YMH4; A6NJZ0; hsa:55215; Q96JN1; Q96ST0; Q9BT96; Q9NVI1" "Gastric cancer network 2; DNA repair pathways, full network; 15q11q13 copy number variation" "Fanconi Anemia Pathway; TP53 Regulates Transcription of DNA Repair Genes" "5" "0" "1.221" "1.074" "1.271" "1.081" "0.887" "0.855" "0.615" "1.052" "3.905" "39.7" "48.5" "42.7" "50.5" "43.0" "35.2" "34.0" "24.4" "41.8" "155.2" "" "" "" "" "" "" "" "" "" "" "21.0" "26.9" "24.4" "23.3" "23.2" "19.6" "20.0" "13.3" "23.4" "155.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3735327687387277491" "False" "Medium" "IsMasterProtein" "Q16254" "Transcription factor E2F4 OS=Homo sapiens OX=9606 GN=E2F4 PE=1 SV=2" "0.017" "False" "1.719" "2" "1" "1" "1" "413" "43.9" "4.75" "1.81" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02319, Pf16421" "1874" "ENSG00000205250" "E2F4" "A6NGR8; B5BU56; hsa:1874; Q12991; Q15328; Q16254" "Cell cycle; Adipogenesis; TGF-beta signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; Alstrom syndrome" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Cyclin D associated events in G1; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; G1/S-Specific Transcription; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "14" "0" "1.122" "1.103" "1.242" "1.151" "1.311" "1.085" "0.994" "1.288" "2.113" "33.3" "37.4" "36.7" "41.4" "38.4" "43.7" "36.1" "33.1" "42.9" "70.4" "" "" "" "" "" "" "" "" "" "" "17.6" "20.7" "21.0" "19.0" "20.7" "24.3" "21.3" "18.1" "24.1" "70.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "34707929049350531" "False" "Medium" "IsMasterProtein" "P51151" "Ras-related protein Rab-9A OS=Homo sapiens OX=9606 GN=RAB9A PE=1 SV=1" "0.017" "False" "1.719" "3" "1" "1" "1" "201" "22.8" "5.47" "2.90" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "9367" "ENSG00000123595" "RAB9A" "A8K390; hsa:9367; P51151; Q6ICN1" "Ebola virus infection in host; Measles virus infection" "RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Retrograde transport at the Trans-Golgi-Network; RHOBTB3 ATPase cycle" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5516289566189376071" "False" "Medium" "IsMasterProtein" "Q13084" "Large ribosomal subunit protein bL28m OS=Homo sapiens OX=9606 GN=MRPL28 PE=1 SV=4" "0.017" "False" "1.718" "4" "1" "1" "1" "256" "30.1" "8.29" "1.67" "1" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "other molecular function" "Pf00830" "10573" "ENSG00000086504" "MRPL28" "B2RCM4; D3DU46; hsa:10573; Q13084; Q4TT39; Q96S26; Q9BQD8; Q9BR04" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.027" "1.039" "0.864" "1.024" "1.108" "0.917" "0.761" "0.869" "1.450" "51.6" "53.0" "53.6" "44.6" "52.8" "57.2" "47.3" "39.2" "44.8" "74.8" "" "" "" "" "" "" "" "" "" "" "27.3" "29.4" "30.7" "20.5" "28.6" "31.8" "27.8" "21.4" "25.1" "74.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2370626703481031957" "False" "Medium" "IsMasterProtein" "Q9H7N4" "Splicing factor, arginine/serine-rich 19 OS=Homo sapiens OX=9606 GN=SCAF1 PE=1 SV=3" "0.017" "False" "1.715" "1" "1" "1" "1" "1312" "139.2" "9.25" "1.84" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "58506" "ENSG00000126461" "SCAF1" "hsa:58506; Q7Z5V7; Q8WVA1; Q9H7N4; Q9NR59" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7407622379677965561" "False" "Medium" "IsMasterProtein" "Q5QGS0" "Neurite extension and migration factor OS=Homo sapiens OX=9606 GN=NEXMIF PE=1 SV=1" "0.017" "False" "1.715" "1" "1" "1" "1" "1516" "167.4" "6.40" "2.14" "1" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf15735" "340533" "ENSG00000050030" "NEXMIF" "A7YY87; hsa:340533; Q5JUX9; Q5QGS0; Q8IVE9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7557480247223307302" "False" "Medium" "IsMasterProtein" "O94806" "Serine/threonine-protein kinase D3 OS=Homo sapiens OX=9606 GN=PRKD3 PE=1 SV=1" "0.017" "False" "1.707" "1" "1" "1" "1" "890" "100.4" "6.87" "0.00" "1" "protein metabolism;other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol;nucleus" "kinase activity;other molecular function" "Pf00069, Pf00130, Pf00169" "23683" "ENSG00000115825" "PRKD3" "D6W587; hsa:23683; O94806; Q53TR7; Q8NEL8" "G protein signaling pathways; Hippo signaling regulation pathways; Chronic hyperglycemia impairment of neuron function" "Sphingolipid de novo biosynthesis" "4" "0" "1.284" "1.373" "1.353" "1.280" "1.169" "1.375" "0.959" "1.247" "1.244" "32.9" "42.2" "45.2" "44.5" "42.1" "38.5" "45.3" "31.6" "41.0" "40.9" "" "" "" "" "" "" "" "" "" "" "17.4" "23.4" "25.9" "20.5" "22.8" "21.4" "26.6" "17.2" "23.0" "40.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5897019344324903703" "False" "Medium" "IsMasterProtein" "Q9NP79" "Vacuolar protein sorting-associated protein VTA1 homolog OS=Homo sapiens OX=9606 GN=VTA1 PE=1 SV=1" "0.017" "False" "1.706" "2" "1" "1" "1" "307" "33.9" "6.29" "2.54" "1" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf04652, Pf18097" "51534" "ENSG00000009844" "VTA1" "B4DW55; E1P594; E7ETQ7; hsa:51534; Q5TGM1; Q6IAE8; Q9H0R2; Q9H3K9; Q9NP79; Q9P0Q0" "" "Endosomal Sorting Complex Required For Transport (ESCRT); Budding and maturation of HIV virion" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3408450596310404748" "False" "Medium" "IsMasterProtein" "Q9UHA4" "Ragulator complex protein LAMTOR3 OS=Homo sapiens OX=9606 GN=LAMTOR3 PE=1 SV=1" "0.017" "False" "1.701" "6" "1" "1" "1" "124" "13.6" "7.34" "2.78" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf08923" "8649" "ENSG00000109270" "LAMTOR3" "B2R4A1; hsa:8649; J3KMX4; Q9H364; Q9UHA4" "MAPK signaling pathway; MAPK cascade; Gastrin signaling pathway; Melanoma" "Neutrophil degranulation; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; MAP2K and MAPK activation; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "13" "0" "1.021" "1.005" "0.999" "1.115" "1.052" "1.158" "1.106" "1.074" "0.497" "313.1" "319.8" "314.6" "312.6" "349.0" "329.3" "362.6" "346.4" "336.1" "155.6" "" "" "" "" "" "" "" "" "" "" "165.8" "177.3" "180.2" "144.0" "188.8" "183.2" "213.4" "189.1" "188.5" "155.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3241887692250600056" "False" "Medium" "IsMasterProtein" "Q15149" "Plectin OS=Homo sapiens OX=9606 GN=PLEC PE=1 SV=3" "0.018" "False" "1.699" "0" "1" "1" "1" "4684" "531.5" "5.96" "1.82" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00681, Pf03501, Pf17902, Pf18373, Pf21019, Pf21020, Pf21097" "5339" "ENSG00000178209" "PLEC" "hsa:5339; Q15148; Q15149; Q16640; Q6S376; Q6S377; Q6S378; Q6S379; Q6S380; Q6S381; Q6S382; Q6S383" "Envelope proteins and their potential roles in EDMD physiopathology" "Assembly of collagen fibrils and other multimeric structures; Caspase-mediated cleavage of cytoskeletal proteins; Type I hemidesmosome assembly" "4" "0" "1.033" "0.921" "2.041" "0.902" "1.108" "1.452" "1.330" "1.019" "0.940" "36.3" "37.5" "33.4" "74.1" "32.7" "40.2" "52.7" "48.2" "37.0" "34.1" "" "" "" "" "" "" "" "" "" "" "19.2" "20.8" "19.1" "34.1" "17.7" "22.4" "31.0" "26.3" "20.7" "34.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6075912895449175249" "False" "Medium" "IsMasterProtein" "Q9NTG7" "NAD-dependent protein deacetylase sirtuin-3, mitochondrial OS=Homo sapiens OX=9606 GN=SIRT3 PE=1 SV=2" "0.018" "False" "1.694" "3" "1" "1" "1" "399" "43.5" "8.70" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02146" "23410" "ENSG00000142082" "SIRT3" "B7Z5U6; hsa:23410; Q9NTG7; Q9Y6E8" "Energy metabolism; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence" "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Transcriptional activation of mitochondrial biogenesis; Regulation of FOXO transcriptional activity by acetylation" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5196394549713774835" "False" "Medium" "IsMasterProtein" "Q69YU5" "Ubiquinol-cytochrome c reductase complex assembly factor 6 OS=Homo sapiens OX=9606 GN=UQCC6 PE=1 SV=2" "0.018" "False" "1.693" "10" "1" "1" "1" "71" "8.0" "9.16" "1.78" "1" "cell organization and biogenesis" "other membranes;mitochondrion" "" "Pf14990" "728568" "ENSG00000204954" "UQCC6" "hsa:728568; Q69YU5" "" "" "0" "0" "1.078" "1.045" "1.041" "1.220" "0.894" "0.989" "0.859" "0.940" "0.510" "97.9" "105.6" "102.4" "102.0" "119.5" "87.6" "96.8" "84.1" "92.0" "49.9" "" "" "" "" "" "" "" "" "" "" "51.9" "58.6" "58.6" "47.0" "64.6" "48.7" "57.0" "45.9" "51.6" "49.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1730131359197889533" "False" "Medium" "IsMasterProtein" "Q8IVU3" "Probable E3 ubiquitin-protein ligase HERC6 OS=Homo sapiens OX=9606 GN=HERC6 PE=1 SV=2" "0.018" "False" "1.693" "1" "1" "1" "1" "1022" "115.1" "7.96" "2.30" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00415, Pf00632, Pf13540" "55008" "ENSG00000138642" "HERC6" "B4DIY5; hsa:55008; Q5GC90; Q5GRH3; Q5HYM6; Q5JPB6; Q6PIF4; Q8IVU3; Q8NAN3; Q9NWS4" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.932" "0.902" "0.891" "0.913" "0.918" "0.879" "0.880" "0.855" "0.483" "289.6" "269.8" "261.3" "258.1" "264.3" "266.0" "254.5" "254.7" "247.7" "139.9" "" "" "" "" "" "" "" "" "" "" "153.3" "149.6" "149.6" "118.8" "143.0" "148.0" "149.8" "139.0" "138.9" "139.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2210481861453836415" "False" "Medium" "IsMasterProtein" "Q9BVM2" "Protein DPCD OS=Homo sapiens OX=9606 GN=DPCD PE=1 SV=2" "0.018" "False" "1.688" "4" "1" "1" "1" "203" "23.2" "9.03" "2.10" "1" "transport;developmental processes;other biological processes" "non-structural extracellular" "" "Pf14913" "25911" "ENSG00000166171" "DPCD" "A8K289; hsa:25911; Q6QNL3; Q8N5R1; Q9BVM2; Q9UFY6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4147334840207979337" "False" "Medium" "IsMasterProtein" "Q8WUN7" "Ubiquitin domain-containing protein 2 OS=Homo sapiens OX=9606 GN=UBTD2 PE=1 SV=2" "0.018" "False" "1.685" "5" "1" "1" "1" "234" "26.2" "5.67" "0.00" "1" "" "other cell component" "" "Pf00240, Pf16455" "92181" "ENSG00000168246" "UBTD2" "hsa:92181; Q8TDQ3; Q8WUN7" "" "" "0" "0" "0.925" "0.706" "0.848" "1.252" "0.770" "0.928" "1.171" "1.086" "0.580" "29.8" "27.6" "21.1" "25.3" "37.4" "23.0" "27.7" "34.9" "32.4" "17.3" "" "" "" "" "" "" "" "" "" "" "15.8" "15.3" "12.1" "11.7" "20.2" "12.8" "16.3" "19.1" "18.2" "17.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8069107240958525203" "False" "Medium" "IsMasterProtein" "Q92993" "Histone acetyltransferase KAT5 OS=Homo sapiens OX=9606 GN=KAT5 PE=1 SV=2" "0.018" "False" "1.681" "2" "1" "1" "1" "513" "58.5" "8.48" "2.50" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01853, Pf11717, Pf17772" "10524" "ENSG00000172977" "KAT5" "B4E3C7; C9JL99; hsa:10524; O95624; Q13430; Q17RW5; Q561W3; Q6GSE8; Q92993; Q9BWK7" "Androgen receptor signaling pathway; ATM signaling in development and disease ; Joubert syndrome; Gastrin signaling pathway; HDAC6 interactions in the central nervous system" "Estrogen-dependent gene expression; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; DNA Damage/Telomere Stress Induced Senescence; HATs acetylate histones; Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Formation of the beta-catenin:TCF transactivating complex; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Cardiogenesis; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Nonhomologous End-Joining (NHEJ); Sensing of DNA Double Strand Breaks" "27" "0" "1.028" "0.936" "1.323" "1.124" "1.171" "2.130" "1.806" "1.975" "2.667" "84.5" "86.9" "79.1" "111.7" "94.9" "98.9" "179.9" "152.6" "166.9" "225.3" "" "" "" "" "" "" "" "" "" "" "44.7" "48.2" "45.3" "51.5" "51.4" "55.0" "105.9" "83.3" "93.6" "225.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2783720911668015522" "False" "Medium" "IsMasterProtein" "Q9NWT6" "Hypoxia-inducible factor 1-alpha inhibitor OS=Homo sapiens OX=9606 GN=HIF1AN PE=1 SV=2" "0.018" "False" "1.680" "2" "1" "1" "1" "349" "40.3" "5.57" "2.68" "1" "other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf13621" "55662" "ENSG00000166135" "HIF1AN" "D3DR69; hsa:55662; Q5W147; Q969Q7; Q9NPV5; Q9NWT6" "MicroRNA for targeting cancer growth and vascularization in glioblastoma; Photodynamic therapy-induced HIF-1 survival signaling" "Cellular response to hypoxia" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1906785433789607245" "False" "Medium" "IsMasterProtein" "Q4G0X9" "Coiled-coil domain-containing protein 40 OS=Homo sapiens OX=9606 GN=CCDC40 PE=1 SV=2" "0.018" "False" "1.679" "1" "1" "1" "1" "1142" "130.0" "5.29" "0.00" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;cytoskeleton;other cell component" "" "Pf08647" "55036" "ENSG00000141519; ENSG00000291505" "CCDC40" "A8MTD2; C9JTI9; C9JTJ0; C9JXW1; hsa:55036; J3QSY2; Q4G0X9; Q6PE47; Q9HCD2; Q9NWL5" "Ciliary landscape; Ciliopathies" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8382975367682905247" "False" "Medium" "IsMasterProtein" "Q8N819" "Probable protein phosphatase 1N OS=Homo sapiens OX=9606 GN=PPM1N PE=2 SV=2" "0.018" "False" "1.679" "2" "1" "2" "1" "430" "46.1" "6.62" "4.40" "1" "other biological processes" "cytosol;nucleus" "other molecular function" "Pf00481, Pf07830" "147699" "ENSG00000213889" "PPM1N" "hsa:147699; Q6P662; Q8N819" "" "" "0" "0" "0.933" "0.959" "1.065" "1.078" "0.989" "1.091" "1.034" "1.043" "1.178" "254.5" "237.4" "244.0" "271.0" "274.3" "251.7" "277.7" "263.1" "265.4" "299.7" "" "" "" "" "" "" "" "" "" "" "134.7" "131.6" "139.8" "124.8" "148.4" "140.0" "163.4" "143.6" "148.9" "299.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4718065310323386899" "False" "Medium" "IsMasterProtein" "Q5VSL9" "Striatin-interacting protein 1 OS=Homo sapiens OX=9606 GN=STRIP1 PE=1 SV=1" "0.018" "False" "1.675" "1" "1" "1" "1" "837" "95.5" "6.29" "0.00" "1" "cell organization and biogenesis;other biological processes" "cytosol;nucleus" "other molecular function" "Pf07923, Pf11882" "85369" "ENSG00000143093" "STRIP1" "hsa:85369; Q0V925; Q5VSL8; Q5VSL9; Q658K2; Q6ZV31; Q8N598; Q96SN2; Q9C0A2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2969987479368307007" "False" "Medium" "IsMasterProtein" "O14657" "Torsin-1B OS=Homo sapiens OX=9606 GN=TOR1B PE=1 SV=2" "0.018" "False" "1.674" "3" "1" "1" "1" "336" "38.0" "8.54" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;ER/Golgi;nucleus" "cytoskeletal activity;other molecular function" "Pf06309, Pf21376" "27348" "ENSG00000136816" "TOR1B" "hsa:27348; O14657" "" "Cargo recognition for clathrin-mediated endocytosis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4123953138095996018" "False" "Medium" "IsMasterProtein" "O95398" "Rap guanine nucleotide exchange factor 3 OS=Homo sapiens OX=9606 GN=RAPGEF3 PE=1 SV=6" "0.018" "False" "1.673" "1" "1" "1" "1" "923" "103.7" "7.56" "0.00" "1" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf00610, Pf00617, Pf00618" "10411" "ENSG00000079337" "RAPGEF3" "A8K2G5; E7EQC8; hsa:10411; O95398; O95634; Q8WVN0" "Corticotropin-releasing hormone signaling pathway; EPAC1 and PKA reduction of retinal inflammation" "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Integrin signaling; Rap1 signalling" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3394640427609964495" "False" "Medium" "IsMasterProtein" "Q86VP3" "Phosphofurin acidic cluster sorting protein 2 OS=Homo sapiens OX=9606 GN=PACS2 PE=1 SV=3" "0.018" "False" "1.666" "1" "1" "1" "1" "889" "97.6" "6.60" "0.00" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "mitochondrion;ER/Golgi" "other molecular function" "Pf10254" "23241" "ENSG00000179364" "PACS2" "A2VDJ9; G8JLK3; hsa:23241; O60342; Q6P191; Q86VP3; Q96FL7" "" "" "0" "0" "1.213" "1.075" "1.291" "1.082" "0.972" "0.982" "0.904" "1.120" "1.284" "149.1" "180.8" "160.3" "192.5" "161.4" "144.9" "146.4" "134.8" "167.0" "191.4" "" "" "" "" "" "" "" "" "" "" "79.0" "100.2" "91.8" "88.6" "87.3" "80.6" "86.1" "73.6" "93.7" "191.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7945437556686127836" "False" "Medium" "IsMasterProtein" "Q96GA3" "Protein LTV1 homolog OS=Homo sapiens OX=9606 GN=LTV1 PE=1 SV=1" "0.018" "False" "1.665" "1" "1" "1" "1" "475" "54.8" "4.91" "1.98" "1" "transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04180" "84946" "ENSG00000135521" "LTV1" "hsa:84946; Q96GA3; Q96JX8" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.086" "0.814" "1.298" "1.149" "0.888" "1.418" "1.427" "1.400" "1.189" "63.3" "68.7" "51.5" "82.1" "72.7" "56.2" "89.7" "90.3" "88.6" "75.2" "" "" "" "" "" "" "" "" "" "" "33.5" "38.1" "29.5" "37.8" "39.3" "31.2" "52.8" "49.3" "49.7" "75.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1707111681236337832" "False" "Medium" "IsMasterProtein" "Q96BY7" "Autophagy-related protein 2 homolog B OS=Homo sapiens OX=9606 GN=ATG2B PE=1 SV=5" "0.018" "False" "1.665" "0" "1" "1" "1" "2078" "232.6" "5.76" "2.35" "1" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf09333, Pf12624, Pf13329" "55102" "ENSG00000066739" "ATG2B" "hsa:55102; Q6ZRE7; Q96BY7; Q96DQ3; Q9NW80" "Alzheimer's disease and miRNA effects; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Alzheimer's disease" "" "3" "0" "1.282" "1.028" "1.266" "1.226" "1.715" "1.063" "0.942" "1.047" "1.408" "89.1" "114.2" "91.6" "112.8" "109.3" "152.8" "94.7" "83.9" "93.3" "125.4" "" "" "" "" "" "" "" "" "" "" "47.2" "63.3" "52.5" "51.9" "59.1" "85.0" "55.7" "45.8" "52.3" "125.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1258287404599916769" "False" "Medium" "IsMasterProtein" "P43251" "Biotinidase OS=Homo sapiens OX=9606 GN=BTD PE=1 SV=2" "0.018" "False" "1.664" "2" "1" "2" "1" "543" "61.1" "6.25" "0.00" "1" "other metabolic processes;developmental processes" "non-structural extracellular;mitochondrion" "other molecular function" "Pf00795, Pf19018" "686" "ENSG00000169814" "BTD" "A6NHF2; B2R865; B4DFX1; B4DLJ9; B7Z7C9; F8W1Q3; hsa:686; P43251; Q96EM9" "" "Biotin transport and metabolism; Defective BTD causes biotidinase deficiency" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3069222213546241836" "False" "Medium" "IsMasterProtein" "A0A0A0MS04" "Probable non-functional T cell receptor beta variable 6-7 OS=Homo sapiens OX=9606 GN=TRBV6-7 PE=1 SV=6" "0.018" "False" "1.661" "11" "1" "1" "1" "114" "12.6" "7.78" "2.71" "1" "signal transduction;other biological processes" "plasma membrane;other membranes" "" "Pf07686" "" "ENSG00000253188; ENSG00000282470" "TRBV6-7" "A0A0A0MS04" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5883384996074355678" "False" "Medium" "IsMasterProtein" "Q8TD08" "Mitogen-activated protein kinase 15 OS=Homo sapiens OX=9606 GN=MAPK15 PE=1 SV=1" "0.018" "False" "1.660" "2" "1" "1" "1" "544" "59.8" "8.97" "2.44" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069" "225689" "ENSG00000181085; ENSG00000274205" "MAPK15" "hsa:225689; Q2TCF9; Q8N362; Q8TD08" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8316251485158664462" "False" "Medium" "IsMasterProtein" "Q8N8A6" "ATP-dependent RNA helicase DDX51 OS=Homo sapiens OX=9606 GN=DDX51 PE=1 SV=3" "0.018" "False" "1.660" "1" "1" "1" "1" "666" "72.4" "8.16" "1.95" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271" "317781" "ENSG00000185163; ENSG00000288503" "DDX51" "A8MPT9; hsa:317781; Q5CZ71; Q8IXK5; Q8N8A6; Q96ED1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3531951912742516330" "False" "Medium" "IsMasterProtein" "Q14643" "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 OS=Homo sapiens OX=9606 GN=ITPR1 PE=1 SV=3" "0.018" "False" "1.658" "1" "1" "3" "1" "2758" "313.7" "6.04" "0.00" "1" "cell-cell signaling;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00520, Pf01365, Pf02815, Pf08454, Pf08709" "3708" "ENSG00000150995" "ITPR1" "E7EPX7; E9PDE9; hsa:3708; Q14643; Q14660; Q99897" "Alzheimer's disease and miRNA effects; Myometrial relaxation and contraction pathways; G protein signaling pathways; Cell-type dependent selectivity of CCK2R signaling; Resistin as a regulator of inflammation; Fragile X syndrome; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Vitamin D-sensitive calcium signaling in depression; PKC-gamma calcium signaling pathway in ataxia; Type I collagen synthesis in the context of osteogenesis imperfecta; GPR143 in melanocytes and retinal pigment epithelium cells; STING pathway in Kawasaki-like disease and COVID-19; Alzheimer's disease; GDNF signaling; Calcium regulation in cardiac cells; KCNQ2-related epilepsies; 15q25 copy number variation; T-cell receptor signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling" "Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; cGMP effects; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Ca2+ pathway; VEGFR2 mediated cell proliferation; Elevation of cytosolic Ca2+ levels; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation; Effects of PIP2 hydrolysis" "35" "0" "1.096" "1.160" "1.358" "1.022" "0.984" "1.451" "1.498" "1.180" "0.599" "35.3" "38.7" "41.0" "48.0" "36.1" "34.8" "51.2" "52.9" "41.7" "21.2" "" "" "" "" "" "" "" "" "" "" "18.7" "21.5" "23.5" "22.1" "19.5" "19.3" "30.2" "28.9" "23.4" "21.