Protein Entry Name Protein names Gene Names Organism Gene Ontology (biological process) Gene Ontology (cellular component) Gene Ontology (molecular function) Peptide ID Score Mass stdev (Da) MH+ (Da) 1_C_serum 1_E_serum 1_LM_serum 1_P_serum 1_SC_serum A0A8C0TLV1 A0A8C0TLV1_CANLF "1,4-alpha-glucan branching enzyme (EC 2.4.1.18)" GBE1 Canis lupus familiaris (Dog) (Canis familiaris) glycogen biosynthetic process [GO:0005978] "1,4-alpha-glucan branching enzyme activity [GO:0003844]; cation binding [GO:0043169]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]" REEMYR 1.5 0.250514887 884.5833237 13.52166 14.28932 14.66888 12.47036 15.02752 A0A8I3RXD7 A0A8I3RXD7_CANLF 1-alkyl-2-acetylglycerophosphocholine esterase (EC 3.1.1.47) PLA2G7 Canis lupus familiaris (Dog) (Canis familiaris) lipid oxidation [GO:0034440]; low-density lipoprotein particle remodeling [GO:0034374]; phosphatidylcholine catabolic process [GO:0034638]; plasma lipoprotein particle oxidation [GO:0034441]; platelet activating factor catabolic process [GO:0062234]; positive regulation of monocyte chemotaxis [GO:0090026] high-density lipoprotein particle [GO:0034364]; low-density lipoprotein particle [GO:0034362] 1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; calcium-independent phospholipase A2 activity [GO:0047499]; phospholipid binding [GO:0005543] SSPSLPR 13.68000031 1.22E-13 743.5072859 15.17538 14.85397 8.421651 10.06633 18.40546 A0A8C0NZ13 A0A8C0NZ13_CANLF "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase (EC 3.1.4.11)" Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042] calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0004435] RPATVV 2.180000067 1.23E-13 642.618839 17.16756 17.66283 16.36193 17.8873 0 A0A8C0Z363 A0A8C0Z363_CANLF "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma (EC 3.1.4.11)" PLCG1 Canis lupus familiaris (Dog) (Canis familiaris) calcium-mediated signaling [GO:0019722]; cell migration [GO:0016477]; cellular response to epidermal growth factor stimulus [GO:0071364]; epidermal growth factor receptor signaling pathway [GO:0007173]; in utero embryonic development [GO:0001701]; modulation of chemical synaptic transmission [GO:0050804]; phospholipid catabolic process [GO:0009395]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; T cell receptor signaling pathway [GO:0050852] cell-cell junction [GO:0005911]; COP9 signalosome [GO:0008180]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; ruffle membrane [GO:0032587]; Schaffer collateral - CA1 synapse [GO:0098685] calcium ion binding [GO:0005509]; glutamate receptor binding [GO:0035254]; neurotrophin TRKA receptor binding [GO:0005168]; phosphatidylinositol phospholipase C activity [GO:0004435]; receptor tyrosine kinase binding [GO:0030971] ALFDYKAQR 1.159999967 0.314362308 1112.13632 0 16.07819 8.377172 13.52258 14.26587 A0A8C0PFY2 A0A8C0PFY2_CANLF 1-phosphatidylinositol 4-kinase (EC 2.7.1.67) PI4KA Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310] kinase activity [GO:0016301] GGAKPLR 8.699999809 0.469980395 698.0683808 15.09098 16.58053 14.9992 0 0 A0A8C0TID3 A0A8C0TID3_CANLF "2-oxoglutarate dehydrogenase complex component E1 (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase)" OGDH Canis lupus familiaris (Dog) (Canis familiaris) 2-oxoglutarate metabolic process [GO:0006103]; cerebellar cortex development [GO:0021695]; hippocampus development [GO:0021766]; olfactory bulb mitral cell layer development [GO:0061034]; pyramidal neuron development [GO:0021860]; striatum development [GO:0021756]; succinyl-CoA metabolic process [GO:0006104]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028]; thalamus development [GO:0021794]; tricarboxylic acid cycle [GO:0006099] mitochondrion [GO:0005739]; nucleus [GO:0005634]; oxoglutarate dehydrogenase complex [GO:0045252] oxoglutarate dehydrogenase (NAD+) activity [GO:0034602]; oxoglutarate dehydrogenase (succinyl-transferring) activity [GO:0004591]; thiamine pyrophosphate binding [GO:0030976] DEKILHIK 15.14999962 0.294941587 996.2005642 18.28952 14.03078 15.3527 15.41857 15.57149 A0A8C0PEY0 A0A8C0PEY0_CANLF 3CxxC-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VDKDLLPNSLK 6.480000019 0 1240.920802 11.59187 13.05156 10.26533 12.61969 16.36727 A0A8C0M330 A0A8C0M330_CANLF 4'-phosphopantetheine phosphatase (EC 3.1.3.-) PANK4 Canis lupus familiaris (Dog) (Canis familiaris) coenzyme A biosynthetic process [GO:0015937] cytoplasm [GO:0005737] ATP binding [GO:0005524]; pantothenate kinase activity [GO:0004594] SFDYSGK 9.989999771 1.22E-13 804.1005928 10.1372 0 9.942896 11.43108 7.932647 A0A8C0NDT3 A0A8C0NDT3_CANLF 60S ribosomal export protein NMD3 NMD3 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] cytoplasm [GO:0005737]; nucleus [GO:0005634] ribosomal large subunit binding [GO:0043023] NVNIYR 1.74000001 0.089125576 779.4254852 15.30406 16.4489 14.85969 14.52728 14.70415 A0A8I3MW53 A0A8I3MW53_CANLF 60S ribosomal protein L10a ZNF112 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] metal ion binding [GO:0046872] STDLNIHCRVHTGEKPYK 2.589999914 0.15456733 2155.534889 15.52335 16.3777 17.4866 0 0 A0A8C0S705 A0A8C0S705_CANLF 60S ribosomal protein L19 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] NYNSLSLVCT 8.609999657 0.109392504 1171.711856 11.13148 15.7486 16.45605 13.38883 16.37655 A0A8C0M0W2 A0A8C0M0W2_CANLF A to I editase domain-containing protein LOC119876313 Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] adenosine deaminase activity [GO:0004000]; RNA binding [GO:0003723] MASPAAPGPGADDSGRR 6.119999886 0 1627.617798 12.4916 13.41805 0 0 11.31272 A0A8C0PXC6 A0A8C0PXC6_CANLF A-kinase anchor inhibitor 1 AKAIN1 Canis lupus familiaris (Dog) (Canis familiaris) DAPSGIR 4.21999979 0.328484542 714.7167577 15.05262 0 12.55951 14.09016 0 A0A8I3NIN3 A0A8I3NIN3_CANLF A-kinase anchoring protein 9 AKAP9 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to cAMP [GO:0071320]; maintenance of centrosome location [GO:0051661]; microtubule nucleation [GO:0007020]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; protein-containing complex localization [GO:0031503]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of Golgi organization [GO:1903358]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; signal transduction [GO:0007165] centrosome [GO:0005813]; cis-Golgi network [GO:0005801]; glutamatergic synapse [GO:0098978]; Golgi stack [GO:0005795]; voltage-gated potassium channel complex [GO:0008076] DNA binding [GO:0003677]; molecular adaptor activity [GO:0060090]; potassium channel regulator activity [GO:0015459]; protein kinase A regulatory subunit binding [GO:0034237]; transmembrane transporter binding [GO:0044325] LQMEAQR 15.18999958 0.133417101 875.5985291 0 16.5826 15.64796 0 15.94785 A0A8C0MUL3 A0A8C0MUL3_CANLF A-kinase interacting protein 1 AKIP1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of non-canonical NF-kappaB signal transduction [GO:1901222] MENCLAAAALNGVDRR 3.74000001 0 1757.22743 17.05932 17.05535 15.80922 20.77279 17.36304 A0A8C0MDD3 A0A8C0MDD3_CANLF AAA+ ATPase domain-containing protein DNAH3 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] SLMSQAVKDTR 4.400000095 0.267022852 1234.911559 13.52317 13.77209 16.31416 13.98583 14.1939 A0A8C0NVT2 A0A8C0NVT2_CANLF AAA+ ATPase domain-containing protein RFC4 Canis lupus familiaris (Dog) (Canis familiaris) DNA replication [GO:0006260] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677] IIEPLTSR 8.210000038 0.182977715 929.905942 16.05811 17.77744 15.60053 16.68205 16.24664 A0A8C0N838 A0A8C0N838_CANLF AAA+ ATPase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] GSAPQYVR 3.170000076 0.129118307 877.6811121 17.00877 14.27364 11.80788 15.50253 15.13862 A0A8C0ND13 A0A8C0ND13_CANLF ABC transporter domain-containing protein ABCA15 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] IAIMVKGSLR 6.639999866 0.242369833 1104.858649 15.3927 10.57417 16.61829 0 0 A0A8C0MP50 A0A8C0MP50_CANLF ABC transporter domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] ELLMMEK 8.289999962 0.185877271 925.5838997 15.70448 17.31343 15.57323 14.59887 15.38041 A0A8C0P7V9 A0A8C0P7V9_CANLF ACOT2 thioesterase Canis lupus familiaris (Dog) (Canis familiaris) acyl-CoA metabolic process [GO:0006637] thiolester hydrolase activity [GO:0016790] SFIPVER 8.420000076 0.229139382 846.5595024 16.01355 16.70135 16.12786 15.42546 14.92225 A0A8C0Q7I1 A0A8C0Q7I1_CANLF ADAM metallopeptidase domain 19 ADAM19 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] GTHVYR 5.570000172 0.270155719 732.570538 15.32163 13.52976 15.84086 14.22278 14.68992 A0A8C0TE92 A0A8C0TE92_CANLF ADAM metallopeptidase domain 20 LOC486076 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] ITDRSIVK 8.06000042 0.272212072 932.7231773 0 15.73371 16.88936 16.23574 15.06082 A0A8C0RED4 A0A8C0RED4_CANLF ADAM metallopeptidase domain 22 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metalloendopeptidase activity [GO:0004222] NTEGPYFR 7.239999771 0.229732004 984.1096584 15.67873 14.11359 14.25315 10.91988 13.62099 A0A8C0MFB3 A0A8C0MFB3_CANLF ADAM metallopeptidase with thrombospondin type 1 motif 2 ADAMTS2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] EVVSMK 18.31999969 0.187313207 707.5127862 20.14993 20.29243 22.2102 19.79704 17.81158 A0A8I3Q4T9 A0A8I3Q4T9_CANLF ADAM metallopeptidase with thrombospondin type 1 motif 20 ADAMTS20 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; extracellular matrix organization [GO:0030198]; melanocyte differentiation [GO:0030318]; negative regulation of apoptotic process [GO:0043066]; positive regulation of melanocyte differentiation [GO:0045636]; positive regulation of signal transduction [GO:0009967]; proteolysis [GO:0006508]; signal transduction [GO:0007165] extracellular space [GO:0005615] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] EMVLGHPSK 12.75 0.03508271 997.1822524 12.81328 14.37107 13.74865 13.75779 14.3634 A0A8C0PDZ3 A0A8C0PDZ3_CANLF AIG1-type G domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GTP binding [GO:0005525] IILVGK 16.54999924 0.410310629 642.7822912 15.27852 15.98013 16.33137 0 16.72372 A0A8C0NGD3 A0A8C0NGD3_CANLF ANKH inorganic pyrophosphate transport regulator ANKH Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] phosphate ion transmembrane transporter activity [GO:0015114] NVGLVFVNSK 5.510000229 0 1075.416062 0 15.89077 19.3178 20.0035 16.29242 A0A8I3NC69 A0A8I3NC69_CANLF APC regulator of WNT signaling pathway 2 APC2 Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; Wnt signaling pathway [GO:0016055] catenin complex [GO:0016342]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; filamentous actin [GO:0031941]; Golgi apparatus [GO:0005794]; intercellular bridge [GO:0045171]; lamellipodium membrane [GO:0031258]; midbody [GO:0030496]; perinuclear region of cytoplasm [GO:0048471] beta-catenin binding [GO:0008013]; microtubule binding [GO:0008017] VPAVLR 9.340000153 0.1510167 655.510883 19.11147 17.14563 0 16.86238 14.62131 A0A8C0MY24 A0A8C0MY24_CANLF ARID domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677] MAPPIK 10.27999973 0.231010144 672.9565099 15.56013 16.75313 14.27418 15.50048 14.8476 A0A8C0PR12 A0A8C0PR12_CANLF ASH1 like histone lysine methyltransferase ASH1L Canis lupus familiaris (Dog) (Canis familiaris) decidualization [GO:0046697]; flagellated sperm motility [GO:0030317]; inflammatory response [GO:0006954]; MAPK cascade [GO:0000165]; negative regulation of acute inflammatory response [GO:0002674]; negative regulation of MAPK cascade [GO:0043409]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; single fertilization [GO:0007338]; skeletal system development [GO:0001501]; tarsal gland development [GO:1903699]; transcription by RNA polymerase II [GO:0006366]; uterine gland development [GO:1903709]; uterus morphogenesis [GO:0061038] Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K9 methyltransferase activity [GO:0046974]; metal ion binding [GO:0046872] DKLDIFR 24.47999954 0.099959954 905.8772185 16.71024 15.43529 0 15.89597 0 A0A8C0Q800 A0A8C0Q800_CANLF ASXL transcriptional regulator 1 ASXL1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] MHSGELGFR 2.890000105 0.233262319 1033.974015 16.58196 14.53369 13.02923 15.0049 13.41992 A0A8C0NNR5 A0A8C0NNR5_CANLF ATP binding cassette subfamily A member 1 ABCA1 Canis lupus familiaris (Dog) (Canis familiaris) "adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to retinoic acid [GO:0071300]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; endosomal transport [GO:0016197]; export across plasma membrane [GO:0140115]; high-density lipoprotein particle assembly [GO:0034380]; intracellular cholesterol transport [GO:0032367]; lipoprotein biosynthetic process [GO:0042158]; lysosome organization [GO:0007040]; peptide secretion [GO:0002790]; phagocytosis, engulfment [GO:0006911]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; phospholipid translocation [GO:0045332]; platelet dense granule organization [GO:0060155]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of high-density lipoprotein particle assembly [GO:0090108]; protein secretion [GO:0009306]; regulation of Cdc42 protein signal transduction [GO:0032489]; response to laminar fluid shear stress [GO:0034616]; reverse cholesterol transport [GO:0043691]; signal release [GO:0023061]" endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335] ABC-type transporter activity [GO:0140359]; apolipoprotein A-I binding [GO:0034186]; apolipoprotein A-I receptor activity [GO:0034188]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase binding [GO:0051117]; cholesterol transfer activity [GO:0120020]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine floppase activity [GO:0090554]; phosphatidylserine floppase activity [GO:0090556]; protein transmembrane transporter activity [GO:0008320]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267]; sphingolipid floppase activity [GO:0046623]; syntaxin binding [GO:0019905] NISDYLVK 16.14999962 0.161371872 951.8265818 16.45093 15.76137 16.83705 17.72223 16.55441 A0A8C0Q8M4 A0A8C0Q8M4_CANLF ATP binding cassette subfamily A member 4 ABCA4 Canis lupus familiaris (Dog) (Canis familiaris) phospholipid transfer to membrane [GO:0006649]; phospholipid translocation [GO:0045332]; photoreceptor cell maintenance [GO:0045494]; retinal metabolic process [GO:0042574]; visual perception [GO:0007601] cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886] 11-cis retinal binding [GO:0005502]; ABC-type transporter activity [GO:0140359]; all-trans retinal binding [GO:0005503]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; N-retinylidene-phosphatidylethanolamine flippase activity [GO:0140347]; phosphatidylethanolamine flippase activity [GO:0090555] TLRLTSK 5.730000019 0.047879314 818.3537177 15.50997 16.99071 16.65495 16.83252 17.38384 A0A8C0PKJ3 A0A8C0PKJ3_CANLF ATP binding cassette subfamily D member 2 ABCD2 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid beta-oxidation [GO:0006635]; myelin maintenance [GO:0043217]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neuron projection maintenance [GO:1990535]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of unsaturated fatty acid biosynthetic process [GO:2001280]; response to bacterium [GO:0009617]; very long-chain fatty acid catabolic process [GO:0042760] membrane [GO:0016020]; peroxisome [GO:0005777] ABC-type transporter activity [GO:0140359]; acyl-CoA hydrolase activity [GO:0047617]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; protein homodimerization activity [GO:0042803] QSGHRK 9.319999695 0.027854571 711.2042891 16.14042 14.56494 14.44288 14.10984 14.94231 A0A8C0SWP7 A0A8C0SWP7_CANLF ATP synthase lipid-binding protein (ATPase protein 9) (ATPase subunit c) ATP5MC3 Canis lupus familiaris (Dog) (Canis familiaris) proton motive force-driven ATP synthesis [GO:0015986] "mitochondrial membrane [GO:0031966]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]" lipid binding [GO:0008289]; proton transmembrane transporter activity [GO:0015078] MLACAK 6.670000076 0.31759096 692.2723481 19.01714 16.37682 16.55228 17.37592 16.82494 A0A8P0NJK0 A0A8P0NJK0_CANLF ATP synthase mitochondrial F1 complex assembly factor 2 ATPAF2 Canis lupus familiaris (Dog) (Canis familiaris) proton-transporting ATP synthase complex assembly [GO:0043461] mitochondrion [GO:0005739] GALAAPAPPGPTPQAPAR 5.809999943 0 1640.441859 0 16.22978 0 15.74939 14.15097 A0A8I3PIY6 A0A8I3PIY6_CANLF ATP-dependent DNA helicase (EC 3.6.4.12) RECQL5 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to camptothecin [GO:0072757]; cellular response to xenobiotic stimulus [GO:0071466]; chromosome separation [GO:0051304]; mitotic DNA-templated DNA replication [GO:1990506]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; replication fork [GO:0005657]; transcription preinitiation complex [GO:0097550] ATP binding [GO:0005524]; DNA helicase activity [GO:0003678]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676]; RNA polymerase II complex binding [GO:0000993] RVGAGFPR 8.199999809 0.272118295 858.8583259 19.43004 19.3081 17.95748 19.17843 18.74108 A0A8C0PHR2 A0A8C0PHR2_CANLF ATP-dependent RNA helicase DHX30 (EC 3.6.4.13) (DEAH box protein 30) DHX30 Canis lupus familiaris (Dog) (Canis familiaris) central nervous system development [GO:0007417]; mitochondrial large ribosomal subunit assembly [GO:1902775] cytosol [GO:0005829]; mitochondrial nucleoid [GO:0042645]; ribonucleoprotein granule [GO:0035770] ATP binding [GO:0005524]; chromatin binding [GO:0003682]; double-stranded RNA binding [GO:0003725]; hydrolase activity [GO:0016787]; RNA helicase activity [GO:0003724] LVLMSATGDNERFSR 6.980000019 0.341041571 1711.201376 14.64811 12.80025 15.82534 0 18.1229 A0A8C0TNV1 A0A8C0TNV1_CANLF ATP-dependent RNA helicase (EC 3.6.4.13) DDX55 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723] LEDMFR 21.40999985 0.313407659 810.486813 20.28569 16.42712 18.42577 16.64535 17.83684 A0A8C0PFA0 A0A8C0PFA0_CANLF ATP6V1F neighbor SPMIP1 ATP6V1FNB Canis lupus familiaris (Dog) (Canis familiaris) LDMPEMR 10.86999989 0.172155135 922.4559105 16.18764 17.1724 15.24835 15.32288 16.15675 A0A8I3NEW2 A0A8I3NEW2_CANLF ATPase family AAA domain containing 5 ATAD5 Canis lupus familiaris (Dog) (Canis familiaris) cell population proliferation [GO:0008283]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; isotype switching [GO:0045190]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; nuclear DNA replication [GO:0033260]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell cycle G2/M phase transition [GO:1902751]; positive regulation of DNA replication [GO:0045740]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; regulation of mitotic cell cycle phase transition [GO:1901990]; signal transduction in response to DNA damage [GO:0042770] Elg1 RFC-like complex [GO:0031391]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA clamp unloader activity [GO:0061860] RSPTDLPK 9.329999924 1.22E-13 914.4166822 15.21426 15.09328 14.74178 16.26698 15.47118 A0A0X9NPA2 A0A0X9NPA2_CANLF Acetylcholine receptor subunit epsilon Canis lupus familiaris (Dog) (Canis familiaris) postsynaptic membrane [GO:0045211] acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; transmembrane signaling receptor activity [GO:0004888] LPVPDR 7.949999809 0.030502813 695.3384627 16.55397 15.61394 15.12533 14.64776 15.52629 A0A8C0RF82 A0A8C0RF82_CANLF Aconitate decarboxylase 1 ACOD1 Canis lupus familiaris (Dog) (Canis familiaris) defense response [GO:0006952]; positive regulation of antimicrobial humoral response [GO:0002760]; tolerance induction to lipopolysaccharide [GO:0072573] aconitate decarboxylase activity [GO:0047613]; protein homodimerization activity [GO:0042803] MMLKSVTESFAR 1.379999995 0.315967753 1431.68157 18.12975 16.50327 0 16.32808 15.08683 A0A8C0NJP5 A0A8C0NJP5_CANLF Actin interacting protein 3-like C-terminal domain-containing protein KIAA1217 Canis lupus familiaris (Dog) (Canis familiaris) MPVPMGSK 4.409999847 0.390361987 860.2974778 17.02737 16.50795 17.7736 16.7189 16.88469 A0A8C0NU57 A0A8C0NU57_CANLF Activating transcription factor 2 ATF2 Canis lupus familiaris (Dog) (Canis familiaris) abducens nucleus development [GO:0021742]; adipose tissue development [GO:0060612]; apoptotic process involved in development [GO:1902742]; BMP signaling pathway [GO:0030509]; brainstem development [GO:0003360]; cellular lipid metabolic process [GO:0044255]; cellular response to anisomycin [GO:0072740]; cellular response to leucine starvation [GO:1990253]; cellular response to oxidative stress [GO:0034599]; cellular response to virus [GO:0098586]; detection of cell density [GO:0060245]; facial nucleus development [GO:0021754]; growth plate cartilage chondrocyte differentiation [GO:0003418]; growth plate cartilage chondrocyte proliferation [GO:0003419]; hematopoietic progenitor cell differentiation [GO:0002244]; hepatocyte apoptotic process [GO:0097284]; hypoglossal nucleus development [GO:0021743]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway in response to hypoxia [GO:1990144]; JNK cascade [GO:0007254]; liver development [GO:0001889]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; motor neuron apoptotic process [GO:0097049]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of angiogenesis [GO:0016525]; neurofilament cytoskeleton organization [GO:0060052]; NK T cell differentiation [GO:0001865]; outflow tract morphogenesis [GO:0003151]; p38MAPK cascade [GO:0038066]; positive regulation of cardiac muscle myoblast proliferation [GO:0110024]; positive regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902110]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transforming growth factor beta2 production [GO:0032915]; protein import into nucleus [GO:0006606]; response to organic cyclic compound [GO:0014070]; response to osmotic stress [GO:0006970]; transcription initiation-coupled chromatin remodeling [GO:0045815]; vacuole organization [GO:0007033]; white fat cell differentiation [GO:0050872] H4 histone acetyltransferase complex [GO:1902562]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575]; site of double-strand break [GO:0035861] "cAMP response element binding [GO:0035497]; cAMP response element binding protein binding [GO:0008140]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; histone H2B acetyltransferase activity [GO:0044013]; histone H4 acetyltransferase activity [GO:0010485]; leucine zipper domain binding [GO:0043522]; promoter-specific chromatin binding [GO:1990841]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]" QLLLAHK 1.299999952 0.37735038 823.9846072 17.27099 0 15.9198 16.805 18.0672 A0A8C0PN60 A0A8C0PN60_CANLF Activity dependent neuroprotector homeobox Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] IHNFTSK 3 0.186994609 846.896112 19.14724 16.19006 16.20633 17.01997 16.74112 A0A8C0N768 A0A8C0N768_CANLF Acyl-CoA-binding domain-containing protein 5 Canis lupus familiaris (Dog) (Canis familiaris) pexophagy [GO:0000425] peroxisomal membrane [GO:0005778] fatty-acyl-CoA binding [GO:0000062] VIQSLPK 10.88000011 1.23E-13 783.3361107 16.63969 15.64807 15.68181 16.21128 16.41616 A0A8C0RH79 A0A8C0RH79_CANLF Acyltransferase (EC 2.3.1.-) DGAT2L6 Canis lupus familiaris (Dog) (Canis familiaris) regulation of signal transduction [GO:0009966] endoplasmic reticulum membrane [GO:0005789] O-acyltransferase activity [GO:0008374] THDLPPK 7.119999886 0.407301748 807.0145962 14.66797 15.13309 16.64244 14.57451 16.13169 A0A8C0PHT0 A0A8C0PHT0_CANLF "Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1" APPL1 Canis lupus familiaris (Dog) (Canis familiaris) adiponectin-activated signaling pathway [GO:0033211]; cell cycle [GO:0007049]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; insulin receptor signaling pathway [GO:0008286]; maintenance of synapse structure [GO:0099558]; negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis [GO:1905450]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of glucose import [GO:0046326]; positive regulation of macropinocytosis [GO:1905303]; positive regulation of melanin biosynthetic process [GO:0048023]; protein import into nucleus [GO:0006606]; regulation of fibroblast migration [GO:0010762]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of toll-like receptor 4 signaling pathway [GO:0034143]; transforming growth factor beta receptor signaling pathway [GO:0007179] cytosol [GO:0005829]; early endosome membrane [GO:0031901]; early phagosome [GO:0032009]; glutamatergic synapse [GO:0098978]; macropinosome [GO:0044354]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726] beta-tubulin binding [GO:0048487]; phosphatidylinositol binding [GO:0035091]; phosphatidylserine binding [GO:0001786]; protein homodimerization activity [GO:0042803]; protein kinase B binding [GO:0043422]; protein-containing complex binding [GO:0044877] EILTLK 8.340000153 0.231086432 717.0926678 16.70276 15.1156 0 16.3365 17.76111 A0A8I3PMB3 A0A8I3PMB3_CANLF Adaptor related protein complex 4 subunit beta 1 AP4B1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; protein localization to somatodendritic compartment [GO:0061938]; protein targeting [GO:0006605]; vesicle-mediated transport [GO:0016192] AP-4 adaptor complex [GO:0030124]; clathrin adaptor complex [GO:0030131]; cytoplasmic side of trans-Golgi network transport vesicle membrane [GO:0098541]; cytosol [GO:0005829]; trans-Golgi network [GO:0005802] YQGAEHR 2.910000086 0.058295708 859.5112719 19.21423 17.32467 18.26089 18.67071 17.69351 A0A8C0MFX2 A0A8C0MFX2_CANLF Adenosine kinase (AK) (EC 2.7.1.20) (Adenosine 5'-phosphotransferase) ADK Canis lupus familiaris (Dog) (Canis familiaris) AMP salvage [GO:0044209]; phosphorylation [GO:0016310]; purine ribonucleoside salvage [GO:0006166] nucleus [GO:0005634] adenosine kinase activity [GO:0004001]; ATP binding [GO:0005524] KTQALPK 6.630000114 0.352479205 786.0338093 15.41247 14.86346 14.60316 15.90617 15.26343 A0A8C0PEZ7 A0A8C0PEZ7_CANLF Adenylyltransferase and sulfurtransferase MOCS3 (Molybdenum cofactor synthesis protein 3) [Includes: Molybdopterin-synthase adenylyltransferase (EC 2.7.7.80) (Adenylyltransferase MOCS3) (Sulfur carrier protein MOCS2A adenylyltransferase); Molybdopterin-synthase sulfurtransferase (EC 2.8.1.11) (Sulfurtransferase MOCS3) (Sulfur carrier protein MOCS2A sulfurtransferase)] MOCS3 UBA4 Canis lupus familiaris (Dog) (Canis familiaris) Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; tRNA wobble position uridine thiolation [GO:0002143] cytosol [GO:0005829] adenylyltransferase activity [GO:0070566]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; molybdopterin-synthase sulfurtransferase activity [GO:0061604]; URM1 activating enzyme activity [GO:0042292] LGNDSQKAVK 9.220000267 0.269554404 1060.161813 15.88307 15.2745 14.20345 14.64116 16.37396 A0A8C0S6C9 A0A8C0S6C9_CANLF Adhesion G protein-coupled receptor G3 ADGRG3 Canis lupus familiaris (Dog) (Canis familiaris) B cell differentiation [GO:0030183]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; regulation of cell migration [GO:0030334] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] ASGMENSK 3.440000057 0.214421446 838.8068862 15.4202 13.25844 15.30707 16.75093 14.89773 A0A8I3NZJ4 A0A8I3NZJ4_CANLF Adhesion G protein-coupled receptor V1 ADGRV1 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605] cell surface [GO:0009986]; cytoplasm [GO:0005737]; membrane [GO:0016020]; receptor complex [GO:0043235] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] KLSSTIYR 11.31000042 0.27540568 968.3145126 15.54127 15.85775 17.20511 15.72148 14.0244 A0A8C0Q5R3 A0A8C0Q5R3_CANLF "Afadin, adherens junction formation factor" Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; signal transduction [GO:0007165] cell-cell junction [GO:0005911]; membrane [GO:0016020] AGTPASTLTK 7.960000038 0 946.6222563 19.51466 0 16.43493 16.68228 18.89272 A0A8C0MGC4 A0A8C0MGC4_CANLF Aftiphilin clathrin-binding box domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) intracellular transport [GO:0046907] trans-Golgi network membrane [GO:0032588] clathrin binding [GO:0030276] SQKARPRPR 4.739999771 0.214450127 1095.801375 13.82815 0 11.68943 14.44495 14.18386 P49822 ALBU_CANLF Albumin (allergen Can f 3) ALB Canis lupus familiaris (Dog) (Canis familiaris) cellular response to calcium ion starvation [GO:0072732]; cellular response to starvation [GO:0009267]; negative regulation of mitochondrial depolarization [GO:0051902] cytoplasm [GO:0005737]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991] DNA binding [GO:0003677]; enterobactin binding [GO:1903981]; fatty acid binding [GO:0005504]; metal ion binding [GO:0046872]; pyridoxal phosphate binding [GO:0030170]; toxic substance binding [GO:0015643] APQVSTPTLVEVSR 27.73999977 0.665133602 1482.893993 19.05391 17.24912 15.736 17.21775 0 A0A8C0TQQ5 A0A8C0TQQ5_CANLF Alkaline phosphatase (EC 3.1.3.1) Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886]; side of membrane [GO:0098552] metal ion binding [GO:0046872]; phosphatase activity [GO:0016791] LQPIQTAAK 1.269999981 0.264896584 968.3579327 13.74143 15.13335 16.16239 17.2349 15.40505 A0A8C0NAD2 A0A8C0NAD2_CANLF "Alpha 1,4-glycosyltransferase domain-containing protein" Canis lupus familiaris (Dog) (Canis familiaris) epithelial cell proliferation [GO:0050673]; negative regulation of epithelial cell proliferation [GO:0050680]; protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139] acetylglucosaminyltransferase activity [GO:0008375] LGLGNT 3.160000086 0.041137335 573.301384 14.69655 14.96146 15.444 14.19576 0 A0A8C0SSL6 A0A8C0SSL6_CANLF "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A (EC 2.4.1.145) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa)" MGAT4A Canis lupus familiaris (Dog) (Canis familiaris) N-glycan processing [GO:0006491]; protein N-linked glycosylation [GO:0006487] extracellular region [GO:0005576]; membrane [GO:0016020] "alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity [GO:0008454]; metal ion binding [GO:0046872]" VCNPEKDAK 3.029999971 0.288624837 1060.344352 15.16891 14.4078 16.32091 14.78467 0 A0A8C0RR22 A0A8C0RR22_CANLF Alpha-2-macroglobulin like 1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] GEKGFIPAK 3.74000001 0.098813878 947.119962 15.06179 16.34725 16.31557 15.26986 14.21319 Q8MJU5 FETA_CANLF Alpha-fetoprotein (Alpha-1-fetoprotein) (Alpha-fetoglobulin) AFP Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; extracellular space [GO:0005615] metal ion binding [GO:0046872] YIYEIAR 14.64999962 0.05481629 927.7305443 0 12.96961 18.252 17.66671 15.25468 A0A8C0Q290 A0A8C0Q290_CANLF Alpha/beta hydrolase fold-3 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] carboxylic ester hydrolase activity [GO:0052689] DDSLLYK 3.970000029 0.306038857 853.7696729 0 15.72469 15.64686 17.39717 16.52787 A0A8C0LU59 A0A8C0LU59_CANLF Amidohydrolase-related domain-containing protein CRMP1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810]" GPAGTSLESK 6.5 0 947.0256257 16.62761 14.64588 18.02157 0 19.0359 P79143 AMPN_CANLF Aminopeptidase N (AP-N) (cAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (CD antigen CD13) ANPEP Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] metalloaminopeptidase activity [GO:0070006]; peptide binding [GO:0042277]; virus receptor activity [GO:0001618]; zinc ion binding [GO:0008270] GFYISK 4.920000076 0.062516458 715.4808353 16.31948 16.39744 17.22236 14.40635 15.37664 A0A8C0MP22 A0A8C0MP22_CANLF Amyloid beta precursor protein binding family B member 1 APBB1 Canis lupus familiaris (Dog) (Canis familiaris) DNA damage response [GO:0006974]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron projection development [GO:0010976] endoplasmic reticulum [GO:0005783]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202] amyloid-beta binding [GO:0001540]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; molecular adaptor activity [GO:0060090]; proline-rich region binding [GO:0070064]; ubiquitin protein ligase binding [GO:0031625] AATAHR 5.880000114 0.247215096 626.6034763 15.48551 16.67726 15.8081 15.14176 14.70813 A0A8C0M3J0 A0A8C0M3J0_CANLF Anaphase-promoting complex subunit 4-like WD40 domain-containing protein THOC3 Canis lupus familiaris (Dog) (Canis familiaris) mRNA export from nucleus [GO:0006406] TLSFSHDGK 12.27999973 1.23E-13 991.1370318 12.52 13.70025 12.54053 13.61422 0 Q7YR70 AAMP_CANLF Angio-associated migratory cell protein AAMP Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; positive regulation of endothelial cell migration [GO:0010595]; smooth muscle cell migration [GO:0014909] cell surface [GO:0009986]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886] heparin binding [GO:0008201] VPNGDCK 2.519999981 0.151855901 788.5863137 15.72786 14.91635 17.30835 14.62651 14.84048 A0A8C0N3B0 A0A8C0N3B0_CANLF Angiomotin C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] recycling endosome [GO:0055037] GAIEDQRR 4.460000038 0.201531547 944.9289652 15.48133 14.68136 17.0495 15.92649 14.98291 A0A8C0M1K7 A0A8C0M1K7_CANLF Angiopoietin like 3 ANGPTL3 Canis lupus familiaris (Dog) (Canis familiaris) artery morphogenesis [GO:0048844]; cell-matrix adhesion [GO:0007160]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; fatty acid metabolic process [GO:0006631]; glycerol metabolic process [GO:0006071]; lipid storage [GO:0019915]; phospholipid catabolic process [GO:0009395]; phospholipid homeostasis [GO:0055091]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of lipid catabolic process [GO:0050996]; triglyceride homeostasis [GO:0070328] cell surface [GO:0009986]; early endosome [GO:0005769]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794] growth factor activity [GO:0008083]; integrin binding [GO:0005178]; phospholipase inhibitor activity [GO:0004859] VRYLEK 1.809999943 0.005254838 807.416979 15.79371 0 16.32392 14.72151 14.93751 A0A8I3P2V3 A0A8I3P2V3_CANLF Anion exchange protein SLC4A8 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of synaptic vesicle exocytosis [GO:2000302]; regulation of intracellular pH [GO:0051453]; regulation of membrane potential [GO:0042391] basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; lateral plasma membrane [GO:0016328]; neuronal cell body membrane [GO:0032809]; presynaptic membrane [GO:0042734] "sodium,bicarbonate:chloride antiporter activity [GO:0140892]; sodium:bicarbonate symporter activity [GO:0008510]" VREALLK 14.14999962 0.226901383 828.9105947 18.68209 18.5785 17.51639 20.45724 17.19641 A0A8I3PY50 A0A8I3PY50_CANLF Ankyrin 2 ANK2 Canis lupus familiaris (Dog) (Canis familiaris) atrial cardiac muscle cell action potential [GO:0086014]; atrial septum development [GO:0003283]; positive regulation of gene expression [GO:0010628]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to plasma membrane [GO:0072659]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; ventricular cardiac muscle cell action potential [GO:0086005] basolateral plasma membrane [GO:0016323]; cytoskeleton [GO:0005856] phosphorylation-dependent protein binding [GO:0140031]; protein kinase binding [GO:0019901]; spectrin binding [GO:0030507]; transmembrane transporter binding [GO:0044325] GAPLLARTK 10.18999958 0.292104523 925.6598687 14.75827 16.06115 17.25225 14.63761 15.95706 A0A8C0P2B0 A0A8C0P2B0_CANLF Ankyrin 2 Canis lupus familiaris (Dog) (Canis familiaris) localization [GO:0051179]; signal transduction [GO:0007165] cytoskeleton [GO:0005856]; membrane [GO:0016020] HVPASPSSK 3.970000029 0.02817015 909.9536639 15.07398 12.00647 15.90032 14.35589 14.43906 A0A8I3MU78 A0A8I3MU78_CANLF Ankyrin 3 ANK3 Canis lupus familiaris (Dog) (Canis familiaris) Golgi to plasma membrane protein transport [GO:0043001]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; plasma membrane organization [GO:0007009]; signal transduction [GO:0007165] axon initial segment [GO:0043194]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; lateral plasma membrane [GO:0016328]; sarcolemma [GO:0042383] structural constituent of cytoskeleton [GO:0005200] EIRHVEK 5.420000076 0.292108789 911.748364 15.02563 13.5419 13.91804 14.42093 15.42226 A0A8C0NYX8 A0A8C0NYX8_CANLF Ankyrin repeat and MYND domain containing 2 ANKMY2 Canis lupus familiaris (Dog) (Canis familiaris) cilium [GO:0005929] enzyme binding [GO:0019899]; metal ion binding [GO:0046872] DMNEVLAMK 3.079999924 0.25312895 1083.564986 14.17334 14.83383 14.65103 15.16026 14.35253 A0A8C0MBP7 A0A8C0MBP7_CANLF Ankyrin repeat domain 12 ANKRD12 Canis lupus familiaris (Dog) (Canis familiaris) EGINVTNPK 8.869999886 1.22E-13 971.294253 15.03065 12.29951 13.39252 14.89524 12.7464 A0A8C0Z617 A0A8C0Z617_CANLF Ankyrin repeat domain 13A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VCALVSR 2.00999999 0.44068202 805.025482 17.75776 16.7444 16.19007 15.43916 15.68445 A0A8C0QGV1 A0A8C0QGV1_CANLF Ankyrin repeat domain 17 ANKRD17 Canis lupus familiaris (Dog) (Canis familiaris) blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] chromatin [GO:0000785]; cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682]; RNA binding [GO:0003723] GAHIDVR 5.210000038 0.365138777 766.7334271 21.68632 15.0669 16.44678 17.22918 21.15316 A0A8C0PD06 A0A8C0PD06_CANLF Ankyrin repeat domain 28 ANKRD28 Canis lupus familiaris (Dog) (Canis familiaris) RVQAGPEGR 10.77999973 0.488189176 969.9836439 14.48299 0 17.34708 0 0 A0A8C0NBI0 A0A8C0NBI0_CANLF Ankyrin repeat domain 37 ANKRD37 Canis lupus familiaris (Dog) (Canis familiaris) GLGGAR 2.970000029 0.246517921 530.3550047 13.51398 12.99834 15.52856 15.15046 13.62014 A0A8C0MMB0 A0A8C0MMB0_CANLF Ankyrin repeat domain 50 ANKRD50 Canis lupus familiaris (Dog) (Canis familiaris) GLVAQICR 1.24000001 0.295182253 915.4163752 12.71309 15.98713 15.86346 15.96244 15.19357 A0A8C0N3P4 A0A8C0N3P4_CANLF Ankyrin repeat domain 54 ANKRD54 Canis lupus familiaris (Dog) (Canis familiaris) nucleocytoplasmic transport [GO:0006913]; positive regulation of erythrocyte differentiation [GO:0045648]; regulation of intracellular signal transduction [GO:1902531] cytoplasm [GO:0005737]; midbody [GO:0030496]; nucleus [GO:0005634] protein kinase regulator activity [GO:0019887]; protein-containing complex binding [GO:0044877] TPLHLAKSK 5.130000114 0 995.5159291 12.79503 13.23535 12.10559 15.02572 12.62202 A0A8C0PBS3 A0A8C0PBS3_CANLF Anoctamin ANO3 Canis lupus familiaris (Dog) (Canis familiaris) calcium activated galactosylceramide scrambling [GO:0061591]; calcium activated phosphatidylcholine scrambling [GO:0061590]; establishment of localization in cell [GO:0051649] membrane [GO:0016020] phospholipid scramblase activity [GO:0017128]; protein dimerization activity [GO:0046983] HLLYER 7.429999828 0.381350537 829.113392 14.39287 17.15631 17.63403 16.25487 14.8703 A0A8C0NEB6 A0A8C0NEB6_CANLF Anoctamin ANO4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] protein dimerization activity [GO:0046983] QISRFR 6.929999828 0.174108324 806.7657373 17.95314 16.60417 18.64394 17.73507 17.24494 A0A8C0Q1U9 A0A8C0Q1U9_CANLF Apolipoprotein A-I (Apolipoprotein A1) APOA1 Canis lupus familiaris (Dog) (Canis familiaris) adrenal gland development [GO:0030325]; blood vessel endothelial cell migration [GO:0043534]; cholesterol biosynthetic process [GO:0006695]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol import [GO:0070508]; endothelial cell proliferation [GO:0001935]; G protein-coupled receptor signaling pathway [GO:0007186]; glucocorticoid metabolic process [GO:0008211]; high-density lipoprotein particle assembly [GO:0034380]; high-density lipoprotein particle remodeling [GO:0034375]; integrin-mediated signaling pathway [GO:0007229]; lipid storage [GO:0019915]; lipoprotein biosynthetic process [GO:0042158]; negative regulation of cell adhesion molecule production [GO:0060354]; negative regulation of cytokine production involved in immune response [GO:0002719]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; negative regulation of very-low-density lipoprotein particle remodeling [GO:0010903]; phosphatidylcholine biosynthetic process [GO:0006656]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol metabolic process [GO:0090205]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phospholipid efflux [GO:1902995]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein stabilization [GO:0050821]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of intestinal cholesterol absorption [GO:0030300]; regulation of protein phosphorylation [GO:0001932]; reverse cholesterol transport [GO:0043691]; triglyceride homeostasis [GO:0070328]; vitamin transport [GO:0051180] endocytic vesicle [GO:0030139]; spherical high-density lipoprotein particle [GO:0034366]; very-low-density lipoprotein particle [GO:0034361] amyloid-beta binding [GO:0001540]; apolipoprotein A-I receptor binding [GO:0034191]; chemorepellent activity [GO:0045499]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; high-density lipoprotein particle binding [GO:0008035]; high-density lipoprotein particle receptor binding [GO:0070653]; identical protein binding [GO:0042802]; phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228]; phospholipid binding [GO:0005543] AQLAPYSDDLRER 19.75 0.374229168 1534.114078 19.54817 18.80777 20.94028 18.97086 18.54563 A0A8C0MGN3 A0A8C0MGN3_CANLF Apoptosis regulatory protein Siva SIVA1 Canis lupus familiaris (Dog) (Canis familiaris) extrinsic apoptotic signaling pathway [GO:0097191] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] CD27 receptor binding [GO:0005175]; metal ion binding [GO:0046872]; tumor necrosis factor receptor binding [GO:0005164]; virus receptor activity [GO:0001618] TKQLLFR 19.51000023 0.362748408 906.5079405 14.49006 15.65964 17.51362 0 16.14043 A0A8C0MY34 A0A8C0MY34_CANLF "Arachidonate 12-lipoxygenase, 12S type" ALOX12 Canis lupus familiaris (Dog) (Canis familiaris) lipid oxidation [GO:0034440] cytoplasm [GO:0005737] "iron ion binding [GO:0005506]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]" AMAQLTYR 2.019999981 0.173240194 968.4175154 15.58014 0 16.95518 14.93609 15.68203 A0A8C0PCQ3 A0A8C0PCQ3_CANLF "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein (Cnt-b) (Centaurin-beta)" ACAP2 Canis lupus familiaris (Dog) (Canis familiaris) endosome membrane [GO:0010008] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] SGLVLQIR 1.330000043 0.342241032 884.1011373 13.40385 15.91234 15.24328 13.25148 14.20699 A0A8I3NAJ2 A0A8I3NAJ2_CANLF "ArfGAP with GTPase domain, ankyrin repeat and PH domain 3" AGAP3 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] KEWWPPIK 10.10999966 0.08520822 1083.159928 13.03201 0 3.976049 0 14.94162 A0A8C0RZU0 A0A8C0RZU0_CANLF Argonaute RISC component 1 AGO1 Canis lupus familiaris (Dog) (Canis familiaris) miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; negative regulation of angiogenesis [GO:0016525]; nuclear-transcribed mRNA catabolic process [GO:0000956]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pre-miRNA processing [GO:0031054]; RISC complex assembly [GO:0070922]; RNA secondary structure unwinding [GO:0010501] cytosol [GO:0005829]; P-body [GO:0000932]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578] core promoter sequence-specific DNA binding [GO:0001046]; double-stranded RNA binding [GO:0003725]; miRNA binding [GO:0035198]; RNA polymerase II complex binding [GO:0000993]; single-stranded RNA binding [GO:0003727] ARPGSPSSR 9.850000381 0 913.6286399 12.72771 12.20441 14.20825 14.92732 12.80832 A0A8C0SXE4 A0A8C0SXE4_CANLF Armadillo repeat-containing domain-containing protein ARMCX4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GNSNAMSK 16.31999969 0.328269938 824.3386338 18.97111 17.66224 16.85697 20.50002 17.81005 A0A8C0NXV9 A0A8C0NXV9_CANLF Aryl hydrocarbon receptor Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904613]; rhythmic process [GO:0048511]; xenobiotic metabolic process [GO:0006805]" cytoplasm [GO:0005737]; nucleus [GO:0005634] nuclear receptor activity [GO:0004879]; protein dimerization activity [GO:0046983] SAGGKHR 10.35999966 0.25175838 712.5109795 0 15.91637 18.22027 15.84486 16.10044 A0A8C0MXR3 A0A8C0MXR3_CANLF Aspartic peptidase DDI1-type domain-containing protein NRIP3 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] aspartic-type endopeptidase activity [GO:0004190] LIMGKTDK 19.89999962 0.361358494 906.4541326 17.48496 16.62965 15.30254 15.60832 15.07878 A0A8C0PFU9 A0A8C0PFU9_CANLF Attractin like 1 ATRNL1 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] carbohydrate binding [GO:0030246] DSFSYEKFNFR 4.53000021 2.46E-13 1440.035428 13.67465 14.96194 0 14.84662 15.93664 A0A8C0P7K5 A0A8C0P7K5_CANLF Autophagy related 16 like 1 ATG16L1 Canis lupus familiaris (Dog) (Canis familiaris) corpus callosum development [GO:0022038]; defense response to virus [GO:0051607]; hippocampus development [GO:0021766]; microautophagy [GO:0016237]; negative stranded viral RNA replication [GO:0039689]; positive regulation of autophagy [GO:0010508]; protein localization to phagophore assembly site [GO:0034497]; xenophagy [GO:0098792] Atg12-Atg5-Atg16 complex [GO:0034274]; autophagosome membrane [GO:0000421]; axoneme [GO:0005930]; endolysosome membrane [GO:0036020]; phagophore assembly site membrane [GO:0034045]; sperm midpiece [GO:0097225]; vacuole-isolation membrane contact site [GO:0120095] GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; protein-membrane adaptor activity [GO:0043495] TLKLWDLR 6.039999962 0.301819621 1044.706701 14.1643 15.68323 16.07427 13.23823 15.40868 A0A8I3Q3W0 A0A8I3Q3W0_CANLF Autophagy related 2A ATG2A Canis lupus familiaris (Dog) (Canis familiaris) autophagosome assembly [GO:0000045]; positive regulation of autophagosome assembly [GO:2000786] endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; organelle membrane contact site [GO:0044232]; phagophore assembly site membrane [GO:0034045] lipid transfer activity [GO:0120013] TGLAGGRR 6.860000134 0.240592616 787.661438 12.25805 14.11505 14.99064 15.95943 16.57155 A0A8I3S578 A0A8I3S578_CANLF B cell scaffold protein with ankyrin repeats 1 BANK1 Canis lupus familiaris (Dog) (Canis familiaris) B cell activation [GO:0042113]; MAPK cascade [GO:0000165]; negative regulation of B cell activation [GO:0050869]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of translational initiation [GO:0045947]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; response to bacterium [GO:0009617] perinuclear region of cytoplasm [GO:0048471] phospholipase binding [GO:0043274]; protease binding [GO:0002020]; protein tyrosine kinase binding [GO:1990782]; signaling adaptor activity [GO:0035591]; signaling receptor binding [GO:0005102] DCIIGK 5.179999828 0 706.2200792 13.22552 13.43646 14.52103 13.95479 14.4537 A0A8C0P8E5 A0A8C0P8E5_CANLF BAH domain-containing protein BAHD1 Canis lupus familiaris (Dog) (Canis familiaris) chromatin binding [GO:0003682] SLPMLSSGPTGR 9.25 0 1201.606654 12.61975 13.32372 17.44074 0 12.42638 A0A8C0SDB2 A0A8C0SDB2_CANLF BAR/IMD domain containing adaptor protein 2 like 1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane organization [GO:0007009] VLGGSRPR 8.739999771 0.140799225 842.3704185 16.79668 16.85777 15.52393 0 0 A0A8I3NVU9 A0A8I3NVU9_CANLF "BCAR3 adaptor protein, NSP family member" BCAR3 Canis lupus familiaris (Dog) (Canis familiaris) endothelin receptor signaling pathway [GO:0086100]; epidermal growth factor receptor signaling pathway [GO:0007173]; insulin receptor signaling pathway [GO:0008286]; lens morphogenesis in camera-type eye [GO:0002089]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; small GTPase mediated signal transduction [GO:0007264] focal adhesion [GO:0005925]; membrane [GO:0016020] guanyl-nucleotide exchange factor activity [GO:0005085]; kinase binding [GO:0019900]; phosphotyrosine residue binding [GO:0001784] LSLTMGGVQAR 2.980000019 0.059266956 1132.598074 14.06601 15.52364 14.03384 13.72204 0 A0A8C0LX14 A0A8C0LX14_CANLF BCL2 interacting protein 1 BNIP1 Canis lupus familiaris (Dog) (Canis familiaris) "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" endoplasmic reticulum membrane [GO:0005789] SNAP receptor activity [GO:0005484] SMSGTIQLGR 7.809999943 0.404865884 1051.03968 16.34656 15.30745 16.87818 16.95789 17.30712 A0A8C0RMQ6 A0A8C0RMQ6_CANLF BCL2 like 14 BCL2L14 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; regulation of apoptotic process [GO:0042981] cytosol [GO:0005829]; intracellular organelle [GO:0043229] protein kinase binding [GO:0019901] SQHWSR 4.360000134 0.194798013 800.6377541 15.91137 15.45569 13.49478 15.00131 17.00189 A0A8C0PAI0 A0A8C0PAI0_CANLF BCL6 corepressor like 1 Canis lupus familiaris (Dog) (Canis familiaris) NLLLPNK 2.900000095 0.321360892 812.0714735 17.49472 16.10699 18.56158 17.40899 19.30115 A0A8C0T8W4 A0A8C0T8W4_CANLF BCLAF1 and THRAP3 family member 3 BCLAF3 Canis lupus familiaris (Dog) (Canis familiaris) TNFRGGR 5.420000076 0.294840994 806.8634124 15.22568 15.44072 14.86163 16.67893 14.68081 A0A8I3PVQ3 A0A8I3PVQ3_CANLF BHLH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]" DRCASGPR 7.170000076 0.401239319 917.3662608 15.47899 16.72574 0 14.48808 14.74259 A0A8C0SZM8 A0A8C0SZM8_CANLF BHLH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "adrenal chromaffin cell differentiation [GO:0061104]; carotid body glomus cell differentiation [GO:0061103]; cell maturation [GO:0048469]; central nervous system neuron development [GO:0021954]; cerebral cortex development [GO:0021987]; cerebral cortex GABAergic interneuron differentiation [GO:0021892]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; lung neuroendocrine cell differentiation [GO:0061100]; motor neuron migration [GO:0097475]; musculoskeletal movement, spinal reflex action [GO:0050883]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neuron differentiation [GO:0045665]; neuroblast fate determination [GO:0007400]; neuroblast proliferation [GO:0007405]; neuron fate specification [GO:0048665]; noradrenergic neuron development [GO:0003358]; noradrenergic neuron fate commitment [GO:0003359]; Notch signaling pathway [GO:0007219]; olfactory pit development [GO:0060166]; oligodendrocyte development [GO:0014003]; peripheral nervous system neuron development [GO:0048935]; positive regulation of cell cycle [GO:0045787]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of epithelial cell differentiation [GO:0030856]; regulation of mitotic cell cycle [GO:0007346]; regulation of timing of subpallium neuron differentiation [GO:0060165]; response to retinoic acid [GO:0032526]; spinal cord association neuron differentiation [GO:0021527]; spinal cord oligodendrocyte cell fate specification [GO:0021530]; stomach neuroendocrine cell differentiation [GO:0061102]; subpallium neuron fate commitment [GO:0060163]; sympathetic ganglion development [GO:0061549]; ventral spinal cord interneuron fate commitment [GO:0060579]; vestibular nucleus development [GO:0021750]" neuronal cell body [GO:0043025]; nucleus [GO:0005634] "bHLH transcription factor binding [GO:0043425]; chromatin binding [GO:0003682]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]" SAVEYIR 6.949999809 0 838.4049809 15.98699 14.39815 15.36953 14.7389 0 A0A8C0LZU7 A0A8C0LZU7_CANLF BHLH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DNA-binding transcription factor activity [GO:0003700]; protein dimerization activity [GO:0046983] SAAAGGPR 3.309999943 0.401669407 686.2543063 15.23616 15.86784 17.01293 16.19159 15.42648 A0A8C0TW54 A0A8C0TW54_CANLF BICD cargo adaptor 1 BICD1 Canis lupus familiaris (Dog) (Canis familiaris) minus-end-directed organelle transport along microtubule [GO:0072385]; positive regulation of protein localization to centrosome [GO:1904781]; positive regulation of receptor-mediated endocytosis [GO:0048260]; protein localization to organelle [GO:0033365]; regulation of microtubule cytoskeleton organization [GO:0070507]; viral process [GO:0016032] centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; secretory vesicle [GO:0099503]; trans-Golgi network [GO:0005802] cytoskeletal anchor activity [GO:0008093]; dynactin binding [GO:0034452]; dynein complex binding [GO:0070840]; dynein intermediate chain binding [GO:0045505]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267] AAARELAPMIDK 5.03000021 0.106265641 1301.309967 14.95312 16.32657 17.02509 16.23693 16.28382 A0A8C0NPB4 A0A8C0NPB4_CANLF BPI fold containing family B member 3 Canis lupus familiaris (Dog) (Canis familiaris) lipid binding [GO:0008289] MTLGITK 3.00999999 0.334338001 778.4108944 15.81457 15.31419 16.17446 14.62026 15.77364 A0A8C0PY04 A0A8C0PY04_CANLF BPL/LPL catalytic domain-containing protein HLCS Canis lupus familiaris (Dog) (Canis familiaris) protein modification process [GO:0036211] biotin-[acetyl-CoA-carboxylase] ligase activity [GO:0004077] NLIIPK 19.64999962 0.325729885 697.6220727 18.1331 15.9509 15.65051 17.54376 16.92032 A0A8C0PBA4 A0A8C0PBA4_CANLF BRCA2 DNA repair associated BRCA2 Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair via homologous recombination [GO:0000724] DNA binding [GO:0003677] GDALVSVGILK 17.63999939 0.280792736 1070.621516 16.74399 15.34529 11.43789 10.09327 15.74298 A0A8C0SQW2 A0A8C0SQW2_CANLF BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) BABAM1 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; hematopoietic stem cell proliferation [GO:0071425]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of DNA repair [GO:0045739]; response to ionizing radiation [GO:0010212] BRCA1-A complex [GO:0070531]; BRISC complex [GO:0070552]; cytosol [GO:0005829]; nuclear body [GO:0016604] VIICLDLSEEMSLSK 18.30999947 0.657461207 1737.552222 20.55403 19.97353 0 21.88067 20.53801 A0A8C0LXA7 A0A8C0LXA7_CANLF BTB domain-containing protein KCNC3 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] voltage-gated potassium channel complex [GO:0008076] voltage-gated potassium channel activity [GO:0005249] DVLGFLR 6.940000057 0.240198069 819.5108471 17.049 16.69945 17.63444 15.55095 15.73491 A0A8C0NMH6 A0A8C0NMH6_CANLF BTB domain-containing protein KLHL2 Canis lupus familiaris (Dog) (Canis familiaris) TPMNLPKLMVVVGGQAPK 3.140000105 0 1911.582721 0 16.47052 0 18.0829 15.22746 A0A8C0LYS6 A0A8C0LYS6_CANLF BTB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) VQAAGTDEVR 14.78999996 0.075156246 1045.789774 17.65366 18.66193 16.90102 21.45948 18.13538 A0A8C0SD15 A0A8C0SD15_CANLF BTB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) MSVSGKK 3.930000067 0.162522979 753.5855355 0 0 17.03426 16.17355 18.04872 A0A8C0P687 A0A8C0P687_CANLF BZIP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] LKVPNPK 9.93999958 0.002241565 795.1060951 15.39508 12.42987 15.55441 12.9719 16.92065 A0A8C0RAA1 A0A8C0RAA1_CANLF Beclin-1 BECN1 Canis lupus familiaris (Dog) (Canis familiaris) amyloid-beta metabolic process [GO:0050435]; apoptotic process [GO:0006915]; autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; cell division [GO:0051301]; cellular response to glucose starvation [GO:0042149]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; early endosome to late endosome transport [GO:0045022]; engulfment of apoptotic cell [GO:0043652]; lysosome organization [GO:0007040]; mitophagy [GO:0000423]; mitotic metaphase chromosome alignment [GO:0007080]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; neuron development [GO:0048666]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of autophagy [GO:0010508]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; protein-containing complex assembly [GO:0065003]; receptor catabolic process [GO:0032801]; regulation of cytokinesis [GO:0032465]; response to mitochondrial depolarisation [GO:0098780] "autophagosome [GO:0005776]; cytoplasmic side of mitochondrial outer membrane [GO:0032473]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; nuclear body [GO:0016604]; phagocytic vesicle [GO:0045335]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]; trans-Golgi network [GO:0005802]" GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; phosphatidylinositol 3-kinase binding [GO:0043548]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase binding [GO:0031625] ALKFMLTNLK 1.289999962 0.086798819 1177.978221 0 17.78978 16.64782 17.59632 18.4754 A0A8I3S1K5 A0A8I3S1K5_CANLF "Beta-1,4-galactosyltransferase (Beta-1,4-GalTase) (EC 2.4.1.