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5690407567518484702" "False" "Medium" "IsMasterProtein" "Q9HCS7" "Pre-mRNA-splicing factor SYF1 OS=Homo sapiens OX=9606 GN=XAB2 PE=1 SV=2" "0.018" "False" "1.656" "1" "1" "1" "1" "855" "99.9" "6.23" "0.00" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes" "nucleus;other cell component" "" "Pf13181" "56949" "ENSG00000076924" "XAB2" "hsa:56949; Q8TET6; Q96HB0; Q96IW0; Q9HCS7; Q9NRG6; Q9ULP3" "Rett syndrome; Nucleotide excision repair in xeroderma pigmentosum" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5845419377566949929" "False" "Medium" "IsMasterProtein" "P61077" "Ubiquitin-conjugating enzyme E2 D3 OS=Homo sapiens OX=9606 GN=UBE2D3 PE=1 SV=1" "0.018" "False" "1.653" "5" "1" "2" "1" "147" "16.7" "7.80" "4.74" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00179" "7323" "ENSG00000109332" "UBE2D3" "A6NJ93; A6NJB1; A6NM99; P47986; P61077; Q6IB88; Q6NXS4; Q8N924" "Proteasome degradation" "Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation; E3 ubiquitin ligases ubiquitinate target proteins; Peroxisomal protein import; IKK complex recruitment mediated by RIP1; Signaling by BMP; Inactivation of CSF3 (G-CSF) signaling; TICAM1, RIP1-mediated IKK complex recruitment; Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity" "13" "0" "1.154" "1.095" "1.092" "1.106" "1.160" "1.174" "0.844" "1.122" "3.995" "237.2" "273.6" "259.6" "258.9" "262.4" "275.2" "278.4" "200.1" "266.2" "947.5" "" "" "" "" "" "" "" "" "" "" "125.6" "151.7" "148.7" "119.2" "142.0" "153.1" "163.8" "109.2" "149.3" "947.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2492385812914646204" "False" "Medium" "IsMasterProtein" "O14730" "Serine/threonine-protein kinase RIO3 OS=Homo sapiens OX=9606 GN=RIOK3 PE=1 SV=2" "0.018" "False" "1.653" "2" "1" "1" "1" "519" "59.1" "5.76" "0.00" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf01163" "8780" "ENSG00000101782" "RIOK3" "O14730; Q8IXN9" "Hematopoietic stem cell differentiation" "Major pathway of rRNA processing in the nucleolus and cytosol" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5828511565450602241" "False" "Medium" "IsMasterProtein" "P46939" "Utrophin OS=Homo sapiens OX=9606 GN=UTRN PE=1 SV=2" "0.018" "False" "1.641" "0" "1" "1" "1" "3433" "394.2" "5.33" "0.00" "1" "cell-cell signaling;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf00569, Pf09068, Pf09069" "7402" "ENSG00000152818" "UTRN" "hsa:7402; P46939; Q5SYY1; Q5SZ57; Q9UJ40" "Primary focal segmental glomerulosclerosis (FSGS)" "EGR2 and SOX10-mediated initiation of Schwann cell myelination" "2" "0" "1.090" "1.057" "1.191" "0.928" "1.293" "1.921" "1.779" "1.742" "1.699" "23.7" "25.8" "25.0" "28.2" "22.0" "30.6" "45.5" "42.1" "41.3" "40.2" "" "" "" "" "" "" "" "" "" "" "12.5" "14.3" "14.3" "13.0" "11.9" "17.0" "26.8" "23.0" "23.1" "40.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1960007696213453996" "False" "Medium" "IsMasterProtein" "Q8NE01" "Metal transporter CNNM3 OS=Homo sapiens OX=9606 GN=CNNM3 PE=1 SV=1" "0.019" "False" "1.638" "1" "1" "1" "1" "707" "76.1" "6.09" "2.12" "1" "transport;other biological processes" "plasma membrane;other membranes" "transporter activity" "Pf00571" "26505" "ENSG00000168763" "CNNM3" "B3KX67; hsa:26505; Q8NE01; Q8TBV4; Q96IW4; Q9NRK4; Q9NXW6" "2q11.2 copy number variation syndrome" "" "1" "0" "1.567" "1.203" "1.693" "1.337" "0.967" "1.409" "0.999" "1.085" "0.866" "80.1" "125.5" "96.4" "135.5" "107.1" "77.4" "112.8" "80.0" "86.9" "69.3" "" "" "" "" "" "" "" "" "" "" "42.4" "69.6" "55.2" "62.4" "57.9" "43.1" "66.4" "43.7" "48.8" "69.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8605151959694531472" "False" "Medium" "IsMasterProtein" "Q13888" "General transcription factor IIH subunit 2 OS=Homo sapiens OX=9606 GN=GTF2H2 PE=1 SV=1" "0.019" "False" "1.637" "2" "1" "1" "1" "395" "44.4" "6.76" "1.93" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "nucleus" "other molecular function" "Pf04056, Pf07975" "2966" "ENSG00000145736; ENSG00000275045; ENSG00000276910" "GTF2H2" "hsa:2966; Q13888; Q15570; Q15571; Q9BS41" "Eukaryotic transcription initiation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Dual Incision in GG-NER; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Formation of Incision Complex in GG-NER" "33" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7386528410140377558" "False" "Medium" "IsMasterProtein" "Q9H147" "Deoxynucleotidyltransferase terminal-interacting protein 1 OS=Homo sapiens OX=9606 GN=DNTTIP1 PE=1 SV=2" "0.019" "False" "1.637" "3" "1" "1" "1" "329" "37.0" "8.97" "0.00" "1" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf18192, Pf21229" "116092" "ENSG00000101457" "DNTTIP1" "B2RA18; hsa:116092; Q96DE3; Q9BQP2; Q9H147; Q9H148" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3782870004774892945" "False" "Medium" "IsMasterProtein" "Q15796" "Mothers against decapentaplegic homolog 2 OS=Homo sapiens OX=9606 GN=SMAD2 PE=1 SV=1" "0.019" "False" "1.637" "3" "1" "1" "1" "467" "52.3" "6.58" "0.00" "1" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf03165, Pf03166" "4087" "ENSG00000175387" "SMAD2" "hsa:4087; Q15796" "Cell cycle; AGE/RAGE pathway; Endoderm differentiation; Mesodermal commitment pathway; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; Tgif disruption of Shh signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Canonical and non-canonical TGF-B signaling; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Neovascularization processes; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Hepatitis B infection; TGF-beta receptor signaling in skeletal dysplasias; Regucalcin in proximal tubule epithelial kidney cells; Overlap between signal transduction pathways contributing to LMNA laminopathies; LDLRAD4 and what we know about it; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Progeria-associated lipodystrophy; Th17 cell differentiation pathway; GDNF signaling; Inflammatory bowel disease signaling; Macrophage-stimulating protein (MSP) signaling network map; HDAC6 interactions in the central nervous system; TGF-beta receptor signaling" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Ub-specific processing proteases; Formation of axial mesoderm; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Signaling by NODAL; FOXO-mediated transcription of cell cycle genes; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Germ layer formation at gastrulation; Formation of definitive endoderm; Transcriptional regulation of pluripotent stem cells; Signaling by Activin; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; SMAD4 MH2 Domain Mutants in Cancer; SMAD2/3 MH2 Domain Mutants in Cancer" "49" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1100964520603987926" "False" "Medium" "IsMasterProtein" "Q13825" "Methylglutaconyl-CoA hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=AUH PE=1 SV=1" "0.019" "False" "1.637" "2" "1" "1" "1" "339" "35.6" "9.48" "2.17" "1" "other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00378" "549" "ENSG00000148090" "AUH" "B1ALV7; B1ALV8; hsa:549; Q13825; Q8WUE4" "Amino acid metabolism" "Branched-chain amino acid catabolism" "2" "0" "1.246" "1.088" "1.076" "1.052" "1.137" "1.122" "1.143" "1.023" "0.843" "71.2" "88.7" "77.5" "76.7" "75.0" "81.0" "79.9" "81.4" "72.9" "60.1" "" "" "" "" "" "" "" "" "" "" "37.7" "49.2" "44.4" "35.3" "40.6" "45.1" "47.0" "44.4" "40.9" "60.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6990414283188081585" "False" "Medium" "IsMasterProtein" "O43660" "Pleiotropic regulator 1 OS=Homo sapiens OX=9606 GN=PLRG1 PE=1 SV=1" "0.019" "False" "1.635" "1" "1" "1" "1" "514" "57.2" "9.17" "2.45" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "" "Pf00400" "5356" "ENSG00000171566" "PLRG1" "B3KMK4; hsa:5356; O43660; Q3KQY5; Q8WUD8" "" "mRNA Splicing - Major Pathway" "1" "0" "0.949" "0.864" "0.901" "0.965" "0.951" "1.360" "1.200" "1.133" "0.862" "252.8" "239.8" "218.4" "227.9" "243.8" "240.3" "343.7" "303.2" "286.4" "217.8" "" "" "" "" "" "" "" "" "" "" "133.8" "133.0" "125.1" "104.9" "131.9" "133.7" "202.3" "165.5" "160.7" "217.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5225742282828706661" "False" "Medium" "IsMasterProtein" "Q8NDH2" "Leucine-rich repeat transmembrane protein CCDC168 OS=Homo sapiens OX=9606 GN=CCDC168 PE=1 SV=3" "0.019" "False" "1.633" "0" "1" "1" "1" "7081" "801.4" "8.79" "0.00" "1" "" "other membranes" "" "Pf15804" "643677" "ENSG00000175820" "CCDC168" "hsa:643677; Q8N800; Q8NDH2" "" "" "0" "0" "0.923" "1.235" "1.195" "0.972" "0.922" "1.104" "1.142" "1.004" "0.688" "126.2" "116.6" "155.9" "150.9" "122.8" "116.4" "139.3" "144.1" "126.7" "86.8" "" "" "" "" "" "" "" "" "" "" "66.8" "64.6" "89.3" "69.5" "66.4" "64.7" "82.0" "78.7" "71.1" "86.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6622895814543661851" "False" "Medium" "IsMasterProtein" "O15504" "Nucleoporin NUP42 OS=Homo sapiens OX=9606 GN=NUP42 PE=1 SV=1" "0.019" "False" "1.633" "2" "1" "1" "1" "423" "44.8" "9.19" "1.93" "1" "transport" "other membranes;cytosol;nucleus" "other molecular function" "Pf18044" "11097" "ENSG00000136243" "NUP42" "A4D143; B4DP42; hsa:11097; O15504; Q49AE7; Q9BS49" "" "HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "28" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3344145202623347770" "False" "Medium" "IsMasterProtein" "O60637" "Tetraspanin-3 OS=Homo sapiens OX=9606 GN=TSPAN3 PE=1 SV=1" "0.019" "False" "1.625" "3" "1" "1" "1" "253" "28.0" "5.81" "2.58" "1" "" "other membranes" "" "Pf00335" "10099" "ENSG00000140391" "TSPAN3" "A6NEH4; B3KQQ2; B4DP19; hsa:10099; O60637; Q9BW22; Q9NVX9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1355905293603533123" "False" "Medium" "IsMasterProtein" "Q9Y2Z2" "Protein MTO1 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=MTO1 PE=1 SV=2" "0.019" "False" "1.619" "1" "1" "1" "1" "717" "79.9" "8.31" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf01134, Pf13932, Pf21680" "25821" "ENSG00000135297" "MTO1" "B3KQB5; hsa:25821; Q5SWL2; Q5SWL3; Q5SWL4; Q8NDN7; Q8WZ57; Q96FE6; Q9BS06; Q9Y2Z2" "" "tRNA modification in the mitochondrion" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7331601319371966852" "False" "Medium" "IsMasterProtein" "P21964" "Catechol O-methyltransferase OS=Homo sapiens OX=9606 GN=COMT PE=1 SV=2" "0.019" "False" "1.615" "3" "1" "1" "1" "271" "30.0" "5.47" "2.32" "1" "cell-cell signaling;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01596" "1312" "ENSG00000093010" "COMT" "A8MPV9; hsa:1312; P21964; Q6IB07; Q6ICE6; Q9BWC7" "Dopamine metabolism; Flavan-3-ol metabolic pathway; MTHFR deficiency; 22q11.2 copy number variation syndrome; Primary ovarian insufficiency; Biogenic amine synthesis; Estrogen metabolism; Metapathway biotransformation Phase I and II; Methylation pathways" "Potential therapeutics for SARS; Methylation; Enzymatic degradation of dopamine by COMT; Enzymatic degradation of Dopamine by monoamine oxidase" "13" "0" "0.989" "1.034" "1.068" "2.374" "0.998" "1.574" "1.027" "1.024" "0.866" "152.7" "151.0" "157.9" "163.1" "362.6" "152.4" "240.4" "156.9" "156.4" "132.2" "" "" "" "" "" "" "" "" "" "" "80.9" "83.7" "90.4" "75.1" "196.2" "84.8" "141.5" "85.6" "87.7" "132.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "551510042259004717" "False" "Medium" "IsMasterProtein" "Q70J99" "Protein unc-13 homolog D OS=Homo sapiens OX=9606 GN=UNC13D PE=1 SV=1" "0.019" "False" "1.615" "1" "1" "1" "1" "1090" "123.2" "6.65" "0.00" "1" "stress response;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf06292" "201294" "ENSG00000092929" "UNC13D" "B4DWG9; hsa:201294; Q70J99; Q9H7K5" "Deregulation of Rab and Rab effector genes in bladder cancer" "Neutrophil degranulation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "559389685781558546" "False" "Medium" "IsMasterProtein" "Q8N9R8" "Protein SCAI OS=Homo sapiens OX=9606 GN=SCAI PE=1 SV=2" "0.019" "False" "1.615" "2" "1" "1" "1" "606" "70.4" "8.60" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf12070" "286205" "ENSG00000173611" "SCAI" "hsa:286205; Q3SXZ1; Q3SXZ2; Q5T163; Q8N1I4; Q8N9R8" "" "RHO GTPases Activate Formins" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8652321965736247269" "False" "Medium" "IsMasterProtein" "Q8TCA0" "Leucine-rich repeat-containing protein 20 OS=Homo sapiens OX=9606 GN=LRRC20 PE=1 SV=1" "0.019" "False" "1.609" "4" "1" "1" "1" "184" "20.5" "6.55" "0.00" "1" "" "" "" "Pf13855" "55222" "ENSG00000172731" "LRRC20" "hsa:55222; Q5T6D4; Q5T6D6; Q8TCA0; Q9NVA6; Q9NVG3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9120787877776140146" "False" "Medium" "IsMasterProtein" "Q17RS7" "Flap endonuclease GEN homolog 1 OS=Homo sapiens OX=9606 GN=GEN1 PE=1 SV=2" "0.019" "False" "1.608" "1" "1" "1" "1" "908" "102.8" "7.81" "0.00" "1" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf00752, Pf00867, Pf18704" "348654" "ENSG00000178295" "GEN1" "hsa:348654; Q17RS7; Q17RS9; Q6ZN37" "" "Resolution of D-loop Structures through Holliday Junction Intermediates" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7563735417890983721" "False" "Medium" "IsMasterProtein" "P41208" "Centrin-2 OS=Homo sapiens OX=9606 GN=CETN2 PE=1 SV=1" "0.019" "False" "1.607" "5" "1" "1" "1" "172" "19.7" "5.00" "1.72" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf13499" "1069" "ENSG00000147400; ENSG00000292191" "CETN2" "B2R4T4; hsa:1069; P41208; Q53XW1" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; SUMOylation of DNA damage response and repair proteins; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "13" "0" "0.714" "0.781" "1.048" "1.063" "0.713" "0.990" "0.859" "0.729" "0.592" "41.9" "29.9" "32.7" "43.9" "44.5" "29.9" "41.4" "36.0" "30.5" "24.8" "" "" "" "" "" "" "" "" "" "" "22.2" "16.6" "18.7" "20.2" "24.1" "16.6" "24.4" "19.6" "17.1" "24.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-21239567639981216" "False" "Medium" "IsMasterProtein" "Q9BRA0" "N-alpha-acetyltransferase 38, NatC auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA38 PE=1 SV=1" "0.019" "False" "1.605" "7" "1" "1" "1" "125" "13.5" "5.53" "2.12" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "84316" "ENSG00000183011" "NAA38" "hsa:84316; Q8N4M0; Q9BRA0" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "1.118" "1.160" "1.774" "1.403" "1.257" "1.348" "0.929" "1.251" "1.435" "30.5" "34.1" "35.4" "54.1" "42.8" "38.3" "41.1" "28.3" "38.2" "43.8" "" "" "" "" "" "" "" "" "" "" "16.2" "18.9" "20.3" "24.9" "23.1" "21.3" "24.2" "15.5" "21.4" "43.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5677827102624180499" "False" "Medium" "IsMasterProtein" "Q96IQ9" "Zinc finger protein 414 OS=Homo sapiens OX=9606 GN=ZNF414 PE=1 SV=2" "0.019" "False" "1.605" "2" "1" "1" "1" "312" "32.8" "7.81" "2.66" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf15909" "84330" "ENSG00000133250" "ZNF414" "A8MY94; hsa:84330; Q96IQ9" "" "" "0" "0" "1.052" "1.154" "1.136" "1.087" "1.137" "1.156" "0.999" "1.253" "1.752" "91.7" "96.4" "105.9" "104.1" "99.7" "104.3" "106.0" "91.6" "114.9" "160.7" "" "" "" "" "" "" "" "" "" "" "48.6" "53.5" "60.6" "48.0" "53.9" "58.0" "62.4" "50.0" "64.4" "160.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1884707447535219714" "False" "Medium" "IsMasterProtein" "Q9BYM8" "RanBP-type and C3HC4-type zinc finger-containing protein 1 OS=Homo sapiens OX=9606 GN=RBCK1 PE=1 SV=2" "0.019" "False" "1.605" "2" "1" "1" "1" "510" "57.5" "5.67" "0.00" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13445" "10616" "ENSG00000125826" "RBCK1" "O95623; Q86SL2; Q96BS3; Q9BYM8; Q9BYM9" "TAR syndrome" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3945709348519994010" "False" "Medium" "IsMasterProtein" "Q96I23" "Protein preY, mitochondrial OS=Homo sapiens OX=9606 GN=PYURF PE=1 SV=1" "0.019" "False" "1.604" "7" "1" "1" "1" "114" "12.6" "9.33" "0.00" "1" "other biological processes" "other membranes;mitochondrion;ER/Golgi" "" "Pf03966" "100996939" "ENSG00000145337" "PYURF" "B2R571; hsa:100996939; Q96I23" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7193006911186956022" "False" "Medium" "IsMasterProtein" "Q9NVU7" "Protein SDA1 homolog OS=Homo sapiens OX=9606 GN=SDAD1 PE=1 SV=3" "0.019" "False" "1.602" "1" "1" "1" "1" "687" "79.8" "9.25" "2.25" "1" "transport;other biological processes" "nucleus" "" "Pf05285, Pf08158, Pf21638" "55153" "ENSG00000198301" "SDAD1" "hsa:55153; Q32Q11; Q68D52; Q7Z5U4; Q9H831; Q9H9P6; Q9NVU7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7610728054593455927" "False" "Medium" "IsMasterProtein" "Q86SZ2" "Trafficking protein particle complex subunit 6B OS=Homo sapiens OX=9606 GN=TRAPPC6B PE=1 SV=1" "0.019" "False" "1.599" "5" "1" "1" "1" "158" "18.0" "8.68" "0.00" "1" "cell organization and biogenesis;transport;developmental processes" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04051" "122553" "ENSG00000182400" "TRAPPC6B" "B3KPS2; hsa:122553; Q5JPD6; Q86SZ2; Q86U35; Q86X35" "" "COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs" "2" "0" "1.210" "1.378" "1.276" "1.310" "1.349" "1.324" "1.258" "1.187" "1.110" "72.6" "87.9" "100.1" "92.7" "95.2" "98.0" "96.2" "91.4" "86.2" "80.7" "" "" "" "" "" "" "" "" "" "" "38.5" "48.7" "57.3" "42.7" "51.5" "54.5" "56.6" "49.9" "48.4" "80.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-325919897552027140" "False" "Medium" "IsMasterProtein" "Q9NW08" "DNA-directed RNA polymerase III subunit RPC2 OS=Homo sapiens OX=9606 GN=POLR3B PE=1 SV=2" "0.019" "False" "1.596" "1" "1" "1" "1" "1133" "127.7" "8.50" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf04566, Pf04567" "55703" "ENSG00000013503" "POLR3B" "A8K6H0; B3KV73; F5H1E6; hsa:55703; Q9NW08; Q9NW59" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "10" "0" "1.068" "1.143" "1.222" "1.185" "1.064" "1.028" "1.054" "1.009" "0.827" "123.4" "131.9" "141.0" "150.9" "146.3" "131.3" "126.8" "130.1" "124.5" "102.1" "" "" "" "" "" "" "" "" "" "" "65.3" "73.1" "80.8" "69.5" "79.1" "73.1" "74.6" "71.0" "69.8" "102.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6859898676853131863" "False" "Medium" "IsMasterProtein" "Q96IR2" "Zinc finger protein 845 OS=Homo sapiens OX=9606 GN=ZNF845 PE=1 SV=3" "0.019" "False" "1.594" "1" "1" "1" "1" "970" "113.1" "9.33" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "91664" "ENSG00000213799" "ZNF845" "hsa:91664; Q96IR2" "" "" "0" "0" "1.122" "1.022" "1.079" "1.112" "1.045" "1.070" "0.887" "0.965" "1.111" "100.5" "112.8" "102.8" "108.5" "111.8" "105.1" "107.6" "89.2" "97.0" "111.7" "" "" "" "" "" "" "" "" "" "" "53.2" "62.5" "58.9" "50.0" "60.5" "58.5" "63.3" "48.7" "54.4" "111.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1610110799858015964" "False" "Medium" "IsMasterProtein" "P20674" "Cytochrome c oxidase subunit 5A, mitochondrial OS=Homo sapiens OX=9606 GN=COX5A PE=1 SV=2" "0.019" "False" "1.594" "5" "1" "2" "1" "150" "16.8" "6.79" "4.30" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf02284" "9377" "ENSG00000178741" "COX5A" "hsa:9377; P20674; P30045; Q8TB65" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation; Arachidonate epoxygenase / epoxide hydrolase" "Respiratory electron transport; Mitochondrial protein degradation; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8654378889917812669" "False" "Medium" "IsMasterProtein" "Q9BQ90" "Kelch domain-containing protein 3 OS=Homo sapiens OX=9606 GN=KLHDC3 PE=1 SV=1" "0.019" "False" "1.594" "2" "1" "1" "1" "382" "43.1" "8.07" "2.68" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01344, Pf07646, Pf13418, Pf13964" "116138" "ENSG00000124702" "KLHDC3" "A8K2W9; hsa:116138; Q9BQ90" "" "XBP1(S) activates chaperone genes" "1" "0" "1.105" "1.016" "1.138" "1.097" "0.980" "1.075" "0.964" "1.022" "0.910" "209.9" "231.9" "213.4" "238.8" "230.3" "205.7" "225.7" "202.3" "214.5" "191.1" "" "" "" "" "" "" "" "" "" "" "111.1" "128.6" "122.2" "110.0" "124.6" "114.4" "132.8" "110.4" "120.3" "191.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4457923418212220439" "False" "Medium" "IsMasterProtein" "O60499" "Syntaxin-10 OS=Homo sapiens OX=9606 GN=STX10 PE=1 SV=1" "0.019" "False" "1.594" "6" "1" "1" "1" "249" "28.1" "4.89" "2.68" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf05739, Pf09177" "8677" "ENSG00000104915" "STX10" "A6NC41; hsa:8677; O60499; Q6IAP4; Q96AE8" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5274992111862833065" "False" "Medium" "IsMasterProtein" "Q8IXJ6" "NAD-dependent protein deacetylase sirtuin-2 OS=Homo sapiens OX=9606 GN=SIRT2 PE=1 SV=2" "0.019" "False" "1.593" "2" "1" "1" "1" "389" "43.2" "5.36" "2.51" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf02146" "22933" "ENSG00000068903; ENSG00000283100" "SIRT2" "A8K3V1; B2RB45; hsa:22933; O95889; Q8IXJ6; Q924Y7; Q9P0G8; Q9UNT0; Q9Y6E9; U5TP13" "NAD+ metabolism; NAD+ biosynthetic pathways; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; HDAC6 interactions in the central nervous system" "Initiation of Nuclear Envelope (NE) Reformation" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2991903496179440797" "False" "Medium" "IsMasterProtein" "A8CG34" "Nuclear envelope pore membrane protein POM 121C OS=Homo sapiens OX=9606 GN=POM121C PE=1 SV=3" "0.020" "False" "1.592" "1" "1" "1" "1" "1229" "125.0" "10.37" "2.24" "1" "transport" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf15229" "" "ENSG00000272391" "POM121C" "A0A075B7F8; A0A087WY75; A8CG34; O75115; Q9Y2N3; Q9Y4S7" "" "HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "28" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1459821259298876013" "False" "Medium" "IsMasterProtein" "Q30KR1" "Putative beta-defensin 109B OS=Homo sapiens OX=9606 GN=DEFB109B PE=5 SV=1" "0.020" "False" "1.588" "17" "1" "2" "1" "87" "9.9" "8.53" "5.38" "1" "stress response;signal transduction;other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding" "" "" "ENSG00000206034" "DEFB109B" "Q30KR1" "" "Beta defensins" "1" "0" "0.924" "1.053" "1.027" "0.861" "0.815" "0.694" "0.838" "0.943" "0.767" "46.7" "43.1" "49.2" "48.0" "40.2" "38.0" "32.4" "39.1" "44.0" "35.8" "" "" "" "" "" "" "" "" "" "" "24.7" "23.9" "28.2" "22.1" "21.8" "21.2" "19.1" "21.4" "24.7" "35.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4622932999208517122" "False" "Medium" "IsMasterProtein" "Q96HR8" "H/ACA ribonucleoprotein complex non-core subunit NAF1 OS=Homo sapiens OX=9606 GN=NAF1 PE=1 SV=2" "0.020" "False" "1.587" "1" "1" "1" "1" "494" "53.7" "4.87" "2.80" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04410" "92345" "ENSG00000145414" "NAF1" "D3DP28; E9PAZ2; hsa:92345; Q96HR8" "" "" "0" "0" "0.612" "0.631" "0.584" "0.642" "0.947" "0.615" "0.606" "0.606" "0.674" "799.4" "489.3" "504.4" "466.7" "513.1" "756.8" "492.0" "484.1" "484.7" "538.8" "" "" "" "" "" "" "" "" "" "" "423.3" "271.3" "288.9" "214.9" "277.6" "421.0" "289.5" "264.3" "271.9" "538.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8494300980345175756" "False" "Medium" "IsMasterProtein" "P48059" "LIM and senescent cell antigen-like-containing domain protein 1 OS=Homo sapiens OX=9606 GN=LIMS1 PE=1 SV=4" "0.020" "False" "1.583" "2" "1" "1" "1" "325" "37.2" "8.05" "2.60" "1" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00412" "3987" "ENSG00000169756" "LIMS1" "B2RAJ4; B7Z483; B7Z7R3; B7Z907; hsa:3987; P48059; Q53TE0; Q9BS44" "Primary focal segmental glomerulosclerosis (FSGS)" "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "3" "0" "1.023" "1.068" "1.125" "1.114" "1.120" "1.006" "1.116" "1.038" "1.109" "202.5" "207.1" "216.3" "227.8" "225.7" "226.8" "203.7" "225.9" "210.2" "224.6" "" "" "" "" "" "" "" "" "" "" "107.2" "114.8" "123.9" "104.9" "122.1" "126.2" "119.9" "123.3" "117.9" "224.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "408480103546989940" "False" "Medium" "IsMasterProtein" "Q9Y4C1" "Lysine-specific demethylase 3A OS=Homo sapiens OX=9606 GN=KDM3A PE=1 SV=4" "0.020" "False" "1.583" "1" "1" "1" "1" "1321" "147.2" "8.07" "2.16" "1" "cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "55818" "ENSG00000115548" "KDM3A" "D6W5M3; hsa:55818; Q53S72; Q68D47; Q68UT9; Q6N050; Q8IY08; Q9Y4C1" "Thermogenesis; Male infertility; Vitamin D-sensitive calcium signaling in depression" "HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" "5" "0" "1.057" "0.976" "1.177" "1.099" "0.975" "1.725" "1.767" "1.543" "1.467" "188.4" "199.1" "184.0" "221.9" "207.0" "183.7" "325.1" "332.9" "290.7" "276.4" "" "" "" "" "" "" "" "" "" "" "99.8" "110.4" "105.4" "102.2" "112.0" "102.2" "191.3" "181.7" "163.1" "276.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8116747825737560157" "False" "Medium" "IsMasterProtein" "O15235" "Small ribosomal subunit protein uS12m OS=Homo sapiens OX=9606 GN=MRPS12 PE=1 SV=1" "0.020" "False" "1.582" "6" "1" "1" "1" "138" "15.2" "10.29" "2.23" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00164" "6183" "ENSG00000128626; ENSG00000283018" "MRPS12" "hsa:6183; O15235; Q53X98" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.190" "1.057" "1.312" "1.229" "1.058" "1.069" "0.907" "1.086" "3.145" "101.7" "121.1" "107.5" "133.5" "125.0" "107.7" "108.8" "92.3" "110.5" "319.9" "" "" "" "" "" "" "" "" "" "" "53.9" "67.1" "61.6" "61.5" "67.6" "59.9" "64.0" "50.4" "62.0" "319.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3949732143901396407" "False" "Medium" "IsMasterProtein" "O43427" "Acidic fibroblast growth factor intracellular-binding protein OS=Homo sapiens OX=9606 GN=FIBP PE=1 SV=3" "0.021" "False" "1.578" "2" "1" "1" "1" "364" "41.9" "6.48" "2.23" "1" "signal transduction" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf05427" "9158" "ENSG00000172500" "FIBP" "A8K0J7; hsa:9158; O43427; Q27Q85; Q6IBQ3; Q9HD65" "Modulators of TCR signaling and T cell activation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4850932002920581345" "False" "Medium" "IsMasterProtein" "Q96GX5" "Serine/threonine-protein kinase greatwall OS=Homo sapiens OX=9606 GN=MASTL PE=1 SV=1" "0.021" "False" "1.576" "1" "1" "1" "1" "879" "97.3" "5.99" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "84930" "ENSG00000120539" "MASTL" "hsa:84930; Q5T8D5; Q5T8D7; Q8NCD6; Q96GX5; Q96SJ5" "" "MASTL Facilitates Mitotic Progression" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6011975362988594492" "False" "Medium" "IsMasterProtein" "Cont_Q3T052" "Inter-alpha-trypsin inhibitor heavy chain H4 OS=Bos taurus OX=9913 GN=ITIH4 PE=1 SV=1" "0.021" "True" "1.572" "1" "1" "1" "1" "916" "101.4" "6.68" "2.09" "1" "other metabolic processes;stress response" "non-structural extracellular" "enzyme regulator activity" "Pf00092, Pf06668, Pf08487" "513700" "" "ITIH4" "bta:513700; Q3T052" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2257664793413269493" "False" "Medium" "IsMasterProtein" "Q69YN2" "CWF19-like protein 1 OS=Homo sapiens OX=9606 GN=CWF19L1 PE=1 SV=2" "0.021" "False" "1.571" "2" "1" "1" "1" "538" "60.6" "7.24" "2.04" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "enzyme regulator activity" "Pf04676, Pf04677" "55280" "ENSG00000095485" "CWF19L1" "B4DHX1; D3DR66; hsa:55280; Q5W0I3; Q69YN2; Q96HC3; Q9H865; Q9NV13" "" "" "0" "0" "1.122" "1.074" "1.227" "1.395" "1.256" "1.343" "1.429" "1.141" "1.106" "32.5" "36.5" "34.9" "39.9" "45.3" "40.8" "43.7" "46.5" "37.1" "35.9" "" "" "" "" "" "" "" "" "" "" "17.2" "20.2" "20.0" "18.4" "24.5" "22.7" "25.7" "25.4" "20.8" "35.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3275196182656961977" "False" "Medium" "IsMasterProtein" "Q8WXB1" "Protein N-lysine methyltransferase METTL21A OS=Homo sapiens OX=9606 GN=METTL21A PE=1 SV=2" "0.021" "False" "1.570" "5" "1" "1" "1" "218" "24.6" "6.27" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf10294" "151194" "ENSG00000144401" "METTL21A" "hsa:151194; Q53RV0; Q8N1Z9; Q8WXB1; Q96GH6" "" "Protein methylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6658227745558527027" "False" "Medium" "IsMasterProtein" "Q9NP71" "Carbohydrate-responsive element-binding protein OS=Homo sapiens OX=9606 GN=MLXIPL PE=1 SV=1" "0.022" "False" "1.568" "1" "1" "1" "1" "852" "93.0" "8.41" "0.00" "1" "other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "51085" "ENSG00000009950" "MLXIPL" "C5HU02; C5HU03; C5HU04; hsa:51085; Q96E48; Q9BY03; Q9BY04; Q9BY05; Q9BY06; Q9NP71; Q9Y2P3" "Angiopoietin-like protein 8 regulatory pathway; Nonalcoholic fatty liver disease; 7q11.23 copy number variation syndrome" "ChREBP activates metabolic gene expression; AMPK inhibits chREBP transcriptional activation activity; PKA-mediated phosphorylation of key metabolic factors; PP2A-mediated dephosphorylation of key metabolic factors" "7" "0" "0.988" "1.768" "1.114" "1.654" "1.007" "1.257" "0.896" "1.201" "5.671" "17.9" "17.7" "31.7" "20.0" "29.7" "18.1" "22.6" "16.1" "21.6" "101.8" "" "" "" "" "" "" "" "" "" "" "9.5" "9.8" "18.2" "9.2" "16.1" "10.1" "13.3" "8.8" "12.1" "101.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1334923261795063167" "False" "Medium" "IsMasterProtein" "P09467" "Fructose-1,6-bisphosphatase 1 OS=Homo sapiens OX=9606 GN=FBP1 PE=1 SV=5" "0.022" "False" "1.562" "2" "1" "1" "1" "338" "36.8" "6.99" "2.52" "1" "other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00316, Pf18913" "2203" "ENSG00000165140" "FBP1" "hsa:2203; O75571; P09467; Q53F94; Q96E46" "Angiopoietin-like protein 8 regulatory pathway; Disorders of fructose metabolism; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Gluconeogenesis" "5" "0" "0.934" "0.885" "1.027" "0.928" "1.074" "0.882" "1.059" "1.039" "0.783" "170.4" "159.1" "150.8" "175.0" "158.1" "183.1" "150.2" "180.6" "177.0" "133.4" "" "" "" "" "" "" "" "" "" "" "90.2" "88.2" "86.3" "80.6" "85.6" "101.8" "88.4" "98.6" "99.3" "133.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1892003299666365822" "False" "Medium" "IsMasterProtein" "P60484" "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Homo sapiens OX=9606 GN=PTEN PE=1 SV=1" "0.022" "False" "1.561" "2" "1" "1" "1" "403" "47.1" "6.37" "1.99" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00102, Pf10409" "5728" "ENSG00000171862; ENSG00000284792" "PTEN" "B2R904; F2YHV0; O00633; O02679; P60484; Q6ICT7" "Androgen receptor signaling pathway; Leptin signaling pathway; Microtubule cytoskeleton regulation; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; T cell receptor and co-stimulatory signaling; Focal adhesion; Hepatocyte growth factor receptor signaling; Copper homeostasis; MECP2 and associated Rett syndrome; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of p53 pathway in prostate cancer; Clear cell renal cell carcinoma pathways; Endometrial cancer; PI3K-Akt signaling pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Breast cancer pathway; Extracellular vesicles in the crosstalk of cardiac cells; EGF/EGFR signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; 16p11.2 proximal deletion syndrome; p53 transcriptional gene network; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; Urotensin-II-mediated signaling pathway; TROP2 regulatory signaling; Primary ovarian insufficiency; Macrophage-stimulating protein (MSP) signaling network map; DNA damage response (only ATM dependent)" "TP53 Regulates Metabolic Genes; Regulation of PTEN stability and activity; Downstream TCR signaling; Ub-specific processing proteases; Transcriptional Regulation by MECP2; Synthesis of PIPs at the plasma membrane; Synthesis of IP3 and IP4 in the cytosol; Ovarian tumor domain proteases; Negative regulation of the PI3K/AKT network; Regulation of PTEN localization; PTEN Loss of Function in Cancer; Regulation of PTEN mRNA translation" "55" "0" "0.864" "0.839" "0.978" "0.919" "0.621" "0.850" "0.658" "0.814" "2.122" "77.2" "66.7" "64.8" "75.5" "70.9" "47.9" "65.6" "50.8" "62.9" "163.8" "" "" "" "" "" "" "" "" "" "" "40.9" "37.0" "37.1" "34.8" "38.4" "26.7" "38.6" "27.7" "35.3" "163.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1940772277811891477" "False" "Medium" "IsMasterProtein" "Q96PM5" "RING finger and CHY zinc finger domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RCHY1 PE=1 SV=1" "0.022" "False" "1.560" "3" "1" "1" "1" "261" "30.1" "6.71" "0.00" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05495, Pf13639, Pf14599" "25898" "ENSG00000163743" "RCHY1" "B3KRG3; C7E541; C7E542; C7E543; D3YRV2; E7EMC8; E7ETW5; J3KPI0; Q2KN33; Q59GN7; Q86X26; Q96PM5; Q96PR5" "Measles virus infection" "Antigen processing: Ubiquitination & Proteasome degradation; Translesion Synthesis by POLH" "3" "0" "0.810" "0.875" "1.005" "0.944" "0.917" "0.953" "1.027" "0.874" "0.602" "76.2" "61.7" "66.7" "76.6" "71.9" "69.9" "72.6" "78.3" "66.6" "45.9" "" "" "" "" "" "" "" "" "" "" "40.3" "34.2" "38.2" "35.3" "38.9" "38.9" "42.7" "42.7" "37.4" "45.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5403198551536365946" "False" "Medium" "IsMasterProtein" "Q14692" "Ribosome biogenesis protein BMS1 homolog OS=Homo sapiens OX=9606 GN=BMS1 PE=1 SV=1" "0.023" "False" "1.556" "1" "1" "1" "1" "1282" "145.7" "6.44" "1.75" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04950, Pf08142" "9790" "ENSG00000165733" "BMS1" "hsa:9790; Q14692; Q5QPT5; Q86XJ9" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "735659524784303490" "False" "Medium" "IsMasterProtein" "Q8IV50" "LysM and putative peptidoglycan-binding domain-containing protein 2 OS=Homo sapiens OX=9606 GN=LYSMD2 PE=1 SV=1" "0.023" "False" "1.555" "5" "1" "1" "1" "215" "23.4" "5.35" "1.98" "1" "" "" "" "Pf01476" "256586" "ENSG00000140280" "LYSMD2" "hsa:256586; Q5CZ88; Q8IV50; Q8WTV3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1117159967779804568" "False" "Medium" "IsMasterProtein" "Q7L4I2" "Arginine/serine-rich coiled-coil protein 2 OS=Homo sapiens OX=9606 GN=RSRC2 PE=1 SV=1" "0.023" "False" "1.552" "2" "1" "1" "1" "434" "50.5" "11.33" "2.39" "1" "" "" "" "Pf15477" "65117" "ENSG00000111011" "RSRC2" "hsa:65117; Q6N040; Q6NW16; Q7L4I2; Q9H864" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6634047056467408227" "False" "Medium" "IsMasterProtein" "P62318" "Small nuclear ribonucleoprotein Sm D3 OS=Homo sapiens OX=9606 GN=SNRPD3 PE=1 SV=1" "0.023" "False" "1.550" "7" "1" "2" "1" "126" "13.9" "10.32" "0.00" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "6634" "ENSG00000100028" "SNRPD3" "B4DJP7; B5BU13; hsa:6634; P43331; P62318" "mRNA processing" "SARS-CoV-2 modulates host translation machinery; snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "8" "0" "1.048" "0.834" "1.132" "0.901" "0.800" "0.918" "0.886" "0.915" "0.539" "43.5" "45.6" "36.3" "49.3" "39.2" "34.8" "40.0" "38.6" "39.9" "23.5" "" "" "" "" "" "" "" "" "" "" "23.1" "25.3" "20.8" "22.7" "21.2" "19.4" "23.5" "21.1" "22.4" "23.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8694247867552348247" "False" "Medium" "IsMasterProtein" "Q9BQ75" "Protein CMSS1 OS=Homo sapiens OX=9606 GN=CMSS1 PE=1 SV=2" "0.023" "False" "1.548" "3" "1" "1" "1" "279" "31.9" "9.19" "2.50" "1" "" "" "" "Pf14617" "84319" "ENSG00000184220" "CMSS1" "A8K5S7; B4DUM1; E9PHS3; hsa:84319; Q9BQ75" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3574158792208652274" "False" "Medium" "IsMasterProtein" "O96028" "Histone-lysine N-methyltransferase NSD2 OS=Homo sapiens OX=9606 GN=NSD2 PE=1 SV=1" "0.023" "False" "1.543" "1" "1" "1" "1" "1365" "152.2" "8.69" "2.16" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf00628, Pf00855, Pf00856, Pf17907, Pf17982" "7468" "ENSG00000109685" "NSD2" "A2A2T2; A2A2T3; A2A2T4; A7MCZ1; D3DVQ2; hsa:7468; O96028; O96031; Q4VBY8; Q672J1; Q6IS00; Q86V01; Q9BZB4; Q9UI92; Q9UPR2" "4p16.3 copy number variation" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; PKMTs methylate histone lysines; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6039342044264890236" "False" "Medium" "IsMasterProtein" "Q99808" "Equilibrative nucleoside transporter 1 OS=Homo sapiens OX=9606 GN=SLC29A1 PE=1 SV=3" "0.023" "False" "1.538" "2" "1" "1" "1" "456" "50.2" "8.29" "1.63" "1" "cell-cell signaling;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf01733" "2030" "ENSG00000112759" "SLC29A1" "B3KQV7; B3KQY5; hsa:2030; Q5T9W9; Q99808; Q9UJY2" "Fluoropyrimidine activity" "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; Azathioprine ADME; Ribavirin ADME" "4" "0" "1.323" "1.074" "1.272" "0.963" "1.242" "1.298" "1.255" "1.024" "0.459" "51.2" "67.7" "55.0" "65.1" "49.3" "63.6" "66.4" "64.2" "52.4" "23.5" "" "" "" "" "" "" "" "" "" "" "27.1" "37.5" "31.5" "30.0" "26.7" "35.4" "39.1" "35.1" "29.4" "23.