-)" B4GALT1 Canis lupus familiaris (Dog) (Canis familiaris) acute inflammatory response [GO:0002526]; angiogenesis involved in wound healing [GO:0060055]; binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155]; development of secondary sexual characteristics [GO:0045136]; epithelial cell development [GO:0002064]; epithelial cell proliferation [GO:0050673]; extracellular matrix organization [GO:0030198]; galactose metabolic process [GO:0006012]; lactose biosynthetic process [GO:0005989]; lipid metabolic process [GO:0006629]; macrophage migration [GO:1905517]; negative regulation of epithelial cell proliferation [GO:0050680]; penetration of zona pellucida [GO:0007341]; positive regulation of apoptotic process [GO:0043065]; positive regulation of circulating fibrinogen levels [GO:0061755]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; protein N-linked glycosylation [GO:0006487]; regulation of acrosome reaction [GO:0060046] basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; desmosome [GO:0030057]; external side of plasma membrane [GO:0009897]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138]; protein-containing complex [GO:0032991] "beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831]; lactose synthase activity [GO:0004461]; manganese ion binding [GO:0030145]; N-acetyllactosamine synthase activity [GO:0003945]" CFSQPRHISVAMDK 9.479999542 0.489430265 1674.770741 21.21541 17.96114 18.50658 0 0 A0A8P0PBZ9 A0A8P0PBZ9_CANLF Beta-defensin DEFB128 Canis lupus familiaris (Dog) (Canis familiaris) defense response to bacterium [GO:0042742]; innate immune response [GO:0045087] extracellular region [GO:0005576] MGEIYEMACLNGK 6.949999809 0 1548.404363 15.13652 17.00096 14.16249 15.48324 15.92069 O18835 BGLR_CANLF Beta-glucuronidase (EC 3.2.1.31) GUSB Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; glucuronoside catabolic process [GO:0019391] extracellular space [GO:0005615]; lysosome [GO:0005764] beta-glucuronidase activity [GO:0004566]; carbohydrate binding [GO:0030246]; signaling receptor binding [GO:0005102] LANETGHHR 4.090000153 0 1034.309832 14.44641 13.72485 12.7097 13.21111 15.24659 A0A8C0RZL9 A0A8C0RZL9_CANLF Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (N-acetyl-beta-glucosaminidase subunit beta) Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate derivative metabolic process [GO:1901135]; carbohydrate metabolic process [GO:0005975] cortical granule [GO:0060473]; lysosome [GO:0005764] beta-N-acetylhexosaminidase activity [GO:0004563] DLGTHPGLR 2.829999924 0.365847244 965.0702717 15.3407 15.32392 17.87963 15.12871 16.44876 A0A8C0P0P4 A0A8C0P0P4_CANLF Beta/gamma crystallin 'Greek key' domain-containing protein CRYBG3 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate binding [GO:0030246]; structural constituent of eye lens [GO:0005212] LPAILEMKK 9.270000458 0.270829984 1059.434131 13.63922 15.57195 14.52301 15.65376 0 A0A8C0RN72 A0A8C0RN72_CANLF Bms1-type G domain-containing protein LOC119866554 Canis lupus familiaris (Dog) (Canis familiaris) ribosome biogenesis [GO:0042254] nucleolus [GO:0005730] GTP binding [GO:0005525] EELGGLFR 1.519999981 0.019982775 921.3734543 15.17079 14.86861 14.99409 12.59048 15.39765 A0A8I3NK03 A0A8I3NK03_CANLF Bone morphogenetic protein 5 BMP5 Canis lupus familiaris (Dog) (Canis familiaris) BMP signaling pathway [GO:0030509]; negative regulation of aldosterone biosynthetic process [GO:0032348]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cortisol biosynthetic process [GO:2000065]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; positive regulation of dendrite development [GO:1900006]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; type B pancreatic cell development [GO:0003323] extracellular region [GO:0005576] BMP receptor binding [GO:0070700]; growth factor activity [GO:0008083] HGPQSK 4.5 0.228312367 652.3307817 15.27249 16.57265 16.04173 16.13569 16.35708 A0A8C0MMS5 A0A8C0MMS5_CANLF Bromo domain-containing protein PHIP Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton organization [GO:0007010]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell morphogenesis [GO:0022604] nucleus [GO:0005634] lysine-acetylated histone binding [GO:0070577] EKPVKR 1.399999976 0.284519401 756.0360592 14.08385 15.63761 12.50047 15.81592 15.95543 A0A8C0Z276 A0A8C0Z276_CANLF Butyrophilin subfamily 1 member A1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EGWFVEGPEK 5.269999981 0.207668362 1177.350151 15.58236 13.10078 15.53697 0 14.00688 A0A8P0NLU2 A0A8P0NLU2_CANLF C-C motif chemokine CCL28 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615] chemokine activity [GO:0008009] DVQPRK 2.539999962 0 741.7154854 14.06447 7.530244 0 12.40405 11.40095 A0A8C0Q930 A0A8C0Q930_CANLF C-CAP/cofactor C-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) post-chaperonin tubulin folding pathway [GO:0007023] cytoplasm [GO:0005737] tubulin binding [GO:0015631] LQATLAERR 1.539999962 0.227521621 1057.273391 0 15.37566 13.91155 19.38225 15.8393 A0A8P0PJD9 A0A8P0PJD9_CANLF C-X-C motif chemokine LOC119874472 Canis lupus familiaris (Dog) (Canis familiaris) defense response [GO:0006952]; immune response [GO:0006955] extracellular space [GO:0005615] chemokine activity [GO:0008009] LLLLLLLLLGPAGR 1.799999952 0 1475.417126 18.56701 14.4918 14.76119 13.00755 12.02498 A0A8C0MYR4 A0A8C0MYR4_CANLF C-type lectin domain-containing protein FREM1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; cell communication [GO:0007154] membrane [GO:0016020] AEITMK 1.299999952 0.270677063 707.0524292 16.91197 16.60602 14.4457 19.94458 16.34906 A0A8C0NVJ6 A0A8C0NVJ6_CANLF C-type lectin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SFTSFSK 15.98999977 0.228437879 802.7376359 16.12707 15.91617 14.76239 0 16.09998 A0A8C0Q281 A0A8C0Q281_CANLF C1q domain-containing protein C1QTNF12 Canis lupus familiaris (Dog) (Canis familiaris) hormone activity [GO:0005179] VYLAARSR 5.900000095 0.233765452 936.1661924 15.39887 17.48504 15.82845 15.5263 16.33034 A0A8C0PLX2 A0A8C0PLX2_CANLF C2 domain-containing protein DYSF Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic vesicle membrane [GO:0030659]; plasma membrane [GO:0005886] metal ion binding [GO:0046872] MDVGTIYR 4.610000134 0.457571512 971.9748288 14.63298 16.13134 16.44752 15.56422 16.071 A0A8C0TPN0 A0A8C0TPN0_CANLF C2H2-type domain-containing protein ZNF276 Canis lupus familiaris (Dog) (Canis familiaris) GHAAPR 7.079999924 0.040938725 608.354478 16.01612 16.2981 14.93155 16.32932 17.55367 A0A8C0TIY7 A0A8C0TIY7_CANLF C2H2-type domain-containing protein ZNF276 Canis lupus familiaris (Dog) (Canis familiaris) MFSWELR 2.720000029 0.290798707 986.2615002 14.96107 13.32319 14.01782 17.27107 13.66923 A0A8I3PR19 A0A8I3PR19_CANLF C2H2-type domain-containing protein ZNF654 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] CMLCNK 3.980000019 0.110391345 842.2136111 14.98892 15.00907 14.57354 14.05012 15.80673 A0A8C0MZ04 A0A8C0MZ04_CANLF C2H2-type domain-containing protein ZNF674 Canis lupus familiaris (Dog) (Canis familiaris) SQECGGGGPAK 3.690000057 0.276991874 1045.979608 12.96819 14.58347 15.93976 15.13066 17.42123 A0A8C0RSC6 A0A8C0RSC6_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325] nucleus [GO:0005634] metal ion binding [GO:0046872] DPEIMT 1.200000048 0.186369897 721.6818777 16.90027 15.22484 16.70163 16.28298 16.50666 A0A8C0MHU0 A0A8C0MHU0_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GADLSE 2.329999924 0.404746628 591.0598749 17.64601 19.1263 16.24868 18.33014 18.51666 A0A8C0RWP2 A0A8C0RWP2_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GGPDTRR 7.820000172 0.341573081 758.8699201 14.99058 14.907 16.32401 15.05975 15.2199 A0A8C0PDR4 A0A8C0PDR4_CANLF C3H1-type domain-containing protein ZC3H13 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] metal ion binding [GO:0046872] TITPPLR 1.730000019 0 797.2109838 15.07919 14.7882 12.65028 16.0973 14.83 A0A8C0NJV5 A0A8C0NJV5_CANLF C3H1-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] metal ion binding [GO:0046872] AGAEGARGEGR 3.549999952 0.208362636 1030.258098 14.61589 14.38618 12.18592 13.7417 14.69126 A0A8C0QAB0 A0A8C0QAB0_CANLF CABIT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) KIMQFIK 8.369999886 0.26523905 922.8545748 15.86172 17.75212 15.69114 16.60021 17.11288 A0A8C0PR04 A0A8C0PR04_CANLF CAP-Gly domain-containing protein CEP350 Canis lupus familiaris (Dog) (Canis familiaris) microtubule anchoring [GO:0034453] centrosome [GO:0005813] microtubule binding [GO:0008017] DTVDSKDK 7.5 0.261039288 906.6090723 14.57965 12.10114 14.2381 13.58573 13.49428 A0A8C0PGD3 A0A8C0PGD3_CANLF CAP-Gly domain-containing protein CLIP1 Canis lupus familiaris (Dog) (Canis familiaris) TLVQEIEDLTTEKK 1.789999962 0 1645.994233 13.91838 0 14.90908 15.98061 0 A0A8C0M9R6 A0A8C0M9R6_CANLF CASK interacting protein 2 CASKIN2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] AQQRLEQTSSSLAAALR 6.139999866 2.49E-13 1830.625428 0 13.84582 15.49791 13.97746 13.73731 A0A8C0Z613 A0A8C0Z613_CANLF CCAAT-binding factor domain-containing protein CEBPZ Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] transcription coactivator activity [GO:0003713] KMLDPGLMMCSK 8.220000267 0.772387237 1427.36014 0 0 14.9051 0 17.38231 A0A8I3NHA5 A0A8I3NHA5_CANLF CD164 molecule CD164 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GASRVSSR 17.30999947 0.042090806 818.2710521 13.7492 0 14.18128 14.25536 14.96689 A0A8C0Z402 A0A8C0Z402_CANLF CD320 molecule Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ILSRGEAK 9.529999733 0.326127284 873.9480004 16.87 15.92066 12.97327 15.65809 15.71736 A0A8C0NTX5 A0A8C0NTX5_CANLF CD47 molecule CD47 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of inflammatory response [GO:0050729]; positive regulation of phagocytosis [GO:0050766] plasma membrane [GO:0005886] thrombospondin receptor activity [GO:0070053] GMMNDE 9.470000267 0.267510424 696.1959114 16.00434 15.5728 14.48687 16.69635 15.74334 A0A8C0QCZ9 A0A8C0QCZ9_CANLF CFA20 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ENICQIK 30.75 0.140442556 905.8841625 18.94687 19.86699 19.31364 23.65186 20.1367 A0A8I3P5N9 A0A8I3P5N9_CANLF CR-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein folding [GO:0006457] membrane [GO:0016020] Hsp70 protein binding [GO:0030544]; metal ion binding [GO:0046872]; unfolded protein binding [GO:0051082] VHIDKGMK 6.019999981 0.354270194 943.6651367 14.5426 14.46771 14.91677 13.56664 13.96881 A0A8C0PLM2 A0A8C0PLM2_CANLF CREB3 regulatory factor CREBRF Canis lupus familiaris (Dog) (Canis familiaris) response to unfolded protein [GO:0006986] nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AAAPVCSSK 4.519999981 0.24488008 891.3797804 15.71278 12.94289 16.05386 11.87849 17.65112 A0A8C0Q3Q0 A0A8C0Q3Q0_CANLF CUB domain-containing protein LRP10 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] SDLARSR 3.190000057 0.371624234 805.8092813 16.85499 17.11777 17.21501 20.16629 17.83966 A0A8C0PS81 A0A8C0PS81_CANLF CUB domain-containing protein LRP10 Canis lupus familiaris (Dog) (Canis familiaris) clathrin-coated pit [GO:0005905] CNYQTFCADGADER 10.68000031 0 1707.010208 0 17.23372 0 17.45366 14.84653 A0A8C0M636 A0A8C0M636_CANLF CXXC motif containing zinc binding protein Canis lupus familiaris (Dog) (Canis familiaris) GKIALQLK 2.299999952 0.323752812 870.247356 14.97602 15.731 15.47383 16.58857 14.59368 A0A8I3NPI3 A0A8I3NPI3_CANLF Cadherin 17 CDH17 Canis lupus familiaris (Dog) (Canis familiaris) calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; germinal center B cell differentiation [GO:0002314]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; integrin-mediated signaling pathway [GO:0007229]; marginal zone B cell differentiation [GO:0002315]; positive regulation of integrin activation by cell surface receptor linked signal transduction [GO:0033626]; spleen development [GO:0048536] basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cell surface [GO:0009986]; nucleoplasm [GO:0005654] calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; proton-dependent oligopeptide secondary active transmembrane transporter activity [GO:0005427] YEGSVR 1.830000043 0.279249484 711.0738312 15.0783 14.97409 13.88257 15.43206 14.70682 A0A8P0PN81 A0A8P0PN81_CANLF Cadherin domain-containing protein LOC487177 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] IWDQGI 7.349999905 0.251886824 730.3543666 16.69569 15.89269 15.11273 16.28063 15.71837 A0A8C0Z3E0 A0A8C0Z3E0_CANLF Cadherin-4 CDH4 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] FMQQAVR 10.35000038 0.185273556 894.4532896 12.11783 15.49984 13.45311 15.13657 16.3731 A0A8C0MYV3 A0A8C0MYV3_CANLF Calcium binding protein 5 CABP5 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] calcium ion binding [GO:0005509] DGFISCK 2.74000001 0 827.4090524 16.05165 0 0 13.98654 14.98637 A0A8C0NFX9 A0A8C0NFX9_CANLF Calcium dependent secretion activator 2 CADPS2 Canis lupus familiaris (Dog) (Canis familiaris) dense core granule exocytosis [GO:1990504]; protein transport [GO:0015031]; synaptic vesicle exocytosis [GO:0016079] cytoplasmic vesicle [GO:0031410]; presynapse [GO:0098793] LDHAFLFR 7.889999866 0.269025378 1018.625628 14.32063 11.69183 16.34688 15.48843 15.7832 A0A8I3P5X4 A0A8I3P5X4_CANLF Calcium-transporting ATPase (EC 7.2.2.10) ATP2A3 Canis lupus familiaris (Dog) (Canis familiaris) sarcoplasmic reticulum membrane [GO:0033017] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; P-type calcium transporter activity [GO:0005388] ERYGPNGK 1.899999976 0.394953299 919.594876 14.42943 15.10517 15.62634 16.63858 15.3184 A0A8I3SAK3 A0A8I3SAK3_CANLF Calmodulin regulated spectrin associated protein family member 3 CAMSAP3 Canis lupus familiaris (Dog) (Canis familiaris) cilium movement [GO:0003341]; epithelial cell-cell adhesion [GO:0090136]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment or maintenance of microtubule cytoskeleton polarity [GO:0030951]; in utero embryonic development [GO:0001701]; microtubule anchoring [GO:0034453]; neuron projection development [GO:0031175]; protein transport along microtubule [GO:0098840]; regulation of cell migration [GO:0030334]; regulation of focal adhesion assembly [GO:0051893]; regulation of Golgi organization [GO:1903358]; regulation of microtubule polymerization [GO:0031113]; zonula adherens maintenance [GO:0045218] axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; microtubule minus-end [GO:0036449]; motile cilium [GO:0031514]; zonula adherens [GO:0005915] actin filament binding [GO:0051015]; calmodulin binding [GO:0005516]; microtubule minus-end binding [GO:0051011]; spectrin binding [GO:0030507] ANHFLILFR 13.11999989 0.523907329 1131.764553 0 18.78849 18.80745 17.31414 20.08808 A0A8C0MM32 A0A8C0MM32_CANLF Carbonic anhydrase (EC 4.2.1.1) CA2 Canis lupus familiaris (Dog) (Canis familiaris) carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270] QINASFK 16.06999969 0.003984006 807.4322893 0 11.62328 14.43521 14.80397 15.83131 A0A8C0MT03 A0A8C0MT03_CANLF Carbonic anhydrase (EC 4.2.1.1) Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270] YAAELHLVHWNPK 6 0 1578.215117 15.81919 0 0 13.09452 16.08595 A0A8C0PH65 A0A8C0PH65_CANLF Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (EC 1.1.1.189) (EC 1.1.1.196) (EC 1.1.1.197) (EC 1.1.1.71) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (Prostaglandin 9-ketoreductase) (Prostaglandin-E(2) 9-reductase) Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" VALVTGANK 4.199999809 0.363610995 873.5095714 18.24058 17.83083 16.25257 17.83533 17.47794 A0A8C0MIE7 A0A8C0MIE7_CANLF Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) CPD Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] QVLIYLAR 4.070000172 0.085088578 975.665054 12.13267 13.75645 13.42937 14.69535 0 A0A8C0P3E6 A0A8C0P3E6_CANLF Carboxypeptidase Q (Plasma glutamate carboxypeptidase) CPQ Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764] carboxypeptidase activity [GO:0004180]; metallodipeptidase activity [GO:0070573] MSRCLGSTPEK 6 0.224686825 1282.035087 11.02905 13.73335 13.83696 12.29355 10.79047 A0A8C0NT01 A0A8C0NT01_CANLF "Carboxypeptidase X, M14 family member 2" CPXM2 CHST15 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular region [GO:0005576]; membrane [GO:0016020] metallocarboxypeptidase activity [GO:0004181]; sulfotransferase activity [GO:0008146]; zinc ion binding [GO:0008270] YGLGAHRGR 5.829999924 0.311921235 985.8061734 13.93827 14.24686 13.52872 14.41501 15.82595 P61012 PPLA_CANLF Cardiac phospholamban (PLB) PLN Canis lupus familiaris (Dog) (Canis familiaris) acrosome assembly [GO:0001675]; adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process [GO:0086023]; cardiac muscle tissue development [GO:0048738]; intracellular calcium ion homeostasis [GO:0006874]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901895]; negative regulation of calcium ion import into sarcoplasmic reticulum [GO:1902081]; negative regulation of calcium ion transmembrane transporter activity [GO:1901020]; negative regulation of heart rate [GO:0010459]; Notch signaling pathway [GO:0007219]; regulation of calcium ion import [GO:0090279]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of relaxation of muscle [GO:1901077]; regulation of the force of heart contraction by cardiac conduction [GO:0086092] calcium ion-transporting ATPase complex [GO:0090534]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017] ATPase inhibitor activity [GO:0042030]; protein homodimerization activity [GO:0042803] MDKVQYLTR 5.289999962 0.036927261 1168.387835 15.92975 13.57682 14.9964 12.19567 14.87579 A0A8C0S4S8 A0A8C0S4S8_CANLF Carnitine O-acetyltransferase CRAT Canis lupus familiaris (Dog) (Canis familiaris) "carnitine metabolic process, CoA-linked [GO:0019254]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; medium-chain fatty acid metabolic process [GO:0051791]; short-chain fatty acid metabolic process [GO:0046459]" mitochondrion [GO:0005739]; peroxisome [GO:0005777] acyl-CoA oxidase activity [GO:0003997]; carnitine O-acetyltransferase activity [GO:0004092] VSDDVYR 5.880000114 0.12802572 851.3021719 16.92341 16.73077 15.41692 15.78759 15.73307 A0A8C0SEA2 A0A8C0SEA2_CANLF Caspase 8 associated protein 2 CASP8AP2 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic signaling pathway [GO:0097190] nucleus [GO:0005634] DPSSSSPGIK 7.170000076 0.098993692 973.4449773 19.64918 17.82201 12.96848 16.84929 0 A0A8C0N9P3 A0A8C0N9P3_CANLF Caspase 9 CASP9 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981] cysteine-type endopeptidase activity [GO:0004197] RPRPPSWR 9.539999962 0.278854541 1051.229835 17.28095 14.75105 14.46953 13.88247 14.1602 Q9MZV7 CASP1_CANLF Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10] CASP1 IL1BC Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; positive regulation of cytokine production [GO:0001819]; positive regulation of interleukin-1 beta production [GO:0032731]; protein autoprocessing [GO:0016540]; pyroptosis [GO:0070269]; regulation of apoptotic process [GO:0042981]; regulation of inflammatory response [GO:0050727] AIM2 inflammasome complex [GO:0097169]; IPAF inflammasome complex [GO:0072557]; NLRP1 inflammasome complex [GO:0072558]; NLRP3 inflammasome complex [GO:0072559]; plasma membrane [GO:0005886] caspase binding [GO:0089720]; cysteine-type endopeptidase activity [GO:0004197] VLIDSVLRK 4.460000038 0.331988702 1042.953674 17.51234 17.29167 15.1939 0 16.81551 A0A8C0SQK1 A0A8C0SQK1_CANLF Catenin alpha 1 CTNNA1 Canis lupus familiaris (Dog) (Canis familiaris) apical junction assembly [GO:0043297]; cell motility [GO:0048870]; cellular response to indole-3-methanol [GO:0071681]; epithelial cell-cell adhesion [GO:0090136]; establishment or maintenance of cell polarity [GO:0007163]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of cell motility [GO:2000146]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of integrin-mediated signaling pathway [GO:2001045]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of protein localization to nucleus [GO:1900181]; neuroblast proliferation [GO:0007405]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of smoothened signaling pathway [GO:0045880]; protein localization [GO:0008104]; smoothened signaling pathway [GO:0007224] actin cytoskeleton [GO:0015629]; catenin complex [GO:0016342]; cytoplasm [GO:0005737]; flotillin complex [GO:0016600]; intercalated disc [GO:0014704]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; zonula adherens [GO:0005915] actin filament binding [GO:0051015]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; gamma-catenin binding [GO:0045295]; identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; vinculin binding [GO:0017166] QMCMIMMEMTDFTRGK 6.630000114 0 2058.585245 13.49696 14.37892 12.04961 12.55632 13.53017 A0A8I3PZ00 A0A8I3PZ00_CANLF Catenin beta like 1 CTNNBL1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of apoptotic process [GO:0043065]; somatic diversification of immunoglobulins [GO:0016445] centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681] enzyme binding [GO:0019899] MILTFEKR 2.670000076 0.248248099 1053.025293 15.70987 14.92034 17.68075 16.48115 14.1616 A0A8C0NM82 A0A8C0NM82_CANLF Cathepsin F Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] lysosome [GO:0005764] cysteine-type peptidase activity [GO:0008234] MASVFK 4.599999905 0 698.7225584 12.74042 6.627975 14.35052 10.69692 8.769324 A0A8C0MHN1 A0A8C0MHN1_CANLF Cathepsin propeptide inhibitor domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) QAKALNLGR 10.34000015 0 970.2157177 0 6.780766 15.47723 12.58124 0 A0A8C0LVL9 A0A8C0LVL9_CANLF Cation channel sperm associated auxiliary subunit beta CATSPERB Canis lupus familiaris (Dog) (Canis familiaris) CatSper complex [GO:0036128] TLEIPLLK 6.360000134 0.283857042 926.0653637 15.12969 16.13144 14.6212 15.24588 14.43769 A0A8C0RG08 A0A8C0RG08_CANLF Cell cycle regulator of NHEJ Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033] QSFAVR 6.889999866 0 707.2187862 7.48857 9.165995 13.53019 8.852454 10.89273 A0A8C0YW82 A0A8C0YW82_CANLF Cell division cycle 5 like CDC5L Canis lupus familiaris (Dog) (Canis familiaris) "DNA damage checkpoint signaling [GO:0000077]; mRNA splicing, via spliceosome [GO:0000398]" cytoplasm [GO:0005737]; DNA replication factor A complex [GO:0005662]; nuclear speck [GO:0016607]; Prp19 complex [GO:0000974]; U2-type catalytic step 2 spliceosome [GO:0071007] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; identical protein binding [GO:0042802]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; WD40-repeat domain binding [GO:0071987]" QQEREK 11.32999992 0.311118178 818.1593104 18.31859 17.65516 17.93012 16.66813 17.66604 A0A8C0LW74 A0A8C0LW74_CANLF Cellular retinoic acid-binding protein 2 CRABP2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] lipid binding [GO:0008289] MVCEQR 3.359999895 0.426987578 823.2168758 0 17.89547 0 15.10214 16.64372 A0A8C0NZK1 A0A8C0NZK1_CANLF Centriolar coiled-coil protein 110 CCP110 Canis lupus familiaris (Dog) (Canis familiaris) centriole replication [GO:0007099]; regulation of cytokinesis [GO:0032465] centriole [GO:0005814] AAEMGMPNKK 2.910000086 0.005661125 1075.830994 16.67176 16.2598 0 15.59457 0 A0A8C0N7Y0 A0A8C0N7Y0_CANLF Centromere protein U (MLF1-interacting protein) Canis lupus familiaris (Dog) (Canis familiaris) "chromosome, centromeric region [GO:0000775]; nucleus [GO:0005634]" LLDQKGDPTTK 4.53000021 0 1214.620827 0 0 0 17.3907 15.71168 A0A8I3PCI9 A0A8I3PCI9_CANLF Centrosomal protein 295 CEP295 Canis lupus familiaris (Dog) (Canis familiaris) centriole replication [GO:0007099]; positive regulation of centriole elongation [GO:1903724]; positive regulation of centrosome duplication [GO:0010825]; positive regulation of establishment of protein localization [GO:1904951]; positive regulation of protein acetylation [GO:1901985] centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; mitotic spindle microtubule [GO:1990498]; plasma membrane [GO:0005886] microtubule binding [GO:0008017] DPLRVSISR 14.38000011 0.236554758 1042.83781 0 15.92123 14.41986 16.38205 16.13358 A0A8C0MW63 A0A8C0MW63_CANLF Centrosomal protein POC5 (Protein of centriole 5) Canis lupus familiaris (Dog) (Canis familiaris) cell cycle [GO:0007049] centriole [GO:0005814]; cytoplasm [GO:0005737] ERIELMR 5.070000172 0.320130693 945.1468043 14.50739 14.28918 15.64988 13.83592 14.86571 A0A8C0N8S8 A0A8C0N8S8_CANLF Centrosomal protein of 70 kDa CEP70 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; regulation of microtubule cytoskeleton organization [GO:0070507] centrosome [GO:0005813]; cytoplasm [GO:0005737] gamma-tubulin binding [GO:0043015] LTKEDEER 5.050000191 0.268357709 1018.785828 13.34251 0 14.58312 18.35824 16.61846 A0A8C0NIK1 A0A8C0NIK1_CANLF Cerebral endothelial cell adhesion molecule CERCAM Canis lupus familiaris (Dog) (Canis familiaris) IISWSGSHK 5.920000076 0.164677961 1014.234156 15.0016 14.87826 12.51549 14.55631 14.65977 A0A8C0PX47 A0A8C0PX47_CANLF Chloride channel protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] voltage-gated chloride channel activity [GO:0005247] SSMGLVR 18.56999969 0.117311146 765.1436167 17.77019 15.62533 15.38807 16.77565 14.84821 A0A8C0NL98 A0A8C0NL98_CANLF Chordin like 2 CHRDL2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] KACVHSGK 3.789999962 0.030494164 885.2868525 15.78887 14.05064 12.76953 14.26617 14.85363 A0A8C0PQN4 A0A8C0PQN4_CANLF Chromatin assembly factor 1 subunit B C-terminal domain-containing protein CHAF1B Canis lupus familiaris (Dog) (Canis familiaris) DNA replication-dependent chromatin assembly [GO:0006335]; nucleosome assembly [GO:0006334] CAF-1 complex [GO:0033186]; chromatin [GO:0000785]; nucleoplasm [GO:0005654] EKPVLSMR 1.450000048 0.163154359 958.632919 14.67227 15.49252 13.70105 13.75978 14.80444 A0A8I3PP29 A0A8I3PP29_CANLF Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.12) (ATP-dependent helicase CHD8) CHD8 Canis lupus familiaris (Dog) (Canis familiaris) brain development [GO:0007420]; digestive tract development [GO:0048565]; in utero embryonic development [GO:0001701]; mRNA processing [GO:0006397]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; prepulse inhibition [GO:0060134]; social behavior [GO:0035176]; Wnt signaling pathway [GO:0016055] MLL1 complex [GO:0071339] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; hydrolase activity [GO:0016787]; methylated histone binding [GO:0035064]; p53 binding [GO:0002039] DEEGLK 4.369999886 0.264907822 690.7637415 0 13.07253 13.71634 15.42368 14.28437 A0A8I3MTJ0 A0A8I3MTJ0_CANLF Chromosome 11 open reading frame 71 C11orf71 Canis lupus familiaris (Dog) (Canis familiaris) AVNFVSLWAGVQRSR 3.980000019 0 1689.416412 20.64806 0 21.56874 21.7859 0 A0A8C0ND87 A0A8C0ND87_CANLF Chromosome 15 C16orf87 homolog C15H16orf87 Canis lupus familiaris (Dog) (Canis familiaris) GRPKTASAK 8.279999733 0.30634464 915.9414482 15.72083 12.96912 15.53762 15.78089 15.12026 A0A8C0NQL0 A0A8C0NQL0_CANLF Chromosome 18 C11orf80 homolog TOP6BL C18H11orf80 Canis lupus familiaris (Dog) (Canis familiaris) meiotic DNA double-strand break formation [GO:0042138] TLMTDSLVIKNFLHK 3.670000076 0.134712485 1775.801569 0 18.71209 0 16.41341 18.0516 A0A8C0MMW5 A0A8C0MMW5_CANLF Chromosome 24 C20orf96 homolog C24H20orf96 Canis lupus familiaris (Dog) (Canis familiaris) IENTYK 2.150000095 0.110420457 767.4153297 17.08165 17.27484 18.34109 16.39919 16.55547 A0A8C0N4K2 A0A8C0N4K2_CANLF Cilia and flagella associated protein 161 CFAP161 Canis lupus familiaris (Dog) (Canis familiaris) axonemal microtubule [GO:0005879] GLAAHR 4.230000019 0.433658797 624.6850461 21.34394 19.46999 16.7472 20.00019 19.19207 A0A8C0RKY9 A0A8C0RKY9_CANLF Cilia-and flagella-associated protein 96 C16H4orf47 Canis lupus familiaris (Dog) (Canis familiaris) centrosome [GO:0005813]; cytoplasm [GO:0005737] EKYEAPGK 12.06999969 0.353387616 919.9078265 14.64889 15.13039 16.26964 16.96291 15.365 A0A8I3MUT3 A0A8I3MUT3_CANLF Ciliogenesis and planar polarity effector complex subunit 1 CPLANE1 Canis lupus familiaris (Dog) (Canis familiaris) cerebellum development [GO:0021549]; cilium assembly [GO:0060271]; coronary vasculature development [GO:0060976]; embryonic digit morphogenesis [GO:0042733]; establishment of planar polarity [GO:0001736]; kidney development [GO:0001822]; protein localization to ciliary transition zone [GO:1904491]; roof of mouth development [GO:0060021]; ventricular septum development [GO:0003281] ciliary transition zone [GO:0035869] ILLLFR 31.61000061 0.413919705 775.1271966 16.60817 15.33112 16.92191 15.98922 15.31349 A0A8C0RTB8 A0A8C0RTB8_CANLF Clathrin heavy chain linker domain-containing protein 1 Canis lupus familiaris (Dog) (Canis familiaris) DLAENMNK 2.369999886 0.352385093 950.3452149 14.83831 0 13.67493 15.39123 13.77306 A0A8C0TGB7 A0A8C0TGB7_CANLF Coiled-coil domain containing 105 CCDC105 Canis lupus familiaris (Dog) (Canis familiaris) DTLLEMAK 5.75 0.227645188 920.1018862 10.66305 6.545496 0 11.42981 15.42455 A0A8C0NGE6 A0A8C0NGE6_CANLF Coiled-coil domain containing 14 CCDC14 Canis lupus familiaris (Dog) (Canis familiaris) HVPSGVRK 2.50999999 0.188231839 879.9598757 14.21538 14.84394 14.69722 14.00098 15.86818 A0A8C0P086 A0A8C0P086_CANLF Coiled-coil domain containing 150 CCDC150 Canis lupus familiaris (Dog) (Canis familiaris) DVKEDEDK 5.110000134 1.22E-13 977.0139812 13.738 14.56695 16.74473 14.6751 14.46684 A0A8C0SM18 A0A8C0SM18_CANLF Coiled-coil domain containing 177 Canis lupus familiaris (Dog) (Canis familiaris) ARHEALLQGR 9.329999924 0 1150.02245 14.18062 0 14.31587 0 13.0028 A0A8C0MU15 A0A8C0MU15_CANLF Coiled-coil domain containing 18 CCDC18 Canis lupus familiaris (Dog) (Canis familiaris) VDLLEQSK 17.63999939 0.214526192 931.5894934 16.5995 17.00301 18.75317 18.75599 18.74807 A0A8C0NSB3 A0A8C0NSB3_CANLF Coiled-coil domain containing 188 CCDC188 Canis lupus familiaris (Dog) (Canis familiaris) EQGAPR 4.980000019 0.299081629 658.0131721 16.59715 15.18771 15.9734 0 16.12799 A0A8C0N7H3 A0A8C0N7H3_CANLF Coiled-coil domain containing 33 CCDC33 Canis lupus familiaris (Dog) (Canis familiaris) EKQDLATR 4.079999924 0.056366551 960.6134368 13.54836 14.47471 13.92587 10.70362 14.40786 A0A8I3P054 A0A8I3P054_CANLF Coiled-coil domain containing 40 CCDC40 Canis lupus familiaris (Dog) (Canis familiaris) determination of digestive tract left/right asymmetry [GO:0071907]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; flagellated sperm motility [GO:0030317]; heart looping [GO:0001947]; inner dynein arm assembly [GO:0036159]; lung development [GO:0030324]; motile cilium assembly [GO:0044458]; regulation of cilium beat frequency [GO:0003356] axoneme [GO:0005930]; extracellular region [GO:0005576] LQPSGPP 3.279999971 0.3262788 693.9485714 18.48051 16.53993 17.49269 17.38163 16.47693 A0A8C0QKJ0 A0A8C0QKJ0_CANLF Coiled-coil domain containing 69 CCDC69 Canis lupus familiaris (Dog) (Canis familiaris) spindle midzone assembly [GO:0051255] cytoplasm [GO:0005737]; spindle midzone [GO:0051233] NLMLEEK 5.389999866 0.359548116 892.876135 16.13923 14.58972 0 0 14.55472 A0A8C0NXH0 A0A8C0NXH0_CANLF Coiled-coil domain containing 73 CCDC73 Canis lupus familiaris (Dog) (Canis familiaris) DAVQGQK 3.539999962 0.040590414 745.3050725 15.41773 15.61276 14.19046 14.16959 15.15763 A0A8I3NQW1 A0A8I3NQW1_CANLF Coiled-coil domain containing 88C CCDC88C Canis lupus familiaris (Dog) (Canis familiaris) apical constriction [GO:0003383]; cytoskeleton-dependent intracellular transport [GO:0030705]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; non-canonical Wnt signaling pathway [GO:0035567]; protein destabilization [GO:0031648]; regulation of protein phosphorylation [GO:0001932]; small GTPase mediated signal transduction [GO:0007264]; stress-activated protein kinase signaling cascade [GO:0031098] cell junction [GO:0030054]; cytoplasm [GO:0005737] frizzled binding [GO:0005109]; G-protein alpha-subunit binding [GO:0001965]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; PDZ domain binding [GO:0030165]; protein self-association [GO:0043621] LDNHCELLSRLK 8.010000229 0 1497.013647 15.56922 10.39753 0 14.7594 16.65904 A0A8C0M460 A0A8C0M460_CANLF Coiled-coil serine rich protein 2 CCSER2 Canis lupus familiaris (Dog) (Canis familiaris) MNRFDR 15 0.356721317 854.2796529 16.7873 15.53384 17.03987 16.35138 17.40417 A0A8C0P1X4 A0A8C0P1X4_CANLF Collagen IV NC1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) basement membrane [GO:0005604]; collagen trimer [GO:0005581]; membrane [GO:0016020] extracellular matrix structural constituent [GO:0005201] AGQLHTR 7.519999981 0.218320963 782.8902617 0 13.90493 13.03727 12.61189 14.28948 A0A8I3NKN2 A0A8I3NKN2_CANLF Collagen triple helix repeat containing 1 CTHRC1 Canis lupus familiaris (Dog) (Canis familiaris) "cochlea morphogenesis [GO:0090103]; establishment of planar polarity involved in neural tube closure [GO:0090177]; inner ear receptor cell stereocilium organization [GO:0060122]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; ossification involved in bone remodeling [GO:0043932]; osteoblast differentiation [GO:0001649]; osteoblast proliferation [GO:0033687]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoblast proliferation [GO:0033690]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" extracellular space [GO:0005615]; sarcoplasm [GO:0016528] frizzled binding [GO:0005109]; Wnt-protein binding [GO:0017147] VLFSGSLR 6.300000191 0.385678643 879.8196212 18.01766 16.1043 17.77311 15.35657 15.23972 A0A8C0PFU8 A0A8C0PFU8_CANLF Collagen type II alpha 1 chain COL2A1 Canis lupus familiaris (Dog) (Canis familiaris) anterior head development [GO:0097065]; cartilage condensation [GO:0001502]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cellular response to BMP stimulus [GO:0071773]; central nervous system development [GO:0007417]; chondrocyte differentiation [GO:0002062]; collagen fibril organization [GO:0030199]; embryonic skeletal joint morphogenesis [GO:0060272]; endochondral ossification [GO:0001958]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; heart morphogenesis [GO:0003007]; inner ear morphogenesis [GO:0042472]; limb bud formation [GO:0060174]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; notochord development [GO:0030903]; otic vesicle development [GO:0071599]; proteoglycan metabolic process [GO:0006029]; regulation of gene expression [GO:0010468]; roof of mouth development [GO:0060021]; sensory perception of sound [GO:0007605]; tissue homeostasis [GO:0001894]; visual perception [GO:0007601] basement membrane [GO:0005604]; collagen type II trimer [GO:0005585]; cytoplasm [GO:0005737]; extracellular space [GO:0005615] extracellular matrix structural constituent [GO:0005201]; metal ion binding [GO:0046872]; MHC class II protein binding [GO:0042289]; platelet-derived growth factor binding [GO:0048407]; protein homodimerization activity [GO:0042803]; proteoglycan binding [GO:0043394] ADQAAGDLR 11.15999985 0.344793385 916.3915739 19.90137 16.88003 14.81183 17.90232 13.55823 A0A8I3S0U4 A0A8I3S0U4_CANLF Collagen type IV alpha 1 chain COL4A1 Canis lupus familiaris (Dog) (Canis familiaris) basement membrane organization [GO:0071711]; brain development [GO:0007420]; branching involved in blood vessel morphogenesis [GO:0001569]; cellular response to amino acid stimulus [GO:0071230]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; neuromuscular junction development [GO:0007528]; renal tubule morphogenesis [GO:0061333]; retinal blood vessel morphogenesis [GO:0061304] collagen type IV trimer [GO:0005587]; membrane [GO:0016020] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; platelet-derived growth factor binding [GO:0048407] VDMGSMK 9.210000038 0.237083777 798.7211588 15.19748 13.81453 15.02822 16.58436 14.45892 A0A8I3MMP3 A0A8I3MMP3_CANLF Collapsin response mediator protein 1 CRMP1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of neuron projection development [GO:0010977] centrosome [GO:0005813]; cytosol [GO:0005829]; midbody [GO:0030496] "filamin binding [GO:0031005]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810]; identical protein binding [GO:0042802]" GGPQMR 1.929999948 0.292420781 661.279007 0 16.41037 16.93054 18.8497 16.47977 A0A8I3NQA0 A0A8I3NQA0_CANLF Complement C3 C3 Canis lupus familiaris (Dog) (Canis familiaris) "amyloid-beta clearance [GO:0097242]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; complement receptor mediated signaling pathway [GO:0002430]; complement-dependent cytotoxicity [GO:0097278]; complement-mediated synapse pruning [GO:0150062]; inflammatory response [GO:0006954]; neuron remodeling [GO:0016322]; oviduct epithelium development [GO:0035846]; positive regulation of activation of membrane attack complex [GO:0001970]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic cell clearance [GO:2000427]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of glucose transmembrane transport [GO:0010828]; positive regulation of lipid storage [GO:0010884]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of type IIa hypersensitivity [GO:0001798]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of triglyceride biosynthetic process [GO:0010866]; response to bacterium [GO:0009617]; vertebrate eye-specific patterning [GO:0150064]" cell surface [GO:0009986]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991] C5L2 anaphylatoxin chemotactic receptor binding [GO:0031715]; endopeptidase inhibitor activity [GO:0004866] VGLIQPGSVK 37.81000137 0 997.8229648 0 15.91654 0 15.2015 16.52132 A0A8C0MWH9 A0A8C0MWH9_CANLF Copine 7 CPNE7 Canis lupus familiaris (Dog) (Canis familiaris) calcium-dependent phospholipid binding [GO:0005544] CVLAEVPR 3.109999895 0.301051934 942.9074642 19.21422 20.16819 0 20.76771 18.03509 A0A8C0RJZ6 A0A8C0RJZ6_CANLF Cortactin-binding protein-2 N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RPRPPPTAAPARPPVPR 3.619999886 0.166156299 1833.320222 15.07493 12.57509 13.56863 0 15.25419 A0A8C0RF90 A0A8C0RF90_CANLF Corticotropin releasing hormone receptor 2 CRHR2 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] RGLSGAGSAR 14.94999981 0.071627345 931.4400088 15.37769 13.66308 14.27962 15.38483 16.49609 A0A8I3PE50 A0A8I3PE50_CANLF Cullin 4B CUL4B Canis lupus familiaris (Dog) (Canis familiaris) astrocyte differentiation [GO:0048708]; gene expression [GO:0010467]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of protein catabolic process [GO:0045732]; proteasomal protein catabolic process [GO:0010498]; protein polyubiquitination [GO:0000209]; ribosome biogenesis [GO:0042254]; ubiquitin-dependent protein catabolic process [GO:0006511]; UV-damage excision repair [GO:0070914] Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] damaged DNA binding [GO:0003684]; ubiquitin protein ligase binding [GO:0031625] IESLIDRDYMER 9.270000458 0.004182194 1539.222003 14.31074 10.43688 10.38002 16.05036 0 A0A8C0SQA3 A0A8C0SQA3_CANLF Cyclic nucleotide-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion channel complex [GO:0034702] voltage-gated potassium channel activity [GO:0005249] KDASSFR 6.5 0.411257999 809.9161216 16.73783 16.15554 18.13698 14.68928 15.62727 A0A8C0PA73 A0A8C0PA73_CANLF Cyclin-D1-binding protein 1 Canis lupus familiaris (Dog) (Canis familiaris) cell cycle [GO:0007049]; regulation of cell cycle [GO:0051726] cytoplasm [GO:0005737]; nucleus [GO:0005634] ASKACLK 1.059999943 0.278369709 777.3118397 15.19996 15.7816 16.3678 14.2042 15.18848 A0A8C0P1C1 A0A8C0P1C1_CANLF Cyclin-like domain-containing protein CCNT2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] TEQIYSQK 11.82999992 0.040525609 997.1598269 13.72321 12.90328 14.55893 14.42035 14.55701 A0A8C0QCS8 A0A8C0QCS8_CANLF Cystic fibrosis transmembrane conductance regulator (EC 5.6.1.6) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (cAMP-dependent chloride channel) CFTR Canis lupus familiaris (Dog) (Canis familiaris) amelogenesis [GO:0097186]; cellular response to cAMP [GO:0071320]; cellular response to forskolin [GO:1904322]; cholesterol biosynthetic process [GO:0006695]; cholesterol transport [GO:0030301]; establishment of localization in cell [GO:0051649]; intracellular pH elevation [GO:0051454]; membrane hyperpolarization [GO:0060081]; multicellular organismal-level water homeostasis [GO:0050891]; positive regulation of enamel mineralization [GO:0070175]; positive regulation of exocytosis [GO:0045921]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; response to endoplasmic reticulum stress [GO:0034976]; sperm capacitation [GO:0048240]; transepithelial water transport [GO:0035377]; vesicle docking involved in exocytosis [GO:0006904] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; chloride channel complex [GO:0034707]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; recycling endosome membrane [GO:0055038] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride channel inhibitor activity [GO:0019869]; enzyme binding [GO:0019899]; intracellularly ATP-gated chloride channel activity [GO:0005260]; isomerase activity [GO:0016853]; PDZ domain binding [GO:0030165]; protein-folding chaperone binding [GO:0051087]; Sec61 translocon complex binding [GO:0106138] EDDIWPSGGQMTVK 8.069999695 0.023843546 1579.425394 16.35091 13.68133 0 0 13.64747 A0A8C0PD20 A0A8C0PD20_CANLF Cytochrome P450 3A (EC 1.14.14.-) Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" MSVPGSVLSR 4.840000153 0 1048.404143 15.244 13.52183 14.43718 13.99215 12.36427 A0A8C0SNY1 A0A8C0SNY1_CANLF Cytochrome P450 4A38 CYP4A38 Canis lupus familiaris (Dog) (Canis familiaris) intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" LENTADRSGGR 2.869999886 0.126507812 1175.261462 15.68384 14.15532 13.34981 11.62998 12.88684 A0A8C0MQC5 A0A8C0MQC5_CANLF Cytochrome P450 family 27 subfamily A member 1 CYP27A1 Canis lupus familiaris (Dog) (Canis familiaris) organic hydroxy compound metabolic process [GO:1901615]; steroid biosynthetic process [GO:0006694] endoplasmic reticulum [GO:0005783]; mitochondrial inner membrane [GO:0005743] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" MDRLAALR 7.400000095 0.439968927 962.0549221 14.66588 16.06285 0 17.04681 15.58797 A0A8C0MFC2 A0A8C0MFC2_CANLF Cytochrome P450 family 39 subfamily A member 1 Canis lupus familiaris (Dog) (Canis familiaris) organic hydroxy compound metabolic process [GO:1901615]; steroid metabolic process [GO:0008202] intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" ISNIMVFK 2.559999943 0.325514645 952.2484346 15.2313 14.91262 17.5738 11.23744 14.82799 A0A8I3PYS9 A0A8I3PYS9_CANLF Cytochrome b5 domain-containing protein 1 CYB5D1 Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] metal ion binding [GO:0046872] MADSAGAMQR 1.50999999 0.032695098 1053.336737 14.59816 0 15.91255 15.47581 0 A0A8C0SQV9 A0A8C0SQV9_CANLF Cytochrome c oxidase assembly factor 4 homolog CHCHD8 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial cytochrome c oxidase assembly [GO:0033617] mitochondrial intermembrane space [GO:0005758] EQGSAHH 4.179999828 0.282587034 764.9130364 15.29803 0 14.85288 16.2225 14.58254 A0A8C0RJK2 A0A8C0RJK2_CANLF Cytochrome c oxidase assembly factor 7 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial intermembrane space [GO:0005758] NVQPLTFG 5.599999905 0.304622919 875.2428674 15.85426 15.00422 14.43349 14.09171 14.79115 A0A8C0PSC8 A0A8C0PSC8_CANLF Cytoplasmic tRNA 2-thiolation protein 1 (EC 2.7.7.-) (ATP-binding domain-containing protein 3) (Cytoplasmic tRNA adenylyltransferase 1) CTU1 ATPBD3 NCS6 Canis lupus familiaris (Dog) (Canis familiaris) protein urmylation [GO:0032447]; tRNA thio-modification [GO:0034227]; tRNA wobble uridine modification [GO:0002098] cytoplasm [GO:0005737] ATP binding [GO:0005524]; nucleotidyltransferase activity [GO:0016779]; tRNA binding [GO:0000049] AALRRPR 1.909999967 0.070244093 840.3329752 16.06523 15.84439 15.16604 13.85425 16.6065 A0A8C0PGX2 A0A8C0PGX2_CANLF D-aminoacyl-tRNA deacylase (EC 3.1.1.96) DTD1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] D-aminoacyl-tRNA deacylase activity [GO:0051499]; tRNA binding [GO:0000049] ELEHMVR 7.5 1.22E-13 912.4048579 0 14.31353 0 0 0 A0A8C0PEV6 A0A8C0PEV6_CANLF "D-beta-hydroxybutyrate dehydrogenase, mitochondrial (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase)" BDH1 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] mitochondrial inner membrane [GO:0005743] "oxidoreductase activity, acting on CH-OH group of donors [GO:0016614]" GAPLLPGSRR 2.369999886 0.293901927 1022.794988 13.61007 15.02669 15.87149 15.41489 14.51457 A0A8C0YWX2 A0A8C0YWX2_CANLF D-lactate dehydrogenase (cytochrome) (EC 1.1.2.4) LDHD Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] catalytic activity [GO:0003824]; FAD binding [GO:0071949] LPEILVQTK 14.84000015 0.060146595 1040.778291 16.94288 17.98616 15.99143 19.26611 17.73944 A0A8C0NFL3 A0A8C0NFL3_CANLF DCN1-like protein (Defective in cullin neddylation protein 1-like protein) Canis lupus familiaris (Dog) (Canis familiaris) GGPSPARR 5.28000021 0.466986062 799.0759763 13.83253 14.73773 0 15.11221 15.66207 A0A8C0N2J4 A0A8C0N2J4_CANLF DDB1- and CUL4-associated factor 11 DCAF11 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] STPFLR 5.079999924 0.311990759 721.1548996 16.86788 16.63026 14.77051 16.05719 17.1797 A0A8C0P6F2 A0A8C0P6F2_CANLF DDHD domain-containing protein PITPNM1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; phospholipid transporter activity [GO:0005548] TAAQTGPLMCAYKLCK 6.239999771 0 1812.62011 17.42372 16.27526 15.41598 0 0 A0A8C0MM69 A0A8C0MM69_CANLF DENN domain containing 4C Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085] KCFGAPLI 8.149999619 0.355345156 906.3101964 14.8893 15.85899 13.5778 15.04891 15.09079 A0A8C0PQQ2 A0A8C0PQQ2_CANLF "DEP domain containing 5, GATOR1 subcomplex subunit" DEPDC5 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to amino acid starvation [GO:0034198]; intracellular signal transduction [GO:0035556]; negative regulation of TORC1 signaling [GO:1904262] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; GATOR1 complex [GO:1990130]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471] GTPase activator activity [GO:0005096]; protein-containing complex binding [GO:0044877]; small GTPase binding [GO:0031267] ALPTEEVR 4.139999866 0.372189711 915.8086828 9.938061 14.4353 15.04325 0 13.52473 A0A8C0MRS9 A0A8C0MRS9_CANLF DLG associated protein 1 DLGAP1 Canis lupus familiaris (Dog) (Canis familiaris) signaling [GO:0023052] QMDPLDK 5.21999979 0.374754665 846.2238679 16.46935 14.16094 16.32246 15.95008 15.8471 A0A8C0RVJ3 A0A8C0RVJ3_CANLF DLG associated protein 5 DLGAP5 Canis lupus familiaris (Dog) (Canis familiaris) signaling [GO:0023052] cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; spindle pole centrosome [GO:0031616] TAVGQTR 1.399999976 0.345641629 731.5626412 17.14597 15.70763 15.84467 18.74644 15.85328 A0A8C0MAP0 A0A8C0MAP0_CANLF DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37) DNMT3A Canis lupus familiaris (Dog) (Canis familiaris) autosome genomic imprinting [GO:0141068]; cellular response to amino acid stimulus [GO:0071230]; cellular response to bisphenol A [GO:1903926]; DNA methylation-dependent heterochromatin formation [GO:0006346]; negative regulation of transcription by RNA polymerase II [GO:0000122]; post-fertilization epigenetic regulation of gene expression [GO:0043045]; spermatogenesis [GO:0007283] "catalytic complex [GO:1902494]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; XY body [GO:0001741]" chromatin binding [GO:0003682]; DNA (cytosine-5-)-methyltransferase activity [GO:0003886]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-cysteine methyltransferase activity [GO:0106363]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] HPPVESSDTPK 3.99000001 0.281150958 1193.899943 15.57925 16.00242 12.80433 11.65658 12.57608 A0A8C0PYP0 A0A8C0PYP0_CANLF DNA damage-binding protein 2 (Damage-specific DNA-binding protein 2) DDB2 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; nucleus [GO:0005634] damaged DNA binding [GO:0003684] AAAVNHR 1.639999986 0 738.4056511 19.89027 15.35949 18.32395 17.72301 15.95552 A0A8C0MP97 A0A8C0MP97_CANLF DNA helicase (EC 3.6.4.12) CHD6 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; hydrolase activity [GO:0016787] LIAGGHK 6.230000019 0.392967674 692.7283322 16.58734 16.52001 14.99203 17.67318 16.48494 A0A8C0SYB8 A0A8C0SYB8_CANLF DNA helicase (EC 3.6.4.12) CHD7 Canis lupus familiaris (Dog) (Canis familiaris) adult heart development [GO:0007512]; adult walking behavior [GO:0007628]; aorta morphogenesis [GO:0035909]; atrioventricular canal development [GO:0036302]; blood circulation [GO:0008015]; blood vessel remodeling [GO:0001974]; cardiac septum morphogenesis [GO:0060411]; cognition [GO:0050890]; embryonic hindlimb morphogenesis [GO:0035116]; epithelium development [GO:0060429]; face development [GO:0060324]; female genitalia development [GO:0030540]; in utero embryonic development [GO:0001701]; innervation [GO:0060384]; nose development [GO:0043584]; olfactory behavior [GO:0042048]; olfactory bulb development [GO:0021772]; olfactory nerve development [GO:0021553]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of growth hormone secretion [GO:0060123]; regulation of neurogenesis [GO:0050767]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; response to bacterium [GO:0009617]; retina development in camera-type eye [GO:0060041]; right ventricular compact myocardium morphogenesis [GO:0003226]; secondary palate development [GO:0062009]; semicircular canal morphogenesis [GO:0048752]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; T cell differentiation [GO:0030217]; transcription by RNA polymerase II [GO:0006366]; ventricular trabecula myocardium morphogenesis [GO:0003222] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; hydrolase activity [GO:0016787]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] IPKEPK 2.880000114 0.239423877 710.9918522 17.03551 17.65226 16.01841 18.71713 16.19566 A0A8I3RYL3 A0A8I3RYL3_CANLF DNA helicase (EC 3.6.4.12) RECQL4 Canis lupus familiaris (Dog) (Canis familiaris) DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA replication [GO:0006260]; telomeric D-loop disassembly [GO:0061820] "chromosome, telomeric region [GO:0000781]; nucleoplasm [GO:0005654]" ATP binding [GO:0005524]; bubble DNA binding [GO:0000405]; DNA/DNA annealing activity [GO:1990814]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; oxidized purine DNA binding [GO:0032357]; telomeric D-loop binding [GO:0061821]; zinc ion binding [GO:0008270] STARDVAR 3.170000076 0.334176947 875.7051264 19.05199 15.64861 14.67274 16.62024 15.42793 A0A8C0SBJ9 A0A8C0SBJ9_CANLF DNA mismatch repair protein MSH2 Canis lupus familiaris (Dog) (Canis familiaris) B cell differentiation [GO:0030183]; determination of adult lifespan [GO:0008340]; double-strand break repair [GO:0006302]; germ cell development [GO:0007281]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; isotype switching [GO:0045190]; maintenance of DNA repeat elements [GO:0043570]; male gonad development [GO:0008584]; mismatch repair [GO:0006298]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; negative regulation of DNA recombination [GO:0045910]; negative regulation of neuron apoptotic process [GO:0043524]; oxidative phosphorylation [GO:0006119]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; postreplication repair [GO:0006301]; protein localization to chromatin [GO:0071168]; response to UV-B [GO:0010224]; response to X-ray [GO:0010165]; somatic hypermutation of immunoglobulin genes [GO:0016446] MutSalpha complex [GO:0032301]; MutSbeta complex [GO:0032302]; nucleoplasm [GO:0005654] ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; centromeric DNA binding [GO:0019237]; chromatin binding [GO:0003682]; dinucleotide repeat insertion binding [GO:0032181]; four-way junction DNA binding [GO:0000400]; guanine/thymine mispair binding [GO:0032137]; magnesium ion binding [GO:0000287]; MutLalpha complex binding [GO:0032405]; oxidized purine DNA binding [GO:0032357]; protein homodimerization activity [GO:0042803]; single guanine insertion binding [GO:0032142]; single thymine insertion binding [GO:0032143]; single-stranded DNA binding [GO:0003697] QSLQEDLLR 1.289999962 0.024373175 1100.953903 14.83611 11.36566 15.16293 15.37809 14.76158 A0A8C0T9R5 A0A8C0T9R5_CANLF DNA polymerase alpha subunit B POLA2 Canis lupus familiaris (Dog) (Canis familiaris) "DNA replication initiation [GO:0006270]; DNA replication, synthesis of RNA primer [GO:0006269]; protein import into nucleus [GO:0006606]" alpha DNA polymerase:primase complex [GO:0005658]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] DNA binding [GO:0003677] MQATAAGPETR 4.869999886 0.237701833 1148.62804 14.23093 14.54687 17.51426 15.36298 0 A0A8C0N8C3 A0A8C0N8C3_CANLF DNA polymerase eta Canis lupus familiaris (Dog) (Canis familiaris) DNA biosynthetic process [GO:0071897]; postreplication repair [GO:0006301] nucleus [GO:0005634] damaged DNA binding [GO:0003684]; metal ion binding [GO:0046872]; transferase activity [GO:0016740] AFGVTR 5.670000076 0.282742915 649.2406343 17.53147 15.01405 16.20345 15.71865 14.46939 A0A8C0MAV5 A0A8C0MAV5_CANLF DNA polymerase zeta catalytic subunit (EC 2.7.7.7) REV3L Canis lupus familiaris (Dog) (Canis familiaris) translesion synthesis [GO:0019985] nuclear lumen [GO:0031981]; zeta DNA polymerase complex [GO:0016035] DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166] TDLYRWK 1.580000043 0.319711041 981.3536623 17.45002 15.38733 17.30863 16.32652 15.22756 A0A8C0NTP3 A0A8C0NTP3_CANLF DNA replication licensing factor MCM7 (EC 3.6.4.12) MCM7 Canis lupus familiaris (Dog) (Canis familiaris) cell cycle [GO:0007049]; DNA replication initiation [GO:0006270] chromosome [GO:0005694]; MCM complex [GO:0042555]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678] DSLLGDK 4.480000019 0.254533366 747.9443859 17.30989 12.82868 16.39457 16.6701 15.3548 A0A8I3N3P1 A0A8I3N3P1_CANLF DNA topoisomerase 2 (EC 5.6.2.2) TOP2A Canis lupus familiaris (Dog) (Canis familiaris) apoptotic chromosome condensation [GO:0030263]; chromosome segregation [GO:0007059]; DNA damage response [GO:0006974]; DNA ligation [GO:0006266]; DNA topological change [GO:0006265]; embryonic cleavage [GO:0040016]; female meiotic nuclear division [GO:0007143]; hematopoietic progenitor cell differentiation [GO:0002244]; negative regulation of DNA duplex unwinding [GO:1905463]; positive regulation of apoptotic process [GO:0043065]; positive regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045870]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; rhythmic process [GO:0048511] "centriole [GO:0005814]; chromosome, centromeric region [GO:0000775]; condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex [GO:0009330]; male germ cell nucleus [GO:0001673]; nuclear chromosome [GO:0000228]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]" "ATP binding [GO:0005524]; chromatin binding [GO:0003682]; DNA binding, bending [GO:0008301]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO:0003918]; magnesium ion binding [GO:0000287]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase C binding [GO:0005080]; ubiquitin binding [GO:0043130]" EWLLGMLGAESAK 3.880000114 0 1421.826274 0 0 14.67198 17.24285 14.4558 A0A8C0TJ21 A0A8C0TJ21_CANLF DNA topoisomerase II binding protein 1 TOPBP1 Canis lupus familiaris (Dog) (Canis familiaris) chromosome organization [GO:0051276]; DNA damage checkpoint signaling [GO:0000077]; DNA replication checkpoint signaling [GO:0000076]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; double-strand break repair via homologous recombination [GO:0000724]; protein localization to site of double-strand break [GO:1990166]; response to ionizing radiation [GO:0010212] actin cytoskeleton [GO:0015629]; BRCA1-B complex [GO:0070532]; condensed nuclear chromosome [GO:0000794]; male germ cell nucleus [GO:0001673]; plasma membrane [GO:0005886]; PML body [GO:0016605]; site of double-strand break [GO:0035861] chromatin-protein adaptor activity [GO:0140463]; identical protein binding [GO:0042802]; phosphorylation-dependent protein binding [GO:0140031]; protein serine/threonine kinase activator activity [GO:0043539] ESATSNGDGR 1.169999957 0.356053077 992.632569 14.18856 16.03647 15.90728 13.19722 15.23637 A0A8C0MHT1 A0A8C0MHT1_CANLF DNA-(apurinic or apyrimidinic site) endonuclease (EC 3.1.-.-) APEX1 Canis lupus familiaris (Dog) (Canis familiaris) DNA recombination [GO:0006310]; DNA repair [GO:0006281] mitochondrion [GO:0005739]; nucleus [GO:0005634] DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; exonuclease activity [GO:0004527]; metal ion binding [GO:0046872] KGLDWVK 14.06000042 0.040216824 846.3313428 0 15.56982 0 19.10804 17.75351 A0A8C0N9W5 A0A8C0N9W5_CANLF DNA-directed RNA polymerase III subunit RPC3 (RNA polymerase III subunit C3) POLR3C Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728] nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666] single-stranded DNA binding [GO:0003697] MTMSAVVK 5.599999905 0.279408065 883.2488574 16.89893 14.75699 14.30815 15.63532 15.56226 A0A8C0PIG4 A0A8C0PIG4_CANLF DNA-directed RNA polymerase subunit POLR3H Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription initiation [GO:0006352] DNA-directed RNA polymerase complex [GO:0000428]; nucleus [GO:0005634] FVLVEMVDTVR 3.670000076 0.652730208 1308.84387 15.5814 17.84719 17.00869 0 0 A0A8C0M5D9 A0A8C0M5D9_CANLF DNA-directed RNA polymerase subunit beta (EC 2.7.7.6) POLR3B Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; snRNA transcription by RNA polymerase III [GO:0042796] cytoplasm [GO:0005737]; RNA polymerase III complex [GO:0005666] DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; DNA/RNA hybrid binding [GO:0071667]; ribonucleoside binding [GO:0032549]; zinc ion binding [GO:0008270] SRTNMAVK 5.789999962 2.43E-13 921.5051413 15.63749 14.66674 14.83341 15.45082 13.45368 A0A8C0TBE3 A0A8C0TBE3_CANLF DNA/RNA-binding protein Alba-like domain-containing protein RPP25 Canis lupus familiaris (Dog) (Canis familiaris) tRNA 5'-leader removal [GO:0001682] centriolar satellite [GO:0034451]; multimeric ribonuclease P complex [GO:0030681]; nucleoplasm [GO:0005654]; ribonuclease MRP complex [GO:0000172] ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204] DALDPR 7.489999771 0.367121857 684.7567062 15.32893 16.22168 16.52383 17.51959 16.60636 A0A8P0SV12 A0A8P0SV12_CANLF DOMON domain-containing protein MOXD2 Canis lupus familiaris (Dog) (Canis familiaris) copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500] SSRSQMPGI 9.199999809 0.228559792 961.6805211 10.82749 13.99589 14.66912 16.61484 15.27388 A0A8C0N2P5 A0A8C0N2P5_CANLF DUF155 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] KSFGTHR 8.329999924 0.311485741 831.2739222 16.60229 0 16.62625 14.8237 16.23826 A0A8C0PZ78 A0A8C0PZ78_CANLF DUF4203 domain-containing protein TM7SF3 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to unfolded protein [GO:0034620]; negative regulation of programmed cell death [GO:0043069]; positive regulation of insulin secretion [GO:0032024] plasma membrane [GO:0005886] VVTLTANDK 8.880000114 0.287934616 959.6425466 16.46407 15.50004 15.72434 19.28799 15.78961 A0A8C0NG60 A0A8C0NG60_CANLF DUF4550 domain-containing protein CFAP92 Canis lupus familiaris (Dog) (Canis familiaris) NTMVLKNK 7.170000076 0.311522522 963.3935752 15.70651 15.2325 19.2181 16.80986 15.87254 A0A8C0MRY8 A0A8C0MRY8_CANLF DUF4757 domain-containing protein LIMCH1 Canis lupus familiaris (Dog) (Canis familiaris) FARSSSLLDMR 4.409999847 0.532521205 1297.303541 0 17.57156 14.90818 16.06534 14.80225 A0A8C0ME12 A0A8C0ME12_CANLF DUF4795 domain-containing protein C6H16orf96 Canis lupus familiaris (Dog) (Canis familiaris) ITAETLRK 13.64999962 0.307892632 932.6814464 13.42591 16.28848 16.37545 16.26333 15.35679 A0A8C0SN20 A0A8C0SN20_CANLF Decapping nuclease (EC 3.6.1.