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8893850793131937072" "False" "Medium" "IsMasterProtein" "O95749" "Geranylgeranyl pyrophosphate synthase OS=Homo sapiens OX=9606 GN=GGPS1 PE=1 SV=1" "0.023" "False" "1.535" "3" "1" "1" "1" "300" "34.8" "6.14" "0.00" "1" "other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00348" "9453" "ENSG00000152904" "GGPS1" "A8MVQ8; hsa:9453; O95749; Q5T2C8; Q6NW19" "Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis pathway in hepatocytes" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-726538263945454181" "False" "Medium" "IsMasterProtein" "Q01459" "Di-N-acetylchitobiase OS=Homo sapiens OX=9606 GN=CTBS PE=1 SV=1" "0.023" "False" "1.535" "2" "1" "1" "1" "385" "43.7" "6.64" "0.00" "1" "other metabolic processes" "other cytoplasmic organelle" "other molecular function" "Pf00704" "1486" "ENSG00000117151" "CTBS" "hsa:1486; Q01459; Q5VX50" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8488452650529328010" "False" "Medium" "IsMasterProtein" "Q5VIR6" "Vacuolar protein sorting-associated protein 53 homolog OS=Homo sapiens OX=9606 GN=VPS53 PE=1 SV=2" "0.023" "False" "1.527" "1" "1" "1" "1" "832" "94.3" "6.70" "1.96" "1" "transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04100, Pf16854" "55275" "ENSG00000141252; ENSG00000283883" "VPS53" "A8K2S8; B3FH42; hsa:55275; Q5VIR6; Q8WYW3; Q9BRR2; Q9BY02; Q9NV25" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "1.123" "1.183" "0.873" "1.093" "1.173" "1.386" "1.163" "1.089" "3.137" "65.0" "73.0" "76.9" "56.8" "71.1" "76.3" "90.1" "75.6" "70.8" "204.0" "" "" "" "" "" "" "" "" "" "" "34.4" "40.5" "44.1" "26.1" "38.4" "42.4" "53.1" "41.3" "39.7" "204.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5625038226073765913" "False" "Medium" "IsMasterProtein" "P61421" "V-type proton ATPase subunit d 1 OS=Homo sapiens OX=9606 GN=ATP6V0D1 PE=1 SV=1" "0.023" "False" "1.525" "2" "1" "1" "1" "351" "40.3" "5.00" "0.00" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf01992" "9114" "ENSG00000159720" "ATP6V0D1" "hsa:9114; P12953; P61421; Q02547" "VEGFA-VEGFR2 signaling" "Amino acids regulate mTORC1; XBP1(S) activates chaperone genes; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2959311852295820305" "False" "Medium" "IsMasterProtein" "Q6TFL3" "Coiled-coil domain-containing protein 171 OS=Homo sapiens OX=9606 GN=CCDC171 PE=1 SV=1" "0.023" "False" "1.519" "1" "1" "2" "1" "1326" "152.7" "6.81" "0.00" "1" "" "" "" "" "203238" "ENSG00000164989" "CCDC171" "B7ZM22; Q5SU58; Q6P1W1; Q6TFL3; Q6ZR13; Q8N1Z4; Q8N8L3; Q8TBR2" "" "" "0" "0" "1.018" "0.924" "1.234" "1.209" "1.063" "1.210" "0.917" "1.143" "0.675" "27.1" "27.6" "25.0" "33.4" "32.8" "28.8" "32.8" "24.9" "31.0" "18.3" "" "" "" "" "" "" "" "" "" "" "14.3" "15.3" "14.3" "15.4" "17.7" "16.0" "19.3" "13.6" "17.4" "18.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3672343249527762985" "False" "Medium" "IsMasterProtein" "Q9H8M7" "Ubiquitin carboxyl-terminal hydrolase MINDY-3 OS=Homo sapiens OX=9606 GN=MINDY3 PE=1 SV=1" "0.024" "False" "1.516" "2" "1" "1" "1" "445" "49.7" "4.77" "1.71" "1" "protein metabolism;other biological processes" "other membranes;nucleus" "other molecular function" "Pf13898" "80013" "ENSG00000148481" "MINDY3" "Q5SZ68; Q5SZ69; Q5SZ70; Q6IA40; Q6P7P0; Q7Z2S1; Q8WUF1; Q9H3I4; Q9H8M7" "" "" "0" "0" "0.969" "0.936" "0.962" "0.964" "1.183" "1.018" "0.946" "0.812" "0.690" "56.4" "54.7" "52.8" "54.2" "54.3" "66.7" "57.4" "53.3" "45.8" "38.9" "" "" "" "" "" "" "" "" "" "" "29.9" "30.3" "30.2" "25.0" "29.4" "37.1" "33.8" "29.1" "25.7" "38.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5714839518332735956" "False" "Medium" "IsMasterProtein" "M0QZD8" "Vitellogenin domain-containing protein OS=Homo sapiens OX=9606 GN=LOC400499 PE=4 SV=3" "0.024" "False" "1.510" "0" "1" "1" "1" "3266" "357.6" "7.85" "2.54" "1" "transport" "" "transporter activity" "Pf00094, Pf01347, Pf09172, Pf21013" "" "ENSG00000188897" "LOC400499" "M0QZD8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-852377223734167343" "False" "Medium" "IsMasterProtein" "Q4G176" "Malonate--CoA ligase ACSF3, mitochondrial OS=Homo sapiens OX=9606 GN=ACSF3 PE=1 SV=3" "0.024" "False" "1.505" "1" "1" "1" "1" "576" "64.1" "8.37" "2.72" "1" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00501, Pf13193" "197322" "ENSG00000176715" "ACSF3" "A8K4J8; C9JQL6; hsa:197322; Q4G176; Q6INA0; Q8N2F7" "" "Synthesis of very long-chain fatty acyl-CoAs" "1" "0" "1.011" "1.166" "1.035" "1.004" "1.090" "1.122" "0.766" "0.982" "3.121" "110.4" "111.6" "128.7" "114.2" "110.8" "120.3" "123.8" "84.6" "108.4" "344.5" "" "" "" "" "" "" "" "" "" "" "58.4" "61.9" "73.7" "52.6" "59.9" "66.9" "72.9" "46.2" "60.8" "344.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1851911761268984934" "False" "Medium" "IsMasterProtein" "O00418" "Eukaryotic elongation factor 2 kinase OS=Homo sapiens OX=9606 GN=EEF2K PE=1 SV=2" "0.024" "False" "1.504" "1" "1" "1" "1" "725" "82.1" "5.33" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf02816" "29904" "ENSG00000103319" "EEF2K" "hsa:29904; O00418; Q8N588" "Translation factors; AMP-activated protein kinase signaling; BDNF-TrkB signaling" "mTORC1-mediated signalling" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6903887554392062573" "False" "Medium" "IsMasterProtein" "P35226" "Polycomb complex protein BMI-1 OS=Homo sapiens OX=9606 GN=BMI1 PE=1 SV=2" "0.024" "False" "1.502" "2" "1" "1" "1" "326" "36.9" "8.63" "1.86" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf13923, Pf16207" "100532731; 648" "ENSG00000168283" "BMI1" "hsa:100532731; hsa:648; P35226; Q16030; Q5T8Z3; Q96F37" "Pleural mesothelioma; Interactions of natural killer cells in pancreatic cancer; CCL18 signaling pathway" "SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Oxidative Stress Induced Senescence; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6" "12" "0" "0.933" "1.005" "1.135" "1.111" "1.095" "1.494" "1.569" "1.466" "1.783" "84.3" "78.6" "84.7" "95.7" "93.7" "92.3" "126.0" "132.3" "123.6" "150.3" "" "" "" "" "" "" "" "" "" "" "44.6" "43.6" "48.5" "44.1" "50.7" "51.3" "74.1" "72.2" "69.3" "150.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8090772672849701149" "False" "Medium" "IsMasterProtein" "Q53FZ2" "Acyl-coenzyme A synthetase ACSM3, mitochondrial OS=Homo sapiens OX=9606 GN=ACSM3 PE=1 SV=2" "0.024" "False" "1.501" "1" "1" "1" "1" "586" "66.1" "9.04" "2.12" "1" "other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf00501, Pf13193" "6296" "ENSG00000005187" "ACSM3" "hsa:6296; O60363; Q13732; Q15425; Q53FZ2; Q7KYM6; Q9BUA2" "" "Beta oxidation of butanoyl-CoA to acetyl-CoA" "1" "0" "1.186" "1.103" "1.330" "1.078" "1.210" "1.337" "0.367" "0.736" "6.704" "29.1" "34.5" "32.1" "38.7" "31.4" "35.2" "38.9" "10.7" "21.4" "195.1" "" "" "" "" "" "" "" "" "" "" "15.4" "19.1" "18.4" "17.8" "17.0" "19.6" "22.9" "5.8" "12.0" "195.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4690988044632206279" "False" "Medium" "IsMasterProtein" "Q16719" "Kynureninase OS=Homo sapiens OX=9606 GN=KYNU PE=1 SV=1" "0.024" "False" "1.500" "2" "1" "1" "1" "465" "52.3" "7.03" "2.07" "1" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00266" "8942" "ENSG00000115919" "KYNU" "B2RCZ5; D3DP79; hsa:8942; Q16719; Q6I9T2; Q9BVW3" "Selenium micronutrient network; NAD biosynthesis II (from tryptophan); Tryptophan metabolism" "Tryptophan catabolism" "4" "0" "0.956" "0.845" "0.946" "1.052" "0.943" "0.956" "0.869" "1.010" "0.573" "66.4" "63.5" "56.1" "62.8" "69.8" "62.6" "63.5" "57.7" "67.0" "38.0" "" "" "" "" "" "" "" "" "" "" "35.2" "35.2" "32.1" "28.9" "37.8" "34.8" "37.4" "31.5" "37.6" "38.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-345522786131708725" "False" "Medium" "IsMasterProtein" "Q14571" "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 OS=Homo sapiens OX=9606 GN=ITPR2 PE=1 SV=2" "0.024" "False" "1.500" "0" "1" "1" "1" "2701" "307.9" "6.43" "2.15" "1" "stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00520, Pf01365, Pf02815, Pf08454, Pf08709" "3709" "ENSG00000123104" "ITPR2" "hsa:3709; O94773; Q14571" "Alzheimer's disease and miRNA effects; Myometrial relaxation and contraction pathways; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects; Alzheimer's disease; GDNF signaling; Calcium regulation in cardiac cells" "Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Ca2+ pathway; VEGFR2 mediated cell proliferation; Elevation of cytosolic Ca2+ levels; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation; Effects of PIP2 hydrolysis" "21" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1538396539459298741" "False" "Medium" "IsMasterProtein" "Q9H6Q4" "Cytosolic iron-sulfur assembly component 3 OS=Homo sapiens OX=9606 GN=CIAO3 PE=1 SV=1" "0.024" "False" "1.498" "2" "1" "1" "1" "476" "53.0" "7.23" "0.00" "1" "cell organization and biogenesis;stress response;other biological processes" "other cell component" "other molecular function" "Pf02256, Pf02906" "64428" "ENSG00000103245" "CIAO3" "A1L385; B3KTJ3; hsa:64428; Q53GC6; Q96S10; Q9H6J8; Q9H6Q4" "" "Cytosolic iron-sulfur cluster assembly" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1059597510691601" "False" "Medium" "IsMasterProtein" "B2RBV5" "MORF4 family associated protein 1 like 2 OS=Homo sapiens OX=9606 GN=MRFAP1L2 PE=1 SV=1" "0.024" "False" "1.496" "7" "1" "1" "1" "119" "13.4" "8.22" "1.89" "1" "other biological processes" "" "" "Pf15155" "" "" "MRFAP1L2" "B2RBV5" "" "" "0" "0" "1.141" "1.298" "1.103" "0.920" "1.149" "1.005" "0.989" "1.025" "0.772" "118.4" "135.1" "153.7" "130.6" "108.9" "136.1" "119.0" "117.1" "121.4" "91.5" "" "" "" "" "" "" "" "" "" "" "62.7" "74.9" "88.0" "60.2" "58.9" "75.7" "70.0" "63.9" "68.1" "91.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5704352961259904218" "False" "Medium" "IsMasterProtein" "Q14155" "Rho guanine nucleotide exchange factor 7 OS=Homo sapiens OX=9606 GN=ARHGEF7 PE=1 SV=2" "0.024" "False" "1.496" "1" "1" "1" "1" "803" "90.0" "7.09" "1.78" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00169, Pf00307, Pf00621, Pf07653, Pf16614, Pf16615" "8874" "ENSG00000102606" "ARHGEF7" "B1ALK6; B1ALK8; hsa:8874; Q14155; Q3LIA4; Q5W9H0; Q6P9G3; Q6PII2; Q86W63; Q8N3M1" "Integrin-mediated cell adhesion; CAMKK2 pathway; Regulation of actin cytoskeleton" "RHOV GTPase cycle; RHOU GTPase cycle; G alpha (12/13) signalling events; RAC1 GTPase cycle; NRAGE signals death through JNK; Ephrin signaling; RHOA GTPase cycle; CDC42 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle; EGFR downregulation" "14" "0" "0.990" "0.971" "1.255" "1.273" "1.097" "1.240" "0.779" "1.070" "3.505" "45.8" "45.3" "44.4" "57.4" "58.2" "50.2" "56.7" "35.6" "49.0" "160.4" "" "" "" "" "" "" "" "" "" "" "24.2" "25.1" "25.4" "26.4" "31.5" "27.9" "33.4" "19.4" "27.5" "160.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3220517271692211058" "False" "Medium" "IsMasterProtein" "Q9Y2X8" "Ubiquitin-conjugating enzyme E2 D4 OS=Homo sapiens OX=9606 GN=UBE2D4 PE=1 SV=1" "0.024" "False" "1.495" "5" "1" "1" "1" "147" "16.6" "7.37" "2.68" "1" "protein metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00179" "51619" "ENSG00000078967" "UBE2D4" "A4D1V0; hsa:51619; Q9Y2X8" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5620722506811584939" "False" "Medium" "IsMasterProtein" "Q96GG9" "DCN1-like protein 1 OS=Homo sapiens OX=9606 GN=DCUN1D1 PE=1 SV=1" "0.024" "False" "1.493" "3" "1" "1" "1" "259" "30.1" "5.34" "3.10" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03556, Pf14555" "54165" "ENSG00000043093" "DCUN1D1" "B2RB37; hsa:54165; Q7L3G9; Q8TEX7; Q96GG9; Q9H6M1; Q9HCT3" "" "Neddylation" "1" "0" "0.939" "1.080" "0.948" "1.086" "1.219" "0.948" "0.995" "1.128" "1.578" "159.7" "150.0" "172.5" "151.5" "173.6" "194.8" "151.4" "158.9" "180.3" "252.1" "" "" "" "" "" "" "" "" "" "" "84.6" "83.2" "98.8" "69.8" "93.9" "108.3" "89.1" "86.8" "101.1" "252.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8890760883318771042" "False" "Medium" "IsMasterProtein" "Q15653" "NF-kappa-B inhibitor beta OS=Homo sapiens OX=9606 GN=NFKBIB PE=1 SV=2" "0.025" "False" "1.491" "2" "1" "1" "1" "356" "37.7" "4.84" "2.23" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00023, Pf13637" "4793" "ENSG00000104825; ENSG00000282905" "NFKBIB" "A8K3F4; hsa:4793; Q15653; Q96BJ7" "IL-1 signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; IL-17 signaling pathway; TNF-alpha signaling pathway; Apoptosis; Novel intracellular components of RIG-I-like receptor pathway; Chemokine signaling pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Toll-like receptor signaling pathway" "Activation of NF-kappaB in B cells; RIP-mediated NFkB activation via ZBP1; TAK1-dependent IKK and NF-kappa-B activation ; TRAF6 mediated NF-kB activation" "16" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3635630023584853868" "False" "Medium" "IsMasterProtein" "Q9NQV8" "PR domain zinc finger protein 8 OS=Homo sapiens OX=9606 GN=PRDM8 PE=1 SV=3" "0.025" "False" "1.489" "1" "1" "1" "1" "689" "71.6" "7.84" "2.85" "1" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13894, Pf21549" "56978" "ENSG00000152784" "PRDM8" "A8K7X2; hsa:56978; Q6IQ36; Q9NQV8" "" "Regulation of CDH11 gene transcription" "1" "0" "0.922" "1.011" "1.014" "0.958" "0.982" "0.898" "0.892" "0.979" "0.915" "213.9" "197.3" "216.2" "217.0" "204.9" "210.0" "192.2" "190.8" "209.4" "195.8" "" "" "" "" "" "" "" "" "" "" "113.3" "109.4" "123.8" "99.9" "110.9" "116.8" "113.1" "104.1" "117.4" "195.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4022376780209334762" "False" "Medium" "IsMasterProtein" "Q96EM0" "Trans-3-hydroxy-L-proline dehydratase OS=Homo sapiens OX=9606 GN=L3HYPDH PE=1 SV=2" "0.025" "False" "1.488" "3" "1" "1" "1" "354" "38.1" "6.68" "2.56" "1" "" "" "other molecular function" "Pf05544" "112849" "ENSG00000126790" "L3HYPDH" "hsa:112849; Q96EM0; Q96LJ5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7476906646827946246" "False" "Medium" "IsMasterProtein" "Q13315" "Serine-protein kinase ATM OS=Homo sapiens OX=9606 GN=ATM PE=1 SV=4" "0.025" "False" "1.488" "0" "1" "1" "1" "3056" "350.5" "6.81" "2.18" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf11640" "472" "ENSG00000149311" "ATM" "B2RNX5; hsa:472; O15429; Q12758; Q13315; Q16551; Q93007; Q9NP02; Q9UCX7" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; TP53 network; Cell cycle; Homologous recombination; Glioblastoma signaling pathways; ATM signaling pathway; DDX1 as a regulatory component of the Drosha microprocessor; Ovarian infertility; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; ATM signaling in development and disease ; DNA IR-double strand breaks and cellular response via ATM; miRNA regulation of p53 pathway in prostate cancer; DNA IR-damage and cellular response via ATR; Breast cancer pathway; G1 to S cell cycle control; Joubert syndrome; Male infertility; DNA repair pathways, full network; Pleural mesothelioma; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome; Primary ovarian insufficiency; DNA damage response; DNA damage response (only ATM dependent)" "Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of HSF1-mediated heat shock response; Resolution of D-loop Structures through Holliday Junction Intermediates; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of TP53 Activity through Methylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Nonhomologous End-Joining (NHEJ); Sensing of DNA Double Strand Breaks; Pexophagy" "54" "0" "0.971" "0.976" "0.870" "0.947" "0.938" "0.891" "0.874" "0.886" "1.048" "137.3" "133.2" "134.0" "119.5" "130.0" "128.7" "122.3" "120.0" "121.6" "143.8" "" "" "" "" "" "" "" "" "" "" "72.7" "73.9" "76.7" "55.0" "70.3" "71.6" "72.0" "65.5" "68.2" "143.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1039714562309974451" "False" "Medium" "IsMasterProtein" "O14735" "CDP-diacylglycerol--inositol 3-phosphatidyltransferase OS=Homo sapiens OX=9606 GN=CDIPT PE=1 SV=1" "0.025" "False" "1.487" "3" "1" "1" "1" "213" "23.5" "8.03" "0.00" "1" "other metabolic processes" "plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf01066" "10423" "ENSG00000103502" "CDIPT" "B4DUV0; H3BTV1; hsa:10423; O14735; Q6FGU1; Q6ZN70" "Glycerolipids and glycerophospholipids; 16p11.2 proximal deletion syndrome" "Synthesis of PI" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4729149100999833326" "False" "Medium" "IsMasterProtein" "Q9NT62" "Ubiquitin-like-conjugating enzyme ATG3 OS=Homo sapiens OX=9606 GN=ATG3 PE=1 SV=1" "0.025" "False" "1.483" "2" "1" "1" "1" "314" "35.8" "4.74" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf03987" "64422" "ENSG00000144848" "ATG3" "hsa:64422; Q6PKC5; Q9H6L9; Q9NT62" "Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Clock-controlled autophagy in bone metabolism; ADHD and autism (ASD) linked metabolic pathways and SNP" "Macroautophagy" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5308082143838358470" "False" "Medium" "IsMasterProtein" "P42766" "Large ribosomal subunit protein uL29 OS=Homo sapiens OX=9606 GN=RPL35 PE=1 SV=2" "0.025" "False" "1.481" "6" "1" "1" "1" "123" "14.5" "11.05" "2.77" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00831" "11224" "ENSG00000136942" "RPL35" "A8K4V7; hsa:11224; P42766; Q4VBY5; Q5JTN5; Q6IBC7; Q96QJ7; Q9BYF4" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1487358643357756863" "False" "Medium" "IsMasterProtein" "P41214" "Eukaryotic translation initiation factor 2D OS=Homo sapiens OX=9606 GN=EIF2D PE=1 SV=3" "0.025" "False" "1.480" "1" "1" "1" "1" "584" "64.7" "7.65" "2.56" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01253, Pf17832" "1939" "ENSG00000143486" "EIF2D" "hsa:1939; P41214; Q5SY40; Q8IXV3; Q96DG3; Q96TG7; Q9NR27; Q9NSN0; Q9NV18; Q9NZ21" "" "" "0" "0" "1.206" "1.172" "1.164" "1.369" "1.339" "1.217" "0.936" "1.177" "5.367" "85.9" "103.6" "100.6" "100.0" "117.5" "115.0" "104.5" "80.4" "101.1" "461.0" "" "" "" "" "" "" "" "" "" "" "45.5" "57.4" "57.6" "46.1" "63.6" "64.0" "61.5" "43.9" "56.7" "461.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4316153505271773486" "False" "Medium" "IsMasterProtein" "P43354" "Nuclear receptor subfamily 4 group A member 2 OS=Homo sapiens OX=9606 GN=NR4A2 PE=1 SV=1" "0.025" "False" "1.477" "2" "1" "1" "1" "598" "66.5" "7.93" "0.00" "1" "cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105" "4929" "ENSG00000153234" "NR4A2" "hsa:4929; P43354; Q16311; Q53RZ2; Q6NXU0" "Nuclear receptors; Corticotropin-releasing hormone signaling pathway; Dopaminergic neurogenesis; VEGFA-VEGFR2 signaling; Cell lineage map for neuronal differentiation" "Nuclear Receptor transcription pathway; SUMOylation of intracellular receptors" "7" "0" "1.304" "1.367" "1.416" "1.233" "1.371" "1.194" "1.312" "1.213" "0.915" "60.2" "78.5" "82.3" "85.3" "74.2" "82.5" "71.9" "79.0" "73.0" "55.1" "" "" "" "" "" "" "" "" "" "" "31.9" "43.5" "47.1" "39.3" "40.2" "45.9" "42.3" "43.1" "41.0" "55.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1966383758785838168" "False" "Medium" "IsMasterProtein" "Q8TDS5" "Oxoeicosanoid receptor 1 OS=Homo sapiens OX=9606 GN=OXER1 PE=1 SV=2" "0.025" "False" "1.475" "2" "1" "1" "1" "384" "41.4" "9.57" "2.29" "1" "signal transduction" "plasma membrane;other membranes" "other molecular function" "Pf00001" "165140" "ENSG00000162881" "OXER1" "hsa:165140; Q86WP7; Q8NGW4; Q8TDS5" "" "G alpha (i) signalling events; Eicosanoid ligand-binding receptors" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5390707735378390925" "False" "Medium" "IsMasterProtein" "Q8IYB3" "Serine/arginine repetitive matrix protein 1 OS=Homo sapiens OX=9606 GN=SRRM1 PE=1 SV=2" "0.025" "False" "1.474" "1" "1" "1" "1" "904" "102.3" "11.84" "1.94" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf01480" "10250" "ENSG00000133226" "SRRM1" "hsa:10250; O60585; Q5VVN4; Q8IYB3" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "7" "0" "1.207" "1.112" "1.221" "1.215" "1.238" "1.379" "1.326" "1.225" "0.698" "35.7" "43.1" "39.7" "43.6" "43.4" "44.2" "49.3" "47.4" "43.7" "24.9" "" "" "" "" "" "" "" "" "" "" "18.9" "23.9" "22.7" "20.1" "23.5" "24.6" "29.0" "25.9" "24.5" "24.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5608760324881979441" "False" "Medium" "IsMasterProtein" "O14646" "Chromodomain-helicase-DNA-binding protein 1 OS=Homo sapiens OX=9606 GN=CHD1 PE=1 SV=2" "0.025" "False" "1.473" "1" "1" "1" "1" "1710" "196.6" "7.14" "2.61" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf13907, Pf18375" "1105" "ENSG00000153922" "CHD1" "hsa:1105; O14646; Q17RZ3" "" "Estrogen-dependent gene expression" "1" "0" "0.905" "0.940" "1.116" "0.892" "0.977" "0.935" "0.634" "0.658" "0.679" "293.6" "265.6" "275.9" "327.7" "261.8" "286.8" "274.5" "186.3" "193.3" "199.4" "" "" "" "" "" "" "" "" "" "" "155.5" "147.3" "158.0" "150.9" "141.6" "159.5" "161.6" "101.7" "108.4" "199.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3187595421119904315" "False" "Medium" "IsMasterProtein" "Q96K31" "Uncharacterized protein C8orf76 OS=Homo sapiens OX=9606 GN=C8orf76 PE=1 SV=1" "0.025" "False" "1.472" "2" "1" "1" "1" "380" "43.2" "5.43" "0.00" "1" "" "" "" "Pf17826" "84933" "ENSG00000189376" "C8orf76" "hsa:84933; Q53HC1; Q96K31" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2792434032950857374" "False" "Medium" "IsMasterProtein" "Q96HR3" "Mediator of RNA polymerase II transcription subunit 30 OS=Homo sapiens OX=9606 GN=MED30 PE=1 SV=1" "0.026" "False" "1.466" "4" "1" "1" "1" "178" "20.3" "8.27" "2.08" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11315" "90390" "ENSG00000164758" "MED30" "C6GKU9; hsa:90390; Q96HR3" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3663346498088535534" "False" "Medium" "IsMasterProtein" "P0CG31" "Putative zinc finger protein 286B OS=Homo sapiens OX=9606 GN=ZNF286B PE=5 SV=1" "0.026" "False" "1.465" "2" "1" "1" "1" "522" "59.5" "8.35" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "" "" "ZNF286B" "P0CG31" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1516422207583123109" "False" "Medium" "IsMasterProtein" "Q9NUD5" "Zinc finger CCHC domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZCCHC3 PE=1 SV=2" "0.025" "False" "1.461" "2" "1" "1" "1" "403" "43.5" "8.53" "2.22" "1" "stress response;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf00098" "85364" "ENSG00000247315" "ZCCHC3" "hsa:85364; Q3B7J3; Q6NT79; Q9NUD5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5269036548224773448" "False" "Medium" "IsMasterProtein" "Q6UXH1" "Protein disulfide isomerase CRELD2 OS=Homo sapiens OX=9606 GN=CRELD2 PE=1 SV=1" "0.025" "False" "1.461" "3" "1" "1" "1" "353" "38.2" "4.59" "0.00" "1" "" "non-structural extracellular;ER/Golgi" "other molecular function" "Pf07645" "79174" "ENSG00000184164" "CRELD2" "A5GZA2; A5GZA3; A5GZA4; A5GZA5; A5GZA6; hsa:79174; Q4W0V0; Q6UXH1; Q86UC0; Q9BU47" "" "" "0" "0" "0.822" "1.091" "1.021" "1.066" "0.969" "1.114" "1.026" "0.884" "0.635" "124.6" "102.5" "136.0" "127.2" "132.9" "120.8" "138.9" "127.8" "110.2" "79.2" "" "" "" "" "" "" "" "" "" "" "66.0" "56.8" "77.9" "58.6" "71.9" "67.2" "81.7" "69.8" "61.8" "79.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2600353075121762102" "False" "Medium" "IsMasterProtein" "A4D161" "Protein FAM221A OS=Homo sapiens OX=9606 GN=FAM221A PE=1 SV=1" "0.026" "False" "1.459" "3" "1" "1" "1" "298" "33.1" "6.74" "1.95" "1" "" "" "" "Pf14753" "340277" "ENSG00000188732" "FAM221A" "A4D161; hsa:340277; Q05CG4; Q4G0Q7; Q6P519" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4761760755167772661" "False" "Medium" "IsMasterProtein" "Q9GZR2" "RNA exonuclease 4 OS=Homo sapiens OX=9606 GN=REXO4 PE=1 SV=2" "0.026" "False" "1.458" "2" "1" "1" "1" "422" "46.6" "9.77" "2.52" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00929" "57109" "ENSG00000148300; ENSG00000280706" "REXO4" "B2RAT2; hsa:57109; Q5T8S4; Q5T8S5; Q5T8S6; Q9GZR2; Q9GZW3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7571054371893401161" "False" "Medium" "IsMasterProtein" "Q9Y4H2" "Insulin receptor substrate 2 OS=Homo sapiens OX=9606 GN=IRS2 PE=1 SV=2" "0.026" "False" "1.448" "1" "1" "1" "1" "1338" "137.2" "8.65" "1.67" "1" "cell cycle OR cell proliferation;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00169, Pf02174" "8660" "ENSG00000185950" "IRS2" "hsa:8660; Q96RR2; Q9BZG0; Q9Y4H2; Q9Y6I5" "Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Farnesoid X receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; Nonalcoholic fatty liver disease; Insulin signaling; FOXA2 pathway; Alzheimer's disease; EPO receptor signaling; Interferon type I signaling pathways" "PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); RAF/MAP kinase cascade; PI3K Cascade; Interleukin-7 signaling; PI3K/AKT activation; Growth hormone receptor signaling; Signaling by Leptin; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; SOS-mediated signalling; IRS activation; Signal attenuation" "38" "0" "1.431" "1.091" "1.154" "1.060" "1.300" "1.188" "0.782" "0.973" "2.245" "90.5" "129.5" "98.8" "104.4" "95.9" "117.7" "107.5" "70.7" "88.0" "203.2" "" "" "" "" "" "" "" "" "" "" "47.9" "71.8" "56.6" "48.1" "51.9" "65.5" "63.3" "38.6" "49.4" "203.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8470400305204825802" "False" "Medium" "IsMasterProtein" "Q9Y485" "DmX-like protein 1 OS=Homo sapiens OX=9606 GN=DMXL1 PE=1 SV=3" "0.026" "False" "1.448" "0" "1" "1" "1" "3027" "337.6" "6.34" "0.00" "1" "other biological processes" "other cell component" "" "Pf00400, Pf12234" "1657" "ENSG00000172869" "DMXL1" "hsa:1657; Q9Y485" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8301107896919222987" "False" "Medium" "IsMasterProtein" "Q8NCW6" "Polypeptide N-acetylgalactosaminyltransferase 11 OS=Homo sapiens OX=9606 GN=GALNT11 PE=1 SV=2" "0.026" "False" "1.444" "1" "1" "2" "1" "608" "68.9" "8.19" "3.84" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf00535, Pf00652" "63917" "ENSG00000178234" "GALNT11" "B3KWF4; hsa:63917; Q6PCD1; Q8NCW6; Q9H6C2; Q9H6Z5; Q9UDR8" "Ciliopathies" "O-linked glycosylation of mucins" "2" "0" "1.129" "0.978" "1.188" "1.331" "1.014" "1.207" "1.065" "1.019" "0.601" "280.6" "316.9" "274.4" "333.3" "373.5" "284.5" "338.6" "298.8" "285.8" "168.6" "" "" "" "" "" "" "" "" "" "" "148.6" "175.7" "157.1" "153.5" "202.1" "158.2" "199.3" "163.1" "160.3" "168.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7286073100971465543" "False" "Medium" "IsMasterProtein" "O95466" "Formin-like protein 1 OS=Homo sapiens OX=9606 GN=FMNL1 PE=1 SV=3" "0.026" "False" "1.441" "1" "1" "1" "1" "1100" "121.8" "5.72" "0.00" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "cytoskeletal activity;other molecular function" "Pf02181, Pf06367, Pf06371" "752" "ENSG00000184922" "FMNL1" "D2DGW2; hsa:752; O95466; Q6DKG5; Q6IBP3; Q86UH1; Q8N671; Q8TDH1; Q96H10" "" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHO GTPases Activate Formins" "3" "0" "1.076" "1.076" "1.184" "1.041" "1.059" "1.140" "0.694" "0.968" "2.984" "73.0" "78.6" "78.6" "86.5" "76.0" "77.4" "83.3" "50.7" "70.7" "218.0" "" "" "" "" "" "" "" "" "" "" "38.7" "43.6" "45.0" "39.8" "41.1" "43.0" "49.0" "27.7" "39.7" "218.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5331704730055142476" "False" "Medium" "IsMasterProtein" "Q8IVB5" "LIX1-like protein OS=Homo sapiens OX=9606 GN=LIX1L PE=1 SV=1" "0.027" "False" "1.440" "3" "1" "1" "1" "337" "36.5" "8.56" "2.21" "1" "cell organization and biogenesis;other metabolic processes" "other cell component" "" "Pf14954" "128077" "ENSG00000271601" "LIX1L" "hsa:128077; Q6AI36; Q8IVB5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7890982499762508055" "False" "Medium" "IsMasterProtein" "O75689" "Arf-GAP with dual PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ADAP1 PE=1 SV=2" "0.027" "False" "1.438" "2" "1" "1" "1" "374" "43.4" "8.97" "2.34" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf01412" "11033" "ENSG00000105963" "ADAP1" "A4D2Q2; B3KRZ4; B4DVA6; F6XZ68; H7C2Q4; hsa:11033; O75689" "" "Nuclear signaling by ERBB4" "1" "0" "1.058" "0.965" "0.990" "0.981" "0.831" "0.978" "0.824" "0.729" "1.070" "64.0" "67.7" "61.8" "63.4" "62.8" "53.2" "62.6" "52.8" "46.7" "68.5" "" "" "" "" "" "" "" "" "" "" "33.9" "37.5" "35.4" "29.2" "34.0" "29.6" "36.9" "28.8" "26.2" "68.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3244624518097785869" "False" "Medium" "IsMasterProtein" "Q676U5" "Autophagy-related protein 16-1 OS=Homo sapiens OX=9606 GN=ATG16L1 PE=1 SV=2" "0.027" "False" "1.434" "1" "1" "1" "1" "607" "68.2" "6.64" "1.97" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400, Pf08614" "55054" "ENSG00000085978; ENSG00000281089" "ATG16L1" "A3EXK9; A3EXL0; B6ZDH0; hsa:55054; Q676U5; Q6IPN1; Q6UXW4; Q6ZVZ5; Q8NCY2; Q96JV5; Q9H619" "Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; LDLRAD4 and what we know about it; Autophagy; Clock-controlled autophagy in bone metabolism; 8q11.23 (RB1CC1) copy number variation; ADHD and autism (ASD) linked metabolic pathways and SNP" "Macroautophagy" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5954226143684266914" "False" "Medium" "IsMasterProtein" "P10398" "Serine/threonine-protein kinase A-Raf OS=Homo sapiens OX=9606 GN=ARAF PE=1 SV=2" "0.027" "False" "1.433" "2" "1" "1" "1" "606" "67.5" "9.01" "2.30" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion" "kinase activity;other molecular function" "Pf00130, Pf02196, Pf07714" "369" "ENSG00000078061" "ARAF" "hsa:369; P07557; P10398; Q5H9B2; Q5H9B3" "Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; Common pathways underlying drug addiction; Bladder cancer; MAPK signaling pathway; Embryonic stem cell pluripotency pathways; Endometrial cancer; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Fragile X syndrome; Hepatitis B infection; Melanoma; EGFR tyrosine kinase inhibitor resistance; Alzheimer's disease; Acute myeloid leukemia; ErbB signaling pathway" "Signaling by BRAF and RAF1 fusions; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants" "33" "0" "1.030" "1.309" "1.007" "1.191" "0.941" "0.973" "0.709" "1.041" "7.584" "19.7" "20.3" "25.7" "19.8" "23.4" "18.5" "19.1" "13.9" "20.5" "149.1" "" "" "" "" "" "" "" "" "" "" "10.4" "11.2" "14.7" "9.1" "12.7" "10.3" "11.3" "7.6" "11.5" "149.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1866024987760357114" "False" "Medium" "IsMasterProtein" "Q9Y2A7" "Nck-associated protein 1 OS=Homo sapiens OX=9606 GN=NCKAP1 PE=1 SV=1" "0.027" "False" "1.433" "1" "1" "1" "1" "1128" "128.7" "6.62" "2.61" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "" "Pf09735" "10787" "ENSG00000061676" "NCKAP1" "hsa:10787; O60329; Q53QN5; Q53S94; Q53Y35; Q9Y2A7" "Exercise-induced circadian regulation; Regulation of actin cytoskeleton" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway" "9" "0" "1.133" "1.143" "1.202" "0.985" "1.069" "1.052" "0.953" "0.913" "1.289" "246.4" "279.2" "281.6" "296.1" "242.8" "263.4" "259.3" "234.8" "225.0" "317.8" "" "" "" "" "" "" "" "" "" "" "130.5" "154.8" "161.3" "136.4" "131.3" "146.5" "152.6" "128.2" "126.2" "317.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3396130811194437516" "False" "Medium" "IsMasterProtein" "O15254" "Peroxisomal acyl-coenzyme A oxidase 3 OS=Homo sapiens OX=9606 GN=ACOX3 PE=1 SV=2" "0.027" "False" "1.431" "1" "1" "1" "1" "700" "77.6" "7.25" "2.39" "1" "other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf01756, Pf02770" "8310" "ENSG00000087008" "ACOX3" "hsa:8310; O15254; Q96AJ8" "PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-3 / omega-6 fatty acid synthesis" "Peroxisomal protein import; Beta-oxidation of pristanoyl-CoA" "6" "0" "0.862" "1.114" "1.042" "0.886" "1.045" "0.938" "1.113" "1.152" "0.600" "77.1" "66.5" "85.9" "80.3" "68.3" "80.5" "72.3" "85.8" "88.7" "46.3" "" "" "" "" "" "" "" "" "" "" "40.8" "36.8" "49.2" "37.0" "36.9" "44.8" "42.5" "46.8" "49.8" "46.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5564485370032939878" "False" "Medium" "IsMasterProtein" "Q9UBV8" "Peflin OS=Homo sapiens OX=9606 GN=PEF1 PE=1 SV=1" "0.027" "False" "1.428" "4" "1" "2" "1" "284" "30.4" "6.54" "3.92" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf13405, Pf13499" "553115" "ENSG00000162517" "PEF1" "hsa:553115; Q9UBV8" "" "" "0" "0" "0.908" "0.970" "0.915" "0.979" "1.023" "1.040" "1.002" "0.955" "0.921" "210.7" "191.2" "204.4" "192.7" "206.2" "215.6" "219.2" "211.2" "201.1" "194.1" "" "" "" "" "" "" "" "" "" "" "111.6" "106.0" "117.0" "88.7" "111.6" "119.9" "129.0" "115.3" "112.8" "194.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7773792101669392702" "False" "Medium" "IsMasterProtein" "O94880" "PHD finger protein 14 OS=Homo sapiens OX=9606 GN=PHF14 PE=1 SV=3" "0.028" "False" "1.422" "1" "1" "1" "1" "948" "106.9" "5.34" "1.92" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00628, Pf13831, Pf13832" "9678" "ENSG00000106443" "PHF14" "A0A0U1RRH6; A7MCZ3; B4DI82; hsa:9678; O94880" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6924656061698190740" "False" "Medium" "IsMasterProtein" "Cont_Q2UVX4" "Complement C3 OS=Bos taurus OX=9913 GN=C3 PE=1 SV=2" "0.028" "True" "1.422" "1" "1" "1" "1" "1661" "187.1" "6.84" "1.76" "1" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf00207, Pf01759, Pf01821, Pf01835, Pf07677, Pf07678, Pf07703, Pf17789, Pf17790, Pf17791, Pf21308, Pf21406" "280677" "ENSBTAG00000017280" "C3" "bta:280677; Q2KIZ4; Q2UVX4" "Complement and coagulation cascades; Complement activation, classical pathway" "Neutrophil degranulation; Peptide ligand-binding receptors; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Alternative complement activation; Activation of C3 and C5" "11" "0" "0.673" "0.799" "1.269" "1.364" "0.897" "1.134" "0.908" "1.367" "0.735" "28.4" "19.1" "22.7" "36.0" "38.7" "25.5" "32.2" "25.8" "38.8" "20.9" "" "" "" "" "" "" "" "" "" "" "15.0" "10.6" "13.0" "16.6" "21.0" "14.2" "18.9" "14.1" "21.8" "20.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-372062034567143460" "False" "Medium" "IsMasterProtein" "Q9NQX4" "Unconventional myosin-Vc OS=Homo sapiens OX=9606 GN=MYO5C PE=1 SV=2" "0.028" "False" "1.419" "1" "1" "1" "1" "1742" "202.7" "7.71" "1.76" "1" "cell organization and biogenesis;transport" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf00612, Pf01843" "55930" "ENSG00000128833" "MYO5C" "hsa:55930; Q6P1W8; Q9NQX4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1699378345202944964" "False" "Medium" "IsMasterProtein" "Q96MX6" "Dynein axonemal assembly factor 10 OS=Homo sapiens OX=9606 GN=DNAAF10 PE=1 SV=1" "0.028" "False" "1.419" "2" "1" "1" "1" "357" "39.7" "8.09" "2.85" "1" "cell organization and biogenesis;other biological processes" "other cell component" "other molecular function" "Pf00400" "116143" "ENSG00000243667" "DNAAF10" "hsa:116143; Q96CR6; Q96MX6" "" "" "0" "0" "1.087" "1.097" "1.027" "1.194" "1.083" "1.232" "1.178" "1.178" "1.104" "267.9" "291.2" "293.9" "275.1" "319.8" "290.2" "330.1" "315.5" "315.6" "295.7" "" "" "" "" "" "" "" "" "" "" "141.9" "161.4" "168.3" "126.7" "173.0" "161.4" "194.3" "172.2" "177.1" "295.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6255156804242323935" "False" "Medium" "IsMasterProtein" "P58397" "A disintegrin and metalloproteinase with thrombospondin motifs 12 OS=Homo sapiens OX=9606 GN=ADAMTS12 PE=1 SV=2" "0.028" "False" "1.417" "0" "1" "1" "1" "1594" "177.6" "7.87" "2.23" "1" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix" "other molecular function" "Pf00090, Pf01421, Pf01562, Pf05986, Pf17771, Pf19030, Pf19236" "81792" "ENSG00000151388" "ADAMTS12" "A2RRN9; A5D6V6; hsa:81792; P58397; Q6UWL3" "" "Defective B3GALTL causes PpS; O-glycosylation of TSR domain-containing proteins" "2" "0" "1.138" "1.039" "1.077" "1.547" "0.916" "1.112" "0.996" "0.891" "0.727" "225.4" "256.4" "234.2" "242.7" "348.8" "206.4" "250.6" "224.5" "200.8" "163.7" "" "" "" "" "" "" "" "" "" "" "119.3" "142.2" "134.2" "111.8" "188.7" "114.8" "147.5" "122.5" "112.7" "163.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7937609985281019227" "False" "Medium" "IsMasterProtein" "Q96CM4" "Nucleoredoxin-like protein 1 OS=Homo sapiens OX=9606 GN=NXNL1 PE=1 SV=1" "0.028" "False" "1.414" "4" "1" "1" "1" "212" "23.9" "4.84" "2.87" "1" "other biological processes" "other cell component" "" "Pf13905" "115861" "ENSG00000171773" "NXNL1" "hsa:115861; Q0QD37; Q96CM4" "" "" "0" "0" "0.922" "0.953" "0.938" "0.997" "0.982" "0.905" "0.951" "1.051" "0.564" "167.4" "154.3" "159.5" "156.9" "166.9" "164.4" "151.4" "159.1" "175.9" "94.5" "" "" "" "" "" "" "" "" "" "" "88.6" "85.6" "91.4" "72.3" "90.3" "91.4" "89.1" "86.8" "98.7" "94.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-646999670011784093" "False" "Medium" "IsMasterProtein" "Q96S55" "ATPase WRNIP1 OS=Homo sapiens OX=9606 GN=WRNIP1 PE=1 SV=2" "0.028" "False" "1.413" "1" "1" "1" "1" "665" "72.1" "6.10" "0.00" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00004, Pf12002, Pf16193, Pf18279" "56897" "ENSG00000124535" "WRNIP1" "B2RDB0; hsa:56897; Q53EP6; Q59ET8; Q5W0E2; Q5W0E4; Q8WV26; Q96S55; Q9H681; Q9NRJ6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3202820232350468195" "False" "Medium" "IsMasterProtein" "Q8IYS2" "Uncharacterized protein KIAA2013 OS=Homo sapiens OX=9606 GN=KIAA2013 PE=1 SV=1" "0.028" "False" "1.412" "1" "1" "1" "1" "634" "69.1" "8.19" "0.00" "1" "" "" "" "Pf10222" "90231" "ENSG00000116685" "KIAA2013" "hsa:90231; Q5JXC1; Q8IVF8; Q8IYS2; Q8NDI7; Q9BSY1" "" "" "0" "0" "0.997" "0.982" "0.850" "1.009" "1.101" "0.932" "0.871" "0.936" "1.238" "83.1" "82.8" "81.6" "70.6" "83.8" "91.4" "77.5" "72.4" "77.7" "102.8" "" "" "" "" "" "" "" "" "" "" "44.0" "45.9" "46.7" "32.5" "45.3" "50.9" "45.6" "39.5" "43.6" "102.