-) DXO Canis lupus familiaris (Dog) (Canis familiaris) mRNA catabolic process [GO:0006402]; NAD-cap decapping [GO:0110155] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; nuclease activity [GO:0004518]; nucleotide binding [GO:0000166]; RNA binding [GO:0003723] EGLDHLLR 2.140000105 0.250030488 952.5779551 15.63589 11.54887 14.78788 15.69401 12.96231 A0A8C0Q4A7 A0A8C0Q4A7_CANLF Decaprenyl diphosphate synthase subunit 1 PDSS1 Canis lupus familiaris (Dog) (Canis familiaris) isoprenoid biosynthetic process [GO:0008299]; ubiquinone biosynthetic process [GO:0006744] transferase complex [GO:1990234] all-trans-decaprenyl-diphosphate synthase activity [GO:0097269]; all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity [GO:0052923]; protein heterodimerization activity [GO:0046982]; trans-hexaprenyltranstransferase activity [GO:0000010] AVLAGDLILSAASMALAR 7.690000057 0.39781033 1744.161614 0 0 17.92334 0 15.08422 A0A8I3MID0 A0A8I3MID0_CANLF Dedicator of cytokinesis 8 DOCK8 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to chemokine [GO:1990869]; dendritic cell migration [GO:0036336]; immunological synapse formation [GO:0001771]; memory T cell proliferation [GO:0061485]; negative regulation of T cell apoptotic process [GO:0070233]; positive regulation of establishment of T cell polarity [GO:1903905]; positive regulation of T cell migration [GO:2000406]; small GTPase mediated signal transduction [GO:0007264] cytosol [GO:0005829]; leading edge membrane [GO:0031256] guanyl-nucleotide exchange factor activity [GO:0005085] LNFTNK 5.420000076 0.400085145 736.0412755 14.83913 16.63801 0 15.93745 16.54148 A0A8C0TNG0 A0A8C0TNG0_CANLF Deleted in azoospermia like Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; protein-containing complex [GO:0032991] mRNA 3'-UTR binding [GO:0003730] SPAGHASVR 2.950000048 0.274756544 880.8728426 18.28637 18.08769 18.48685 20.66619 17.0959 A0A8C0PYL2 A0A8C0PYL2_CANLF Dentin matrix acidic phosphoprotein 1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; ossification [GO:0001503] GNSRMNSASVK 2.549999952 0.288855875 1167.182303 16.43547 15.42687 15.3332 15.371 15.2587 Q7YRU7 DSG3_CANLF Desmoglein-3 DSG3 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] desmosome [GO:0030057]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] AICSSLRSVVVSAR 7.039999962 0.919744108 1503.497428 17.33096 0 16.15196 0 0 A0A8C0MAS3 A0A8C0MAS3_CANLF Desmoplakin SH3 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament cytoskeleton organization [GO:0045104] cytoskeleton [GO:0005856] RELDAEVSR 25.03000069 0 1075.217192 0 14.31015 0 17.75272 15.48569 A0A8C0NBF3 A0A8C0NBF3_CANLF Deuterosome assembly protein 1 (Coiled-coil domain-containing protein 67) DEUP1 Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030] cytoplasm [GO:0005737] QQVSDMR 4.920000076 0.328784871 879.6612077 14.7581 15.91721 0 14.93657 15.54456 A0A8C0NJ31 A0A8C0NJ31_CANLF Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl peptidase III) DPP3 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cytoplasm [GO:0005737] aminopeptidase activity [GO:0004177]; dipeptidyl-peptidase activity [GO:0008239]; metal ion binding [GO:0046872]; metalloexopeptidase activity [GO:0008235] FVPNLPK 10.39000034 0.03544262 814.5982442 13.00381 13.91139 17.31782 13.06448 12.63604 A0A8C0NCU9 A0A8C0NCU9_CANLF Dipeptidyl peptidase 4 (EC 3.4.14.5) (Dipeptidyl peptidase IV) (T-cell activation antigen CD26) DPP4 Canis lupus familiaris (Dog) (Canis familiaris) behavioral fear response [GO:0001662]; endothelial cell migration [GO:0043542]; locomotory exploration behavior [GO:0035641]; negative regulation of extracellular matrix disassembly [GO:0010716]; negative regulation of neutrophil chemotaxis [GO:0090024]; positive regulation of cell population proliferation [GO:0008284]; proteolysis [GO:0006508]; psychomotor behavior [GO:0036343]; regulation of cell-cell adhesion mediated by integrin [GO:0033632]; response to hypoxia [GO:0001666]; T cell activation [GO:0042110]; T cell costimulation [GO:0031295] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; endocytic vesicle [GO:0030139]; intercellular canaliculus [GO:0046581]; lamellipodium membrane [GO:0031258]; membrane raft [GO:0045121] chemorepellent activity [GO:0045499]; dipeptidyl-peptidase activity [GO:0008239]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; serine-type endopeptidase activity [GO:0004252]; virus receptor activity [GO:0001618] IMHAVNR 5.559999943 0.310402943 840.8187595 13.63891 16.00353 15.83294 15.73708 18.00145 A0A8C0PD19 A0A8C0PD19_CANLF Disco interacting B DIP2B Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of axon extension [GO:0030517]; positive regulation of peptidyl-lysine acetylation [GO:2000758] axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; nucleus [GO:0005634]; perikaryon [GO:0043204] alpha-tubulin binding [GO:0043014] ILPGVK 3.319999933 0.293465823 626.9461166 13.88765 15.4318 14.82209 14.81549 14.6623 A0A8C0NEA1 A0A8C0NEA1_CANLF DnaJ heat shock protein family (Hsp40) member C14 DNAJC14 LOC102156933 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] KEYEMK 4.690000057 0.303892538 842.6126703 15.18627 17.21545 0 14.40557 16.18987 A0A8C0QL37 A0A8C0QL37_CANLF DnaJ homolog subfamily A member 1 Canis lupus familiaris (Dog) (Canis familiaris) protein folding [GO:0006457] membrane [GO:0016020]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471] Hsp70 protein binding [GO:0030544]; metal ion binding [GO:0046872]; unfolded protein binding [GO:0051082] GGTGMQIR 6.840000153 0.270248257 818.3542747 16.0107 14.6372 15.42306 14.29212 15.72163 A0A8C0NXS9 A0A8C0NXS9_CANLF Dynamin-type G domain-containing protein MFN1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial fusion [GO:0008053] mitochondrial outer membrane [GO:0005741] GTP binding [GO:0005525]; GTPase activity [GO:0003924] LHTYVS 9.020000458 0.185505492 718.5732991 17.95997 16.68356 17.30718 20.21095 17.85828 A0A8C0PFU5 A0A8C0PFU5_CANLF Dynein axonemal light chain 1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] EAVGDTLEELWISYNFIEK 5.25 0.36208566 2255.596735 15.84179 13.20472 12.62714 14.33128 12.11253 A0A8C0S0J3 A0A8C0S0J3_CANLF Dynein cytoplasmic 1 heavy chain 1 DYNC1H1 Canis lupus familiaris (Dog) (Canis familiaris) establishment of spindle localization [GO:0051293]; microtubule-based movement [GO:0007018]; P-body assembly [GO:0033962]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of intracellular transport [GO:0032388]; positive regulation of spindle assembly [GO:1905832]; regulation of metaphase plate congression [GO:0090235]; regulation of mitotic spindle organization [GO:0060236]; stress granule assembly [GO:0034063] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; filopodium [GO:0030175]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] DLEASIARYK 3.480000019 0.089550421 1164.809569 14.6458 16.65477 14.30668 15.26039 13.90277 A0A8C0PPT1 A0A8C0PPT1_CANLF Dynein heavy chain tail domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] dynein complex [GO:0030286] dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] DVDHMVR 4.389999866 0.380936959 886.9253677 15.12283 13.95024 16.22835 14.47222 15.8174 A0A8C0M296 A0A8C0M296_CANLF Dynein light chain Tctex-type family member 5 DYNLT5 Canis lupus familiaris (Dog) (Canis familiaris) ELHGYTK 5.079999924 0.344702878 847.9031823 18.03716 16.37276 18.30615 18.48132 18.4371 A0A8I3PX56 A0A8I3PX56_CANLF E1A binding protein p400 EP400 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of cell cycle [GO:0051726] NuA4 histone acetyltransferase complex [GO:0035267]; nuclear speck [GO:0016607]; nucleosome [GO:0000786]; Swr1 complex [GO:0000812] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658] GRLLVCVAR 3.660000086 0.049374767 1044.444272 16.69245 16.042 15.77881 15.28697 15.54153 A0A8C0QN41 A0A8C0QN41_CANLF E3 ubiquitin protein ligase (EC 2.3.2.27) RNF20 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cell migration [GO:0030336]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] HULC complex [GO:0033503]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone H2B C-terminal K residue ubiquitin ligase activity [GO:0140850]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; p53 binding [GO:0002039]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase binding [GO:0031625] LLLDMYR 19.53000069 0.054934983 923.6595675 19.06994 19.96204 20.4041 19.43303 20.81871 A0A8C0TAY8 A0A8C0TAY8_CANLF E3 ubiquitin-protein ligase RNF10 (RING finger protein 10) RNF10 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116] cytosolic ribosome [GO:0022626] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] IEMEENKK 5.590000153 0.031823338 1036.359812 9.299374 12.65388 13.67705 11.7072 13.78249 A0A8C0NSU1 A0A8C0NSU1_CANLF EF-hand domain containing 1 EFHC1 Canis lupus familiaris (Dog) (Canis familiaris) ESGPEKR 7 0.281792876 802.6772094 15.87132 15.21224 14.21773 15.50858 15.90552 A0A8P0P4D8 A0A8P0P4D8_CANLF EF-hand domain-containing protein KCNIP3 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] VVAAPRPMSAR 4.75 2.49E-13 1169.813389 0 13.00145 15.78338 11.94065 12.59335 A0A8C0PA60 A0A8C0PA60_CANLF EF-hand domain-containing protein RCN1 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] DYDRDK 5.860000134 0.432884578 810.8329421 14.86725 14.09409 16.28017 14.82344 14.63995 A0A8C0RKT3 A0A8C0RKT3_CANLF EF-hand domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule organizing center [GO:0005815] calcium ion binding [GO:0005509] MCKGTR 2.359999895 0.328043113 768.6760144 17.20809 0 20.14338 16.64116 0 A0A8C0M025 A0A8C0M025_CANLF "EGF like, fibronectin type III and laminin G domains" EGFLAM Canis lupus familiaris (Dog) (Canis familiaris) basement membrane [GO:0005604]; cell projection [GO:0042995] calcium ion binding [GO:0005509] STGTNR 4.75 0.266149993 635.1398013 16.16546 18.54114 17.99571 17.21423 16.92514 A0A8C0QCZ8 A0A8C0QCZ8_CANLF ENTH domain-containing protein EPN1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] lipid binding [GO:0008289] AHALKTK 1.299999952 0.33809047 768.9123322 15.53465 15.83323 17.40047 15.69372 16.54575 A0A8C0TAT6 A0A8C0TAT6_CANLF EWS RNA binding protein 1 EWSR1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723] GGMGAGER 5.96999979 0.323855203 752.1220718 17.02631 15.15007 15.45343 15.77144 15.28524 A0A8C0P1S7 A0A8C0P1S7_CANLF EWS RNA binding protein 1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723] GGRGMDR 4.440000057 0.38581982 763.2153152 15.07911 15.46935 16.79513 15.07151 14.81096 A0A8C0MEM1 A0A8C0MEM1_CANLF EamA domain-containing protein SLC35F3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LLLGSAK 22.97999954 0 702.6086844 0 16.15011 0 17.36128 15.62898 A0A8I3PJ50 A0A8I3PJ50_CANLF Early endosome antigen 1 EEA1 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897]; modulation by host of viral process [GO:0044788]; vesicle fusion [GO:0006906] cytosol [GO:0005829]; early endosome membrane [GO:0031901] 1-phosphatidylinositol binding [GO:0005545]; GTP-dependent protein binding [GO:0030742]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803] RDDITLLR 5.71999979 1.23E-13 1001.523907 14.34219 14.60495 0 13.61952 10.81383 A0A8I3RRD0 A0A8I3RRD0_CANLF Ectopic P-granules 5 autophagy tethering factor EPG5 Canis lupus familiaris (Dog) (Canis familiaris) autophagosome maturation [GO:0097352]; cellular response to dsDNA [GO:1990786]; endocytic recycling [GO:0032456]; endosome to lysosome transport [GO:0008333]; nucleotide transport [GO:0006862]; toll-like receptor 9 signaling pathway [GO:0034162] lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471] TNVDEDFIK 6.880000114 0 1080.691975 11.02792 11.66241 11.0392 14.65222 13.97898 A0A8C0NPH6 A0A8C0NPH6_CANLF Elongation of very long chain fatty acids protein 5 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL5) (ELOVL fatty acid elongase 5) (ELOVL FA elongase 5) (Very long chain 3-ketoacyl-CoA synthase 5) (Very long chain 3-oxoacyl-CoA synthase 5) ELOVL5 Canis lupus familiaris (Dog) (Canis familiaris) "fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]" dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789] fatty acid elongase activity [GO:0009922] SAGEADMK 10.03999996 0.295461817 807.2342897 16.13393 12.42873 15.91507 16.65037 16.26378 A0A8C0Q163 A0A8C0Q163_CANLF Elongation of very long chain fatty acids protein (EC 2.3.1.199) (Very-long-chain 3-oxoacyl-CoA synthase) Canis lupus familiaris (Dog) (Canis familiaris) fatty acid biosynthetic process [GO:0006633] membrane [GO:0016020] fatty acid elongase activity [GO:0009922] LIKILYPR 5.5 0.26965005 1016.421653 16.01757 18.20504 0 13.10201 17.28031 A0A8C0M0U1 A0A8C0M0U1_CANLF Elongator complex protein 2 ELP2 Canis lupus familiaris (Dog) (Canis familiaris) tRNA wobble uridine modification [GO:0002098] cytoplasm [GO:0005737]; elongator holoenzyme complex [GO:0033588]; nucleus [GO:0005634] VLRVFSAPR 5.800000191 0.308477803 1045.615766 15.61774 17.94342 16.16781 15.16367 16.0438 A0A8C0P5C0 A0A8C0P5C0_CANLF Endoplasmic reticulum-Golgi intermediate compartment protein ERGIC3 Canis lupus familiaris (Dog) (Canis familiaris) "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139] TLEDFR 7.289999962 0.265658925 780.4126423 17.37971 14.76454 14.15248 12.35573 14.20195 A0A8C0MWV1 A0A8C0MWV1_CANLF Enhancer of mRNA-decapping protein 3 (YjeF domain-containing protein 1) EDC3 Canis lupus familiaris (Dog) (Canis familiaris) P-body [GO:0000932] ITVPHNVSK 11.22999954 0.311856055 994.0001732 15.74115 14.88712 14.36396 15.13431 14.09069 A0A8C0PB38 A0A8C0PB38_CANLF Estrogen related receptor gamma ESRRG Canis lupus familiaris (Dog) (Canis familiaris) retinoic acid receptor signaling pathway [GO:0048384] nucleus [GO:0005634] nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; sequence-specific DNA binding [GO:0043565]; steroid binding [GO:0005496]; zinc ion binding [GO:0008270] SMKLEK 3.410000086 0 751.7387471 13.93899 9.504248 12.90257 10.85904 11.46791 A0A8C0MUC2 A0A8C0MUC2_CANLF Eukaryotic translation initiation factor 2A (eIF-2A) EIF2A Canis lupus familiaris (Dog) (Canis familiaris) translation initiation factor activity [GO:0003743] INVINVTNK 12.06000042 0.125861924 1014.815172 13.15552 18.9099 0 16.54381 0 A0A8C0NGL3 A0A8C0NGL3_CANLF Eukaryotic translation initiation factor 3 subunit J (eIF3j) (Eukaryotic translation initiation factor 3 subunit 1) (eIF-3-alpha) (eIF3 p35) EIF3J EIF3S1 Canis lupus familiaris (Dog) (Canis familiaris) formation of cytoplasmic translation initiation complex [GO:0001732] cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852] identical protein binding [GO:0042802]; translation initiation factor activity [GO:0003743] DKITQYEK 2.809999943 0.348577765 1025.168682 17.41474 16.92343 15.87154 15.92774 16.31929 A0A8C0M8S2 A0A8C0M8S2_CANLF Eukaryotic translation initiation factor 4 gamma 3 EIF4G3 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] RADQGPK 3.160000086 0.097606647 772.2253011 15.45576 16.45984 14.32117 14.17048 13.39216 A0A8C0QL75 A0A8C0QL75_CANLF Eukaryotic translation initiation factor 6 (eIF-6) EIF6 ITGB4BP Canis lupus familiaris (Dog) (Canis familiaris) cytosolic ribosome assembly [GO:0042256]; ribosomal large subunit biogenesis [GO:0042273]; ribosomal subunit export from nucleus [GO:0000054] cytoplasm [GO:0005737]; nucleolus [GO:0005730] ribosomal large subunit binding [GO:0043023]; translation initiation factor activity [GO:0003743] VHVPTVCSR 10.35000038 0.238226959 1054.169589 15.7339 16.18811 13.91649 11.7928 15.12149 A0A8C0NXT9 A0A8C0NXT9_CANLF Exportin 1 XPO1 Canis lupus familiaris (Dog) (Canis familiaris) mRNA export from nucleus [GO:0006406]; protein export from nucleus [GO:0006611]; protein localization to nucleus [GO:0034504]; regulation of centrosome duplication [GO:0010824]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of protein export from nucleus [GO:0046825]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit export from nucleus [GO:0000056] annulate lamellae [GO:0005642]; cytosol [GO:0005829]; kinetochore [GO:0000776]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904] nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267] QPLIRSMR 35.08000183 0.531678291 1018.578696 16.6656 17.00433 15.10028 16.37174 16.39857 A0A8I3PGU4 A0A8I3PGU4_CANLF Exportin-4 XPO4 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] nucleus [GO:0005634] nuclear export signal receptor activity [GO:0005049] MEAVVR 4.900000095 0.106381069 704.9141537 17.74152 15.53993 17.69981 19.83171 15.94467 A0A8C0N5R6 A0A8C0N5R6_CANLF Exportin-T (Exportin(tRNA)) (tRNA exportin) XPOT Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; tRNA re-export from nucleus [GO:0071528] cytoplasm [GO:0005737]; nucleus [GO:0005634] small GTPase binding [GO:0031267]; tRNA binding [GO:0000049] ASALQDMMR 2.089999914 0.116618364 1022.418839 17.37936 12.52544 12.18075 13.67722 13.7933 A0A8C0NRB9 A0A8C0NRB9_CANLF Extended synaptotagmin 1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum-plasma membrane tethering [GO:0061817]; lipid transport [GO:0006869] endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] lipid binding [GO:0008289] AQDLPLK 11.96000004 0.161128421 783.289177 23.39029 22.50583 17.30717 17.82416 16.42329 A0A8C0N4H3 A0A8C0N4H3_CANLF Extracellular leucine rich repeat and fibronectin type III domain containing 2 ELFN2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] MQEEKQK 2 0.413249687 918.9783076 16.39587 15.19629 13.67386 14.95748 15.14733 A0A8C0PV53 A0A8C0PV53_CANLF Extracellular matrix protein 2 ECM2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811] interstitial matrix [GO:0005614] collagen V binding [GO:0070052]; heparin binding [GO:0008201] SLSYLR 2.99000001 0.370228356 739.0122936 16.38666 0 0 14.89381 15.01639 A0A8C0M9V2 A0A8C0M9V2_CANLF Eyes absent homolog (EC 3.1.3.48) EYA4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872]; protein tyrosine phosphatase activity [GO:0004725] AEIEGLTDSWLTNALK 4.389999866 0.668327652 1761.212183 18.28637 0 0 20.66619 18.27886 A0A8C0T185 A0A8C0T185_CANLF F-actin monooxygenase (EC 1.14.13.225) MICAL2 Canis lupus familiaris (Dog) (Canis familiaris) actin filament depolymerization [GO:0030042] cytoplasm [GO:0005737]; nucleus [GO:0005634] actin binding [GO:0003779]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; monooxygenase activity [GO:0004497] NPSLLKQAK 6.739999771 0.237692854 998.9854136 14.668 12.83493 15.28801 16.924 12.36159 A0A8C0M8A6 A0A8C0M8A6_CANLF F-box and leucine rich repeat protein 19 FBXL19 Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677]; zinc ion binding [GO:0008270] MSSSSR 3.00999999 0.29437357 655.554389 16.3333 15.10063 17.09322 16.94606 17.79665 A0A8C0NPQ4 A0A8C0NPQ4_CANLF F-box protein 30 FBXO30 Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] SYENLSR 1.50999999 0.187889508 868.6860914 16.69934 14.84002 15.38714 0 17.60136 A0A8I3N884 A0A8I3N884_CANLF FA complementation group D2 FANCD2 Canis lupus familiaris (Dog) (Canis familiaris) brain morphogenesis [GO:0048854]; cellular response to oxidative stress [GO:0034599]; DNA repair [GO:0006281]; gamete generation [GO:0007276]; homologous chromosome pairing at meiosis [GO:0007129]; neuronal stem cell population maintenance [GO:0097150]; regulation of CD40 signaling pathway [GO:2000348]; regulation of inflammatory response [GO:0050727]; regulation of regulatory T cell differentiation [GO:0045589]; response to gamma radiation [GO:0010332] condensed chromosome [GO:0000793]; cytosol [GO:0005829]; DNA repair complex [GO:1990391]; nuclear body [GO:0016604]; nucleolus [GO:0005730] DNA polymerase binding [GO:0070182] LIISQLK 18.42000008 0.078815324 814.6075832 0 19.6849 17.76392 19.27681 18.87456 A0A0K1MBN7 A0A0K1MBN7_CANLF FAM134B FAM134B Canis lupus familiaris (Dog) (Canis familiaris) reticulophagy [GO:0061709] endoplasmic reticulum membrane [GO:0005789] ISLTVAAK 4.940000057 0.235842688 801.172407 12.5967 16.41118 14.70479 0 15.1175 A0A8C0LU91 A0A8C0LU91_CANLF FAM69 N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] AHPGVR 6.769999981 0.436153656 634.8416271 15.13468 16.23242 16.54601 16.27735 16.09872 A0A8C0S165 A0A8C0S165_CANLF FAT atypical cadherin 1 Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015]; epithelial cell morphogenesis [GO:0003382]; establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis [GO:0003412]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; lens development in camera-type eye [GO:0002088] apical plasma membrane [GO:0016324]; cell-cell junction [GO:0005911]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] calcium ion binding [GO:0005509] TYSAHAVVMYAR 2.190000057 0 1369.469078 15.28814 15.20275 13.06224 0 0 A0A8P0PGP5 A0A8P0PGP5_CANLF FERM domain containing kindlin 2 FERMT2 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] MMLGQRK 5.329999924 0.031130118 879.3615257 11.54179 14.44278 13.83181 16.73797 13.31068 A0A8C0S1R4 A0A8C0S1R4_CANLF FERM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] cytoskeletal protein binding [GO:0008092] EPQPEPPPK 28.54999924 0.561484085 1018.628251 21.21026 18.79177 17.92404 18.43236 18.39597 A0A8C0NV71 A0A8C0NV71_CANLF FHA domain-containing protein CEP170 Canis lupus familiaris (Dog) (Canis familiaris) AMDISAMPR 7.989999771 1.22E-13 1007.214272 0 9.529365 11.82312 15.41033 13.24757 Q7YRI1 Q7YRI1_CANLF FUN14 domain-containing protein 2 (Hepatitis C virus core-binding protein 6) Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634] MGGVTGWR 2.970000029 0.340253319 863.8190952 16.90423 14.45849 17.09293 18.00382 14.32387 A0A8C0NA58 A0A8C0NA58_CANLF "FYVE, RhoGEF and PH domain containing 6" NR2C1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872] QLILEPLEMR 16.59000015 0.313986296 1241.713907 15.15696 0 16.2166 0 17.11383 A0A8C0M962 A0A8C0M962_CANLF Family with sequence similarity 114 member A1 Canis lupus familiaris (Dog) (Canis familiaris) ENSCSSR 2.569999933 0.298386652 838.6106137 14.58331 15.27917 14.38635 16.11551 16.38662 A0A8C0NYD2 A0A8C0NYD2_CANLF Family with sequence similarity 117 member B Canis lupus familiaris (Dog) (Canis familiaris) DSHGQAAPCMRDK 4.829999924 0 1488.409711 14.82709 15.21464 13.20372 16.41465 14.69136 A0A8C0PN35 A0A8C0PN35_CANLF Family with sequence similarity 120A Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] LSRNGK 8.880000114 0.080340573 675.5454682 15.50728 13.24168 15.07228 15.23564 14.90196 A0A8C0PL64 A0A8C0PL64_CANLF Family with sequence similarity 13 member C FAM13C Canis lupus familiaris (Dog) (Canis familiaris) VLLPDEK 5.079999924 0.266668397 811.8014011 9.718749 15.88158 13.88035 14.45436 13.50347 A0A8C0P2U4 A0A8C0P2U4_CANLF Family with sequence similarity 135 member B FAM135B Canis lupus familiaris (Dog) (Canis familiaris) DNADLRK 3.559999943 1.23E-13 832.5160803 15.20518 13.87918 17.24887 14.10648 13.21126 A0A8C0YSI4 A0A8C0YSI4_CANLF Family with sequence similarity 171 member B FAM171B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SATLPR 5.079999924 0.314080006 643.3639678 16.47785 15.99127 15.00246 16.91605 16.02041 A0A8C0M307 A0A8C0M307_CANLF Family with sequence similarity 189 member A1 ENTREP2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] RARPAGAGGVR 2.519999981 0.183743877 1068.203832 13.48976 15.34325 15.00624 12.33458 13.419 A0A8C0RBV9 A0A8C0RBV9_CANLF Family with sequence similarity 193 member B FAM193B Canis lupus familiaris (Dog) (Canis familiaris) KEEPPMK 4.369999886 0.315615428 872.9844889 17.34626 13.57451 13.78284 14.88654 17.37804 A0A8C0MLR2 A0A8C0MLR2_CANLF Family with sequence similarity 227 member B Canis lupus familiaris (Dog) (Canis familiaris) SIIFDTR 8.680000305 0 852.5056522 11.30683 13.0842 11.70843 14.25685 11.188 A0A8C0N5W1 A0A8C0N5W1_CANLF Far upstream element binding protein 3 FUBP3 Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytoplasm [GO:0005737]; nucleus [GO:0005634] RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697] AAQVMGPPDR 7.090000153 0.266292374 1057.874748 15.4623 16.8919 12.95841 14.36552 14.99729 A0A8P0NHE2 A0A8P0NHE2_CANLF Ferritin FTH1 LOC403631 Canis lupus familiaris (Dog) (Canis familiaris) intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] ferric iron binding [GO:0008199] RGHPPRPAR 3.730000019 0.278830942 1042.82013 15.1396 13.54504 16.04869 16.80109 15.92061 A0A8C0MK61 A0A8C0MK61_CANLF Ferrochelatase (EC 4.98.1.1) Canis lupus familiaris (Dog) (Canis familiaris) heme biosynthetic process [GO:0006783] mitochondrial inner membrane [GO:0005743] "2 iron, 2 sulfur cluster binding [GO:0051537]; ferrochelatase activity [GO:0004325]" GRPGSAVR 4.110000134 0.399399383 799.8111745 15.53476 16.12831 17.00383 15.39024 16.56299 E2RK30 PKHD1_CANLF Fibrocystin (Polycystic kidney and hepatic disease 1 protein) (Polyductin) PKHD1 Canis lupus familiaris (Dog) (Canis familiaris) branching morphogenesis of an epithelial tube [GO:0048754]; cell-cell junction organization [GO:0045216]; epithelial cell morphogenesis [GO:0003382]; establishment of centrosome localization [GO:0051660]; establishment of mitotic spindle orientation [GO:0000132]; negative regulation of epithelial cell apoptotic process [GO:1904036]; positive regulation of epithelial cell proliferation [GO:0050679]; regulation of cell adhesion [GO:0030155]; regulation of cell-cell adhesion [GO:0022407]; regulation of cell-matrix adhesion [GO:0001952]; regulation of cholangiocyte proliferation [GO:1904054]; regulation of establishment of planar polarity [GO:0090175] "apical plasma membrane [GO:0016324]; chromosome, centromeric region [GO:0000775]; cilium [GO:0005929]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; spindle [GO:0005819]" ARLLVGSFR 25.27000046 0.081577246 1018.94463 17.96181 23.2327 19.88671 22.33038 18.36972 A0A8C0T783 A0A8C0T783_CANLF Fibronectin FN1 Canis lupus familiaris (Dog) (Canis familiaris) "acute-phase response [GO:0006953]; biological process involved in interaction with symbiont [GO:0051702]; calcium-independent cell-matrix adhesion [GO:0007161]; cell-substrate junction assembly [GO:0007044]; endodermal cell differentiation [GO:0035987]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of monocyte activation [GO:0150102]; negative regulation of transforming growth factor beta production [GO:0071635]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; positive regulation of axon extension [GO:0045773]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of substrate-dependent cell migration, cell attachment to substrate [GO:1904237]; regulation of cell shape [GO:0008360]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of protein phosphorylation [GO:0001932]; substrate adhesion-dependent cell spreading [GO:0034446]; wound healing [GO:0042060]" apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; fibrinogen complex [GO:0005577] heparin binding [GO:0008201]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; peptidase activator activity [GO:0016504]; protease binding [GO:0002020]; proteoglycan binding [GO:0043394] NGPGPSK 10.47999954 0.271999252 655.3344969 18.10878 15.96204 16.21584 15.23117 15.65427 A0A8C0LQV1 A0A8C0LQV1_CANLF Fibronectin type III and SPRY domain containing 2 FSD2 Canis lupus familiaris (Dog) (Canis familiaris) FASSRHK 3.430000067 0.222358758 832.480643 0 15.36026 16.65462 17.63152 17.12708 A0A8C0RMM7 A0A8C0RMM7_CANLF Fibronectin type-III domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) SVIVSSLDPNHK 8.159999847 0.532431388 1296.130556 16.72746 15.15731 16.95225 15.55775 14.90526 Q95LA1 FMO3_CANLF Flavin-containing monooxygenase 3 (EC 1.14.13.148) (EC 1.14.13.32) (EC 1.14.13.8) (Dimethylaniline monooxygenase [N-oxide-forming] 3) (Dimethylaniline oxidase 3) (Hepatic flavin-containing monooxygenase 3) (FMO 3) (Trimethylamine monooxygenase) FMO3 Canis lupus familiaris (Dog) (Canis familiaris) taurine biosynthetic process [GO:0042412] endoplasmic reticulum membrane [GO:0005789] "albendazole monooxygenase activity [GO:0047638]; flavin adenine dinucleotide binding [GO:0050660]; hypotaurine dehydrogenase activity [GO:0047822]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]; trimethylamine monooxygenase activity [GO:0034899]" GIFPPK 8.18999958 0.327928242 658.5983163 15.47604 16.25878 0 14.90972 14.6701 A0A8C0REX0 A0A8C0REX0_CANLF Fork-head domain-containing protein FOXF2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] DDLPVGLPR 2.619999886 0.004651749 982.3113448 17.67761 12.73761 12.87519 16.46704 14.86662 A0A8C0MIJ8 A0A8C0MIJ8_CANLF Fork-head domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GGEPAGGGGR 4.070000172 0 813.6267033 12.2064 5.993768 13.53108 0 14.43857 A0A8C0Q7M4 A0A8C0Q7M4_CANLF Forkhead box K2 FOXK2 Canis lupus familiaris (Dog) (Canis familiaris) canonical glycolysis [GO:0061621]; intracellular glucose homeostasis [GO:0001678]; negative regulation of autophagy [GO:0010507]; regulation of glucose metabolic process [GO:0010906]; response to starvation [GO:0042594] mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; magnesium ion binding [GO:0000287]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IDPASESK 3.650000095 0.365090799 848.039829 15.4173 0 16.21329 14.92334 15.82934 A0A8C0MGQ1 A0A8C0MGQ1_CANLF Fucose kinase FCSK Canis lupus familiaris (Dog) (Canis familiaris) organic substance metabolic process [GO:0071704]; primary metabolic process [GO:0044238] "ATP binding [GO:0005524]; kinase activity [GO:0016301]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]" REQIPAR 4.190000057 0.088531533 869.2906618 19.92032 17.52168 18.18784 17.37509 18.59299 A0A8C0NZZ1 A0A8C0NZZ1_CANLF "Fumarate hydratase, mitochondrial (EC 4.2.1.2)" FH Canis lupus familiaris (Dog) (Canis familiaris) fumarate metabolic process [GO:0006106]; homeostasis of number of cells within a tissue [GO:0048873]; malate metabolic process [GO:0006108]; positive regulation of cold-induced thermogenesis [GO:0120162]; tricarboxylic acid cycle [GO:0006099] mitochondrial matrix [GO:0005759]; tricarboxylic acid cycle enzyme complex [GO:0045239] fumarate hydratase activity [GO:0004333] AFGILKR 3 0.047986845 805.248948 15.86496 16.27285 16.40707 15.81358 16.99501 A0A8C0N478 A0A8C0N478_CANLF Fumarylacetoacetase-like C-terminal domain-containing protein KCNIP3 Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] QTTSKPAVVR 2.319999933 0.26926119 1086.357463 17.48096 15.30283 17.56845 15.3283 14.96054 A0A8C0SF56 A0A8C0SF56_CANLF "G protein-activated inward rectifier potassium channel 1 (Inward rectifier K(+) channel Kir3.1) (Potassium channel, inwardly rectifying subfamily J member 3)" KCNJ3 Canis lupus familiaris (Dog) (Canis familiaris) potassium ion import across plasma membrane [GO:1990573] parallel fiber to Purkinje cell synapse [GO:0098688]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076] G-protein activated inward rectifier potassium channel activity [GO:0015467] DGKLTLMFR 13.18999958 0.267491345 1081.37612 15.75753 15.40964 17.14734 16.00849 15.99312 A0A8C0NZ81 A0A8C0NZ81_CANLF G protein-coupled receptor 12 GPR12 Canis lupus familiaris (Dog) (Canis familiaris) intracellular calcium ion homeostasis [GO:0006874] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; phosphatidylcholine binding [GO:0031210] VNLSGLPR 2.230000019 0.191654353 854.5624122 17.49016 14.91527 16.67143 16.03655 15.83204 A0A8C0M6Q4 A0A8C0M6Q4_CANLF G protein-regulated inducer of neurite outgrowth C-terminal domain-containing protein GPRIN1 Canis lupus familiaris (Dog) (Canis familiaris) VDTVSPGK 9.510000229 0.184934739 801.2948498 17.38374 16.39312 15.72902 14.84565 17.11886 A0A8C0LYY6 A0A8C0LYY6_CANLF G-patch domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397] nucleic acid binding [GO:0003676] SKVGPPK 4.909999847 0.352516597 712.1296739 17.53425 16.31632 14.96554 14.93862 16.23984 A0A8C0SY01 A0A8C0SY01_CANLF G-protein coupled receptors family 1 profile domain-containing protein GPR174 Canis lupus familiaris (Dog) (Canis familiaris) T cell homeostasis [GO:0043029] centriolar satellite [GO:0034451]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] bioactive lipid receptor activity [GO:0045125] TSDDTAGNR 12.36999989 0.356614489 934.9651586 15.64896 15.77521 0 14.59059 17.98522 A0A8C0SDF5 A0A8C0SDF5_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] AVRPQRR 7.139999866 0.104026469 881.203046 10.66835 0 13.87059 13.69749 15.60078 A0A8C0RM89 A0A8C0RM89_CANLF G-protein coupled receptors family 3 profile domain-containing protein GRM1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to electrical stimulus [GO:0071257]; L-glutamate import across plasma membrane [GO:0098712]; locomotory behavior [GO:0007626]; phospholipase C-activating G protein-coupled glutamate receptor signaling pathway [GO:0007206]; positive regulation of MAPK cascade [GO:0043410]; regulation of sensory perception of pain [GO:0051930]; sensory perception of pain [GO:0019233] dendrite [GO:0030425]; G protein-coupled receptor homodimeric complex [GO:0038038]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; Schaffer collateral - CA1 synapse [GO:0098685] G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:0098872]; glutamate receptor activity [GO:0008066] ILAGSK 10.82999992 0.413262488 589.0520207 15.216 16.12173 15.03342 15.95374 16.23241 A0A8C0RQI0 A0A8C0RQI0_CANLF GDNF inducible zinc finger protein 1 GZF1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] GLLPPR 7.769999981 0.310175749 651.3201577 19.17516 17.02151 16.34372 15.45256 16.79129 A0A8I3P013 A0A8I3P013_CANLF GLI family zinc finger 3 GLI3 Canis lupus familiaris (Dog) (Canis familiaris) alpha-beta T cell differentiation [GO:0046632]; anterior semicircular canal development [GO:0060873]; anterior/posterior pattern specification [GO:0009952]; artery development [GO:0060840]; axon guidance [GO:0007411]; branching involved in ureteric bud morphogenesis [GO:0001658]; camera-type eye morphogenesis [GO:0048593]; cell differentiation involved in kidney development [GO:0061005]; chondrocyte differentiation [GO:0002062]; developmental growth [GO:0048589]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic digit morphogenesis [GO:0042733]; embryonic neurocranium morphogenesis [GO:0048702]; forebrain dorsal/ventral pattern formation [GO:0021798]; forebrain radial glial cell differentiation [GO:0021861]; frontal suture morphogenesis [GO:0060364]; heart development [GO:0007507]; hindgut morphogenesis [GO:0007442]; hippocampus development [GO:0021766]; in utero embryonic development [GO:0001701]; lambdoid suture morphogenesis [GO:0060366]; larynx morphogenesis [GO:0120223]; lateral ganglionic eminence cell proliferation [GO:0022018]; lateral semicircular canal development [GO:0060875]; layer formation in cerebral cortex [GO:0021819]; lung development [GO:0030324]; mammary gland specification [GO:0060594]; melanocyte differentiation [GO:0030318]; metanephros development [GO:0001656]; negative regulation of alpha-beta T cell differentiation [GO:0046639]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative thymic T cell selection [GO:0045060]; neuroblast proliferation [GO:0007405]; odontogenesis of dentin-containing tooth [GO:0042475]; oligodendrocyte differentiation [GO:0048709]; optic nerve morphogenesis [GO:0021631]; osteoblast differentiation [GO:0001649]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein import into nucleus [GO:0006606]; protein processing [GO:0016485]; proximal/distal pattern formation [GO:0009954]; regulation of bone development [GO:1903010]; roof of mouth development [GO:0060021]; sagittal suture morphogenesis [GO:0060367]; smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:0060831]; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification [GO:0021776]; smoothened signaling pathway involved in ventral spinal cord interneuron specification [GO:0021775]; stem cell proliferation [GO:0072089]; thymocyte apoptotic process [GO:0070242]; tongue development [GO:0043586]; vocalization behavior [GO:0071625] axoneme [GO:0005930]; GLI-SUFU complex [GO:1990788]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; transcription repressor complex [GO:0017053] beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; histone acetyltransferase binding [GO:0035035]; histone deacetylase binding [GO:0042826]; mediator complex binding [GO:0036033]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] ASDPVR 7.380000114 0 644.2190461 13.93798 15.94306 14.51581 15.14847 14.6162 A0A8I3PSR9 A0A8I3PSR9_CANLF GRB10 interacting GYF protein 2 GIGYF2 Canis lupus familiaris (Dog) (Canis familiaris) adult locomotory behavior [GO:0008344]; feeding behavior [GO:0007631]; homeostasis of number of cells within a tissue [GO:0048873]; insulin-like growth factor receptor signaling pathway [GO:0048009]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; mRNA destabilization [GO:0061157]; multicellular organism growth [GO:0035264]; musculoskeletal movement [GO:0050881]; negative regulation of translational initiation [GO:0045947]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; neuromuscular process controlling balance [GO:0050885]; post-embryonic development [GO:0009791]; post-transcriptional gene silencing [GO:0016441]; rescue of stalled ribosome [GO:0072344]; spinal cord motor neuron differentiation [GO:0021522] cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perikaryon [GO:0043204]; protein-containing complex [GO:0032991]; proximal dendrite [GO:1990635] molecular adaptor activity [GO:0060090]; proline-rich region binding [GO:0070064] EEMLALFLK 3.140000105 0.302066127 1110.244241 12.42606 13.6321 16.8274 14.42741 13.80655 A0A8C0PCZ2 A0A8C0PCZ2_CANLF GTP-binding protein GEM Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] RGGGSSVPR 5.670000076 1.23E-13 872.310713 15.26113 15.61515 0 17.51611 16.42612 A0A8I3N5A1 A0A8I3N5A1_CANLF GVQW motif containing 3 GVQW3 Canis lupus familiaris (Dog) (Canis familiaris) ENLNMR 26.73999977 0.086383153 792.5292178 17.7241 15.09487 13.70337 15.02686 14.23574 A0A8P0PP05 A0A8P0PP05_CANLF Gelsolin (ADF) (Actin-depolymerizing factor) GSN Canis lupus familiaris (Dog) (Canis familiaris) actin filament severing [GO:0051014]; barbed-end actin filament capping [GO:0051016]; cilium assembly [GO:0060271] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] actin filament binding [GO:0051015] MELFLFK 1.25999999 0 926.4168787 18.69927 15.72668 17.90381 16.97367 15.44424 A0A8C0RLM4 A0A8C0RLM4_CANLF Gem nuclear organelle associated protein 4 GEMIN4 Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364]; spliceosomal snRNP assembly [GO:0000387] Cajal body [GO:0015030]; cytosol [GO:0005829]; nucleolus [GO:0005730]; SMN complex [GO:0032797] ribonucleoprotein complex binding [GO:0043021] ALTELTK 2.309999943 0.107080145 774.417203 11.35777 12.42777 16.88835 13.56467 14.30958 A0A8C0RED7 A0A8C0RED7_CANLF Gem nuclear organelle associated protein 6 GEMIN6 Canis lupus familiaris (Dog) (Canis familiaris) spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387] cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; SMN complex [GO:0032797] RNA binding [GO:0003723] VTASEK 11.72000027 0.068911094 635.3329688 15.02353 16.04706 16.22736 16.01454 16.06173 A0A8C0NGN6 A0A8C0NGN6_CANLF Germ cell associated 1 GSG1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AIQTSGR 1.669999957 0.302958006 731.6355065 14.94922 14.74162 13.49154 13.3698 14.78942 A0A0S1U0J7 A0A0S1U0J7_CANLF Glial fibrillary acidic protein GFAP Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] EGESHK 7.630000114 1.22E-13 685.209239 0 0 0 13.82908 0 A0A8C0M131 A0A8C0M131_CANLF Globin family profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344] TQPAPAPR 12.17000008 0.035551202 838.2579195 0 14.99051 13.21854 14.63716 14.42234 A0A8P0TUS8 A0A8P0TUS8_CANLF Glutamate decarboxylase 2 (EC 4.1.1.15) (65 kDa glutamic acid decarboxylase) (Glutamate decarboxylase 65 kDa isoform) Canis lupus familiaris (Dog) (Canis familiaris) carboxylic acid metabolic process [GO:0019752] cell projection [GO:0042995]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; presynaptic membrane [GO:0042734] carboxy-lyase activity [GO:0016831]; pyridoxal phosphate binding [GO:0030170] IKPLLPPK 27.75 0.003109187 905.8330658 0 18.57949 16.20953 18.52009 18.24433 A0A8C0NMQ3 A0A8C0NMQ3_CANLF Glutamate decarboxylase like 1 Canis lupus familiaris (Dog) (Canis familiaris) carboxylic acid metabolic process [GO:0019752] carboxy-lyase activity [GO:0016831]; pyridoxal phosphate binding [GO:0030170] GAAMSR 2.319999933 0.387050404 609.6832774 15.80508 15.71052 14.86742 15.17579 13.67441 A0A8C0Q732 A0A8C0Q732_CANLF Glutamate receptor GRIK3 Canis lupus familiaris (Dog) (Canis familiaris) postsynaptic membrane [GO:0045211] ligand-gated monoatomic ion channel activity [GO:0015276]; signaling receptor activity [GO:0038023] EAQWEGLTGR 13.44999981 0 1147.034613 14.20986 10.44071 13.39286 11.36354 13.43419 A0A8C0SUH3 A0A8C0SUH3_CANLF Glutamate receptor GRIK4 Canis lupus familiaris (Dog) (Canis familiaris) postsynaptic membrane [GO:0045211] ligand-gated monoatomic ion channel activity [GO:0015276]; signaling receptor activity [GO:0038023] TASTALLR 7.170000076 0.115637384 831.4711381 0 14.67778 16.08309 16.86643 14.14446 A0A8C0NFH9 A0A8C0NFH9_CANLF Glutamate receptor Canis lupus familiaris (Dog) (Canis familiaris) postsynaptic membrane [GO:0045211] ligand-gated monoatomic ion channel activity [GO:0015276]; signaling receptor activity [GO:0038023] TDGLRK 10.03999996 0.067895392 686.3601088 12.8182 15.46252 13.87629 16.23355 14.10635 Q5R1P3 NMDE2_CANLF "Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B)" GRIN2B Canis lupus familiaris (Dog) (Canis familiaris) "calcium ion transmembrane import into cytosol [GO:0097553]; excitatory postsynaptic potential [GO:0060079]; long-term synaptic potentiation [GO:0060291]; protein heterotetramerization [GO:0051290]; synaptic transmission, glutamatergic [GO:0035249]" cytoskeleton [GO:0005856]; late endosome [GO:0005770]; lysosome [GO:0005764]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839] glutamate binding [GO:0016595]; glutamate-gated calcium ion channel activity [GO:0022849]; NMDA glutamate receptor activity [GO:0004972]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; zinc ion binding [GO:0008270] ARPDFR 4.099999905 0.000314644 762.4175436 0 14.82407 16.13318 0 13.98886 A0A8C0SRG8 A0A8C0SRG8_CANLF Glutamate rich 6B ERICH6B Canis lupus familiaris (Dog) (Canis familiaris) LAMLILSTK 5.099999905 1.22E-13 990.8012107 14.26446 18.34893 12.28019 13.85621 12.60703 A0A8I3RSA3 A0A8I3RSA3_CANLF Glutathione S-transferase (EC 2.5.1.18) LOC479912 Canis lupus familiaris (Dog) (Canis familiaris) glutathione metabolic process [GO:0006749]; long-chain fatty acid biosynthetic process [GO:0042759]; nitrobenzene metabolic process [GO:0018916]; xenobiotic catabolic process [GO:0042178] cytosol [GO:0005829]; intercellular bridge [GO:0045171] enzyme binding [GO:0019899]; glutathione binding [GO:0043295]; glutathione transferase activity [GO:0004364]; leukotriene-C4 synthase activity [GO:0004464]; protein homodimerization activity [GO:0042803] AGAEGAEPR 23.54999924 0.293421876 856.1338562 15.51617 15.10481 13.51396 15.79109 15.74151 Q9TRK8 Q9TRK8_CANLF Glutathione S-transferase isozyme (EC 2.5.1.18) Canis lupus familiaris (Dog) (Canis familiaris) glutathione transferase activity [GO:0004364] XEAMRM 2.380000114 0.256099837 767.1692235 19.72965 21.77534 18.00403 17.52641 18.49057 A0A8C0SS58 A0A8C0SS58_CANLF Glutathione reductase (EC 1.8.1.7) GSR Canis lupus familiaris (Dog) (Canis familiaris) cell redox homeostasis [GO:0045454]; glutathione metabolic process [GO:0006749] cytoplasm [GO:0005737] flavin adenine dinucleotide binding [GO:0050660]; glutathione-disulfide reductase (NADP) activity [GO:0004362]; NADP binding [GO:0050661] MALLPR 2 0.138327849 717.0997724 16.97919 16.97236 15.20771 16.94543 17.69665 A0A8C0NDX9 A0A8C0NDX9_CANLF Glycogen [starch] synthase (EC 2.4.1.11) GYS1 Canis lupus familiaris (Dog) (Canis familiaris) glycogen biosynthetic process [GO:0005978]; heart development [GO:0007507] cytosol [GO:0005829]; inclusion body [GO:0016234] "glycogen (starch) synthase activity [GO:0004373]; glycogen synthase activity, transferring glucose-1-phosphate [GO:0061547]" TLDSMNSK 1.039999962 0.318202335 911.9746777 16.24572 15.06363 14.96936 14.50256 13.56772 A0A8C0NUS8 A0A8C0NUS8_CANLF Glycosyltransferase 2-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) VDQSLVLYR 4.550000191 0.159650216 1092.660042 12.38997 17.19293 14.71013 14.73506 11.17853 A0A8C0P8L2 A0A8C0P8L2_CANLF Growth arrest specific 2 GAS2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] microtubule binding [GO:0008017] FKEGMDANKPPK 5.809999943 0.105755516 1377.843561 18.3465 15.87266 16.61295 15.21066 16.32284 A0A8C0P6U0 A0A8C0P6U0_CANLF Growth hormone regulated TBC protein 1 GRTP1 Canis lupus familiaris (Dog) (Canis familiaris) MEPEGR 6.610000134 0 719.3087034 15.92646 17.60639 15.71904 0 0 A0A8I3MAD7 A0A8I3MAD7_CANLF Guanine nucleotide-binding protein G(o) subunit alpha GNAO1 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188] membrane [GO:0016020] G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] THPAPHPTLRR 3.799999952 0.241399827 1282.75479 12.67302 10.02947 13.50598 11.66225 12.29425 A0A8P0NEB1 A0A8P0NEB1_CANLF "Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase)" HDDC3 Canis lupus familiaris (Dog) (Canis familiaris) GSGGRGSGGR 3.279999971 0.385011963 846.7490045 15.93498 17.67861 15.31835 16.22813 15.6849 A0A8C0RQB1 A0A8C0RQB1_CANLF Guanylate cyclase (EC 4.6.1.2) GUCY2F Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; visual perception [GO:0007601] membrane [GO:0016020] ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; protein kinase activity [GO:0004672] IGVVGPWACDPLFSKALPEVAAR 1.080000043 0 2454.376399 11.9123 16.76293 9.380942 0 11.62868 A0A8C0PM55 A0A8C0PM55_CANLF H(+)-transporting two-sector ATPase (EC 7.1.2.2) ATP6V1A Canis lupus familiaris (Dog) (Canis familiaris) ATP metabolic process [GO:0046034] "clathrin-coated vesicle membrane [GO:0030665]; proton-transporting V-type ATPase, V1 domain [GO:0033180]" "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]" FKDPVK 1.419999957 0.239931727 732.1741467 12.15613 14.3848 16.53835 14.34129 15.31837 A0A8C0PUV7 A0A8C0PUV7_CANLF HAUS augmin like complex subunit 5 Canis lupus familiaris (Dog) (Canis familiaris) centrosome cycle [GO:0007098]; spindle assembly [GO:0051225] HAUS complex [GO:0070652] EQILTR 18.01000023 0.26590753 759.6414284 17.11401 0 19.82276 21.22078 19.91367 A0A8C0SCP6 A0A8C0SCP6_CANLF HECT-type E3 ubiquitin transferase (EC 2.3.2.26) AREL1 Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-protein transferase activity [GO:0004842] NILAATFIR 28.76000023 0 1018.826222 15.27693 0 16.61163 16.7414 17.04834 A0A8I3P005 A0A8I3P005_CANLF HECT-type E3 ubiquitin transferase (EC 2.3.2.26) HERC2 Canis lupus familiaris (Dog) (Canis familiaris) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737] ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] TIADFR 9.239999771 0.31522942 722.6879409 15.73866 16.66945 15.26282 16.20619 15.03408 A0A8C0S6R1 A0A8C0S6R1_CANLF HIT-type domain-containing protein ZNHIT6 Canis lupus familiaris (Dog) (Canis familiaris) box C/D snoRNP assembly [GO:0000492]; protein complex oligomerization [GO:0051259]; snoRNA localization [GO:0048254] pre-snoRNP complex [GO:0070761] ATPase binding [GO:0051117]; identical protein binding [GO:0042802]; TFIID-class transcription factor complex binding [GO:0001094] SGQKAEEMR 9.100000381 0 1036.397223 11.21469 12.93208 9.489009 11.65951 13.28455 A0A8C0QBL7 A0A8C0QBL7_CANLF HMG box domain-containing protein HMGXB4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] LILSPKEK 9.319999695 0.051209005 927.6685797 14.95257 17.29958 15.96643 16.48437 15.99473 A0A8C0PFH4 A0A8C0PFH4_CANLF HMG box domain-containing protein SOX6 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] MREQIQR 5.46999979 0.175295424 976.9689269 0 14.64208 16.29327 12.59805 14.60375 A0A8C0MX00 A0A8C0MX00_CANLF HMG box domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DNA metabolic process [GO:0006259]; innate immune response [GO:0045087] chromosome [GO:0005694]; nucleus [GO:0005634] "DNA binding, bending [GO:0008301]" WKTMSGK 9.159999847 0.01060107 851.313409 17.82974 19.16155 18.83547 19.70848 19.2254 A0A8C0QAP0 A0A8C0QAP0_CANLF HORMA domain-containing protein MAD2L1 Canis lupus familiaris (Dog) (Canis familiaris) DWTTGVR 8 0.291200743 835.5920705 15.33907 16.40818 15.12763 16.09619 14.5777 A0A8C0SYH7 A0A8C0SYH7_CANLF HYDIN axonemal central pair apparatus protein HYDIN Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] LQGNEK 16.01000023 0.069439716 688.3837221 15.19812 11.00372 0 13.85781 18.17051 A0A8C0SVU6 A0A8C0SVU6_CANLF HYLS1 centriolar and ciliosis associated HYLS1 Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030] centriole [GO:0005814]; centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ASVTPGK 1.409999967 0.253892721 659.8154192 14.422 15.61239 16.1102 17.03038 15.51393 P19006 HPT_CANLF Haptoglobin [Cleaved into: Haptoglobin alpha chain; Haptoglobin beta chain] HP Canis lupus familiaris (Dog) (Canis familiaris) acute-phase response [GO:0006953]; defense response to bacterium [GO:0042742]; immune system process [GO:0002376] extracellular space [GO:0005615] antioxidant activity [GO:0016209]; hemoglobin binding [GO:0030492]; serine-type endopeptidase activity [GO:0004252] GSFPWQAK 31.70999908 0.998193546 921.6349519 18.81819 0 17.61558 18.3704 19.21729 A0A8I3N0U0 A0A8I3N0U0_CANLF Hemogen HEMGN Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154] GGEGDGSAPER 4.46999979 0.081418211 1030.435014 13.22429 12.33135 16.12141 13.0469 14.86698 A0A8C0RFV7 A0A8C0RFV7_CANLF Heterogeneous nuclear ribonucleoprotein H2 (Heterogeneous nuclear ribonucleoprotein H') HNRNPH2 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904] RNA binding [GO:0003723] MMLSTEGREGFVVK 7.929999828 0.474711708 1600.16273 17.07559 16.6152 17.8531 0 0 A0A8C0PNQ1 A0A8C0PNQ1_CANLF Heterogeneous nuclear ribonucleoprotein K HNRNPK Canis lupus familiaris (Dog) (Canis familiaris) "negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902165]; regulation of low-density lipoprotein particle clearance [GO:0010988]; RNA splicing [GO:0008380]" catalytic step 2 spliceosome [GO:0071013]; chromatin [GO:0000785]; cytoplasmic stress granule [GO:0010494]; nucleoplasm [GO:0005654]; podosome [GO:0002102] DNA binding [GO:0003677]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723] GRPGDR 8.960000038 0.159318622 657.2955318 16.50558 15.33179 15.16778 14.872 14.84925 Q257A0 Q257A0_CANLF Hexosyltransferase (EC 2.4.1.-) b3galt6 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] hexosyltransferase activity [GO:0016758] DTWNAAGR 7.349999905 0.203925122 889.4542142 13.79444 13.62146 15.22844 15.72495 15.58883 A0A8C0LTW2 A0A8C0LTW2_CANLF HhH-GPD domain-containing protein NTHL1 Canis lupus familiaris (Dog) (Canis familiaris) base-excision repair [GO:0006284] "DNA binding [GO:0003677]; hydrolase activity, acting on glycosyl bonds [GO:0016798]" GQPGAEGPRR 5.840000153 0.150148993 1025.36609 13.67361 14.92683 15.22149 12.91179 18.11487 A0A8C0RJZ5 A0A8C0RJZ5_CANLF Histone H2A/H2B/H3 domain-containing protein LOC611989 Canis lupus familiaris (Dog) (Canis familiaris) nucleosome [GO:0000786] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] VHPDIGISSK 2.569999933 0.250859859 1053.370427 17.69399 16.69613 14.56682 15.88674 14.86587 A0A8I3MTB6 A0A8I3MTB6_CANLF Histone deacetylase (EC 3.5.1.98) HDAC9 Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to insulin stimulus [GO:0032869]; cholesterol homeostasis [GO:0042632]; negative regulation of cytokine production [GO:0001818]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]" cytoplasm [GO:0005737]; histone deacetylase complex [GO:0000118]; transcription regulator complex [GO:0005667] histone deacetylase binding [GO:0042826]; histone H4K16 deacetylase activity [GO:0034739]; metal ion binding [GO:0046872]; protein kinase C binding [GO:0005080]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] MVAVPR 1.149999976 0.370131908 671.7881456 16.87858 17.73227 15.72758 15.60469 15.99505 A0A8C0MH36 A0A8C0MH36_CANLF Histone-lysine N-methyltransferase (EC 2.1.1.364) KMT2B Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259]; regulation of DNA-templated transcription [GO:0006355] histone methyltransferase complex [GO:0035097] DNA binding [GO:0003677]; histone H3K4 methyltransferase activity [GO:0042800]; zinc ion binding [GO:0008270] GGRGSGAER 9.989999771 0.292537826 846.1355072 0 14.68427 16.724 15.19588 16.68963 A0A8I3MZ89 A0A8I3MZ89_CANLF Homeobox domain-containing protein LOC100683783 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] SFSQPMRWK 6.21999979 0.230679685 1167.104396 15.13551 14.20861 14.96587 15.37024 14.221 A0A8C0NZC3 A0A8C0NZC3_CANLF Homeobox domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" MAAPSLR 3.619999886 0.137851821 761.1158008 15.58664 17.13319 15.9737 15.73198 0 A0A8C0NUZ1 A0A8C0NUZ1_CANLF Homeobox protein Hox-D4 HOXD4 Canis lupus familiaris (Dog) (Canis familiaris) anterior/posterior pattern specification [GO:0009952]; embryonic skeletal system morphogenesis [GO:0048704]; stem cell differentiation [GO:0048863] cell junction [GO:0030054]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" MAMSSYMVNSK 4.150000095 0.269579404 1265.461659 17.16219 17.60755 0 19.44642 18.24807 A0A8C0ME41 A0A8C0ME41_CANLF HotDog ACOT-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) coenzyme A biosynthetic process [GO:0015937]; long-chain fatty-acyl-CoA catabolic process [GO:0036116]; medium-chain fatty acid biosynthetic process [GO:0051792]; medium-chain fatty-acyl-CoA catabolic process [GO:0036114]; palmitic acid biosynthetic process [GO:1900535] cytosol [GO:0005829]; nucleoplasm [GO:0005654] carboxylic ester hydrolase activity [GO:0052689]; long-chain fatty acyl-CoA binding [GO:0036042]; palmitoyl-CoA hydrolase activity [GO:0016290]; protein homodimerization activity [GO:0042803] QGRAEPQP 4.380000114 0.036821299 881.46481 0 14.7583 13.13906 0 16.19815 A0A8C0PVE5 A0A8C0PVE5_CANLF Hyaluronan mediated motility receptor HMMR LOC100855768 Canis lupus familiaris (Dog) (Canis familiaris) hyaluronan catabolic process [GO:0030214]; receptor-mediated endocytosis [GO:0006898] centrosome [GO:0005813]; cytosol [GO:0005829]; spindle [GO:0005819] cargo receptor activity [GO:0038024]; hyaluronic acid binding [GO:0005540] ENFGLK 5.239999771 0.368788166 707.5865263 18.39865 17.11385 15.44789 16.38842 17.9704 A0A8C0RLP2 A0A8C0RLP2_CANLF Hydroxysteroid 11-beta dehydrogenase 1 HSD11B1 Canis lupus familiaris (Dog) (Canis familiaris) TRSSGSTK 4.869999886 0.301110749 824.0141374 19.39889 17.21837 16.3632 14.69092 15.90032 A0A8C0Q045 A0A8C0Q045_CANLF Hydroxysteroid 17-beta dehydrogenase 14 HSD17B14 NTN5 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] SLWRRPAWPGALGGPEK 1.169999957 0 1877.40043 15.72057 12.93154 14.44546 0 14.77906 A0A8I3PXZ5 A0A8I3PXZ5_CANLF Hyperpolarization activated cyclic nucleotide gated potassium channel 4 HCN4 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to cAMP [GO:0071320]; cellular response to cGMP [GO:0071321]; potassium ion import across plasma membrane [GO:1990573]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane depolarization [GO:0003254]; sodium ion import across plasma membrane [GO:0098719] HCN channel complex [GO:0098855]; perinuclear region of cytoplasm [GO:0048471] identical protein binding [GO:0042802]; intracellular cAMP-activated cation channel activity [GO:0005222]; voltage-gated potassium channel activity involved in SA node cell action potential depolarization [GO:0086041]; voltage-gated sodium channel activity [GO:0005248] GSLASLGSR 6.289999962 1.22E-13 846.4078528 12.38714 9.890153 12.49134 12.93919 13.43175 A0A8C0M9F9 A0A8C0M9F9_CANLF Hypoxia inducible factor 3 subunit alpha HIF3A Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] protein dimerization activity [GO:0046983] SSTELRK 7.940000057 0.159418522 821.8211231 19.89986 19.38231 18.22809 20.57022 16.89865 A0A8C0NQ03 A0A8C0NQ03_CANLF ILEI/PANDER domain-containing protein FAM3D Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; membrane [GO:0016020] TIRLPR 7.320000172 0.089892368 755.2715442 16.16695 14.44367 15.50455 16.38391 15.3574 A0A8C0RTN4 A0A8C0RTN4_CANLF INSC spindle orientation adaptor protein Canis lupus familiaris (Dog) (Canis familiaris) asymmetric cell division [GO:0008356] MALPGGR 5.900000095 0.170119442 718.4337092 16.60457 16.40845 18.14046 16.05747 16.03894 A0A8C0PKX6 A0A8C0PKX6_CANLF IPT/TIG domain-containing protein EBF3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] TGPAAPGAR 6.269999981 0.222132013 798.052651 15.57894 0 16.13516 16.57084 15.44382 A0A8C0RAA7 A0A8C0RAA7_CANLF IQ motif containing GTPase activating protein 1 IQGAP1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane bounded cell projection [GO:0120025] LTELGTVDPK 2.069999933 0.277750841 1073.286983 14.90511 14.33531 13.85997 15.86577 16.00133 A0A8C0MH66 A0A8C0MH66_CANLF IRF tryptophan pentad repeat domain-containing protein IRF4 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; transcription cis-regulatory region binding [GO:0000976] RGGGAGGGWR 3.920000076 0.256831971 929.9145718 15.40158 15.51112 13.77383 17.20919 15.03054 A0A8C0N2J3 A0A8C0N2J3_CANLF IRF tryptophan pentad repeat domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; transcription cis-regulatory region binding [GO:0000976] EVTEPACR 10.61999989 0.32325933 961.9885493 14.33521 0 12.19919 16.29404 14.2227 A0A8C0N6W2 A0A8C0N6W2_CANLF Ig-like domain-containing protein CILP2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] ASGTPVPK 5.539999962 0.001995173 755.3134692 14.02733 15.71251 12.50087 16.40645 16.10858 A0A8C0M5B1 A0A8C0M5B1_CANLF Ig-like domain-containing protein FCRL1 Canis lupus familiaris (Dog) (Canis familiaris) B cell activation [GO:0042113] cell surface [GO:0009986]; membrane [GO:0016020] coreceptor activity [GO:0015026] GALGLNLETK 10 0.189634802 1015.857647 0 0 10.46004 12.37271 14.56757 A0A8C0PFW5 A0A8C0PFW5_CANLF Ig-like domain-containing protein ICOSLG Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VDVIPTR 4.590000153 0.199687705 799.0424833 16.20328 15.26795 14.25615 16.54861 15.59603 A0A8C0T2M8 A0A8C0T2M8_CANLF Ig-like domain-containing protein IGSF8 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EGAERYR 1.159999967 0.246366265 879.9394281 14.99968 15.85717 13.8121 14.44605 14.3315 A0A8C0PSK6 A0A8C0PSK6_CANLF Ig-like domain-containing protein LOC102152131 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] carbohydrate binding [GO:0030246] GGKSASCN 3.589999914 0.377208687 781.000224 16.39323 14.81534 14.81601 15.33998 15.44429 A0A8I3ME01 A0A8I3ME01_CANLF Ig-like domain-containing protein VSTM2B Canis lupus familiaris (Dog) (Canis familiaris) GAAPGPEPGEGGR 3.410000086 0 1151.501039 10.34582 0 10.28052 10.9438 0 A0A8C0N6P9 A0A8C0N6P9_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AQASAGGRAAGPIPPLGR 2.359999895 2.46E-13 1646.010217 14.87861 15.611 0 14.21055 16.08381 A0A8C0P0P9 A0A8C0P0P9_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LCSAGGPLK 2.549999952 0.3133995 901.3271026 15.50091 16.23831 12.5114 15.07248 15.10298 A0A8C0SM52 A0A8C0SM52_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LINLVSNR 17.37999916 0.235950103 929.8419769 18.50882 16.6304 16.66949 0 15.93019 A0A8C0MSS4 A0A8C0MSS4_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250] immunoglobulin complex [GO:0019814] NTCICR 6.079999924 0.286371823 824.0642167 15.04142 15.32491 15.19016 14.57876 16.67849 A0A8C0PHD3 A0A8C0PHD3_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) YGSTHTMQML 5.460000038 0.111538634 1200.373708 11.3488 12.5044 14.21961 14.45424 12.35565 A0A8C0PAY0 A0A8C0PAY0_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EIKPSSK 7.599999905 0.349917632 788.7671451 16.38569 18.39697 0 16.13938 14.80665 A0A8C0NYX0 A0A8C0NYX0_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ADGSPVTQGVETTKPSK 78.66000366 0.015166329 1702.018364 18.45376 19.89467 17.77068 0 19.79643 A0A8C0SY63 A0A8C0SY63_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ADGSPITQGVETTKPSK 58.81999969 0.505324277 1716.210661 19.42052 19.51076 17.68209 19.17642 18.74108 A0A8I3NS90 A0A8I3NS90_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) TKVDKPVLK 44.29999924 0.557109163 1027.541262 11.6606 13.82492 16.83121 15.57362 17.35554 A0A8C0Q0U8 A0A8C0Q0U8_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VVSVLPIGHQDWLKGK 31.38999939 0.504651406 1776.264406 19.96366 0 18.27456 0 0 A0A8C0MUQ0 A0A8C0MUQ0_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LPAGALR 10.10000038 0.267709181 697.7993001 16.86914 16.15882 16.05432 18.1728 16.51273 A0A8C0P281 A0A8C0P281_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] TDTPKAGR 18.55999947 0.093847216 846.3122687 15.8982 14.53313 16.61195 14.72493 16.37213 A0A8C0P0J5 A0A8C0P0J5_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DNVTNGMATLIIAVDRK 4.269999981 0 1831.003826 14.19628 12.77932 13.8116 15.58399 11.27311 A0A8C0RYW4 A0A8C0RYW4_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ILGTGK 8.659999847 0.310665915 588.3305528 16.30387 18.45154 14.39625 15.73501 16.61919 A0A8P0NMW4 A0A8P0NMW4_CANLF Immunoglobulin V-set domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GLEATNDRSSR 8.75 0.061992381 1206.559307 0 17.37268 15.10142 14.86671 15.41898 A0A8C0N4I8 A0A8C0N4I8_CANLF Immunoglobulin superfamily member 10 IGSF10 Canis lupus familiaris (Dog) (Canis familiaris) regulation of neuron migration [GO:2001222] extracellular region [GO:0005576] TLSSAKSK 3.140000105 0.315328874 821.892673 0 15.21602 14.93353 16.35587 15.66462 A0A8C0Z5Z3 A0A8C0Z5Z3_CANLF Immunoglobulin superfamily member 22 IGSF22 Canis lupus familiaris (Dog) (Canis familiaris) SHMVVR 6.539999962 0.233260051 745.4462098 16.31055 16.20439 15.34329 16.41689 16.36219 A0A8C0S4M3 A0A8C0S4M3_CANLF Immunoglobulin superfamily member 9B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GLEGPGGLEGR 3.019999981 0.355886921 1042.387731 16.05623 16.4493 16.10525 18.32802 15.32925 A0A8I3Q2W2 A0A8I3Q2W2_CANLF Importin subunit alpha KPNA4 Canis lupus familiaris (Dog) (Canis familiaris) dopamine secretion [GO:0014046]; gene expression [GO:0010467]; protein import into nucleus [GO:0006606] cytoplasm [GO:0005737]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654] nuclear import signal receptor activity [GO:0061608] SSAQDLTR 2.769999981 2.43E-13 876.29689 17.95369 12.93782 9.362251 14.26013 14.28566 A0A8I3NDI1 A0A8I3NDI1_CANLF Inhibitor of Bruton tyrosine kinase IBTK Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of protein phosphorylation [GO:0001933]; release of sequestered calcium ion into cytosol [GO:0051209] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] protein kinase binding [GO:0019901]; protein tyrosine kinase inhibitor activity [GO:0030292] MIPAMDR 1.659999967 0.170451861 850.5068449 15.76775 17.73851 0 14.22008 16.48576 A0A8C0LWG1 A0A8C0LWG1_CANLF Inhibitory synaptic factor family member 2B Canis lupus familiaris (Dog) (Canis familiaris) SQKAGGFR 1.970000029 0.26454886 850.7867297 14.67518 16.13723 15.05853 14.9463 15.06394 Q29467 I5P1_CANLF "Inositol polyphosphate-5-phosphatase A (EC 3.1.3.56) (Type I inositol 1,4,5-trisphosphate 5-phosphatase) (5PTase)" INPP5A Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [GO:1900737]; phosphatidylinositol dephosphorylation [GO:0046856] dendrite [GO:0030425]; plasma membrane [GO:0005886] "inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; inositol-polyphosphate 5-phosphatase activity [GO:0004445]" SESEEK 2.640000105 0.358394657 708.204765 13.17184 15.83337 14.44477 15.11053 15.17872 A0A8C0STH1 A0A8C0STH1_CANLF Integrator complex subunit 10 INTS10 Canis lupus familiaris (Dog) (Canis familiaris) snRNA processing [GO:0016180] integrator complex [GO:0032039] IHLELLPNQGMLIK 2.940000057 0.300314478 1635.893463 0 17.2716 17.60106 19.03755 17.09516 A0A8C0RF21 A0A8C0RF21_CANLF Integrator complex subunit 7 INTS7 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to ionizing radiation [GO:0071479]; DNA damage checkpoint signaling [GO:0000077]; snRNA processing [GO:0016180] chromosome [GO:0005694]; cytoplasm [GO:0005737]; integrator complex [GO:0032039]; nuclear body [GO:0016604] QSMEEFR 2.50999999 0.243313402 925.9786323 16.73923 15.75321 15.75996 17.00933 15.78282 A0A8C0N8T0 A0A8C0N8T0_CANLF Integrin subunit alpha 7 ITGA7 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] integrin complex [GO:0008305] GESAMKSER 5.420000076 0.247352335 1009.049801 14.07675 13.67491 16.44803 13.73408 14.82629 A0A8I3S4C3 A0A8I3S4C3_CANLF Interactor of little elongation complex ELL subunit 1 ICE1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of intracellular protein transport [GO:0090316]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of transcription by RNA polymerase III [GO:0045945]; snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796] Cajal body [GO:0015030]; euchromatin [GO:0000791]; histone locus body [GO:0035363]; transcription elongation factor complex [GO:0008023] protein-macromolecule adaptor activity [GO:0030674] SEHEQK 4.889999866 0.23646465 757.7160594 12.9037 15.36891 14.80502 13.12015 14.61917 B6E117 B6E117_CANLF Interferon gamma (IFN-gamma) IF2F IFN-gamma Canis lupus familiaris (Dog) (Canis familiaris) "astrocyte activation [GO:0048143]; defense response to virus [GO:0051607]; extrinsic apoptotic signaling pathway [GO:0097191]; macrophage activation involved in immune response [GO:0002281]; macrophage differentiation [GO:0030225]; microglial cell activation [GO:0001774]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of autophagy [GO:0010508]; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response [GO:0032834]; positive regulation of chemokine production [GO:0032722]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of fructose 1,6-bisphosphate metabolic process [GO:0060552]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of killing of cells of another organism [GO:0051712]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of neurogenesis [GO:0050769]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; positive regulation of protein deacetylation [GO:0090312]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of smooth muscle cell apoptotic process [GO:0034393]; positive regulation of tumor necrosis factor (ligand) superfamily member 11 production [GO:2000309]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of