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7169750193396031031" "False" "Medium" "IsMasterProtein" "Q495C1" "Probable E3 SUMO-protein ligase RNF212 OS=Homo sapiens OX=9606 GN=RNF212 PE=2 SV=1" "0.028" "False" "1.412" "3" "1" "1" "1" "297" "33.3" "8.68" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes" "nucleus" "other molecular function" "Pf14634" "285498" "ENSG00000178222" "RNF212" "C9J8N0; hsa:285498; Q495C0; Q495C1; Q86W82; Q8IY99; Q8N8U7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2502404100025205194" "False" "Medium" "IsMasterProtein" "P27824" "Calnexin OS=Homo sapiens OX=9606 GN=CANX PE=1 SV=2" "0.028" "False" "1.412" "1" "1" "1" "1" "592" "67.5" "4.60" "2.73" "1" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00262" "821" "ENSG00000127022; ENSG00000283777" "CANX" "B2R5V8; B4DGP8; B4E2T8; D3DWQ3; D6R9K3; hsa:821; P27824" "15q11q13 copy number variation" "MHC class II antigen presentation; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Interleukin-35 Signalling; Interleukin-27 signaling; Assembly of Viral Components at the Budding Site; Maturation of spike protein; Calnexin/calreticulin cycle; Maturation of spike protein" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1549161421235899806" "False" "Medium" "IsMasterProtein" "Q96EH3" "Mitochondrial assembly of ribosomal large subunit protein 1 OS=Homo sapiens OX=9606 GN=MALSU1 PE=1 SV=1" "0.028" "False" "1.409" "3" "1" "1" "1" "234" "26.2" "5.49" "2.36" "1" "other biological processes" "cytosol;mitochondrion" "translation activity" "Pf02410" "115416" "ENSG00000156928" "MALSU1" "A4D154; hsa:115416; Q96EH3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5068245923404983933" "False" "Medium" "IsMasterProtein" "P53671" "LIM domain kinase 2 OS=Homo sapiens OX=9606 GN=LIMK2 PE=1 SV=1" "0.028" "False" "1.407" "1" "1" "1" "1" "638" "72.2" "7.20" "2.53" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00412, Pf00595, Pf07714" "3985" "ENSG00000182541" "LIMK2" "A8K6H5; hsa:3985; P53671; Q7KZ80; Q7L3H5; Q96E10; Q99464; Q9UFU0" "Androgen receptor signaling pathway; TGF-beta signaling pathway; EGF/EGFR signaling pathway" "EPHB-mediated forward signaling; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3970443704612931563" "False" "Medium" "IsMasterProtein" "P36578" "Large ribosomal subunit protein uL4 OS=Homo sapiens OX=9606 GN=RPL4 PE=1 SV=5" "0.028" "False" "1.407" "2" "1" "1" "1" "427" "47.7" "11.06" "1.69" "1" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00573, Pf14374" "6124" "ENSG00000174444" "RPL4" "A8K502; hsa:6124; P36578; P39029; Q4VBR0; Q969Z9" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4513402261466963400" "False" "Medium" "IsMasterProtein" "O75582" "Ribosomal protein S6 kinase alpha-5 OS=Homo sapiens OX=9606 GN=RPS6KA5 PE=1 SV=1" "0.028" "False" "1.400" "1" "1" "1" "1" "802" "89.8" "7.11" "2.59" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433" "9252" "ENSG00000100784" "RPS6KA5" "B7Z2Y5; hsa:9252; O75582; O95316; Q96AF7" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Interleukin-1 (IL-1) structural pathway; Bladder cancer; MAPK signaling pathway; ERK pathway in Huntington's disease; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; p38 MAPK signaling pathway; EGF/EGFR signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Insulin signaling; Pleural mesothelioma; Hippocampal synaptogenesis and neurogenesis; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways; Serotonin HTR1 group and FOS pathway; Serotonin receptor 4/6/7 and NR3C signaling" "Recycling pathway of L1; NCAM signaling for neurite out-growth; ERK/MAPK targets; CREB phosphorylation; CD209 (DC-SIGN) signaling" "22" "0" "0.934" "1.068" "0.796" "1.049" "0.811" "0.958" "0.942" "1.046" "1.484" "52.0" "48.6" "55.5" "41.4" "54.5" "42.1" "49.8" "48.9" "54.3" "77.1" "" "" "" "" "" "" "" "" "" "" "27.5" "26.9" "31.8" "19.0" "29.5" "23.4" "29.3" "26.7" "30.5" "77.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3678335116251458371" "False" "Medium" "IsMasterProtein" "P22670" "MHC class II regulatory factor RFX1 OS=Homo sapiens OX=9606 GN=RFX1 PE=1 SV=2" "0.028" "False" "1.400" "1" "1" "1" "1" "979" "104.7" "6.29" "0.00" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02257, Pf04589" "5989" "ENSG00000132005; ENSG00000288283" "RFX1" "hsa:5989; P22670" "Alstrom syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-888035968268434758" "False" "Medium" "IsMasterProtein" "Q9Y3B2" "Exosome complex component CSL4 OS=Homo sapiens OX=9606 GN=EXOSC1 PE=1 SV=1" "0.028" "False" "1.400" "4" "1" "1" "1" "195" "21.4" "8.24" "2.35" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity" "Pf10447, Pf14382" "51013" "ENSG00000171311" "EXOSC1" "B2R9B3; hsa:51013; Q5JTH3; Q9Y3B2" "" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2028658389890867927" "False" "Medium" "IsMasterProtein" "Q99708" "DNA endonuclease RBBP8 OS=Homo sapiens OX=9606 GN=RBBP8 PE=1 SV=2" "0.028" "False" "1.400" "1" "1" "1" "1" "897" "101.9" "6.30" "2.47" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08573, Pf10482" "5932" "ENSG00000101773" "RBBP8" "A6NKN2; A8K8W6; E7ETY1; hsa:5932; O75371; Q8NHQ3; Q99708" "ATM signaling in development and disease" "Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Resolution of D-loop Structures through Holliday Junction Intermediates; Transcriptional Regulation by E2F6; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through MMEJ (alt-NHEJ)" "18" "0" "1.197" "1.194" "1.177" "1.108" "1.021" "1.310" "1.302" "1.182" "1.418" "84.5" "101.1" "100.9" "99.5" "93.6" "86.2" "110.6" "110.0" "99.9" "119.8" "" "" "" "" "" "" "" "" "" "" "44.7" "56.1" "57.8" "45.8" "50.6" "48.0" "65.1" "60.1" "56.0" "119.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5054374183751915473" "False" "Medium" "IsMasterProtein" "Q13884" "Beta-1-syntrophin OS=Homo sapiens OX=9606 GN=SNTB1 PE=1 SV=3" "0.028" "False" "1.397" "1" "1" "1" "1" "538" "58.0" "8.63" "1.77" "1" "other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00595, Pf18012" "6641" "ENSG00000172164" "SNTB1" "A8K9E0; hsa:6641; O14912; Q13884; Q4KMG8" "IL-18 signaling pathway; 13q12.12 copy number variation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1500672588244887756" "False" "Medium" "IsMasterProtein" "P05089" "Arginase-1 OS=Homo sapiens OX=9606 GN=ARG1 PE=1 SV=2" "0.028" "False" "1.397" "3" "1" "1" "1" "322" "34.7" "7.21" "0.00" "1" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00491" "383" "ENSG00000118520" "ARG1" "A6NEA0; hsa:383; P05089; Q5JWT5; Q5JWT6; Q8TE72; Q9BS50" "Spinal cord injury; Amino acid metabolism; IL-18 signaling pathway" "Neutrophil degranulation; Urea cycle" "5" "0" "2.022" "0.916" "0.866" "0.927" "0.708" "1.113" "0.918" "1.384" "0.503" "59.6" "120.5" "54.6" "51.6" "55.2" "42.2" "66.3" "54.7" "82.5" "30.0" "" "" "" "" "" "" "" "" "" "" "31.6" "66.8" "31.3" "23.8" "29.9" "23.5" "39.0" "29.9" "46.3" "30.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7019173360477082359" "False" "Medium" "IsMasterProtein" "Q96QA5" "Gasdermin-A OS=Homo sapiens OX=9606 GN=GSDMA PE=1 SV=4" "0.028" "False" "1.395" "4" "1" "1" "1" "445" "49.3" "5.29" "0.00" "1" "stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "transporter activity;other molecular function" "Pf04598, Pf17708" "284110" "ENSG00000167914" "GSDMA" "hsa:284110; Q32MC5; Q86VE7; Q8N1M6; Q96QA5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5058994257240808720" "False" "Medium" "IsMasterProtein" "Q9ULR5" "Polyadenylate-binding protein-interacting protein 2B OS=Homo sapiens OX=9606 GN=PAIP2B PE=1 SV=2" "0.029" "False" "1.390" "7" "1" "1" "1" "123" "14.2" "4.17" "2.17" "1" "other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf07145" "400961" "ENSG00000124374" "PAIP2B" "hsa:400961; Q9ULR5" "" "" "0" "0" "1.311" "1.070" "1.214" "1.319" "1.094" "0.947" "1.102" "1.197" "1.252" "111.4" "146.0" "119.2" "135.2" "146.9" "121.9" "105.4" "122.8" "133.4" "139.4" "" "" "" "" "" "" "" "" "" "" "59.0" "80.9" "68.3" "62.3" "79.5" "67.8" "62.1" "67.0" "74.8" "139.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7485362868972298733" "False" "Medium" "IsMasterProtein" "P14174" "Macrophage migration inhibitory factor OS=Homo sapiens OX=9606 GN=MIF PE=1 SV=4" "0.029" "False" "1.387" "6" "1" "3" "1" "115" "12.5" "7.88" "7.61" "1" "cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01187" "4282" "ENSG00000240972; ENSG00000276701" "MIF" "A5Z1R8; B2R4S3; hsa:4282; P14174; Q2V4Y5; Q6FHV0" "Adipogenesis; Spinal cord injury; HDAC6 interactions in the central nervous system" "Neutrophil degranulation; Cell surface interactions at the vascular wall; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "6" "0" "0.930" "0.924" "0.909" "0.828" "0.822" "0.806" "0.880" "0.812" "0.416" "663.9" "617.3" "613.5" "603.4" "549.8" "545.5" "535.3" "584.5" "539.2" "276.4" "" "" "" "" "" "" "" "" "" "" "351.5" "342.3" "351.3" "277.9" "297.5" "303.4" "315.0" "319.0" "302.5" "276.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8309198551146026693" "False" "Medium" "IsMasterProtein" "O15226" "NF-kappa-B-repressing factor OS=Homo sapiens OX=9606 GN=NKRF PE=1 SV=2" "0.029" "False" "1.386" "1" "1" "1" "1" "690" "77.6" "8.79" "1.94" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01424, Pf01585" "55922" "ENSG00000186416" "NKRF" "G3V1N1; O15226; Q4VC41; Q9UJ91" "Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4903431523093654151" "False" "Medium" "IsMasterProtein" "A0A0B4J2F0" "Protein PIGBOS1 OS=Homo sapiens OX=9606 GN=PIGBOS1 PE=1 SV=1" "0.029" "False" "1.385" "19" "1" "1" "1" "54" "6.3" "8.50" "2.38" "1" "stress response;other biological processes" "other membranes;mitochondrion" "" "" "101928527" "ENSG00000225973" "PIGBOS1" "A0A0B4J2F0; hsa:101928527" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2389270481752188747" "False" "Medium" "IsMasterProtein" "Q92698" "DNA repair and recombination protein RAD54-like OS=Homo sapiens OX=9606 GN=RAD54L PE=1 SV=2" "0.030" "False" "1.380" "1" "1" "1" "1" "747" "84.3" "8.56" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271" "8438" "ENSG00000085999" "RAD54L" "hsa:8438; Q5TE31; Q6IUY3; Q92698" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9120276004969488072" "False" "Medium" "IsMasterProtein" "Q15080" "Neutrophil cytosol factor 4 OS=Homo sapiens OX=9606 GN=NCF4 PE=1 SV=2" "0.030" "False" "1.379" "3" "1" "1" "1" "339" "39.0" "6.83" "2.27" "1" "other metabolic processes;transport" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00564, Pf00787" "4689" "ENSG00000100365" "NCF4" "A8K4F9; hsa:4689; O60808; Q15080; Q86U56; Q9BU98; Q9NP45" "Microglia pathogen phagocytosis pathway; Urotensin-II-mediated signaling pathway; Genetic causes of porto-sinusoidal vascular disease" "RAC1 GTPase cycle; RAC3 GTPase cycle; RAC2 GTPase cycle; Detoxification of Reactive Oxygen Species; VEGFA-VEGFR2 Pathway; ROS and RNS production in phagocytes; Cross-presentation of particulate exogenous antigens (phagosomes); RHO GTPases Activate NADPH Oxidases" "11" "0" "0.735" "1.189" "1.123" "1.005" "1.005" "0.851" "0.232" "0.911" "9.040" "22.3" "16.4" "26.5" "25.0" "22.4" "22.4" "19.0" "5.2" "20.3" "201.4" "" "" "" "" "" "" "" "" "" "" "11.8" "9.1" "15.2" "11.5" "12.1" "12.4" "11.2" "2.8" "11.4" "201.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4670744058278942272" "False" "Medium" "IsMasterProtein" "Q9UN74" "Protocadherin alpha-4 OS=Homo sapiens OX=9606 GN=PCDHA4 PE=1 SV=1" "0.030" "False" "1.375" "1" "1" "1" "1" "947" "102.2" "5.08" "2.11" "1" "cell adhesion;developmental processes" "plasma membrane;other membranes" "other molecular function" "Pf00028, Pf08266, Pf15974" "56144" "ENSG00000204967; ENSG00000291652" "PCDHA4" "hsa:56144; O75285; Q2M253; Q9UN74" "GDNF signaling" "" "1" "0" "1.291" "1.332" "1.300" "1.137" "1.229" "1.296" "1.133" "1.307" "0.491" "39.9" "51.5" "53.2" "51.9" "45.4" "49.1" "51.8" "45.2" "52.2" "19.6" "" "" "" "" "" "" "" "" "" "" "21.1" "28.6" "30.5" "23.9" "24.6" "27.3" "30.5" "24.7" "29.3" "19.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6574533010040094760" "False" "Medium" "IsMasterProtein" "Q9NP62" "Chorion-specific transcription factor GCMa OS=Homo sapiens OX=9606 GN=GCM1 PE=1 SV=1" "0.030" "False" "1.371" "3" "1" "1" "1" "436" "49.2" "7.02" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03615" "8521" "ENSG00000137270" "GCM1" "hsa:8521; Q4VAQ7; Q5T0X0; Q99468; Q9NP62; Q9P1X3" "" "" "0" "0" "1.137" "1.010" "1.124" "1.365" "1.133" "1.025" "0.983" "1.016" "1.550" "48.0" "54.5" "48.5" "53.9" "65.5" "54.4" "49.2" "47.2" "48.7" "74.4" "" "" "" "" "" "" "" "" "" "" "25.4" "30.2" "27.8" "24.8" "35.4" "30.2" "28.9" "25.7" "27.3" "74.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6843403857140785601" "False" "Medium" "IsMasterProtein" "Q8NBL1" "Protein O-glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=POGLUT1 PE=1 SV=1" "0.030" "False" "1.370" "2" "1" "1" "1" "392" "46.2" "8.72" "2.75" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf05686" "56983" "ENSG00000163389" "POGLUT1" "B2RD13; hsa:56983; Q53GJ4; Q8N2T1; Q8NBL1" "" "Pre-NOTCH Processing in the Endoplasmic Reticulum" "1" "0" "1.156" "0.942" "1.089" "1.151" "1.018" "1.006" "0.904" "0.956" "1.095" "155.7" "180.0" "146.7" "169.6" "179.2" "158.6" "156.7" "140.7" "148.9" "170.5" "" "" "" "" "" "" "" "" "" "" "82.5" "99.8" "84.0" "78.1" "96.9" "88.2" "92.2" "76.8" "83.5" "170.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1908270249902800016" "False" "Medium" "IsMasterProtein" "P35573" "Glycogen debranching enzyme OS=Homo sapiens OX=9606 GN=AGL PE=1 SV=3" "0.029" "False" "1.368" "1" "1" "1" "1" "1532" "174.7" "6.76" "0.00" "1" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf06202, Pf14699, Pf14701, Pf14702" "178" "ENSG00000162688" "AGL" "A6NCX7; A6NEK2; D3DT51; hsa:178; P35573; P78354; P78544; Q59H92; Q6AZ90; Q9UF08" "Glycogen synthesis and degradation" "Neutrophil degranulation; Glycogen breakdown (glycogenolysis)" "3" "0" "0.844" "1.028" "0.979" "1.020" "0.965" "0.967" "1.057" "0.983" "0.729" "134.1" "113.1" "137.8" "131.2" "136.7" "129.4" "129.6" "141.7" "131.7" "97.8" "" "" "" "" "" "" "" "" "" "" "71.0" "62.7" "78.9" "60.4" "73.9" "72.0" "76.3" "77.4" "73.9" "97.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3978258356038081382" "False" "Medium" "IsMasterProtein" "Q13416" "Origin recognition complex subunit 2 OS=Homo sapiens OX=9606 GN=ORC2 PE=1 SV=2" "0.029" "False" "1.368" "1" "1" "1" "1" "577" "65.9" "6.51" "2.62" "1" "DNA metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf04084" "4999" "ENSG00000115942" "ORC2" "hsa:4999; Q13204; Q13416; Q53TX5" "Cell cycle; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication; CDC6 association with the ORC:origin complex" "10" "0" "1.193" "1.126" "1.207" "1.300" "1.217" "1.284" "1.000" "1.152" "3.184" "130.0" "155.2" "146.4" "156.9" "169.1" "158.2" "167.0" "130.0" "149.8" "414.0" "" "" "" "" "" "" "" "" "" "" "68.9" "86.0" "83.8" "72.3" "91.5" "88.0" "98.3" "71.0" "84.0" "414.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8641441660686703988" "False" "Medium" "IsMasterProtein" "O94868" "F-BAR and double SH3 domains protein 2 OS=Homo sapiens OX=9606 GN=FCHSD2 PE=1 SV=3" "0.029" "False" "1.365" "1" "1" "1" "1" "740" "84.2" "5.77" "2.51" "1" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00611, Pf14604" "9873" "ENSG00000137478" "FCHSD2" "B4DNI3; hsa:9873; O94868; Q7L8J9; Q8WVM2; Q96FV7; Q9UF77" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5723466212240730486" "False" "Medium" "IsMasterProtein" "Q13574" "Diacylglycerol kinase zeta OS=Homo sapiens OX=9606 GN=DGKZ PE=1 SV=4" "0.029" "False" "1.364" "1" "1" "1" "1" "928" "103.9" "8.05" "0.00" "1" "cell cycle OR cell proliferation;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00023, Pf00130, Pf00609, Pf00781" "8525" "ENSG00000149091" "DGKZ" "B7Z2M9; B7Z6M3; E9PPW4; F6UCU9; G3V0F6; hsa:8525; J3KNJ6; O00542; Q13574; Q6ZVG7; Q8IVW9" "Myometrial relaxation and contraction pathways; Leptin-insulin signaling overlap; Glycerolipids and glycerophospholipids; Modulators of TCR signaling and T cell activation" "Effects of PIP2 hydrolysis" "5" "0" "1.421" "1.051" "1.209" "1.031" "1.201" "1.302" "1.215" "1.028" "1.101" "27.5" "39.1" "28.9" "33.2" "28.3" "33.0" "35.8" "33.4" "28.3" "30.3" "" "" "" "" "" "" "" "" "" "" "14.6" "21.7" "16.5" "15.3" "15.3" "18.4" "21.1" "18.2" "15.9" "30.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7327599600572382898" "False" "Medium" "IsMasterProtein" "P08473" "Neprilysin OS=Homo sapiens OX=9606 GN=MME PE=1 SV=2" "0.029" "False" "1.364" "1" "1" "1" "1" "750" "85.5" "5.73" "2.20" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01431, Pf05649" "4311" "ENSG00000196549" "MME" "A8K6U6; D3DNJ9; hsa:4311; P08473; Q3MIX4" "Alzheimer's disease and miRNA effects; Primary focal segmental glomerulosclerosis (FSGS); Alzheimer's disease" "Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins; Physiological factors" "6" "0" "1.018" "1.051" "1.012" "1.124" "1.112" "1.018" "1.101" "1.076" "0.711" "140.1" "142.6" "147.2" "141.8" "157.4" "155.7" "142.6" "154.2" "150.7" "99.6" "" "" "" "" "" "" "" "" "" "" "74.2" "79.1" "84.3" "65.3" "85.2" "86.6" "83.9" "84.2" "84.5" "99.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3879446515340981987" "False" "Medium" "IsMasterProtein" "Q9C0I4" "Thrombospondin type-1 domain-containing protein 7B OS=Homo sapiens OX=9606 GN=THSD7B PE=1 SV=3" "0.029" "False" "1.362" "1" "1" "1" "1" "1606" "179.1" "7.59" "0.00" "1" "cell organization and biogenesis" "plasma membrane;other membranes" "" "Pf00090, Pf19028, Pf19030" "80731" "ENSG00000144229" "THSD7B" "E7EM75; hsa:80731; Q9C0I4" "" "Defective B3GALTL causes PpS; O-glycosylation of TSR domain-containing proteins" "2" "0" "1.011" "0.768" "1.279" "0.918" "0.862" "1.085" "0.843" "0.782" "0.592" "23.2" "23.4" "17.8" "29.6" "21.3" "20.0" "25.1" "19.5" "18.1" "13.7" "" "" "" "" "" "" "" "" "" "" "12.3" "13.0" "10.2" "13.6" "11.5" "11.1" "14.8" "10.7" "10.2" "13.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-215770254213962315" "False" "Medium" "IsMasterProtein" "Q12926" "ELAV-like protein 2 OS=Homo sapiens OX=9606 GN=ELAVL2 PE=1 SV=2" "0.029" "False" "1.360" "4" "1" "1" "1" "359" "39.5" "9.13" "0.00" "1" "other biological processes" "other cell component" "nucleic acid binding activity" "Pf00076" "1993" "ENSG00000107105" "ELAVL2" "D3DRK3; hsa:1993; Q12926; Q13235; Q59G15; Q8NEM4; Q9H1Q8" "" "" "0" "0" "0.989" "0.919" "0.973" "1.078" "0.937" "0.957" "0.860" "1.018" "0.884" "71.7" "70.9" "65.9" "69.7" "77.3" "67.2" "68.6" "61.6" "72.9" "63.3" "" "" "" "" "" "" "" "" "" "" "38.0" "39.3" "37.7" "32.1" "41.8" "37.4" "40.4" "33.6" "40.9" "63.