vitamin D biosynthetic process [GO:0060557]; regulation of insulin secretion [GO:0050796]; type II interferon-mediated signaling pathway [GO:0060333]; type III interferon-mediated signaling pathway [GO:0038196]" extracellular space [GO:0005615] cytokine activity [GO:0005125]; type II interferon receptor binding [GO:0005133] EDMLGK 8.18999958 0.062276878 708.4515044 14.71276 15.87171 16.93261 14.24521 15.1158 A0A8C0Q8R3 A0A8C0Q8R3_CANLF Interleukin 12 receptor subunit beta 2 IL12RB2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EFCLPGK 4.150000095 0.246572289 851.3895104 17.57341 16.48307 17.88946 14.11624 17.76939 A0A8C0PGB6 A0A8C0PGB6_CANLF Interleukin 17 receptor B IL17RB Canis lupus familiaris (Dog) (Canis familiaris) intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] interleukin-17 receptor activity [GO:0030368] ADASIRLLK 3.440000057 0.227827288 986.7396297 17.46021 14.11113 13.89152 0 14.67395 A0A8C0Q7W0 A0A8C0Q7W0_CANLF Interleukin 23 receptor IL23R Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of interleukin-10 production [GO:0032693]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of type II interferon production [GO:0032729]; response to lipopolysaccharide [GO:0032496]; response to type II interferon [GO:0034341] interleukin-23 receptor complex [GO:0072536] interleukin-12 receptor binding [GO:0005143]; interleukin-23 binding [GO:0042019]; interleukin-23 receptor activity [GO:0042020] ILLLIPK 34.63000107 0.10575037 810.6159671 15.67634 13.24763 0 13.93677 0 A0A8C0SAR0 A0A8C0SAR0_CANLF Interleukin 3 receptor subunit alpha IL3RA Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] cytokine receptor activity [GO:0004896] TASPDARSSGR 3.109999895 0.300113585 1104.215349 0 14.16339 14.92968 14.16285 15.52055 A0A8I3QPC9 A0A8I3QPC9_CANLF Interleukin 6 cytokine family signal transducer IL6ST Canis lupus familiaris (Dog) (Canis familiaris) glycogen metabolic process [GO:0005977]; interleukin-27-mediated signaling pathway [GO:0070106]; intestinal epithelial cell development [GO:0060576]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531] ciliary neurotrophic factor receptor complex [GO:0070110]; dendrite [GO:0030425]; external side of plasma membrane [GO:0009897]; interleukin-6 receptor complex [GO:0005896]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; oncostatin-M receptor complex [GO:0005900] ciliary neurotrophic factor receptor binding [GO:0005127]; coreceptor activity [GO:0015026]; identical protein binding [GO:0042802]; interleukin-11 binding [GO:0019970]; interleukin-11 receptor activity [GO:0004921]; interleukin-6 binding [GO:0019981]; interleukin-6 receptor activity [GO:0004915]; interleukin-6 receptor binding [GO:0005138]; leukemia inhibitory factor receptor activity [GO:0004923]; oncostatin-M receptor activity [GO:0004924]; protein tyrosine kinase activator activity [GO:0030296]; scaffold protein binding [GO:0097110] KPFPEDLK 13.23999977 0.303979781 972.972664 12.44245 14.40909 12.84106 16.58736 15.45053 A0A8P0P172 A0A8P0P172_CANLF Interleukin 6 cytokine family signal transducer IL6ST Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] cytokine receptor activity [GO:0004896] RGGYMPQ 4.96999979 0.051121373 824.5333958 12.87887 16.62454 13.69383 0 16.74865 A0A8C0PH49 A0A8C0PH49_CANLF Intraflagellar transport 81 IFT81 Canis lupus familiaris (Dog) (Canis familiaris) intraciliary transport involved in cilium assembly [GO:0035735]; regulation of smoothened signaling pathway [GO:0008589]; sperm flagellum assembly [GO:0120316] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; intraciliary transport particle B [GO:0030992]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228] tubulin binding [GO:0015631] GRTLDDMSEMVK 4.900000095 0.060421065 1397.247237 14.45211 16.10844 12.81622 13.89917 14.25079 A0A8C0P3B3 A0A8C0P3B3_CANLF Intraflagellar transport protein 122 homolog IFT122 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271] cilium [GO:0005929] IDDPSP 2.039999962 0.267929587 642.6401336 15.68219 15.1043 15.67667 14.38444 15.05076 Q6JAN1 INVS_CANLF Inversin (Inversion of embryo turning protein) (Nephrocystin-2) INVS INV NPHP2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of canonical Wnt signaling pathway [GO:0090090]; protein localization to ciliary inversin compartment [GO:1904108]; Wnt signaling pathway [GO:0016055] ciliary inversin compartment [GO:0097543]; cytoplasm [GO:0005737]; membrane [GO:0016020]; microtubule [GO:0005874]; nucleus [GO:0005634]; spindle [GO:0005819] calmodulin binding [GO:0005516] HLSHLLHMK 3.839999914 0 1132.723546 10.61604 13.90538 12.14095 9.721328 12.24515 A0A8C0MC85 A0A8C0MC85_CANLF Inverted formin 2 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036] actin binding [GO:0003779]; small GTPase binding [GO:0031267] SFTEER 2.119999886 0.122073872 767.5780055 14.50532 13.15061 14.27573 15.15365 15.30137 A0A8C0QAE6 A0A8C0QAE6_CANLF Ion transport domain-containing protein CACNA1H Canis lupus familiaris (Dog) (Canis familiaris) voltage-gated calcium channel complex [GO:0005891] voltage-gated calcium channel activity [GO:0005245] GTGGRGRPR 4.409999847 0.317150146 912.9965678 17.76803 15.16626 15.89365 14.317 15.2426 A0A8C0QG13 A0A8C0QG13_CANLF Ion transport domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) lysosomal membrane [GO:0005765] monoatomic ion channel activity [GO:0005216]; voltage-gated channel activity [GO:0022832] AGSCSPGRVR 4.340000153 0.17909835 1045.499641 17.14666 11.67802 15.09911 13.32977 0 A0A8C0MSG6 A0A8C0MSG6_CANLF Iron-responsive element-binding protein 2 IREB2 Canis lupus familiaris (Dog) (Canis familiaris) erythrocyte homeostasis [GO:0034101]; establishment of localization in cell [GO:0051649]; intestinal absorption [GO:0050892]; intracellular iron ion homeostasis [GO:0006879]; multicellular organismal-level iron ion homeostasis [GO:0060586]; osteoclast differentiation [GO:0030316]; post-embryonic development [GO:0009791]; protoporphyrinogen IX biosynthetic process [GO:0006782]; regulation of translation [GO:0006417] cytosol [GO:0005829] "4 iron, 4 sulfur cluster binding [GO:0051539]; iron-responsive element binding [GO:0030350]; metal ion binding [GO:0046872]" YGSGNSR 5.670000076 0.349726105 739.9146269 17.10526 15.63025 15.95597 14.86549 15.90189 A0A8C0LZ52 A0A8C0LZ52_CANLF Isochorismatase-like domain-containing protein ISOC2 Canis lupus familiaris (Dog) (Canis familiaris) MATMRSNLGR 3.819999933 2.49E-13 1152.805968 17.44255 0 0 12.62814 13.59202 A0A8C0MJ75 A0A8C0MJ75_CANLF J domain-containing protein DNAJC11 Canis lupus familiaris (Dog) (Canis familiaris) LILTEASK 6.070000172 0.313513228 872.2505868 16.51985 15.981 18.25855 14.99365 15.41754 A0A8C0LR00 A0A8C0LR00_CANLF JNK1/MAPK8 associated membrane protein JKAMP Canis lupus familiaris (Dog) (Canis familiaris) response to unfolded protein [GO:0006986] membrane [GO:0016020] MGGETERTR 1.029999971 0.030591779 1051.279761 17.29944 13.47389 15.32642 16.3299 12.80863 A0A8C0QGZ3 A0A8C0QGZ3_CANLF Janus kinase and microtubule-interacting protein C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) kinase binding [GO:0019900]; microtubule binding [GO:0008017] IAELNATIRK 1.409999967 0.327511906 1128.573413 16.72885 13.69077 12.62714 13.91083 14.10046 A0A8C0NI35 A0A8C0NI35_CANLF "Junction mediating and regulatory protein, p53 cofactor" JMY Canis lupus familiaris (Dog) (Canis familiaris) HVISQLDSIR 4.880000114 0.033553981 1167.394934 13.78512 15.40089 13.54753 16.06193 14.47346 A0A8C0PQ83 A0A8C0PQ83_CANLF K Homology domain-containing protein PCBP3 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] TLRGTG 1.769999981 0.030939902 605.3865551 14.92793 13.49521 16.26055 13.83432 13.08206 A0A8C0MEQ0 A0A8C0MEQ0_CANLF "KH domain-containing, RNA-binding, signal transduction-associated protein 2" KHDRBS2 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; mRNA processing [GO:0006397] nucleus [GO:0005634] RNA binding [GO:0003723]; SH3 domain binding [GO:0017124] GAPTVPGYR 4.570000172 0.277816917 917.6033687 10.05377 14.70183 12.42604 17.06144 15.38681 A0A8C0NJZ9 A0A8C0NJZ9_CANLF KIAA0319 like KIAA0319L Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] GESDMDR 3.309999943 0.273188241 826.5075474 14.81164 16.30249 14.81161 13.77976 13.0308 A0A8C0MUQ5 A0A8C0MUQ5_CANLF KIAA0825 Canis lupus familiaris (Dog) (Canis familiaris) FLSQLIKSFLELEK 2 4.86E-13 1695.803925 14.94537 16.09114 14.32638 14.84919 15.69446 A0A8C0TC08 A0A8C0TC08_CANLF KIAA1522 KIAA1522 Canis lupus familiaris (Dog) (Canis familiaris) GNSHHKR 8.06000042 0.393865902 836.2625951 15.34033 0 15.32909 14.47137 15.78915 A0A8I3ML51 A0A8I3ML51_CANLF "Kaptin, actin binding protein" KPTN Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015]; cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; negative regulation of TORC1 signaling [GO:1904262]; protein localization to lysosome [GO:0061462] filamentous actin [GO:0031941]; KICSTOR complex [GO:0140007]; lamellipodium [GO:0030027]; postsynaptic actin cytoskeleton [GO:0098871] actin filament binding [GO:0051015] VAHVDQR 3.869999886 0.004396248 824.8315271 16.81237 0 14.76955 16.08665 16.44067 A0A8C0M431 A0A8C0M431_CANLF Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin) KATNB1 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; microtubule severing [GO:0051013]; mitotic chromosome movement towards spindle pole [GO:0007079]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of microtubule depolymerization [GO:0031117] axon [GO:0030424]; centrosome [GO:0005813]; cytosol [GO:0005829]; katanin complex [GO:0008352]; microtubule [GO:0005874]; plasma membrane [GO:0005886]; spindle pole [GO:0000922] ATPase regulator activity [GO:0060590]; dynein complex binding [GO:0070840]; microtubule binding [GO:0008017]; protein heterodimerization activity [GO:0046982] AVWTTGDIK 6.710000038 0.059543637 990.4049285 15.64487 0 12.5658 14.39731 13.13981 A0A8P0NFU2 A0A8P0NFU2_CANLF Kelch domain containing 2 KLHDC2 Canis lupus familiaris (Dog) (Canis familiaris) GELEAGRSR 3 0.287047242 975.3964723 15.02987 13.51672 17.22585 16.10953 16.50266 A3RF35 A3RF35_CANLF Keratin 12 KRT12 Krt12 Canis lupus familiaris (Dog) (Canis familiaris) epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; morphogenesis of an epithelium [GO:0002009] cytoskeleton [GO:0005856]; intermediate filament [GO:0005882] structural molecule activity [GO:0005198] LLNNMR 15.35000038 0.214250414 776.6706715 17.50762 17.74586 21.06052 16.86856 16.87826 A0A8C0S955 A0A8C0S955_CANLF Keratin 15 KRT15 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] structural molecule activity [GO:0005198] VILEIDNAR 6.71999979 0.334466925 1043.922063 14.52328 12.68517 14.46645 16.84859 15.21274 Q6EIZ0 K1C10_CANLF "Keratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Epithelial keratin-10) (Keratin-10) (K10)" KRT10 KER10 Canis lupus familiaris (Dog) (Canis familiaris) epidermis development [GO:0008544]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; positive regulation of epidermis development [GO:0045684]; protein heterotetramerization [GO:0051290] cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular region [GO:0005576]; keratin filament [GO:0045095] protein heterodimerization activity [GO:0046982]; structural constituent of skin epidermis [GO:0030280] LAADDFR 11.72999954 0.261368004 807.9757518 16.04162 16.713 15.19407 13.53952 15.4297 A0A8C0NQU6 A0A8C0NQU6_CANLF "Keratin, type I cytoskeletal 20 (Cytokeratin-20) (Keratin-20)" KRT20 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to starvation [GO:0009267]; intermediate filament organization [GO:0045109]; regulation of protein secretion [GO:0050708] cytosol [GO:0005829]; intermediate filament [GO:0005882] structural molecule activity [GO:0005198] GYGGDHTK 5.880000114 0.052789882 834.7102698 12.17668 13.22528 12.76766 15.06906 13.33312 A0A8C0PGY0 A0A8C0PGY0_CANLF Kielin cysteine rich BMP regulator Canis lupus familiaris (Dog) (Canis familiaris) DGEEFEGPPGSCEWCR 1.840000033 0 1912.632941 11.3521 0 17.11531 0 11.036 A0A8C0TR47 A0A8C0TR47_CANLF Kinase non-catalytic C-lobe domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] GPAPQPR 4.420000076 0.300616386 723.7223559 19.02852 16.71879 0 16.40908 16.85449 A0A8C0TR05 A0A8C0TR05_CANLF Kinase non-catalytic C-lobe domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] TLLLDMAR 11.25 0.337179335 932.8450118 14.98779 15.29804 0 17.06628 0 A0A8I3P2I8 A0A8I3P2I8_CANLF Kinase suppressor of ras 1 KSR1 Canis lupus familiaris (Dog) (Canis familiaris) cAMP-mediated signaling [GO:0019933]; Ras protein signal transduction [GO:0007265]; regulation of cell population proliferation [GO:0042127] 14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524]; Hsp90 protein binding [GO:0051879]; MAP-kinase scaffold activity [GO:0005078]; metal ion binding [GO:0046872]; mitogen-activated protein kinase kinase binding [GO:0031434]; protein kinase activity [GO:0004672]; protein-folding chaperone binding [GO:0051087] MGSGAQGPR 6.800000191 0.266672563 876.9091693 14.57798 15.87182 13.48859 16.95071 16.71904 A0A8C0MGZ8 A0A8C0MGZ8_CANLF Kinesin family member 24 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] KEAVDLTQYILQVILK 7.860000134 0.185728259 1873.876777 15.3597 17.02263 0 0 0 A0A8C0P9D0 A0A8C0P9D0_CANLF Kinesin motor domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] RFQSTGK 7.409999847 0.283591519 824.2879504 17.06645 16.79293 18.90269 16.56334 16.10585 A0A8C0QE13 A0A8C0QE13_CANLF Kinesin-like protein KIF18A Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018]; organelle organization [GO:0006996] microtubule [GO:0005874]; spindle [GO:0005819] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] IPSHKR 3.069999933 0.239566455 736.4129606 16.96088 17.21953 17.51932 19.0715 17.24542 A0A8C0SM74 A0A8C0SM74_CANLF Kinesin-like protein KIF22 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018]; mitotic metaphase chromosome alignment [GO:0007080]; sister chromatid cohesion [GO:0007062] chromatin [GO:0000785]; cytosol [GO:0005829]; microtubule [GO:0005874]; mitotic spindle [GO:0072686]; nuclear speck [GO:0016607] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] NHQETLK 1 0 868.3078828 16.22403 17.42099 17.457 18.48171 0 A0A8C0NC53 A0A8C0NC53_CANLF Kinesin-like protein KIF3B Canis lupus familiaris (Dog) (Canis familiaris) anterograde dendritic transport of neurotransmitter receptor complex [GO:0098971]; cilium assembly [GO:0060271]; intraciliary transport [GO:0042073]; mitotic spindle assembly [GO:0090307]; opsin transport [GO:0036372]; vesicle-mediated transport [GO:0016192] centrosome [GO:0005813]; cilium [GO:0005929]; dendrite cytoplasm [GO:0032839]; kinesin II complex [GO:0016939]; microtubule [GO:0005874] ATP binding [GO:0005524]; intraciliary transport particle B binding [GO:0120170]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; small GTPase binding [GO:0031267] DLLSKDQTK 2.480000019 0.069363161 1045.571155 15.39484 14.23607 19.14823 16.47425 14.50042 A0A8C0LZ28 A0A8C0LZ28_CANLF Kremen protein (Kringle-containing protein marking the eye and the nose) KREMEN2 Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] plasma membrane [GO:0005886] AFDGSR 5.650000095 0.325843516 654.0180382 17.50089 15.77496 0 15.46706 0 A0A8C0PCN9 A0A8C0PCN9_CANLF L-lactate dehydrogenase (EC 1.1.1.27) LDHA Canis lupus familiaris (Dog) (Canis familiaris) carboxylic acid metabolic process [GO:0019752] cytoplasm [GO:0005737] L-lactate dehydrogenase activity [GO:0004459] RVHPISTMIK 1.480000019 2.43E-13 1196.906686 0 9.998083 0 0 12.24598 A0A8C0M262 A0A8C0M262_CANLF LDL receptor related protein associated protein 1 LRPAP1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783] heparin binding [GO:0008201]; low-density lipoprotein particle receptor binding [GO:0050750]; receptor antagonist activity [GO:0048019] NEPELPPK 23.04999924 0.08405586 922.7317139 17.79713 0 0 17.53198 16.18991 A0A8P0PFU3 A0A8P0PFU3_CANLF LHFPL tetraspan subfamily member 5 LHFPL5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LPRPGPGFPLPPPAR 4.690000057 0 1568.21663 0 0 18.42176 17.10454 19.05655 A0A8C0QKR0 A0A8C0QKR0_CANLF LIM domain 7 LMO7 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell adhesion [GO:0030155]; regulation of signaling [GO:0023051] metal ion binding [GO:0046872] QEGPGSRGGGHAPGGGAR 6.070000172 0.513652113 1602.926358 11.10603 15.63205 11.72477 14.52548 17.16336 A0A8C0M8K3 A0A8C0M8K3_CANLF LIM zinc-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] NQGLDGLFR 5.130000114 0.085307385 1020.70331 17.35621 15.61864 15.88589 12.59496 15.93783 A0A8I3NQT0 A0A8I3NQT0_CANLF LON peptidase N-terminal domain and ring finger 1 LONRF1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] metal ion binding [GO:0046872] FWEVGGGGGDRLER 5.739999771 0.13871177 1533.728662 17.6807 18.45148 14.38516 16.72869 16.11244 A0A8C0NBS8 A0A8C0NBS8_CANLF LPS responsive beige-like anchor protein Canis lupus familiaris (Dog) (Canis familiaris) LLSQTMK 9.68999958 0.328867027 820.3206393 20.37259 16.85571 21.43118 22.73117 21.22165 A0A8C0NCX2 A0A8C0NCX2_CANLF LRRC37A/B like protein 1 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SVHFGNPLLK 6.480000019 0 1110.81485 14.3737 13.1782 13.12896 11.44857 10.97649 A0A8C0M4H6 A0A8C0M4H6_CANLF LRRCT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) axonogenesis [GO:0007409]; regulation of presynapse assembly [GO:1905606] membrane [GO:0016020] GPALPK 3.119999886 0.364870606 582.7537645 18.42708 15.67248 19.6263 17.17519 18.12968 A0A8I3NU98 A0A8I3NU98_CANLF Lactate/malate dehydrogenase C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" GISTSQGLYGIK 3.480000019 0.203125766 1222.594517 12.99179 0 12.22139 13.89063 11.32079 A0A8C0TCD0 A0A8C0TCD0_CANLF Lamin A/C LMNA Canis lupus familiaris (Dog) (Canis familiaris) cellular response to hypoxia [GO:0071456]; cellular senescence [GO:0090398]; DNA double-strand break attachment to nuclear envelope [GO:1990683]; establishment or maintenance of microtubule cytoskeleton polarity [GO:0030951]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of mesenchymal cell proliferation [GO:0072201]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; nuclear envelope organization [GO:0006998]; positive regulation of gene expression [GO:0010628]; protein import into nucleus [GO:0006606]; regulation of cell migration [GO:0030334]; regulation of protein localization to nucleus [GO:1900180]; regulation of protein stability [GO:0031647]; ventricular cardiac muscle cell development [GO:0055015] lamin filament [GO:0005638]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; site of double-strand break [GO:0035861] structural constituent of cytoskeleton [GO:0005200] LLADKER 2.460000038 0 843.5184619 15.16715 14.45891 16.91012 14.62772 14.53173 A0A8C0MZ78 A0A8C0MZ78_CANLF Lamin B2 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882]; nuclear envelope [GO:0005635]; nuclear lamina [GO:0005652] QGHGHGHGR 3.420000076 0.180005674 942.2642045 15.22999 13.4854 14.96527 13.31696 14.46429 A0A8C0MDT6 A0A8C0MDT6_CANLF Laminin G domain-containing protein NRXN2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SAVLVR 7.5 0.130730044 644.4147603 14.54463 14.74069 14.43721 15.55426 16.59105 A0A8I3RRA4 A0A8I3RRA4_CANLF Laminin subunit alpha 2 LAMA2 Canis lupus familiaris (Dog) (Canis familiaris) "axon guidance [GO:0007411]; cell adhesion [GO:0007155]; positive regulation of synaptic transmission, cholinergic [GO:0032224]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]" basement membrane [GO:0005604]; neuromuscular junction [GO:0031594]; sarcolemma [GO:0042383]; synaptic cleft [GO:0043083] signaling receptor binding [GO:0005102] GGTPTHTR 4.590000153 0 826.4054554 17.55257 15.14604 15.894 16.34629 16.11437 A0A8P0PL88 A0A8P0PL88_CANLF Laminin subunit beta 2 LAMB2 Canis lupus familiaris (Dog) (Canis familiaris) EPQRGVGGR 2.24000001 0.286130726 954.1321622 15.19815 14.91713 15.53705 15.16166 13.26445 A0A8C0Q8S1 A0A8C0Q8S1_CANLF Laminin subunit gamma 3 Canis lupus familiaris (Dog) (Canis familiaris) basement membrane [GO:0005604]; extracellular region [GO:0005576] SQAGALDLK 2.720000029 0.383248653 901.1480272 16.46739 14.6298 0 15.77986 15.23972 A0A8C0PAT9 A0A8C0PAT9_CANLF Large ribosomal subunit protein bL21m Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; ribosome [GO:0005840] VLPTAAVR 2.319999933 0.099182565 825.5160763 0 15.34011 16.69448 14.14656 14.95761 Q9XSV0 Q9XSV0_CANLF Large ribosomal subunit protein eL6 (60S ribosomal protein L6) rpL6 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] intracellular membrane-bounded organelle [GO:0043231]; organelle membrane [GO:0031090]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] VXFLKQLSSGLLLVTGPLALNR 2.099999905 4.86E-13 2368.568774 11.93989 10.89015 9.927748 0 17.44705 A0A8P0PRH8 A0A8P0PRH8_CANLF "Large ribosomal subunit protein mL38 (39S ribosomal protein L38, mitochondrial)" MRPL38 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] VDIGLPPPK 2.960000038 0.141591686 935.9805011 15.41498 15.63615 16.64124 12.32392 15.90575 A0A8C0RSI3 A0A8C0RSI3_CANLF Large ribosomal subunit protein uL10 (60S acidic ribosomal protein P0) RPLP0 Canis lupus familiaris (Dog) (Canis familiaris) ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] MKSSSLGVR 1.779999971 0.34557942 964.952689 14.5355 17.44339 15.00481 15.53671 14.83671 A0A8C0LTV3 A0A8C0LTV3_CANLF Large ribosomal subunit protein uL15 (60S ribosomal protein L27a) LOC106559163 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] HWKHPR 3.960000038 0.224232543 861.8141065 16.6727 15.18512 11.77142 13.90219 16.22384 A0A8C0NYA7 A0A8C0NYA7_CANLF Large ribosomal subunit protein uL1m MRPL1 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] large ribosomal subunit [GO:0015934]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] HSLSKK 3.930000067 0.333727098 698.9667524 17.12671 0 14.65934 17.05623 16.02668 A0A8C0N6L0 A0A8C0N6L0_CANLF Large ribosomal subunit protein uL3 (60S ribosomal protein L3) Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] GLRTFK 7.510000229 0.117848722 720.2913613 17.47993 0 0 16.32059 18.70813 A0A8C0PBF1 A0A8C0PBF1_CANLF Large ribosomal subunit protein uL30 N-terminal eukaryotes domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EKPATSTR 1.940000057 0.363466022 890.2417225 14.89558 13.69633 16.06103 15.95133 16.67131 A0A8C0TIL8 A0A8C0TIL8_CANLF Lebercilin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EDLMIFR 20.28000069 0.323339329 923.5851593 16.53535 17.22011 14.10987 19.67303 15.43056 A2IBY8 MIP_CANLF Lens fiber major intrinsic protein (Aquaporin-0) MIP AQP0 Canis lupus familiaris (Dog) (Canis familiaris) gap junction-mediated intercellular transport [GO:1990349]; lens development in camera-type eye [GO:0002088]; positive regulation of cell adhesion [GO:0045785]; protein homotetramerization [GO:0051289]; response to stimulus [GO:0050896]; visual perception [GO:0007601]; water transport [GO:0006833] apical plasma membrane [GO:0016324]; endoplasmic reticulum [GO:0005783]; gap junction [GO:0005921]; plasma membrane [GO:0005886] calmodulin binding [GO:0005516]; structural constituent of eye lens [GO:0005212]; water channel activity [GO:0015250] SFAPAILTR 6.570000172 0.335816702 975.3700654 13.96629 15.40286 14.45916 13.44439 15.63136 A0A8C0NBC1 A0A8C0NBC1_CANLF Letm1 RBD domain-containing protein LETM2 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743] ribosome binding [GO:0043022] KPQVTSPQPSK 7.590000153 0 1197.507472 12.57362 6.543738 0 12.75256 14.9559 A0A8C0RW18 A0A8C0RW18_CANLF Leucine carboxyl methyltransferase 1 (EC 2.1.1.233) LCMT1 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259]; negative regulation of protein-containing complex assembly [GO:0031333]; regulation of apoptotic process [GO:0042981]; regulation of glucose metabolic process [GO:0010906]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266] cytosol [GO:0005829] protein C-terminal carboxyl O-methyltransferase activity [GO:0003880] GGNELGLK 4.510000229 0.411891483 787.9090749 15.59547 16.68336 16.42705 15.26045 15.58789 A0A8C0MYX2 A0A8C0MYX2_CANLF Leucine rich repeat and coiled-coil centrosomal protein 1 LRRCC1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] EVAKEER 8.909999847 0.289885591 857.4464745 14.28839 15.13906 17.00143 15.85979 15.55588 A0A8C0M7V8 A0A8C0M7V8_CANLF Leucine rich repeat containing 55 LRRC55 Canis lupus familiaris (Dog) (Canis familiaris) voltage-gated potassium channel complex [GO:0008076] potassium channel activator activity [GO:0099104]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249] NLSLAHNR 9.369999886 0.265243981 924.989571 20.95597 0 21.31837 15.9886 22.19307 A0A8C0MXU4 A0A8C0MXU4_CANLF Leucine rich repeat containing 58 Canis lupus familiaris (Dog) (Canis familiaris) LGGPGALPK 17.88999939 0 810.2470787 15.69795 14.5556 11.35829 15.01804 14.15706 A0A8C0M535 A0A8C0M535_CANLF Leucine rich repeat transmembrane neuronal 2 LRRTM2 Canis lupus familiaris (Dog) (Canis familiaris) long-term synaptic potentiation [GO:0060291]; negative regulation of receptor internalization [GO:0002091]; positive regulation of synapse assembly [GO:0051965]; synapse organization [GO:0050808] GABA-ergic synapse [GO:0098982]; postsynaptic specialization membrane [GO:0099634] ELILSSNK 28.73999977 0.317797635 903.1546427 16.06952 14.61928 14.7466 21.97474 15.0916 A0A8C0NL63 A0A8C0NL63_CANLF Leukocyte cell-derived chemotaxin 1 (Chondromodulin) CNMD Canis lupus familiaris (Dog) (Canis familiaris) cartilage development [GO:0051216]; cell differentiation [GO:0030154] endomembrane system [GO:0012505]; extracellular region [GO:0005576]; membrane [GO:0016020] AQVKAR 5.559999943 0.288921383 672.9342632 14.83263 18.05972 17.01336 16.04331 16.78167 A0A8C0MKX7 A0A8C0MKX7_CANLF Leukotriene C4 synthase (EC 4.4.1.20) (Glutathione S-transferase LTC4) (Leukotriene-C(4) synthase) LTC4S Canis lupus familiaris (Dog) (Canis familiaris) leukotriene biosynthetic process [GO:0019370] endoplasmic reticulum membrane [GO:0005789]; nuclear outer membrane [GO:0005640] enzyme activator activity [GO:0008047]; lyase activity [GO:0016829] THPGAPGRAPGGSR 12.67000008 0.053152666 1318.913142 15.97664 0 15.46969 17.93796 15.50472 A0A8C0MVZ1 A0A8C0MVZ1_CANLF Leydig cell tumor 10 kDa protein homolog C20H19orf53 Canis lupus familiaris (Dog) (Canis familiaris) KDLEVSIR 6.639999866 0.289925267 958.7146086 16.56063 14.40313 14.10189 14.97687 14.52204 A0A8I3Q1U2 A0A8I3Q1U2_CANLF Long-chain-fatty-acid--CoA ligase (EC 6.2.1.15) (EC 6.2.1.3) (Acyl-CoA synthetase) (Long-chain acyl-CoA synthetase) ACSL5 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; oleoyl-CoA ligase activity [GO:0090434] GSNVFK 2.819999933 0.381955531 651.9906513 15.83612 15.25361 13.68682 16.57509 14.87847 A0A8I3NMI6 A0A8I3NMI6_CANLF Lymphocyte antigen 6 family member G6D LY6G6D Canis lupus familiaris (Dog) (Canis familiaris) acetylcholine receptor signaling pathway [GO:0095500] external side of plasma membrane [GO:0009897]; protein-containing complex [GO:0032991]; synapse [GO:0045202] acetylcholine receptor inhibitor activity [GO:0030550]; identical protein binding [GO:0042802] KPQPGLGQSK 5.460000038 0.337530474 1039.854447 13.66537 14.1817 17.14138 14.50604 15.76201 A0A8C0Z4E3 A0A8C0Z4E3_CANLF Lysine demethylase 1B KDM1B Canis lupus familiaris (Dog) (Canis familiaris) epigenetic programing of female pronucleus [GO:0044726]; genomic imprinting [GO:0071514] nucleoplasm [GO:0005654]; nucleosome [GO:0000786] FAD binding [GO:0071949]; FAD-dependent H3K4me/H3K4me3 demethylase activity [GO:0140682]; histone binding [GO:0042393]; zinc ion binding [GO:0008270] DPTMYLALR 4.110000134 0.160693171 1080.160355 18.05475 15.06521 0 15.97208 17.67164 A0A8C0S9F2 A0A8C0S9F2_CANLF Lysine--tRNA ligase (EC 6.1.1.6) (Lysyl-tRNA synthetase) KARS1 Canis lupus familiaris (Dog) (Canis familiaris) basophil activation involved in immune response [GO:0002276]; diadenosine tetraphosphate biosynthetic process [GO:0015966]; ERK1 and ERK2 cascade [GO:0070371]; lysyl-tRNA aminoacylation [GO:0006430]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of inflammatory response to antigenic stimulus [GO:0002863]; positive regulation of macrophage activation [GO:0043032] aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytosol [GO:0005829]; extracellular space [GO:0005615]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP adenylyltransferase activity [GO:0003877]; ATP binding [GO:0005524]; lysine-tRNA ligase activity [GO:0004824]; nucleic acid binding [GO:0003676]; protein homodimerization activity [GO:0042803] LQVMANSR 5.539999962 2.46E-13 918.6144229 15.04579 14.81617 16.60786 14.94989 12.52525 A0A8C0MPG8 A0A8C0MPG8_CANLF Lysine-specific demethylase (EC 1.14.11.65) Canis lupus familiaris (Dog) (Canis familiaris) demethylation [GO:0070988] histone deacetylase complex [GO:0000118] histone H3K9 demethylase activity [GO:0032454]; metal ion binding [GO:0046872] AGVIR 9.840000153 0.240764219 516.6654935 16.1936 14.57754 16.82272 18.30618 15.1987 A0A8C0Z0Y1 A0A8C0Z0Y1_CANLF M-phase phosphoprotein 6 MPHOSPH6 Canis lupus familiaris (Dog) (Canis familiaris) QCACAGVR 7.690000057 0.018862387 921.1774979 12.63728 14.5074 11.82966 0 11.77696 A0A8C0RFC6 A0A8C0RFC6_CANLF MAGE domain-containing protein LOC111095049 Canis lupus familiaris (Dog) (Canis familiaris) AHEETSKLR 2.950000048 0.24038406 1071.704135 11.69861 10.1716 15.65171 15.84771 12.78316 A0A8I3NEN9 A0A8I3NEN9_CANLF MAGUK p55 scaffold protein 2 MPP2 Canis lupus familiaris (Dog) (Canis familiaris) excitatory postsynaptic potential [GO:0060079]; long-term synaptic potentiation [GO:0060291] bicellular tight junction [GO:0005923]; dendrite membrane [GO:0032590]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685] structural constituent of postsynaptic density [GO:0098919]; transmembrane transporter binding [GO:0044325] ELQAAMEKLR 2.299999952 0.133471201 1203.847069 12.17949 7.853189 14.79992 13.33622 12.28716 A0A8C0LVZ7 A0A8C0LVZ7_CANLF MAM domain containing glycosylphosphatidylinositol anchor 2 MDGA2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886]; side of membrane [GO:0098552] EMSGMYR 5.630000114 0.176765675 889.5562873 16.95025 14.42429 16.14403 14.88462 15.938 A0A8C0NLQ2 A0A8C0NLQ2_CANLF MANSC domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] IAHPLPK 6.010000229 0.247103773 776.5249559 12.2586 16.78136 14.65706 15.05672 14.90122 A0A8C0S8D9 A0A8C0S8D9_CANLF MAX dimerization protein MGA MGA Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893] MLL1 complex [GO:0071339] DNA-binding transcription factor activity [GO:0003700]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] HAHTIPGDK 1.389999986 0.26603284 974.8034064 13.91009 10.86863 0 12.18087 13.65959 A0A8C0P6E7 A0A8C0P6E7_CANLF MHD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] clathrin adaptor complex [GO:0030131] SEGLKYK 3.589999914 0.155170629 825.0788329 14.86158 13.01591 16.92776 14.73196 14.50583 A0A8C0P520 A0A8C0P520_CANLF MICOS complex subunit MIC13 MICOS13 Canis lupus familiaris (Dog) (Canis familiaris) MICOS complex [GO:0061617] AREYSR 9.050000191 0.320000915 780.0639564 17.88712 17.63235 16.46884 19.81881 16.91606 A0A8C0NXN8 A0A8C0NXN8_CANLF MOB kinase activator 2 MOB2 Canis lupus familiaris (Dog) (Canis familiaris) DWLMGKSK 3.980000019 0.365131073 964.3552992 15.85288 16.92189 16.26515 15.25855 16.20962 A0A8C0MBD1 A0A8C0MBD1_CANLF MOK protein kinase MOK Canis lupus familiaris (Dog) (Canis familiaris) ciliary base [GO:0097546]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] LTLSGVTK 13.72000027 0.292432387 818.4119785 13.40763 13.66104 17.9155 13.41401 16.46123 A0A8C0P154 A0A8C0P154_CANLF MOSC domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] catalytic activity [GO:0003824]; molybdenum ion binding [GO:0030151]; pyridoxal phosphate binding [GO:0030170] CLRPLPSGFR 3.450000048 0 1203.398967 12.5136 0 12.22455 15.1588 10.31412 A0A8C0NBM6 A0A8C0NBM6_CANLF MPN domain-containing protein PRPF8 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" spliceosomal complex [GO:0005681] metallopeptidase activity [GO:0008237]; U5 snRNA binding [GO:0030623]; U6 snRNA binding [GO:0017070] HTLAYDKGWR 4.340000153 0.003817216 1246.09682 12.81492 8.135712 12.15916 15.80943 10.40512 A0A8C0SBJ1 A0A8C0SBJ1_CANLF Maestro heat like repeat family member 6 Canis lupus familiaris (Dog) (Canis familiaris) SASAIPPAGR 12.78999996 0.166496312 926.5888445 19.08048 20.73479 0 21.49556 17.35029 J7JER2 J7JER2_9PAPI Major capsid protein L1 L1 Canis familiaris papillomavirus 13 endocytosis involved in viral entry into host cell [GO:0075509]; virion attachment to host cell [GO:0019062] host cell nucleus [GO:0042025]; T=7 icosahedral viral capsid [GO:0039620] structural molecule activity [GO:0005198] LMLPDPNK 14.43000031 0.092055655 927.6400211 20.16852 17.87008 18.31258 17.41381 17.74479 A0A0U4B8R4 A0A0U4B8R4_9PAPI Major capsid protein L1 L1 Canis familiaris papillomavirus 17 endocytosis involved in viral entry into host cell [GO:0075509]; virion attachment to host cell [GO:0019062] host cell nucleus [GO:0042025]; T=7 icosahedral viral capsid [GO:0039620] structural molecule activity [GO:0005198] HEETVIVPKVTGNQFR 4.320000172 0 1854.425151 0 14.66255 15.96736 0 0 A0A8C0YTE7 A0A8C0YTE7_CANLF Major facilitator superfamily (MFS) profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] SRAPGSR 5.909999847 0.275354542 729.0137374 19.47293 14.78491 15.64185 13.96594 15.49821 A0A8C0M4Z6 A0A8C0M4Z6_CANLF Malic enzyme ME2 Canis lupus familiaris (Dog) (Canis familiaris) "malic enzyme activity [GO:0004470]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" CLPVCIDVGTDNPALLK 2.099999905 0.559725325 1885.019016 0 17.71939 0 20.76771 17.48679 A0A8C0NCH8 A0A8C0NCH8_CANLF Matrin 3 MATR3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] RNA binding [GO:0003723]; zinc ion binding [GO:0008270] TESTTEGK 3.369999886 0.292572383 851.5607103 18.31144 14.82141 0 16.36957 16.52773 A0A8C0N978 A0A8C0N978_CANLF Matrin-type domain-containing protein CIZ1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] AHILVK 17.69000053 0.002193286 681.4392186 16.117 15.55378 15.34758 15.61915 15.22555 A0A8C0TF13 A0A8C0TF13_CANLF Matrix metallopeptidase 20 MMP20 Canis lupus familiaris (Dog) (Canis familiaris) amelogenesis [GO:0097186]; extracellular matrix disassembly [GO:0022617]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508] extracellular matrix [GO:0031012] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] ELLLFR 33.31999969 0.288116773 790.4396591 18.60741 18.2425 20.57459 18.44529 18.65037 A0A8C0P0M1 A0A8C0P0M1_CANLF Matrix metallopeptidase 26 MMP26 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular matrix [GO:0031012] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] SLNSIMYPR 9.260000229 0.118270822 1095.668964 15.81276 12.54864 16.90506 13.95973 13.7603 A0A8C0N4J5 A0A8C0N4J5_CANLF Mediator complex subunit Med12 domain-containing protein MED12L Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] mediator complex [GO:0016592] beta-catenin binding [GO:0008013]; transcription coregulator activity [GO:0003712] QLLPLPK 21.93000031 0.543550213 807.2294694 0 17.85307 17.748 16.2726 14.64359 A0A8C0P8K6 A0A8C0P8K6_CANLF Mediator of RNA polymerase II transcription subunit 26 (Cofactor required for Sp1 transcriptional activation subunit 7) (Mediator complex subunit 26) SMIM7 MED26 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] mediator complex [GO:0016592] AGFSPDSSK 2.049999952 0.183061941 894.9743252 15.62122 14.86458 14.57331 11.41779 13.11385 A0A8C0PWZ3 A0A8C0PWZ3_CANLF Mediator of RNA polymerase II transcription subunit 27 (Cofactor required for Sp1 transcriptional activation subunit 8) (Mediator complex subunit 27) MED27 Canis lupus familiaris (Dog) (Canis familiaris) mediator complex [GO:0016592] TFSWQV 6.909999847 0.380308938 767.9846983 15.8653 0 17.62073 0 15.04278 A0A8C0NGY1 A0A8C0NGY1_CANLF Meiosis regulator and mRNA stability factor 1 (Limkain-b1) Canis lupus familiaris (Dog) (Canis familiaris) meiotic cell cycle [GO:0051321]; oogenesis [GO:0048477]; regulation of gene expression [GO:0010468] peroxisome [GO:0005777] RNA binding [GO:0003723]; RNA nuclease activity [GO:0004540] SVTSSPVEK 12.47999954 0 934.3105215 12.66664 16.14789 11.85243 16.04395 10.03868 A0A8C0NJW7 A0A8C0NJW7_CANLF Meiosis-specific nuclear structural protein 1 Canis lupus familiaris (Dog) (Canis familiaris) meiotic cell cycle [GO:0051321] axoneme [GO:0005930]; motile cilium [GO:0031514]; nucleus [GO:0005634] NQFLADK 4.610000134 0.395110181 836.0179461 16.61043 14.44746 15.0879 12.75668 15.79386 A0A8C0MF03 A0A8C0MF03_CANLF Melanocortin receptor 5 RNMT Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] melanocortin receptor activity [GO:0004977] SFKEIILLSK 10.94999981 0.149397636 1177.251571 0 15.93379 0 16.99606 13.56958 A0A8C0RJY5 A0A8C0RJY5_CANLF Membrane protein BRI3 (Brain protein I3) BRI3 Canis lupus familiaris (Dog) (Canis familiaris) lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471] EGGGVRTR 5.119999886 0.339924191 832.3163231 13.90722 16.58393 15.36843 14.65256 13.99906 A0A8I3MI31 A0A8I3MI31_CANLF Mesoderm posterior bHLH transcription factor 1 MESP1 Canis lupus familiaris (Dog) (Canis familiaris) cardiac atrium formation [GO:0003210]; cardiac cell fate determination [GO:0060913]; cardiac vascular smooth muscle cell differentiation [GO:0060947]; cardiac ventricle formation [GO:0003211]; cardioblast anterior-lateral migration [GO:0003259]; cardioblast migration to the midline involved in heart field formation [GO:0060975]; endothelial cell differentiation [GO:0045446]; gastrulation [GO:0007369]; gene expression [GO:0010467]; growth involved in heart morphogenesis [GO:0003241]; heart induction [GO:0003129]; heart looping [GO:0001947]; lateral mesoderm development [GO:0048368]; mesodermal cell migration [GO:0008078]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endodermal cell fate specification [GO:0042664]; negative regulation of mesodermal cell fate specification [GO:0042662]; neurogenesis [GO:0022008]; positive regulation of hepatocyte differentiation [GO:0070368]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of striated muscle cell differentiation [GO:0051155]; secondary heart field specification [GO:0003139]; signal transduction involved in regulation of gene expression [GO:0023019]; sinoatrial node cell differentiation [GO:0060921]; sinus venosus morphogenesis [GO:0003236] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" QSASEREK 8.699999809 0.367715097 935.0217036 17.61705 17.4479 17.55843 18.87784 17.61843 A0A8C0THE2 A0A8C0THE2_CANLF Metadherin Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of apoptotic process [GO:0043066]; positive regulation of angiogenesis [GO:0045766]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123] membrane [GO:0016020]; nucleus [GO:0005634] QNSVPPSQSK 8.079999924 0.154099153 1070.556939 14.94317 11.89462 15.20937 17.37005 14.57116 A0A8C0NXC6 A0A8C0NXC6_CANLF Metal transporter CNNM1 Canis lupus familiaris (Dog) (Canis familiaris) magnesium ion homeostasis [GO:0010960] plasma membrane [GO:0005886] transmembrane transporter activity [GO:0022857] AAAATAVGVR 8.640000343 0.225574061 887.2350409 16.74373 14.94345 16.94733 14.78412 14.91008 A0A8I3MHD6 A0A8I3MHD6_CANLF Methylosome protein WDR77 (Methylosome protein 50) (WD repeat-containing protein 77) WDR77 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] PRLSTR 6.559999943 0.477710338 728.9264268 16.5927 17.07799 15.31474 15.63193 17.15656 A0A8C0T388 A0A8C0T388_CANLF Methyltransferase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GASRLPR 3.809999943 0.395122971 756.2205399 15.66888 15.17461 17.04912 16.57039 16.80161 A0A8C0NYF9 A0A8C0NYF9_CANLF Mevalonate kinase (MK) (EC 2.7.1.36) MVK Canis lupus familiaris (Dog) (Canis familiaris) "cholesterol biosynthetic process [GO:0006695]; isopentenyl diphosphate biosynthetic process, mevalonate pathway [GO:0019287]; negative regulation of inflammatory response [GO:0050728]; phosphorylation [GO:0016310]" cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; mevalonate kinase activity [GO:0004496] EVAGIPK 6.389999866 0.23896377 712.164998 14.24184 16.16702 14.09626 12.45298 14.03799 A0A8C0T980 A0A8C0T980_CANLF Microtubule actin crosslinking factor 1 MACF1 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament cytoskeleton organization [GO:0045104] cell projection [GO:0042995]; cytoplasm [GO:0005737]; membrane [GO:0016020]; microtubule [GO:0005874] actin binding [GO:0003779]; calcium ion binding [GO:0005509]; microtubule binding [GO:0008017] VDFLSTLK 11.43000031 0.19976876 923.6084812 12.84105 14.80798 14.4029 15.50704 15.83521 A0A8I3PGC1 A0A8I3PGC1_CANLF Microtubule associated scaffold protein 2 MTUS2 Canis lupus familiaris (Dog) (Canis familiaris) LVAQSGGR 3.960000038 0 788.3073946 14.58359 14.5589 15.32442 15.16243 14.89742 A0A8C0M8U8 A0A8C0M8U8_CANLF Microtubule associated tyrosine carboxypeptidase 2 MATCAP2 Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787] GLAVIENMR 27.68000031 0.314971539 1018.724155 16.69792 17.34241 17.37407 15.72621 17.75397 A0A8C0ML32 A0A8C0ML32_CANLF Microtubule-associated protein MAPT Canis lupus familiaris (Dog) (Canis familiaris) axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; microtubule [GO:0005874]; plasma membrane [GO:0005886] microtubule binding [GO:0008017] GADGKTGTK 2.910000086 0.289020737 833.8147628 16.21753 15.55886 14.02723 15.53153 16.4465 A0A8C0MGE4 A0A8C0MGE4_CANLF Mitochondrial chaperone BCS1 (BCS1-like protein) BCS1L Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial cytochrome c oxidase assembly [GO:0033617]; mitochondrial respiratory chain complex I assembly [GO:0032981]; mitochondrial respiratory chain complex III assembly [GO:0034551] mitochondrial inner membrane [GO:0005743] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] WYTDRGIPYR 3.200000048 0 1325.828171 0 14.42573 0 0 0 A0A8I3MU85 A0A8I3MU85_CANLF Mitochondrial import inner membrane translocase subunit TIM50 TIMM50 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial membrane organization [GO:0007006]; protein transport [GO:0015031]; release of cytochrome c from mitochondria [GO:0001836] nuclear speck [GO:0016607]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744] interleukin-2 receptor binding [GO:0005134]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; ribonucleoprotein complex binding [GO:0043021] VVVVDCKK 1.830000043 0.241910596 947.3334892 14.85049 15.13375 13.20101 16.43799 16.38916 A0A8C0MMF6 A0A8C0MMF6_CANLF Mitochondrial pyruvate carrier MPC1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial pyruvate transmembrane transport [GO:0006850] mitochondrial inner membrane [GO:0005743] KSPEIISGR 10.10999966 0.216200654 986.3370916 15.94709 14.52003 2.255987 11.15309 8.178979 A0A8C0MYE7 A0A8C0MYE7_CANLF Mitochondrial ribosomal protein S18A MRPS18A Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] mitochondrion [GO:0005739]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] WNLKHK 4.429999828 0.027376779 824.4026597 15.29139 18.82937 16.64591 15.74543 17.79731 A0A8P0NV68 A0A8P0NV68_CANLF Mitogen-activated protein kinase 15 (EC 2.7.11.24) MAPK15 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; MAP kinase activity [GO:0004707] EGGGALPGLADR 14.51000023 0.161233336 1111.723411 17.49473 14.30229 16.53406 14.94949 0 A0A8C0MAL0 A0A8C0MAL0_CANLF Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) MAP3K21 Canis lupus familiaris (Dog) (Canis familiaris) phosphorylation [GO:0016310] plasma membrane [GO:0005886] ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709] GGALNRALAAAAASPDPR 5.659999847 2.46E-13 1679.823821 13.60993 16.14939 17.10985 15.77472 15.37081 A0A8I3N1K2 A0A8I3N1K2_CANLF Mitotic spindle assembly checkpoint protein MAD2B (Mitotic arrest deficient 2-like protein 2) MAD2L2 Canis lupus familiaris (Dog) (Canis familiaris) "actin filament organization [GO:0007015]; DNA damage response, signal transduction resulting in transcription [GO:0042772]; double-strand break repair [GO:0006302]; error-prone translesion synthesis [GO:0042276]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; regulation of cell growth [GO:0001558]" anaphase-promoting complex [GO:0005680]; nucleoplasm [GO:0005654]; spindle [GO:0005819]; zeta DNA polymerase complex [GO:0016035] JUN kinase binding [GO:0008432]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] VVVVILDK 5.039999962 1.22E-13 883.4202147 13.88155 15.042 16.6396 11.96974 14.69789 A0A8C0SNL7 A0A8C0SNL7_CANLF Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member) SMAD7 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] metal ion binding [GO:0046872] AHGAGGGGAGR 4.21999979 1.23E-13 868.5966642 10.52958 9.875602 13.04198 0 0 Q6UR05 MRP1_CANLF Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter) ABCC1 MRP1 Canis lupus familiaris (Dog) (Canis familiaris) cyclic nucleotide transport [GO:0070729]; glutathione transmembrane transport [GO:0034775]; leukotriene transport [GO:0071716]; lipid transport [GO:0006869]; positive regulation of inflammatory response [GO:0050729]; response to xenobiotic stimulus [GO:0009410]; xenobiotic transport [GO:0042908] basolateral plasma membrane [GO:0016323] ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; glutathione transmembrane transporter activity [GO:0034634]; xenobiotic transmembrane transporter activity [GO:0042910] FYVASSRQLK 5.369999886 0.287398599 1197.885935 12.23406 16.60764 15.25864 0 13.09557 A0A8C0MYR6 A0A8C0MYR6_CANLF Multiple PDZ domain crumbs cell polarity complex component Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] VKIIFIR 24.06999969 0.092454957 887.8509784 17.19886 18.05667 14.91268 0 16.36118 A0A8C0NZB1 A0A8C0NZB1_CANLF "Multiple inositol polyphosphate phosphatase 1 (EC 3.1.3.62) (EC 3.1.3.80) (2,3-bisphosphoglycerate 3-phosphatase)" Canis lupus familiaris (Dog) (Canis familiaris) phosphatase activity [GO:0016791] INDKLMR 28.29999924 0.069560614 905.859301 24.04946 21.40322 23.07499 25.03988 0 A0A8C0TK05 A0A8C0TK05_CANLF Multiple inositol-polyphosphate phosphatase 1 Canis lupus familiaris (Dog) (Canis familiaris) RGAGGGAGSAGGR 3.950000048 0 1030.500821 0 0 0 15.355 15.7385 A0A8C0NBG1 A0A8C0NBG1_CANLF Multiple myeloma tumor-associated protein 2-like N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DPGAGAAR 8.390000343 0.377860098 712.7994336 18.12529 17.77935 17.027 20.02262 15.99453 A0A8C0LXA9 A0A8C0LXA9_CANLF Myb/SANT-like DNA-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) NWTDAEMR 8.819999695 0.110132282 1037.83305 13.62847 11.5444 16.02596 15.24615 12.90206 A0A8I3P7A7 A0A8I3P7A7_CANLF Myeloperoxidase MPO Canis lupus familiaris (Dog) (Canis familiaris) defense response to fungus [GO:0050832]; hydrogen peroxide catabolic process [GO:0042744]; hypochlorous acid biosynthetic process [GO:0002149]; low-density lipoprotein particle remodeling [GO:0034374]; removal of superoxide radicals [GO:0019430]; respiratory burst involved in defense response [GO:0002679]; response to yeast [GO:0001878] azurophil granule [GO:0042582]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleoplasm [GO:0005654] heme binding [GO:0020037]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601] LATELRR 15.69999981 0.373337935 857.9922295 16.25564 15.7901 16.17506 15.94304 14.60237 A0A8I3PZH0 A0A8I3PZH0_CANLF Myosin IXB MYO9B Canis lupus familiaris (Dog) (Canis familiaris) actin filament-based movement [GO:0030048]; regulation of Rho protein signal transduction [GO:0035023]; Rho protein signal transduction [GO:0007266]; Roundabout signaling pathway [GO:0035385] actin filament [GO:0005884]; cell cortex [GO:0005938]; cytosol [GO:0005829]; myosin complex [GO:0016459]; perinuclear region of cytoplasm [GO:0048471] actin binding [GO:0003779]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; microfilament motor activity [GO:0000146]; Roundabout binding [GO:0048495]; small GTPase binding [GO:0031267] MTCHKK 4.489999771 0.294017292 804.4596159 14.29554 15.30572 8.697286 13.3787 11.27592 A0A8C0PC35 A0A8C0PC35_CANLF Myosin XIX MYO19 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] DPVPPELNR 1.639999986 0.195620059 1037.108137 15.99476 14.01694 15.30868 14.27057 13.43958 A0A8I3MC52 A0A8I3MC52_CANLF Myosin heavy chain 10 MYH10 Canis lupus familiaris (Dog) (Canis familiaris) actin filament-based movement [GO:0030048]; actomyosin structure organization [GO:0031032]; mitotic cytokinesis [GO:0000281]; positive regulation of protein secretion [GO:0050714] cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; midbody [GO:0030496]; myosin II complex [GO:0016460]; myosin II filament [GO:0097513]; stress fiber [GO:0001725] actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146]; mRNA 5'-UTR binding [GO:0048027]; RNA stem-loop binding [GO:0035613] DVEALGQR 15.60999966 0.152999662 888.3571902 14.31469 15.45006 14.07519 14.03773 15.28573 A0A8I3NU84 A0A8I3NU84_CANLF Myosin heavy chain 7B MYH7B Canis lupus familiaris (Dog) (Canis familiaris) cardiac myofibril [GO:0097512]; myosin complex [GO:0016459] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] ENQSMLITGESGAGKTVNTK 6.139999866 0.566705517 2081.694515 11.52767 14.17821 18.39029 13.95931 14.066 A0A8I3PX90 A0A8I3PX90_CANLF "Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (Telokin)" MYLK Canis lupus familiaris (Dog) (Canis familiaris) aorta smooth muscle tissue morphogenesis [GO:0060414]; bleb assembly [GO:0032060]; cellular hypotonic response [GO:0071476]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cell migration [GO:0030335]; positive regulation of wound healing [GO:0090303] cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; lamellipodium [GO:0030027]; stress fiber [GO:0001725] actin binding [GO:0003779]; ATP binding [GO:0005524]; myosin light chain kinase activity [GO:0004687] DSTFPK 1.840000033 0.362586828 695.1130929 0 16.01185 17.62906 0 16.54967 Q076A6 MYH1_CANLF "Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain, skeletal muscle, adult 1)" MYH1 Canis lupus familiaris (Dog) (Canis familiaris) muscle contraction [GO:0006936] cytoplasm [GO:0005737]; myofibril [GO:0030016]; myosin filament [GO:0032982]; myosin II complex [GO:0016460] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146] VGNEFVTK 2.660000086 0.138170018 893.5095021 16.27147 14.22402 15.73673 14.57479 16.6231 A0A8C0PT46 A0A8C0PT46_CANLF Myosin-11 (Myosin heavy chain 11) MYH11 Canis lupus familiaris (Dog) (Canis familiaris) cardiac muscle cell development [GO:0055013]; elastic fiber assembly [GO:0048251] cytoplasm [GO:0005737]; myosin complex [GO:0016459] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774]; structural constituent of muscle [GO:0008307] DADFNGTK 7.539999962 1.23E-13 868.5068362 15.80913 0 14.42174 16.79688 14.06433 A0A8C0NB07 A0A8C0NB07_CANLF "Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform)" MYH7 Canis lupus familiaris (Dog) (Canis familiaris) myofibril [GO:0030016]; myosin complex [GO:0016459] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] KDNANANK 8.159999847 0.32884311 874.8217847 16.6151 14.96803 0 16.57732 15.69585 A0A8C0M9Y5 A0A8C0M9Y5_CANLF Myotubularin phosphatase domain-containing protein MTMR10 Canis lupus familiaris (Dog) (Canis familiaris) ICNAITK 10.60000038 0.049854548 818.3135942 13.62421 13.78539 14.11715 13.24302 12.27235 A0A8C0ME00 A0A8C0ME00_CANLF Myotubularin phosphatase domain-containing protein MTMR11 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] TLDSEVR 4.820000172 0.382334869 819.0406874 17.44162 16.85107 17.47943 13.74683 16.01837 A0A8C0TAZ7 A0A8C0TAZ7_CANLF Myotubularin phosphatase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LSEVNENFSLCPSYPR 7.610000134 0.321244408 1911.21127 14.74868 0 17.31944 0 0 A0A8C0NPP5 A0A8C0NPP5_CANLF Myotubularin-related protein 12 (Inactive phosphatidylinositol 3-phosphatase 12) MTMR12 LOC487974 Canis lupus familiaris (Dog) (Canis familiaris) sarcomere [GO:0030017]; sarcoplasmic reticulum [GO:0016529] WIPEAQILGGGRVATMSK 4.010000229 0 1929.80647 12.90867 13.00822 17.87963 0 15.09129 A0A8C0PV52 A0A8C0PV52_CANLF N-acetylglucosaminylphosphatidylinositol deacetylase (EC 3.5.1.89) PIGL Canis lupus familiaris (Dog) (Canis familiaris) preassembly of GPI anchor in ER membrane [GO:0016254] endoplasmic reticulum membrane [GO:0005789] INSLYFL 3.450000048 0.182428648 869.2582928 14.99441 15.05328 13.03878 14.25638 15.16713 A0A8C0SVA3 A0A8C0SVA3_CANLF N-alpha-acetyltransferase 60 (EC 2.3.1.259) (EC 2.3.1.48) (Histone acetyltransferase type B protein 4) (N-acetyltransferase 15) (N-alpha-acetyltransferase F) NAA60 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; chromosome segregation [GO:0007059] peptide alpha-N-acetyltransferase activity [GO:0004596] WAASIRPHPSAPCR 1.649999976 2.43E-13 1604.616104 15.24481 13.21401 12.1392 14.22488 13.79509 A0A8C0T955 A0A8C0T955_CANLF N-terminal amino-acid N(alpha)-acetyltransferase NatA (EC 2.3.1.255) NAA10 RENBP Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] NatA complex [GO:0031415] peptide alpha-N-acetyltransferase activity [GO:0004596] AMIENFNAK 1.269999981 0.0559046 1054.262534 14.96523 15.5691 15.91071 14.13155 15.99667 A0A8C0M1T8 A0A8C0M1T8_CANLF "NACHT, LRR and PYD domains-containing protein 3" NLRP3 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; microtubule organizing center [GO:0005815]; mitochondrion [GO:0005739]; nucleus [GO:0005634] KEYFFK 5.489999771 0.455894766 859.9344569 18.69666 17.09775 16.5973 17.80964 17.94328 A0A8C0SUT5 A0A8C0SUT5_CANLF "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (Complex I-ESSS) (NADH-ubiquinone oxidoreductase ESSS subunit)" NDUFB11 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743] MAAGLLGLGAR 1.190000057 0.358765399 1029.910597 16.67984 15.57633 15.09175 16.90098 15.87753 A0A6H0DU94 A0A6H0DU94_CANLF NADH-ubiquinone oxidoreductase chain 5 (EC 7.1.1.2) ND5 Canis lupus familiaris (Dog) (Canis familiaris) ATP synthesis coupled electron transport [GO:0042773] mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] NADH dehydrogenase (ubiquinone) activity [GO:0008137] SSTXISNQK 3.839999914 0.322210596 992.1517179 14.24955 16.3999 15.19937 15.27195 15.36318 A0A8C0MTP4 A0A8C0MTP4_CANLF NBAS subunit of NRZ tethering complex NBAS Canis lupus familiaris (Dog) (Canis familiaris) "protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" endoplasmic reticulum [GO:0005783] VVTRHVSR 10.94999981 0.198606941 952.9831234 14.09599 11.67065 14.57572 16.42384 13.31334 A0A8C0PBN4 A0A8C0PBN4_CANLF NHS actin remodeling regulator Canis lupus familiaris (Dog) (Canis familiaris) HQLGMSR 4.210000038 0.390311708 828.9304397 16.72909 16.11915 0 17.81198 17.02927 A0A8C0RNY9 A0A8C0RNY9_CANLF NOP58 ribonucleoprotein NOP58 Canis lupus familiaris (Dog) (Canis familiaris) ribosome biogenesis [GO:0042254] box C/D RNP complex [GO:0031428]; nucleolus [GO:0005730]; small-subunit processome [GO:0032040] snoRNA binding [GO:0030515] VLNEKK 6.050000191 0.163533516 731.0147519 13.11093 15.16706 16.1102 15.51294 14.98822 A0A8C0P6P3 A0A8C0P6P3_CANLF "Nascent polypeptide-associated complex subunit alpha, muscle-specific form-like" Canis lupus familiaris (Dog) (Canis familiaris) MPPSPATPK 8.220000267 0.192594996 941.6938996 14.39795 16.10075 14.24804 14.97646 14.54903 A0A8C0RB12 A0A8C0RB12_CANLF Natural cytotoxicity triggering receptor 1 (Natural killer cell p46-related protein) NCR1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] MTLLTAGQYR 6.690000057 0 1169.874194 14.52109 14.41897 0 15.17765 13.96717 A0A8C0M5N9 A0A8C0M5N9_CANLF Nectin cell adhesion molecule 1 NECTIN1 Canis lupus familiaris (Dog) (Canis familiaris) desmosome organization [GO:0002934]; enamel mineralization [GO:0070166]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; iron ion transport [GO:0006826]; lens morphogenesis in camera-type eye [GO:0002089]; protein localization to cell junction [GO:1902414]; retina development in camera-type eye [GO:0060041] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; cell-cell contact zone [GO:0044291]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; presynaptic active zone membrane [GO:0048787] cell adhesion molecule binding [GO:0050839]; protein homodimerization activity [GO:0042803]; signaling receptor activity [GO:0038023] ARMGLAGAAGR 18.29999924 0.147241005 1030.848905 11.74473 0 16.60982 9.051535 14.4528 A0A8C0SZG9 A0A8C0SZG9_CANLF Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Enkephalinase) (Neutral endopeptidase 24.11) (Skin fibroblast elastase) MME Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metalloendopeptidase activity [GO:0004222] VNMWLRI 3.289999962 0.121163609 931.4569101 14.4187 12.73279 15.52851 14.60695 15.78369 A0A8P0PCF6 A0A8P0PCF6_CANLF Neurexin 3 Canis lupus familiaris (Dog) (Canis familiaris) TIFLVYR 8.380000114 0.184565432 911.8668494 13.98357 11.52443 14.28701 14.83959 14.67058 A0A8C0N9N3 A0A8C0N9N3_CANLF Neurobeachin Canis lupus familiaris (Dog) (Canis familiaris) ILNILTNK 27.06999969 0.06169365 927.6201906 16.69282 17.06223 17.76316 17.5405 20.6302 A0A8C0MZN5 A0A8C0MZN5_CANLF Neurofascin NFASC Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] NLILAPGEDGR 5.300000191 0.074316453 1153.969708 17.25242 16.65073 20.08314 16.74821 13.67292 A0A8C0TCE8 A0A8C0TCE8_CANLF Neurofilament light polypeptide (Neurofilament triplet L protein) NEFL Canis lupus familiaris (Dog) (Canis familiaris) axon [GO:0030424]; cytoplasm [GO:0005737]; intermediate filament [GO:0005882] YLLGDG 5.789999962 0.173094056 636.3932519 15.2754 18.63133 16.60611 0 18.86791 A0A8I3NM86 A0A8I3NM86_CANLF Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) LOC119880636 Canis lupus familiaris (Dog) (Canis familiaris) astrocyte differentiation [GO:0048708]; axon choice point recognition [GO:0016198]; cell fate commitment [GO:0045165]; radial glial cell differentiation [GO:0060019]; regulation of filopodium assembly [GO:0051489]; regulation of growth [GO:0040008] cytoplasm [GO:0005737]; dendrite [GO:0030425]; filopodium membrane [GO:0031527]; growth cone membrane [GO:0032584]; perikaryon [GO:0043204]; postsynaptic density [GO:0014069] calmodulin binding [GO:0005516] KSDGSM 8.590000153 0.34970826 624.2436389 14.94385 14.92411 16.80935 16.18942 15.82963 A0A8C0RAG9 A0A8C0RAG9_CANLF Nipped-B protein NIPBL Canis lupus familiaris (Dog) (Canis familiaris) brain development [GO:0007420]; cellular response to X-ray [GO:0071481]; chromatin remodeling [GO:0006338]; cognition [GO:0050890]; developmental growth [GO:0048589]; DNA damage response [GO:0006974]; ear morphogenesis [GO:0042471]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic forelimb morphogenesis [GO:0035115]; embryonic viscerocranium morphogenesis [GO:0048703]; external genitalia morphogenesis [GO:0035261]; eye morphogenesis [GO:0048592]; face morphogenesis [GO:0060325]; fat cell differentiation [GO:0045444]; gallbladder development [GO:0061010]; maintenance of mitotic sister chromatid cohesion [GO:0034088]; mitotic cohesin loading [GO:0061780]; mitotic sister chromatid segregation [GO:0000070]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract morphogenesis [GO:0003151]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of neuron migration [GO:2001224]; positive regulation of ossification [GO:0045778]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of embryonic development [GO:0045995]; regulation of hair cycle [GO:0042634]; sensory perception of sound [GO:0007605]; somatic stem cell population maintenance [GO:0035019]; uterus morphogenesis [GO:0061038] chromatin [GO:0000785]; cytosol [GO:0005829]; integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; Scc2-Scc4 cohesin loading complex [GO:0090694] chromo shadow domain binding [GO:0070087]; cohesin loader activity [GO:0061775]; histone deacetylase binding [GO:0042826]; mediator complex binding [GO:0036033]; promoter-specific chromatin binding [GO:1990841]; transcription corepressor activity [GO:0003714] SSGGGR 3.609999895 0.034339508 520.3296563 15.95938 16.31526 14.13578 15.74788 16.51021 A0A8C0TV82 A0A8C0TV82_CANLF Nitric oxide synthase trafficking NOSTRIN Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897]; negative regulation of DNA-templated transcription [GO:0045892]; signal transduction [GO:0007165] nucleus [GO:0005634]; plasma membrane [GO:0005886] DNA binding [GO:0003677] FSKVLQSTQK 5.389999866 0.278542359 1167.262678 16.1009 15.47206 15.4039 15.6405 16.14617 A0A8I3MCI5 A0A8I3MCI5_CANLF NmrA-like family domain-containing protein 1 NMRAL1 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471] identical protein binding [GO:0042802] DLANMFR 6.019999981 0.299016128 865.2366802 16.79049 16.17322 15.27689 15.73726 0 A0A8C0NJV4 A0A8C0NJV4_CANLF Solute carrier family 18 member A3 SLC18A3 Canis lupus familiaris (Dog) (Canis familiaris) acetylcholine uptake [GO:0051630]; serotonin uptake [GO:0051610] synaptic vesicle membrane [GO:0030672] acetylcholine:proton antiporter activity [GO:0005278]; monoamine:proton antiporter activity [GO:0015311] AAAVK 2.470000029 0.045105234 459.2428093 18.08288 15.86916 16.55079 16.77318 16.99097 A0A8C0PUA5 A0A8C0PUA5_CANLF "FYVE, RhoGEF and PH domain containing 3" FGD3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872] ADPGK 6.449999809 0.313699331 487.0238667 15.15069 16.66709 13.67595 14.65553 15.61054 A0A8C0N0T3 A0A8C0N0T3_CANLF C2H2-type domain-containing protein LOC484540 Canis lupus familiaris (Dog) (Canis familiaris) AFTYR 3.019999981 0.383277994 656.8128205 15.58354 18.19209 18.58748 17.77516 0 A0A8C0NQU9 A0A8C0NQU9_CANLF USP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cysteine-type deubiquitinase activity [GO:0004843] AGGDK 4.090000153 0.239417361 446.7221098 13.05867 13.65143 17.31936 15.70356 16.09083 A0A8C0MVV6 A0A8C0MVV6_CANLF Mitochondrial S-adenosylmethionine carrier protein (Solute carrier family 25 member 26) SLC25A26 Canis lupus familiaris (Dog) (Canis familiaris) transmembrane transport [GO:0055085] membrane [GO:0016020] AGGFR 3.960000038 0.375680777 507.5750282 17.04402 14.63814 16.82727 17.90466 18.57063 A0A8I3NTR5 A0A8I3NTR5_CANLF R3H-associated N-terminal domain-containing protein R3HDM4 Canis lupus familiaris (Dog) (Canis familiaris) AGIMR 6.96999979 0.043454568 564.2817975 19.57498 18.60575 20.68012 19.81485 19.04005 A0A0U5J457 A0A0U5J457_CANLF Tumor necrosis factor ligand superfamily member TNLG6A TNFSF10 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of release of cytochrome c from mitochondria [GO:0090200] extracellular space [GO:0005615]; membrane [GO:0016020] cytokine activity [GO:0005125]; identical protein binding [GO:0042802]; TRAIL binding [GO:0045569]; tumor necrosis factor receptor binding [GO:0005164]; zinc ion binding [GO:0008270] ALGHK 4.010000229 0.026932135 525.2663337 16.58918 15.3228 16.70103 16.98123 0 A0A8C0RGM4 A0A8C0RGM4_CANLF Family with sequence similarity 183 member A Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] ANDCR 2.880000114 0.282379788 636.0173742 11.33328 14.43593 14.99349 14.69564 15.85915 A0A8I3NKR9 A0A8I3NKR9_CANLF Centrosomal protein 131 CEP131 Canis lupus familiaris (Dog) (Canis familiaris) intraciliary transport involved in cilium assembly [GO:0035735]; intramanchette transport [GO:1990953]; manchette assembly [GO:1905198]; non-motile cilium assembly [GO:1905515]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of intracellular protein transport [GO:0090316]; protein localization to centrosome [GO:0071539]; regulation of centrosome duplication [GO:0010824]; sperm axoneme assembly [GO:0007288] acrosomal vesicle [GO:0001669]; centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; manchette [GO:0002177]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; sperm head-tail coupling apparatus [GO:0120212] protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877] APPPK 5.96999979 0.220827085 507.8555524 13.03565 17.30188 17.51367 17.13768 16.07646 A0A8I3S4R3 A0A8I3S4R3_CANLF Intraflagellar transport protein 57 homolog IFT57 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; heart looping [GO:0001947]; keratinocyte proliferation [GO:0043616]; motile cilium assembly [GO:0044458]; negative regulation of keratinocyte proliferation [GO:0010839]; neural tube closure [GO:0001843]; non-motile cilium assembly [GO:1905515]; regulation of apoptotic process [GO:0042981]; smoothened signaling pathway [GO:0007224] axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; dendrite terminus [GO:0044292]; Golgi apparatus [GO:0005794]; intraciliary transport particle B [GO:0030992]; photoreceptor connecting cilium [GO:0032391] AQTYR 1.919999957 0.385579846 637.8591194 13.97017 15.40077 14.28802 15.16923 15.15994 A0A8C0MSM3 A0A8C0MSM3_CANLF Aquaporin-1 (Aquaporin-CHIP) (Water channel protein for red blood cells and kidney proximal tubule) AQP1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] channel activity [GO:0015267] ARLDR 2.650000095 0.195915226 630.5489626 15.4892 17.24496 16.69037 15.62663 15.65653 A0A3G9E9X4 A0A3G9E9X4_LEIME Cytochrome b cyt b Leishmania mexicana respiratory electron transport chain [GO:0022904] mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] electron transfer activity [GO:0009055]; metal ion binding [GO:0046872] AVPDK 6.130000114 0.304207945 528.8159557 19.5457 15.44683 14.66613 15.58768 14.6291 A0A8C0NF92 A0A8C0NF92_CANLF Trafficking protein particle complex subunit 11 TRAPPC11 Canis lupus familiaris (Dog) (Canis familiaris) constitutive secretory pathway [GO:0045054]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; regulation of protein complex stability [GO:0061635] Golgi apparatus [GO:0005794]; TRAPP complex [GO:0030008] CPRMK 5.769999981 0.301648921 707.1521855 16.90179 18.23473 13.54613 16.70134 16.33716 A0A8C0T7L7 A0A8C0T7L7_CANLF Homeobox C11 HOXC11 Canis lupus familiaris (Dog) (Canis familiaris) anterior/posterior pattern specification [GO:0009952]; embryonic digit morphogenesis [GO:0042733]; embryonic skeletal joint morphogenesis [GO:0060272]; metanephros development [GO:0001656]; organ induction [GO:0001759]; proximal/distal pattern formation [GO:0009954] cytosol [GO:0005829]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CPYSK 14.47000027 0.457265549 654.8370769 19.36593 15.61869 16.36025 16.02081 19.08712 A0A8I3PUX1 A0A8I3PUX1_CANLF Holliday junction recognition protein HJURP Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] CVSVG 3.839999914 0.064632813 520.2992105 13.80144 13.49597 13.97841 13.69533 0 A0A024AGI8 A0A024AGI8_LIV Genome polyprotein Louping ill virus (Li) disruption by virus of host JAK-STAT cascade via inhibition of STAT2 activity [GO:0039564]; fusion of virus membrane with host endosome membrane [GO:0039654]; proteolysis [GO:0006508]; suppression by virus of host type I interferon-mediated signaling pathway [GO:0039502]; viral entry into host cell [GO:0046718]; viral RNA genome replication [GO:0039694]; virion attachment to host cell [GO:0019062] extracellular region [GO:0005576]; host cell endoplasmic reticulum membrane [GO:0044167]; host cell nucleus [GO:0042025]; membrane [GO:0016020]; viral capsid [GO:0019028]; virion membrane [GO:0055036] ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; mRNA (nucleoside-2'-O-)-methyltransferase activity [GO:0004483]; mRNA 5'-cap (guanine-N7-)-methyltransferase activity [GO:0004482]; protein dimerization activity [GO:0046983]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; RNA helicase activity [GO:0003724]; RNA-dependent RNA polymerase activity [GO:0003968]; serine-type endopeptidase activity [GO:0004252]; structural molecule activity [GO:0005198] DGVYR 5.409999847 0.392489252 609.9353133 15.58562 13.23814 15.90441 14.01339 15.83105 A0A8C0M1N2 A0A8C0M1N2_CANLF PH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DHAQK 5.519999981 0 597.3215882 13.82272 14.01822 13.15501 13.26026 9.799178 A0A8C0T3G0 A0A8C0T3G0_CANLF C-C motif chemokine receptor like 2 CCRL2 Canis lupus familiaris (Dog) (Canis familiaris) chemotaxis [GO:0006935] plasma membrane [GO:0005886] CCR chemokine receptor binding [GO:0048020]; chemokine receptor activity [GO:0004950] DHSTK 4.53000021 0.235851533 588.3290573 16.64042 15.43408 16.46663 16.47915 16.51591 A0A8C0PHV0 A0A8C0PHV0_CANLF AF4/FMR2 C-terminal homology domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] nucleus [GO:0005634] DIAIK 2.670000076 1.22E-13 558.4173233 15.73748 13.59577 12.98314 13.86245 13.13679 A0A8I3NXM9 A0A8I3NXM9_CANLF Pericentriolar material 1 PCM1 Canis lupus familiaris (Dog) (Canis familiaris) centrosome cycle [GO:0007098]; cytoplasmic microtubule organization [GO:0031122]; interkinetic nuclear migration [GO:0022027]; intraciliary transport involved in cilium assembly [GO:0035735]; microtubule anchoring at centrosome [GO:0034454]; negative regulation of neurogenesis [GO:0050768]; neuron migration [GO:0001764]; neuronal stem cell population maintenance [GO:0097150]; non-motile cilium assembly [GO:1905515]; positive regulation of intracellular protein transport [GO:0090316]; protein localization to centrosome [GO:0071539]; protein-containing complex localization to centriolar satellite [GO:0140706]; regulation of protein complex stability [GO:0061635]; social behavior [GO:0035176] apical part of cell [GO:0045177]; centriolar satellite [GO:0034451]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; pericentriolar material [GO:0000242]; protein-containing complex [GO:0032991] molecular adaptor activity [GO:0060090] DKTPK 5.309999943 0.041242804 588.3358696 16.451 15.44401 18.5468 16.19106 0 A0A8I3MJD9 A0A8I3MJD9_CANLF Metallothionein LOC100686073 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] DLGTG 2.529999971 0.344510614 462.4804603 15.83847 17.49842 20.49114 14.54316 17.73805 A0A8C0NCL6 A0A8C0NCL6_CANLF Elongator complex protein 1 ELP1 Canis lupus familiaris (Dog) (Canis familiaris) tRNA wobble uridine modification [GO:0002098] cytoplasm [GO:0005737]; elongator holoenzyme complex [GO:0033588]; nucleus [GO:0005634] DPDGK 3 0.287396845 531.132989 15.02302 16.74648 16.14307 15.37268 16.15703 P39881 CUX1_CANLF Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Clox-1) (Homeobox protein Clox) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] CUX1 CLOX CUTL1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" DPHHR 8.359999657 0.329600696 662.0749202 18.52043 20.15403 18.10221 23.35678 18.37072 A0A8C0NKQ9 A0A8C0NKQ9_CANLF "WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2" WFIKKN2 Canis lupus familiaris (Dog) (Canis familiaris) muscle cell development [GO:0055001]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; roof of mouth development [GO:0060021]; skeletal system development [GO:0001501]; transforming growth factor beta receptor signaling pathway [GO:0007179] extracellular space [GO:0005615] metalloendopeptidase inhibitor activity [GO:0008191]; receptor antagonist activity [GO:0048019]; serine-type endopeptidase inhibitor activity [GO:0004867]; transforming growth factor beta binding [GO:0050431] DRCEK 6.949999809 0.336784584 708.860042 15.91675 14.8883 15.58472 16.73111 15.88088 A0A8C0NCR3 A0A8C0NCR3_CANLF RAD51 interacting motif domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DYDIK 7.340000153 0.254581627 654.0884119 15.14959 15.58527 14.03335 15.76159 14.47879 A0A8C0PL14 A0A8C0PL14_CANLF BRCA2 and CDKN1A-interacting protein LOC100688306 Canis lupus familiaris (Dog) (Canis familiaris) cell cycle [GO:0007049]; DNA repair [GO:0006281] nucleus [GO:0005634]; spindle pole [GO:0000922] EHLSV 2.299999952 0.35238194 584.7552235 15.62573 15.67626 15.58846 16.91446 16.77739 A0A8C0MH94 A0A8C0MH94_CANLF Spermatogenesis-defective protein 39 homolog (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction) VIPAS39 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] early endosome [GO:0005769]; protein-containing complex [GO:0032991] EILFR 14.02999973 0.292711287 678.1151208 16.35994 21.69523 16.17814 17.77894 16.38109 A0A8C0NIC8 A0A8C0NIC8_CANLF Cadherin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] EPPAP 1.690000057 0.194834067 510.5252585 12.65228 12.03354 11.09517 13.54106 11.45764 A0A8C0M1I4 A0A8C0M1I4_CANLF Ig-like domain-containing protein MCAM Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] FGGVR 2.609999895 0.291497074 536.0531951 18.33117 19.17214 14.52446 16.45485 15.32377 A0A8I3PGU0 A0A8I3PGU0_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) FQGCI 8.520000458 0.193065368 622.9670256 13.48353 12.16353 13.36501 14.53265 13.64854 A0A8I3MXH9 A0A8I3MXH9_CANLF Tetratricopeptide repeat domain 9C TTC9C Canis lupus familiaris (Dog) (Canis familiaris) FRDCN 7.75 0.092327985 712.4034318 15.30027 15.07266 15.09544 15.27122 15.41821 A0A8C0LXK0 A0A8C0LXK0_CANLF KRAB domain-containing protein LOC100855887 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] FWMVK 6.050000191 0.030210167 709.5764618 14.74635 16.0349 18.77766 0 16.152 A0A8C0PK44 A0A8C0PK44_CANLF Semaphorin 4D SEMA4D Canis lupus familiaris (Dog) (Canis familiaris) axonogenesis [GO:0007409]; bone trabecula morphogenesis [GO:0061430]; leukocyte aggregation [GO:0070486]; negative regulation of cell adhesion [GO:0007162]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ossification involved in bone maturation [GO:0043931]; positive regulation of cell migration [GO:0030335]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of inhibitory synapse assembly [GO:1905704]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of cell shape [GO:0008360]; regulation of dendrite morphogenesis [GO:0048814]; semaphorin-plexin signaling pathway [GO:0071526] extracellular space [GO:0005615]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116] receptor ligand activity [GO:0048018]; semaphorin receptor binding [GO:0030215]; transmembrane signaling receptor activity [GO:0004888] GALHK 2.109999895 0.451481012 523.6642039 17.4835 16.43525 17.29889 15.92724 17.27902 A0A8C0NEZ4 A0A8C0NEZ4_CANLF Macrophage stimulating 1 MST1 Canis lupus familiaris (Dog) (Canis familiaris) embryo implantation [GO:0007566]; mammary duct terminal end bud growth [GO:0060763]; negative regulation of epithelial cell apoptotic process [GO:1904036]; positive regulation of gene expression [GO:0010628]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; proteolysis [GO:0006508]; regulation of macrophage chemotaxis [GO:0010758]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425] vacuole [GO:0005773] receptor tyrosine kinase binding [GO:0030971]; serine-type endopeptidase activity [GO:0004252] GEGYR 6.679999828 0.248114705 580.1474849 14.40331 17.68049 15.15712 0 13.51984 A0A8P0NGL6 A0A8P0NGL6_CANLF BHLH domain-containing protein MLX Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] protein dimerization activity [GO:0046983] GGAPK 4.610000134 0.059882902 429.2506904 15.12389 16.88985 18.76209 15.96619 15.23699 A0A8C0SA99 A0A8C0SA99_CANLF Interleukin 3 receptor subunit alpha IL3RA Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] cytokine receptor activity [GO:0004896] GGGVR 5.710000038 0.155542876 444.2194585 0 17.1755 15.0395 18.50317 18.35448 A0A8C0RJC9 A0A8C0RJC9_CANLF Junctophilin JPH1 Canis lupus familiaris (Dog) (Canis familiaris) muscle organ development [GO:0007517] junctional membrane complex [GO:0030314]; junctional sarcoplasmic reticulum membrane [GO:0014701]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; Z disc [GO:0030018] structural constituent of muscle [GO:0008307] GGLFR 15.96000004 0.421833623 549.0910274 16.71745 18.50829 16.62625 19.25317 16.95711 A0A8C0P8X1 A0A8C0P8X1_CANLF Ran-GTPase activating protein 1 C-terminal domain-containing protein CHADL Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] GTPase activator activity [GO:0005096] GGLPK 12.14000034 0 471.2307845 11.94197 12.64237 11.22716 11.94156 7.254835 A0A8C0RZW8 A0A8C0RZW8_CANLF Thymopoietin TMPO Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; nuclear envelope [GO:0005635] DNA binding [GO:0003677] GGVGR 3.779999971 0.049876141 444.2807722 16.03769 15.18959 15.6296 16.36194 17.17496 A0A8C0MH39 A0A8C0MH39_CANLF RNA binding protein fox-1 homolog RBFOX2 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA processing [GO:0006397]; nervous system development [GO:0007399]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" cytoplasm [GO:0005737]; nucleus [GO:0005634] RNA binding [GO:0003723] GGYSR 5.809999943 0.286154932 538.8678896 0 15.22579 14.0774 15.97451 16.06532 A0A8I3S6E7 A0A8I3S6E7_CANLF Autophagy and beclin 1 regulator 1 AMBRA1 Canis lupus familiaris (Dog) (Canis familiaris) autophagosome assembly [GO:0000045]; mitophagy [GO:0000423]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron apoptotic process [GO:0043524]; neural tube development [GO:0021915]; positive regulation of free ubiquitin chain polymerization [GO:1904544]; positive regulation of mitophagy [GO:1901526]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of regulatory T cell differentiation [GO:0045591]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of transcription by RNA polymerase II [GO:0006357]; response to mitochondrial depolarisation [GO:0098780] axoneme [GO:0005930]; Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335] GTPase binding [GO:0051020]; protein phosphatase binding [GO:0019903]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin protein ligase binding [GO:0031625] GHLNR 10.14000034 1.23E-13 597.2182177 15.23099 14.39836 14.14919 0 15.33359 A0A8C0NI15 A0A8C0NI15_CANLF Ribitol-5-phosphate transferase FKTN Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cell population proliferation [GO:0008285]; negative regulation of JNK cascade [GO:0046329]; protein O-linked mannosylation [GO:0035269] cis-Golgi network [GO:0005801]; endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; nucleus [GO:0005634] "phosphotransferase activity, for other substituted phosphate groups [GO:0016780]" GHMDR 3.74000001 0 630.4132762 14.86147 14.78399 13.70025 15.50331 14.22202 A0A8C0P1E8 A0A8C0P1E8_CANLF K Homology domain-containing protein PCBP1 LOC491817 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944]; viral RNA genome replication [GO:0039694] cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; postsynaptic density [GO:0014069] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; mRNA binding [GO:0003729]; sequence-specific single stranded DNA binding [GO:0098847]" GMGCS 2.779999971 0.210366971 509.9802321 15.21684 15.14104 16.39725 13.98461 15.46699 A0A8C0P7Y9 A0A8C0P7Y9_CANLF Phosphoinositide phospholipase C (EC 3.1.4.11) PLCD4 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042] endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0004435] GMLMR 19.84000015 0.188910307 623.238032 16.05114 17.84831 17.17299 16.3541 16.40767 A0A8C0QRU8 A0A8C0QRU8_CANLF APC regulator of WNT signaling pathway APC Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; DNA damage response [GO:0006974]; insulin receptor signaling pathway [GO:0008286]; mitotic cytokinesis [GO:0000281]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell migration [GO:0030335]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein localization to centrosome [GO:1904781]; positive regulation of pseudopodium assembly [GO:0031274]; protein-containing complex assembly [GO:0065003]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of microtubule-based movement [GO:0060632]; Wnt signaling pathway [GO:0016055] adherens junction [GO:0005912]; beta-catenin destruction complex [GO:0030877]; bicellular tight junction [GO:0005923]; catenin complex [GO:0016342]; centrosome [GO:0005813]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776]; lamellipodium [GO:0030027]; lateral plasma membrane [GO:0016328]; microtubule [GO:0005874]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ruffle membrane [GO:0032587] beta-catenin binding [GO:0008013]; dynein complex binding [GO:0070840]; gamma-catenin binding [GO:0045295]; microtubule plus-end binding [GO:0051010]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; ubiquitin protein ligase binding [GO:0031625] GPPLK 6.480000019 0.283591531 510.1493369 18.66676 17.27437 17.32217 16.79338 0 A0A8C0MCI8 A0A8C0MCI8_CANLF AMOP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GRSFR 5.96999979 0.029676511 621.3843663 15.39954 16.27006 17.21057 16.56188 16.09783 A0A8C0T111 A0A8C0T111_CANLF 3CxxC-type domain-containing protein RTP2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GSALL 2.630000114 0.001518671 459.3220954 15.83398 16.11027 15.20501 16.36903 16.13427 A0A8C0NEU9 A0A8C0NEU9_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) CSNK1E TMEM184B Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] GSATR 1.960000038 0.010652582 490.2317331 12.78191 13.75424 14.37649 15.53767 12.78425 A0A8C0MM54 A0A8C0MM54_CANLF Maternal embryonic leucine zipper kinase (EC 2.7.11.1) MELK Canis lupus familiaris (Dog) (Canis familiaris) intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; neural precursor cell proliferation [GO:0061351]; phosphorylation [GO:0016310]; positive regulation of apoptotic process [GO:0043065] cell cortex [GO:0005938]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein serine/threonine kinase activity [GO:0004674] GYTLK 3.400000095 0.314162082 582.2121024 16.25174 15.87519 16.51922 17.1943 15.60727 A0A8P0PNT3 A0A8P0PNT3_CANLF Uncharacterized protein FANCF Canis lupus familiaris (Dog) (Canis familiaris) interstrand cross-link repair [GO:0036297] Fanconi anaemia nuclear complex [GO:0043240] HALLL 30.44000053 0.085865309 566.3897794 20.32469 19.10468 19.04719 19.09288 18.85493 A0A8C0NE32 A0A8C0NE32_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) IHSGT 3 0.260926324 514.9655563 16.85339 16.06294 15.27654 0 16.83424 A0A8C0MAC7 A0A8C0MAC7_CANLF AAA+ ATPase domain-containing protein DNAH3 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] IINPK 6.409999847 0 583.3179891 16.94923 15.96655 15.66286 16.5121 14.71179 A0A8C0NZD7 A0A8C0NZD7_CANLF Calcium/calmodulin-dependent protein kinase type II subunit delta (EC 2.7.11.17) CAMK2D Canis lupus familiaris (Dog) (Canis familiaris) sarcolemma [GO:0042383]; sarcoplasmic reticulum membrane [GO:0033017] ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683] IINTK 15.35999966 0.437635484 588.7525328 0 16.78081 15.19509 16.14302 15.53179 A0A8C0PZD1 A0A8C0PZD1_CANLF Testis specific serine kinase 4 TSSK4 Canis lupus familiaris (Dog) (Canis familiaris) fertilization [GO:0009566]; flagellated sperm motility [GO:0030317]; spermatid development [GO:0007286] sperm flagellum [GO:0036126] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877] IISKK 9.869999886 0.140031159 589.4724133 20.71338 16.23343 0 0 19.20107 A0A8I3RVC8 A0A8I3RVC8_CANLF Protein kinase C PRKD1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to amino acid starvation [GO:0034198]; cellular response to hydroperoxide [GO:0071447]; defense response to Gram-negative bacterium [GO:0050829]; Golgi organization [GO:0007030]; Golgi vesicle transport [GO:0048193]; intracellular signal transduction [GO:0035556]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy [GO:0010508]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of keratinocyte proliferation [GO:0010837]; regulation of release of sequestered calcium ion into cytosol [GO:0051279] autophagosome membrane [GO:0000421]; cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] ATP binding [GO:0005524]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; phosphatidylinositol 3-kinase activator activity [GO:0141038]; protein serine kinase activity [GO:0106310] ILLFR 22.93000031 0.424728804 662.7139647 17.65361 15.38468 17.05854 0 16.43516 A0A8C0MM77 A0A8C0MM77_CANLF Basic proline-rich protein-like Canis lupus familiaris (Dog) (Canis familiaris) ILLMR 11.85999966 0.036697801 661.9460613 19.73848 0 18.66662 0 18.59735 A0A8C0MDT1 A0A8C0MDT1_CANLF "Keratin, type II cytoskeletal 8 (Cytokeratin-8) (Keratin-8) (Type-II keratin Kb8)" Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; keratin filament [GO:0045095]; nuclear matrix [GO:0016363] INFLR 8.090000153 0.391997973 662.9635992 14.98919 15.64682 16.51092 15.4571 16.12894 A0A8C0PLM8 A0A8C0PLM8_CANLF NSL1 component of MIS12 kinetochore complex Canis lupus familiaris (Dog) (Canis familiaris) mitotic sister chromatid segregation [GO:0000070] kinetochore [GO:0000776] INLDT 7.090000153 0.332391731 574.5735464 16.14379 0 15.3176 14.32998 16.89597 A0A8C0S498 A0A8C0S498_CANLF Coiled-coil serine rich protein 2 CCSER2 Canis lupus familiaris (Dog) (Canis familiaris) IPSQL 5.619999886 0.346876485 557.2939331 18.83541 16.27679 16.3844 16.20031 16.31028 A0A8C0NQS0 A0A8C0NQS0_CANLF Zinc finger FYVE domain-containing protein ZFYVE16 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; early endosome membrane [GO:0031901] 1-phosphatidylinositol binding [GO:0005545]; metal ion binding [GO:0046872] ITCGK 5.820000172 0.328967239 577.1615971 0 15.92605 13.83374 17.70675 13.86467 A0A8C0NIG3 A0A8C0NIG3_CANLF E3 ubiquitin-protein ligase listerin (EC 2.3.2.27) (RING-type E3 ubiquitin transferase listerin) Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567]; rescue of stalled ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116] cytosol [GO:0005829]; RQC complex [GO:1990112] ribosomal large subunit binding [GO:0043023]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] LDFFR 11.72999954 0.335163153 697.3416438 16.90842 17.30827 15.38452 16.92474 17.3564 A0A8C0SXI0 A0A8C0SXI0_CANLF Solute carrier organic anion transporter family member Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transport [GO:0006811] plasma membrane [GO:0005886] transmembrane transporter activity [GO:0022857] LETHR 3.650000095 1.22E-13 655.4117239 15.74938 16.29651 12.95879 16.76968 14.41247 A0A8C0NH27 A0A8C0NH27_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LFFDR 11.03999996 0.136345543 696.3769985 14.54419 15.96702 15.89623 16.15014 15.25495 A0A8C0M9A7 A0A8C0M9A7_CANLF TTL family tubulin polyglutamylase complex subunit L1 TTLL1 Canis lupus familiaris (Dog) (Canis familiaris) cerebellar Purkinje cell differentiation [GO:0021702]; immune response in nasopharyngeal-associated lymphoid tissue [GO:0002395]; mucociliary clearance [GO:0120197]; protein modification process [GO:0036211]; regulation of blastocyst development [GO:0120222]; sperm axoneme assembly [GO:0007288] ciliary basal body [GO:0036064]; extracellular region [GO:0005576]; microtubule [GO:0005874] ATP binding [GO:0005524]; tubulin-glutamic acid ligase activity [GO:0070740] LGFCR 3.640000105 0.41603257 652.6392931 15.65826 13.97126 15.84436 15.81098 15.5329 A0A8C0REK4 A0A8C0REK4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LGGGT 11.60999966 0 404.1181986 14.72924 0 14.93542 18.72287 16.74233 A0A8C0M0C3 A0A8C0M0C3_CANLF Peptidase M12B domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] LLPSS 2.329999924 0.283379946 517.7707971 17.55333 15.63057 0 17.50419 0 A0A8I3NKG3 A0A8I3NKG3_CANLF Mitochondrial ribosomal protein S2 MRPS2 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] small ribosomal subunit [GO:0015935] structural constituent of ribosome [GO:0003735] LPLLP 16.26000023 0.329180117 552.4096193 15.50459 16.25748 16.09811 16.94418 15.21655 A0A8C0T1Q3 A0A8C0T1Q3_CANLF Sideroflexin 5 SFXN5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; mitochondrion [GO:0005739] monoatomic ion transmembrane transporter activity [GO:0015075] LRHPS 2.190000057 0.26579913 609.5946318 14.23045 13.98496 15.32863 15.06949 15.26354 A0A8C0MN04 A0A8C0MN04_CANLF Nuclear RNA export factor Tap RNA-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mRNA export from nucleus [GO:0006406] cytoplasm [GO:0005737]; nucleus [GO:0005634] RNA binding [GO:0003723] LTMSK 6.210000038 0.225338199 578.9380712 13.2314 12.87704 13.35177 11.73673 14.61553 A0A8C0NDG1 A0A8C0NDG1_CANLF "NPL4 homolog, ubiquitin recognition factor" NPLOC4 Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-dependent protein catabolic process [GO:0006511] LTRTT 5.849999905 0.057738214 591.3191359 14.75456 14.55938 12.11329 0 14.75481 A0A8C0LZB9 A0A8C0LZB9_CANLF Tubulin tyrosine ligase like 11 Canis lupus familiaris (Dog) (Canis familiaris) protein modification process [GO:0036211] LVCGR 2.49000001 1.23E-13 604.3198749 9.161356 0 12.62362 13.87344 12.44218 A0A8C0QHC6 A0A8C0QHC6_CANLF Cocaine- and amphetamine-regulated transcript protein CARTPT Canis lupus familiaris (Dog) (Canis familiaris) adult feeding behavior [GO:0008343]; cellular response to starvation [GO:0009267]; chemical synaptic transmission [GO:0007268]; intracellular glucose homeostasis [GO:0001678]; negative regulation of appetite [GO:0032099]; negative regulation of bone resorption [GO:0045779]; neuropeptide signaling pathway [GO:0007218]; positive regulation of blood pressure [GO:0045777]; positive regulation of epinephrine secretion [GO:0032812]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of transmission of nerve impulse [GO:0051971] extracellular space [GO:0005615]; secretory granule [GO:0030141]; synapse [GO:0045202] neuropeptide hormone activity [GO:0005184] MESPR 2.769999981 0.122137063 633.7795993 16.51358 16.7998 16.63256 19.84359 17.38865 A0A8I3Q3D5 A0A8I3Q3D5_CANLF High mobility group box 3 HMGB3 Canis lupus familiaris (Dog) (Canis familiaris) DNA metabolic process [GO:0006259]; innate immune response [GO:0045087]; negative regulation of B cell differentiation [GO:0045578]; negative regulation of myeloid cell differentiation [GO:0045638] chromosome [GO:0005694]; nucleus [GO:0005634] "DNA binding, bending [GO:0008301]; RNA binding [GO:0003723]" MHEAR 3.539999962 0.083453263 643.1766828 0 16.63924 0 15.21239 0 A0A8I3SCU3 A0A8I3SCU3_CANLF Maltase-glucoamylase MGAM Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] membrane [GO:0016020] alpha-glucosidase activity [GO:0090599]; carbohydrate binding [GO:0030246] MILFR 21.63999939 0.054695402 679.4621216 16.8511 16.65637 16.58764 17.09857 17.89829 A0A8C0MQT9 A0A8C0MQT9_CANLF Nucleotide binding protein like Canis lupus familiaris (Dog) (Canis familiaris) iron-sulfur cluster assembly [GO:0016226] ATP binding [GO:0005524]; ATP-dependent FeS chaperone activity [GO:0140663]; iron-sulfur cluster binding [GO:0051536] MMNLK 3.25 0.078021034 652.3408837 16.94028 16.06816 15.0323 15.86549 14.58931 A0A8C0MF01 A0A8C0MF01_CANLF SH3 and cysteine rich domain STAC Canis lupus familiaris (Dog) (Canis familiaris) sarcolemma [GO:0042383] metal ion binding [GO:0046872] MSMCK 9.220000267 0.342408103 672.7843597 16.56521 15.19688 17.5273 16.43463 16.51868 A0A8C0T799 A0A8C0T799_CANLF Myozenin 2 MYOZ2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of transcription by RNA polymerase II [GO:0000122]; sarcomere organization [GO:0045214]; skeletal muscle fiber adaptation [GO:0043503]; skeletal muscle tissue development [GO:0007519] actin cytoskeleton [GO:0015629]; Z disc [GO:0030018] actin binding [GO:0003779]; telethonin binding [GO:0031433] MVKFK 1.539999962 0.109394437 652.4016744 18.46338 17.42336 16.96515 18.08478 17.69377 A0A8C0Q2G0 A0A8C0Q2G0_CANLF IF rod domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] NFSAS 3.380000114 0.100062102 525.3328687 14.79609 16.92072 14.7202 14.89082 15.18548 A0A8C0NHA7 A0A8C0NHA7_CANLF Calpain catalytic domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] calcium-dependent cysteine-type endopeptidase activity [GO:0004198] NILFR 20.79000092 0.084521635 662.7595509 0 18.16373 16.34687 16.61107 17.83633 A0A8C0MFZ5 A0A8C0MFZ5_CANLF Uncharacterized protein CYP46A1 Canis lupus familiaris (Dog) (Canis familiaris) cholesterol catabolic process [GO:0006707] endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane [GO:0016020] cholesterol 24-hydroxylase activity [GO:0033781]; heme binding [GO:0020037]; iron ion binding [GO:0005506] NTLAK 10.25 0.174986588 546.4368978 21.43132 21.28999 20.12529 22.89286 20.98579 A0A8P0TJJ4 A0A8P0TJJ4_CANLF DENN domain containing 1A DENND1A Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] QVCLL 2.359999895 0.033328737 631.3804619 15.10471 15.05227 14.21007 15.97484 15.64035 A0A8C0QEY5 A0A8C0QEY5_CANLF Protein kinase domain-containing protein HIPK1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] RAIAM 10.02999973 0.072512351 576.4193045 15.02952 13.85904 16.81667 14.80606 15.2925 A0A8C0PV66 A0A8C0PV66_CANLF Cyclin dependent kinase 1 CDK1 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; epithelial cell differentiation [GO:0030855]; fibroblast proliferation [GO:0048144]; G2/M transition of mitotic cell cycle [GO:0000086]; microtubule cytoskeleton organization involved in mitosis [GO:1902850]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of apoptotic process [GO:0043066]; phosphorylation [GO:0016310]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of mitochondrial ATP synthesis coupled electron transport [GO:1905448]; positive regulation of mitotic sister chromatid segregation [GO:0062033]; positive regulation of protein localization to nucleus [GO:1900182]; protein localization to kinetochore [GO:0034501]; regulation of circadian rhythm [GO:0042752] centrosome [GO:0005813]; cyclin A2-CDK1 complex [GO:0097122]; cyclin B1-CDK1 complex [GO:0097125]; cytosol [GO:0005829]; midbody [GO:0030496]; mitochondrial matrix [GO:0005759]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; spindle microtubule [GO:0005876] ATP binding [GO:0005524]; chromatin binding [GO:0003682]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; histone kinase activity [GO:0035173]; Hsp70 protein binding [GO:0030544]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353] RISGK 11.31000042 0.297746249 560.9950434 14.83433 13.5816 15.04374 15.03721 15.55725 A0A8C0NSS0 A0A8C0NSS0_CANLF "2-oxoadipate dehydrogenase complex component E1 (2-oxoadipate dehydrogenase, mitochondrial) (Alpha-ketoadipate dehydrogenase) (Dehydrogenase E1 and transketolase domain-containing protein 1) (Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial)" Canis lupus familiaris (Dog) (Canis familiaris) tricarboxylic acid cycle [GO:0006099] oxoglutarate dehydrogenase (succinyl-transferring) activity [GO:0004591]; thiamine pyrophosphate binding [GO:0030976] RQMVR 5.71999979 0.215686512 690.3727974 11.0718 15.07208 13.42347 13.74067 12.90202 A0A8C0NSW0 A0A8C0NSW0_CANLF Olfactory receptor OR4D9C Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] SAMRR 7.099999905 0.153539018 637.4189721 17.03856 14.88825 14.51233 15.23058 15.17044 A0A8C0SEU4 A0A8C0SEU4_CANLF Adhesion G protein-coupled receptor A2 ADGRA2 Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070]; central nervous system development [GO:0007417]; endothelial cell migration [GO:0043542]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of endothelial cell migration [GO:0010595]; regulation of angiogenesis [GO:0045765]; regulation of chemotaxis [GO:0050920]; regulation of establishment of blood-brain barrier [GO:0090210]; sprouting angiogenesis [GO:0002040] cell surface [GO:0009986]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; Wnt signalosome [GO:1990909] G protein-coupled receptor activity [GO:0004930] SETTV 1.570000052 0.120024234 535.237368 14.78306 15.87764 14.59234 15.68672 15.06099 A0A8C0NSE7 A0A8C0NSE7_CANLF RRM domain-containing protein TARDBP Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nucleus [GO:0005634] RNA binding [GO:0003723] SEYIR 3.869999886 0.244010155 667.7795058 14.0389 15.00039 14.56473 14.843 15.60491 A0A8C0N016 A0A8C0N016_CANLF Dystonin DST Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament cytoskeleton organization [GO:0045104] cell projection [GO:0042995]; cytoplasm [GO:0005737]; membrane [GO:0016020]; microtubule [GO:0005874] actin binding [GO:0003779]; calcium ion binding [GO:0005509]; microtubule binding [GO:0008017] SGGSK 1.620000005 0.3674188 435.9697585 15.95845 19.90241 18.30501 17.23392 18.68476 Q88435 NCAP_PIV5 Nucleoprotein (Nucleocapsid protein) (NP) (Protein N) NP N Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) helical viral capsid [GO:0019029]; host cell cytoplasm [GO:0030430]; ribonucleoprotein complex [GO:1990904]; viral nucleocapsid [GO:0019013] RNA binding [GO:0003723]; structural molecule activity [GO:0005198] SGMSR 5.380000114 0.167928455 538.072618 14.66424 16.8082 15.9948 15.2117 16.14589 A0A8C0SNI9 A0A8C0SNI9_CANLF Speedy/RINGO cell cycle regulator family member A SPDYA Canis lupus familiaris (Dog) (Canis familiaris) DNA damage response [GO:0006974]; establishment of protein localization to telomere [GO:0070200]; G1/S transition of mitotic cell cycle [GO:0000082]; male meiotic nuclear division [GO:0007140]; meiotic attachment of telomere to nuclear envelope [GO:0070197]; oogenesis [GO:0048477]; positive regulation of cell population proliferation [GO:0008284]; spermatogenesis [GO:0007283]; telomere capping [GO:0016233] "chromosome, telomeric region [GO:0000781]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; XY body [GO:0001741]" protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901] SGSNR 7.420000076 0.002966982 520.3198865 13.18606 12.34832 14.00337 12.89937 11.52873 A0A8C0M3S1 A0A8C0M3S1_CANLF Fanconi-associated nuclease (EC 3.1.4.1) FAN1 Canis lupus familiaris (Dog) (Canis familiaris) interstrand cross-link repair [GO:0036297] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; nuclease activity [GO:0004518] SKSLS 2.660000086 0.204332109 521.39375 17.71256 15.58179 0 16.58048 16.25776 A0A8C0P4P7 A0A8C0P4P7_CANLF Disintegrin and metalloproteinase domain-containing protein 1a-like Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] SKYVK 6.349999905 0.240031417 624.3644504 16.1342 17.66633 16.49642 15.60525 14.34893 A0A8C0N2J6 A0A8C0N2J6_CANLF SWIM-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] SMFCK 3.450000048 0.292554412 673.2510275 14.32529 15.69945 16.48519 14.85964 15.30161 A0A8C0NYW6 A0A8C0NYW6_CANLF Prostaglandin D2 receptor 2 PTGDR2 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; calcium-mediated signaling [GO:0019722]; chemotaxis [GO:0006935]; negative regulation of male germ cell proliferation [GO:2000255]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745] membrane [GO:0016020] prostaglandin D receptor activity [GO:0004956]; prostaglandin F receptor activity [GO:0004958]; prostaglandin J receptor activity [GO:0001785] SQDER 4.230000019 0.318127561 633.7489673 16.11381 17.33529 16.97499 14.93997 16.90861 A0A8C0LUT2 A0A8C0LUT2_CANLF Protein phosphatase 1 regulatory subunit Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737]; stress fiber [GO:0001725] phosphatase regulator activity [GO:0019208]; protein kinase binding [GO:0019901] SRLMR 3.690000057 0.232901039 677.539989 19.784 22.15231 15.9778 15.85671 15.67326 A0A8C0M7E1 A0A8C0M7E1_CANLF Adenosine A2b receptor (Tetratricopeptide repeat domain 19) TTC19 ADORA2B Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial respiratory chain complex III assembly [GO:0034551] mitochondrion [GO:0005739] SRPLT 4.460000038 0.341714837 573.768303 16.69783 14.84164 14.41655 17.28745 16.302 A0A8C0NAZ5 A0A8C0NAZ5_CANLF Receptor protein-tyrosine kinase (EC 2.7.10.1) ERBB2 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to epidermal growth factor stimulus [GO:0071364]; ERBB2-EGFR signaling pathway [GO:0038134]; ERBB2-ERBB3 signaling pathway [GO:0038133]; ERBB2-ERBB4 signaling pathway [GO:0038135]; heart development [GO:0007507]; immature T cell proliferation in thymus [GO:0033080]; motor neuron axon guidance [GO:0008045]; myelination [GO:0042552]; negative regulation of immature T cell proliferation in thymus [GO:0033088]; neuromuscular junction development [GO:0007528]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; oligodendrocyte differentiation [GO:0048709]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphorylation [GO:0016310]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell growth [GO:0030307]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of translation [GO:0045727]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of microtubule-based process [GO:0032886]; Schwann cell development [GO:0014044]; semaphorin-plexin signaling pathway [GO:0071526]; wound healing [GO:0042060] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ERBB3:ERBB2 complex [GO:0038143]; myelin sheath [GO:0043209]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; presynaptic membrane [GO:0042734]; ruffle membrane [GO:0032587]; semaphorin receptor complex [GO:0002116] ATP binding [GO:0005524]; coreceptor activity [GO:0015026]; ErbB-3 class receptor binding [GO:0043125]; growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; receptor tyrosine kinase binding [GO:0030971]; RNA polymerase I core binding [GO:0001042]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] SSSTR 6.210000038 0.238160812 538.0383248 17.99335 16.51505 16.25249 18.53361 17.54386 A0A8C0Q782 A0A8C0Q782_CANLF Cilia and flagella associated protein 107 CFAP107 Canis lupus familiaris (Dog) (Canis familiaris) SVILA 4.320000172 0.32727501 501.8461922 18.17134 17.56347 19.17617 18.13752 18.00102 A0A8I3N9X4 A0A8I3N9X4_CANLF KLF transcription factor 4 KLF4 Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070]; cellular response to growth factor stimulus [GO:0071363]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to leukemia inhibitory factor [GO:1990830]; defense response to tumor cell [GO:0002357]; epidermal cell differentiation [GO:0009913]; epidermis morphogenesis [GO:0048730]; establishment of skin barrier [GO:0061436]; fat cell differentiation [GO:0045444]; glandular epithelial cell differentiation [GO:0002067]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000342]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of leukocyte adhesion to arterial endothelial cell [GO:1904998]; negative regulation of response to cytokine stimulus [GO:0060761]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gene expression [GO:0010628]; positive regulation of hemoglobin biosynthetic process [GO:0046985]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of sprouting angiogenesis [GO:1903672]; post-embryonic camera-type eye development [GO:0031077]; post-embryonic hemopoiesis [GO:0035166]; regulation of axon regeneration [GO:0048679]; regulation of blastocyst development [GO:0120222]; regulation of cell differentiation [GO:0045595]; response to retinoic acid [GO:0032526]; somatic stem cell population maintenance [GO:0035019]; transcription by RNA polymerase II [GO:0006366] cytosol [GO:0005829]; euchromatin [GO:0000791]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667] "beta-catenin binding [GO:0008013]; chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity [GO:0001010]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]" TASPR 1.970000029 0.308344802 531.1902467 17.6945 17.63947 19.76399 17.25907 15.22341 A0A8I3PI99 TMCO1_CANLF Calcium load-activated calcium channel (CLAC channel) (GEL complex subunit TMCO1) (Transmembrane and coiled-coil domain-containing protein 1) TMCO1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum calcium ion homeostasis [GO:0032469]; ER overload response [GO:0006983]; multi-pass transmembrane protein insertion into ER membrane [GO:0160063] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; multi-pass translocon complex [GO:0160064] calcium channel activity [GO:0005262]; ribosome binding [GO:0043022] TDKYK 10.82999992 0.234680828 655.4777343 15.39797 18.12691 15.05499 18.49689 15.54269 A0A8C0NJ47 A0A8C0NJ47_CANLF Dicarboxylate carrier SLC25A8 (Mitochondrial uncoupling protein 2) (Solute carrier family 25 member 8) UCP2 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to glucose stimulus [GO:0071333]; glutamine metabolic process [GO:0006541]; glycolytic process [GO:0006096]; macrophage differentiation [GO:0030225]; mitochondrial fission [GO:0000266]; mitochondrial transmembrane transport [GO:1990542]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of cold-induced thermogenesis [GO:0120162]; reactive oxygen species metabolic process [GO:0072593]; regulation of mitochondrial membrane potential [GO:0051881]; response to hypoxia [GO:0001666] mitochondrial membrane [GO:0031966] antiporter activity [GO:0015297]; chloride transmembrane transporter activity [GO:0015108]; L-aspartate transmembrane transporter activity [GO:0015183]; malate transmembrane transporter activity [GO:0015140]; oxaloacetate transmembrane transporter activity [GO:0015131]; phosphate ion uniporter activity [GO:0140787]; protein homodimerization activity [GO:0042803]; proton transmembrane transporter activity [GO:0015078]; secondary active sulfate transmembrane transporter activity [GO:0008271] TEGPR 3.849999905 0.228667482 559.032972 20.22954 17.28163 17.13297 16.51065 16.46385 A0A8C0RT78 A0A8C0RT78_CANLF Multimerin 1 MMRN1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of response to stimulus [GO:0048583] TGKFR 11.57999992 0.436776468 608.6078425 17.86685 17.34111 17.02092 16.20285 17.02403 A0A8I3P571 A0A8I3P571_CANLF Zinc finger FYVE domain-containing protein ZFYVE9 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; early endosome membrane [GO:0031901] 1-phosphatidylinositol binding [GO:0005545]; metal ion binding [GO:0046872] TGSAR 7.389999866 0.351686705 490.4552171 16.4326 19.36283 17.22782 21.00373 16.60366 A0A8C0S636 A0A8C0S636_CANLF Zinc finger protein 711 ZNF711 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] THTGR 7.079999924 0.373016818 572.3205299 17.05163 16.32693 15.52784 18.20634 0 A0A8C0NP72 A0A8C0NP72_CANLF Bromodomain PHD finger transcription factor Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] NURF complex [GO:0016589] metal ion binding [GO:0046872] THVYR 11.75 0.420600028 675.8505303 17.16829 17.12982 15.73681 16.30964 17.20713 A0A8C0NCG0 A0A8C0NCG0_CANLF Family with sequence similarity 83 member B FAM83B Canis lupus familiaris (Dog) (Canis familiaris) cell population proliferation [GO:0008283]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742] cytoplasm [GO:0005737]; membrane [GO:0016020] epidermal growth factor receptor binding [GO:0005154]; phosphatidylinositol 3-kinase catalytic subunit binding [GO:0036313]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; protein kinase binding [GO:0019901] TLYAR 2.119999886 0.307434674 624.0903211 17.74664 15.84291 16.44219 15.68248 13.76735 A0A8C0R998 A0A8C0R998_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] TPALH 3.029999971 0 537.336105 15.87449 14.76318 14.53052 13.94736 15.68912 A0A8C0M197 A0A8C0M197_CANLF D(1B) dopamine receptor (D(5) dopamine receptor) (Dopamine D5 receptor) Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189] plasma membrane [GO:0005886]; synapse [GO:0045202] dopamine neurotransmitter receptor activity [GO:0004952]; G protein-coupled receptor activity [GO:0004930] TPGGR 2.890000105 0.295384758 488.1185572 14.60202 15.05323 15.8559 14.68202 14.05687 A0A8C0RA43 A0A8C0RA43_CANLF Histone chaperone domain-containing protein HIRIP3 Canis lupus familiaris (Dog) (Canis familiaris) TSASR 5.590000153 0.006007021 520.3239131 13.75138 11.75742 12.89233 13.36242 13.49356 A0A8I3NLE2 A0A8I3NLE2_CANLF Rho related BTB domain containing 3 RHOBTB3 Canis lupus familiaris (Dog) (Canis familiaris) "male gonad development [GO:0008584]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; small GTPase binding [GO:0031267] TYLGR 2.700000048 0 608.3142233 15.20813 16.48132 0 0 0 A0A8C0M2J1 A0A8C0M2J1_CANLF C2H2-type domain-containing protein LOC100682666 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872] VHSAK 3.569999933 0 541.2204088 12.42936 12.93767 12.61119 10.75551 11.37185 A0A8C0TLN5 A0A8C0TLN5_CANLF Transcription elongation regulator 1 like TCERG1L Canis lupus familiaris (Dog) (Canis familiaris) RNA polymerase binding [GO:0070063]; transcription coregulator activity [GO:0003712] VTHFR 7.619999886 0.289307807 658.748405 14.90456 15.75761 15.07809 14.65483 15.31737 A0A8C0RPR2 A0A8C0RPR2_CANLF Zinc finger CCHC-type and RNA-binding motif-containing protein 1 (U11/U12 small nuclear ribonucleoprotein 31 kDa protein) ZCRB1 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" U12-type spliceosomal complex [GO:0005689] RNA binding [GO:0003723]; zinc ion binding [GO:0008270] VTIMK 5.059999943 0 591.3200557 14.02342 0 15.15612 15.88656 15.03616 A0A8C0T877 A0A8C0T877_CANLF FYVE-type zinc finger domain-containing protein MOBP Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] YSICK 2.960000038 0 670.2171033 12.77351 8.700318 14.25424 0 12.78831 A0A8I3NKI7 A0A8I3NKI7_CANLF Non-histone chromosomal protein HMG-17 (High mobility group nucleosome-binding domain-containing protein 2) DHDDS Canis lupus familiaris (Dog) (Canis familiaris) chromatin [GO:0000785]; nucleus [GO:0005634] nucleosomal DNA binding [GO:0031492] HAPSPPR 7.059999943 0.272268382 761.3774977 15.7794 14.50973 16.67519 14.8165 16.08612 A0A8C0NBQ4 A0A8C0NBQ4_CANLF Non-specific serine/threonine protein kinase Canis lupus familiaris (Dog) (Canis familiaris) HGSAQLR 7.739999771 0.301887901 768.3002716 15.40024 16.4918 17.28531 16.13456 16.05325 P11207 V_PIV5 Non-structural protein V P/V Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) disruption by virus of host JAK-STAT cascade via inhibition of STAT1 activity [GO:0039563]; disruption by virus of host JAK-STAT cascade via inhibition of STAT2 activity [GO:0039564]; suppression by virus of host type I interferon-mediated signaling pathway [GO:0039502]; suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity [GO:0039554] host cell cytoplasm [GO:0030430] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; ubiquitin ligase-substrate adaptor activity [GO:1990756] GSVGGGAKPK 9.579999924 0 857.5152346 12.86704 15.984 11.87388 10.774 12.97507 A0A8C0RIJ0 A0A8C0RIJ0_CANLF Nuclear apoptosis-inducing factor 1 NAIF1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cell growth [GO:0030308]; regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902108] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] MAVPAKK 4.170000076 0.096061082 761.3158533 16.89047 17.73547 16.95157 15.31433 16.65523 A0A8C0NUP0 A0A8C0NUP0_CANLF Nuclear prelamin A recognition factor NARF Canis lupus familiaris (Dog) (Canis familiaris) lamin filament [GO:0005638]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] lamin binding [GO:0005521] YQGPGLPALSR 1.210000038 0.23232392 1157.664781 15.34791 15.26155 14.33013 15.45234 15.30776 A0A8I3RRF8 A0A8I3RRF8_CANLF "Nuclear protein, coactivator of histone transcription" NPAT Canis lupus familiaris (Dog) (Canis familiaris) cell cycle G1/S phase transition [GO:0044843]; in utero embryonic development [GO:0001701]; positive regulation of transcription by RNA polymerase II [GO:0045944] Cajal body [GO:0015030]; cytoplasm [GO:0005737]; Gemini of coiled bodies [GO:0097504] transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] KQGTSSNSK 4.78000021 0.334874327 935.7576623 15.49038 14.44044 16.51001 16.94962 15.26348 A0A8C0RBH9 A0A8C0RBH9_CANLF Nuclear receptor binding SET domain protein 1 NSD1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893]; regulation of peptidyl-serine phosphorylation [GO:0033135] nucleus [GO:0005634] histone H3K36 methyltransferase activity [GO:0046975]; nuclear androgen receptor binding [GO:0050681]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270] DMHDSKTK 5.599999905 0.335909786 961.3541823 17.92171 15.78244 17.03785 16.95663 15.80025 A0A8C0S485 A0A8C0S485_CANLF Nuclear receptor binding SET domain protein 3 NSD3 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] histone H3K27 dimethyltransferase activity [GO:0140952]; histone H3K27 trimethyltransferase activity [GO:0140951]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K4 dimethyltransferase activity [GO:0140946]; metal ion binding [GO:0046872]; transcription regulator activator activity [GO:0140537] NVASKAEVK 4.079999924 0.306028216 945.9401365 17.11348 15.71205 15.35524 15.59369 16.55179 A0A8C0PDK1 A0A8C0PDK1_CANLF Nuclear transcription factor Y subunit gamma (CAAT box DNA-binding protein subunit C) (Nuclear transcription factor Y subunit C) NFYC Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982] VQELPLARIK 6.460000038 0.499256456 1168.365184 18.16229 15.77359 11.3166 14.60313 16.91911 A0A8C0PY26 A0A8C0PY26_CANLF Nucleolar GTP-binding protein 1 GTPBP4 Canis lupus familiaris (Dog) (Canis familiaris) "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of DNA replication [GO:0008156]; negative regulation of protein ubiquitination [GO:0031397]; protein stabilization [GO:0050821]" cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; preribosome binding [GO:1990275] DFIDLTLSK 3.769999981 0.436092847 1050.959446 15.9859 15.09464 14.40269 15.19981 15.26861 A0A8I3PHD1 A0A8I3PHD1_CANLF Nucleolar and coiled-body phosphoprotein 1 NOLC1 Canis lupus familiaris (Dog) (Canis familiaris) neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; nucleolus organization [GO:0007000]; regulation of translation [GO:0006417] Cajal body [GO:0015030]; fibrillar center [GO:0001650] protein heterodimerization activity [GO:0046982]; protein-macromolecule adaptor activity [GO:0030674] GLILPK 1.529999971 0 641.5131106 13.1971 12.06755 12.72924 13.20172 15.51891 A0A8P0N8V7 A0A8P0N8V7_CANLF Nucleolar complex associated 4 homolog NOC4L Canis lupus familiaris (Dog) (Canis familiaris) ribosome biogenesis [GO:0042254] nuclear membrane [GO:0031965] HGAGPRPGWR 2.50999999 0.092186573 1090.649405 14.8695 13.16924 16.44341 14.36976 14.94664 A0A8I3N5V8 A0A8I3N5V8_CANLF Nucleolar protein 16 LOC100683946 Canis lupus familiaris (Dog) (Canis familiaris) MGLAMDPNK 3.950000048 0.094562634 992.1726833 17.46731 19.31256 16.31989 15.58892 0 A0A8C0M1X2 A0A8C0M1X2_CANLF Nucleolar protein 4 NOL4 Canis lupus familiaris (Dog) (Canis familiaris) QVLYVPVK 2.75999999 0.271698154 945.8452061 19.01599 20.1052 19.09805 17.45051 18.28366 A0A8I3P8X1 A0A8I3P8X1_CANLF Nucleolar protein 4 like NOL4L Canis lupus familiaris (Dog) (Canis familiaris) HVESSAEPGKAPK 10.10999966 0.000595578 1335.622501 0 11.32864 0 16.42473 16.98913 A0A8C0TFC9 A0A8C0TFC9_CANLF Nucleoplasmin core domain-containing protein OGA NPM3 Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364]; rRNA transcription [GO:0009303] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; nucleolus [GO:0005730] MGGAGTR 3.519999981 0.185912224 648.6923838 16.78914 15.49534 14.9449 15.20339 15.66087 P04865 NCAP_CDVO Nucleoprotein (Protein N) (Nucleocapsid protein) N Canine distemper virus (strain Onderstepoort) (CDV) helical viral capsid [GO:0019029]; host cell cytoplasm [GO:0030430]; ribonucleoprotein complex [GO:1990904]; viral nucleocapsid [GO:0019013] RNA binding [GO:0003723]; structural molecule activity [GO:0005198] MRMLTK 4.179999828 0.44549188 780.1270322 15.98789 15.07113 17.92813 15.89435 16.09036 A0A8C0NSB2 A0A8C0NSB2_CANLF OTU deubiquitinase with linear linkage specificity like OTULINL Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] MIDLKTLEGSVSGEK 2.339999914 0.721405275 1608.42113 0 18.22491 18.68151 16.63611 0 Q70ZB5 Q70ZB5_CANLF Olfactory receptor OR12C09 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IVSTICR 8.140000343 0.318845971 847.6828471 17.14253 15.51809 16.04762 16.26258 15.34188 Q70Z78 Q70Z78_CANLF Olfactory receptor OR16F03 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] olfactory receptor activity [GO:0004984] EEGTFNKGMAVLITSITPLL 4.929999828 0.28664803 2149.361661 18.81311 15.65977 0 19.9611 15.70835 A0A8C0PVS4 A0A8C0PVS4_CANLF Olfactory receptor LOC608349 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ARSAAGR 3.819999933 0.30079914 687.7320305 16.02119 0 16.5006 14.34199 16.19552 A0A8C0MB48 A0A8C0MB48_CANLF Olfactory receptor OR10AG63 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] SSHSTGMDK 8.609999657 0.370473857 964.0685681 14.48166 16.37423 15.57775 15.6294 0 A0A8I3PVY2 A0A8I3PVY2_CANLF Olfactory receptor OR4C32 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] NYSAEGKR 13.82999992 0.29400205 925.1657508 17.02198 15.42895 15.168 14.46994 15.61407 A0A8C0YZ57 A0A8C0YZ57_CANLF Olfactory receptor OR5G1B Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ADGNHTR 1.450000048 0 770.723827 15.41059 14.20983 14.08659 12.94203 0 A0A8I3NYF8 A0A8I3NYF8_CANLF Olfactory receptor OR5H16 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FLNKMDTK 1.480000019 0.181754546 997.2194501 13.00149 16.50061 14.0681 15.64344 14.96875 A0A8I3S1J3 A0A8I3S1J3_CANLF Olfactory receptor OR7A73 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IVASILKISSSGGQYK 5.929999828 0.705013363 1650.774792 18.00531 16.65364 0 16.65176 16.8983 A0A8C0PB98 A0A8C0PB98_CANLF Olfactory receptor OR7D7 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] MSSAAGK 8.029999733 0.214541089 666.4988577 21.5615 19.1882 18.79089 19.64208 18.04661 A0A8C0SS73 A0A8C0SS73_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] YVAICNPLHYSMKMSR 2.230000019 0.205262831 2001.610372 0 14.03468 17.4596 13.71754 14.91623 A0A8P0N5P1 A0A8P0N5P1_CANLF Olfactory receptor family 13 subfamily C member 8 OR13C8 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IPSTEGK 4.239999771 1.23E-13 731.3152746 14.53956 15.64532 16.4242 0 15.21021 A0A8C0TJ54 A0A8C0TJ54_CANLF Olfactory receptor family 52 subfamily X member 3 OR52X3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] EHVLRVLR 4.480000019 0.27205065 1020.914418 16.5602 12.24403 15.2632 13.57822 12.47106 A0A8C0N6A5 A0A8C0N6A5_CANLF Origin recognition complex subunit 1 ORC1 Canis lupus familiaris (Dog) (Canis familiaris) DNA replication [GO:0006260] nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; DNA binding [GO:0003677] SRPTPSHPATPRAK 6.659999847 0.726582262 1504.485649 0 17.3926 0 19.82195 15.17523 A0A8C0MUC9 A0A8C0MUC9_CANLF Ornithine decarboxylase antizyme 3 Canis lupus familiaris (Dog) (Canis familiaris) ornithine decarboxylase inhibitor activity [GO:0008073] ESLTATLEYVEEK 2.789999962 0.296307524 1511.625206 16.99244 15.92969 0 18.07128 0 A0A8C0LQT4 A0A8C0LQT4_CANLF Outer dense fiber protein 2 (Cenexin) (Outer dense fiber of sperm tails protein 2) ODF2 Canis lupus familiaris (Dog) (Canis familiaris) centriole [GO:0005814]; cilium [GO:0005929]; spindle pole [GO:0000922] MSASSSGGSPR 4.28000021 0 1038.264033 16.19447 17.29139 0 17.74294 17.5095 A0A8I3PSY3 A0A8I3PSY3_CANLF Oxygen-regulated protein 1 RP1 Canis lupus familiaris (Dog) (Canis familiaris) axoneme assembly [GO:0035082]; cellular response to light stimulus [GO:0071482]; intracellular signal transduction [GO:0035556]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of non-motile cilium assembly [GO:1902857]; retinal cone cell development [GO:0046549]; retinal rod cell development [GO:0046548] axoneme [GO:0005930]; ciliary tip [GO:0097542]; microtubule associated complex [GO:0005875]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750] microtubule binding [GO:0008017] TIEKLYSK 12.23999977 0.275100187 981.1254555 17.46837 18.80903 18.34436 17.06458 17.21266 A0A8C0NBF8 A0A8C0NBF8_CANLF PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (EC 3.1.13.4) (Inactive ubiquitin carboxyl-terminal hydrolase 52) (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 2) (PAN deadenylation complex subunit 2) PAN2 Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606] nucleus [GO:0005634]; P-body [GO:0000932]; PAN complex [GO:0031251] metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; poly(A)-specific ribonuclease activity [GO:0004535] VTIKYSK 14.09000015 0.281612951 837.847609 21.21541 17.96114 18.51982 18.95182 15.59169 A0A8C0N4J4 A0A8C0N4J4_CANLF PCNA-interacting partner (PARP-1 binding protein) (PARP1-binding protein) PARPBP Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of double-strand break repair via homologous recombination [GO:2000042] cytoplasm [GO:0005737]; nucleus [GO:0005634] MQLIKGQNSR 4.360000134 0.023391428 1175.039879 14.88676 13.43935 12.86816 9.898242 10.09838 A0A8C0N1R6 A0A8C0N1R6_CANLF PH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) TLDRPAK 3.880000114 0.232740255 800.7421368 0 12.47998 15.53732 15.95338 15.75449 A0A8C0N1F2 A0A8C0N1F2_CANLF PH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) FERLPPR 1.320000052 0.325998162 914.8229038 13.23634 14.63661 14.7689 14.86479 14.13154 A0A8C0Q271 A0A8C0Q271_CANLF PHD-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872]; methylated histone binding [GO:0035064] HLFGLR 2.309999943 0.238633226 742.9549468 18.50098 17.23852 17.421 16.67686 16.95219 A0A8C0LV53 A0A8C0LV53_CANLF PNK FHA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [GO:0046404]; polynucleotide 3'-phosphatase activity [GO:0046403] RGGASVVGGAK 1.169999957 0.241163468 958.8512633 14.15624 14.55183 15.90305 20.55975 14.66943 A0A8C0PKX2 A0A8C0PKX2_CANLF PPFIA binding protein 1 PPFIBP1 Canis lupus familiaris (Dog) (Canis familiaris) KESSDGEK 5.949999809 0.065036818 879.3211216 14.44342 15.80238 17.05021 15.55012 16.86735 A0A8C0MQY4 A0A8C0MQY4_CANLF PR/SET domain 14 PRDM14 Canis lupus familiaris (Dog) (Canis familiaris) cell fate specification [GO:0001708]; cell morphogenesis [GO:0000902]; embryo implantation [GO:0007566]; fertilization [GO:0009566]; fibroblast growth factor receptor signaling pathway [GO:0008543]; germ-line stem cell population maintenance [GO:0030718]; homeostasis of number of cells within a tissue [GO:0048873]; inactivation of paternal X chromosome by genomic imprinting [GO:0060818]; inner cell mass cell fate commitment [GO:0001827]; methylation [GO:0032259]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of flagellated sperm motility [GO:1902093]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of DNA methylation [GO:0044030] nucleoplasm [GO:0005654] chromatin DNA binding [GO:0031490]; methyltransferase activity [GO:0008168]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977] QTTFGELR 9.859999657 0.170253181 950.3922303 14.82023 14.38043 16.04766 15.31898 14.24019 Q9TSC5 Q9TSC5_CANLF PROSTROMELYSIN Canis lupus familiaris (Dog) (Canis familiaris) KXHLTYR 14.07999992 0.267069936 978.8839922 13.45744 14.56145 12.41264 0 13.529 A0A8C0MRQ9 A0A8C0MRQ9_CANLF PX domain-containing protein PXDC1 Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol binding [GO:0035091] NDNVHK 12.07999992 0.233718527 727.0813244 0 12.38676 11.67213 0 13.58096 A0A8C0M6R3 A0A8C0M6R3_CANLF Paired box protein Pax-9 PAX9 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677] GALEQEAK 6.659999847 0.357418083 845.0747525 18.07944 15.00308 16.16255 15.97074 16.36058 A0A8I3N655 A0A8I3N655_CANLF Palmitoyltransferase (EC 2.3.1.225) ZDHHC17 Canis lupus familiaris (Dog) (Canis familiaris) axonogenesis [GO:0007409]; lipoprotein transport [GO:0042953]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of neurotrophin TRK receptor signaling pathway [GO:0051386]; regulation of programmed cell death [GO:0043067] Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660] identical protein binding [GO:0042802]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; signaling receptor binding [GO:0005102] KPVRSK 8.779999733 0.292166403 714.0356194 14.64461 14.52055 16.66792 15.87998 15.11929 A0A8C0PDL9 A0A8C0PDL9_CANLF Palmitoyltransferase (EC 2.3.1.225) ZDHHC20 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] palmitoyltransferase activity [GO:0016409] AAAGEGEGGGGAGRAWAR 1.730000019 2.49E-13 1600.630415 15.93826 0 16.42717 14.76263 15.21215 A0A8C0Z2A1 A0A8C0Z2A1_CANLF Pannexin PANX Canis lupus familiaris (Dog) (Canis familiaris) monoatomic cation transport [GO:0006812]; monoatomic ion transmembrane transport [GO:0034220]; positive regulation of interleukin-1 production [GO:0032732] gap junction [GO:0005921]; plasma membrane [GO:0005886] channel activity [GO:0015267] SYNRSIR 10.93999958 0.207788792 894.4756655 14.24839 14.98383 15.84208 14.34596 15.5537 A0A8I3S4L5 A0A8I3S4L5_CANLF Parathyroid hormone (Parathyrin) PTH Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; bone mineralization [GO:0030282]; homeostasis of number of cells within a tissue [GO:0048873]; intracellular calcium ion homeostasis [GO:0006874]; magnesium ion homeostasis [GO:0010960]; negative regulation of apoptotic process in bone marrow cell [GO:0071866]; negative regulation of gene expression [GO:0010629]; phosphate ion homeostasis [GO:0055062]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cell proliferation in bone marrow [GO:0071864]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; positive regulation of osteoclast proliferation [GO:0090290]; positive regulation of signal transduction [GO:0009967]; positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription by RNA polymerase II [GO:0006366] extracellular space [GO:0005615] hormone activity [GO:0005179]; peptide hormone receptor binding [GO:0051428]; type 1 parathyroid hormone receptor binding [GO:0031857] SDGKPVK 1.690000057 0.275082301 728.9125508 14.2125 14.06301 17.05693 14.43147 15.5505 A0A8I3NZN1 A0A8I3NZN1_CANLF Pellino E3 ubiquitin protein ligase family member 3 PELI3 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; protein polyubiquitination [GO:0000209]; regulation of Toll signaling pathway [GO:0008592] ubiquitin protein ligase activity [GO:0061630] SGSGAEQGR 4.460000038 0.366413313 846.7816108 18.29709 14.60239 14.95248 14.30936 16.47068 A0A8C0T0W7 A0A8C0T0W7_CANLF Peptidase M20 dimerisation domain-containing protein PM20D1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] metal ion binding [GO:0046872]; peptidase activity [GO:0008233] ETSIGILAAAISR 7.739999771 0.361984994 1301.589079 0 16.44285 17.97467 15.2448 13.21886 A0A8C0SVG2 A0A8C0SVG2_CANLF Peptidase S1 domain-containing protein LOC100684662 LOC609278 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] QLILHYR 5.090000153 0.075774177 943.5953622 14.2111 13.7699 13.68929 16.93418 12.71051 A0A8C0PKE6 A0A8C0PKE6_CANLF Peptidase S1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] GPSLCVPGDSGGPLVCEFR 4.230000019 0.664262363 2004.044451 19.18524 20.11048 17.86424 21.84609 0 A0A8C0NJ91 A0A8C0NJ91_CANLF Peptidase S1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] SWAQYK 14.60999966 0.341184722 782.1608119 17.39419 16.08908 15.35195 20.03562 19.73267 A0A8C0LZJ5 A0A8C0LZJ5_CANLF Peptidase S1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] VLGCGRR 8.989999771 0.149340431 818.1896264 15.11434 16.37093 15.47293 16.92283 15.64409 A0A8C0MV60 A0A8C0MV60_CANLF Peptidase S1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular region [GO:0005576]; membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] TPMETFKK 6.199999809 0.317839646 982.6543581 16.36413 15.53858 12.89166 14.9228 14.64293 A0A8I3P808 A0A8I3P808_CANLF Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) NKTR Canis lupus familiaris (Dog) (Canis familiaris) protein folding [GO:0006457] peptidyl-prolyl cis-trans isomerase activity [GO:0003755] LNTPFK 8.789999962 0.394088138 718.1189063 16.91828 0 15.05168 17.22342 16.18321 A0A8C0TGS0 A0A8C0TGS0_CANLF Period circadian protein homolog 2 (Circadian clock protein PERIOD 2) Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] VSQHSCSRDTAGAAR 1.659999967 0.786145328 1602.893884 15.90904 16.07586 16.79649 18.20881 17.10985 A0A8I3PUP1 A0A8I3PUP1_CANLF Period circadian regulator 1 PER1 Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; circadian regulation of translation [GO:0097167]; entrainment of circadian clock by photoperiod [GO:0043153]; negative regulation of glucocorticoid receptor signaling pathway [GO:2000323]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of hair cycle [GO:0042634]; regulation of sodium ion transport [GO:0002028]; response to cAMP [GO:0051591] cytosol [GO:0005829]; nucleoplasm [GO:0005654] chromatin DNA binding [GO:0031490]; DNA-binding transcription factor binding [GO:0140297]; E-box binding [GO:0070888]; kinase binding [GO:0019900]; ubiquitin protein ligase binding [GO:0031625] ARPMPRPR 3.660000086 1.22E-13 995.9127437 14.04681 15.1397 12.1019 14.37362 13.36022 A0A8I3PVQ1 A0A8I3PVQ1_CANLF Periostin POSTN Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] LLQEGQHV 13.09000015 0.052822749 922.4139289 14.9681 14.33358 16.50436 14.84121 14.16683 A0A8C0TQY1 A0A8C0TQY1_CANLF Peripherin PRPH Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] structural molecule activity [GO:0005198] DVDDATLSR 7.039999962 0.067554486 991.1596026 13.3071 16.23543 17.41891 15.51815 16.4277 A0A8C0NU61 A0A8C0NU61_CANLF Peroxisome assembly protein 12 (Peroxin-12) PEX12 Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to reactive oxygen species [GO:0034614]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein polyubiquitination [GO:0000209]" peroxisomal membrane [GO:0005778] ubiquitin ligase activator activity [GO:1990757]; zinc ion binding [GO:0008270] VNDTVLATSGYVFCYR 3.859999895 2.46E-13 1864.180988 13.55163 0 15.31902 15.199 18.90795 A0A8C0SUB0 A0A8C0SUB0_CANLF Phenylalanine--tRNA ligase beta subunit B1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) phenylalanyl-tRNA aminoacylation [GO:0006432] phenylalanine-tRNA ligase activity [GO:0004826] QSTLVILK 2.579999924 0.304934372 901.1182841 14.43264 12.90589 16.08836 14.71868 16.13048 A0A8C0YW06 A0A8C0YW06_CANLF Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) FARSB Canis lupus familiaris (Dog) (Canis familiaris) phenylalanyl-tRNA aminoacylation [GO:0006432] cytoplasm [GO:0005737] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; phenylalanine-tRNA ligase activity [GO:0004826]; RNA binding [GO:0003723] CSEFLSLR 3.660000086 0.024611325 1011.342688 14.37406 10.42914 12.87098 12.31147 10.45914 A0A8C0TQA2 A0A8C0TQA2_CANLF "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Phosphatase and tensin homolog)" PTEN Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; phosphatidylinositol dephosphorylation [GO:0046856] cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; PML body [GO:0016605]; postsynaptic density [GO:0014069] "inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity [GO:0051717]; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314]; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [GO:0051800]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; protein tyrosine phosphatase activity [GO:0004725]" LEGVYR 2.769999981 0.390562473 735.7813976 15.27614 15.03384 13.19234 15.50943 15.18542 A0A8C0LXY3 A0A8C0LXY3_CANLF Phosphodiesterase (EC 3.1.4.