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1731274812714259147" "False" "Medium" "IsMasterProtein" "Q9NYJ8" "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 OS=Homo sapiens OX=9606 GN=TAB2 PE=1 SV=1" "0.029" "False" "1.358" "1" "1" "1" "1" "693" "76.4" "8.54" "2.55" "1" "stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02845" "23118" "ENSG00000055208" "TAB2" "B2RCC4; E1P5A0; hsa:23118; O94838; Q6I9W8; Q76N06; Q9NYJ8; Q9UFP7" "IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; MAPK signaling pathway; TLR4 signaling and tolerance; Exercise-induced circadian regulation; miRNA role in immune response in sepsis; Measles virus infection; Hepatitis B infection; Toll-like receptor signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Nuclear signaling by ERBB4; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TAK1-dependent IKK and NF-kappa-B activation ; TNFR1-induced NF-kappa-B signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway" "27" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4698111209888211937" "False" "Medium" "IsMasterProtein" "Q99732" "Lipopolysaccharide-induced tumor necrosis factor-alpha factor OS=Homo sapiens OX=9606 GN=LITAF PE=1 SV=2" "0.030" "False" "1.349" "4" "1" "1" "1" "161" "17.1" "6.44" "2.12" "1" "other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf10601" "9516" "ENSG00000189067" "LITAF" "D3DUG1; G5E9K0; hsa:9516; Q05DW0; Q99732; Q9C0L6" "Intracellular trafficking proteins involved in CMT neuropathy" "" "1" "0" "0.894" "1.149" "1.002" "1.067" "1.134" "0.917" "1.046" "0.969" "0.845" "71.6" "64.0" "82.3" "71.8" "76.4" "81.3" "65.7" "75.0" "69.4" "60.6" "" "" "" "" "" "" "" "" "" "" "37.9" "35.5" "47.1" "33.1" "41.4" "45.2" "38.7" "40.9" "38.9" "60.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3491083928038066110" "False" "Medium" "IsMasterProtein" "Q9NZM5" "Ribosome biogenesis protein NOP53 OS=Homo sapiens OX=9606 GN=NOP53 PE=1 SV=2" "0.030" "False" "1.348" "1" "1" "1" "1" "478" "54.4" "10.32" "2.02" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07767" "29997" "ENSG00000105373" "NOP53" "hsa:29997; Q9BTC6; Q9HAX6; Q9NPP1; Q9NPR4; Q9NZM5; Q9UFI2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4456055578033296242" "False" "Medium" "IsMasterProtein" "Q8TF72" "Protein Shroom3 OS=Homo sapiens OX=9606 GN=SHROOM3 PE=1 SV=2" "0.031" "False" "1.348" "0" "1" "1" "1" "1996" "216.7" "7.80" "2.51" "1" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00595, Pf08687, Pf08688" "57619" "ENSG00000138771" "SHROOM3" "hsa:57619; Q5QTQ3; Q6ZRW3; Q8TF72; Q96IR9; Q9P247" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5814198643835656164" "False" "Medium" "IsMasterProtein" "O60711" "Leupaxin OS=Homo sapiens OX=9606 GN=LPXN PE=1 SV=1" "0.031" "False" "1.345" "3" "1" "1" "1" "386" "43.3" "6.01" "0.00" "1" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00412" "9404" "ENSG00000110031" "LPXN" "B2R8B4; B4DV71; hsa:9404; O60711; Q53FW6; Q6FI07" "" "" "0" "0" "1.670" "1.298" "2.360" "1.323" "1.389" "2.480" "2.314" "1.647" "2.781" "15.9" "26.5" "20.6" "37.4" "21.0" "22.0" "39.3" "36.7" "26.1" "44.1" "" "" "" "" "" "" "" "" "" "" "8.4" "14.7" "11.8" "17.2" "11.4" "12.2" "23.1" "20.0" "14.7" "44.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3246576723643333795" "False" "Medium" "IsMasterProtein" "Q8N668" "COMM domain-containing protein 1 OS=Homo sapiens OX=9606 GN=COMMD1 PE=1 SV=1" "0.031" "False" "1.342" "4" "1" "1" "1" "190" "21.2" "6.20" "0.00" "1" "DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07258, Pf17221" "150684" "ENSG00000173163" "COMMD1" "B4DFQ4; hsa:150684; Q8N668; Q96GS0" "Copper homeostasis; 1p36 copy number variation syndrome" "Neddylation" "3" "0" "0.973" "0.886" "1.013" "1.001" "1.124" "0.884" "0.760" "0.910" "1.268" "94.0" "91.5" "83.2" "95.2" "94.1" "105.7" "83.1" "71.4" "85.5" "119.2" "" "" "" "" "" "" "" "" "" "" "49.8" "50.7" "47.7" "43.9" "50.9" "58.8" "48.9" "39.0" "48.0" "119.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5055980742492995321" "False" "Medium" "IsMasterProtein" "Q8TD91" "Melanoma-associated antigen C3 OS=Homo sapiens OX=9606 GN=MAGEC3 PE=1 SV=1" "0.031" "False" "1.341" "3" "1" "1" "1" "643" "71.9" "4.87" "1.65" "1" "other biological processes" "nucleus" "" "" "139081" "ENSG00000165509" "MAGEC3" "hsa:139081; Q3SYA7; Q5JZ43; Q8TD91; Q9BZ80" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4254593612476960216" "False" "Medium" "IsMasterProtein" "Q9BTZ2" "Dehydrogenase/reductase SDR family member 4 OS=Homo sapiens OX=9606 GN=DHRS4 PE=1 SV=3" "0.031" "False" "1.340" "3" "1" "1" "1" "278" "29.5" "8.56" "1.75" "1" "other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf13561" "10901" "ENSG00000157326; ENSG00000284807" "DHRS4" "B2RB10; B7WNS9; D3YTB8; E2QRL8; hsa:10901; O95162; Q20CR0; Q2LC19; Q2LE81; Q58IU4; Q6E0Y1; Q6UWU3; Q71UQ6; Q8TD03; Q9BTZ2; Q9H3N5; Q9NV08" "" "Peroxisomal protein import; RA biosynthesis pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4354971542348250461" "False" "Medium" "IsMasterProtein" "Q96BW9" "Phosphatidate cytidylyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=TAMM41 PE=1 SV=2" "0.031" "False" "1.334" "3" "1" "1" "1" "452" "51.0" "7.94" "0.00" "1" "other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf09139" "132001" "ENSG00000144559" "TAMM41" "B4DIY7; C9J2U4; hsa:132001; Q96BW9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8492559823843858039" "False" "Medium" "IsMasterProtein" "Q6ZW49" "PAX-interacting protein 1 OS=Homo sapiens OX=9606 GN=PAXIP1 PE=1 SV=2" "0.031" "False" "1.333" "1" "1" "2" "1" "1069" "121.3" "6.70" "2.13" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf00533, Pf12738, Pf16589" "22976" "ENSG00000157212" "PAXIP1" "hsa:22976; O15404; Q6N099; Q6ZW49; Q6ZWH9; Q7Z315; Q86UN0; Q8N4P9; Q96HP2" "16p11.2 proximal deletion syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Kleefstra syndrome" "Nonhomologous End-Joining (NHEJ); Activation of anterior HOX genes in hindbrain development during early embryogenesis; Formation of WDR5-containing histone-modifying complexes" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4353551603118957972" "False" "Medium" "IsMasterProtein" "P34949" "Mannose-6-phosphate isomerase OS=Homo sapiens OX=9606 GN=MPI PE=1 SV=2" "0.031" "False" "1.332" "2" "1" "1" "1" "423" "46.6" "5.95" "1.72" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf01238, Pf20511, Pf20512" "4351" "ENSG00000178802" "MPI" "A8K8K9; hsa:4351; P34949; Q96AB0" "N-glycan biosynthesis" "Synthesis of GDP-mannose; Defective MPI causes MPI-CDG" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1465431971745530473" "False" "Medium" "IsMasterProtein" "Q3KRA9" "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 OS=Homo sapiens OX=9606 GN=ALKBH6 PE=1 SV=2" "0.031" "False" "1.332" "3" "1" "1" "1" "238" "26.5" "8.78" "2.41" "1" "" "nucleus;other cell component" "other molecular function" "Pf13532" "84964" "ENSG00000239382" "ALKBH6" "A5LGM8; A6NLP1; A8MU96; hsa:84964; Q3KRA9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2594177095458516104" "False" "Medium" "IsMasterProtein" "P24386" "Rab proteins geranylgeranyltransferase component A 1 OS=Homo sapiens OX=9606 GN=CHM PE=1 SV=3" "0.031" "False" "1.330" "1" "1" "2" "1" "653" "73.4" "4.75" "2.12" "1" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "1121" "ENSG00000188419" "CHM" "A1L4D2; hsa:1121; O43732; P24386" "" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "3" "0" "1.474" "0.823" "1.301" "0.826" "0.881" "1.039" "0.730" "0.900" "0.626" "51.2" "75.5" "42.2" "66.6" "42.3" "45.1" "53.2" "37.4" "46.1" "32.0" "" "" "" "" "" "" "" "" "" "" "27.1" "41.8" "24.1" "30.7" "22.9" "25.1" "31.3" "20.4" "25.9" "32.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2830448209821531490" "False" "Medium" "IsMasterProtein" "Q9GZS3" "Superkiller complex protein 8 OS=Homo sapiens OX=9606 GN=SKIC8 PE=1 SV=1" "0.032" "False" "1.329" "2" "1" "1" "1" "305" "33.6" "5.47" "2.71" "1" "cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00400" "80349" "ENSG00000140395" "SKIC8" "D3DW84; hsa:80349; Q6IA22; Q7Z4X4; Q9GZS3" "" "E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; mRNA decay by 3' to 5' exoribonuclease" "5" "0" "1.046" "0.967" "1.011" "1.059" "1.042" "1.072" "0.980" "1.088" "0.602" "241.5" "252.5" "233.5" "244.2" "255.6" "251.7" "258.8" "236.7" "262.7" "145.5" "" "" "" "" "" "" "" "" "" "" "127.9" "140.0" "133.7" "112.4" "138.3" "140.0" "152.3" "129.2" "147.4" "145.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5479596295726178059" "False" "Medium" "IsMasterProtein" "P98160" "Basement membrane-specific heparan sulfate proteoglycan core protein OS=Homo sapiens OX=9606 GN=HSPG2 PE=1 SV=4" "0.032" "False" "1.328" "0" "1" "1" "1" "4391" "468.5" "6.51" "2.77" "1" "other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "signal transduction activity or receptor binding;extracellular structural activity;other molecular function" "Pf00008, Pf00052, Pf00053, Pf00054, Pf00057, Pf02210, Pf07679, Pf13895, Pf13927" "3339" "ENSG00000142798" "HSPG2" "hsa:3339; P98160; Q16287; Q5SZI3; Q9H3V5" "Hepatitis B infection; Comprehensive IL-17A signaling" "Degradation of the extracellular matrix; ECM proteoglycans; Non-integrin membrane-ECM interactions; Laminin interactions; RSV-host interactions; Amyloid fiber formation; Integrin cell surface interactions; Respiratory syncytial virus (RSV) attachment and entry; A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Attachment and Entry; Retinoid metabolism and transport" "20" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8567537084386512250" "False" "Medium" "IsMasterProtein" "P20933" "N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase OS=Homo sapiens OX=9606 GN=AGA PE=1 SV=2" "0.032" "False" "1.328" "2" "1" "1" "1" "346" "37.2" "6.28" "2.06" "1" "protein metabolism;other metabolic processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01112" "175" "ENSG00000038002" "AGA" "B2R7H2; D3DP47; hsa:175; P20933; Q4W5Q2; Q6FHN6; Q9UCK6; Q9UCK7; Q9UCK8" "" "Neutrophil degranulation" "1" "0" "1.028" "0.951" "0.978" "0.968" "0.926" "0.937" "1.135" "0.959" "0.582" "97.5" "100.3" "92.8" "95.4" "94.4" "90.3" "91.4" "110.7" "93.5" "56.8" "" "" "" "" "" "" "" "" "" "" "51.6" "55.6" "53.1" "44.0" "51.1" "50.2" "53.8" "60.4" "52.4" "56.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2974578878725693910" "False" "Medium" "IsMasterProtein" "P45984" "Mitogen-activated protein kinase 9 OS=Homo sapiens OX=9606 GN=MAPK9 PE=1 SV=2" "0.032" "False" "1.325" "2" "1" "1" "1" "424" "48.1" "5.63" "0.00" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5601" "ENSG00000050748" "MAPK9" "A8K0S3; B5BU66; B5M0B4; D3DWQ8; D3DWQ9; hsa:5601; P45984; Q15708; Q15710; Q15711; Q8N5C5" "IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling pathway; Interleukin-1 (IL-1) structural pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; Canonical and non-canonical TGF-B signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; BMP signaling in eyelid development; Wnt signaling pathway and pluripotency; Splicing factor NOVA regulated synaptic proteins; Wnt signaling in kidney disease; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Regulatory circuits of the STAT3 signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; TGF-beta receptor signaling in skeletal dysplasias; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; CCL18 signaling pathway; Familial partial lipodystrophy; Alzheimer's disease; GDNF signaling; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; 5q35 copy number variation; 13q12.12 copy number variation; TGF-beta receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Estrogen signaling pathway; Toll-like receptor signaling pathway" "Signaling by ALK fusions and activated point mutants; FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Activation of the AP-1 family of transcription factors" "66" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2472661976687595252" "False" "Medium" "IsMasterProtein" "Q5VTT5" "Myomesin-3 OS=Homo sapiens OX=9606 GN=MYOM3 PE=1 SV=1" "0.032" "False" "1.324" "1" "1" "1" "1" "1437" "162.1" "6.23" "0.00" "1" "" "cytoskeleton" "other molecular function" "Pf00041, Pf07679" "127294" "ENSG00000142661" "MYOM3" "A6NF75; hsa:127294; Q5VTT5; Q5VTT6; Q6AWC0; Q6AWC1; Q6NXF9; Q6ZRG7; Q7Z3G9; Q8NA11; Q96C54" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4573891914704923062" "False" "Medium" "IsMasterProtein" "Q9BTE1" "Dynactin subunit 5 OS=Homo sapiens OX=9606 GN=DCTN5 PE=1 SV=1" "0.032" "False" "1.324" "4" "1" "1" "1" "182" "20.1" "8.02" "2.11" "1" "developmental processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf21711" "84516" "ENSG00000166847" "DCTN5" "A8K9X8; H3BN51; H3BQA4; hsa:84516; Q9BTE1" "Vasopressin-regulated water reabsorption" "COPI-mediated anterograde transport; MHC class II antigen presentation; COPI-independent Golgi-to-ER retrograde traffic; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" "5" "0" "1.203" "1.074" "1.003" "1.031" "1.211" "1.289" "1.401" "1.072" "0.843" "48.4" "58.2" "51.9" "48.5" "49.9" "58.6" "62.4" "67.7" "51.8" "40.8" "" "" "" "" "" "" "" "" "" "" "25.6" "32.3" "29.7" "22.3" "27.0" "32.6" "36.7" "37.0" "29.1" "40.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1877789849069093785" "False" "Medium" "IsMasterProtein" "Q9UIW2" "Plexin-A1 OS=Homo sapiens OX=9606 GN=PLXNA1 PE=1 SV=3" "0.032" "False" "1.320" "0" "1" "1" "1" "1896" "210.9" "6.92" "2.34" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf01403, Pf01437, Pf01833, Pf08337, Pf17960, Pf18020, Pf20170" "5361" "ENSG00000114554" "PLXNA1" "hsa:5361; Q9UIW2" "" "Sema3A PAK dependent Axon repulsion; RHOD GTPase cycle; RND1 GTPase cycle; CRMPs in Sema3A signaling; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Other semaphorin interactions" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6897785543843873721" "False" "Medium" "IsMasterProtein" "Q7Z5J4" "Retinoic acid-induced protein 1 OS=Homo sapiens OX=9606 GN=RAI1 PE=1 SV=2" "0.032" "False" "1.320" "1" "1" "1" "1" "1906" "203.2" "8.79" "0.00" "1" "developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13771" "10743" "ENSG00000108557" "RAI1" "hsa:10743; Q7Z5J4; Q8N3B4; Q8ND08; Q8WU64; Q96JK5; Q9H1C1; Q9H1C2; Q9UF69" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Heme signaling; Circadian Clock" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4152312257978312183" "False" "Medium" "IsMasterProtein" "P48050" "Inward rectifier potassium channel 4 OS=Homo sapiens OX=9606 GN=KCNJ4 PE=1 SV=1" "0.032" "False" "1.317" "2" "1" "1" "1" "445" "49.5" "6.21" "0.00" "1" "transport;other biological processes" "plasma membrane;other membranes" "transporter activity;other molecular function" "Pf01007, Pf17655" "3761" "ENSG00000168135" "KCNJ4" "hsa:3761; P48050; Q14D44" "" "Phase 4 - resting membrane potential; Activation of G protein gated Potassium channels; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Classical Kir channels" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "921315881662704994" "False" "Medium" "IsMasterProtein" "O15040" "Tectonin beta-propeller repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=TECPR2 PE=1 SV=4" "0.033" "False" "1.311" "0" "1" "1" "1" "1411" "153.8" "5.55" "2.47" "1" "other metabolic processes;transport" "other cell component" "" "Pf06462, Pf19193" "9895" "ENSG00000196663" "TECPR2" "A5PKY3; A6NFY9; A7E2X3; H0YMM9; hsa:9895; O15040; Q9UEG6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1227550599144237947" "False" "Medium" "IsMasterProtein" "Q6SPF0" "Sterile alpha motif domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SAMD1 PE=1 SV=1" "0.033" "False" "1.310" "1" "1" "1" "1" "538" "56.0" "7.58" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cell component" "other molecular function" "Pf00536, Pf21524" "90378" "ENSG00000288488" "SAMD1" "hsa:90378; Q6P0R3; Q6PIS7; Q6SPF0; Q96IM4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-274346279625731140" "False" "Medium" "IsMasterProtein" "O00471" "Exocyst complex component 5 OS=Homo sapiens OX=9606 GN=EXOC5 PE=1 SV=1" "0.033" "False" "1.304" "1" "1" "1" "1" "708" "81.8" "6.71" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;other cell component" "other molecular function" "Pf07393, Pf20667" "10640" "ENSG00000070367" "EXOC5" "B2R6C5; hsa:10640; O00471; Q8IW24" "Ciliary landscape" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "4" "0" "1.207" "1.183" "1.762" "1.514" "1.155" "1.265" "1.237" "1.147" "2.070" "31.7" "38.3" "37.5" "55.9" "48.0" "36.6" "40.1" "39.2" "36.4" "65.6" "" "" "" "" "" "" "" "" "" "" "16.8" "21.2" "21.5" "25.7" "26.0" "20.4" "23.6" "21.4" "20.4" "65.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4887773767884950166" "False" "Medium" "IsMasterProtein" "Q68DK7" "Male-specific lethal 1 homolog OS=Homo sapiens OX=9606 GN=MSL1 PE=1 SV=3" "0.034" "False" "1.301" "1" "1" "1" "1" "614" "67.1" "8.92" "2.31" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf15275, Pf16801" "339287" "ENSG00000188895" "MSL1" "hsa:339287; Q0VF46; Q68DK7; Q69Z03" "" "HATs acetylate histones" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5052566407640781283" "False" "Medium" "IsMasterProtein" "Q96M94" "Kelch-like protein 15 OS=Homo sapiens OX=9606 GN=KLHL15 PE=1 SV=2" "0.033" "False" "1.299" "1" "1" "1" "1" "604" "69.7" "6.40" "2.07" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00651, Pf01344, Pf07707, Pf13964" "80311" "ENSG00000174010" "KLHL15" "hsa:80311; Q32MN3; Q8NDA3; Q96BM6; Q96M94; Q9C0I6" "" "" "0" "0" "0.944" "1.091" "0.887" "1.151" "1.062" "0.947" "1.000" "0.974" "0.842" "91.5" "86.4" "99.8" "81.2" "105.3" "97.1" "86.6" "91.5" "89.1" "77.0" "" "" "" "" "" "" "" "" "" "" "48.5" "47.9" "57.2" "37.4" "57.0" "54.0" "51.0" "50.0" "50.0" "77.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7158809287201110390" "False" "Medium" "IsMasterProtein" "P49069" "Guided entry of tail-anchored proteins factor CAMLG OS=Homo sapiens OX=9606 GN=CAMLG PE=1 SV=1" "0.033" "False" "1.299" "2" "1" "1" "1" "296" "32.9" "8.05" "1.66" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf14963" "819" "ENSG00000164615" "CAMLG" "A1L3Y3; hsa:819; P49069" "" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2977729941869003476" "False" "Medium" "IsMasterProtein" "Q6P4F7" "Rho GTPase-activating protein 11A OS=Homo sapiens OX=9606 GN=ARHGAP11A PE=1 SV=2" "0.035" "False" "1.294" "1" "1" "1" "1" "1023" "113.8" "9.07" "0.00" "1" "signal transduction;other biological processes" "cytosol;nucleus" "enzyme regulator activity" "Pf00620" "9824" "ENSG00000198826; ENSG00000275568" "ARHGAP11A" "B4DZN9; hsa:9824; Q6P4F7; Q6PI96; Q9Y3S6" "" "RHOA GTPase cycle" "1" "0" "1.159" "1.062" "1.153" "1.076" "1.234" "1.168" "0.839" "0.891" "1.754" "40.9" "47.5" "43.5" "47.2" "44.1" "50.5" "47.8" "34.4" "36.5" "71.8" "" "" "" "" "" "" "" "" "" "" "21.7" "26.3" "24.9" "21.7" "23.8" "28.1" "28.1" "18.8" "20.5" "71.