-) PDE4D Canis lupus familiaris (Dog) (Canis familiaris) cAMP catabolic process [GO:0006198]; negative regulation of cAMP-mediated signaling [GO:0043951]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of type II interferon production [GO:0032729]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; T cell receptor signaling pathway [GO:0050852] calcium channel complex [GO:0034704]; cytosol [GO:0005829]; plasma membrane [GO:0005886] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; ATPase binding [GO:0051117]; cAMP binding [GO:0030552]; metal ion binding [GO:0046872]; scaffold protein binding [GO:0097110]; transmembrane transporter binding [GO:0044325]" MEAEGSSVPAR 5.920000076 0.099408605 1149.491589 0 0 17.7438 0 15.62309 A0A8C0N3H2 A0A8C0N3H2_CANLF Phosphoinositide 3-kinase regulatory subunit 5 PIK3R5 Canis lupus familiaris (Dog) (Canis familiaris) "centriolar satellite [GO:0034451]; cytosol [GO:0005829]; nucleus [GO:0005634]; phosphatidylinositol 3-kinase complex, class IB [GO:0005944]; plasma membrane [GO:0005886]" 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935] ASGPGSK 1.179999948 0.299129739 601.6238577 15.04911 16.66727 13.19081 14.1674 0 A0A8C0MV61 A0A8C0MV61_CANLF Phosphoinositide phospholipase C (EC 3.1.4.11) PLCE1 Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042]; small GTPase mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol phospholipase C activity [GO:0004435] FPGSCEGMR 1.789999962 0.279201086 1055.647517 13.65796 15.88422 13.6947 15.55349 16.70795 A0A8C0N4W6 A0A8C0N4W6_CANLF Phosphoinositide phospholipase C (EC 3.1.4.11) PLCL1 Canis lupus familiaris (Dog) (Canis familiaris) "gamma-aminobutyric acid signaling pathway [GO:0007214]; intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042]; negative regulation of cold-induced thermogenesis [GO:0120163]; regulation of synaptic transmission, GABAergic [GO:0032228]" phosphatidylinositol phospholipase C activity [GO:0004435] EAIDMR 5.46999979 0.279645628 749.6805842 12.8952 14.59644 15.69856 15.82226 15.35367 A0A8I3PIB6 A0A8I3PIB6_CANLF Phosphoinositide phospholipase C (EC 3.1.4.11) PLCL2 Canis lupus familiaris (Dog) (Canis familiaris) "B cell proliferation involved in immune response [GO:0002322]; B-1a B cell differentiation [GO:0002337]; gamma-aminobutyric acid signaling pathway [GO:0007214]; intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of cold-induced thermogenesis [GO:0120163]; regulation of synaptic transmission, GABAergic [GO:0032228]" "GABA receptor binding [GO:0050811]; inositol 1,4,5 trisphosphate binding [GO:0070679]; phosphatidylinositol phospholipase C activity [GO:0004435]" ALKMGCR 6.010000229 0.166420611 850.5796862 15.49665 15.89723 16.26417 17.40454 17.20994 A0A8I3PD50 A0A8I3PD50_CANLF Phosphoinositide-3-kinase regulatory subunit 3 LOC100856339 Canis lupus familiaris (Dog) (Canis familiaris) VKSMTGYMK 3.339999914 0.438303754 1061.3757 20.05617 0 0 17.05923 17.67162 A0A8C0MLV5 A0A8C0MLV5_CANLF Phospholipase A2 (EC 3.1.1.4) PLA2G2F Canis lupus familiaris (Dog) (Canis familiaris) arachidonic acid secretion [GO:0050482]; lipid catabolic process [GO:0016042]; phospholipid metabolic process [GO:0006644] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; phospholipase A2 activity [GO:0004623] YMVEAITGR 6.710000038 0.26840655 1056.802466 9.395417 16.63718 11.55072 13.22843 14.92092 A0A8C0TR65 A0A8C0TR65_CANLF Phospholipase A2 group XIIA PLA2G12A Canis lupus familiaris (Dog) (Canis familiaris) arachidonic acid secretion [GO:0050482]; lipid catabolic process [GO:0016042]; phospholipid metabolic process [GO:0006644] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; phospholipase A2 activity [GO:0004623] ATLKTIR 8.149999619 0.258150143 802.9645762 14.37693 14.29943 0 9.590219 12.28804 A0A8C0Q3Y2 A0A8C0Q3Y2_CANLF Phospholipid-transporting ATPase (EC 7.6.2.1) ATP10A Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of membrane tubulation [GO:1903527] endoplasmic reticulum [GO:0005783]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; glycosylceramide flippase activity [GO:0140351]; magnesium ion binding [GO:0000287]; phosphatidylcholine flippase activity [GO:0140345] VGDFVR 1.25999999 1.22E-13 693.3381212 14.62051 14.94212 14.95921 14.9301 15.41892 A0A8P0P5E3 A0A8P0P5E3_CANLF Phospholipid-transporting ATPase (EC 7.6.2.1) ATP10D Canis lupus familiaris (Dog) (Canis familiaris) phospholipid transport [GO:0015914] membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] GGCASK 5 0.301197528 579.8512226 20.98517 19.3721 19.10344 21.67484 20.67053 A0A8I3P728 A0A8I3P728_CANLF Phospholipid-transporting ATPase (EC 7.6.2.1) ATP8A2 Canis lupus familiaris (Dog) (Canis familiaris) phospholipid transport [GO:0015914] Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] GADNVIFDR 7.070000172 0.198554939 1007.528387 16.15621 13.22 14.26577 15.4989 15.09593 R9Q7P1 R9Q7P1_MOKV Phosphoprotein (Protein P) (Protein M1) P Mokola virus (MOKV) disruption by virus of host JAK-STAT cascade via inhibition of STAT1 activity [GO:0039563]; disruption by virus of host JAK-STAT cascade via inhibition of STAT2 activity [GO:0039564]; suppression by virus of host type I interferon-mediated signaling pathway [GO:0039502]; viral transcription [GO:0019083] cytoplasm [GO:0005737]; host cell cytoplasm [GO:0030430]; virion component [GO:0044423] RNA-dependent RNA polymerase activity [GO:0003968] LNMDDIVK 9.920000076 1.23E-13 948.6265131 16.57188 16.96708 13.6609 0 15.77384 A0A8I3NUU9 A0A8I3NUU9_CANLF Phosphotyrosine interaction domain containing 1 PID1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to fatty acid [GO:0071398]; cellular response to interleukin-6 [GO:0071354]; cellular response to leptin stimulus [GO:0044320]; cellular response to tumor necrosis factor [GO:0071356]; mitochondrion organization [GO:0007005]; negative regulation of ATP biosynthetic process [GO:2001170]; negative regulation of glucose import [GO:0046325]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of fat cell proliferation [GO:0070346]; positive regulation of gene expression [GO:0010628]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mitochondrial membrane potential [GO:0051881] cytoplasm [GO:0005737] TFHSMK 2.700000048 0.405984843 766.9127984 15.97165 16.2048 18.10793 16.67366 15.96688 Q6VAH8 Q6VAH8_CANLF Plakoglobin Canis lupus familiaris (Dog) (Canis familiaris) SCATTAMR 4.380000114 0.189640059 897.8648488 13.62834 14.88439 14.79885 0 16.07713 A0A8C0MSJ2 A0A8C0MSJ2_CANLF Plakophilin 4 PKP4 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609] STGSLGNSR 14.47999954 0.292549391 879.2679486 18.50484 17.64124 16.93739 17.26106 15.756 A0A8C0PFA2 A0A8C0PFA2_CANLF Pleckstrin and Sec7 domain containing 3 PSD3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of ARF protein signal transduction [GO:0032012] ruffle membrane [GO:0032587] guanyl-nucleotide exchange factor activity [GO:0005085] ESHPRCQLK 6.050000191 0.034144374 1153.681529 13.77055 0 14.78846 11.63935 13.13047 A0A8C0TI68 A0A8C0TI68_CANLF Pleckstrin and Sec7 domain containing PSD Canis lupus familiaris (Dog) (Canis familiaris) neuron projection development [GO:0031175]; regulation of ARF protein signal transduction [GO:0032012] "cleavage furrow [GO:0032154]; dendritic spine [GO:0043197]; postsynaptic density, intracellular component [GO:0099092]; ruffle membrane [GO:0032587]" guanyl-nucleotide exchange factor activity [GO:0005085]; phospholipid binding [GO:0005543] KADVAR 1.639999986 0.285526507 658.986889 13.94104 0 15.85829 15.79603 15.12346 A0A8C0LS98 A0A8C0LS98_CANLF Pleckstrin homology and RhoGEF domain containing G2 Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] ASANAPRR 8.609999657 0.094756883 843.2924917 17.6417 16.9475 14.87279 16.31993 16.65163 A0A8C0Z3B5 A0A8C0Z3B5_CANLF Pleckstrin homology domain containing A5 PLEKHA5 Canis lupus familiaris (Dog) (Canis familiaris) reproductive system development [GO:0061458] cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069] "phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]" DNPFRTTQPR 6.920000076 2.49E-13 1231.877022 0 0 14.44625 14.38161 13.91907 A0A8I3PVN0 A0A8I3PVN0_CANLF Pleckstrin homology like domain family B member 2 PHLDB2 Canis lupus familiaris (Dog) (Canis familiaris) "cell migration [GO:0016477]; establishment of cell polarity [GO:0030010]; establishment of protein localization [GO:0045184]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of wound healing, spreading of epidermal cells [GO:1903690]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gastrulation [GO:0010470]; regulation of microtubule cytoskeleton organization [GO:0070507]" basal cortex [GO:0045180]; cell leading edge [GO:0031252]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; intermediate filament cytoskeleton [GO:0045111]; plasma membrane [GO:0005886] IEEMER 12.97999954 0.294480002 806.8808879 14.95425 15.19848 19.65155 15.15509 16.57621 A0A8P0TGU1 A0A8P0TGU1_CANLF Plectin PLEC Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament cytoskeleton organization [GO:0045104] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] actin binding [GO:0003779] MAAAGTRR 1.710000038 0.117349794 849.7255901 13.56948 16.07564 0 16.24942 15.66429 A0A8C0PKW2 A0A8C0PKW2_CANLF Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-) PARP11 Canis lupus familiaris (Dog) (Canis familiaris) nuclear envelope organization [GO:0006998]; protein auto-ADP-ribosylation [GO:0070213] cytosol [GO:0005829]; nuclear body [GO:0016604]; nuclear envelope [GO:0005635] NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404] GTYFAR 2.369999886 0.174404509 713.3295824 16.36251 8.879717 16.69279 14.66937 15.34571 A0A8C0QNC0 A0A8C0QNC0_CANLF Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-) PARP8 Canis lupus familiaris (Dog) (Canis familiaris) NAD+ ADP-ribosyltransferase activity [GO:0003950] SCSGDPR 6.460000038 0 779.410355 14.96478 16.38455 0 0 16.64556 A0A8I3PPE9 A0A8I3PPE9_CANLF Poly(ADP-ribose) polymerase family member 9 PARP9 Canis lupus familiaris (Dog) (Canis familiaris) DNA damage checkpoint signaling [GO:0000077]; double-strand break repair [GO:0006302]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of type II interferon-mediated signaling pathway [GO:0060335]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; post-transcriptional regulation of gene expression [GO:0010608] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; site of DNA damage [GO:0090734] ADP-D-ribose binding [GO:0072570]; enzyme inhibitor activity [GO:0004857]; histone binding [GO:0042393]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity [GO:0140802]; STAT family protein binding [GO:0097677]; transcription corepressor activity [GO:0003714]; ubiquitin-like protein ligase binding [GO:0044389] AGLGHPHEQR 5.289999962 0.139362734 1100.453907 16.26142 11.44663 12.70624 13.99758 14.62758 A0A8C0MBI8 A0A8C0MBI8_CANLF Polybromo 1 PBRM1 Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338] RSC-type complex [GO:0016586] chromatin binding [GO:0003682]; DNA binding [GO:0003677] EPSPLLEKK 6.139999866 0.342830371 1041.336949 14.68569 16.77579 15.32626 16.40389 15.4694 A0A8C0RUQ4 A0A8C0RUQ4_CANLF "Polycystin 1, transient receptor potential channel interacting" PKD1 Canis lupus familiaris (Dog) (Canis familiaris) kidney development [GO:0001822] cilium [GO:0005929]; membrane [GO:0016020] LSANRPPR 2.559999943 0.313529968 909.7584992 16.72143 13.66772 14.76927 15.53099 15.08584 A0A8C0MQI7 A0A8C0MQI7_CANLF "Polyunsaturated fatty acid lipoxygenase ALOX15 (EC 1.13.11.12) (EC 1.13.11.31) (EC 1.13.11.33) (12/15-lipoxygenase) (Arachidonate 12-lipoxygenase, leukocyte-type) (Arachidonate 15-lipoxygenase) (Arachidonate omega-6 lipoxygenase) (Hepoxilin A3 synthase Alox15) (Linoleate 13S-lipoxygenase)" ALOX15 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic cell clearance [GO:0043277]; arachidonic acid metabolic process [GO:0019369]; bone mineralization [GO:0030282]; lipid oxidation [GO:0034440]; lipoxin A4 biosynthetic process [GO:2001303]; lipoxygenase pathway [GO:0019372]; negative regulation of adaptive immune response [GO:0002820]; phosphatidylethanolamine biosynthetic process [GO:0006646]; positive regulation of actin filament polymerization [GO:0030838]; regulation of engulfment of apoptotic cell [GO:1901074]; regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035358]; response to endoplasmic reticulum stress [GO:0034976]; wound healing [GO:0042060] cytosol [GO:0005829]; lipid droplet [GO:0005811]; plasma membrane [GO:0005886] arachidonate 12(S)-lipoxygenase activity [GO:0004052]; arachidonate 15-lipoxygenase activity [GO:0050473]; iron ion binding [GO:0005506]; lipid binding [GO:0008289] LQPDGK 12.13000011 0.108529943 657.5330354 13.19195 15.10872 14.9846 14.16568 15.34718 A0A8C0M7R4 A0A8C0M7R4_CANLF Potassium channel domain-containing protein KCNK2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] potassium channel activity [GO:0005267] EEVGEFR 2.380000114 0.325846996 865.0725904 16.93361 14.95665 16.72013 18.0854 15.01366 A0A8C0SUP1 A0A8C0SUP1_CANLF Potassium channel tetramerization domain containing 19 KCTD19 Canis lupus familiaris (Dog) (Canis familiaris) male meiotic nuclear division [GO:0007140]; protein homooligomerization [GO:0051260] nucleus [GO:0005634] EWDMVNCK 5.809999943 0.231273754 1097.028201 12.40956 12.9774 12.29568 15.8617 13.63515 A0A8C0P7N1 A0A8C0P7N1_CANLF Potassium inwardly rectifying channel subfamily J member 8 KCNJ8 Canis lupus familiaris (Dog) (Canis familiaris) "adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; atrioventricular node cell differentiation [GO:0060922]; calcium ion transmembrane transport [GO:0070588]; CAMKK-AMPK signaling cascade [GO:0061762]; coronary vasculature development [GO:0060976]; defense response to virus [GO:0051607]; determination of adult lifespan [GO:0008340]; establishment of cell polarity [GO:0030010]; fat cell differentiation [GO:0045444]; fatty acid transport [GO:0015908]; fibroblast proliferation [GO:0048144]; gene expression [GO:0010467]; glutamate secretion, neurotransmission [GO:0061535]; heart morphogenesis [GO:0003007]; microglial cell activation [GO:0001774]; neuromuscular process [GO:0050905]; NLRP3 inflammasome complex assembly [GO:0044546]; p38MAPK cascade [GO:0038066]; potassium ion import across plasma membrane [GO:1990573]; protein secretion [GO:0009306]; reactive gliosis [GO:0150103]; regulation of blood pressure [GO:0008217]; regulation of heart rate [GO:0002027]; response to ATP [GO:0033198]; response to cytokine [GO:0034097]; response to endoplasmic reticulum stress [GO:0034976]; response to exogenous dsRNA [GO:0043330]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to ischemia [GO:0002931]; response to lipopolysaccharide [GO:0032496]; response to resveratrol [GO:1904638]; response to xenobiotic stimulus [GO:0009410]; synaptic assembly at neuromuscular junction [GO:0051124]; transmission of nerve impulse [GO:0019226]; vasodilation [GO:0042311]; ventricular cardiac muscle tissue development [GO:0003229]" monoatomic ion channel complex [GO:0034702]; myofibril [GO:0030016]; presynapse [GO:0098793] ATP-activated inward rectifier potassium channel activity [GO:0015272]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1902282] AETLIFSR 3.710000038 0.3487727 937.0231997 16.23701 15.30362 17.13226 16.14011 15.38489 A0A8C0LW96 A0A8C0LW96_CANLF Potassium voltage-gated channel modifier subfamily G member 4 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] voltage-gated potassium channel complex [GO:0008076] voltage-gated potassium channel activity [GO:0005249] ILYVMR 16.5 0.070337859 809.4753357 17.14904 15.69938 16.92348 16.91438 16.53285 A0A8C0RS07 A0A8C0RS07_CANLF Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) KCNB1 Canis lupus familiaris (Dog) (Canis familiaris) action potential [GO:0001508]; cellular response to glucose stimulus [GO:0071333]; exocytosis [GO:0006887]; negative regulation of insulin secretion [GO:0046676]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of protein targeting to membrane [GO:0090314]; protein homooligomerization [GO:0051260]; regulation of action potential [GO:0098900] axon [GO:0030424]; dendrite [GO:0030425]; lateral plasma membrane [GO:0016328]; neuronal cell body membrane [GO:0032809]; perikaryon [GO:0043204]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251]; transmembrane transporter binding [GO:0044325] TNNPLK 8.520000458 0.031692265 685.2465933 15.11108 13.50234 14.02671 13.70695 14.87558 A0A8C0NE45 A0A8C0NE45_CANLF Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2) KCND2 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] anchoring junction [GO:0070161]; dendritic spine [GO:0043197]; perikaryon [GO:0043204]; postsynaptic membrane [GO:0045211]; voltage-gated potassium channel complex [GO:0008076] voltage-gated potassium channel activity [GO:0005249] HSQGLR 4.329999924 0.438524369 695.7407886 15.18963 15.87787 15.44406 0 15.14981 A0A8C0NSI2 A0A8C0NSI2_CANLF Pre-mRNA processing factor 40 homolog B PRPF40B Canis lupus familiaris (Dog) (Canis familiaris) "mRNA cis splicing, via spliceosome [GO:0045292]" EAAFRSMLR 4.599999905 0.052576465 1080.850553 16.6081 14.67544 15.64641 15.02127 15.77271 A0A8C0PE07 A0A8C0PE07_CANLF Pre-mRNA-processing factor 6 (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) PRPF6 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944]; RNA localization [GO:0006403]; spliceosomal tri-snRNP complex assembly [GO:0000244] catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682] identical protein binding [GO:0042802]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723] NTLMDMR 7.800000191 2.46E-13 895.1982687 12.74918 6.619647 16.55898 14.80189 14.62242 A0A8C0TD93 A0A8C0TD93_CANLF Prefoldin subunit 3 VBP1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of amyloid fibril formation [GO:1905907]; protein folding [GO:0006457] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; prefoldin complex [GO:0016272] amyloid-beta binding [GO:0001540]; unfolded protein binding [GO:0051082] LDEQYQK 14.68000031 0.24441042 924.0646208 14.13059 12.86993 13.99678 14.27176 15.16674 A0A8C0M5K9 A0A8C0M5K9_CANLF Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY Canis lupus familiaris (Dog) (Canis familiaris) gibberellic acid mediated signaling pathway [GO:0009740] SKLGITQQR 1.899999976 0.064018663 1030.939412 16.83027 14.40878 13.19786 13.7365 0 A0A8I3RPS3 A0A8I3RPS3_CANLF Proheparin-binding EGF-like growth factor HBEGF Canis lupus familiaris (Dog) (Canis familiaris) "cell chemotaxis [GO:0060326]; ERBB2-EGFR signaling pathway [GO:0038134]; ERBB2-ERBB4 signaling pathway [GO:0038135]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of wound healing [GO:0090303]; regulation of heart contraction [GO:0008016]; wound healing, spreading of epidermal cells [GO:0035313]" cell surface [GO:0009986]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] epidermal growth factor receptor binding [GO:0005154]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297] LLRSVVLK 10.25 0.32164469 927.4720077 17.5241 15.07927 15.16444 16.11686 15.37612 A0A8C0NDX2 A0A8C0NDX2_CANLF Proline rich 23A LOC611145 Canis lupus familiaris (Dog) (Canis familiaris) APGPGPK 3.400000095 0.262964241 624.3459398 16.66804 17.56693 16.61719 16.89775 14.95676 A0A8C0N4C7 A0A8C0N4C7_CANLF Prolyl endopeptidase (EC 3.4.21.-) PREP Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] MTELYDYPK 3.700000048 0.190607154 1158.893812 11.56338 15.21644 16.6526 13.57684 14.35261 A0A8C0MKC7 A0A8C0MKC7_CANLF "Propionyl-CoA carboxylase alpha chain, mitochondrial (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha)" PCCA Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042] catalytic complex [GO:1902494]; mitochondrial matrix [GO:0005759] ATP binding [GO:0005524]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; propionyl-CoA carboxylase activity [GO:0004658] DADEAVR 3.450000048 1.23E-13 774.3208667 0 16.09282 13.80704 14.4768 13.96231 A0A8I3MQM8 A0A8I3MQM8_CANLF Prosaposin PSAP Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; ganglioside GM1 transport to membrane [GO:1905572]; lysosomal transport [GO:0007041]; regulation of lipid metabolic process [GO:0019216]; sphingolipid metabolic process [GO:0006665] extracellular space [GO:0005615]; late endosome [GO:0005770]; lysosome [GO:0005764] ganglioside GM1 binding [GO:1905573]; ganglioside GM2 binding [GO:1905574]; ganglioside GM3 binding [GO:1905575]; ganglioside GP1c binding [GO:1905577]; ganglioside GT1b binding [GO:1905576]; phospholipid binding [GO:0005543]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; scaffold protein binding [GO:0097110] LPSSLSK 5.789999962 0.003207029 730.3281843 13.68056 14.9381 15.22402 14.7765 15.44734 A0A8C0SP10 A0A8C0SP10_CANLF Proteasomal ATPase associated factor 1 PAAF1 Canis lupus familiaris (Dog) (Canis familiaris) proteasome complex [GO:0000502] KSIHISCPK 2.069999933 0.177745831 1069.116711 0 13.26664 14.46467 14.94942 15.1364 A0A8C0RLC9 A0A8C0RLC9_CANLF Protein LIAT1 Canis lupus familiaris (Dog) (Canis familiaris) non-membrane-bounded organelle assembly [GO:0140694] nucleolus [GO:0005730] molecular condensate scaffold activity [GO:0140693] HQSRGLK 4.21999979 0.305892434 825.712479 13.91797 13.84676 15.86742 16.7729 16.70618 A0A8C0SYF8 A0A8C0SYF8_CANLF Protein O-mannose kinase (EC 2.7.1.183) (Protein kinase-like protein SgK196) (Sugen kinase 196) POMK Canis lupus familiaris (Dog) (Canis familiaris) protein O-linked glycosylation [GO:0006493] endoplasmic reticulum membrane [GO:0005789] ATP binding [GO:0005524]; carbohydrate kinase activity [GO:0019200]; protein kinase activity [GO:0004672] LTSLEMK 5.010000229 1.23E-13 836.912003 16.04807 13.41972 13.3972 0 13.81257 A0A8C0PAF4 A0A8C0PAF4_CANLF Protein SPT2 homolog SPTY2D1 Canis lupus familiaris (Dog) (Canis familiaris) heterochromatin formation [GO:0031507]; nucleosome assembly [GO:0006334]; regulation of DNA-templated transcription [GO:0006355] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; histone binding [GO:0042393]; histone chaperone activity [GO:0140713] EEEEMK 6.880000114 0.192142856 808.355123 15.52119 15.01587 17.2294 13.44755 0 A0A8C0QHW2 A0A8C0QHW2_CANLF Protein YIPF YIPF5 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; insulin processing [GO:0030070]; protein transport [GO:0015031]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628] COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654] TLTVLHPLK 3.25 0.024827823 1022.274683 13.73681 16.59301 14.34801 14.33724 12.54848 A0A8I3RYV6 A0A8I3RYV6_CANLF Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 72) PDIA4 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum lumen [GO:0005788]; melanosome [GO:0042470] protein disulfide isomerase activity [GO:0003756] SQPVPK 3.99000001 1.22E-13 655.6127726 9.087981 0 0 0 13.84086 A0A8C0Z2G3 A0A8C0Z2G3_CANLF Protein kinase domain-containing protein IKBKE Canis lupus familiaris (Dog) (Canis familiaris) cellular response to virus [GO:0098586]; gene expression [GO:0010467]; interleukin-17-mediated signaling pathway [GO:0097400]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mRNA stabilization [GO:0048255]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of lipid storage [GO:0010884]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; regulation of protein-containing complex assembly [GO:0043254]; response to interferon-beta [GO:0035456]; response to type I interferon [GO:0034340] mitochondrial membrane [GO:0031966]; PML body [GO:0016605] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; IkappaB kinase activity [GO:0008384]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; ubiquitin protein ligase binding [GO:0031625] ASETPK 5.380000114 0.287811241 633.2755252 15.94153 18.46363 17.86795 20.62036 18.66711 A0A8C0PBM0 A0A8C0PBM0_CANLF Protein kinase domain-containing protein NEK10 Canis lupus familiaris (Dog) (Canis familiaris) phosphorylation [GO:0016310] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] LILPNK 20.97999954 0.344287467 696.5605825 19.88852 17.46066 16.96597 17.20031 16.32845 A0A8C0QCL9 A0A8C0QCL9_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] MGTDRGSP 5.769999981 0.270142985 837.4200002 14.25295 13.19429 0 14.89622 14.38208 A0A8C0P0H3 A0A8C0P0H3_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) phosphorylation [GO:0016310] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] LIDFGCAK 14.65999985 0.253076799 922.8431917 15.04516 15.22537 17.26703 16.41121 16.08141 A0A8C0P4T7 A0A8C0P4T7_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] HTKTVETLLK 4.71999979 0.021665279 1169.747792 16.56819 13.10581 11.06781 13.58577 12.67739 A0A8C0N340 A0A8C0N340_CANLF Protein lin-54 homolog LIN54 Canis lupus familiaris (Dog) (Canis familiaris) nucleosome organization [GO:0034728] RNA polymerase II transcription repressor complex [GO:0090571] minor groove of adenine-thymine-rich DNA binding [GO:0003680]; transcription regulatory region nucleic acid binding [GO:0001067] VSQTSDLK 4.139999866 0.296355239 876.8957189 13.56913 14.53461 14.32909 15.57091 16.42076 A0A8I3MWF8 A0A8I3MWF8_CANLF Protein naked cuticle homolog NKD1 Canis lupus familiaris (Dog) (Canis familiaris) "axis elongation [GO:0003401]; convergent extension [GO:0060026]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; Wnt signaling pathway [GO:0016055]" cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; protein phosphatase type 2A complex [GO:0000159] calcium ion binding [GO:0005509]; PDZ domain binding [GO:0030165] ELVGEVFR 5.820000172 0.20852757 949.0197178 17.7394 18.863 19.15835 21.55305 18.39716 A0A8I3NLG2 A0A8I3NLG2_CANLF Protein phosphatase 1 regulatory subunit 9B PPP1R9B Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015]; calcium-mediated signaling [GO:0019722]; cell migration [GO:0016477]; cellular response to morphine [GO:0071315]; dendrite development [GO:0016358]; filopodium assembly [GO:0046847]; negative regulation of cell growth [GO:0030308]; regulation of opioid receptor signaling pathway [GO:2000474]; regulation of protein phosphorylation [GO:0001932] cortical actin cytoskeleton [GO:0030864]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; ruffle membrane [GO:0032587] EMMEQR 1.960000038 0.154367415 822.8641596 17.20753 18.24 0 17.7117 0 A0A8P0NSQ4 A0A8P0NSQ4_CANLF Protein phosphatase 2 scaffold subunit Abeta PPP2R1B Canis lupus familiaris (Dog) (Canis familiaris) GRAAATSLR 1.549999952 0.224015635 903.006698 13.32821 0 15.02855 14.17227 15.82088 A0A8C0T6U4 A0A8C0T6U4_CANLF Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.-) Canis lupus familiaris (Dog) (Canis familiaris) protein methylesterase activity [GO:0051723] DLTIGQMQGK 10.61999989 0.296701852 1106.148408 15.06242 17.73949 19.48793 17.30669 16.76895 A0A8C0MHX9 A0A8C0MHX9_CANLF "Protein phosphatase, Mg2+/Mn2+ dependent 1E" PPM1E Canis lupus familiaris (Dog) (Canis familiaris) cellular response to lipopolysaccharide [GO:0071222]; cellular response to xenobiotic stimulus [GO:0071466]; positive regulation of stress fiber assembly [GO:0051496] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991] metal ion binding [GO:0046872]; protein serine/threonine phosphatase activity [GO:0004722] ENNGDSSMVAHK 14.77999973 0.588111506 1302.969437 17.58477 15.98008 17.04234 14.88309 16.87906 A0A8C0SDE6 A0A8C0SDE6_CANLF Protein sprouty homolog 1 SPRY1 Canis lupus familiaris (Dog) (Canis familiaris) bud elongation involved in lung branching [GO:0060449]; ERK1 and ERK2 cascade [GO:0070371]; establishment of mitotic spindle orientation [GO:0000132]; metanephros development [GO:0001656]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of lens fiber cell differentiation [GO:1902747]; negative regulation of neurotrophin TRK receptor signaling pathway [GO:0051387]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; organ induction [GO:0001759]; ureteric bud development [GO:0001657] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654] GQGKPS 2.019999981 0.061790459 573.3164587 16.12549 15.6533 0 13.68594 15.37202 A0A8C0Q899 A0A8C0Q899_CANLF Protein-arginine deiminase (EC 3.5.3.15) PADI2 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to leukemia inhibitory factor [GO:1990830]; intracellular estrogen receptor signaling pathway [GO:0030520]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of lymphocyte chemotaxis [GO:1901624]; transcription initiation-coupled chromatin remodeling [GO:0045815] cytoplasm [GO:0005737]; euchromatin [GO:0000791] calcium ion binding [GO:0005509]; histone H3R26 arginine deiminase activity [GO:0140798]; nuclear estrogen receptor binding [GO:0030331]; protein homodimerization activity [GO:0042803] GLGGMSSK 11.19999981 0.004139615 736.511792 14.71793 16.76961 15.53888 14.60952 15.82517 A0A8C0MY03 A0A8C0MY03_CANLF Protein-tyrosine-phosphatase DUSP21 Canis lupus familiaris (Dog) (Canis familiaris) dephosphorylation [GO:0016311] mitochondrial inner membrane [GO:0005743]; nucleus [GO:0005634] MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; protein tyrosine phosphatase activity [GO:0004725] MTTPPCLLPAQAVR 4.449999809 0.412139436 1571.343403 16.58696 0 14.73771 17.92687 17.36447 A0A8C0SCB1 A0A8C0SCB1_CANLF Proteolipid protein 2 LOC480914 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] MADSER 6.03000021 0.316886771 707.5590262 15.87492 15.04233 17.02479 16.18577 16.31524 A0A8C0P0S1 A0A8C0P0S1_CANLF Protrudin (Zinc finger FYVE domain-containing protein 27) ZFYVE27 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum tubular network formation [GO:0071787]; protein localization to plasma membrane [GO:0072659]; vesicle-mediated transport [GO:0016192] endoplasmic reticulum membrane [GO:0005789]; growth cone membrane [GO:0032584]; recycling endosome membrane [GO:0055038] metal ion binding [GO:0046872] VVSEYR 3.039999962 0.317489581 751.6676311 0 15.19475 16.84124 14.85785 15.82201 A0A8C0MKY2 A0A8C0MKY2_CANLF Pseudouridine synthase RsuA/RluA-like domain-containing protein RPUSD3 Canis lupus familiaris (Dog) (Canis familiaris) pseudouridine synthesis [GO:0001522] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723] RTVPAAEMGGCR 6.639999866 2.43E-13 1320.639225 0 12.39367 11.48876 0 7.954705 A0A8C0PVW9 A0A8C0PVW9_CANLF Pyridoxal dependent decarboxylase domain containing 1 PDXDC1 Canis lupus familiaris (Dog) (Canis familiaris) carboxylic acid metabolic process [GO:0019752] carbon-carbon lyase activity [GO:0016830]; pyridoxal phosphate binding [GO:0030170] IHAGLLKK 2.089999914 0.064416827 879.47689 16.47679 14.88453 14.56866 15.08827 13.96376 A0A8C0N145 A0A8C0N145_CANLF Pyridoxal phosphatase PDXP Canis lupus familiaris (Dog) (Canis familiaris) actin rod assembly [GO:0031247]; cellular response to ATP [GO:0071318]; dephosphorylation [GO:0016311]; positive regulation of actin filament depolymerization [GO:0030836]; pyridoxal phosphate catabolic process [GO:0032361]; regulation of cytokinesis [GO:0032465]; regulation of mitotic nuclear division [GO:0007088] actin cytoskeleton [GO:0015629]; cell-cell junction [GO:0005911]; cleavage furrow [GO:0032154]; contractile ring [GO:0070938]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; midbody [GO:0030496]; ruffle membrane [GO:0032587] heat shock protein binding [GO:0031072]; magnesium ion binding [GO:0000287]; phosphoprotein phosphatase activity [GO:0004721]; protein homodimerization activity [GO:0042803]; pyridoxal phosphatase activity [GO:0033883] FARLGFGGLR 4.349999905 0.273919752 1094.618119 17.35554 16.05305 16.20794 19.56939 18.94693 A0A8C0P572 A0A8C0P572_CANLF R3H domain and coiled-coil containing 1 like R3HCC1L Canis lupus familiaris (Dog) (Canis familiaris) MTMGSK 3.150000095 0.180263611 671.3284371 13.72146 15.52242 13.72734 14.08368 15.44575 A0A8C0MAA5 A0A8C0MAA5_CANLF "RAB31, member RAS oncogene family" RAB31 Canis lupus familiaris (Dog) (Canis familiaris) endosome [GO:0005768]; membrane [GO:0016020] GTP binding [GO:0005525]; GTPase activity [GO:0003924] SSIVCR 4.199999809 0 721.4187469 15.70949 13.80685 14.6438 14.92513 14.91716 A0A8C0MMC2 A0A8C0MMC2_CANLF RAMA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EILAVPNKFSESGK 5.090000153 2.46E-13 1519.626618 15.80539 14.75572 15.14392 0 14.01895 A0A8C0PFM2 A0A8C0PFM2_CANLF RB1 inducible coiled-coil 1 RB1CC1 Canis lupus familiaris (Dog) (Canis familiaris) autophagosome assembly [GO:0000045]; extrinsic apoptotic signaling pathway [GO:0097191]; heart development [GO:0007507]; liver development [GO:0001889]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive regulation of autophagy [GO:0010508]; positive regulation of cell size [GO:0045793]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein phosphorylation [GO:0001934]; regulation of protein lipidation [GO:1903059]; reticulophagy [GO:0061709] Atg1/ULK1 kinase complex [GO:1990316]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; lysosome [GO:0005764]; nuclear membrane [GO:0031965]; phagophore assembly site membrane [GO:0034045] protein kinase binding [GO:0019901] VSDLSDMR 4.739999771 0.314952301 939.1978504 13.9013 0 16.26306 14.45465 14.82709 A0A8I3MK51 A0A8I3MK51_CANLF RCSD domain containing 1 RCSD1 Canis lupus familiaris (Dog) (Canis familiaris) QERSEPSAK 7.309999943 0.333763944 1030.10764 14.05688 13.55118 14.32042 13.51346 14.70784 A0A8I3RSS9 A0A8I3RSS9_CANLF RD3 regulator of GUCY2D RD3 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601] cone photoreceptor outer segment [GO:0120199]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor inner segment [GO:0001917]; rod photoreceptor outer segment [GO:0120200] APALDPR 14.96000004 0.186806198 738.0504258 19.9241 20.37336 19.62382 22.88673 20.99812 A0A8C0P6I5 A0A8C0P6I5_CANLF RIMS binding protein 2 RIMBP2 Canis lupus familiaris (Dog) (Canis familiaris) AWQPDKVK 3.869999886 0.256670128 970.6651906 17.90684 17.34745 18.57721 17.8804 19.57085 A0A8C0QGP9 A0A8C0QGP9_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) TRIM17 Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087]; negative regulation of AIM2 inflammasome complex assembly [GO:0140972]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neurogenesis [GO:0050768]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral transcription [GO:0032897]; positive regulation of viral entry into host cell [GO:0046598]; protein autoubiquitination [GO:0051865]; suppression of viral release by host [GO:0044790] cytosol [GO:0005829]; nucleoplasm [GO:0005654] protein domain specific binding [GO:0019904]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] AHQELLK 5.079999924 0.25777771 837.8020028 18.10385 18.84642 0 19.91432 18.07063 A0A8C0P6X9 A0A8C0P6X9_CANLF RLF zinc finger RLF Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] VTHKLLDNEK 6.739999771 0.16475078 1197.517017 16.96911 15.97588 0 12.59993 15.86417 A0A8P0PN05 A0A8P0PN05_CANLF RNA binding motif protein 38 RBM38 Canis lupus familiaris (Dog) (Canis familiaris) GRPALPHHR 6.300000191 0.106164307 1041.183283 15.01913 14.04982 15.65394 14.70615 14.14636 A0A8C0PLF7 A0A8C0PLF7_CANLF RNA exonuclease 5 REXO5 Canis lupus familiaris (Dog) (Canis familiaris) exonuclease activity [GO:0004527]; RNA binding [GO:0003723] DLKSGK 1.460000038 0.387613875 645.7983347 0 0 16.99866 14.09352 14.93671 A0A8C0MJL0 A0A8C0MJL0_CANLF RNA helicase (EC 3.6.4.13) DDX56 Canis lupus familiaris (Dog) (Canis familiaris) defense response to virus [GO:0051607]; modulation by host of viral RNA genome replication [GO:0044830]; negative regulation of type I interferon production [GO:0032480] cytosol [GO:0005829]; nucleolus [GO:0005730] ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; protein sequestering activity [GO:0140311]; RNA helicase activity [GO:0003724]; RNA stem-loop binding [GO:0035613] WAEPAQLR 2.730000019 0.072071444 969.6541819 15.34213 15.99087 17.90966 15.06353 15.19194 A0A8C0Z6E1 A0A8C0Z6E1_CANLF RNA helicase (EC 3.6.4.13) Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA nuclease activity [GO:0004540] GEILSK 10.28999996 0 646.2230441 18.05586 0 16.60312 0 16.77386 A0A8P0TIW3 A0A8P0TIW3_CANLF RNA polymerase I subunit E POLR1E Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351] DNA-directed RNA polymerase complex [GO:0000428]; nucleolus [GO:0005730] DNA binding [GO:0003677] NLPNIP 8.380000114 0 667.2152449 16.3378 0 14.39173 0 0 A0A8I3MS03 A0A8I3MS03_CANLF RNA polymerase II subunit C POLR2C Canis lupus familiaris (Dog) (Canis familiaris) transcription by RNA polymerase II [GO:0006366] "cytosol [GO:0005829]; RNA polymerase II, core complex [GO:0005665]" DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; protein dimerization activity [GO:0046983] MPYANQPTVR 4.800000191 0.075931964 1175.976603 20.09907 0 0 12.87973 15.35505 A0A8C0PL51 A0A8C0PL51_CANLF RNA uridylyltransferase (EC 2.7.7.52) TUT7 Canis lupus familiaris (Dog) (Canis familiaris) miRNA metabolic process [GO:0010586]; mRNA catabolic process [GO:0006402]; mRNA destabilization [GO:0061157]; pre-miRNA processing [GO:0031054]; retrotransposon silencing by mRNA destabilization [GO:0141008]; RNA 3' uridylation [GO:0071076] cytosol [GO:0005829]; nucleoplasm [GO:0005654] miRNA binding [GO:0035198]; RNA uridylyltransferase activity [GO:0050265]; zinc ion binding [GO:0008270] HDSGTQAK 9.609999657 0.32989804 842.9810794 18.9567 20.20702 13.51511 0 17.59196 A0A8P0P6N2 A0A8P0P6N2_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) EIQIKTTM 8.739999771 0.258058971 964.2725612 14.99642 16.90065 14.92034 15.35159 16.06063 A0A8C0P5R2 A0A8C0P5R2_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] AKDMNR 4.809999943 0.115504885 735.2616294 18.71708 13.99796 15.75336 16.15896 17.19886 A0A8C0P0H8 A0A8C0P0H8_CANLF RRM domain-containing protein ENOX1 Canis lupus familiaris (Dog) (Canis familiaris) ultradian rhythm [GO:0007624] external side of plasma membrane [GO:0009897] oxidoreductase activity [GO:0016491]; RNA binding [GO:0003723] AWDHFSK 3.579999924 0 889.9253542 15.31197 15.13794 15.68435 15.75188 12.11814 A0A8C0PBK6 A0A8C0PBK6_CANLF RRM domain-containing protein LOC119868769 Canis lupus familiaris (Dog) (Canis familiaris) ribonucleoprotein complex [GO:1990904] RNA binding [GO:0003723] GFPLSMER 9 0.242580098 936.6681218 16.64332 13.83569 16.25551 15.12955 14.41832 A0A8C0M9S0 A0A8C0M9S0_CANLF RRM domain-containing protein TRA2A Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] ESRSQSK 4.099999905 1.22E-13 821.2049042 14.81364 14.43284 15.00121 15.92327 14.945 A0A8C0PCA5 A0A8C0PCA5_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mRNA 3'-end processing [GO:0031124] nucleus [GO:0005634] RNA binding [GO:0003723] VWEPRR 2.819999933 0 842.9174845 9.387936 0 11.26814 13.67765 0 A0A8C0NGQ3 A0A8C0NGQ3_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] GSAPGELGR 4.489999771 0.375981011 842.9218165 18.5266 16.55233 16.92585 17.26931 16.59547 A0A8I3NGV6 A0A8I3NGV6_CANLF RUN and FYVE domain containing 3 RUFY3 Canis lupus familiaris (Dog) (Canis familiaris) CLLISTK 14.23999977 0 834.9090274 20.28723 21.82302 0 23.35391 21.7441 A0A8C0RHW1 A0A8C0RHW1_CANLF RUN and SH3 domain containing 2 RUSC2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic vesicle [GO:0031410] small GTPase binding [GO:0031267] GPGAPK 4.130000114 0.026175853 526.463458 0 0 15.51583 15.9526 16.55375 A0A8I3P5H6 A0A8I3P5H6_CANLF Rab interacting lysosomal protein like 2 RILPL2 Canis lupus familiaris (Dog) (Canis familiaris) epithelial cell morphogenesis [GO:0003382]; protein transport from ciliary membrane to plasma membrane [GO:1903445] centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]; membrane [GO:0016020] identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983] ITCGWPL 7.079999924 0.240380729 848.0662025 12.44549 14.6456 14.70033 15.37421 14.93264 A0A8C0ML05 A0A8C0ML05_CANLF Ral transcription factor IIIC subunit 2 GTF3C2 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654]; transcription factor TFIIIC complex [GO:0000127] DNA binding [GO:0003677]; RNA polymerase III general transcription initiation factor activity [GO:0000995] ASKPGRK 4.809999943 0.223814755 742.7860982 17.43456 14.67223 15.49509 14.42359 15.88471 A0A8C0T0T6 A0A8C0T0T6_CANLF Ran-binding protein 9 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] LAPARPARR 4.46999979 0.313443727 1008.613946 13.94643 14.41567 16.29539 15.67625 15.68017 A0A8C0T4T0 A0A8C0T4T0_CANLF RanBP2-type domain-containing protein NUP153 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of RNA export from nucleus [GO:0046832]; nuclear pore complex assembly [GO:0051292] cytosol [GO:0005829]; nuclear inclusion body [GO:0042405]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore nuclear basket [GO:0044615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-membrane adaptor activity [GO:0043495]; structural constituent of nuclear pore [GO:0017056] FSSPIVK 2.329999924 0.023795632 778.4646856 14.75488 14.38335 14.73011 14.39578 16.82636 A0A8C0N517 A0A8C0N517_CANLF Rap associating with DIL domain LOC479761 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] membrane [GO:0016020] SDVETAKK 13.89999962 0.091483757 878.3132483 15.09105 14.34824 15.60646 13.89286 15.29317 A0A8C0MZY7 A0A8C0MZY7_CANLF Rap-GAP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of small GTPase mediated signal transduction [GO:0051056] GTPase activator activity [GO:0005096] LSHASSSAGH 5.980000019 0.29173408 953.8889201 17.49487 14.93684 13.05225 14.94262 15.40372 A0A8C0NWA3 A0A8C0NWA3_CANLF Ras homolog family member D RHOD Canis lupus familiaris (Dog) (Canis familiaris) small GTPase mediated signal transduction [GO:0007264] GTP binding [GO:0005525]; GTPase activity [GO:0003924] VVLVGDGGCGK 7.980000019 0.761854367 1060.704074 0 18.56465 0 0 0 A0A8C0M3Z1 A0A8C0M3Z1_CANLF Ras related dexamethasone induced 1 RASD1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529] GTP binding [GO:0005525]; GTPase activity [GO:0003924] MVILGSSK 12.80000019 0.246530763 849.6733972 20.70478 21.71382 19.32452 20.88193 20.04254 P24409 RAB10_CANLF Ras-related protein Rab-10 (EC 3.6.5.2) RAB10 Canis lupus familiaris (Dog) (Canis familiaris) axonogenesis [GO:0007409]; cellular response to insulin stimulus [GO:0032869]; endosomal transport [GO:0016197]; establishment of neuroblast polarity [GO:0045200]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi to plasma membrane transport [GO:0006893]; polarized epithelial cell differentiation [GO:0030859]; protein localization to basolateral plasma membrane [GO:1903361]; protein localization to plasma membrane [GO:0072659]; vesicle-mediated transport [GO:0016192] cilium [GO:0005929]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; insulin-responsive compartment [GO:0032593]; phagocytic vesicle membrane [GO:0030670]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802] G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; myosin V binding [GO:0031489] CDMDDKR 9.68999958 0.292709231 954.3874126 17.70415 12.81921 15.98941 18.77389 17.14126 A0A8I3NZA0 A0A8I3NZA0_CANLF Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) PTPRF Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; dephosphorylation [GO:0016311]; neuron projection regeneration [GO:0031102]; regulation of axon regeneration [GO:0048679]; synaptic membrane adhesion [GO:0099560] neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] cell adhesion molecule binding [GO:0050839]; chondroitin sulfate proteoglycan binding [GO:0035373]; protein tyrosine phosphatase activity [GO:0004725]; protein-containing complex binding [GO:0044877] TFALHKSGSSEK 1.379999995 0 1290.827947 13.79618 15.45108 0 15.5041 0 A0A8I3N1T2 A0A8I3N1T2_CANLF Recombination signal binding protein for immunoglobulin kappa J region RBPJ Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; aortic valve development [GO:0003176]; arterial endothelial cell fate commitment [GO:0060844]; atrioventricular canal development [GO:0036302]; auditory receptor cell fate commitment [GO:0009912]; B cell differentiation [GO:0030183]; blood vessel endothelial cell fate specification [GO:0097101]; blood vessel lumenization [GO:0072554]; blood vessel remodeling [GO:0001974]; cardiac left ventricle morphogenesis [GO:0003214]; cardiac muscle cell myoblast differentiation [GO:0060379]; club cell differentiation [GO:0060486]; defense response to bacterium [GO:0042742]; dorsal aorta morphogenesis [GO:0035912]; endocardium morphogenesis [GO:0003160]; epidermal cell fate specification [GO:0009957]; epithelial cell proliferation [GO:0050673]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; hair follicle maturation [GO:0048820]; humoral immune response [GO:0006959]; inflammatory response to antigenic stimulus [GO:0002437]; keratinocyte differentiation [GO:0030216]; labyrinthine layer blood vessel development [GO:0060716]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of ossification [GO:0030279]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract morphogenesis [GO:0003151]; pituitary gland development [GO:0021983]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell proliferation involved in heart morphogenesis [GO:2000138]; positive regulation of ephrin receptor signaling pathway [GO:1901189]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERBB signaling pathway [GO:1901186]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription of Notch receptor target [GO:0007221]; pulmonary valve development [GO:0003177]; regulation of cell adhesion involved in heart morphogenesis [GO:0061344]; regulation of generation of precursor metabolites and energy [GO:0043467]; regulation of reproductive process [GO:2000241]; regulation of timing of cell differentiation [GO:0048505]; sebaceous gland development [GO:0048733]; secondary heart field specification [GO:0003139]; somatic stem cell population maintenance [GO:0035019]; somitogenesis [GO:0001756]; stem cell proliferation [GO:0072089]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222] cytoplasm [GO:0005737]; MAML1-RBP-Jkappa- ICN1 complex [GO:0002193]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; transcription repressor complex [GO:0017053] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]" VISKPSK 5.360000134 0.154887663 757.6133507 16.60898 16.64469 17.37819 14.74008 16.11181 A0A8C0QBR7 A0A8C0QBR7_CANLF Regulator of G protein signaling 6 RGS6 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] GTPase activator activity [GO:0005096] TSLEKFTR 19.5 0.396185036 981.0606616 22.48123 17.83494 15.71884 16.06334 21.79332 A0A1C8YZ53 A0A1C8YZ53_COPV Regulatory protein E2 E2 Canine oral papillomavirus (COPV) DNA replication [GO:0006260]; DNA-templated transcription [GO:0006351]; regulation of DNA replication [GO:0006275]; viral DNA genome replication [GO:0039693] host cell nucleus [GO:0042025] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; nucleotide binding [GO:0000166] EDFMDR 4 0.345733193 828.7082719 16.08115 16.06056 18.43452 14.63163 15.23231 A0A8C0LTD0 A0A8C0LTD0_CANLF Reticulon RTN1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] SQALKGMLSK 1.610000014 0 1077.838164 0 11.23908 0 11.62981 0 A0A8I3NIH7 A0A8I3NIH7_CANLF Retinoic acid receptor RXR (Nuclear receptor subfamily 2 group B member) RXRA Canis lupus familiaris (Dog) (Canis familiaris) mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; positive regulation of thyroid hormone mediated signaling pathway [GO:0002157]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vitamin D receptor signaling pathway [GO:0070564]; response to retinoic acid [GO:0032526]; retinoic acid receptor signaling pathway [GO:0048384] chromatin [GO:0000785]; receptor complex [GO:0043235]; RNA polymerase II transcription regulator complex [GO:0090575] DNA binding domain binding [GO:0050692]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; LBD domain binding [GO:0050693]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; nuclear vitamin D receptor binding [GO:0042809]; peptide binding [GO:0042277]; retinoic acid binding [GO:0001972]; retinoic acid-responsive element binding [GO:0044323]; transcription coregulator binding [GO:0001221]; vitamin D response element binding [GO:0070644]; zinc ion binding [GO:0008270] RVQGLAGLR 10.10000038 0.292015557 970.5050291 17.78008 17.16604 16.82597 16.71371 17.72197 A0A8C0NET9 A0A8C0NET9_CANLF Rho GTPase activating protein 10 ARHGAP10 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737] GTPase activator activity [GO:0005096] NYSLIDK 1.149999976 0.2457381 852.4575332 12.95772 13.17001 11.20805 13.42484 14.60106 A0A8I3NMH6 A0A8I3NMH6_CANLF Rho GTPase activating protein 8 ARHGAP8 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of ERK1 and ERK2 cascade [GO:0070374]; signal transduction [GO:0007165] GTPase activator activity [GO:0005096] ASEPQNR 6.789999962 0.315513154 802.098657 17.57581 17.15694 16.91699 19.85034 17.35893 A0A8C0M1A2 A0A8C0M1A2_CANLF Rho GTPase-activating protein 26 (Rho-type GTPase-activating protein 26) ARHGAP26 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925] GTPase activator activity [GO:0005096] AAEGPGVPGRQGGR 4.679999828 0.504161286 1309.393985 17.1511 15.59299 0 16.50397 17.45628 A0A8C0N2T5 A0A8C0N2T5_CANLF Rho GTPase-activating protein 29 (Rho-type GTPase-activating protein 29) Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] metal ion binding [GO:0046872] ILIKSK 20.64999962 0.062560072 701.4840837 18.91496 18.84037 19.15892 18.79854 18.9218 A0A8C0MMD1 A0A8C0MMD1_CANLF Rho GTPase-activating protein 35 ARHGAP35 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; lipid binding [GO:0008289] TTKSSNTSSLT 2.400000095 0.022655325 1127.142146 8.055187 12.97599 12.1999 15.02541 11.28948 A0A8I3MXJ0 A0A8I3MXJ0_CANLF Rho guanine nucleotide exchange factor 28 ARHGEF28 Canis lupus familiaris (Dog) (Canis familiaris) central nervous system neuron axonogenesis [GO:0021955]; neurofilament cytoskeleton organization [GO:0060052] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872] ESLLHLAMR 4.389999866 0 1084.806744 0 13.22849 0 8.118195 0 A0A8C0MG67 A0A8C0MG67_CANLF Rho guanine nucleotide exchange factor 40 Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] AAAGAGGTVRR 5.659999847 0.276736325 986.0606179 13.86904 14.96837 13.00156 14.46903 14.44315 A0A8C0T6M5 A0A8C0T6M5_CANLF Rho guanine nucleotide exchange factor 9 (Collybistin) (Rac/Cdc42 guanine nucleotide exchange factor 9) ARHGEF9 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] guanyl-nucleotide exchange factor activity [GO:0005085] YTAQDHSDYR 1.649999976 0.032067541 1256.550124 12.78689 11.04262 14.1264 12.72475 12.13092 A0A8C0MH78 A0A8C0MH78_CANLF Rho-GAP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] LSGCTAK 4.599999905 0 735.2186211 17.42848 15.7173 0 16.51685 0 A0A8C0NPH4 A0A8C0NPH4_CANLF Rho-GAP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of Rho protein signal transduction [GO:0035023]; signal transduction [GO:0007165] GTPase activator activity [GO:0005096] DLNNKVK 6.239999771 0.333536378 830.7411112 13.19987 0 15.66372 13.96826 15.25231 A0A8C0MDE6 A0A8C0MDE6_CANLF Ribosomal RNA-processing protein 40 EXOSC3 Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] cytoplasm [GO:0005737]; exosome (RNase complex) [GO:0000178] RNA binding [GO:0003723] LNAGTRSR 5.099999905 0.564655444 874.6468746 9.164825 0 11.9769 11.18319 0 A0A8C0N7U1 A0A8C0N7U1_CANLF Ribosomal protein S6 kinase (EC 2.7.11.1) RPS6KA1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674] RDLDEGVLK 6.800000191 0.042624697 1044.524731 14.24363 13.79025 13.36341 15.48982 14.581 A0A8C0M2X3 A0A8C0M2X3_CANLF Ribosomal protein S6 kinase (EC 2.7.11.1) Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674] GDFSFEGEAWK 1.389999986 2.43E-13 1272.495172 8.106276 0 11.74819 11.63805 0 A0A8C0MGZ9 A0A8C0MGZ9_CANLF Ribosome production factor 2 homolog (Ribosome biogenesis protein RPF2 homolog) RPF2 Canis lupus familiaris (Dog) (Canis familiaris) maturation of LSU-rRNA [GO:0000470] nucleolus [GO:0005730] rRNA binding [GO:0019843] NLLIDFFR 28.54999924 0.669529453 1036.82656 19.06211 17.8715 19.18091 20.18297 20.29204 A0A8C0SQX8 A0A8C0SQX8_CANLF Ring finger protein 103 RNF103 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567]; ubiquitin-dependent ERAD pathway [GO:0030433] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] QSVVHNSPGR 9.960000038 0.23760037 1079.909159 16.26986 14.52643 14.01732 13.81074 12.35244 A0A8C0MGU7 A0A8C0MGU7_CANLF Ring finger protein 213 Canis lupus familiaris (Dog) (Canis familiaris) anatomical structure development [GO:0048856] cytoplasm [GO:0005737] ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] LMLMSGKK 15.40999985 0.470240099 923.1739767 17.67552 16.21852 15.1053 15.9458 16.78754 A0A8I3MXS3 A0A8I3MXS3_CANLF Ryanodine receptor 1 (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor) RYR1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to caffeine [GO:0071313]; intracellular calcium ion homeostasis [GO:0006874]; release of sequestered calcium ion into cytosol [GO:0051209]; response to hypoxia [GO:0001666] cell cortex [GO:0005938]; I band [GO:0031674]; plasma membrane [GO:0005886]; sarcoplasmic reticulum membrane [GO:0033017] calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; ryanodine-sensitive calcium-release channel activity [GO:0005219] VLGSGGHASNK 7.630000114 0.334636466 1027.791591 15.99504 15.00962 15.78091 17.19533 16.75933 A0A8I3MT21 A0A8I3MT21_CANLF Ryanodine receptor 2 RYR2 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion transport into cytosol [GO:0060402]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cardiac muscle contraction [GO:0060048]; cellular response to caffeine [GO:0071313]; detection of calcium ion [GO:0005513]; establishment of protein localization to endoplasmic reticulum [GO:0072599]; intracellular calcium ion homeostasis [GO:0006874]; positive regulation of sequestering of calcium ion [GO:0051284]; positive regulation of the force of heart contraction [GO:0098735]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of AV node cell action potential [GO:0098904]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of heart rate [GO:0002027]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; response to muscle activity [GO:0014850]; response to muscle stretch [GO:0035994]; response to redox state [GO:0051775]; type B pancreatic cell apoptotic process [GO:0097050] calcium channel complex [GO:0034704]; sarcoplasmic reticulum membrane [GO:0033017]; Z disc [GO:0030018] calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; protein kinase A catalytic subunit binding [GO:0034236]; protein kinase A regulatory subunit binding [GO:0034237]; ryanodine-sensitive calcium-release channel activity [GO:0005219]; suramin binding [GO:0043924] EAATPDEETEALEK 15.26000023 0.668939947 1533.11626 17.17784 0 18.1616 18.9057 16.93462 A0A8C0NJ54 A0A8C0NJ54_CANLF S100/CaBP-9k-type calcium binding subdomain domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) structural molecule activity [GO:0005198] FTLTSK 1.620000005 0.164967054 697.5886272 18.05784 14.6996 16.3277 19.44563 14.85235 A0A8C0RKL7 A0A8C0RKL7_CANLF SAM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AELTATNR 4.789999962 0.159497141 875.2615233 15.96705 16.16295 11.79613 16.13459 15.13328 A0A8C0SX97 A0A8C0SX97_CANLF SAM-dependent MTase RsmB/NOP-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] membrane [GO:0016020] methyltransferase activity [GO:0008168]; RNA binding [GO:0003723] ELPPSGVR 1.720000029 0.338018923 854.7378952 17.42163 16.52513 15.55525 19.60897 16.35823 A0A8C0RTF8 A0A8C0RTF8_CANLF SCO-spondin SSPO Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] extracellular region [GO:0005576] GVLCDGMK 6.480000019 0.275083565 879.314821 17.06772 15.17035 16.17024 16.19097 16.58478 A0A8C0NBN8 A0A8C0NBN8_CANLF "SEC24 homolog D, COPII coat complex component" SEC24D Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886] COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789] zinc ion binding [GO:0008270] VRTSTGFR 1.909999967 0.256992251 923.3874512 17.18786 14.07038 13.21154 14.93592 12.31927 A0A8I3P6G5 A0A8I3P6G5_CANLF SECIS binding protein 2 SECISBP2 Canis lupus familiaris (Dog) (Canis familiaris) "forebrain neuron development [GO:0021884]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; selenocysteine incorporation [GO:0001514]; striatum development [GO:0021756]" nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904] mRNA 3'-UTR binding [GO:0003730]; ribonucleoprotein complex binding [GO:0043021]; selenocysteine insertion sequence binding [GO:0035368] DTASGK 4.449999809 0.417699556 578.8656941 14.60073 14.18885 16.1597 16.22012 14.89475 A0A8C0SXH8 A0A8C0SXH8_CANLF SEFIR domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] interleukin-17 receptor activity [GO:0030368] DPGAPR 2 0.395196871 611.7615069 19.12897 15.42484 15.99512 17.58128 15.31006 A0A8C0NR46 A0A8C0NR46_CANLF SH2 domain-containing protein LOC100856339 Canis lupus familiaris (Dog) (Canis familiaris) MTSAITNGMK 6.880000114 0.164628611 1068.402875 11.73484 10.74531 12.44219 12.4698 0 A0A8C0PZG5 A0A8C0PZG5_CANLF SH3 and cysteine rich domain 2 Canis lupus familiaris (Dog) (Canis familiaris) sarcolemma [GO:0042383] metal ion binding [GO:0046872] LCHAPTPPPPAPTPTR 10.56000042 0 1709.806302 18.76574 0 17.25487 16.15819 12.83447 A0A8C0NG00 A0A8C0NG00_CANLF SH3 and multiple ankyrin repeat domains 3 SHANK3 Canis lupus familiaris (Dog) (Canis familiaris) "AMPA glutamate receptor clustering [GO:0097113]; associative learning [GO:0008306]; brain morphogenesis [GO:0048854]; dendritic spine morphogenesis [GO:0060997]; embryonic epithelial tube formation [GO:0001838]; gene expression [GO:0010467]; glial cell proliferation [GO:0014009]; guanylate kinase-associated protein clustering [GO:0097117]; locomotion [GO:0040011]; locomotory exploration behavior [GO:0035641]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; MAPK cascade [GO:0000165]; memory [GO:0007613]; negative regulation of actin filament bundle assembly [GO:0032232]; negative regulation of cell volume [GO:0045794]; neural precursor cell proliferation [GO:0061351]; neuromuscular process controlling balance [GO:0050885]; NMDA glutamate receptor clustering [GO:0097114]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of glutamate receptor signaling pathway [GO:1900451]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of synapse structural plasticity [GO:0051835]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic density assembly [GO:0097107]; regulation of AMPA glutamate receptor clustering [GO:1904717]; regulation of behavioral fear response [GO:2000822]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of grooming behavior [GO:2000821]; regulation of long-term synaptic depression [GO:1900452]; response to interleukin-17 [GO:0097396]; social behavior [GO:0035176]; striatal medium spiny neuron differentiation [GO:0021773]; vocalization behavior [GO:0071625]" cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; neuron spine [GO:0044309]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] ionotropic glutamate receptor binding [GO:0035255]; scaffold protein binding [GO:0097110]; structural constituent of postsynaptic density [GO:0098919] APSTTLTLRSK 5.25 0.248553816 1175.144855 19.80666 20.02647 22.03044 17.14532 16.00695 A0A8P0NAB4 A0A8P0NAB4_CANLF SH3 domain containing 19 SH3D19 Canis lupus familiaris (Dog) (Canis familiaris) DPSPGGEAR 5.099999905 0.296974296 886.25379 15.18036 0 16.70513 15.56528 15.40049 A0A8C0SDG8 A0A8C0SDG8_CANLF SH3 domain-containing protein BCAR1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] cytoplasm [GO:0005737]; focal adhesion [GO:0005925] GAAGAAGPSGR 22.64999962 0.46162879 870.8281862 18.31846 18.72977 18.57263 17.3056 18.01897 A0A8C0RDD2 A0A8C0RDD2_CANLF SH3 domain-containing protein EPS8L2 Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995]; cytoplasm [GO:0005737]; membrane [GO:0016020] LQKAAEAFK 4.420000076 0.275421918 1005.102353 13.42279 17.03235 14.29449 12.5596 16.05843 A0A8C0NVX8 A0A8C0NVX8_CANLF SH3 domain-containing protein NEBL Canis lupus familiaris (Dog) (Canis familiaris) cardiac muscle thin filament assembly [GO:0071691] stress fiber [GO:0001725]; Z disc [GO:0030018] actin filament binding [GO:0051015]; filamin binding [GO:0031005]; tropomyosin binding [GO:0005523] KASEIASQK 9.75 0.351213037 962.0916722 0 15.57201 14.50684 14.54643 16.41194 A0A8C0NYI1 A0A8C0NYI1_CANLF SH3 domain-containing protein PRAM1 Canis lupus familiaris (Dog) (Canis familiaris) integrin-mediated signaling pathway [GO:0007229] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] protein kinase binding [GO:0019901] DVQSFRR 5.789999962 0.143234173 906.8477101 12.28357 0 12.15057 10.29152 12.66214 A0A8C0PH13 A0A8C0PH13_CANLF SH3 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) actin filament capping [GO:0051693] cell cortex [GO:0005938]; cytoskeleton [GO:0005856] metal ion binding [GO:0046872] LNEASR 3.049999952 0 690.4279416 0 14.67651 13.74447 14.07415 16.49771 A0A8C0N0U9 A0A8C0N0U9_CANLF SH3 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] actin binding [GO:0003779] CLRVGK 3.910000086 0.129879918 733.5574851 16.17834 16.27489 15.42298 17.27464 15.13484 A0A8C0RBS4 A0A8C0RBS4_CANLF SIGLEC family like 1 SIGLECL1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ITAVKVEK 3 0.201544564 887.5799469 15.37713 15.31242 15.58964 16.7649 14.76718 A0A8C0SDH7 A0A8C0SDH7_CANLF SKI like proto-onco SKIL Canis lupus familiaris (Dog) (Canis familiaris) blastocyst formation [GO:0001825]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; lens fiber cell differentiation [GO:0070306]; lymphocyte homeostasis [GO:0002260]; negative regulation of cell differentiation [GO:0045596]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; regulation of cell cycle [GO:0051726]; transforming growth factor beta receptor signaling pathway [GO:0007179] nucleus [GO:0005634]; protein-containing complex [GO:0032991] "chromatin binding [GO:0003682]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; SMAD binding [GO:0046332]" IMEEVMR 9.180000305 0.46391882 923.0407712 16.13606 14.62695 17.84959 16.34667 15.99732 A0A8C0RW27 A0A8C0RW27_CANLF SKP1 component POZ domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-dependent protein catabolic process [GO:0006511] EHALTSR 9.020000458 0.401987804 813.0771938 21.70471 19.15229 0 20.76328 19.84059 A0A8C0M7N2 A0A8C0M7N2_CANLF SLAIN motif family member 1 Canis lupus familiaris (Dog) (Canis familiaris) TNGDKLR 8.489999771 0.141650904 802.5504502 0 15.67946 15.46833 16.33816 14.89092 A0A8C0MUB5 A0A8C0MUB5_CANLF SLIT-ROBO Rho GTPase activating protein 3 SRGAP3 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] GRIESPEK 6.190000057 0.300580037 916.8120604 16.96294 0 11.27003 13.77496 17.65911 A0A8C0LTG0 A0A8C0LTG0_CANLF SMB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular region [GO:0005576] polysaccharide binding [GO:0030247]; scavenger receptor activity [GO:0005044] EPTPTAPK 2.970000029 0.227526342 839.5424537 17.62423 17.41961 15.65288 16.48538 17.35546 A0A8C0NKJ8 A0A8C0NKJ8_CANLF SMP-LTD domain-containing protein TEX2 Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869] endoplasmic reticulum membrane [GO:0005789] lipid binding [GO:0008289] ARPKLGER 4.909999847 0.012653032 927.6436728 0 14.67518 15.76907 0 15.54479 A0A8C0ME19 A0A8C0ME19_CANLF SNW domain-containing protein 1 SNW1 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" spliceosomal complex [GO:0005681] GPPSPPAPVMHSPSRK 2.769999981 0.070273339 1641.340477 15.84779 17.88091 15.8573 0 14.61059 A0A8C0P0Q7 A0A8C0P0Q7_CANLF SOCS box domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] membrane [GO:0016020] GTP binding [GO:0005525]; GTPase activity [GO:0003924] AARPPQSPPK 2.5 0.305491048 1047.962502 16.50799 14.97622 18.12963 12.27711 15.3476 A0A8C0MIG1 A0A8C0MIG1_CANLF SON DNA and RNA binding protein SON Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell cycle [GO:0051726]; regulation of RNA splicing [GO:0043484] RNA binding [GO:0003723] EPILVDFK 4.070000172 0.154530926 960.8624248 16.68336 17.54646 15.91405 19.13842 16.23985 A0A8C0NPF0 A0A8C0NPF0_CANLF SPATA31/FAM205 domain-containing protein C11H9orf131 Canis lupus familiaris (Dog) (Canis familiaris) GGKTGSTDTP 7.590000153 0.268260326 919.9563818 17.85617 17.70736 0 16.51949 16.70004 A0A8C0LXJ8 A0A8C0LXJ8_CANLF SR-related CTD associated factor 1 PRR12 Canis lupus familiaris (Dog) (Canis familiaris) REGSSSSEGR 8.18999958 0.380251736 1051.19736 18.05572 15.32035 14.70846 15.30759 14.9566 A0A8C0NZE7 A0A8C0NZE7_CANLF SRCR domain-containing protein LOXL4 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; membrane [GO:0016020] "copper ion binding [GO:0005507]; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [GO:0016641]" VEVLMNR 2.269999981 0.125735121 859.5216015 15.9123 17.17119 16.35564 15.52963 16.38215 A0A8C0TRE0 A0A8C0TRE0_CANLF SSD domain-containing protein PTCHD1 Canis lupus familiaris (Dog) (Canis familiaris) excitatory chemical synaptic transmission [GO:0098976]; inhibitory chemical synaptic transmission [GO:0098977]; long-term memory [GO:0007616]; short-term memory [GO:0007614]; smoothened signaling pathway [GO:0007224]; social behavior [GO:0035176]; thalamus development [GO:0021794] plasma membrane [GO:0005886]; synapse [GO:0045202] DFTRTK 3.670000076 0.33948433 768.5553735 14.84449 17.02132 15.84025 16.52872 16.53931 A0A8C0NDA3 A0A8C0NDA3_CANLF SURP and G-patch domain containing 2 LOC100685713 Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] nucleus [GO:0005634] RNA binding [GO:0003723] VVPPTKLEVQAK 2.730000019 0.251032771 1307.967158 13.24073 16.6375 12.23983 11.61985 11.87326 A0A8C0MW09 A0A8C0MW09_CANLF "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1" SMARCA1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; hydrolase activity [GO:0016787]; nucleosome binding [GO:0031491] TAMEFQRR 1.029999971 0.267806374 1054.434996 13.35964 13.36813 14.66244 16.16179 14.04836 A0A8C0MQR5 A0A8C0MQR5_CANLF Sarcoglycan delta Canis lupus familiaris (Dog) (Canis familiaris) calcium ion homeostasis [GO:0055074]; calcium-mediated signaling [GO:0019722]; cardiac muscle cell contraction [GO:0086003]; cardiac muscle cell development [GO:0055013]; coronary vasculature morphogenesis [GO:0060977]; protein-containing complex localization [GO:0031503] sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529] EIQSRPGNALYFK 4.909999847 0.308023165 1523.299605 16.48612 14.24369 0 15.77172 17.50891 A0A8C0PSA1 A0A8C0PSA1_CANLF Scavenger receptor class B member 1 (SR-BI) SCARB1 Canis lupus familiaris (Dog) (Canis familiaris) caveola [GO:0005901] GRSGGAAMAHK 5.900000095 0.431230806 1057.4277 0 14.74091 13.32435 17.16913 12.62896 A0A8I3PZ66 A0A8I3PZ66_CANLF Secretory phospholipase A2 receptor (180 kDa secretory phospholipase A2 receptor) (M-type receptor) PLA2R1 Canis lupus familiaris (Dog) (Canis familiaris) "oxidative stress-induced premature senescence [GO:0090403]; positive regulation of arachidonic acid secretion [GO:0090238]; positive regulation of cytokine production [GO:0001819]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of podocyte apoptotic process [GO:1904635]; reactive oxygen species metabolic process [GO:0072593]; receptor-mediated endocytosis [GO:0006898]; replicative senescence [GO:0090399]" cell surface [GO:0009986]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] carbohydrate binding [GO:0030246]; phospholipase binding [GO:0043274] HGGFCYK 7.320000172 0.104259881 868.6160407 15.56889 15.29747 13.4326 14.0604 16.62584 A0A8C0MWK1 A0A8C0MWK1_CANLF Sema domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) phosphorylation [GO:0016310] plasma membrane [GO:0005886] ATP binding [GO:0005524]; kinase activity [GO:0016301]; semaphorin receptor activity [GO:0017154] ARAPAR 11.23999977 0.276458858 641.1984807 16.23227 14.47497 14.95334 15.22246 14.02188 A0A8C0N5C6 A0A8C0N5C6_CANLF Semaphorin 6D SEMA6D Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399] membrane [GO:0016020] semaphorin receptor binding [GO:0030215] VDVPTTPGVPMTSLER 7.539999962 0.084671428 1697.91622 18.12102 17.64719 19.80955 0 18.34743 A0A8C0N792 A0A8C0N792_CANLF Semaphorin 7A Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399] membrane [GO:0016020] semaphorin receptor binding [GO:0030215] GHPRSGPR 3.950000048 0.236838404 862.1348884 15.41495 17.0026 15.34234 15.01611 7.902025 A0A8I3NZ25 A0A8I3NZ25_CANLF Senataxin SETX Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to hydrogen peroxide [GO:0070301]; cellular response to retinoic acid [GO:0071300]; circadian rhythm [GO:0007623]; double-strand break repair [GO:0006302]; fibroblast growth factor receptor signaling pathway [GO:0008543]; MAPK cascade [GO:0000165]; mRNA splice site recognition [GO:0006376]; negative regulation of apoptotic process [GO:0043066]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of DNA-templated transcription initiation [GO:2000144]; positive regulation of neuron projection development [GO:0010976]; positive regulation of RNA splicing [GO:0033120]; positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled [GO:2000806]; positive regulation of transcription by RNA polymerase II [GO:0045944]; termination of RNA polymerase II transcription [GO:0006369]" cytoplasm [GO:0005737]; growth cone [GO:0030426]; intercellular bridge [GO:0045171]; nuclear body [GO:0016604]; nuclear chromosome [GO:0000228] helicase activity [GO:0004386]; identical protein binding [GO:0042802]; transcription termination site sequence-specific DNA binding [GO:0001147] DDSGSKK 3.980000019 1.23E-13 737.4183136 14.36468 16.05232 0 15.39845 13.44497 A0A8C0YZC9 A0A8C0YZC9_CANLF "Sentan, cilia apical structure protein" SNTN Canis lupus familiaris (Dog) (Canis familiaris) cilium [GO:0005929] transition metal ion binding [GO:0046914] NLLQTQFR 25.09000015 0.011376459 1018.84919 21.22604 23.6038 23.00039 0 23.31874 A0A8C0PUW8 A0A8C0PUW8_CANLF Septin-10 SEPTIN10 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] GTP binding [GO:0005525] LTIVNTVGFGDQINK 4.110000134 0.384443117 1618.409678 16.22328 0 17.2814 16.10311 0 A0A8C0NKK9 A0A8C0NKK9_CANLF Septin-7 Canis lupus familiaris (Dog) (Canis familiaris) cell cycle [GO:0007049]; spermatogenesis [GO:0007283] cleavage furrow [GO:0032154]; kinetochore [GO:0000776]; motile cilium [GO:0031514]; septin complex [GO:0031105] GTP binding [GO:0005525] MPVKSCSK 2.930000067 0.022316579 953.1531888 14.21859 11.65562 13.93346 12.78864 12.45062 A0A8C0LYA3 A0A8C0LYA3_CANLF Serine protease hepsin HPN Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252]; serine-type exopeptidase activity [GO:0070008] TLPGPGARGR 10.19999981 0.039849366 982.476518 16.38697 0 13.79744 14.13064 15.58577 A0A8C0M746 A0A8C0M746_CANLF "Serine/arginine-rich splicing factor 2 (Splicing component, 35 kDa) (Splicing factor SC35) (Splicing factor, arginine/serine-rich 2)" SRSF2 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" cytosol [GO:0005829]; nuclear speck [GO:0016607]; spliceosomal complex [GO:0005681] pre-mRNA binding [GO:0036002] RYGGGGYGR 10.73999977 0.132492809 942.2133604 13.98485 13.48188 12.07937 13.05515 13.81428 A0A8C0M072 A0A8C0M072_CANLF Serine/threonine kinase 32B STK32B Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] VHYSSTWCK 1.730000019 0.433820262 1167.683978 15.38864 0 14.62616 14.60082 13.84138 A0A8C0Q9R4 A0A8C0Q9R4_CANLF Serine/threonine-protein kinase ATR (EC 2.7.11.1) ATR Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to gamma radiation [GO:0071480]; cellular response to UV [GO:0034644]; DNA damage checkpoint signaling [GO:0000077]; double-strand break repair [GO:0006302]; establishment of RNA localization to telomere [GO:0097694]; negative regulation of DNA replication [GO:0008156]; nuclear membrane disassembly [GO:0051081]; phosphorylation [GO:0016310]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of telomerase catalytic core complex assembly [GO:1904884]; protein localization to chromosome, telomeric region [GO:0070198]; replicative senescence [GO:0090399]; response to mechanical stimulus [GO:0009612]" ATR-ATRIP complex [GO:0070310]; Golgi apparatus [GO:0005794]; nuclear envelope [GO:0005635]; PML body [GO:0016605]; site of DNA damage [GO:0090734] ATP binding [GO:0005524]; histone H2AXS139 kinase activity [GO:0035979]; MutLalpha complex binding [GO:0032405]; MutSalpha complex binding [GO:0032407] AAALSEKLK 3.890000105 0.042164176 931.390629 15.0809 17.25501 16.27094 16.56379 16.16936 A0A8C0MSH2 A0A8C0MSH2_CANLF Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre-mRNA-processing factor 4 homolog) PRPF4B Canis lupus familiaris (Dog) (Canis familiaris) "mRNA cis splicing, via spliceosome [GO:0045292]" catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] VKIEDK 5.889999866 0.342208781 730.0073838 17.59262 14.53734 15.81297 18.1244 15.55815 E2RJI4 GWL_CANLF Serine/threonine-protein kinase greatwall (GW) (GWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) MASTL GW GWL Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; DNA damage response [GO:0006974]; G2/M transition of mitotic cell cycle [GO:0000086]; intracellular signal transduction [GO:0035556]; mitotic cell cycle [GO:0000278]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; phosphorylation [GO:0016310] centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein phosphatase 2A binding [GO:0051721]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] HGIIHR 3.640000105 0.286725264 733.1649911 0 13.52172 0 15.17252 16.31253 A0A8C0RS42 A0A8C0RS42_CANLF Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B PPP2R2A Canis lupus familiaris (Dog) (Canis familiaris) protein phosphatase type 2A complex [GO:0000159] protein phosphatase regulator activity [GO:0019888] VWKGDR 4.230000019 0.220741598 760.6572028 14.67439 14.94333 17.84843 14.66571 15.09358 A0A8C0M4Z5 A0A8C0M4Z5_CANLF Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] protein phosphatase type 2A complex [GO:0000159] protein phosphatase regulator activity [GO:0019888] IMEPLFR 33.63999939 0.281017146 904.7480331 17.19178 16.29419 15.54348 16.17673 15.5437 A0A8C0PSR4 A0A8C0PSR4_CANLF Serine/threonine/tyrosine interacting like 2 STYXL2 Canis lupus familiaris (Dog) (Canis familiaris) dephosphorylation [GO:0016311] protein tyrosine/serine/threonine phosphatase activity [GO:0008138] EMDGSITK 5.079999924 0.37742991 897.9475329 16.34634 14.87341 16.95751 15.91792 15.47359 A0A8C0MKY4 A0A8C0MKY4_CANLF Serotransferrin (Beta-1 metal-binding globulin) (Siderophilin) LOC477072 Canis lupus familiaris (Dog) (Canis familiaris) intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] extracellular space [GO:0005615] ferric iron binding [GO:0008199] SYLGAEYITAVANLR 56.02999878 0.810814972 1639.826836 0 15.3254 0 17.28247 0 A0A8C0T2X2 A0A8C0T2X2_CANLF Serpin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615]; membrane [GO:0016020] serine-type endopeptidase inhibitor activity [GO:0004867] AINKWVK 4.300000191 0.124140211 857.5046955 0 15.85042 12.1285 0 13.12642 A0A8C0PI76 A0A8C0PI76_CANLF Serum amyloid A like 1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ETVARGLK 4.269999981 2.43E-13 874.413617 15.98528 14.65031 14.29903 11.1652 14.9145 A0A8C0TV22 A0A8C0TV22_CANLF Shootin-1 SHTN1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum polarization [GO:0061163]; neuron projection morphogenesis [GO:0048812]; positive regulation of neuron migration [GO:2001224]; regulation of establishment of cell polarity [GO:2000114] axonal growth cone [GO:0044295]; cell leading edge [GO:0031252]; filopodium [GO:0030175]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471] kinesin binding [GO:0019894] MNSSDEEK 1.830000043 0.148825678 938.9407933 13.20553 13.19066 0 17.36325 14.14684 A0A8C0MWE9 A0A8C0MWE9_CANLF Short coiled-coil protein LOC100683388 Canis lupus familiaris (Dog) (Canis familiaris) MNADMDAVDAK 2.549999952 0.244052654 1211.763591 14.03664 0 11.54753 0 12.19702 A0A8C0M7Y1 A0A8C0M7Y1_CANLF Signal induced proliferation associated 1 like 2 SIPA1L2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of small GTPase mediated signal transduction [GO:0051056] GTPase activator activity [GO:0005096] DCSKELACK 1.620000005 0.077956388 1111.25435 13.65637 14.16754 14.77074 9.975211 12.47389 A0A8P0P2H7 A0A8P0P2H7_CANLF Signal recognition particle subunit SRP68 SRP68 Canis lupus familiaris (Dog) (Canis familiaris) SRP-dependent cotranslational protein targeting to membrane [GO:0006614] "nucleolus [GO:0005730]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]" 7S RNA binding [GO:0008312]; endoplasmic reticulum signal peptide binding [GO:0030942]; signal recognition particle binding [GO:0005047] MAAEKQVPGGGGGGGGGGGSGGGR 8.079999924 2.54E-13 1930.007106 0 16.82728 0 11.16583 11.46029 A0A8C0NH06 A0A8C0NH06_CANLF Signal transducer and activator of transcription STAT1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to interferon-beta [GO:0035458]; defense response to virus [GO:0051607]; interleukin-27-mediated signaling pathway [GO:0070106]; interleukin-9-mediated signaling pathway [GO:0038113]; macrophage derived foam cell differentiation [GO:0010742]; negative regulation by virus of viral protein levels in host cell [GO:0046725]; negative regulation of angiogenesis [GO:0016525]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of endothelial cell proliferation [GO:0001937]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor signaling pathway via JAK-STAT [GO:0007259]; renal tubule development [GO:0061326]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; type I interferon-mediated signaling pathway [GO:0060337]; type II interferon-mediated signaling pathway [GO:0060333] chromatin [GO:0000785]; cytosol [GO:0005829]; ISGF3 complex [GO:0070721]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone acetyltransferase binding [GO:0035035]; histone binding [GO:0042393]; nuclear receptor binding [GO:0016922]; promoter-specific chromatin binding [GO:1990841]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; transcription coactivator binding [GO:0001223]; transcription corepressor binding [GO:0001222]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin-like protein ligase binding [GO:0044389]" NTVKGFR 8.869999886 0.308069853 821.1082869 16.00832 21.32685 14.87683 18.45269 15.9852 A0A8C0NL42 A0A8C0NL42_CANLF Signal transducer and activator of transcription STAT4 Canis lupus familiaris (Dog) (Canis familiaris) response to organic substance [GO:0010033]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] TIQTMDQGDK 5.880000114 0.211804061 1152.810723 16.63142 14.7732 14.02223 10.6249 14.46107 A0A8I3RXB9 A0A8I3RXB9_CANLF Signal transducer and activator of transcription STAT6 Canis lupus familiaris (Dog) (Canis familiaris) interleukin-4-mediated signaling pathway [GO:0035771]; isotype switching to IgE isotypes [GO:0048289]; mammary gland epithelial cell proliferation [GO:0033598]; mammary gland morphogenesis [GO:0060443]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type 2 immune response [GO:0002829]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of isotype switching to IgE isotypes [GO:0048295]; regulation of mast cell proliferation [GO:0070666]; T-helper 1 cell lineage commitment [GO:0002296] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; identical protein binding [GO:0042802]; protein phosphatase binding [GO:0019903]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ADMVTEKQAR 3.829999924 0.262922303 1165.096871 12.9147 14.03011 15.28366 16.17882 15.39188 A0A8P0PRJ4 A0A8P0PRJ4_CANLF Signal transducing adaptor molecule 2 STAM2 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] early endosome membrane [GO:0031901] phosphatidylinositol binding [GO:0035091]; ubiquitin binding [GO:0043130] VGAAPGRR 9.550000191 0.195386713 783.1001797 15.93735 14.9242 17.85178 15.93352 15.63803 A0A8C0PKV0 A0A8C0PKV0_CANLF Single-pass membrane protein with coiled-coil domains 3 SMCO3 LOC100686619 Canis lupus familiaris (Dog) (Canis familiaris) LEPTLYR 8.890000343 0.293671066 891.1396293 16.05294 15.15726 14.42861 13.911 15.60742 A0A8C0LTZ1 A0A8C0LTZ1_CANLF Sm domain-containing protein ATXN2L Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] ESPSLASR 6.010000229 0.278303339 842.8214046 17.19612 14.87807 15.60637 14.76555 15.63605 A0A8I3P4C0 A0A8I3P4C0_CANLF Sm protein F Canis lupus familiaris (Dog) (Canis familiaris) spliceosomal snRNP assembly [GO:0000387] Sm-like protein family complex [GO:0120114]; spliceosomal complex [GO:0005681] DGEMREQHLLWGIFK 4.320000172 0.505566925 1860.329243 0 0 0 17.06047 18.90057 A0A8C0N2N1 A0A8C0N2N1_CANLF Sodium channel and clathrin linker 1 SCLT1 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; clustering of voltage-gated sodium channels [GO:0045162] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary transition fiber [GO:0097539] EMEDSNR 4.019999981 0.291823356 895.3594909 12.85376 14.89548 14.95953 14.28564 12.64995 A0A8C0TS11 A0A8C0TS11_CANLF Sodium channel protein SCN7A Canis lupus familiaris (Dog) (Canis familiaris) cellular homeostasis [GO:0019725]; response to bacterium [GO:0009617]; sodium ion homeostasis [GO:0055078] glial cell projection [GO:0097386]; voltage-gated sodium channel complex [GO:0001518] voltage-gated sodium channel activity [GO:0005248] INPGTQVR 1.00999999 0.313667234 884.0444398 17.98992 14.95725 18.5792 14.8537 15.57234 A0A8C0Z3U5 A0A8C0Z3U5_CANLF Solute carrier family 15 member 2 (Peptide transporter 2) Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087] apical plasma membrane [GO:0016324]; phagocytic vesicle membrane [GO:0030670] oligopeptide transmembrane transporter activity [GO:0035673]; symporter activity [GO:0015293] HAEERTR 5.590000153 0.221080839 899.6447821 17.3869 15.0678 13.08669 15.19807 14.51668 A0A8C0NR07 A0A8C0NR07_CANLF Solute carrier family 25 member 15 SLC25A15 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] IQVLSMSGK 2.210000038 0.18524089 977.0073726 14.13939 16.7159 13.19649 14.65996 14.46573 A0A8C0MI03 A0A8C0MI03_CANLF Solute carrier family 25 member 47 SLC25A47 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741] acetyl-CoA transmembrane transporter activity [GO:0008521]; NAD transmembrane transporter activity [GO:0051724] EEGPRVLFK 8.979999542 0.111561464 1074.798961 15.3744 14.27668 0 13.71334 15.29449 A0A8I3S7U6 A0A8I3S7U6_CANLF Solute carrier family 30 member 4 SLC30A4 Canis lupus familiaris (Dog) (Canis familiaris) response to toxic substance [GO:0009636]; zinc export across plasma membrane [GO:0140882]; zinc ion import into lysosome [GO:0140916] late endosome [GO:0005770]; membrane [GO:0016020] zinc ion transmembrane transporter activity [GO:0005385] MKSNSK 1.840000033 0.343577342 710.766148 16.74936 14.20553 15.41094 15.62664 16.27548 A0A8C0P0C2 A0A8C0P0C2_CANLF Solute carrier family 6 member 15 SLC6A15 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] MEPRVWR 1.899999976 0.298879543 972.5674023 15.70109 15.27098 16.98626 15.94177 15.47022 A0A8C0LZ07 A0A8C0LZ07_CANLF Solute carrier family 66 member 2 (PQ-loop repeat-containing protein 1) SLC66A2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FFAAADNK 3.170000076 0.274934962 883.6470302 14.14708 13.02852 14.8814 0 13.05917 A0A8C0SY52 A0A8C0SY52_CANLF Solute carrier organic anion transporter family member SLCO2B1 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transport [GO:0006811]; transmembrane transport [GO:0055085] plasma membrane [GO:0005886] MPDKDTK 8.359999657 0.288630524 849.5847849 16.32376 16.40144 18.31395 17.11958 17.38143 A0A8C0TQC9 A0A8C0TQC9_CANLF Sorbin and SH3 domain containing 1 SORBS1 Canis lupus familiaris (Dog) (Canis familiaris) HEAVGNK 5.190000057 0.407533453 753.7746737 16.50704 16.11826 16.64869 17.26668 15.29252 A0A8C0NGR8 A0A8C0NGR8_CANLF Sorting nexin 25 SNX25 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] phosphatidylinositol binding [GO:0035091] FMEKSK 3.380000114 0.391362628 785.2832538 18.39778 14.82466 0 0 14.87769 A0A8C0NWE2 A0A8C0NWE2_CANLF Sosondowah ankyrin repeat domain family member D SOWAHD Canis lupus familiaris (Dog) (Canis familiaris) GTAGPGPK 9.590000153 0.454698627 684.7903278 17.98022 16.99846 0 15.75681 16.64828 A0A8C0M5Z3 A0A8C0M5Z3_CANLF Sp2 transcription factor SP2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] NSFGILSSK 9.050000191 0.297156536 953.0572344 14.92402 15.99665 13.34034 17.17337 16.98524 A0A8C0SAR4 A0A8C0SAR4_CANLF "Spectrin beta, non-erythrocytic 4" SPTBN4 Canis lupus familiaris (Dog) (Canis familiaris) LMARDGTR 3.220000029 0.332221441 920.7063996 12.97485 18.268 14.40831 14.66514 15.46375 A0A8C0RK63 A0A8C0RK63_CANLF Spermatid maturation protein 1 N-terminal domain-containing protein SPEM1 Canis lupus familiaris (Dog) (Canis familiaris) flagellated sperm motility [GO:0030317]; sperm individualization [GO:0007291] cytoplasm [GO:0005737]; membrane [GO:0016020] EASKSSSPGK 9.119999886 0.299347375 977.2314254 13.86866 15.00716 14.23057 14.94288 14.94996 A0A8C0QBK2 A0A8C0QBK2_CANLF Spermatogenesis associated 24 SPATA24 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; identical protein binding [GO:0042802] DQLITK 16.65999985 0.403742367 718.2799807 16.41233 17.37822 0 0 0 A0A8C0QFP9 A0A8C0QFP9_CANLF Spermatogenic leucine zipper 1 SPZ1 Canis lupus familiaris (Dog) (Canis familiaris) DNA-binding transcription factor activity [GO:0003700] ALDETQLSK 5.940000057 1.22E-13 1004.492636 13.57357 10.51002 9.905955 0 9.289473 A0A8C0P6J2 A0A8C0P6J2_CANLF Sphingosine-1-phosphate receptor 2 S1PR2 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; excitatory postsynaptic potential [GO:0060079]; filopodium assembly [GO:0046847]; negative regulation of excitatory postsynaptic potential [GO:0090394]; positive regulation of establishment of endothelial barrier [GO:1903142]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800] plasma membrane [GO:0005886]; postsynapse [GO:0098794] G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor binding [GO:0001664]; integrin binding [GO:0005178]; sphingosine-1-phosphate receptor activity [GO:0038036] VKLYGSDK 4.090000153 0.217260564 908.8092843 13.86583 15.5256 15.90846 16.0963 16.74498 A0A8C0MPE4 A0A8C0MPE4_CANLF Spindle and kinetochore-associated protein 2 (Protein FAM33A) SKA2 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; chromosome segregation [GO:0007059] cytoplasm [GO:0005737]; outer kinetochore [GO:0000940]; spindle microtubule [GO:0005876] microtubule binding [GO:0008017] SFMSDL 4.199999809 0.374143741 716.7475619 18.12975 16.61963 16.93593 16.05351 16.05061 A0A8C0QD37 A0A8C0QD37_CANLF Splicing factor YJU2 YJU2 Canis lupus familiaris (Dog) (Canis familiaris) generation of catalytic spliceosome for first transesterification step [GO:0000349] U2-type catalytic step 1 spliceosome [GO:0071006] metal ion binding [GO:0046872] ETAALVEEAR 10.05000019 0.183193335 1087.740675 14.61157 12.56997 0 13.59147 17.64308 A0A8C0PEH2 A0A8C0PEH2_CANLF StAR related lipid transfer domain containing 13 STARD13 Canis lupus familiaris (Dog) (Canis familiaris) endothelial cell migration [GO:0043542]; endothelial tube lumen extension [GO:0097498]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; signal transduction [GO:0007165] GTPase activator activity [GO:0005096]; lipid binding [GO:0008289] LTHICR 5.210000038 0.365115222 799.6604098 17.17488 15.87529 15.44579 16.56618 16.12155 A0A8C0TF65 A0A8C0TF65_CANLF StAR related lipid transfer domain containing 8 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] GTPase activator activity [GO:0005096]; lipid binding [GO:0008289] MSPEVEAK 12.31999969 0 886.3094089 15.0344 17.02145 0 15.26468 15.81594 A0A8C0TQV1 A0A8C0TQV1_CANLF Starch binding domain 1 STBD1 Canis lupus familiaris (Dog) (Canis familiaris) glycogen catabolic process [GO:0005980]; glycophagy [GO:0061723]; intracellular transport [GO:0046907]; substrate localization to autophagosome [GO:0061753] endoplasmic reticulum [GO:0005783]; perinuclear region of cytoplasm [GO:0048471]; T-tubule [GO:0030315] cargo receptor activity [GO:0038024]; enzyme binding [GO:0019899]; glycogen binding [GO:2001069]; starch binding [GO:2001070] VVQKWWGIP 1.220000029 0.252995079 1111.737813 14.37968 15.30492 15.19352 14.01719 11.79389 A0A8I3PWT9 A0A8I3PWT9_CANLF Staufen double-stranded RNA binding protein 2 STAU2 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] SPQVIKESGPPHMK 3.900000095 2.46E-13 1533.614195 14.91841 16.20005 14.40559 13.45827 0 A0A8C0MV33 A0A8C0MV33_CANLF Stress-activated protein kinase JNK (EC 2.7.11.24) MAPK10 Canis lupus familiaris (Dog) (Canis familiaris) phosphorylation [GO:0016310]; rhythmic process [GO:0048511] cytoplasm [GO:0005737] ATP binding [GO:0005524]; MAP kinase activity [GO:0004707]; protein serine kinase activity [GO:0106310] MLVIDPAKR 2.769999981 0.426776583 1058.979266 14.76136 14.3129 16.70434 16.06797 15.07971 A0A8C0N111 A0A8C0N111_CANLF Striated muscle enriched protein kinase SPEG Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] DQFPLTRGR 4.260000229 0.057563212 1090.332045 13.72623 14.95278 17.11849 14.70341 10.77717 A0A8C0NIZ8 A0A8C0NIZ8_CANLF Structural maintenance of chromosomes protein 5 Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair via homologous recombination [GO:0000724] "chromosome, telomeric region [GO:0000781]; nucleus [GO:0005634]; Smc5-Smc6 complex [GO:0030915]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] MATPSR 11.77000046 0.335069181 663.3024851 18.47179 16.51097 13.91057 17.42171 18.113 A0A8I3MF53 A0A8I3MF53_CANLF Structure-specific endonuclease subunit SLX4 SLX4 Canis lupus familiaris (Dog) (Canis familiaris) DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; nucleotide-excision repair [GO:0006289]; positive regulation of t-circle formation [GO:1904431]; response to intra-S DNA damage checkpoint signaling [GO:0072429]; t-circle formation [GO:0090656]; telomeric D-loop disassembly [GO:0061820] "cell junction [GO:0030054]; chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; ERCC4-ERCC1 complex [GO:0070522]; Holliday junction resolvase complex [GO:0048476]; nucleoplasm [GO:0005654]; Slx1-Slx4 complex [GO:0033557]" DNA binding [GO:0003677]; enzyme activator activity [GO:0008047]; metal ion binding [GO:0046872] AQLGATSGPLLQRSK 3.460000038 0 1527.622075 15.68057 0 16.60847 14.87584 15.98069 A0A8P0NYY1 A0A8P0NYY1_CANLF Submaxillary mucin-like protein LOC102157106 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] RIAMAR 5.460000038 0.274247834 733.2356405 16.16755 14.32587 18.36737 0 18.4896 A0A8C0PUZ8 A0A8C0PUZ8_CANLF Sulfhydryl oxidase (EC 1.8.3.2) QSOX1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix assembly [GO:0085029]; negative regulation of macroautophagy [GO:0016242] extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; intercellular bridge [GO:0045171] FAD binding [GO:0071949]; flavin-dependent sulfhydryl oxidase activity [GO:0016971]; protein disulfide isomerase activity [GO:0003756] NGSTSR 4.690000057 0 622.3207824 11.11639 14.76528 14.04311 0 15.57562 A0A8C0SJL5 A0A8C0SJL5_CANLF Superoxide dismutase copper chaperone CCS Canis lupus familiaris (Dog) (Canis familiaris) superoxide metabolic process [GO:0006801] cytoplasm [GO:0005737]; nucleus [GO:0005634] copper ion binding [GO:0005507] EPAKPPAHL 3.589999914 0.387323668 960.90362 16.39033 13.54292 15.78425 0 13.12182 A0A8C0N2S5 A0A8C0N2S5_CANLF Suppressor of cytokine signaling 1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; protein ubiquitination [GO:0016567] SQAEYRR 5.199999809 0.029489331 910.2514161 12.76818 12.00246 13.93926 8.143586 9.418466 A0A8P0PM58 A0A8P0PM58_CANLF Suppressor of tumorigenicity 7 protein-like ST7L Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VHLYSEFR 2.890000105 0.062394514 1050.523203 15.5237 14.5684 13.85496 13.71937 17.04973 O02771 SMN_CANLF Survival motor neuron protein SMN1 SMN Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription termination [GO:0006353]; nervous system development [GO:0007399]; spliceosomal snRNP assembly [GO:0000387] axon [GO:0030424]; Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]; Z disc [GO:0030018] RNA binding [GO:0003723] KNATTALK 9.430000305 0.327719344 846.1911839 16.73524 17.40252 18.70432 17.66198 17.91047 A0A8C0PCW8 A0A8C0PCW8_CANLF Sushi domain-containing protein CFH Canis lupus familiaris (Dog) (Canis familiaris) ATCTDVGWVPLPR 4.949999809 0 1471.805492 18.12398 15.68789 17.74829 0 0 A0A8C0N1A4 A0A8C0N1A4_CANLF Sushi domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LVGPQSITCLESR 65.26999664 0.006739505 1459.818308 16.57808 14.23593 17.26434 18.12313 19.22554 A0A8C0M8Y3 A0A8C0M8Y3_CANLF Synaptopodin SYNPO Canis lupus familiaris (Dog) (Canis familiaris) organelle [GO:0043226] MEGCSEK 1.24000001 0.312696972 857.9345571 16.50137 16.79809 16.31613 18.73545 16.12565 A0A8I3NCR2 A0A8I3NCR2_CANLF Synaptotagmin 9 SYT9 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LNHQSSK 11.28999996 0 814.6089601 12.8572 0 11.70363 12.2038 14.59056 A0A8C0PY28 A0A8C0PY28_CANLF Synaptotagmin like 1 SYTL1 Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887]; intracellular protein transport [GO:0006886] plasma membrane [GO:0005886] small GTPase binding [GO:0031267] TNLVPRT 7.440000057 0.31701549 800.7196472 16.77188 15.74045 16.41065 16.48097 0 A0A8C0MM93 A0A8C0MM93_CANLF Synaptotagmin like 2 SYTL2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] small GTPase binding [GO:0031267] SSELSR 8.609999657 0.351142254 677.8106528 0 0 15.17024 0 17.45469 A0A8C0TBL7 A0A8C0TBL7_CANLF Syntaxin binding protein 5L STXBP5L Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887]; glucose homeostasis [GO:0042593]; negative regulation of insulin secretion [GO:0046676]; regulation of synaptic vesicle exocytosis [GO:2000300] neuromuscular junction [GO:0031594]; neuronal dense core vesicle [GO:0098992]; plasma membrane [GO:0005886] NEIPAVK 5.579999924 0.269316142 770.4026345 16.17483 14.64824 14.64367 13.48536 13.63152 A0A8C0MZL9 A0A8C0MZL9_CANLF Syntaxin-binding protein 1 (Protein unc-18 homolog 1) (Protein unc-18 homolog A) STXBP1 Canis lupus familiaris (Dog) (Canis familiaris) "axon target recognition [GO:0007412]; cellular response to type II interferon [GO:0071346]; long-term synaptic depression [GO:0060292]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; neuromuscular synaptic transmission [GO:0007274]; neuron apoptotic process [GO:0051402]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; presynaptic dense core vesicle exocytosis [GO:0099525]; protein transport [GO:0015031]; synaptic vesicle maturation [GO:0016188]; synaptic vesicle priming [GO:0016082]; vesicle docking involved in exocytosis [GO:0006904]" axon [GO:0030424]; extrinsic component of presynaptic membrane [GO:0098888]; glutamatergic synapse [GO:0098978]; parallel fiber to Purkinje cell synapse [GO:0098688]; phagocytic vesicle [GO:0045335]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic active zone membrane [GO:0048787]; presynaptic cytosol [GO:0099523] syntaxin-1 binding [GO:0017075] RMNTGEK 7.940000057 0.041057212 851.3295833 19.13541 15.95561 18.29659 19.03799 17.97904 A0A8I3N7S2 A0A8I3N7S2_CANLF Synuclein alpha interacting protein SNCAIP Canis lupus familiaris (Dog) (Canis familiaris) dopamine metabolic process [GO:0042417]; regulation of inclusion body assembly [GO:0090083]; regulation of neurotransmitter secretion [GO:0046928] cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleoplasm [GO:0005654] identical protein binding [GO:0042802]; ubiquitin protein ligase binding [GO:0031625] TIPELCRR 3.420000076 0.302830636 1044.697785 15.15471 15.08377 16.14053 14.82723 14.43993 A0A8C0RTW0 A0A8C0RTW0_CANLF T-box transcription factor 3 TBX3 Canis lupus familiaris (Dog) (Canis familiaris) "anterior/posterior axis specification, embryo [GO:0008595]; atrioventricular bundle cell differentiation [GO:0003167]; atrioventricular canal morphogenesis [GO:1905222]; blood vessel development [GO:0001568]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac jelly development [GO:1905072]; cardiac muscle cell fate commitment [GO:0060923]; cellular senescence [GO:0090398]; DNA-templated transcription [GO:0006351]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; endocardial cushion formation [GO:0003272]; female genitalia development [GO:0030540]; follicle-stimulating hormone secretion [GO:0046884]; heart looping [GO:0001947]; hepatoblast differentiation [GO:0061017]; in utero embryonic development [GO:0001701]; limbic system development [GO:0021761]; luteinizing hormone secretion [GO:0032275]; male genitalia development [GO:0030539]; mammary placode formation [GO:0060596]; mesoderm morphogenesis [GO:0048332]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell proliferation involved in heart morphogenesis [GO:2000137]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of stem cell differentiation [GO:2000737]; outflow tract morphogenesis [GO:0003151]; positive regulation of cell cycle [GO:0045787]; positive regulation of stem cell proliferation [GO:2000648]; regulation of protein complex stability [GO:0061635]; regulation of protein stability [GO:0031647]; roof of mouth development [GO:0060021]; semicircular canal morphogenesis [GO:0048752]; sinoatrial node cell development [GO:0060931]; skeletal system development [GO:0001501]; smooth muscle cell differentiation [GO:0051145]; specification of animal organ position [GO:0010159]; stem cell population maintenance [GO:0019827]; stem cell proliferation [GO:0072089]; ureteric peristalsis [GO:0072105]; ventricular septum morphogenesis [GO:0060412]" cilium [GO:0005929]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]" GSPALK 4.130000114 0.173783305 572.839781 18.95862 18.99303 16.04899 18.32052 17.45069 A0A8C0YYU7 A0A8C0YYU7_CANLF T-complex 11 TCP11 Canis lupus familiaris (Dog) (Canis familiaris) PDVEDR 3.869999886 0 731.5071547 14.02599 11.38805 13.08597 14.06498 0 A0A8C0TIJ9 A0A8C0TIJ9_CANLF T-complex protein 1 subunit epsilon (CCT-epsilon) CCT5 Canis lupus familiaris (Dog) (Canis familiaris) binding of sperm to zona pellucida [GO:0007339]; chaperone-mediated protein folding [GO:0061077]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein stabilization [GO:0050821]; response to virus [GO:0009615] cell body [GO:0044297]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; beta-tubulin binding [GO:0048487]; G-protein beta-subunit binding [GO:0031681]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; unfolded protein binding [GO:0051082] QQISLATQMVR 4.139999866 0 1290.031601 18.83064 16.60429 16.9383 17.39435 17.15782 A0A8C0RFQ9 A0A8C0RFQ9_CANLF T-complex-associated-testis-expressed 1 TCTE1 Canis lupus familiaris (Dog) (Canis familiaris) flagellated sperm motility [GO:0030317] cytoplasm [GO:0005737]; sperm flagellum [GO:0036126] GWKSGANVR 10.11999989 0.083582514 973.9864728 11.53553 13.06325 13.75123 13.70896 12.11452 A0A8C0PL83 A0A8C0PL83_CANLF TATA-box binding protein associated factor 4b TAF4B Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription initiation [GO:0006352]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261] fibrillar center [GO:0001650]; transcription factor TFIID complex [GO:0005669] DNA binding [GO:0003677]; NF-kappaB binding [GO:0051059]; protein heterodimerization activity [GO:0046982] NFLAMLIK 7.840000153 0.281668558 965.8077109 17.88621 18.81486 17.29777 19.77563 18.88247 A0A8C0NBH1 A0A8C0NBH1_CANLF TBC1 domain family member 21 TBC1D21 Canis lupus familiaris (Dog) (Canis familiaris) sperm axoneme assembly [GO:0007288]; sperm mitochondrial sheath assembly [GO:0120317] acrosomal vesicle [GO:0001669]; sperm midpiece [GO:0097225] actin binding [GO:0003779]; GTPase activator activity [GO:0005096] LTVDSTRR 4.909999847 0.006125415 947.106449 14.70257 13.16717 14.8674 12.91105 11.88795 A0A8C0T6E2 A0A8C0T6E2_CANLF TBC1 domain family member 25 TBC1D25 Canis lupus familiaris (Dog) (Canis familiaris) GRPVRQR 4.960000038 0.362571193 869.1713594 15.00817 15.43962 15.21671 13.04353 14.06802 A0A8C0SZI2 A0A8C0SZI2_CANLF TBC1 domain family member 7 TBC1D7 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765] GTPase activator activity [GO:0005096] KSLEILLK 3.150000095 1.22E-13 942.5119206 15.20494 15.99864 10.42016 11.3023 13.55564 A0A8C0RR13 A0A8C0RR13_CANLF TBC1 domain family member 8B TBC1D8B Canis lupus familiaris (Dog) (Canis familiaris) glomerular filtration [GO:0003094]; vesicle-mediated transport [GO:0016192] cytosol [GO:0005829] calcium ion binding [GO:0005509] TSQLSCR 3.970000029 0.320989396 851.7772992 16.18702 15.60105 15.31115 15.58907 12.20741 A0A8C0N581 A0A8C0N581_CANLF TIAM Rac1 associated GEF 1 TIAM1 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] KLNTEI 5.71999979 0.29466343 718.075926 17.43867 15.2989 17.44279 16.53339 15.32118 A0A8C0RF16 A0A8C0RF16_CANLF TIAM Rac1 associated GEF 2 TIAM2 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] KANSTK 3.230000019 0.256170873 647.7330652 17.24866 15.74293 14.35872 19.10941 0 A0A8C0TTC0 A0A8C0TTC0_CANLF TLC domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]" membrane [GO:0016020] VHPAEPR 7.989999771 0.128784298 804.2460658 16.79524 17.05731 17.61279 16.27404 16.29958 A0A8C0QQB6 A0A8C0QQB6_CANLF TMEM9 domain family member B TMEM9B NRIP3 Canis lupus familiaris (Dog) (Canis familiaris) lysosomal membrane [GO:0005765] SVFDRHVVLS 7.949999809 0.077707857 1159.730886 9.750396 13.18961 13.93302 14.63507 14.36472 A0A8C0PHG0 A0A8C0PHG0_CANLF TOG domain-containing protein CLASP2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cytoskeleton organization [GO:0051494]; negative regulation of supramolecular fiber organization [GO:1902904]; regulation of microtubule polymerization or depolymerization [GO:0031110] cytoplasm [GO:0005737]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630] microtubule binding [GO:0008017] KPGSAGGPK 5.659999847 0 798.5128029 15.36893 15.27403 13.43989 14.6917 12.29766 A0A8C0NFI6 A0A8C0NFI6_CANLF TRASH domain-containing protein ZMYM4 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] RLDKPHK 5.289999962 0.213365798 895.1121294 17.05817 15.05281 14.63129 13.94773 0 A0A8C0S0K0 A0A8C0S0K0_CANLF TRASH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein dimerization activity [GO:0046983]; zinc ion binding [GO:0008270] GNMNITLIFK 2.859999895 0 1167.40081 13.65717 0 14.69178 0 15.37362 A0A8I3PBD5 A0A8I3PBD5_CANLF TSPO associated protein 1 TSPOAP1 Canis lupus familiaris (Dog) (Canis familiaris) calyx of Held [GO:0044305]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739] benzodiazepine receptor binding [GO:0030156]; voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels [GO:0099626] AHSGPNPSPR 8.680000305 0.173026558 1020.378395 15.38184 19.62902 14.02659 0 14.2489 A0A8C0SER8 A0A8C0SER8_CANLF Talin 1 TLN1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; cell-substrate junction assembly [GO:0007044]; cortical actin cytoskeleton organization [GO:0030866]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229] adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925]; ruffle [GO:0001726] actin filament binding [GO:0051015]; integrin binding [GO:0005178]; LIM domain binding [GO:0030274]; phosphatidylinositol binding [GO:0035091]; phosphatidylserine binding [GO:0001786]; structural constituent of cytoskeleton [GO:0005200]; vinculin binding [GO:0017166] GTPQDLAR 5.389999866 0.201748276 856.7890165 12.212 15.45764 14.53018 15.04423 16.72403 A0A8C0MQ45 A0A8C0MQ45_CANLF Talin 2 TLN2 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925]; ruffle [GO:0001726] actin filament binding [GO:0051015]; structural constituent of cytoskeleton [GO:0005200] EGGGNPK 5.010000229 0.309758097 657.5470444 15.20309 15.4622 16.12509 16.83398 15.12277 A0A8C0NFK7 A0A8C0NFK7_CANLF Telomerase-binding protein EST1A (EC 3.1.-.-) SMG6 Canis lupus familiaris (Dog) (Canis familiaris) "negative regulation of telomere capping [GO:1904354]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]" "chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; nucleolus [GO:0005730]" DNA polymerase binding [GO:0070182]; manganese ion binding [GO:0030145]; ribonucleoprotein complex binding [GO:0043021]; RNA endonuclease activity [GO:0004521]; telomerase RNA binding [GO:0070034]; telomeric DNA binding [GO:0042162] SNGKENR 3.430000067 0.267449601 803.3953292 15.25989 13.63209 15.31273 15.42843 15.09105 A0A8I3NDQ9 A0A8I3NDQ9_CANLF Tenascin N TNN Canis lupus familiaris (Dog) (Canis familiaris) axonogenesis [GO:0007409]; cell-matrix adhesion [GO:0007160]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoblast proliferation [GO:0033689]; osteoblast development [GO:0002076]; positive regulation of neuron projection development [GO:0010976]; positive regulation of sprouting angiogenesis [GO:1903672]; regulation of bone development [GO:1903010]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of smooth muscle tissue development [GO:1905899] CA3 pyramidal cell dendrite [GO:0097442]; cell surface [GO:0009986]; hippocampal mossy fiber expansion [GO:1990026]; neuronal cell body [GO:0043025]; tenascin complex [GO:0090733] identical protein binding [GO:0042802]; integrin binding [GO:0005178] YTSADGDTRDMAVPK 2 0.515191629 1642.126211 19.35502 0 19.82817 22.14664 20.918 A0A8C0NKG1 A0A8C0NKG1_CANLF Teneurin transmembrane protein 2 TENM2 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cell projection [GO:0042995]; plasma membrane [GO:0005886] IGPLVDK 5.039999962 0.269431566 742.3402439 19.40211 16.91831 17.02439 0 16.15766 A0A8I3PL66 A0A8I3PL66_CANLF Tensin 2 TNS2 Canis lupus familiaris (Dog) (Canis familiaris) cellular homeostasis [GO:0019725]; collagen metabolic process [GO:0032963]; kidney development [GO:0001822]; multicellular organism growth [GO:0035264]; multicellular organismal-level homeostasis [GO:0048871]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of insulin receptor signaling pathway [GO:0046627]; response to muscle activity [GO:0014850] focal adhesion [GO:0005925] identical protein binding [GO:0042802]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; protein tyrosine phosphatase activity [GO:0004725] KFCEDK 2.170000076 0.279221582 827.1082321 15.35959 15.25795 16.53094 13.63399 16.32128 A0A8C0SV87 A0A8C0SV87_CANLF Testis specific 10 TSGA10 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] EKTISGMK 3.190000057 0.356580691 909.6562135 17.66155 14.53004 16.85903 15.76268 14.41715 A0A8C0PJB0 A0A8C0PJB0_CANLF Tetraspanin CD9 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; cell population proliferation [GO:0008283]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; glial cell migration [GO:0008347]; myoblast fusion involved in skeletal muscle regeneration [GO:0014905]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of platelet aggregation [GO:0090331]; paranodal junction assembly [GO:0030913]; receptor internalization [GO:0031623]; regulation of macrophage migration [GO:1905521]; sperm-egg recognition [GO:0035036] external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; protein-containing complex [GO:0032991] integrin binding [GO:0005178] MPVKGGTK 2.950000048 0.249768738 832.4982239 15.10833 0 15.63801 16.52794 16.47176 A0A8C0TR32 A0A8C0TR32_CANLF Tetraspanin TSPAN11 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] TVVVRCGQR 21.42000008 0.559797757 1074.900348 18.9663 14.55952 16.28406 14.42683 15.10656 A0A8C0M6E2 A0A8C0M6E2_CANLF Tetraspanin Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GVLSDLTK 17.59000015 0.353259999 832.7850863 17.81671 18.9112 16.34264 23.24308 17.65117 A0A8C0M118 A0A8C0M118_CANLF Tetratricopeptide repeat domain 22 TTC22 Canis lupus familiaris (Dog) (Canis familiaris) MGLGGMPDR 7.119999886 0.271137248 949.856292 13.15255 15.01805 15.35867 16.95154 15.72974 A0A8C0MUK6 A0A8C0MUK6_CANLF "Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2" TANC2 Canis lupus familiaris (Dog) (Canis familiaris) synapse [GO:0045202] MLLTGGK 20.01000023 0.451086977 719.8650586 15.42666 15.50978 18.12554 16.43672 14.6075 A0A8P0S8Y7 A0A8P0S8Y7_CANLF Threonylcarbamoyl-AMP synthase (EC 2.7.7.87) YRDC Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] double-stranded RNA binding [GO:0003725]; transferase activity [GO:0016740] KGGGGGGGEQR 11.76000023 0.186468051 960.7069389 16.30588 10.58439 15.3668 16.00775 14.57668 A0A8C0QLV6 A0A8C0QLV6_CANLF Thromboxane-A synthase (EC 4.2.1.152) (EC 5.3.99.5) (Cytochrome P450 5A1) TBXAS1 Canis lupus familiaris (Dog) (Canis familiaris) prostaglandin biosynthetic process [GO:0001516] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; isomerase activity [GO:0016853]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" APGDPFVK 3.579999924 0.239392003 830.4117204 15.41542 15.14087 12.39705 0 17.26535 A0A8C0RNT4 A0A8C0RNT4_CANLF Thyroid hormone receptor interactor 10 TRIP10 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897]; signal transduction [GO:0007165] cell cortex [GO:0005938]; cytoskeleton [GO:0005856]; lysosome [GO:0005764]; plasma membrane [GO:0005886] SHMAEESK 8.130000114 1.22E-13 919.1163139 12.59531 12.24152 15.22728 12.84093 13.00836 A0A8C0QH22 A0A8C0QH22_CANLF Thyrotropin-releasing hormone receptor (Thyroliberin receptor) LOC485909 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] thyrotropin-releasing hormone receptor activity [GO:0004997] AQTLCTVAR 2.599999905 0.23747694 1019.565602 15.63125 8.9364 14.49026 15.55101 13.79722 A0A8C0N1C2 A0A8C0N1C2_CANLF Tigger transposable element derived 4 TIGD4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] LPLLVIGK 9.229999542 0.083213324 851.3379878 15.9106 19.41985 16.66184 18.63193 17.35232 O62683 ZO3_CANLF Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) TJP3 ZO3 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; establishment of endothelial intestinal barrier [GO:0090557]; positive regulation of blood-brain barrier permeability [GO:1905605]; protein localization to cell-cell junction [GO:0150105] bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; tight junction [GO:0070160] cell adhesion molecule binding [GO:0050839] NEDIFR 15.65999985 0.313164977 794.759112 17.19369 16.80202 0 20.93153 18.95852 A0A8I3PE72 A0A8I3PE72_CANLF Titin TTN Canis lupus familiaris (Dog) (Canis familiaris) intracellular organelle [GO:0043229] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] ESNKDDFGK 3.190000057 0 1039.09125 11.69578 14.23959 12.78334 12.31504 13.90578 A0A8C0YUA4 A0A8C0YUA4_CANLF Tr-type G domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746] KDGNAR 8.68999958 0.325710332 660.8379365 14.94819 15.15706 15.43866 14.39896 16.87966 A0A8C0M9Y4 A0A8C0M9Y4_CANLF Trafficking protein particle complex subunit 6A TRAPPC6A Canis lupus familiaris (Dog) (Canis familiaris) Golgi vesicle transport [GO:0048193] Golgi apparatus [GO:0005794] GAGPRQVR 4.119999886 0.23944123 840.560879 13.50474 12.3286 12.98486 13.82494 13.59146 A0A8C0MFJ8 A0A8C0MFJ8_CANLF Transaldolase (EC 2.2.1.2) TALDO1 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; pentose-phosphate shunt [GO:0006098] cytoplasm [GO:0005737] transaldolase activity [GO:0004801] AGPHVQCR 7.610000134 0.244650938 925.2161773 18.47586 16.41584 16.50989 15.34358 16.76334 A0A8C0MAF8 A0A8C0MAF8_CANLF Transaldolase (EC 2.2.1.2) TALDO1 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; pentose-phosphate shunt [GO:0006098] cytoplasm [GO:0005737] transaldolase activity [GO:0004801] FAADAVK 3.609999895 0.40097141 722.112479 16.16515 15.47335 16.89148 15.81227 15.26658 A0A8C0LZL4 A0A8C0LZL4_CANLF Transcription elongation factor TCEA3 Canis lupus familiaris (Dog) (Canis familiaris) transcription elongation by RNA polymerase II [GO:0006368] nucleus [GO:0005634] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] AEEPKER 3.569999933 0.295410759 858.8853713 16.31987 12.97094 14.50794 13.45302 15.07474 A0A8C0YUA8 A0A8C0YUA8_CANLF Transcription factor 4 TCF4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; nucleus [GO:0005634] DNA binding [GO:0003677]; protein dimerization activity [GO:0046983] RCSMNFR 6.090000153 0.149765949 983.6791965 15.66183 15.31652 12.06886 15.931 14.17583 A0A8C0PYR1 A0A8C0PYR1_CANLF Transcriptional adapter TADA2A Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; mitotic cell cycle [GO:0000278]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of embryonic development [GO:0045995]; regulation of histone acetylation [GO:0035065]; regulation of protein phosphorylation [GO:0001932]; regulation of protein stability [GO:0031647]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043] ATAC complex [GO:0140672]; mitotic spindle [GO:0072686]; nucleus [GO:0005634] transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270] EGYITKA 2.220000029 1.23E-13 780.5024314 0 16.21122 14.52041 11.39747 12.63536 A0A8C0RBL2 A0A8C0RBL2_CANLF Transcriptional adapter TADA2B Canis lupus familiaris (Dog) (Canis familiaris) regulation of histone acetylation [GO:0035065]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634]; SAGA complex [GO:0000124] transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270] QGIPSKSR 3.660000086 1.22E-13 872.596506 16.01823 15.10691 14.42446 12.96639 12.52145 A0A8I3Q6A6 A0A8I3Q6A6_CANLF Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked nuclear protein) ATRX Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to hydroxyurea [GO:0072711]; chromosome organization involved in meiotic cell cycle [GO:0070192]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; forebrain development [GO:0030900]; meiotic spindle organization [GO:0000212]; multicellular organism growth [GO:0035264]; negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric [GO:1904908]; nucleosome assembly [GO:0006334]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic forelimb morphogenesis [GO:0035128]; protein localization to chromosome, telomeric region [GO:0070198]; replication fork processing [GO:0031297]; seminiferous tubule development [GO:0072520]; Sertoli cell development [GO:0060009]; spermatogenesis [GO:0007283]; subtelomeric heterochromatin formation [GO:0031509]; transcription by RNA polymerase II [GO:0006366]" "chromosome, subtelomeric region [GO:0099115]; condensed chromosome, centromeric region [GO:0000779]; nuclear chromosome [GO:0000228]; pericentric heterochromatin [GO:0005721]; PML body [GO:0016605]" ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; chromo shadow domain binding [GO:0070087]; DNA binding [GO:0003677]; DNA translocase activity [GO:0015616]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064] GKAGAK 4.429999828 0 530.7159729 10.54944 13.48275 0 14.85187 12.29252 A0A8C0M9Z7 A0A8C0M9Z7_CANLF Transcriptional repressor GATA binding 1 TRPS1 Canis lupus familiaris (Dog) (Canis familiaris) skeletal system development [GO:0001501] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein domain specific binding [GO:0019904]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]" SHSAQQPVLVSQTLDIHKR 6.690000057 0.272842606 2143.00337 19.03653 0 0 20.08586 18.47225 A0A8C0S5L2 A0A8C0S5L2_CANLF Transformation/transcription domain associated protein TRRAP Canis lupus familiaris (Dog) (Canis familiaris) regulation of macromolecule metabolic process [GO:0060255]; regulation of nitrogen compound metabolic process [GO:0051171]; regulation of primary metabolic process [GO:0080090] CFAQPNFKVDGILK 6.130000114 0.088781511 1635.897334 15.6743 0 0 17.14123 0 A0A8C0M4W6 A0A8C0M4W6_CANLF Transforming acidic coiled-coil-containing protein C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mitotic spindle organization [GO:0007052] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] DPQTHR 8.079999924 0.326678454 752.2027836 16.32271 14.63632 16.0762 17.03525 16.34105 A0A8C0MMB3 A0A8C0MMB3_CANLF Transient receptor potential cation channel subfamily A member 1 TRPA1 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to organic substance [GO:0071310]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; intracellular calcium ion homeostasis [GO:0006874]; protein homotetramerization [GO:0051289]; response to cold [GO:0009409]; response to organic cyclic compound [GO:0014070]; response to pain [GO:0048265]; response to xenobiotic stimulus [GO:0009410]; thermoception [GO:0050955] plasma membrane [GO:0005886]; stereocilium bundle [GO:0032421] calcium-release channel activity [GO:0015278]; identical protein binding [GO:0042802]; temperature-gated cation channel activity [GO:0097604] DNSEALQILLNK 9.380000114 0.009367623 1357.820322 0 13.92337 15.60402 10.57934 12.46592 A0A8C0Z5K3 A0A8C0Z5K3_CANLF Transient receptor potential cation channel subfamily V member 4 TRPV4 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] lipid transfer activity [GO:0120013] ADISGNITMR 6.829999924 0.064318935 1092.4814 13.60768 14.38412 13.58977 16.21492 14.04187 A0A8I3PAV3 A0A8I3PAV3_CANLF Transient receptor potential cation channel subfamily V member 4 TRPV4 Canis lupus familiaris (Dog) (Canis familiaris) blood vessel endothelial cell delamination [GO:0097497]; calcium ion import [GO:0070509]; calcium ion import into cytosol [GO:1902656]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cell-cell junction assembly [GO:0007043]; cellular hypotonic salinity response [GO:0071477]; cellular response to heat [GO:0034605]; diet induced thermogenesis [GO:0002024]; glucose homeostasis [GO:0042593]; hyperosmotic salinity response [GO:0042538]; intracellular calcium ion homeostasis [GO:0006874]; multicellular organismal-level water homeostasis [GO:0050891]; negative regulation of brown fat cell differentiation [GO:1903444]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osmosensory signaling pathway [GO:0007231]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]; positive regulation of chemokine (C-X-C motif) ligand 1 production [GO:2000340]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage inflammatory protein 1 alpha production [GO:0071642]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of vascular permeability [GO:0043117]; regulation of aerobic respiration [GO:1903715]; regulation of response to osmotic stress [GO:0047484]; response to insulin [GO:0032868]; vasopressin secretion [GO:0030103] adherens junction [GO:0005912]; cilium [GO:0005929]; plasma membrane [GO:0005886] "calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; osmosensor activity [GO:0005034]; protein kinase binding [GO:0019901]; SH2 domain binding [GO:0042169]; stretch-activated, monoatomic cation-selective, calcium channel activity [GO:0015275]" HHPSDNK 8.850000381 0.328908827 833.3142686 16.38927 0 12.69906 15.35859 16.23127 A0A8I3S761 A0A8I3S761_CANLF Translocation associated membrane protein 1 like 1 TRAM1L1 Canis lupus familiaris (Dog) (Canis familiaris) "SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]" membrane [GO:0016020] VGSAAMAFRK 9.760000229 0 1037.312152 14.40249 14.47283 13.77503 15.73061 14.33537 A0A8C0SZZ2 A0A8C0SZZ2_CANLF Transmembrane and coiled-coil domain family 2 TMCC2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SKPPDLK 6.929999828 0.068087407 785.478383 13.99583 15.8001 14.15473 14.53572 15.00809 A0A8C0PH45 A0A8C0PH45_CANLF Transmembrane protease serine (EC 3.4.21.-) Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular region [GO:0005576]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] MYRPAVVK 4.639999866 0.317563245 963.7469161 15.79953 14.28138 0 13.84323 14.59048 A0A455R0B8 A0A455R0B8_CANLF "Transmembrane protease, serine 2" TMPRSS2 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular region [GO:0005576]; membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] GGVDSCQGDSGGPLVTLK 6.070000172 0 1748.019389 0 13.5123 0 0 14.91128 A0A8C0NQR3 A0A8C0NQR3_CANLF Transmembrane protein 117 TMEM117 Canis lupus familiaris (Dog) (Canis familiaris) intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] MGKDFR 6.150000095 0.399192296 752.6806304 17.6383 15.7357 16.04227 16.95007 15.82479 A0A8I3N6I3 A0A8I3N6I3_CANLF Transmembrane protein 126B TMEM126B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CPEGRR 12.47000027 0.040884543 773.3038492 17.82946 18.38353 17.53608 19.53213 18.90011 A0A8C0MW44 A0A8C0MW44_CANLF Transmembrane protein 161B TMEM161B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DLSAAPCK 2.049999952 1.23E-13 862.3237239 0 14.78124 15.32422 15.64903 16.2286 A0A8C0RP84 A0A8C0RP84_CANLF Transmembrane protein 169 TMEM169 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EITPEDR 3.569999933 0.079478515 859.5259583 15.84619 19.47363 17.9039 17.09467 19.10652 A0A8C0Q6Y9 A0A8C0Q6Y9_CANLF Transmembrane protein 17 TMEM17 Canis lupus familiaris (Dog) (Canis familiaris) non-motile cilium assembly [GO:1905515]; smoothened signaling pathway [GO:0007224] ciliary membrane [GO:0060170]; MKS complex [GO:0036038] QRLGNFSR 8.180000305 1.22E-13 978.5935591 0 13.18374 9.324004 14.72576 13.8278 A0A8P0PH92 A0A8P0PH92_CANLF Transmembrane protein 191C TMEM191C Canis lupus familiaris (Dog) (Canis familiaris) RGGLSVAPAGR 2.180000067 0.2701969 1039.32327 16.02687 15.17916 14.58342 15.50968 16.80753 A0A8C0LX04 A0A8C0LX04_CANLF Transmembrane protein 240 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GRCLRPR 5.510000229 0.218091854 914.3713156 16.15616 14.84978 17.08357 16.1481 0 A0A8C0MFQ5 A0A8C0MFQ5_CANLF Transmembrane protein 253 TMEM253 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SQSLHYR 7.210000038 0.277754498 889.5366609 16.19992 12.6449 11.47847 15.84068 14.90738 A0A8P0SFD9 A0A8P0SFD9_CANLF Transmembrane protein 54 TMEM54 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] MEQPGLSK 8.050000191 0 890.2073324 12.68386 14.50231 14.59475 14.22905 15.05991 A0A8I3P0T2 A0A8I3P0T2_CANLF Transmembrane protein 59 TMEM59 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of protein localization to plasma membrane [GO:1903077]; positive regulation of autophagy [GO:0010508]; protein glycosylation [GO:0006486] Golgi cis cisterna [GO:0000137]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886] endopeptidase activity [GO:0004175] GSLWVRAQR 2.539999962 0.23792481 1071.547843 13.40802 14.38276 9.038242 9.324402 14.81623 A0A8C0RXY1 A0A8C0RXY1_CANLF Transmembrane protein 9 CACNA1S Canis lupus familiaris (Dog) (Canis familiaris) lysosomal membrane [GO:0005765] QSACAPLLP 3.269999981 0.306742807 956.3300203 13.81784 16.70185 13.71496 16.14796 14.61729 A0A8C0P4V8 A0A8C0P4V8_CANLF Trinucleotide repeat containing adaptor 6B TNRC6B Canis lupus familiaris (Dog) (Canis familiaris) regulation of translation [GO:0006417] cytosol [GO:0005829] RNA binding [GO:0003723] GGNNDSWMNPLAK 3.869999886 2.46E-13 1420.217352 15.03225 15.13135 13.43166 14.85279 14.54967 A0A8P0TCB5 A0A8P0TCB5_CANLF Trinucleotide repeat containing adaptor 6C TNRC6C Canis lupus familiaris (Dog) (Canis familiaris) regulation of translation [GO:0006417] cytosol [GO:0005829] RNA binding [GO:0003723] ASASSQQPAASRYLPR 10.60999966 0 1690.416743 0 0 0 15.52761 13.9848 A0A8C0N1W2 A0A8C0N1W2_CANLF Tripartite motif containing 50 TRIM50 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] cytosol [GO:0005829] identical protein binding [GO:0042802]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] HLDSELR 7.710000038 0.218263481 869.0806835 17.33867 18.20479 16.99279 17.11334 17.27025 A0A8C0RFA6 A0A8C0RFA6_CANLF Tropomodulin 4 TMOD4 Canis lupus familiaris (Dog) (Canis familiaris) pointed-end actin filament capping [GO:0051694] striated muscle thin filament [GO:0005865] tropomyosin binding [GO:0005523] MSSYQK 9.93999958 0.313649695 760.025233 17.05306 17.04886 17.33435 21.3636 17.7909 A0A8C0SD98 A0A8C0SD98_CANLF Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 2) TPH2 Canis lupus familiaris (Dog) (Canis familiaris) aromatic amino acid metabolic process [GO:0009072]; serotonin biosynthetic process [GO:0042427] neuron projection [GO:0043005] iron ion binding [GO:0005506]; tryptophan 5-monooxygenase activity [GO:0004510] NEVGGLVK 6.510000229 0.077347309 814.6057179 12.87627 16.72211 13.21031 13.20303 11.67387 A0A8C0NE29 A0A8C0NE29_CANLF Tubby-like protein TULP1 Canis lupus familiaris (Dog) (Canis familiaris) "dendrite development [GO:0016358]; detection of light stimulus involved in visual perception [GO:0050908]; eye photoreceptor cell development [GO:0042462]; phagocytosis, recognition [GO:0006910]; photoreceptor cell maintenance [GO:0045494]; positive regulation of phagocytosis [GO:0050766]; protein localization to photoreceptor outer segment [GO:1903546]; retina development in camera-type eye [GO:0060041]" axon terminus [GO:0043679]; cytosol [GO:0005829]; extracellular region [GO:0005576]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886] "actin filament binding [GO:0051015]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" IPLPPK 6.75 1.23E-13 663.4123837 14.57863 0 15.34392 16.03549 14.77825 A0A0U5JY34 A0A0U5JY34_CANLF Tumor necrosis factor ligand 7B TNLG7B Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615]; membrane [GO:0016020] cytokine activity [GO:0005125]; tumor necrosis factor receptor binding [GO:0005164] AALIHK 12.84000015 0.434090795 651.8837849 19.33855 16.30385 17.88427 16.1258 16.76574 A0A8C0MZ11 A0A8C0MZ11_CANLF Tumor protein D52 Canis lupus familiaris (Dog) (Canis familiaris) DGAMDRGEQGLLR 6.480000019 0 1418.000585 14.95519 0 15.36636 15.20755 0 A0A8C0MLN8 A0A8C0MLN8_CANLF Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) PTPN13 Canis lupus familiaris (Dog) (Canis familiaris) dephosphorylation [GO:0016311] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] protein tyrosine phosphatase activity [GO:0004725] RSAVSTPK 10.21000004 0.308882374 846.2328034 14.38435 13.00375 15.10987 13.60654 13.70278 A0A8I3PXV2 A0A8I3PXV2_CANLF Tyrosine-protein phosphatase non-receptor type (EC 3.1.3.48) PTPN1 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; dephosphorylation [GO:0016311]; insulin receptor recycling [GO:0038020]; insulin receptor signaling pathway [GO:0008286]; IRE1-mediated unfolded protein response [GO:0036498]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; platelet-derived growth factor receptor-beta signaling pathway [GO:0035791]; positive regulation of receptor catabolic process [GO:2000646]; regulation of endocytosis [GO:0030100]; regulation of hepatocyte growth factor receptor signaling pathway [GO:1902202]; regulation of intracellular protein transport [GO:0033157] cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; early endosome [GO:0005769]; endosome lumen [GO:0031904]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; sorting endosome [GO:0097443] ephrin receptor binding [GO:0046875]; protein tyrosine phosphatase activity [GO:0004725]; receptor tyrosine kinase binding [GO:0030971]; zinc ion binding [GO:0008270] KVLLEMR 20.95000076 0.277821407 887.7806191 17.41356 17.85172 18.2138 16.09314 18.45062 A0A8C0PVZ0 A0A8C0PVZ0_CANLF Tyrosyl-DNA phosphodiesterase 1 TDP1 Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair [GO:0006302]; single strand break repair [GO:0000012] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] 3'-tyrosyl-DNA phosphodiesterase activity [GO:0017005]; double-stranded DNA binding [GO:0003690]; nuclease activity [GO:0004518]; single-stranded DNA binding [GO:0003697] FFSGSK 2.319999933 0.204798096 673.2500182 15.79517 16.26913 15.61651 13.44416 16.54696 A0A8C0NIR1 A0A8C0NIR1_CANLF U1 small nuclear ribonucleoprotein 70 kDa SNRNP70 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]" nuclear speck [GO:0016607]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685] U1 snRNA binding [GO:0030619] VLVDVERGR 3.039999962 2.46E-13 1043.704911 14.38063 10.84467 17.38937 0 15.48347 A0A8C0QDU0 A0A8C0QDU0_CANLF U2 snRNP associated SURP domain containing U2SURP Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] nucleus [GO:0005634] RNA binding [GO:0003723] ADKTPGGSQK 3.960000038 0.31947779 989.1655987 16.18299 14.62943 13.73694 14.33757 15.288 A0A8C0M7D0 A0A8C0M7D0_CANLF U3 small nucleolar ribonucleoprotein protein MPP10 Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] Mpp10 complex [GO:0034457]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732] ASLLKDEGK 5.590000153 0.308281213 961.4607042 14.35162 15.2204 14.92946 0 13.77413 A0A8C0MGA6 A0A8C0MGA6_CANLF U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) PRPF3 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" spliceosomal complex [GO:0005681]; U4/U6 x U5 tri-snRNP complex [GO:0046540] VSIAPSQR 5.059999943 0.297665406 856.7133503 15.90544 14.60035 0 15.65123 13.19566 A0A8C0MIZ2 A0A8C0MIZ2_CANLF UBA domain-containing protein UBAP2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] IPPASK 1.429999948 0.200075824 611.5705576 19.10932 17.38218 17.19454 17.53224 16.37109 A0A8C0NUR8 A0A8C0NUR8_CANLF UBA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869] AEVKTPK 4.730000019 0.317379966 771.8888954 18.58547 15.15444 15.38755 15.65752 14.82194 A0A8C0SIS6 A0A8C0SIS6_CANLF UBA like domain containing 1 UBALD1 Canis lupus familiaris (Dog) (Canis familiaris) SVNMDELK 4.539999962 0.285857272 952.9871591 15.96298 15.63596 14.93131 15.37462 15.37121 A0A8C0TUK4 A0A8C0TUK4_CANLF UBX domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DLHFDR 3.730000019 0.111155311 801.3596034 17.43463 16.45429 13.9785 15.9229 15.15031 A0A8C0S7H0 A0A8C0S7H0_CANLF UDP-N-acetylglucosamine pyrophosphorylase 1 Canis lupus familiaris (Dog) (Canis familiaris) uridylyltransferase activity [GO:0070569] GARPSRGR 7.96999979 0.219152664 857.9691589 16.83069 15.12506 0 14.83499 0 A0A8C0N2Z6 A0A8C0N2Z6_CANLF URB1 ribosome biogenesis homolog URB1 Canis lupus familiaris (Dog) (Canis familiaris) LGSQEPPK 2.25999999 0.320310918 855.327691 14.79555 15.77881 15.77326 15.97306 16.5391 A0A8C0N454 A0A8C0N454_CANLF UTP20 small subunit processome component UTP20 Canis lupus familiaris (Dog) (Canis familiaris) ELQTTLVR 4.380000114 0.168694566 960.5285149 17.75916 16.59649 16.6427 16.84619 0 A0A8C0NYF5 A0A8C0NYF5_CANLF UbiA prenyltransferase domain-containing protein 1 (EC 2.5.1.39) UBIAD1 Canis lupus familiaris (Dog) (Canis familiaris) menaquinone biosynthetic process [GO:0009234]; ubiquinone biosynthetic process [GO:0006744]; vitamin K biosynthetic process [GO:0042371] endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; nucleus [GO:0005634] antioxidant activity [GO:0016209]; prenyltransferase activity [GO:0004659] DMESDR 22.59000015 0.160015228 751.2741703 19.91279 15.60763 16.80143 15.61931 14.33728 A0A8C0NMA6 A0A8C0NMA6_CANLF Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-specific-processing protease 16) USP16 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; DNA damage response [GO:0006974]; histone deubiquitination [GO:0016578]; mitotic nuclear division [GO:0140014]; monoubiquitinated protein deubiquitination [GO:0035520]; positive regulation of ribosome biogenesis [GO:0090070]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translational elongation [GO:0045901]; protein homotetramerization [GO:0051289]; proteolysis [GO:0006508]; regulation of cell cycle [GO:0051726] cytoplasm [GO:0005737]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; histone binding [GO:0042393]; histone H2A deubiquitinase activity [GO:0140950]; ribosomal small subunit binding [GO:0043024]; transcription coactivator activity [GO:0003713]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270] KQAGITTPK 6.320000172 0.187311702 943.5564098 17.21805 14.44628 15.10618 13.90632 15.48245 A0A8I3S6H8 A0A8I3S6H8_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) USP20 Canis lupus familiaris (Dog) (Canis familiaris) antiviral innate immune response [GO:0140374]; endocytosis [GO:0006897]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; positive regulation of autophagy [GO:0010508]; proteolysis [GO:0006508]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] centrosome [GO:0005813]; perinuclear region of cytoplasm [GO:0048471] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; G protein-coupled receptor binding [GO:0001664]; zinc ion binding [GO:0008270] KPALCKSYQK 10.52999973 0.274510772 1222.09152 16.0565 17.22675 15.70083 0 18.2464 A0A8C0Q0L3 A0A8C0Q0L3_CANLF Ubiquitin specific peptidase 36 USP36 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of macroautophagy [GO:0016242]; nucleolus organization [GO:0007000]; protein stabilization [GO:0050821]; regulation of rRNA processing [GO:2000232] cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730] cysteine-type deubiquitinase activity [GO:0004843]; histone H2B deubiquitinase activity [GO:0140936]; K48-linked deubiquitinase activity [GO:1990380] ALELFVKPDVLSGENAYMCAK 7.400000095 0 2371.617383 16.97105 13.51979 0 13.84513 9.115413 A0A8I3Q9C4 A0A8I3Q9C4_CANLF Ubiquitin specific peptidase 53 USP53 Canis lupus familiaris (Dog) (Canis familiaris) action potential [GO:0001508]; epithelial cell apoptotic process [GO:1904019]; outer hair cell apoptotic process [GO:1905584]; response to auditory stimulus [GO:0010996]; sensory perception of sound [GO:0007605] bicellular tight junction [GO:0005923] cysteine-type deubiquitinase activity [GO:0004843] GSTYSGSSK 2.369999886 0.193462446 872.3683472 17.09084 16.38491 15.84992 15.22292 16.00505 A0A8I3PNU1 A0A8I3PNU1_CANLF Ubiquitin specific peptidase 8 USP8 Canis lupus familiaris (Dog) (Canis familiaris) mitotic cytokinesis [GO:0000281]; negative regulation of lysosomal protein catabolic process [GO:1905166]; positive regulation of amyloid fibril formation [GO:1905908]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein metabolic process [GO:0019538]; regulation of protein localization [GO:0032880]; regulation of protein stability [GO:0031647] cytosol [GO:0005829]; early endosome [GO:0005769]; midbody [GO:0030496] cysteine-type deubiquitinase activity [GO:0004843]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578] SNLLGHKGEVAEEFGIIMK 5.610000134 0.309950329 2087.496161 17.6121 15.01304 17.92147 0 0 A0A8C0PLG5 A0A8C0PLG5_CANLF Ubiquitin-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] GGMQIFMK 18.38999939 0.253356206 927.6668882 14.30094 14.10149 13.19274 11.91751 13.38844 P63050 RL40_CANLF Ubiquitin-ribosomal protein eL40 fusion protein (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40 (60S ribosomal protein L40) (CEP52)] UBA52 UBCEP2 B9 Canis lupus familiaris (Dog) (Canis familiaris) modification-dependent protein catabolic process [GO:0019941]; protein ubiquitination [GO:0016567]; translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] protein tag activity [GO:0031386]; structural constituent of ribosome [GO:0003735]; ubiquitin protein ligase binding [GO:0031625] TLSDYNIQK 2.019999981 0.179361716 1081.206856 12.3039 15.13525 11.12595 15.73445 12.62384 A0A8I3PP72 A0A8I3PP72_CANLF Ufm1-specific protease 2 UFSP2 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146] endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] deUFMylase activity [GO:0071567] MDILFR 14.43000031 0.288856037 810.3645716 17.3728 15.65174 15.39081 16.52735 14.86452 A0A8C0MK01 A0A8C0MK01_CANLF UmuC domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DNA biosynthetic process [GO:0071897]; DNA repair [GO:0006281] damaged DNA binding [GO:0003684] KLMNVR 4.289999962 0.257534896 775.1808259 13.11583 14.3382 14.93036 15.79858 14.97864 A0A8I3NCE8 A0A8I3NCE8_CANLF "Unc-93 homolog B1, TLR signaling regulator" UNC93B1 Canis lupus familiaris (Dog) (Canis familiaris) antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; cell morphogenesis [GO:0000902]; intracellular protein transport [GO:0006886]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; T cell antigen processing and presentation [GO:0002457]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 7 signaling pathway [GO:0034154]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224] early phagosome [GO:0032009]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; lysosome [GO:0005764]; membrane [GO:0016020] Toll-like receptor binding [GO:0035325] HVRDFR 4.699999809 0.352694006 829.0902584 15.87057 13.98937 16.2119 16.37698 15.745 A0A8I3Q2Y1 A0A8I3Q2Y1_CANLF Uncharacterized protein CHAMP1 Canis lupus familiaris (Dog) (Canis familiaris) attachment of mitotic spindle microtubules to kinetochore [GO:0051315] MIFYQK 7.489999771 0.284041636 831.2566891 16.4187 14.69946 13.86219 17.15209 15.90617 A0A8I3S1A7 A0A8I3S1A7_CANLF Uncharacterized protein DIAPH3 Canis lupus familiaris (Dog) (Canis familiaris) actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; actin filament polymerization [GO:0030041]; actin nucleation [GO:0045010]; autophagosome-lysosome fusion [GO:0061909]; cell projection organization [GO:0030030]; chromosome segregation [GO:0007059]; endosomal transport [GO:0016197]; erythrocyte enucleation [GO:0043131]; establishment of cell polarity [GO:0030010]; gene expression [GO:0010467]; head development [GO:0060322]; in utero embryonic development [GO:0001701]; inner ear receptor cell differentiation [GO:0060113]; integrin-mediated signaling pathway [GO:0007229]; macrophage differentiation [GO:0030225]; microtubule polymerization [GO:0046785]; negative regulation of microtubule depolymerization [GO:0007026]; podosome assembly [GO:0071800]; protein-containing complex remodeling [GO:0034367]; sensory perception of sound [GO:0007605] actin filament bundle [GO:0032432]; cleavage furrow [GO:0032154]; ESCRT I complex [GO:0000813]; filamentous actin [GO:0031941]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; ribbon synapse [GO:0097470]; spindle pole [GO:0000922]; stereocilia tip-link density [GO:1990427] actin binding [GO:0003779]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267] LLELVLLMGNYMNAGSR 3.269999981 2.43E-13 1926.982114 15.04631 14.215 11.52777 16.89619 15.11726 A0A8I3MZR8 A0A8I3MZR8_CANLF Uncharacterized protein GAS7 Canis lupus familiaris (Dog) (Canis familiaris) ARAAPAPAGPR 5.320000172 0.226710687 1034.274416 13.48494 16.10681 13.8565 13.01687 0 A0A8I3P1N0 A0A8I3P1N0_CANLF Uncharacterized protein OGFR Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] opioid growth factor receptor activity [GO:0140625] RGPMSLLGR 6.179999828 0.065926067 986.1384738 12.98665 13.94381 14.35755 13.75433 13.67266 A0A8I3ND03 A0A8I3ND03_CANLF Uncharacterized protein SUGT1 Canis lupus familiaris (Dog) (Canis familiaris) kinetochore assembly [GO:0051382]; skeletal muscle satellite cell proliferation [GO:0014841]; spindle organization [GO:0007051] cytoplasm [GO:0005737]; kinetochore [GO:0000776] lncRNA binding [GO:0106222]; protein-folding chaperone binding [GO:0051087] LVGEIK 4.429999828 0.08310713 657.2662369 15.57781 13.8985 14.57892 15.45443 15.00502 A0A8I3PSM7 A0A8I3PSM7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) CAPTVGR 5.230000019 0.040807192 759.4628559 15.124 12.48159 14.51399 16.01 14.8828 A0A8I3NKK6 A0A8I3NKK6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GLTSGRSQR 2.119999886 0.136505918 960.7593478 13.31869 13.84323 14.59779 16.57356 15.69835 A0A8C0S2T6 A0A8C0S2T6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) HGGGGGEKPRK 2.75 0.295316755 1078.546583 15.06457 15.09858 17.40891 14.54535 14.15094 A0A8C0P5Q9 A0A8C0P5Q9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] UDP-glycosyltransferase activity [GO:0008194] MVLLSGKCISTCVSK 1.639999986 2.46E-13 1697.984169 15.36141 16.60616 16.47207 16.99458 13.68732 A0A8C0TQ26 A0A8C0TQ26_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) RGAGGSPR 7.039999962 0.219369326 758.1973254 17.03495 14.57362 16.40755 15.30029 15.15257 A0A8P0PRF8 A0A8P0PRF8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] SHDSLYIR 1.710000038 0.32027418 991.1086363 17.14896 17.24421 16.40677 20.03338 17.08069 A0A8C0TU70 A0A8C0TU70_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DVEDTPLENK 8.140000343 0.104682033 1160.634628 12.32744 13.81049 17.26103 15.15702 11.77833 A0A8I3RTI6 A0A8I3RTI6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) IKMDER 7.710000038 0.248233159 806.6874742 19.14507 20.12928 17.87401 18.31819 19.02687 A0A8I3MLM7 A0A8I3MLM7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GTSTGSMSK 18.71999931 0.364998344 870.830763 16.07395 15.66331 16.85964 15.25753 16.25603 A0A8C0P3F3 A0A8C0P3F3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GVEMESR 6.860000134 0.304822073 806.7121505 15.13704 15.69966 15.02628 17.15962 15.46614 A0A8C0QCN2 A0A8C0QCN2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] membrane [GO:0016020] MMVALK 3.980000019 0.356265325 709.7970776 16.33351 15.79495 12.7167 16.2103 15.42666 A0A8C0YVG2 A0A8C0YVG2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) NSPFSR 1.220000029 0.414586293 708.3142269 16.04239 16.27532 17.94481 15.80914 16.76024 A0A8C0TWV7 A0A8C0TWV7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; cytoskeletal protein binding [GO:0008092]; phospholipase inhibitor activity [GO:0004859] YALNNEMAIK 1.129999995 0.054132339 1167.301547 14.97387 15.09044 12.93789 15.30332 15.77662 A0A8C0P612 A0A8C0P612_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) VLISTTQR 12 0.169001995 918.420323 15.49935 13.86448 14.68885 13.14383 14.35852 A0A8C0PFZ7 A0A8C0PFZ7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) EVMEAGGPVLWGR 9.449999809 0 1416.034216 0 14.44155 15.70838 12.80509 0 A0A8C0QEV8 A0A8C0QEV8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) KPSVSAR 4.46999979 0.035032362 744.2743544 14.31177 14.95565 16.63433 14.25875 0 A0A8C0N362 A0A8C0N362_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] membrane [GO:0016020] metal ion binding [GO:0046872] NHQGIHIG 3.430000067 0.358786537 875.9123426 15.43426 14.84177 15.70938 17.49657 15.95615 A0A8C0SMD1 A0A8C0SMD1_CANLF Upstream stimulatory factor 1 USF1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] protein dimerization activity [GO:0046983] GGILSK 4.920000076 0.130252514 575.3919637 14.20059 15.59055 14.59696 14.03665 15.70242 A0A8C0P031 A0A8C0P031_CANLF Utrophin UTRN Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; plasma membrane bounded cell projection [GO:0120025]; postsynaptic membrane [GO:0045211] actin binding [GO:0003779]; zinc ion binding [GO:0008270] AWLTEKEEALNK 13.56999969 2.46E-13 1430.808061 15.87633 16.83881 16.18783 17.14551 16.38129 A0A8C0RCC2 A0A8C0RCC2_CANLF V(D)J recombination-activating protein 2 RAG2 Canis lupus familiaris (Dog) (Canis familiaris) B cell homeostatic proliferation [GO:0002358]; B cell lineage commitment [GO:0002326]; chromatin organization [GO:0006325]; defense response to bacterium [GO:0042742]; DN2 thymocyte differentiation [GO:1904155]; organ growth [GO:0035265]; positive regulation of organ growth [GO:0046622]; pre-B cell allelic exclusion [GO:0002331]; T cell lineage commitment [GO:0002360]; V(D)J recombination [GO:0033151] nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; methylated histone binding [GO:0035064]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]" LKPAVFSK 3.599999905 0.346173538 888.6646379 19.96366 15.3002 14.98423 17.72291 16.94838 A0A8C0S097 A0A8C0S097_CANLF V-type proton ATPase subunit a ATP6V0A1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401] "clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; melanosome [GO:0042470]; nuclear speck [GO:0016607]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]" "ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]" EMASGVNTR 2.279999971 0.259326245 965.3778465 15.88349 16.96198 14.1739 14.55294 0 A0A0H4M9N6 A0A0H4M9N6_AHSV4 VP6 VP6 African horse sickness virus 4 (AHSV-4) viral capsid [GO:0019028] structural molecule activity [GO:0005198] RGGSLR 6.929999828 0.21595225 644.8643004 15.00043 12.94306 13.31205 17.01416 12.23022 A0A8C0P0B9 A0A8C0P0B9_CANLF VPS35 endosomal protein-sorting factor-like CCP110 Canis lupus familiaris (Dog) (Canis familiaris) endocytic recycling [GO:0032456] AGTATSAMSEK 9.359999657 0 1068.412757 16.28053 0 14.76267 14.64786 14.00761 A0A8C0M802 A0A8C0M802_CANLF VWFA domain-containing protein CACHD1 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion transport [GO:0006816] membrane [GO:0016020] IYPGSLMDK 6.159999847 0.155421968 1024.10513 15.65959 14.48663 14.08849 14.21046 14.44675 A0A8C0PGN3 A0A8C0PGN3_CANLF VWFA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AMFDSSSGGR 1.559999943 0.118632068 1030.135945 15.2408 13.56376 15.55732 14.51511 14.15978 A0A8C0NXV2 A0A8C0NXV2_CANLF VWFA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LAQEITK 4.179999828 0.360710353 803.7559236 17.18554 16.38869 17.46982 18.85394 18.20631 A0A8C0NEF5 A0A8C0NEF5_CANLF Vacuolar protein sorting 13 homolog B VPS13B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VHGDGAQK 15.40999985 0.174830356 811.3356924 15.76024 14.86249 16.22179 14.54925 14.85722 A0A8C0M5W7 A0A8C0M5W7_CANLF Vacuolar protein sorting-associated protein 41 homolog VPS41 Canis lupus familiaris (Dog) (Canis familiaris) endosomal vesicle fusion [GO:0034058]; intracellular protein transport [GO:0006886]; protein targeting to vacuole [GO:0006623]; vacuolar transport [GO:0007034] clathrin-coated vesicle [GO:0030136]; early endosome membrane [GO:0031901]; Golgi apparatus [GO:0005794]; HOPS complex [GO:0030897]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765] MGNSRSALK 2.50999999 0.035260844 963.3733373 15.72098 14.85633 16.16788 15.14141 14.89842 A0A8C0MVI4 A0A8C0MVI4_CANLF Vascular endothelial growth factor C VEGFC Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; cellular response to leukemia inhibitory factor [GO:1990830]; glial cell proliferation [GO:0014009]; induction of positive chemotaxis [GO:0050930]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell division [GO:0051781]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of lymphangiogenesis [GO:1901492]; positive regulation of mast cell chemotaxis [GO:0060754]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] extracellular space [GO:0005615]; membrane [GO:0016020] chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; vascular endothelial growth factor receptor 3 binding [GO:0043185] NQPLNPGK 9.100000381 0.314165424 867.2122763 14.77911 15.68011 15.75795 17.47241 17.8052 A0A8C0MGW3 A0A8C0MGW3_CANLF Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase (EC 4.2.1.134) Canis lupus familiaris (Dog) (Canis familiaris) fatty acid biosynthetic process [GO:0006633] endoplasmic reticulum membrane [GO:0005789] lyase activity [GO:0016829] LILALGENK 8.539999962 0.307146889 970.7092033 12.9289 0 15.09455 9.493928 0 A0A8I3S0L8 A0A8I3S0L8_CANLF Voltage-dependent T-type calcium channel subunit alpha CACNA1G Canis lupus familiaris (Dog) (Canis familiaris) action potential [GO:0001508]; calcium ion import [GO:0070509]; chemical synaptic transmission [GO:0007268]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of heart rate [GO:0002027]; response to nickel cation [GO:0010045] cytoplasm [GO:0005737]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891] low voltage-gated calcium channel activity [GO:0008332]; metal ion binding [GO:0046872]; scaffold protein binding [GO:0097110] TLRPLR 5.929999828 0.298883431 755.5121072 15.76785 14.8264 16.53261 15.24769 14.75501 A0A8C0N523 A0A8C0N523_CANLF Voltage-dependent anion-selective channel protein 1 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915] membrane raft [GO:0045121]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]; pore complex [GO:0046930] porin activity [GO:0015288]; voltage-gated monoatomic anion channel activity [GO:0008308] VNNSSIK 4.179999828 0.388229065 761.675644 15.5569 15.26418 16.0484 15.43001 0 A0A8C0MSA1 A0A8C0MSA1_CANLF WD repeat and FYVE domain containing 3 WDFY3 Canis lupus familiaris (Dog) (Canis familiaris) aggrephagy [GO:0035973] Atg12-Atg5-Atg16 complex [GO:0034274]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; inclusion body [GO:0016234]; nuclear envelope [GO:0005635]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; PML body [GO:0016605] 1-phosphatidylinositol binding [GO:0005545]; metal ion binding [GO:0046872] RAISYDSK 4.78000021 0.131725268 940.8509504 0 12.52795 14.42129 10.79117 9.750847 A0A8C0M5E9 A0A8C0M5E9_CANLF WD repeat domain 33 WDR33 Canis lupus familiaris (Dog) (Canis familiaris) mRNA 3'-end processing [GO:0031124] nucleus [GO:0005634] SSSLQGMDMASLPPR 8.869999886 0.183677613 1608.605956 14.95799 15.16159 15.61611 16.27982 16.83414 A0A8C0LXZ4 A0A8C0LXZ4_CANLF "WD repeat domain, phosphoinositide interacting 1" Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914] phagophore assembly site [GO:0000407] lipid binding [GO:0008289] LTEPGAGR 3.700000048 0.310534144 800.2599762 16.50727 14.48197 16.15741 16.44079 15.37141 A0A8C0R9Q9 A0A8C0R9Q9_CANLF WH2 domain-containing protein LMOD1 Canis lupus familiaris (Dog) (Canis familiaris) actin nucleation [GO:0045010]; pointed-end actin filament capping [GO:0051694]; positive regulation of actin filament polymerization [GO:0030838] cytosol [GO:0005829]; sarcomere [GO:0030017] actin binding [GO:0003779]; tropomyosin binding [GO:0005523] KDLLGVPPR 3.099999905 1.23E-13 994.5010966 13.77231 15.53013 11.93494 0 12.71335 A0A8C0PVF5 A0A8C0PVF5_CANLF WW and C2 domain containing 1 WWC1 Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of hippo signaling [GO:0035331]; negative regulation of organ growth [GO:0046621]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of MAPK cascade [GO:0043410] cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ruffle membrane [GO:0032587] kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; transcription coactivator activity [GO:0003713] DECPALK 9 0 831.3122519 0 14.7206 15.4525 0 13.78646 A0A8C0MPA5 A0A8C0MPA5_CANLF "WW domain binding protein VOPP1 (EGFR-coamplified and overexpressed protein) (Vesicular, overexpressed in cancer, prosurvival protein 1)" Canis lupus familiaris (Dog) (Canis familiaris) late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765] AGSAGARATR 6.619999886 0.351078256 917.4769382 17.08413 14.73902 15.11989 14.17088 14.6558 A0A8P0TTE3 A0A8P0TTE3_CANLF Whirlin WHRN Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995] LTGLSLPPR 3.940000057 0 954.1063742 11.30854 0 9.895689 15.06378 0 A0A8C0PDU2 A0A8C0PDU2_CANLF ZFP37 zinc finger protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] KPSVAKEHK 6.400000095 0.570360865 1023.436017 15.44137 17.26522 14.86768 14.19392 14.68059 A0A8P0TML0 A0A8P0TML0_CANLF Zinc finger AN1-type containing 4 ZFAND4 Canis lupus familiaris (Dog) (Canis familiaris) VGEFVNMK 3.200000048 0.247873203 921.0318739 15.351 17.48105 15.31834 14.80166 14.96158 A0A8C0M6I1 A0A8C0M6I1_CANLF Zinc finger MYND-type containing 11 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription elongation by RNA polymerase II [GO:0034243] metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] VHGMHPK 2.019999981 0.26472136 805.0479834 15.99762 15.3372 13.96051 15.30447 17.2099 A0A8C0SFQ6 A0A8C0SFQ6_CANLF Zinc finger RANBP2-type containing 3 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; endonuclease activity [GO:0004519]; helicase activity [GO:0004386]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] ILLPIVQK 8.449999809 0.055284947 922.7081908 18.27208 19.35938 20.5162 18.00528 19.56959 A0A8I3N764 A0A8I3N764_CANLF Zinc finger ZZ-type containing 3 ZZZ3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043] ATAC complex [GO:0140672]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] histone reader activity [GO:0140566]; lysine-acetylated histone binding [GO:0070577]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270] RGLSSSEK 8.020000458 0.160626774 863.6397124 13.54625 14.02548 15.46862 12.14328 16.60163 A0A8C0Q585 A0A8C0Q585_CANLF Zinc finger and BTB domain containing 38 ZBTB38 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] MTVMSLSR 8.550000191 0.04058824 939.8833652 13.13346 13.72606 13.44656 16.41401 15.52738 A0A8I3NXU6 A0A8I3NXU6_CANLF Zinc finger and SCAN domain containing 26 NKAPL Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] LKNPDQAK 8.079999924 0.244622111 913.7804532 9.928868 17.68871 14.66622 14.24257 14.40462 A0A8C0RRT8 A0A8C0RRT8_CANLF Zinc finger protein 177 LOC484969 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] DNA binding [GO:0003677]; metal ion binding [GO:0046872] TLTGEK 4.920000076 0.280762285 648.67458 17.00908 15.24005 13.65211 14.77576 16.14899 A0A8C0RB00 A0A8C0RB00_CANLF Zinc finger protein 18 ZNF18 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] VHTGEKPYKCSR 4.079999924 0 1460.619453 15.34477 16.29682 13.79968 11.22986 13.24948 A0A8C0N900 A0A8C0N900_CANLF Zinc finger protein 275 ZNF275 Canis lupus familiaris (Dog) (Canis familiaris) RSSELTK 10.67000008 0.288943245 819.3815785 22.2909 22.60682 20.98419 23.86453 21.71403 A0A8C0NHE7 A0A8C0NHE7_CANLF Zinc finger protein 316 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] metal ion binding [GO:0046872] SFSQSSALAR 3.289999962 0.088237404 1054.278202 15.0918 14.39702 15.69 15.94791 16.25916 A0A8C0LSA3 A0A8C0LSA3_CANLF Zinc finger protein 324A LOC119870868 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] metal ion binding [GO:0046872] GAVLLSHR 3.029999971 0.20726351 852.9361946 17.58781 17.36829 0 16.69201 17.06732 A0A8C0TF47 A0A8C0TF47_CANLF Zinc finger protein 34 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] DNA binding [GO:0003677]; metal ion binding [GO:0046872] IPLGKK 3.150000095 0.171790757 655.2728443 17.30706 15.2064 15.44603 13.85185 15.44901 A0A8C0MH04 A0A8C0MH04_CANLF Zinc finger protein 385B ZNF385B Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] MVSSKDSAK 7.699999809 0.150891841 951.3115748 13.78109 13.39271 16.53217 14.94862 14.94173 A0A8C0MMH6 A0A8C0MMH6_CANLF Zinc finger protein 500 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] GPQLWPK 6.889999866 0.355772994 825.1924762 0 15.50632 12.55639 17.22554 13.5417 A0A8C0MR23 A0A8C0MR23_CANLF Zinc finger protein 556 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] metal ion binding [GO:0046872] DVMLETFR 2.190000057 0.210204851 1027.288735 13.42666 12.41088 0 0 11.65233 A0A8C0NYA2 A0A8C0NYA2_CANLF Zinc finger protein 630 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] metal ion binding [GO:0046872] ETSSMY 5.659999847 0.350471546 732.762381 15.10342 0 15.28616 16.50125 15.69358 A0A8C0SD93 A0A8C0SD93_CANLF Zinc finger protein 646 ZNF646 Canis lupus familiaris (Dog) (Canis familiaris) HGGSLVNHR 5.460000038 0.380287483 976.9724943 18.69035 16.32473 0 15.82598 15.03649 A0A8C0LTQ9 A0A8C0LTQ9_CANLF Zinc finger protein 671 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] DNA binding [GO:0003677]; metal ion binding [GO:0046872] GGEGRDSMK 9.930000305 0.243163267 934.0592208 17.62975 16.29847 15.84629 17.88368 15.84989 A0A8C0NSQ7 A0A8C0NSQ7_CANLF Zinc finger protein 789 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] metal ion binding [GO:0046872] KPTPKQK 15.89000034 0.220554714 826.2294986 15.43633 16.26489 17.20083 16.02507 15.2479 A0A8C0MRN0 A0A8C0MRN0_CANLF Zinc finger protein 827 ZNF827 Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338]; establishment of protein localization to telomere [GO:0070200]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of shelterin complex assembly [GO:1904791]; telomere maintenance [GO:0000723] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]" metal ion binding [GO:0046872]; NuRD complex binding [GO:0120325] HTGEDR 9.569999695 0.399359362 713.6766566 15.12584 16.6105 17.0205 15.68331 16.58879 A0A8C0P8K2 A0A8C0P8K2_CANLF Zinc finger protein SNAI2 (Protein snail homolog 2) SNAI2 Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to epidermal growth factor stimulus [GO:0071364]; desmosome disassembly [GO:0035921]; epithelial to mesenchymal transition [GO:0001837]; negative regulation of anoikis [GO:2000811]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of vitamin D biosynthetic process [GO:0010957]; negative regulation of vitamin D receptor signaling pathway [GO:0070563]; neural crest cell development [GO:0014032]; Notch signaling pathway [GO:0007219]; osteoblast differentiation [GO:0001649]; pigmentation [GO:0043473]; positive regulation of cell migration [GO:0030335]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of chemokine production [GO:0032642]; regulation of osteoblast differentiation [GO:0045667]; sensory perception of sound [GO:0007605]" chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]" KSFSCK 8.699999809 0.272317678 755.529505 15.73282 17.24243 15.3786 16.31406 0 A0A8C0MJD1 A0A8C0MJD1_CANLF [histone H3]-lysine(4) N-trimethyltransferase (EC 2.1.1.354) SMYD1 Canis lupus familiaris (Dog) (Canis familiaris) heart development [GO:0007507]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myotube differentiation [GO:0010831]; skeletal muscle cell differentiation [GO:0035914] cytoplasm [GO:0005737]; nucleus [GO:0005634] histone H3K4 methyltransferase activity [GO:0042800]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] SMFHTQMR 1.809999943 0.027891754 1054.263169 13.53903 13.39507 13.90326 11.95333 15.00556 A0A8I3NYP5 A0A8I3NYP5_CANLF [histone H3]-trimethyl-L-lysine(4) demethylase (EC 1.14.11.67) KDM5B Canis lupus familiaris (Dog) (Canis familiaris) branching involved in mammary gland duct morphogenesis [GO:0060444]; cellular response to leukemia inhibitory factor [GO:1990830]; mammary duct terminal end bud growth [GO:0060763]; positive regulation of gene expression [GO:0010628]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; post-embryonic development [GO:0009791]; regulation of estradiol secretion [GO:2000864]; single fertilization [GO:0007338]; uterus morphogenesis [GO:0061038] cytosol [GO:0005829]; nucleoplasm [GO:0005654] histone binding [GO:0042393]; histone H3K4me/H3K4me2/H3K4me3 demethylase activity [GO:0034647]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270] EPLPSGKK 19.01000023 0.415510297 854.1899968 16.10951 16.7788 16.43458 17.42954 15.89469 A0A8C0Q761 A0A8C0Q761_CANLF adenylate cyclase (EC 4.6.1.1) ADCY3 Canis lupus familiaris (Dog) (Canis familiaris) acrosome reaction [GO:0007340]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cAMP biosynthetic process [GO:0006171]; cellular response to forskolin [GO:1904322]; flagellated sperm motility [GO:0030317]; intracellular signal transduction [GO:0035556]; olfactory learning [GO:0008355]; sensory perception of smell [GO:0007608] ciliary membrane [GO:0060170]; cytoplasm [GO:0005737] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] GGVLAGVIGAR 6.389999866 0.338622882 970.1895767 13.24971 16.52754 15.35714 16.38738 15.49991 A0A8C0N4S7 A0A8C0N4S7_CANLF adenylate cyclase (EC 4.6.1.1) ADCY4 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cAMP biosynthetic process [GO:0006171]; intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737]; dendrite [GO:0030425]; plasma membrane [GO:0005886] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase C binding [GO:0005080] MESTGVLGK 5.429999828 0.337551797 936.5009906 14.66306 16.10617 15.70723 15.95616 15.61274 A0A8I3QAZ6 A0A8I3QAZ6_CANLF cholestenol Delta-isomerase (EC 5.3.3.5) (Cholestenol Delta-isomerase) (Delta(8)-Delta(7) sterol isomerase) EBP Canis lupus familiaris (Dog) (Canis familiaris) sterol biosynthetic process [GO:0016126] endoplasmic reticulum membrane [GO:0005789] cholestenol delta-isomerase activity [GO:0047750] ANDLSNSS 7.730000019 0.221772039 808.2432694 15.1802 16.34611 15.7036 14.47895 15.47024 A0A8I3NZN6 A0A8I3NZN6_CANLF coproporphyrinogen oxidase (EC 1.3.3.3) CPOX Canis lupus familiaris (Dog) (Canis familiaris) heme A biosynthetic process [GO:0006784]; heme B biosynthetic process [GO:0006785]; heme O biosynthetic process [GO:0048034]; protoporphyrinogen IX biosynthetic process [GO:0006782] cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial intermembrane space [GO:0005758] coproporphyrinogen oxidase activity [GO:0004109]; protein homodimerization activity [GO:0042803]; structural constituent of eye lens [GO:0005212] DLGTSVK 1.940000057 0.3337241 718.554209 14.90397 15.38801 18.19082 16.45507 16.26296 A0A8C0TPG6 A0A8C0TPG6_CANLF dolichyl-phosphate-mannose--protein mannosyltransferase (EC 2.4.1.109) TMTC4 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] AFRETGNK 6 0.359102733 922.7186369 14.41926 17.39856 15.32159 15.01926 16.41978 A0A8C0P0F0 A0A8C0P0F0_CANLF guanylate cyclase (EC 4.6.1.2) Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737] GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; heme binding [GO:0020037] MSGYDR 3.160000086 0.455596109 744.9759369 14.74758 15.29733 15.61358 16.41465 14.68196 A0A8C0MXK4 A0A8C0MXK4_CANLF heparosan-N-sulfate-glucuronate 5-epimerase (EC 5.1.3.17) Canis lupus familiaris (Dog) (Canis familiaris) heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparin biosynthetic process [GO:0030210] membrane [GO:0016020] heparosan-N-sulfate-glucuronate 5-epimerase activity [GO:0047464] YGLNMR 3.519999981 1.22E-13 768.7144879 11.60516 7.866532 10.66973 12.49997 12.46014 A0A8C0N393 A0A8C0N393_CANLF leucine--tRNA ligase (EC 6.1.1.4) Canis lupus familiaris (Dog) (Canis familiaris) leucyl-tRNA aminoacylation [GO:0006429] aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; leucine-tRNA ligase activity [GO:0004823] MLFSGK 3.789999962 0.36130574 682.8783817 15.56409 15.96769 15.0616 15.18638 14.48703 A0A8C0SHY1 A0A8C0SHY1_CANLF long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) ACSL4 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid metabolic process [GO:0006631] membrane [GO:0016020] nucleotide binding [GO:0000166] IVSMTK 7.170000076 0.419045271 692.9768577 16.04318 15.26471 17.12337 14.72053 15.76966 A0A8C0RUN3 A0A8C0RUN3_CANLF medium-chain acyl-CoA ligase (EC 6.2.1.2) LOC479822 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] acid-thiol ligase activity [GO:0016878]; CoA-ligase activity [GO:0016405]; nucleotide binding [GO:0000166] DGWLDFR 5.949999809 0.191378392 908.8643434 15.87981 11.21882 14.01865 15.5201 13.28353 A0A8C0SPK0 A0A8C0SPK0_CANLF methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) MTHFD2 Canis lupus familiaris (Dog) (Canis familiaris) one-carbon metabolic process [GO:0006730] methylenetetrahydrofolate dehydrogenase (NADP+) activity [GO:0004488] NEPTLAGAGR 2.170000076 0.391431559 985.090364 14.41501 13.98175 15.3212 15.65434 15.14351 A0A8C0MH91 A0A8C0MH91_CANLF methylated diphthine methylhydrolase (EC 3.1.1.97) Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787] EGGDGGSK 6.349999905 0.299619509 704.7375373 16.08013 16.07539 17.19742 14.76474 15.96872 A0A8C0PYS7 A0A8C0PYS7_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) MINK1 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; positive regulation of JNK cascade [GO:0046330]; regulation of cell migration [GO:0030334]; regulation of cell-cell adhesion [GO:0022407]; regulation of cell-matrix adhesion [GO:0001952] Golgi apparatus [GO:0005794] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] ALDDAPRPPK 5.25 0.236712418 1080.914987 12.27514 15.48289 15.86423 16.45397 14.16018 A0A8C0P5L2 A0A8C0P5L2_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) NEK1 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; phosphorylation [GO:0016310] centriolar satellite [GO:0034451]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; pericentriolar material [GO:0000242] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] SEISPEKEK 6.019999981 0.135052883 1045.857615 11.0254 14.17355 2.17274 13.65106 11.82152 A0A8C0Z461 A0A8C0Z461_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) NEK8 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672] SLVPGSTGSR 15.59000015 0 960.4346044 17.64516 15.57797 0 15.50533 0 A0A8C0PGD6 A0A8C0PGD6_CANLF peptide-methionine (S)-S-oxide reductase (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Protein-methionine-S-oxide reductase) MSRA Canis lupus familiaris (Dog) (Canis familiaris) peptide-methionine (S)-S-oxide reductase activity [GO:0008113] EPIPVAAK 11.27999973 0.051621327 823.4106225 15.67543 14.45718 13.35189 16.0383 15.62408 A0A8I3Q9F2 A0A8I3Q9F2_CANLF phosphoinositide 5-phosphatase (EC 3.1.3.36) INPP5B Canis lupus familiaris (Dog) (Canis familiaris) flagellated sperm motility [GO:0030317]; in utero embryonic development [GO:0001701]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of protein processing [GO:0070613]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283] cytosol [GO:0005829]; early endosome membrane [GO:0031901]; phagocytic vesicle membrane [GO:0030670] "inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]" SEITDMVR 4.960000038 0.329485129 966.1400873 15.9039 14.19229 17.82786 14.12699 13.36984 A0A8C0P883 A0A8C0P883_CANLF phosphopyruvate hydratase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) ENO2 Canis lupus familiaris (Dog) (Canis familiaris) glycolytic process [GO:0006096] phosphopyruvate hydratase complex [GO:0000015] magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634] FAGHNFR 7.630000114 0.053104756 849.4093051 16.04271 15.99898 14.44801 15.45775 0 A0A8C0NFP9 A0A8C0NFP9_CANLF phytanoyl-CoA dioxygenase (EC 1.14.11.18) (Phytanic acid oxidase) (Phytanoyl-CoA alpha-hydroxylase) Canis lupus familiaris (Dog) (Canis familiaris) fatty acid alpha-oxidation [GO:0001561] phytanoyl-CoA dioxygenase activity [GO:0048244] QMIIMR 7.690000057 0.23241667 808.0441145 19.73929 17.71155 18.69139 20.49846 19.8564 A0A8C0P0P5 A0A8C0P0P5_CANLF procollagen galactosyltransferase (EC 2.4.1.50) COLGALT1 Canis lupus familiaris (Dog) (Canis familiaris) transferase activity [GO:0016740] LLNLMR 31.62999916 0.266432594 776.4463001 18.82039 17.54567 21.15632 17.21699 17.30756 A0A8C0QJ32 A0A8C0QJ32_CANLF protein-serine/threonine phosphatase (EC 3.1.3.16) Canis lupus familiaris (Dog) (Canis familiaris) dephosphorylation [GO:0016311] nucleus [GO:0005634] MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017] TLGSGQRGR 3.589999914 0.131406078 931.6517826 15.6709 14.75731 16.98349 17.58043 16.19349 A0A8C0P3Z9 A0A8C0P3Z9_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) (Phosphatidylinositol-3-phosphate phosphatase) MTMR3 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] cytoplasm [GO:0005737]; membrane [GO:0016020] metal ion binding [GO:0046872]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphoprotein phosphatase activity [GO:0004721] IPAVVYR 3.640000105 0.46948398 818.9549779 14.00605 15.84841 15.08304 15.74405 15.4092 A0A8C0M9B7 A0A8C0M9B7_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) PTPN14 Canis lupus familiaris (Dog) (Canis familiaris) dephosphorylation [GO:0016311]; lymphangiogenesis [GO:0001946]; negative regulation of cell population proliferation [GO:0008285]; regulation of protein export from nucleus [GO:0046825] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleoplasm [GO:0005654] protein tyrosine phosphatase activity [GO:0004725]; receptor tyrosine kinase binding [GO:0030971]; transcription coregulator activity [GO:0003712] VEVPMMLR 3.869999886 0.349360501 990.066196 16.02973 13.93427 0 14.7017 14.13916 A0A8I3NTM6 A0A8I3NTM6_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) PTPRS Canis lupus familiaris (Dog) (Canis familiaris) cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; corpus callosum development [GO:0022038]; dephosphorylation [GO:0016311]; establishment of endothelial intestinal barrier [GO:0090557]; hippocampus development [GO:0021766]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of axon extension [GO:0030517]; negative regulation of axon regeneration [GO:0048681]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of dendritic spine development [GO:0061000]; negative regulation of interferon-alpha production [GO:0032687]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of toll-like receptor 9 signaling pathway [GO:0034164]; regulation of postsynaptic density assembly [GO:0099151]; spinal cord development [GO:0021510]; synaptic membrane adhesion [GO:0099560]; trans-synaptic signaling [GO:0099537] cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685] chondroitin sulfate binding [GO:0035374]; heparin binding [GO:0008201]; protein tyrosine phosphatase activity [GO:0004725] MVWEQR 12.22999954 0.251341761 848.7022659 15.48307 15.1102 0 15.89465 14.58823 A0A8C0PQ63 A0A8C0PQ63_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) Canis lupus familiaris (Dog) (Canis familiaris) dephosphorylation [GO:0016311] membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] AGLGSGSGGGTPCAGPR 5.369999886 0.339283654 1457.268053 0 15.52633 18.13853 0 15.53011 A0A8C0N0Q2 A0A8C0N0Q2_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) Canis lupus familiaris (Dog) (Canis familiaris) cellular component organization [GO:0016043]; dephosphorylation [GO:0016311] membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] HYGGFTNK 6.289999962 0.295627137 923.7506077 14.7483 14.8584 15.91999 12.96206 14.6024 A0A8C0LXE7 A0A8C0LXE7_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) Canis lupus familiaris (Dog) (Canis familiaris) dephosphorylation [GO:0016311] protein tyrosine phosphatase activity [GO:0004725] HVRLQER 3.849999905 0.408013883 937.7306327 15.27293 15.09382 16.4057 16.27965 15.3203 A0A8C0RZM6 A0A8C0RZM6_CANLF rRNA biogenesis protein RRP36 RRP36 KLHDC3 Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] nucleolus [GO:0005730]; ribonucleoprotein complex [GO:1990904] QVVPISK 5.829999924 0.233691122 771.5401991 17.50885 15.90882 14.93191 12.73911 15.11399 A0A8C0N3E9 A0A8C0N3E9_CANLF receptor protein-tyrosine kinase (EC 2.7.10.1) EPHA1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; ephrin receptor activity [GO:0005003] MDQNSGAGAPR 3.480000019 0.159650386 1120.199613 13.31018 15.93235 12.58213 15.92647 17.57373 A0A8C0RIZ6 A0A8C0RIZ6_CANLF receptor protein-tyrosine kinase (EC 2.7.10.1) MST1R Canis lupus familiaris (Dog) (Canis familiaris) phosphorylation [GO:0016310]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] membrane [GO:0016020] ATP binding [GO:0005524]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] EGLLMR 13.88000011 0.343560612 734.9703098 15.40559 15.88902 16.98992 15.95093 16.36661 A0A8C0QCP1 A0A8C0QCP1_CANLF receptor protein-tyrosine kinase (EC 2.7.10.1) Canis lupus familiaris (Dog) (Canis familiaris) ERBB signaling pathway [GO:0038127] plasma membrane region [GO:0098590] ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713] VPGTGR 1.809999943 0.323821084 585.072418 14.96774 15.7076 15.1631 16.62944 14.14855 A0A8I3MJP3 A0A8I3MJP3_CANLF ribonuclease III (EC 3.1.26.3) DROSHA Canis lupus familiaris (Dog) (Canis familiaris) pre-miRNA processing [GO:0031054]; rRNA processing [GO:0006364] ribonuclease III activity [GO:0004525]; RNA binding [GO:0003723] QGNTCHR 9.93999958 0.038835782 871.3694125 0 14.87295 15.70865 7.939499 15.76582 A0A8C0RT85 A0A8C0RT85_CANLF separase (EC 3.4.22.49) ESPL1 Canis lupus familiaris (Dog) (Canis familiaris) nuclear chromosome segregation [GO:0098813]; nuclear division [GO:0000280]; proteolysis [GO:0006508] nucleus [GO:0005634] cysteine-type endopeptidase activity [GO:0004197] SKPEVPKAPR 2.970000029 0.181951942 1107.149712 13.73017 13.59794 9.27206 16.45312 14.06389 A0A8C0NF07 A0A8C0NF07_CANLF sphingomyelin phosphodiesterase (EC 3.1.4.12) SMPD3 Canis lupus familiaris (Dog) (Canis familiaris) BMP signaling pathway [GO:0030509]; bone growth [GO:0098868]; bone mineralization [GO:0030282]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to magnesium ion [GO:0071286]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; cellular response to peptide [GO:1901653]; cellular response to redox state [GO:0071461]; cellular response to tumor necrosis factor [GO:0071356]; ceramide metabolic process [GO:0006672]; chondrocyte development involved in endochondral bone morphogenesis [GO:0003433]; collagen metabolic process [GO:0032963]; dentinogenesis [GO:0097187]; DNA biosynthetic process [GO:0071897]; endochondral ossification [GO:0001958]; extracellular matrix assembly [GO:0085029]; G1 to G0 transition [GO:0070314]; hematopoietic progenitor cell differentiation [GO:0002244]; lung alveolus development [GO:0048286]; mitotic nuclear division [GO:0140014]; multicellular organism growth [GO:0035264]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; peptide hormone secretion [GO:0030072]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; polysaccharide transport [GO:0015774]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of smooth muscle cell proliferation [GO:0048661]; regulation of cartilage development [GO:0061035]; regulation of leukocyte migration [GO:0002685]; regulation of protein phosphorylation [GO:0001932]; sphingolipid mediated signaling pathway [GO:0090520]; sphingomyelin catabolic process [GO:0006685] extracellular region [GO:0005576]; Golgi cis cisterna [GO:0000137]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; neutral sphingomyelin phosphodiesterase activity [GO:0061751]; phosphatidic acid binding [GO:0070300]; phosphatidylserine binding [GO:0001786] TASVEYKGDGGR 5.369999886 0.185147991 1240.268872 15.47212 9.865022 14.22924 15.50593 12.60934 A0A8C0NJH4 A0A8C0NJH4_CANLF t-SNARE coiled-coil homology domain-containing protein BET1 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794] SKVTAIK 9.090000153 0.165891124 745.2527504 16.44192 15.82184 13.06812 14.19951 16.61031 A0A8C0TFY8 A0A8C0TFY8_CANLF tRNA-splicing endonuclease subunit Sen2 (EC 4.6.1.16) TSEN2 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA processing [GO:0006397]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; tRNA-intron endonuclease complex [GO:0000214] lyase activity [GO:0016829]; nucleic acid binding [GO:0003676]; tRNA-intron endonuclease activity [GO:0000213] MEGTTDR 7.989999771 0.465343122 809.8959764 15.54149 17.61281 15.39019 15.66271 16.52929 A0A8I3P9L1 A0A8I3P9L1_CANLF tRNA-t(6)A37 methylthiotransferase (EC 2.8.4.5) CDKAL1 Canis lupus familiaris (Dog) (Canis familiaris) maintenance of translational fidelity [GO:1990145] endoplasmic reticulum membrane [GO:0005789]; rough endoplasmic reticulum [GO:0005791] "4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; N6-threonylcarbomyladenosine methylthiotransferase activity [GO:0035598]; tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase [GO:0061712]" RVVDFLK 11.25 0.157312768 877.5319636 15.33412 12.88764 17.0442 15.56325 14.70164 A0A8C0TD32 A0A8C0TD32_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) VCPIP1 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843] LLSPILAR 10.39000034 0.247608794 883.7077382 17.91259 16.47009 16.42108 16.75986 16.75365