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2174289831199594781" "False" "Medium" "IsMasterProtein" "Q2KHR3" "Glutamine and serine-rich protein 1 OS=Homo sapiens OX=9606 GN=QSER1 PE=1 SV=3" "0.035" "False" "1.291" "1" "1" "1" "1" "1735" "189.9" "7.08" "0.00" "1" "" "other cell component" "" "Pf13926" "79832" "" "QSER1" "hsa:79832; Q2KHR3; Q6ZU30; Q6ZUR5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8695808721246024709" "False" "Medium" "IsMasterProtein" "O75838" "Calcium and integrin-binding family member 2 OS=Homo sapiens OX=9606 GN=CIB2 PE=1 SV=1" "0.035" "False" "1.283" "6" "1" "1" "1" "187" "21.6" "4.61" "0.00" "1" "other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "signal transduction activity or receptor binding;other molecular function" "" "10518" "ENSG00000136425" "CIB2" "B4DDF0; H0YM71; hsa:10518; O75838; Q05BT6" "" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7407118807577494974" "False" "Medium" "IsMasterProtein" "Q5VST6" "Alpha/beta hydrolase domain-containing protein 17B OS=Homo sapiens OX=9606 GN=ABHD17B PE=1 SV=1" "0.035" "False" "1.281" "3" "1" "1" "1" "288" "32.2" "6.29" "0.00" "1" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00326" "51104" "ENSG00000107362" "ABHD17B" "A8KAJ5; hsa:51104; Q5VST6; Q5VST7; Q86YB6; Q8IY03; Q9Y377" "" "RAS processing" "1" "0" "1.038" "1.143" "1.206" "1.041" "0.804" "1.147" "0.842" "0.914" "0.970" "23.1" "24.0" "26.4" "27.8" "24.0" "18.5" "26.5" "19.4" "21.1" "22.4" "" "" "" "" "" "" "" "" "" "" "12.2" "13.3" "15.1" "12.8" "13.0" "10.3" "15.6" "10.6" "11.8" "22.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6355678057945092611" "False" "Medium" "IsMasterProtein" "P42695" "Condensin-2 complex subunit D3 OS=Homo sapiens OX=9606 GN=NCAPD3 PE=1 SV=2" "0.039" "False" "1.276" "0" "1" "1" "1" "1498" "168.8" "7.50" "2.19" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12717" "23310" "ENSG00000151503" "NCAPD3" "A6NFS2; hsa:23310; P42695; Q4KMQ9" "" "Condensation of Prophase Chromosomes" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8000039368752286519" "False" "Medium" "IsMasterProtein" "P47901" "Vasopressin V1b receptor OS=Homo sapiens OX=9606 GN=AVPR1B PE=1 SV=1" "0.039" "False" "1.275" "2" "1" "1" "1" "424" "46.9" "8.92" "0.00" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00001" "553" "ENSG00000198049" "AVPR1B" "B0M0J6; hsa:553; P47901; Q5TZ00" "Peptide GPCRs; GPCRs, class A rhodopsin-like; Soluble ACE2-mediated cell entry of SARS-CoV-2" "G alpha (q) signalling events; Vasopressin-like receptors; Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)" "6" "0" "1.397" "1.182" "1.315" "1.220" "1.141" "1.359" "1.046" "0.956" "0.799" "34.9" "48.8" "41.3" "45.9" "42.6" "39.8" "47.4" "36.5" "33.4" "27.9" "" "" "" "" "" "" "" "" "" "" "18.5" "27.0" "23.6" "21.2" "23.1" "22.2" "27.9" "19.9" "18.7" "27.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2488299377452803712" "False" "Medium" "IsMasterProtein" "Q8N9T8" "Protein KRI1 homolog OS=Homo sapiens OX=9606 GN=KRI1 PE=1 SV=3" "0.039" "False" "1.274" "1" "1" "1" "1" "703" "82.5" "5.14" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf05178, Pf12936" "65095" "ENSG00000129347" "KRI1" "hsa:65095; Q2M1R5; Q2M1R7; Q7L5J7; Q8N9T8; Q96G92; Q9BU50; Q9H6I1; Q9H978" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8396834273640286125" "False" "Medium" "IsMasterProtein" "O75695" "Protein XRP2 OS=Homo sapiens OX=9606 GN=RP2 PE=1 SV=4" "0.039" "False" "1.273" "2" "1" "1" "1" "350" "39.6" "5.12" "2.57" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf07986" "6102" "ENSG00000102218" "RP2" "hsa:6102; O75695; Q86XJ7; Q9NU67" "Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "Trafficking of myristoylated proteins to the cilium" "4" "0" "1.063" "0.887" "0.939" "0.845" "0.900" "0.767" "0.984" "0.891" "0.582" "123.4" "131.2" "109.4" "115.9" "104.3" "111.1" "94.6" "121.4" "110.0" "71.8" "" "" "" "" "" "" "" "" "" "" "65.3" "72.8" "62.7" "53.4" "56.4" "61.8" "55.7" "66.3" "61.7" "71.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "697873925504819237" "False" "Medium" "IsMasterProtein" "P50053" "Ketohexokinase OS=Homo sapiens OX=9606 GN=KHK PE=1 SV=2" "0.039" "False" "1.271" "2" "1" "1" "1" "298" "32.5" "6.32" "2.89" "1" "other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00294" "3795" "ENSG00000138030" "KHK" "hsa:3795; P50053; Q6IBK2; Q99532; Q9BRJ3; Q9UMN1" "Disorders of fructose metabolism; Polyol pathway" "Fructose catabolism; Essential fructosuria" "4" "0" "0.914" "0.913" "1.158" "1.013" "0.991" "1.066" "0.988" "0.901" "0.685" "180.2" "164.8" "164.5" "208.8" "182.5" "178.6" "192.2" "178.1" "162.4" "123.4" "" "" "" "" "" "" "" "" "" "" "95.4" "91.3" "94.2" "96.1" "98.7" "99.3" "113.1" "97.2" "91.1" "123.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8425175822669482526" "False" "Medium" "IsMasterProtein" "Q9NRY5" "Protein FAM114A2 OS=Homo sapiens OX=9606 GN=FAM114A2 PE=1 SV=4" "0.039" "False" "1.268" "1" "1" "1" "1" "505" "55.4" "4.88" "2.70" "1" "" "" "other molecular function" "Pf05334" "10827" "ENSG00000055147" "FAM114A2" "B2R8D8; hsa:10827; Q9H7E0; Q9NRY5" "" "Signaling by BRAF and RAF1 fusions" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1837950048141820937" "False" "Medium" "IsMasterProtein" "Q9C0D4" "Zinc finger protein 518B OS=Homo sapiens OX=9606 GN=ZNF518B PE=1 SV=2" "0.039" "False" "1.267" "1" "1" "1" "1" "1074" "119.5" "9.45" "0.00" "1" "cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "85460" "ENSG00000178163" "ZNF518B" "hsa:85460; Q96LN8; Q9C0D4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7354713298349425858" "False" "Medium" "IsMasterProtein" "Q8N1T3" "Unconventional myosin-Ih OS=Homo sapiens OX=9606 GN=MYO1H PE=1 SV=2" "0.040" "False" "1.260" "1" "1" "1" "1" "1032" "119.0" "9.09" "2.27" "1" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf06017" "" "" "MYO1H" "F5H3C6; Q8N1T3" "" "" "0" "0" "0.981" "0.953" "1.040" "1.001" "1.059" "1.162" "1.088" "0.971" "0.649" "257.1" "252.2" "245.1" "267.5" "257.4" "272.3" "298.6" "279.7" "249.7" "166.7" "" "" "" "" "" "" "" "" "" "" "136.1" "139.8" "140.3" "123.2" "139.3" "151.5" "175.8" "152.7" "140.1" "166.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3084200639085863850" "False" "Medium" "IsMasterProtein" "O14497" "AT-rich interactive domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ARID1A PE=1 SV=3" "0.040" "False" "1.259" "0" "1" "1" "1" "2285" "241.9" "6.70" "1.98" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01388, Pf12031" "8289" "ENSG00000117713" "ARID1A" "D3DPL1; hsa:8289; O14497; Q53FK9; Q5T0W1; Q5T0W2; Q5T0W3; Q8NFD6; Q96T89; Q9BY33; Q9HBJ5; Q9UPZ1" "Androgen receptor network in prostate cancer; Pathways affected in adenoid cystic carcinoma; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "7" "0" "1.006" "0.988" "0.846" "1.007" "1.026" "0.984" "1.045" "0.993" "0.528" "236.0" "237.3" "233.1" "199.6" "237.6" "242.2" "232.2" "246.6" "234.5" "124.5" "" "" "" "" "" "" "" "" "" "" "125.0" "131.6" "133.5" "91.9" "128.5" "134.7" "136.6" "134.6" "131.5" "124.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8571260626068012330" "False" "Medium" "IsMasterProtein" "Q9NXK8" "F-box/LRR-repeat protein 12 OS=Homo sapiens OX=9606 GN=FBXL12 PE=1 SV=1" "0.041" "False" "1.258" "3" "1" "1" "1" "326" "37.0" "8.79" "2.24" "1" "protein metabolism;other metabolic processes" "cytosol;other cell component" "" "Pf12937" "54850" "ENSG00000127452" "FBXL12" "B3KSJ8; hsa:54850; Q9H5K4; Q9NXK8" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "1.044" "1.034" "0.986" "1.162" "1.182" "1.133" "0.909" "0.994" "0.977" "78.3" "81.7" "80.9" "77.2" "91.0" "92.5" "88.7" "71.1" "77.8" "76.5" "" "" "" "" "" "" "" "" "" "" "41.4" "45.3" "46.3" "35.6" "49.2" "51.5" "52.2" "38.8" "43.6" "76.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-749299575230837699" "False" "Medium" "IsMasterProtein" "Q9HAT2" "Sialate O-acetylesterase OS=Homo sapiens OX=9606 GN=SIAE PE=1 SV=1" "0.041" "False" "1.254" "2" "1" "1" "1" "523" "58.3" "7.33" "1.95" "1" "other metabolic processes;other biological processes" "other cytoplasmic organelle" "other molecular function" "Pf03629" "54414" "ENSG00000110013" "SIAE" "B3KPB0; hsa:54414; Q8IUT9; Q9HAT2; Q9HAU7; Q9NT71" "" "" "0" "0" "1.043" "0.865" "1.102" "1.045" "0.861" "1.124" "0.842" "1.068" "0.772" "60.6" "63.2" "52.4" "66.8" "63.3" "52.1" "68.1" "51.0" "64.7" "46.7" "" "" "" "" "" "" "" "" "" "" "32.1" "35.0" "30.0" "30.7" "34.2" "29.0" "40.1" "27.8" "36.3" "46.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3944939482947776682" "False" "Medium" "IsMasterProtein" "P00480" "Ornithine transcarbamylase, mitochondrial OS=Homo sapiens OX=9606 GN=OTC PE=1 SV=3" "0.041" "False" "1.252" "2" "1" "1" "1" "354" "39.9" "8.63" "0.00" "1" "other metabolic processes;developmental processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00185, Pf02729" "5009" "ENSG00000036473" "OTC" "A8K9P2; D3DWB0; hsa:5009; P00480; Q3KNR1; Q6B0I1; Q9NYJ5" "Amino acid metabolism" "Mitochondrial protein import; Urea cycle" "3" "0" "0.947" "0.862" "1.240" "1.027" "1.023" "1.166" "0.599" "0.894" "0.844" "44.8" "42.5" "38.6" "55.6" "46.0" "45.9" "52.2" "26.8" "40.1" "37.8" "" "" "" "" "" "" "" "" "" "" "23.7" "23.5" "22.1" "25.6" "24.9" "25.5" "30.8" "14.6" "22.5" "37.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5232175681869918932" "False" "Medium" "IsMasterProtein" "Q14678" "KN motif and ankyrin repeat domain-containing protein 1 OS=Homo sapiens OX=9606 GN=KANK1 PE=1 SV=3" "0.041" "False" "1.247" "1" "1" "1" "1" "1352" "147.2" "5.30" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00023, Pf12075" "23189" "ENSG00000107104" "KANK1" "A2A2W8; D3DRH3; hsa:23189; Q14678; Q5W0W0; Q8IY65; Q8WX74" "VEGFA-VEGFR2 signaling" "Estrogen-dependent gene expression; Signaling by membrane-tethered fusions of PDGFRA or PDGFRB" "3" "0" "1.171" "1.234" "1.226" "1.254" "1.022" "1.250" "1.271" "1.091" "2.130" "47.4" "55.4" "58.5" "58.1" "59.4" "48.4" "59.2" "60.2" "51.7" "100.9" "" "" "" "" "" "" "" "" "" "" "25.1" "30.7" "33.5" "26.7" "32.1" "26.9" "34.9" "32.9" "29.0" "100.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3273725157349986493" "False" "Medium" "IsMasterProtein" "Q99698" "Lysosomal-trafficking regulator OS=Homo sapiens OX=9606 GN=LYST PE=1 SV=3" "0.042" "False" "1.244" "0" "1" "1" "1" "3801" "428.9" "6.61" "2.62" "1" "cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;cytosol;cytoskeleton" "other molecular function" "Pf00400, Pf02138, Pf14844" "1130" "ENSG00000143669" "LYST" "hsa:1130; O43274; Q5T2U9; Q96TD7; Q96TD8; Q99698; Q99709; Q9H133" "" "" "0" "0" "0.966" "0.988" "1.236" "1.142" "1.228" "1.157" "1.256" "1.120" "1.140" "100.3" "96.9" "99.1" "124.0" "114.6" "123.2" "116.1" "126.0" "112.3" "114.4" "" "" "" "" "" "" "" "" "" "" "53.1" "53.8" "56.8" "57.1" "62.0" "68.5" "68.3" "68.8" "63.0" "114.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6486195661784381210" "False" "Medium" "IsMasterProtein" "Q96QU1" "Protocadherin-15 OS=Homo sapiens OX=9606 GN=PCDH15 PE=1 SV=2" "0.042" "False" "1.244" "1" "1" "1" "1" "1955" "215.9" "5.07" "2.08" "1" "cell adhesion;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf00028, Pf18432" "65217" "ENSG00000150275" "PCDH15" "A6NL19; C6ZEF5; C6ZEF6; C6ZEF7; hsa:65217; Q5VY38; Q5VY39; Q6TRH8; Q8NDB9; Q96QT8; Q96QU1" "" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "2" "0" "1.102" "1.122" "0.983" "1.021" "1.014" "1.009" "1.061" "1.055" "0.558" "245.4" "270.4" "275.3" "241.2" "250.7" "249.0" "247.7" "260.3" "258.9" "137.0" "" "" "" "" "" "" "" "" "" "" "130.0" "149.9" "157.7" "111.1" "135.6" "138.5" "145.8" "142.1" "145.2" "137.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4426217636715391666" "False" "Medium" "IsMasterProtein" "Q9H9F9" "Actin-related protein 5 OS=Homo sapiens OX=9606 GN=ACTR5 PE=1 SV=2" "0.042" "False" "1.244" "1" "1" "1" "1" "607" "68.3" "5.27" "2.31" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf00022" "79913" "ENSG00000101442" "ACTR5" "hsa:79913; Q86WF7; Q8IUY5; Q8N724; Q9BRN0; Q9BVB7; Q9H9F9" "" "UCH proteinases; DNA Damage Recognition in GG-NER" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4333754145708475207" "False" "Medium" "IsMasterProtein" "Q9UKT8" "F-box/WD repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=FBXW2 PE=1 SV=2" "0.042" "False" "1.242" "2" "1" "1" "1" "454" "51.5" "6.58" "1.67" "1" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00400, Pf00646" "26190" "ENSG00000119402" "FBXW2" "B3KRL8; hsa:26190; Q4VXH2; Q7Z4V6; Q8WV51; Q9HA09; Q9UKA3; Q9UKT8" "Wnt signaling pathway and pluripotency" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Association of TriC/CCT with target proteins during biosynthesis" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6827826663467104318" "False" "Medium" "IsMasterProtein" "Q9UK41" "Vacuolar protein sorting-associated protein 28 homolog OS=Homo sapiens OX=9606 GN=VPS28 PE=1 SV=1" "0.043" "False" "1.237" "4" "1" "1" "1" "221" "25.4" "5.54" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03997" "51160" "ENSG00000160948; ENSG00000285339" "VPS28" "hsa:51160; Q86VK0; Q9UK41" "7q11.23 copy number variation syndrome" "Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5142259406840293622" "False" "Medium" "IsMasterProtein" "Q14738" "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform OS=Homo sapiens OX=9606 GN=PPP2R5D PE=1 SV=1" "0.043" "False" "1.236" "2" "1" "1" "1" "602" "69.9" "8.13" "0.00" "1" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01603" "5528" "ENSG00000112640" "PPP2R5D" "A8K3I9; B5BUA6; hsa:5528; O00494; O00696; Q14738; Q15171; Q5TC39" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling; DARPP-32 events; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "33" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2523415922773781630" "False" "Medium" "IsMasterProtein" "Q9Y3C1" "Nucleolar protein 16 OS=Homo sapiens OX=9606 GN=NOP16 PE=1 SV=2" "0.043" "False" "1.235" "4" "1" "1" "1" "178" "21.2" "9.94" "1.95" "1" "other biological processes" "nucleus;other cell component" "" "Pf09420" "51491" "ENSG00000048162" "NOP16" "B4DV13; D6RGD3; hsa:51491; Q05D05; Q6IAI6; Q6PIM0; Q8IXL5; Q9Y3C1" "5q35 copy number variation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4375562830836446683" "False" "Medium" "IsMasterProtein" "Q15386" "Ubiquitin-protein ligase E3C OS=Homo sapiens OX=9606 GN=UBE3C PE=1 SV=3" "0.043" "False" "1.234" "1" "1" "1" "1" "1083" "123.8" "6.71" "1.70" "1" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00632" "9690" "ENSG00000009335" "UBE3C" "A4D235; A6NCP3; hsa:9690; Q15386; Q8TC15; Q96CR4; Q9UDU3" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-749856808040687854" "False" "Medium" "IsMasterProtein" "Q8WTS6" "Histone-lysine N-methyltransferase SETD7 OS=Homo sapiens OX=9606 GN=SETD7 PE=1 SV=1" "0.044" "False" "1.233" "2" "1" "1" "1" "366" "40.7" "4.63" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00856, Pf02493" "80854" "ENSG00000145391" "SETD7" "B5WWL3; hsa:80854; Q0VAH3; Q4W5A9; Q8WTS6; Q9C0E6" "Histone modifications" "PKMTs methylate histone lysines" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3079825360121275387" "False" "Medium" "IsMasterProtein" "Q5SNV9" "Uncharacterized protein C1orf167 OS=Homo sapiens OX=9606 GN=C1orf167 PE=2 SV=3" "0.044" "False" "1.226" "1" "1" "1" "1" "1449" "160.4" "10.89" "0.00" "1" "" "" "" "Pf15736" "" "" "C1orf167" "A0A8I5KXP5; hsa:284498" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5573084200900719321" "False" "Medium" "IsMasterProtein" "Q9Y5V0" "Zinc finger protein 706 OS=Homo sapiens OX=9606 GN=ZNF706 PE=1 SV=1" "0.045" "False" "1.222" "8" "1" "1" "1" "76" "8.5" "10.01" "2.06" "1" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf04419, Pf12874" "51123" "ENSG00000120963" "ZNF706" "A8K362; hsa:51123; Q9Y5V0" "" "Generic Transcription Pathway" "1" "0" "0.834" "0.948" "0.829" "0.848" "0.897" "0.833" "0.791" "0.893" "0.331" "216.9" "181.0" "205.7" "179.9" "184.0" "194.6" "180.6" "171.5" "193.6" "71.7" "" "" "" "" "" "" "" "" "" "" "114.9" "100.3" "117.8" "82.9" "99.5" "108.2" "106.3" "93.6" "108.6" "71.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7195707004351779863" "False" "Medium" "IsMasterProtein" "Q5VT98" "PRAME family member 20 OS=Homo sapiens OX=9606 GN=PRAMEF20 PE=3 SV=2" "0.045" "False" "1.222" "3" "1" "1" "1" "475" "54.7" "8.06" "0.00" "1" "other biological processes" "other cell component" "" "" "645425" "ENSG00000204478" "PRAMEF20" "hsa:645425; Q5VT98" "" "" "0" "0" "1.101" "1.206" "1.276" "1.442" "1.086" "1.736" "1.386" "1.579" "1.547" "41.9" "46.2" "50.6" "53.5" "60.5" "45.6" "72.8" "58.1" "66.2" "64.9" "" "" "" "" "" "" "" "" "" "" "22.2" "25.6" "29.0" "24.7" "32.7" "25.3" "42.9" "31.7" "37.2" "64.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4845049006096107700" "False" "Medium" "IsMasterProtein" "Q8TCT7" "Signal peptide peptidase-like 2B OS=Homo sapiens OX=9606 GN=SPPL2B PE=1 SV=2" "0.045" "False" "1.221" "1" "1" "1" "1" "592" "64.6" "8.32" "2.09" "1" "protein metabolism;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf02225, Pf04258" "56928" "ENSG00000005206" "SPPL2B" "D6W609; hsa:56928; O60365; Q567S3; Q8IUH9; Q8TCT7; Q9BUY6; Q9H3M4; Q9NPN2; Q9P1Z6" "" "Regulation of TNFR1 signaling" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2027123753413932420" "False" "Medium" "IsMasterProtein" "Q8NBN7" "Retinol dehydrogenase 13 OS=Homo sapiens OX=9606 GN=RDH13 PE=1 SV=2" "0.045" "False" "1.221" "2" "1" "1" "1" "331" "35.9" "8.10" "1.83" "1" "other metabolic processes;developmental processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00106" "112724" "ENSG00000160439; ENSG00000273944; ENSG00000274418; ENSG00000274504; ENSG00000275474; ENSG00000276341; ENSG00000276684; ENSG00000276826; ENSG00000278149; ENSG00000278284" "RDH13" "Q6UX79; Q8NBN7; Q96G88" "" "RA biosynthesis pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2857975298597403350" "False" "Medium" "IsMasterProtein" "Q96N67" "Dedicator of cytokinesis protein 7 OS=Homo sapiens OX=9606 GN=DOCK7 PE=1 SV=4" "0.045" "False" "1.218" "0" "1" "1" "1" "2140" "242.4" "6.80" "2.70" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "85440" "ENSG00000116641" "DOCK7" "hsa:85440; Q00M63; Q2PPY7; Q45RE8; Q45RE9; Q5T1B9; Q5T1C0; Q6ZV32; Q8TB82; Q96N67; Q96NG6; Q96NI0; Q9C092" "" "CDC42 GTPase cycle; RAC1 GTPase cycle; Factors involved in megakaryocyte development and platelet production; MET activates RAP1 and RAC1" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4352192512000317053" "False" "Medium" "IsMasterProtein" "Q9Y619" "Mitochondrial ornithine transporter 1 OS=Homo sapiens OX=9606 GN=SLC25A15 PE=1 SV=1" "0.045" "False" "1.217" "4" "1" "1" "1" "301" "32.7" "9.13" "0.00" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf00153" "10166" "ENSG00000102743" "SLC25A15" "hsa:10166; Q5VZD8; Q9HC45; Q9Y619" "" "Urea cycle" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "742235004239548424" "False" "Medium" "IsMasterProtein" "Q6ICL3" "Transport and Golgi organization protein 2 homolog OS=Homo sapiens OX=9606 GN=TANGO2 PE=1 SV=1" "0.045" "False" "1.217" "3" "1" "1" "1" "276" "30.9" "5.17" "2.44" "1" "cell organization and biogenesis;transport" "cytosol;mitochondrion;ER/Golgi;other cell component" "" "Pf05742" "128989" "ENSG00000183597" "TANGO2" "A8MUE9; B7WNV6; B7Z583; B7Z730; D3DX23; hsa:128989; Q6ICL3; Q8IW05; Q8NAL0; Q8TCS0; Q96M16" "22q11.2 copy number variation syndrome" "" "1" "0" "0.971" "0.814" "1.087" "1.119" "1.110" "1.070" "0.971" "0.954" "0.667" "94.7" "92.0" "77.1" "102.9" "106.0" "105.1" "101.3" "91.9" "90.4" "63.2" "" "" "" "" "" "" "" "" "" "" "50.2" "51.0" "44.1" "47.4" "57.4" "58.5" "59.6" "50.2" "50.7" "63.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" ""